US3464412A - Intermixing syringe - Google Patents

Intermixing syringe Download PDF

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US3464412A
US3464412A US645264A US3464412DA US3464412A US 3464412 A US3464412 A US 3464412A US 645264 A US645264 A US 645264A US 3464412D A US3464412D A US 3464412DA US 3464412 A US3464412 A US 3464412A
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housing
plunger
piston
fluid
syringe
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Boris Schwartz
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BORIS SCHWARTZ
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/15003Source of blood for venous or arterial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150053Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061Means for enhancing collection
    • A61B5/150099Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150221Valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150259Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/150007Details
    • A61B5/150351Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150389Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • AHUMAN NECESSITIES
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    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150503Single-ended needles
    • A61B5/150519Details of construction of hub, i.e. element used to attach the single-ended needle to a piercing device or sampling device
    • AHUMAN NECESSITIES
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    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150732Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube
    • AHUMAN NECESSITIES
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    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
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    • A61B5/150007Details
    • A61B5/150755Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • AHUMAN NECESSITIES
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    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/153Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154Devices using pre-evacuated means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150213Venting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150305Packages specially adapted for piercing devices or blood sampling devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3103Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104Caps for syringes without needle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3103Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3106Plugs for syringes without needle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed

Description

Sept. 2, 1969 B. SCHWARTZ INTERMIXING SYRINGE Filed June 12. 1967 2 Sheets-Sheet 1 INVENTOR.

501%" SCHWARTZ B Y 7 AGE/v77 Sept. 2, 1969 SCHWARTZ 3,464,412

INTERMIXING SYRINGE Filed June 12. 1967 2 Sheets-Sheet 2 80 r /O i mx I T L -Ull-'.!l.'..'.!.

INVENTOR. BORIS SCHWARTZ United States Patent 3,464,412 INTERMIXING SYRINGE Boris Schwartz, 400 Park Ave., Paterson, NJ. 07504 Filed June 12, 1967, Ser. No. 645,264 Int. Cl. A61m 5/00; A61j l/00; B67d 5/42 US. Cl. 128-218 9 Claims ABSTRACT OF THE DISCLOSURE A syringe combination having an outer housing and a hollow plunger providing a pair of chambers of determined size. The plunger is provided with a piston having a plurality of spaced, ring-like sealing surfaces and with a fluid passage-way from the interior of the plunger which is flow-connected to the outer piston surface and between ring-like sealing surfaces. The outer housing has one or more recesses of determined size formed in its inner surface with the recesses positioned near the open end of the housing and of a length so that the rearmost sealing surface of the plunger piston engages the housing between the recesses and the rear end of the housing when the flow-connection is brought into a fluid conducting position with the recess.

BACKGROUND OF THE INVENTION Field of the invention This invention relates to the general class of surgery and more particularly to the subclass of syringes.

Description of the prior art Syringes are well known in the general field of surgery and those for storing and intermixing various ingredients are represented in patents as to Pierick, U .8. Patent No. 3,279,654 of October 1966; to Brown, US. Patent No. 2,591,046 of April 1952, and to Camber, Great Britain No. 746,057 of January 1959. These and other patents use gravity to induce a flow from one chamber to another. This method of transfer is often uncertain and sometimes is incomplete or requires an exact manipulation by the user who may not have the required skill or training. The precise and exact mixing of the various components comprising some of the new medicants is an absolute necessity. Ease of mixing by any potential administrator of the medicant is necessary and desirable, and an easily manipulative device is an object of this invention.

The syringe of present invention provides a means for bringing the interior of the housing of the syringe into a condition of reduced pressure, whereupon as a flow-conducting portion of a piston of a hollow plunger is brought into a fluid passing or mixing position, the fluid which is preferably stored in the plunger is sucked from the plunger interior to flow to the housing chamber for a controlled mixing of the stored ingredients.

SUMMARY OF THE INVENTION This invention provides a syringe-type apparatus having an outer housing of generally tubular construction which is formed with an open end and a closed end. This closed end has an aperture or passageway for the passage of medicants and the like which is usually to and through a needle. The plunger is slidable in the bore of the housing and is formed with a hollow interior and has one end provided with a piston having a fluid-flow passageway extending from between a pair of ring-type sealing surfaces and to the interior of the plunger. The inner surface of the barrel portion of the outer housing has formed therein at least one recess of a determined length, width and depth and adapted to provide a fluid passageway from the interior of the plunger to and around one of the sealing rings and thence to the foreportion of the housing.

In one embodiment of this invention the syringe is arranged as an intermixing syringe in which one ingredient is stored in the foreportion of the housing and another and preferably fluid ingredient is stored in the hollow plunger portion. In a modification of the intermixing syringe, the outer plunger portion is provided with a resilient bulb end so that the after mixing of the ingredients the syringe may be used as a medicant dropper. In use, in either of the above embodiments, the foreportion of the housing is sealed so that as the plunger is moved outwardly the pressure in the housing foreportion is caused to be reduced.

