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US3324847A - Radioactive catheter - Google Patents

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Publication number
US3324847A
US3324847A US40438664A US3324847A US 3324847 A US3324847 A US 3324847A US 40438664 A US40438664 A US 40438664A US 3324847 A US3324847 A US 3324847A
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Prior art keywords
body
member
radioactive
membrane
electrodes
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Expired - Lifetime
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Elias G Zoumboulis
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Elias G Zoumboulis
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1014Intracavitary radiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M25/0108Steering means as part of the catheter or advancing means; Markers for positioning using radio-opaque or ultrasound markers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • A61N1/306Arrangements where at least part of the apparatus is introduced into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019Sources therefor
    • A61N2005/1021Radioactive fluid

Description

June 13, 1967 E. G. ZQUMBOULIS RADIOACTIVE CATHETER Filed Oct. 16, 1964 I N VE N TOR. Z244 G. Zowvaouus United States Patent.

2 Claims. c1. 12s-1.2

This invention relates to a therapeutic device and was evolved with the general object of providing a catheter suitable for treatment of internal tissues by iontophoresis.

Balloon catheters are known wherein a flexible membrane is sealingly secured on an elongated member having a central passage for flow of fluids between the interior and exterior of a body, with means for introducing fluid into the flexible membrane to inflate it into a balloon disposed within the body in a manner to prevent removal of the catheter.

According to an important feature of this invention, a fluid containing radioactive material is introduced into the membrane of a balloon catheter for irradiation of the tissues within the body. Thus the catheter can perform the dual function of providing a passage for flow of fluid between the interior and exterior of the body, and providing treatment of the tissues Within the body. This dual function is highly advantageous in many applications, but in some applications it may not be required that a fluid flow path be provided, and hence the invention is not necessarily limited to a catheter type of therapeutic device.

Another important feature of the invention is in the provision of a pair of electrodes extending into a chamber on a member adapted to be inserted into a body orifice, such as the chamber defined by the membrane of a balloon catheter, the chamber being filled with an ionizable solution and the electrodes being arranged for connection to a source of current for migration of ions to one of the electrodes. Preferably, and in accordance with the first feature described above, the solution is in the form of a radioactive isotope. Radioactive iodine, for example, may be used.

The use of such electrodes in combination with a solution containing a radioactive isotope is particularly advantageous in that ions are formed in the solution and migrate to one of the electrodes in accordance with the laws of iontophoresis, to accumulate and form a solid radioactive source.

This invention contemplates other and more specific objects, features and advantages which will become more fully apparent from the following detailed description taken in conjunction with the accompanying drawings which illustrate a preferred embodiment and in which:

FIG. 1 is a longitudinal sectional view through a therapeutic device in .the form of a catheter constructed according to the principles of this invention; and

FIGURE 2 is a sectional view taken substantially along line IIII of FIGURE 1.

Reference numeral generally designates a therapeutic device in the form of a balloon or Foley type catheter, constructed in accordance with the principles of this invention. The device 10 comprises an elongated member 11 having a rounded end 12 for permitting easy insertion into a body cavity. For flow of fluids between the outside and inside of the body, the member 11 is in the form of a hollow tube having a central passage 13 with a hole 14 in the wall of the member adjacent the rounded end 12. The member 12 is preferably of rubber or a similar resilient material.

To prevent removal of the catheter, a flexible membrane 15 is sealingly secured about longitudinally spaced Patented June 13, 1967 outer wall portions of the member 11, to define an annular chamber 16, and a passage 17 is provided in the wall of the member 11, communicating at one end with the chamber 17 and at its opposite end with an inlet opening 18. By supplying fluid into the opening 18, the membrane 15 is expanded to form a balloon which may be spherical as illustrated, or of any desired configuration depending upon the application. Before such expansion, the membrane 15 is preferably pulled by its inherent resiliency closely against the outer surface of the member 11, to permit ready insertion of the device into a body cavity.

According to this invention, the chamber 16 is filled with a solution 20 of radioactive material, preferably radioactive iodine, for treatment of internal body tissues.

An important feature of the invention is in the provision of a pair of electrodes 21 and 22 within the chamber 16 integrally connected to the inner ends of wires 23 and 24 which extend through the wall of the member 11 to the outer end thereof. As diagrammatically illustrated, a battery 25, or other source of current, may be connected through a switch 26 to the ends of the wires 23 and 24. With an ionizable solution 20 in the chamber 16, ions will be formed in the solution and will migrate to one or the other of the electrodes 21 or 22, depending upon the polarity, in accordance with the laws of iontophoresis. With a radioactive isotope in the solution, a solid radioactive source can be readily formed on one or the other of the electrodes 21 or 22.

