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US3216616A - Syringe with upper and lower bores - Google Patents

Syringe with upper and lower bores Download PDF

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US3216616A
US3216616A US34858864A US3216616A US 3216616 A US3216616 A US 3216616A US 34858864 A US34858864 A US 34858864A US 3216616 A US3216616 A US 3216616A
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bore
plunger
lower
upper
outer
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Jr Homer Blankenship
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Jr Homer Blankenship
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/021Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0231Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having several coaxial pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525Dosing
    • A61M5/31531Microsyringes, e.g. having piston bore diameter close or equal to needle shaft diameter

Description

1965 H. BLANKENSHIP, JR 3,216,616

SYRINGE WITH UPPER AND LOWER BORES Filed March 2. 1964 Q I i i gm V x7007 e," .5/0/7A'e/7Jfi 0, d/z

INVENTOR.

BY fig 5 2 ATTUR/VEVJ United States Patent 3,216,616 SYRINGE WITH UPPER AND LOWER BORES Homer Blankenship, Jr., 3601 White Oak Drive, Houston, Tex. Filed Mar. 2, 1964, Ser. No. 348,588 7 Claims. (Cl. 222-47) This invention relates to new and useful improvements in syringes.

An object of this invention is to provide a new and improved syringe from which accurately measured quantities of fluid may be dispensed by a plunger displacing same in a syringe tube having a calibrated 'bore, and wherein such bore is formed without grinding to dimension, thereby reducing the manufacturing cost and facilitating interchangeability of syringe tubes and plungers.

Another object of this invention is to provide a new and improved syringe having a body with at least two different internal bore dameters, and also having a plunger for each such bore.

A particular object of this invention is to provide a new and improved syringe wherein mixing and blending of two difierent fluids may be effected within the syringe body in measured quantities.

A further object of this invention is to provide a new and improved syringe having a syringe body with two different internal diameter bores, each of which is calibrated, and also having plunger means for drawing different measured quantities of fluids into such bores for mixing and/or blending in desired proportions and for thereafter discharging such mixed and/or blended fluids in measured quantity from the syringe.

Still another object of this invention is to provide a new and improved syringe having a body with a lower bore and an upper bore, wherein the upper bore is of a larger diameter than the lower bore, and wherein an outer plunger is slidable in the upper bore and an inner plunger is slid'able in the lower bore, such outer plunger sealing off the lower bore at its upper end to enable the inner plunger to discharge a measured quantity of fluid from the lower bore even though the inner plunger does not have a precision fit within the lower bore.

A specific object of this invention is to provide a new and improved syringe having a body made of glass or similar transparent material, with a two-part plunger therein, one part of which is made of plastic or other material capable of forming a seal in the bore of the body, and the second part of which is formed of metal wire or similar material for serving as a plunger.

The preferred embodiment of this invention will be described hereinafter, together with other features thereof, and additional objects will become evident from such description.

The invention will be more readily understood from a reading of the following specification and by reference to the accompanying drawings forming a part thereof, wherein an example of the invention is shown, and wherein:

FIG. 1 is an elevation of the syringe of this invention in the normal assembled condition; and

FIG. 2 is an exploded view, partly in elevation and partly in section, illustrating the principal components of the syringe of this invention in a disassembled condition.

In the drawings, the letter S designates generally the syringe -of this invention which includes a tubular body 10 formed of glass or other similar material, preferably transparent. Such body 10 is provided with an upper bore 11 and a lower bore 12. An outer plunger is disposed for movement in the upper bore 11 for drawing fluid into the bores 11 and 12 and for performing other functions, as will be An inner plunger 20 is adapted to be positioned within the bore or longitudinal opening of the outer plunger 15, and its lower portion serves to discharge fluid in predetermined amounts from the lower bore 12 through a needle 25, as will be more fully explained.

Considering the invention more in detail, the body 10 is preferably precision bore glass tubing in which the glass is shrunk over a mandrel to obtain the prescribed inner dimensions. As will be more evident hereinafter, one of the advantages of the present invention resides in the fact that the bores 10 and 12 do not have to be precision ground, thereby eliminating an expensive grinding operation heretofore considered necessary in most types of syringes. By way of example, the inside diameter of the lower bore 12 may be 0.0206 inch plus or minus 0.0002 inch. Such tolerances are obtained with the precision bore tubing without the necessity for grinding. The upper bore 11 may have, by way of example, an inside diameter of 0.2500 inch plus or minus 0.0002 inch. Such dimensions can also be obtained with the precision bore tubing and without the necessity for grinding.

The upper bore 11 and the inner bore 12 are joined by an internal tapered or inclined wall surface 14 which serves as a seating or sealing surface in conjunction with the outer plunger 15, as will be described.

For convenience in handling, a flange 10a is preferably provided on the body at its upper end as illustrated. The needle 25 is secured to the lower end of the body 10, preferably by inserting same within a suitable enlarged opening 12a at the lower end of the inner bore 12'. An epoxy resin or other adhesive suitable for bonding the metallic needle 25 to the glass body 10 is preferred for retaining the needle 25 in an attached position with'respect to the body 10. It is noted that the needle 25 is shown with a reduced diameter point 25a, but it will be understood that various other types of needles may be employed, depending upon the particular us The needle 25 is of course hollow throughout its length so as to admit fluid into the bores 12 and 11 and to also permit the discharge of fluid therefrom.