The two ring-type sealing surfaces between which one end of the fluid-flow passageway is terminated are at the forward or inner end of the plunger. Extending rearwardly from the second ring surface is a piston portion preferably having at least one more ring or formed as a continuation of the second ring. This sealing surface rearwardly of the second ring is preferably of a length great enough so that as this sealing means is moved across the recess in the housing the fluid-flow portion of the piston is sealed from passing rearwardly of the sealing means and out of the housing. The arrangement of the sealing surfaces on the plunger piston is made of a length great enough so that when the innermost ring is brought into a fluid-flow condition with the recess in the housing the remaining sealing surfaces seal the housing bore so as to prevent flow of fluid or atmosphere to and from the open end of the housing to the plunger interior or to the foreportion of the housing.

In yet another embodiment of the invention the syringe is intended to be used as a vacuum container in which the hollow plunger portion is a test tube which may be furnished with small predetermined quantities of various blood treating fluids stored in the test tube. By manipulation, the test tube or plunger and the interior of the housing is caused to be brought into a condition of reduced pressure after which the plunger in the reduced pressure condition is moved to a storing position after which the interior of the housing is opened to the atmosphere to bring the interior of the housing to atmospheric pressure. At the time of use, the fore-end or closed end of the housing has a needle mounted on a hub portion.

The apparatus with the needle attached is used as a syringe to withdraw a blood sample from the patient and to secure and store a determined quantity of blood within the syringe. After the desired amount of blood is drawn into the housing, the syringe is manipulated to draw the blood into the test tube. When the transfer of the blood to the test tube is completed the needle is discarded and the test tube is moved fully into the housing for shipment to the laboratory. At the time the blood sample is to be tested, the housing and the piston are discarded and the test tube with the blood therein is tested or treated in the usual manner.

It is an object of this invention to provide an intermixing syringe assembly in which two or more medicants are isolated for storage and which at a determined time and by manipulative action are mixed immediately prior to the use thereof. The intermixing of the components is provided when the plunger is manipulated to move the plunger outwardly so that the housing is brought into a condition of reduced pressure after which the piston of the syringe is brought into a fluid-passing position so that the fluid stored in the plunger is caused to be sucked into the reduced pressure portion of the housing portion for agitated mixing.

It is a further object of this invention to provide an intermixing syringe wherein the medicants may be isolated for storage and which, at the time of mixing, the

ingredients may be brought into comingle relationship with each other and in which the exterior end portion of the plunger is provided with a resilient bulb member adapted to act with the syringe as a medicant dropper.

It is a further object of this invention to provide a syringe apparatus in which the plunger is a test tube having a piston portion on its open end and adapted to slide within a housing so that the test tube may be brought to a condition of reduced pressure. The closed end of the housing is adapted to mount a needle for the drawing of blood from a patient and after the drawing of a determined quantity of blood into the housing this blood is transferred by manipulation of the plunger into the test tube for storage and transport.

There has been outlined rather broadly the most important features of the various embodiments of the syringe apparatus of this invention in order that the present contribution to the art may be more fully appreciated. Those persons skilled in this art will appreciate that the concept on which the present disclosure is based may be utilized to provide the basis for other syringe devices similarly carrying out the purposes of this invention. The chosen embodiments of the apparatus are provided for the purposes of illustration and description of the principles of this invention and are shown in the accompanying drawings forming a part of the specification wherein:

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 represents a sectional view of an intermixing syringe in which the components to be mixed are shown as stored in two separated compartments or members of the syringe;

FIG. 2 represents the syringe of FIG. 1 with the components brought into mixing relationship within the housing member;

FIG. 3 represents the syringe of FIG. 1 and showing a needle attached to the housing and the syringe after the contents have been expelled therefrom;

FIG. 4 represents a sectional view taken on the line 44 of FIG. 1 and showing one embodiment of a fluid bypass recess as formed in the outer housing member;

FIG. 5 represents a sectional view through an alternate embodiment in which the hollow plunger is a test tube;

FIG. 6 represents a sectional view through yet another embodiment in which the plunger outer end is provided with a resilient bulb and the plunger and housing are adapted for mixing and for dispensing of a medicant in the manner of a dropper;

FIG. 7 represents a sectional view showing an end closure or cap for mounting on the discharge end of the housing of FIG. 6;

FIG. 8 represents a side view of an outer housing with a portion of the side wall broken away to show yet another form of a fluid bypass formed in the housing inner wall;

FIG. 9 shows a fragmentary and sectional side view of the fluid bypass of FIG. 8, the view taken on the line 9-9 of FIG. 10, and

FIG. 10 shows a sectional view of the housing as taken on the line 10-10 of FIG. 8.