As illustrated, the electrode 21 is in the form of a ring engaged with the outer surface of the port-ion of the tubular member 11 within the membrane 15, while the electrode 22 is in the form of a wire, which preferably is positioned as shown in its unstressed condition with the chamber 20 filled with a solution, away from the electrode 21, but preferably has a resiliency such that in the initial condition of the device before inflation of the membrane 15, the electrode 22 may lie closely along the outer surface of the potrion of the member 11 within the membrane 15, so as to permit ready insertion of the device into a body orifice.

It may be noted that with the device of this invention, the solution in the chamber 20 can be withdrawn and replaced by a fresh solution, as required.

It is again noted that although the provision of the passage 13 for flow of fluid between the outside and the inside of the body is highly advantages in many applications, it is not always necessary. It is also noted that the membrane 15 need not be necessarily inflated to a spherical shape, but may take other shapes, depending upon the application, and other electrode arrangements may also be used.

It will be understood that other modifications and variations may be eflected without departing from the spirit and scope of the novel concepts of this invention.

I claim as my invention:

1. In a therapeutic device, an elongated member adapted to be inserted into a body orifice, means on said member defining a chamber containing an ionizable solution of a radioactive isotope, and a pair of electrodes extending into said chamber and arranged for connection to a source of electric current for migration of ions to one of said electrodes to form an accumulation of solid radioactive material on said one of said electrodes.

2. In a catheter, an elongated tubular member adapted to be inserted into a body orifice and having a central passage therethrough for flow of fluids between regions on the inside and outside of the body orifice, a flexible membrane sealingly secured on said elongated member, and means for introducing fluid into said membrane to expand said membrane into a balloon within the body,

said fluid containing radioactive material for irradiation of the interior of the body.

FOREIGN PATENTS 297,350 4/1917 Germany.

References Cited OTHER REFERENCES UNITED STATES PATENTS 5 Principles of Ray Irradiation by Kuenkel, pages 370- 1/1918 Galligan 128408 X 372 of Gynecology for April 1953.

6/1956 S33 128 1.2 X RICHARD A. GAUDET, Primary Examiner. 7/1963 Mann et a1 128-4 SIMON BRODER, Examiner.

Claims (1)

1. IN A THERAPEUTIC DEVICE, AN ELONGATED MEMBER ADAPTED TO BE INSERTED INTO A BODY ORIFICE, MEANS ON SAID MEMBER DEFINING A CHAMBER CONTAINING AN IONIZABLE SOLUTION OF A RADIOACTIVE ISOTOPE, AND A PAIR OF ELECTRODES EXTENDING INTO SAID CHAMBER AND ARRANGED FOR CONNECTION TO A SOURCE OF ELECTRIC CURRENT FOR MIGRATION OF IONS TO ONE OF SAID ELECTRODES TO FORM AN ACCUMULATION OF SOLID RADIOACTIVE MATERIAL ON SAID ONE OF SAID ELECTRODES.
US3324847A 1964-06-01 1964-10-16 Radioactive catheter Expired - Lifetime US3324847A (en)

