US3308818A - Injection cartridge - Google Patents

Injection cartridge Download PDF

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US3308818A
US3308818A US385092A US38509264A US3308818A US 3308818 A US3308818 A US 3308818A US 385092 A US385092 A US 385092A US 38509264 A US38509264 A US 38509264A US 3308818 A US3308818 A US 3308818A
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container
inner container
outer container
propellant
deform
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US385092A
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Eugene V Rutkowski
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F42—AMMUNITION; BLASTING
    • F42B—EXPLOSIVE CHARGES, e.g. FOR BLASTING, FIREWORKS, AMMUNITION
    • F42B12/00—Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material
    • F42B12/02—Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material characterised by the warhead or the intended effect
    • F42B12/36—Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material characterised by the warhead or the intended effect for dispensing materials; for producing chemical or physical reaction; for signalling ; for transmitting information
    • F42B12/46—Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material characterised by the warhead or the intended effect for dispensing materials; for producing chemical or physical reaction; for signalling ; for transmitting information for dispensing gases, vapours, powders or chemically-reactive substances
    • F42B12/54—Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material characterised by the warhead or the intended effect for dispensing materials; for producing chemical or physical reaction; for signalling ; for transmitting information for dispensing gases, vapours, powders or chemically-reactive substances by implantation, e.g. hypodermic projectiles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2425—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst

Definitions

  • FIG. 1 A first figure.
  • FIG. 1 A first figure.
  • This invention relates to improvements in apparatus for effecting subcutaneous and intramuscular injections of medicaments and the like into human beings and animals, and more particularly to improvements for injection without the use of 'a hypodermic needle.
  • A. recent technique has evolved for subcutaneous injections without the use of a hypodermic needle in which a metered quantity of injectant is projected against the skin at such high pressure and velocity that it penetrates the skin.
  • Such technique is exemplified by the multi-dose injector, manufactured by the R. P. Sherer Company of Detroit, Mich.
  • Such device is quite complicated and expensive and requires an electric motor source for developing the requisite pressure for the injectant gun. In remote regions, where a source of electric power is not available, it therefore becomes unusable. Also, because of its considerable bulk and weight it presents transportation difficulties into such regions.
  • One of the objects of this invention is to provide a needleless injection device which contains a potential source of gas pressure which may be activated, when desired, and without any specialized power operated apparatus.
  • Another object is to provide a disposable device of such type for injecting a single metered dose.
  • a further object is to provide a disposable device of such type which may be constructed so economically that it can be made available to a greater number of users in need of the same.
  • FIG. 1 is an enlarged central section through one form of the invention
  • FIGS. 1A and 1B are like sections illustrating various stages of operation
  • FIG. 2 is a like section through another form of the invention.
  • FIG. 2A is a like section of FIG. 2 illustrating the final stage of operation
  • FIG. 3 illustrates a modified type of igniter
  • FIG. 4 illustrates a gun which may be optionally employed with any of the various forms of the invention.
  • the subject of the invention in one of its forms, comprises a cylindrical capsule or tube closed at one end by a closure 12 and in which is housed a spherical container 14 which is filled with the desired injectant fluid 16.
  • a head or cap member 18 sealingly closes the opposite end of the capsule to prevent leakage of high pressure gas.
  • the cap may thre-adedly engage the tube, as shown, or otherwise be sealingly secured to it such as by deforming the upper edge of the tube, as by rolling, over the upper edge of the cap.
  • cements, solders and the like may be employed to sealingly bond the cap to the tube.
  • a predetermined quantity of propellant powder 20 is disposed within the cylindrical capsule or tube 10, which 3,308,818 Patented Mar. 14, 1967 upon igniting, will produce a predetermined gas pressure within the capsule. Ignition of the propellant may be efiected by a conventional squib 22 containing a bridge wire (not shown) which is energized by electric current from a small portable battery, such as a flash light battery, through a suitable electric lead 24.
  • a small portable battery such as a flash light battery
  • the head or cap member is provided with an aperture 25 which leaves a small area of the spherical container wall unsupported and into which the wall may rupture when the injectant container is pressurized.
  • This aperture communicates with a small discharge orifice 26 through which the injectant is expelled at extremely high velocity, sufiicient to effect subcutaneous or intra-muscular penetration of the injectant.
  • FIG. 1A illustrates the deformation of the injectant container shortly after ignition of the squib at which time the wall has ruptured into aperture 25 and the fluid is being expelled through orifice 26 at high velocity.
  • FIG. 18 illustrates complete deformation or retroversion of the container in which the lower half of the spherical wall has engaged the upper half and the volume of the container has been reduced to its minimum.
  • the injectant container may be constructed of any material, such as metal or plastic, which is sufliciently ductile to deform, as illustrated, yet not rupture to permit entry of the high pressure gas into the container. In some instances it may be desirable to dispose a ductile heat shield at least adjacent the lower portion of the container to prevent excessive heat transmission to the container wall which might cause rupture by melting or other high temperature failure.
  • FIG. 2 illustrates a modified form of injectant container 14A which is dome-shaped at one end,-as in the previous embodiment, but is otherwise cylindrical in shape.
  • FIG. 2A illustrates the complete deformation of this container after being pressurized.
  • FIG. 3 illustrates another form of igriiter in the form of a percussion cap 22A which may be initiated by impact of a firing pin 30.
  • FIG. 4 is exemplary of a gun" 32 containing an injectant cartridge.
  • Any suitable movable closure 34 may be employed to permit insertion of the cartridge into the gun after which it may be initiated by a trigger 36 which may operate a hammer for the percussion type or operate a switch for the electric squib type.
  • the battery may cOnveniently be housed within the handle of the gun.
  • Apparatus for subcutaneous injections of liquid medicaments and the like comprising;
  • said inner container having a first portion of its wall supported by said outer container and a second portion adapted to deform into a retroversion contact with the first portion, without rupturing, to thereby reduce its volume to zero
  • Apparatus in accordance with claim 1 wherein the means for initiating combustion of said propellant comprises an electrically initiated squib.
  • Apparatus in accordance with claim 1 wherein the means for initiating combustion of said propellant comprises a percussion cap.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Combustion & Propulsion (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Description