DESCRIPTION OF THE PREFERRED EMBODIMENTS Referring now particularly to the drawings in which like numbers refer to like members throughout the various figures and in particular to the intermixing syringe shown in FIGS. 1 through 4, in which is shown an outer housing of conventional configuration and including a reduced front end 21 sized so as to retain a needle on its outer tapered end. This housing has an open rear end with an outer flange portion 22 providing a shoulder or stop for the users fingers. The interior diameter of this housing 20 is substantially round and constant with the exception of a portion near the rear in which is provided a fluid bypass in the form of outwardly extending scallops 24. These scallops are particularly seen in FIGS. 1 and 4 and, as reduced to practice, are in the form of arcuate cuts approximately one-quarter of an inch long and with a depth and width of one-sixteenth of an inch at their maximum. At the rear end of the housing 20 it is to be noted that a small internal lip 25 is formed in order to provide a limit means or stop for the outward movement of a plunger member 30.

Referring now to the movable plunger member generally identified as 30, it is to be noted that a generally tubular portion 31 has a reduced front end upon which is fitted a piston plunger preferably of rubber and identified as 32. This piston plunger, in the preferred instance, is formed with three outwardly extending like-sized resilient ring-like portions 33. Between the front first and second ring-like portions 33 there is formed a fluid passageway 34 extending from the inner portion of the plunger to and through the outer peripheral surface of the piston.

At the open or rearward end of the plunger 30 (as seen in FIG. 1) there is carried a movable piston 35 slidable within the interior diameter of the barrel 31. This piston is sized to provide a fluid tight slip fit and, in the present instance, is formed with two outwardly extending ring portions adapted to provide a fluid sealing means as well as sliding surfaces. At the rear end of the tubular portion 31, it is to be noted that there is a small internal shoulder or lip 36 provided to prevent or limit the unwanted outer movement of the piston 35.

It is also to be noted that the rear end of the plunger 30 is provided with a small grasping flange 38 for the easy gripping thereof by the fingers of the operator. Still referring to FIG. 1, it is to be noted that the reduced end of the outer housing 20 is provided with a vacuum or fluid seal in the form of a rubber or plastic plug 40 which is adapted to enter into a passageway 42 and seal this passageway both from the unwanted loss or entry of or plugging by powder and also to prevent the flow of air in and out of this passageway.

Referring next to FIG. 3, it is to be noted that a needle 44 is shown as mounted on the front end of the outer housing 20 after the plug 40 has been removed. This needle is of standard and conventional construction. After mounting on the syringe the insertion of this needle into the flesh or vein of the patient is in the manner of conventional practice.

OPERATION OF THE INTERMIX SYRINGE Within the interior 45 of the plunger 30, a determined amount of fluid 46 is stored in isolated condition and in that portion of the outer housing 20 which is forwardly of the piston 32, there is stored in isolated condition a powder portion 48. This powder is of a determined quantity and is stored without loss in isolation and is prevented from entering and packing in the fluid passageway 42 by means of the plug 40. In use, the interior forepart of the outer housing 20 identified as 49 is filled with the powder 48 of a determined quantity and consistency.

After the powder is placed in the housing, the plunger- 30 is then inserted a determined distance into the housing as in FIG. 1. The sealing ring portions 33 of the piston 32 after they are forwardly or inwardly of the fluid bypass 24 are sized to be in fluid tight relationship to the inner surface of the barrel 20 so that the fluid 46 which is then fed into the interior 45 of the plunger 30 for storage therein is sealed by means of the rings 33 and, as assembled in FIG. 1, is in condition for premix storage. This syringe with the isolated fluid and powder may be shipped and stored for such period of time as is necessary and so that those medicants having ingredients which are mixed just prior to use may be fully mixed at that time.

To mix the fluid and powder, the plunger 30 is slowly pulled towards the rear of the housing 20 so that the rearward first and second rings 33 of the piston 32 pass by the fluid bypass 24. It is to be noted that as they pass by this bypass portion that two of the three rings 33 are spaced so as to always be in a housing sealing position. As the plunger 30 is drawn backwardly, the interior volume of air in the housing is caused to expand, so that a reduced pressure is developed within the interior of the housing 20. As the midring 33 of the piston is brought behind the fluid bypass 24, the front ring 33 of the piston is spaced to engage or come in the way of the fluid bypass so that the interior passageway 34 of the piston is in flow communication with the housing interior. The reduced pressure in the housing causes the fluid to flow from the plunger passageway 34 and into the forward interior of the housing 20. This is done rapidly by means of the differential of pressure.

In order to provide means for the fluid to rapidly flow into the powder chamber without exposing the fluid in the plunger to atmospheric pressure or to possible contamination, the freely movable piston 35 is permitted to slide forward in the barrel of the plunger 30. This piston is drawn forwardly to replace the fluid as the fluid is drawn into the housing by the negative pressure induced within the outer housing.

The entire amount of fluid may be transferred rapidly in a very short time to instantly mix the powder and the fluid. Once the two components have been brought into a mingled relationship, the sealing plug 40 is withdrawn and the needle 44 is mounted upon the reduced front end 21 of the tapered shank portion of the outer housing. The syringe now becomes, in effect a conventional syringe with the mixed ingredients in the housing ready for injection in the customary manner. The plunger is manipulated in the conventional manner to expel any air residual in the barrel and to advance the fluid to the tip of the needle prior to the insertion of the needle into the patient after which the entire intermix contents may be injected into the patient.