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Cited By (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3872856A (en) * 1971-06-09 1975-03-25 Ralph S Clayton Apparatus for treating the walls and floor of the pelvic cavity with radiation
US4384584A (en) * 1981-10-28 1983-05-24 Chen Allen S Method and means for esophageal feeding
EP0205851A1 (en) * 1985-05-10 1986-12-30 Max Dr. Hubmann Catheter
US4758221A (en) * 1986-02-18 1988-07-19 St. Louis University Catheter with a tip manipulation feature
EP0438078A2 (en) * 1990-01-15 1991-07-24 Cino Rossi Iontophoresis device
US5059166A (en) * 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
DE9102312U1 (en) * 1991-02-27 1992-06-25 Weikl, Andreas, Dr.Med.
WO1992022350A1 (en) * 1991-06-14 1992-12-23 Williams Jeffery A Tumor treatment
US5199939A (en) * 1990-02-23 1993-04-06 Dake Michael D Radioactive catheter
US5277201A (en) * 1992-05-01 1994-01-11 Vesta Medical, Inc. Endometrial ablation apparatus and method
US5302168A (en) * 1991-09-05 1994-04-12 Hess Robert L Method and apparatus for restenosis treatment
US5443470A (en) * 1992-05-01 1995-08-22 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US5503613A (en) * 1994-01-21 1996-04-02 The Trustees Of Columbia University In The City Of New York Apparatus and method to reduce restenosis after arterial intervention
WO1996017654A1 (en) * 1994-12-08 1996-06-13 Omnitron International, Inc. Intravascular radiotherapy employing a liquid-suspended source
US5562720A (en) * 1992-05-01 1996-10-08 Vesta Medical, Inc. Bipolar/monopolar endometrial ablation device and method
WO1997037715A1 (en) 1994-10-27 1997-10-16 Novoste Corporation Radiation treatment of the vascular system
US5683345A (en) * 1994-10-27 1997-11-04 Novoste Corporation Method and apparatus for treating a desired area in the vascular system of a patient
US5707332A (en) * 1994-01-21 1998-01-13 The Trustees Of Columbia University In The City Of New York Apparatus and method to reduce restenosis after arterial intervention
US5728042A (en) * 1995-06-22 1998-03-17 Schneider (Europe) A.G. Medical appliance for ionizing radiation treatment having radiopaque markers
US5782742A (en) * 1997-01-31 1998-07-21 Cardiovascular Dynamics, Inc. Radiation delivery balloon
US5840008A (en) * 1995-11-13 1998-11-24 Localmed, Inc. Radiation emitting sleeve catheter and methods
US5882290A (en) * 1996-02-29 1999-03-16 Scimed Life Systems, Inc. Intravascular radiation delivery system
US5913813A (en) * 1997-07-24 1999-06-22 Proxima Therapeutics, Inc. Double-wall balloon catheter for treatment of proliferative tissue
US5931774A (en) * 1991-06-14 1999-08-03 Proxima Therapeutics, Inc. Inflatable devices for tumor treatment
US5938582A (en) * 1997-09-26 1999-08-17 Medtronic, Inc. Radiation delivery centering catheter
US6019718A (en) * 1997-05-30 2000-02-01 Scimed Life Systems, Inc. Apparatus for intravascular radioactive treatment
US6045495A (en) * 1994-01-21 2000-04-04 The Trustees Fo Columbia University In The City Of New York Apparatus and method to treat a disease process in a luminal structure
US6048299A (en) * 1997-11-07 2000-04-11 Radiance Medical Systems, Inc. Radiation delivery catheter
US6059812A (en) * 1997-03-21 2000-05-09 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
US6059713A (en) * 1997-03-06 2000-05-09 Scimed Life Systems, Inc. Catheter system having tubular radiation source with movable guide wire
US6071227A (en) * 1993-07-01 2000-06-06 Schneider (Europe) A.G. Medical appliances for the treatment of blood vessels by means of ionizing radiation
US6093142A (en) * 1998-04-30 2000-07-25 Medtronic Inc. Device for in vivo radiation delivery and method for delivery
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US6099454A (en) * 1996-02-29 2000-08-08 Scimed Life Systems, Inc. Perfusion balloon and radioactive wire delivery system
US6110097A (en) * 1997-03-06 2000-08-29 Scimed Life Systems, Inc. Perfusion balloon catheter with radioactive source
US6146322A (en) * 1995-12-05 2000-11-14 Schneider (Europe) Ag Irradiating filament and method of making same
US6149574A (en) * 1997-12-19 2000-11-21 Radiance Medical Systems, Inc. Dual catheter radiation delivery system
US6162165A (en) * 1997-12-05 2000-12-19 Cook Incorporated Medical radiation treatment device
US6196963B1 (en) 1999-03-02 2001-03-06 Medtronic Ave, Inc. Brachytherapy device assembly and method of use
US6203485B1 (en) 1999-10-07 2001-03-20 Scimed Life Systems, Inc. Low attenuation guide wire for intravascular radiation delivery
US6217503B1 (en) 1994-01-21 2001-04-17 The Trustees Of Columbia University In The City Of New York Apparatus and method to treat a disease process in a luminal structure