March 1967 E. v. RUTKOWSKI INJECTION CARTRIDGE Filed July 24, 1964 A W R 2 0m E KE LO V L 6 N U l R] A F M V O 2 E N as E G W G C2 w m F x W FIG.
FIG.
FIG.
United States Patent 3,308,818 INJECTION CARTRIDGE Eugene V. Rutkowski, 1010 Esplanade, Apt. 17, Redondo Beach, Calif., 90277 Filed July 24, 1964, Ser. No. 385,092 Claims. (Cl. 128-173) The invention described herein may be manufactured and use-d by or for the Government of the United States of America for governmental purposes without the payment of any royalties thereon or therefor.
This inventionrelates to improvements in apparatus for effecting subcutaneous and intramuscular injections of medicaments and the like into human beings and animals, and more particularly to improvements for injection without the use of 'a hypodermic needle.
A. recent technique has evolved for subcutaneous injections without the use of a hypodermic needle in which a metered quantity of injectant is projected against the skin at such high pressure and velocity that it penetrates the skin. Such technique is exemplified by the multi-dose injector, manufactured by the R. P. Sherer Company of Detroit, Mich. Such device is quite complicated and expensive and requires an electric motor source for developing the requisite pressure for the injectant gun. In remote regions, where a source of electric power is not available, it therefore becomes unusable. Also, because of its considerable bulk and weight it presents transportation difficulties into such regions.
One of the objects of this invention is to provide a needleless injection device which contains a potential source of gas pressure which may be activated, when desired, and without any specialized power operated apparatus.
Another object is to provide a disposable device of such type for injecting a single metered dose.
A further object is to provide a disposable device of such type which may be constructed so economically that it can be made available to a greater number of users in need of the same.
Still further objects, advantages and salient features will become more apparent from the description to follow, the appended claims and the accompanying drawing in which:
FIG. 1 is an enlarged central section through one form of the invention;
FIGS. 1A and 1B are like sections illustrating various stages of operation;
FIG. 2 is a like section through another form of the invention;
FIG. 2A is a like section of FIG. 2 illustrating the final stage of operation;
FIG. 3 illustrates a modified type of igniter, and
FIG. 4 illustrates a gun which may be optionally employed with any of the various forms of the invention.
Referring now to the drawing, and particularly to FIG. 1, the subject of the invention, in one of its forms, comprises a cylindrical capsule or tube closed at one end by a closure 12 and in which is housed a spherical container 14 which is filled with the desired injectant fluid 16. A head or cap member 18 sealingly closes the opposite end of the capsule to prevent leakage of high pressure gas. The cap may thre-adedly engage the tube, as shown, or otherwise be sealingly secured to it such as by deforming the upper edge of the tube, as by rolling, over the upper edge of the cap. As will be apparent, cements, solders and the like may be employed to sealingly bond the cap to the tube.
A predetermined quantity of propellant powder 20 is disposed within the cylindrical capsule or tube 10, which 3,308,818 Patented Mar. 14, 1967 upon igniting, will produce a predetermined gas pressure within the capsule. Ignition of the propellant may be efiected by a conventional squib 22 containing a bridge wire (not shown) which is energized by electric current from a small portable battery, such as a flash light battery, through a suitable electric lead 24.
The head or cap member is provided with an aperture 25 which leaves a small area of the spherical container wall unsupported and into which the wall may rupture when the injectant container is pressurized. This aperture communicates with a small discharge orifice 26 through which the injectant is expelled at extremely high velocity, sufiicient to effect subcutaneous or intra-muscular penetration of the injectant.