When it is desired to cause the fluid to transfer from the plunger to the housing at a less than rapid rate, the plunger is manipulated so that a determined amount of recess is brought in the way of the front sealing ring. The more area of the recess exposed to the sealing surface of the front seal the more rapid is the rate of transfer. As reduced to practice, the rate of transfer of fluid has been a slow flow at the rate of a mist to a maximum flow of a jet stream.

DESCRIPTION OF OTHER EMBODIMENTS Referring now to FIG. 5 and a syringe in which the plunger is a test tube and in which an outer housing 60 is similar to the housing 20 above-described, this housing 60 is formed with a closed and reduced front end 62 sized to receive and retain a needle, not shown, but which may be the needle 44 (FIG. 3) above-described. Within the front end of this housing is shown a plug 40 as previously described which plug seals a passageway 64 within the housing 60. The rear end of the housing is open and has a small internally formed lip 77 providing a stop means in the manner of lip 25 above. The outer portion of the housing 60 is formed with ribs 66 and 67 which provide means for easy grasping and retaining of the housing in the hands of the user.

Within this housing there is a plunger member which, in this embodiment, includes a glass test tube 70 whose open end is closed by a rubber stopper and piston combination 72. The rear or left end portion of the stopperpiston is sized to close and seal the open end of the test tube 70 while the foreportion of the piston is formed with three fluid-sealing ring portions preferably substantially equally spaced. A fluid passageway 74 is provided between the first and second rings 75 reading from the right to the left as seen in the FIG. 5 and a third ring adjacent the test tube provides an extended sealing means. The fluid passageway extends from the interior of the test tube to the outer surface between the first and second sealing rings.

In use, the test tube 70 may have stored within it one or more fluids or other materials used for making blood determinations. Among such materials are potassium oxalate; sodium heparin; lithium oxalate; sodium oxalate; potassium oxalate and sodium fluoride; ammonium oxalate or mixtures of the above, and mineral oil may be used for other determinations. The quantities and selection of material that may be combined within the test tube 70 is merely a suggestion of the various anticoagulants or other materials used for determining blood tests. These materials are now customarily provided in measured quantities in test tubes so as to be combined with blood at the time of taking of the blood sample specimens. The test tube, of course, in many tests is sterilized in the customary manner and has nothing in it and may be used for other tests. The storing of anticoagulants, etc., in a test tube for use in certain test determinations is not to be implied as novel but is illustrative of one use for this embodiment.

OPERATION OF THE TEST TUBE SYRINGE It is contemplated that the syringe apparatus of FIG. 5 will be shipped assembled for use and with the stopperpiston portion 72 moved to the forward part of the outer housing 60 and with the plug 40 in an air sealing relationship with the passageway 64. Whether the test tube 70 also contains anticoagulants and the like or not is merely a matter of selection as determined by the intended use of the syringe. Prior to the use of this assembly as a syringe the test tube is grasped and moved leftwardly until piston 72 approaches the rear of the housing and the passageway 74 is brought in the way of a fluid bypass in the housing. As the piston moves leftwardly the air in the housing expands so that reduced pressure is developed in the forepart of the outer housing 60. As the front ring 75 of the piston comes in the way of the fluid bypass, the reduced pressure in the housing is allowed to communicate itself to the test tube 70 to provide a determined vacuum or reduced pressure in the test tube. The test tube is then pushed forward or rightwardly into the closed position, whence, as the front sealing ring is moved forwardly of the bypass, the vacuum within the test tube 70 is maintained. The test tube is advanced forwardly into the forward end of the housing after which the plug 40 is removed and a needle is mounted on the reduced front end 62.

The needle may then be inserted into a vein and, in the manner of a syringe and with the test tube acting as the plunger, it is pulled rearwardly so that the piston 72 acts in a usual manner to draw blood from the vein. After the desired amount of blood is drawn within the outer housing 60 the plunger is stopped and the needle is withdrawn from the vein. The plunger then may be moved to provide an exact determination of the amount of blood within the forward portion of the housing 60, as for example, by expelling a small amount of blood through the needle. After the quantity of blood is provided in the housing portion, the test tube is pulled rearwardly until the passageway 74 of the plunger is brought in the way of the fluid bypass, whereupon the reduced pressure in the test tube causes the blood to be drawn from the housing 60 and into the test tube 70.

After the transfer of blood from the housing to the test tube is completed, the piston portion and test tube is pushed forwardly within the container housing 60 and in this condition the test tube with the outer housing 60 acting as a shield may be transferred to the laboratory for the determination of the blood test. At the laboratory, with the housing passageway 64 open, the test tube is drawn to the back end of the housing 60. The piston is moved past a lip 77 of the rear of the housing and is removed therefrom with the housing 60 being discarded.