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Cited By (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3872856A (en) * 1971-06-09 1975-03-25 Ralph S Clayton Apparatus for treating the walls and floor of the pelvic cavity with radiation
US4384584A (en) * 1981-10-28 1983-05-24 Chen Allen S Method and means for esophageal feeding
EP0205851A1 (en) * 1985-05-10 1986-12-30 Max Dr. Hubmann Catheter
US4758221A (en) * 1986-02-18 1988-07-19 St. Louis University Catheter with a tip manipulation feature
US5059166A (en) * 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
EP0438078A3 (en) * 1990-01-15 1992-01-08 Cino Rossi Iontophoresis device
EP0438078A2 (en) * 1990-01-15 1991-07-24 Cino Rossi Iontophoresis device
US5199939A (en) * 1990-02-23 1993-04-06 Dake Michael D Radioactive catheter
DE9102312U1 (en) * 1991-02-27 1992-06-25 Weikl, Andreas, Dr.Med.
US6022308A (en) * 1991-06-14 2000-02-08 Proxima Therapeutics, Inc. Tumor treatment
US5931774A (en) * 1991-06-14 1999-08-03 Proxima Therapeutics, Inc. Inflatable devices for tumor treatment
US6083148A (en) * 1991-06-14 2000-07-04 Proxima Therapeutics, Inc. Tumor treatment
WO1992022350A1 (en) * 1991-06-14 1992-12-23 Williams Jeffery A Tumor treatment
US5429582A (en) * 1991-06-14 1995-07-04 Williams; Jeffery A. Tumor treatment
US5611767A (en) * 1991-06-14 1997-03-18 Oncocath, Inc. Radiation treatment of tumors using inflatable devices
USRE39157E1 (en) * 1991-09-05 2006-07-04 Calmedica, Llc Apparatus for restenosis treatment
US5302168A (en) * 1991-09-05 1994-04-12 Hess Robert L Method and apparatus for restenosis treatment
US5411466A (en) * 1991-09-05 1995-05-02 Robert L. Hess Apparatus for restenosis treatment
US5277201A (en) * 1992-05-01 1994-01-11 Vesta Medical, Inc. Endometrial ablation apparatus and method
US5443470A (en) * 1992-05-01 1995-08-22 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US5562720A (en) * 1992-05-01 1996-10-08 Vesta Medical, Inc. Bipolar/monopolar endometrial ablation device and method
US5713942A (en) * 1992-05-01 1998-02-03 Vesta Medical, Inc. Body cavity ablation apparatus and model
US6041260A (en) * 1992-05-01 2000-03-21 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US6506145B1 (en) 1993-05-04 2003-01-14 Advanced Cardiovascular Systems, Inc. Radioactive source wire, apparatus and treatment methods
US20020065448A1 (en) * 1993-05-04 2002-05-30 Bradshaw Anthony J. Method of treating a body vessel or duct with radiation from within the lumen
US6074338A (en) * 1993-07-01 2000-06-13 Schneider (Europe) A.G. Medical appliances for the treatment of blood vessels by means of ionizing radiation
US6514191B1 (en) 1993-07-01 2003-02-04 Schneider (Europe) A.G. Medical appliances for the treatment of blood vessels by means of ionizing radiation
US6071227A (en) * 1993-07-01 2000-06-06 Schneider (Europe) A.G. Medical appliances for the treatment of blood vessels by means of ionizing radiation
US5503613A (en) * 1994-01-21 1996-04-02 The Trustees Of Columbia University In The City Of New York Apparatus and method to reduce restenosis after arterial intervention
US6652441B2 (en) 1994-01-21 2003-11-25 The Trustees Of Columbia University In The City Of New York Apparatus and method to treat a disease process in a luminal structure
US6217503B1 (en) 1994-01-21 2001-04-17 The Trustees Of Columbia University In The City Of New York Apparatus and method to treat a disease process in a luminal structure
US5707332A (en) * 1994-01-21 1998-01-13 The Trustees Of Columbia University In The City Of New York Apparatus and method to reduce restenosis after arterial intervention
US6045495A (en) * 1994-01-21 2000-04-04 The Trustees Fo Columbia University In The City Of New York Apparatus and method to treat a disease process in a luminal structure
US6582352B2 (en) 1994-06-10 2003-06-24 Schneider (Europe) A.G. Medical appliance for treatment by ionizing radiation
US6231494B1 (en) 1994-06-10 2001-05-15 Schneider (Europe) A.G. Medical device with radiation source
US6616629B1 (en) 1994-06-24 2003-09-09 Schneider (Europe) A.G. Medical appliance with centering balloon
US5683345A (en) * 1994-10-27 1997-11-04 Novoste Corporation Method and apparatus for treating a desired area in the vascular system of a patient
US5899882A (en) * 1994-10-27 1999-05-04 Novoste Corporation Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
US7160238B1 (en) 1994-10-27 2007-01-09 Best Vascular, Inc. Method and apparatus for treating a desired area in the vascular system of a patient
US6306074B1 (en) 1994-10-27 2001-10-23 Novoste Corporation Method and apparatus for radiation treatment of a desired area in the vascular system of a patient
WO1997037715A1 (en) 1994-10-27 1997-10-16 Novoste Corporation Radiation treatment of the vascular system
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