FIG. 1A illustrates the deformation of the injectant container shortly after ignition of the squib at which time the wall has ruptured into aperture 25 and the fluid is being expelled through orifice 26 at high velocity. FIG. 18 illustrates complete deformation or retroversion of the container in which the lower half of the spherical wall has engaged the upper half and the volume of the container has been reduced to its minimum.
The injectant container may be constructed of any material, such as metal or plastic, which is sufliciently ductile to deform, as illustrated, yet not rupture to permit entry of the high pressure gas into the container. In some instances it may be desirable to dispose a ductile heat shield at least adjacent the lower portion of the container to prevent excessive heat transmission to the container wall which might cause rupture by melting or other high temperature failure.
FIG. 2 illustrates a modified form of injectant container 14A which is dome-shaped at one end,-as in the previous embodiment, but is otherwise cylindrical in shape. FIG. 2A illustrates the complete deformation of this container after being pressurized.
FIG. 3 illustrates another form of igriiter in the form of a percussion cap 22A which may be initiated by impact of a firing pin 30.
FIG. 4 is exemplary of a gun" 32 containing an injectant cartridge. Any suitable movable closure 34 may be employed to permit insertion of the cartridge into the gun after which it may be initiated by a trigger 36 which may operate a hammer for the percussion type or operate a switch for the electric squib type. The battery may cOnveniently be housed within the handle of the gun.
Obviously many modifications and variations of the present invention are possible in the light of the above teachings. It is therefore to be understood that within the scope of the appended claims the invention may be practiced otherwise than as specifically described.
What is claimed is:
1. Apparatus for subcutaneous injections of liquid medicaments and the like, comprising;
(a) an outer container adapted to withstand high gas pressure,
(b) a hermetically sealed ductile inner container, containing the medicament,
(c) said inner container having a first portion of its wall supported by said outer container and a second portion adapted to deform into a retroversion contact with the first portion, without rupturing, to thereby reduce its volume to zero,
(d) said first portion of the inner container being unsupported by the outer container over a relatively small area to permit the inner container to rupture,
(e) a nozzle in the outer container communicating with said area through which the medicament may be discharged at a sufiiciently high velocity to eifect subcutaneous injection,
3 (f) a powder type propellant in said first container, the
products of combustion of which are adapted to deform said inner container, and
(g) means for initiating combustion of said propellant.
2. Apparatus in accordance with claim 1 wherein said second container is spherical in shape with a first hemispherical portion supported by said first container and a second hemispherical portion unsupported and adapted to be deformed concavely hemispherical and into contact with the first hemispherical portion.
3. Apparatus in accordance with claim 1 wherein said second container is cylindrical in shape with an unsupported end wall adapted to be deformed concavely and into contact with the supported portion.
4. Apparatus in accordance with claim 1 wherein the means for initiating combustion of said propellant comprises an electrically initiated squib.
5. Apparatus in accordance with claim 1 wherein the means for initiating combustion of said propellant comprises a percussion cap.
References Cited by the Examiner UNITED STATES PATENTS 1,642,950 9/1927 Haas 128265 5 2,151,418 3/1939 Bolte 128265 2,816,544 12/1957 Scherer et al 128-173 3,071,294 1/1963 Galbierz 222541 3,145,712 8/1964 Litz 128173 10 References Cited by the Applicant UNITED STATES PATENTS 2,674,998 4/1954 Boehm.
2,854,925 10/1958 Crockford et al.
2,876,771 3/ 1959 Dunmire. 15 3,023,750 3/1962 Baron.
FOREIGN PATENTS 1,121,237 4/1956 France.
20 RICHARD A. GAUDET, Primary Examiner.
K. L. HOWELL, Assistant Examiner.