The stopper and piston portion 72 is drawn from the test tube opening and discarded after which the material in the test tube is tested in the usual manner. The test tube is preferably of conventional fire-resistant glass and after the test may be discarded.

It is to be noted in FIGS. 8, 9 and 10, that a preferred fluid bypass as formed in the outer housing is a triangular shape recess which is embossed in only one portion of the interior surface of the housing. The housing may be the housing 60 of FIG. with this embossure extending about one-quarter of an inch along the axis of the barrel and at its base at the rear of the housing being approximately one-quarter of an inch wide. The recess is preferably about ten or fifteen thousandths of an inch below the normal housing bore and generally throughout the triangular shape as shown. This fluid bypass provides the passage area generally necessary for the blood to be transferred from the housing to the interior of the test tube.

This triangular shape also provides a variable passageway whereby if the transfer to the test tube is to be very slow, the exposure of the forward ring to the triangular portion is made at the apex or forward end which is very small. When the piston is drawn further back its forward sealing ring portion is in the way of a larger portion of the bypass 80 and the blood or fluid will flow in a more rapid manner.

DESCRIPTION OF DROPPER-TYPE SYRINGE Referring finally to FIGS. 6 and 7, there is illustrated a modification of the syringe ofFIG. 1 wherein the forward portion of a housing 120 is provided with a male screw thread 121 instead of a needle receiving shank or taper. A screw cap 122 having a female thread portion is sized to engage and be advanced on the threaded end of the housing to seal the housing. In this arrangement the plug 40 is dispensed with or discarded, powder may be stored within the forepart 123 of the housing and fluid may be stored in a plunger portion 126 of the apparatus. It is to be noted that the rear of the plunger 126 is provided with a resilient bulb or diaphragm-type member 128 which is adapted to provide a means for pushing the fluid in drops from a discharge passageway 164 of the housing 120.

OPERATION OF THE DROPPER-TYPE SYRINGE In the manner as described in connection with the syringe of FIG. 1, the plunger 126 is pulled backwardly to allow the fluid within the plunger to be drawn forwardly through the bypass and into the reduced pressure portion of the fore-housing which contains the powder. After the mixing is accomplished, the mixed material is moved into the interior of the plunger portion. This is accomplished by causing a reduced pressure to be induced once again in the plunger by causing a piston 130 to be drawn back to bring the piston into a flow passing position with a recess and to permit the equalizing of pressure within the two members. After the piston is in the rearward position the screw cap is loosened to allow atmosphere to pass into the housing and, with the syringe pointed upward, the mixed material flows through the bypass into the plunger.

In certain applications it may be desirable to provide an additional bypass at the extreme forward portion of the housing so that the plunger, after being pushed all the way forward, will be in a flow communication with this additional forward bypass 180 to permit a fluid flow from the plunger. To discharge a drop of mixture the resilient diaphragm member 122 is pushed inwardly to cause a determined drop to flow through the passageway 132 of the piston 130 and into the bypass and then be discharged from the front passageway 164 in a manner of an eye dropper. With cap 122 in sealing engagement the mixed portion in the syringe may be carried around as a sealed eye dropper without the mixed material being accidentally expelled therefrom. When the screw cap is not in place, fluid flow sealing may be provided by pulling the plunger back sufliciently to bring all of the outwardly extending rings of the piston into sliding and sealing relationship with the outer barrel portion.

In the above-described embodiments, it is to be noted that the piston is formed with its sealing surfaces arranged so that as the piston is brought in the way of a bypass the fluid within the interior of the plunger is sealed from flowing out the rear or open end of the housing as the piston is moved over the bypass. Transfer of fluid from the hollow plunger to the foreportion of the housing occurs only when the fluid passageway adjacent the front sealing ring is brought into alignment with some portion of the bypass. The piston may be formed as a constant diameter portion for the extent which is shown as between the two rear sealing rings. This portion may also be a series of rings. This rear sealing portion provides means for preventing contamination and loss of fluid rearwardly from the housing and for this reason the rear sealing portion of the piston is formed of a length suflicient to cause sealing of the housing rearwardly when the piston fluid passageway is brought in the way of any of the bypass recesses.

It is also of note that the recess is preferably spaced in the housing so that as the rear of the piston engages the retaining lip of the housing, which lip provides an outward stop for the plunger, a maximum or near maximum fluid flow relationship is provided between the piston and bypass.

Terms such as left, right, in, out, fore, rear and the like are applicable to the embodiments as shown and described in conjunction with the drawings. These terms are merely for the purpose of description and do not necessarily apply to the various syringe embodiments shown and described and the manner in which they may be constructed or used.

The conception of the remote control signal system and its many applications is not limited to the specific embodiment shown but departures therefrom may be made within the scope of the accompanying claims and without sacrificing its chief advantages and protection is sought to the broadest extent the prior art allows.

What is claimed is:

1. An intermixing syringe for the isolated storage of at least two medicant portions and the like, the syringe in cluding an outer housing having an open rear end and a partially closed front end with a passageway therethrough, and a hollow plunger having a pisto portion slidable in the bore of the housing and in its hollow portion providing for the isolated storage of at least one of the portions, the syringe including means whereby at least one of the medicant portions may be selectively transferred from one of the storage positions to another storage position for the mixing of the portions, the syringe having means for bringing one of the storage portions into a condition of reduced pressure, the syringe comprising: (a) an outer housing of generally tubular configuration and having an inner bore of a generally constant cross-section and with at least one by-pass recess formed in the inner bore, the recess of a determined Width, length and depth and positioned at a determined distance from an open rear end of the housing, the housing having a front partially-closed other end and a passageway therethrough; (b) means for closing the passageway of the partially closed front end of the housing so as to prevent the passage of air, fluids and the like; (0) a plunger having a main portion of generally tubular configuration and sized to easily move axially in the bore of outer housing without the sealing of the bore of the housing; (d) means providing for the closing of the rear end of the plunger and the hollow portion thereof to the passage of air, fluid and the like wherein said means is a movable piston slideable within and throughout the interior bore of the plunger and providing therewith a fluid-tight sealing means, and (e) a resilient piston adapted for mounting in and closing the front end of the plunger, said piston formed with a plurality of ring-like sealing surfaces sized so as to be slidable in the bore of the housing while engaging said bore in a fluid-flow sealing manner, the piston having at least one flow passage way formed therein with one end of the passageway opening to the interior of the plunger and the other end terminating at the piston surface and between adjacent ringlike sealing surfaces, said sealing surfaces disposed and of an extent so that as the flow passageway terminating between the ring-like surfaces of the piston is brought in the way of the bypass recess so as to permit fluid flow from the plunger through the housing bypass said sealing surfaces of the piston that are beyond the flow passageway and adjacent the plunger main portion are disposed toward the housing open end to seal the housing and plunger from any unwanted flow of air, fluid and the like from the open end of the housing.

2. An intermixing syringe as in claim 1 in which the piston is made of a length so the axial extent of those rearwardly disposed sealing surfaces provided between the terminating flow passageway formed between ring-like sealing surfaces and the plunger main portion is at least slightly greater than the axial length of the bypass recess.

3. An intermixing syringe as in claim 2 in which the rearwardly disposed sealing surfaces include at least two outwardly extending ring-like sealing surfaces normally disposed to the axis of the piston.

4. An intermixing syringe as in claim 2 in which the adjacent ring-like sealing surfaces of the piston between which the flow passageway terminates are the forward pair of ring-like sealing surfaces of the piston.

5. An intermixing syringe as in claim 1 in which the means for closing the passageway in the housing front end is a resilient plug of plastic, rubber and the like, the plug having a shank portion sized for removable insertion into and closing of said passageway, and the front end of the housing formed with a hub portion adapted to receive and retain a needle.

6. An intermixing syringe as in claim 5 in which the housing bore at its open end is formed with a small internal lip providing a stop shoulder adapted to engage the rearward ring-like sealing surface of the piston to position the piston axially in the housing bore so as to bring the flow passageway of the piston into a flow conducting relationship with the bypass recess in the housing, and with a small internal lip formed in the plunger bore at its outer end providing a stop for limiting the outer movement of the movable piston in the plunger bore.

7. An intermixing syringe as in claim 3 in which the bypass recess is a plurality of arcuate cuts formed in the bore of the housing.

8. An intermixing syringe as in claim 3 in which the bypass recess is a triangular shaped recess formed in the housing bore and with the base of the triangular shape substantially parallel to the plane of the open rear end of housing.

9. An intermixing syringe as in claim 8 in which the housing bore at its open rear end is provided with a small internal lip providing a stop shoulder adapted to engage the rearward ring-like sealing surface of the piston to position the piston axially in the housing bore so as to bring the flow passageway of the piston into flow conducting relationship with the bypass recess in the housing.

References Cited UNITED STATES PATENTS 3,255,752 6/ 1966 Dick. 2,869,543 1/1959 Ratclilf et al. 3,279,654 10/1966 Pierick. 3,348,546 10/1967 Roberts et a1. l28272 RICHARD A. GAUDET, Primary Examiner M. F. MAJESTIC, Assistant Examiner US. Cl. X.R.