Claims (1)

1. APPARATUS FOR SUBCUTANEOUS INJECTIONS OF LIQUID MEDICAMENTS AND THE LIKE, COMPRISING; (A) AN OUTER CONTAINER ADAPTED TO WITHSTAND HIGH GAS PRESSURE, (B) A HERMETICALLY SEALED DUCTILE INNER CONTAINER, CONTAINING THE MEDICAMENT, (C) SAID INNER CONTAINER HAVING A FIRST PORTION OF ITS WALL SUPPORTED BY SAID OUTER CONTAINER AND A SECOND PORTION ADAPTED TO DEFORM INTO A RETROVERSION CONTACT WITH THE FIRST PORTION, WITHOUT RUPTURING, TO THEREBY REDUCE ITS VOLUME TO ZERO, (D) SAID FIRST PORTION OF THE INNER CONTAINER BEING UNSUPPORTED BY THE OUTER CONTAINER OVER A RELATIVELY SMALL AREA TO PERMIT THE INNER CONTAINER TO RUPTURE, (E) A NOZZLE IN THE OUTER CONTAINER COMMUNICATING WITH SAID AREA THROUGH WHICH THE MEDICAMENT MAY BE DISCHARGED AT A SUFFICIENTLY HIGH VELOCITY TO EFFECT SUBCUTANEOUS INJECTION, (F) A POWDER TYPE PROPELLANT IN SAID FIRST CONTAINER, THE PRODUCTS OF COMBUSTION OF WHICH ARE ADAPTED TO DEFORM SAID INNER CONTAINER, AND (G) MEANS FOR INITATING COMBUSTION OF SAID PROPELLANT.
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Cited By (50)