US645264A 1967-06-12 1967-06-12 Intermixing syringe Expired - Lifetime US3464412A (en)

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US64526467A true 1967-06-12 1967-06-12

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Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577850A (en) * 1968-09-26 1971-05-11 Precision Sampling Corp Method of forming seals
US3596652A (en) * 1968-10-14 1971-08-03 Bio Science Labor Fluid separatory device
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
US3706400A (en) * 1969-12-29 1972-12-19 Zyma Sa Distributor apparatus
US3739947A (en) * 1969-08-01 1973-06-19 E Baumann Storing and mixing receptacle
US3766917A (en) * 1968-01-26 1973-10-23 West Co Two compartment ampul syringe
US3889674A (en) * 1973-11-30 1975-06-17 Constabile A Cilento Mixing syringe
US3905521A (en) * 1974-05-21 1975-09-16 Thyroid Diagnostics Inc Reagent dispenser
US4185628A (en) * 1978-05-31 1980-01-29 Kopfer Rudolph J Compartmental syringe
US4340067A (en) * 1980-03-31 1982-07-20 Rattenborg Christen C Blood collection syringe
US4405249A (en) * 1980-03-28 1983-09-20 National Research Development Corporation Dispensing apparatus and method
EP0109970A1 (en) * 1982-11-29 1984-06-13 Frank W. Anastasio Blood sampling unit
US4469482A (en) * 1981-07-29 1984-09-04 Duphar International Research B.V. Disposable hypodermic syringe
US4472141A (en) * 1981-10-26 1984-09-18 Dragan William B All purpose dental syringe
US4516967A (en) * 1981-12-21 1985-05-14 Kopfer Rudolph J Wet-dry compartmental syringe
US4657028A (en) * 1983-02-21 1987-04-14 Radiometer A/S Blood sampling device
US4689042A (en) * 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
WO1988006568A1 (en) * 1987-03-04 1988-09-07 Package Research Corporation Toothpaste dispenser
US4809711A (en) * 1982-12-20 1989-03-07 Medicorp Holding S.A. Prefilled ampoule-syringe
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
US4921142A (en) * 1985-09-14 1990-05-01 Ing. Erich Pfeiffer Gmbh & Co. Kg Manually operable fluid dispenser
WO1994006365A1 (en) * 1992-09-23 1994-03-31 Habley Medical Technology Corporation Mixing container with combination stopper and pump
US5674195A (en) * 1995-02-06 1997-10-07 Truthan; Charles Edwin Syringe apparatus and method of mixing liquid medicants within a syringe
US5785683A (en) * 1995-07-17 1998-07-28 Szapiro; Jaime Luis Disposable syringe with two variable volume chambers
US6210359B1 (en) 2000-01-21 2001-04-03 Jet Medica, L.L.C. Needleless syringe
US6554792B2 (en) 1999-05-21 2003-04-29 Mallinckrodt Inc. Suspension device and method
EP1576933A1 (en) * 2004-03-11 2005-09-21 3M Espe Ag Capsule for storage, mixing and dispensing materials
US7007829B1 (en) * 2003-02-19 2006-03-07 Chief Packaging Company, Llc Hollow handle push-up piston for a food container
EP1759657A2 (en) * 2005-09-01 2007-03-07 3M Innovative Properties Company Capsule for storage, mixing and dispensing dental materials
US7503907B1 (en) 1999-10-22 2009-03-17 Antares Pharma, Inc. Medicament cartridge and injection device
US20090099510A1 (en) * 2006-01-31 2009-04-16 Novo Nordisk A/S Seal for a Prefilled Medical Jet Injection Device
CN101247842B (en) 2005-09-02 2010-12-29 莱博瑞特阿格坦特公司 Syringe designed to be pre-filled then sterilized by steam autoclaving
US20130048670A1 (en) * 2010-05-17 2013-02-28 Medmix Systems Ag Sealed glass container with a displaceable plunger
US20130098942A1 (en) * 2010-07-01 2013-04-25 Medmix Systems Ag Combined mixing and discharging device
US9850058B2 (en) 2015-09-11 2017-12-26 New Product Development Concepts Llc Telescoping syringe with one-way valve
US10391249B2 (en) * 2017-01-30 2019-08-27 Belal Hassanzadeh Dropper syringe apparatus

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2869543A (en) * 1957-08-23 1959-01-20 Iowa Cooperative Ass Injector
US3255752A (en) * 1965-01-28 1966-06-14 Dick Peter Hypodermic syringe
US3279654A (en) * 1965-02-08 1966-10-18 Richard L Pierick Syringe
US3348546A (en) * 1964-12-01 1967-10-24 Ralph R Roberts Intermixing syringe

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2869543A (en) * 1957-08-23 1959-01-20 Iowa Cooperative Ass Injector
US3348546A (en) * 1964-12-01 1967-10-24 Ralph R Roberts Intermixing syringe
US3255752A (en) * 1965-01-28 1966-06-14 Dick Peter Hypodermic syringe
US3279654A (en) * 1965-02-08 1966-10-18 Richard L Pierick Syringe

Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766917A (en) * 1968-01-26 1973-10-23 West Co Two compartment ampul syringe
US3577850A (en) * 1968-09-26 1971-05-11 Precision Sampling Corp Method of forming seals
US3596652A (en) * 1968-10-14 1971-08-03 Bio Science Labor Fluid separatory device
US3739947A (en) * 1969-08-01 1973-06-19 E Baumann Storing and mixing receptacle
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
US3706400A (en) * 1969-12-29 1972-12-19 Zyma Sa Distributor apparatus
US3889674A (en) * 1973-11-30 1975-06-17 Constabile A Cilento Mixing syringe
US3905521A (en) * 1974-05-21 1975-09-16 Thyroid Diagnostics Inc Reagent dispenser
US4185628A (en) * 1978-05-31 1980-01-29 Kopfer Rudolph J Compartmental syringe
US4405249A (en) * 1980-03-28 1983-09-20 National Research Development Corporation Dispensing apparatus and method
US4340067A (en) * 1980-03-31 1982-07-20 Rattenborg Christen C Blood collection syringe
US4469482A (en) * 1981-07-29 1984-09-04 Duphar International Research B.V. Disposable hypodermic syringe
US4472141A (en) * 1981-10-26 1984-09-18 Dragan William B All purpose dental syringe
US4516967A (en) * 1981-12-21 1985-05-14 Kopfer Rudolph J Wet-dry compartmental syringe
EP0109970A1 (en) * 1982-11-29 1984-06-13 Frank W. Anastasio Blood sampling unit
US4809711A (en) * 1982-12-20 1989-03-07 Medicorp Holding S.A. Prefilled ampoule-syringe
US4657028A (en) * 1983-02-21 1987-04-14 Radiometer A/S Blood sampling device
US4689042A (en) * 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4755169A (en) * 1985-05-20 1988-07-05 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4921142A (en) * 1985-09-14 1990-05-01 Ing. Erich Pfeiffer Gmbh & Co. Kg Manually operable fluid dispenser
WO1988006568A1 (en) * 1987-03-04 1988-09-07 Package Research Corporation Toothpaste dispenser
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
WO1994006365A1 (en) * 1992-09-23 1994-03-31 Habley Medical Technology Corporation Mixing container with combination stopper and pump
US5374249A (en) * 1992-09-23 1994-12-20 Habley Medical Technology Corporation Pharmaceutical mixing container with combination stopper and pump
US5674195A (en) * 1995-02-06 1997-10-07 Truthan; Charles Edwin Syringe apparatus and method of mixing liquid medicants within a syringe
US5785683A (en) * 1995-07-17 1998-07-28 Szapiro; Jaime Luis Disposable syringe with two variable volume chambers
US6554792B2 (en) 1999-05-21 2003-04-29 Mallinckrodt Inc. Suspension device and method
US20030105423A1 (en) * 1999-05-21 2003-06-05 Mallinckrodt Inc. Suspension device and method
US6871087B1 (en) 1999-05-21 2005-03-22 Mallinckrodt Inc. Suspension device and method
US7503907B1 (en) 1999-10-22 2009-03-17 Antares Pharma, Inc. Medicament cartridge and injection device
US6210359B1 (en) 2000-01-21 2001-04-03 Jet Medica, L.L.C. Needleless syringe
US7007829B1 (en) * 2003-02-19 2006-03-07 Chief Packaging Company, Llc Hollow handle push-up piston for a food container
EP1576933A1 (en) * 2004-03-11 2005-09-21 3M Espe Ag Capsule for storage, mixing and dispensing materials
WO2005094714A1 (en) * 2004-03-11 2005-10-13 3M Espe Ag Capsule for storage, mixing and dispensing materials
US9220578B2 (en) 2004-03-11 2015-12-29 3M Espe Ag Capsule for storage, mixing and dispensing materials
EP1759657A3 (en) * 2005-09-01 2009-04-29 3M Innovative Properties Company Capsule for storage, mixing and dispensing dental materials
EP1759657A2 (en) * 2005-09-01 2007-03-07 3M Innovative Properties Company Capsule for storage, mixing and dispensing dental materials
CN101247842B (en) 2005-09-02 2010-12-29 莱博瑞特阿格坦特公司 Syringe designed to be pre-filled then sterilized by steam autoclaving
JP2009525094A (en) * 2006-01-31 2009-07-09 ノボ・ノルデイスク・エー/エス Seal of the pre-filled medical jet injection device
US20090099510A1 (en) * 2006-01-31 2009-04-16 Novo Nordisk A/S Seal for a Prefilled Medical Jet Injection Device
US8920365B2 (en) * 2006-01-31 2014-12-30 Novo Nordisk A/S Seal for a prefilled medical jet injection device
US20130048670A1 (en) * 2010-05-17 2013-02-28 Medmix Systems Ag Sealed glass container with a displaceable plunger
US20130098942A1 (en) * 2010-07-01 2013-04-25 Medmix Systems Ag Combined mixing and discharging device
US9180417B2 (en) * 2010-07-01 2015-11-10 Medmix Systems Ag Combined mixing and discharging device
US9850058B2 (en) 2015-09-11 2017-12-26 New Product Development Concepts Llc Telescoping syringe with one-way valve
US10391249B2 (en) * 2017-01-30 2019-08-27 Belal Hassanzadeh Dropper syringe apparatus

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