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US3415277A (en) * 1967-03-20 1968-12-10 Thiokol Chemical Corp Ullage control
US3483695A (en) * 1967-04-25 1969-12-16 Charles R Olsen Actuator
US3802430A (en) * 1972-06-30 1974-04-09 L Arnold Disposable pyrotechnically powered injector
US3810655A (en) * 1972-08-21 1974-05-14 Gen Motors Corp Gas generator with liquid phase cooling
USRE28434E (en) * 1967-04-25 1975-05-27 Olsen actuator
US4007691A (en) * 1975-12-23 1977-02-15 The United States Of America As Represented By The Secretary Of The Navy Smoke marker
US4169403A (en) * 1978-08-04 1979-10-02 Hanson Ralph W Bomb circuit disrupting device and method
US4564363A (en) * 1983-07-13 1986-01-14 Smithkline Beckman Corporation Delayed action assembly
US5026343A (en) * 1988-11-21 1991-06-25 Walter Holzer Device for needleless hypodermic injection of medications
US5062834A (en) * 1989-02-24 1991-11-05 Product Development (S.G.Z.) Ltd Device for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate
US5346473A (en) * 1993-02-22 1994-09-13 The United States Of America As Represented By The Department Of Health And Human Services Oxy-hydrogen propelled torpedo for introducing angioplasty guide wire
US5421263A (en) * 1994-03-24 1995-06-06 Raikka Oy Cartridge for spraying a liquid into the barrel of a firearm
US5425706A (en) * 1989-02-24 1995-06-20 S. I. Scientific Innovations Ltd. Dispensing device particularly useful for dispensing nutritional liquids
WO1996020022A1 (en) * 1994-12-23 1996-07-04 Powderject Research Limited Particle delivery
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5643211A (en) * 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5697917A (en) * 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5722953A (en) * 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
EP0853952A1 (en) * 1997-01-17 1998-07-22 Roche Diagnostics GmbH Transdermal injection device
US5800388A (en) * 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5877390A (en) * 1995-12-19 1999-03-02 Canon Kabushiki Kaisha Method for dispersing chemicals and microorganisms into soil using explosives
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5947928A (en) * 1997-06-19 1999-09-07 Mile Creek Capital, Llc Drug delivery system
EP1090651A1 (en) * 1999-10-08 2001-04-11 Snpe Needleless syringe supplied with a trigger activated by friction
US6270473B1 (en) 1995-03-15 2001-08-07 Jettek, Inc. Hypodermic jet injector and disposable ampule
WO2001097880A2 (en) 2000-06-20 2001-12-27 Roche Diagniostics Gmbh Needleless injection device with pyrotechnic drive
DE10057931A1 (en) * 2000-11-22 2002-08-29 Peter Lell Surgical instrument uses gas pressure produced by combustion of an explosive substance to drive a needle, in particular, in the form of a trocar into a human or animal body
WO2003011380A3 (en) * 2001-07-26 2003-05-30 Powderject Res Ltd Silencing device and method for needleless syringe
US20030114789A1 (en) * 2001-12-14 2003-06-19 Hans-Peter Haar Needleless hypodermic injection device
US6726665B1 (en) 1994-08-30 2004-04-27 Pharmacia Aktiebolag Ocular treatment device
US20040220525A1 (en) * 2000-01-07 2004-11-04 Willis John P Injection device
US20060089595A1 (en) * 2003-03-21 2006-04-27 Crossject Needleless injection device comprising means for regulating the gas pressure level in the combustion chamber
US20060216337A1 (en) * 2005-03-28 2006-09-28 Van Laar Kurt D Needeleless medication delivery system
EP1707228A1 (en) * 2005-03-28 2006-10-04 Kurt Daniel Van Laar Patch with needleless injection systems
US20070038175A1 (en) * 2005-08-04 2007-02-15 Kurt Daniel Van Laar Enhanced needleless medication delivery system
US20070241131A1 (en) * 2006-04-17 2007-10-18 The Procter & Gamble Company Preferentially expandable/collapsable container and package therefor
US20090234276A1 (en) * 2004-12-01 2009-09-17 Toles Warren L Needle-free injector
US20110024450A1 (en) * 2008-01-08 2011-02-03 Dispensing Technologies B.V. Composite container and method for manufacturing same ("Multi-Layer Preform")
US20120167393A1 (en) * 2009-09-22 2012-07-05 Koninklijke Philips Electronics N.V. Fluid reservoir for a handheld device for personal care
US9200877B1 (en) * 2012-05-02 2015-12-01 Darren Rubin Biological active bullets, systems, and methods
WO2015197724A1 (en) 2014-06-24 2015-12-30 Lts Lohmann Therapie-Systeme Ag Needleless injection device with double membrane
EP2979714A1 (en) 2014-08-02 2016-02-03 LTS LOHMANN Therapie-Systeme AG Needleless injection device with a membrane
EP3011988A1 (en) 2014-10-22 2016-04-27 LTS LOHMANN Therapie-Systeme AG Needle-free injection device with a gel and a membrane
EP3808391A1 (en) * 2010-11-08 2021-04-21 Aktivax, Inc. Beneficial agent dispenser
CN114616023A (en) * 2019-10-30 2022-06-10 株式会社大赛璐 Multi-point injection patch
EP3870258A4 (en) * 2018-10-23 2022-08-10 AktiVax, Inc. Intranasal pressure drug delivery device
DE102021116399A1 (en) 2021-06-24 2022-12-29 Ruag Ammotec Gmbh Injection cartridge for a needleless injection system
US11607490B2 (en) * 2016-11-01 2023-03-21 Sanofi-Aventis Deutschland Gmbh Volume measuring arrangement

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US2816544A (en) * 1954-07-12 1957-12-17 Scherer Corp R P Hypodermic injector
US2854925A (en) * 1957-07-23 1958-10-07 Palmer Chemical & Equipment Co Projectile for delivery of drugs to animals
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US3023750A (en) * 1959-03-04 1962-03-06 Howard C Baron Self-generating pressure device for infusion administration systems
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