The outer plunger 15 is preferablymade of polytetrafiuoroethylene, sold under the trademark Teflon, which material is especially suitable since it provides for substantially frictionless movement within the upper bore 11 while also maintaining effective seals as Will be more evident hereinafter. In the usual case, with the bore 11 of the internal diameter heretofore specified the external explained in detail.

diameter of the outer plunger 15 is 0.2497 inch.

The outer plunger 15 has an internal longitudinal passage or opening 16, which is reduced in. diameter at its lower portion 16a.

An annular ring indicator 17 is adhered or otherwise attached to the external surfaceof the outer plunger 15 near its lower end, but above its lower tapered surface 15a. Such ring indicator 17 may be made of black rubber or similar material so that it is visible when adjacent the graduations or volume indicia on the external surface of the body 10 adjacent the upper bore 11 as best seen in FIG. 1.

The taper or inclination of the lower surface 15a corresponds closely to the taper or inclination of the seating surface 14 within the body 10. Preferably, the angle of the tapered surface 15a extending upwardly and outwardly is slightly greater than the angle of inclination of the surface 14 for more effective sealing contact when the surfaces 15a and 14 are brought into engagement.

A removable nut 18 having internal threads 18a is provided at the upper end 15b of the plunger 15, which upper end 15b is also threaded externally for receiving the internal threads 18a of the nut 18. Ordinarily the threads 18a and 15b are tapered downwardly and outwardly so 'that as the nut 18 is threaded downwardly on the plunger example of 0.020 inch so that item freely move longitudinally within the inner bore 12.

The upper portion 22 of the inner plunger 20 is made of brass or a similar material and it has an increased diameter or width as compared to the wire 21 to provide for increased strength-during longitudinal movements of the inner plunger 20. A handle or head 23 is secured to the upperplunger portion 22 by welding, brazing or other suitable method so that the handle 23 becomes an integral part of the inner plunger '20. It should also be noted that the lower wire -or plunger 21 is attached by brazing, bonding or other-suitable method to the upper plunger portion 22 so that such portions 21 and 22 become integral for operating purposes. In some instances, it will be understood that the-entire inner plunger '20 may be made of a single metal or other material. As illustrated in the :;drawings, the upper l'brass rod section 22 has a diameter of inch so that it is of substantial thickness as compared :to the lower plunger 21. The inner passage or opening 16 of the outer plunger 15 has an opening sufficient for the upper portion 22 of the inner plunger 20. The reduced diameter opening 16a is of a size which is adequate for the passage of the lower plunger wire 21 therethrough. Preferably, the external surface of the wire 21 should have a diameter which is substantially the same as the internal diameter of the lower opening 160 for sealing purposes. The diameter of the opening 16 above the lower opening 16:: should be close enough to the diameter of .the plunger portion 22 so that when the nut 18 is :rotated and is moved downwardly with respect to the outer plunger 15, a compression or inward radial movement .of the material of the outer plunger 15 causes an-effective seal with the plunger portion 22 to prevent the escape of gas .or other fluids .between the plunger 15 and the plunger section 22, as will be further noted herein.

As illustrated in FIG. 1, the lower bore 12 is graduated or calibrated for microliters, while the upper bore 11 is graduated or calibrated for 1 milliliter. It will be understood that the volumes in each of the bores 11 and 12 may be varied by changing the dimensions thereof proportionately. For example, the lower bore 12 may be graduated for 1 microliter, 10 microliters, 20 microliters, 50 microliters or any similar relatively small quantities. The upper bore 11 may begraduated and calibrated for 1 milliliter, 2milliliters, or even more.

Because of the construction of the syringe of this invention, withthe two volume sections, it has great versatility and many uses.

.By way of example, the lower bore 12 may be utilized by itself in some instances for obtaining predetermined sample quantities of liquid. Thus, the needle 25 is injected into the container .having the liquid to be sampled or tested, with the plunger at its lowermost position. The lower plunger wire 21may be in its lowermost position where it may be drawn upwardly so that its lower end is withdrawn into the opening 16a. Then, the outer plunger 15 and the innerplunger are moved upwardly together relative to the body 10 to draw the liquid into the inner lower bore 12 until an adequate amount of liquid has been drawn in so as to fill the lower bore 12 and also a portion of the upper bore 11. The outer plunger 15 together with the inner plunger 20 may be moved back and forth to purge the inner bore 12 and also the upper bore 11 of air or other gas when filling the tube or body 10 with a liquid.

In any event, any air or gas which is present in the syringe .is discharged by forcing :the .plungers 15 and .20

downwardly so as to leave the lower bore 12 completely filled with the fluid. After the outer plunger 15 and the inner plunger 20 are forced downwardly together to cause the tapered surface 15a to engage the surface 14, the inner plunger 20 is moved downwardly relative to the outer plunger 15 until the lower end 21a'of the lower plunger wire 21 is at the uppermost mark having the indicia 16 for 10 microliters in FIG. 1. If 10 microliters are to be discharged or dispensed, the inner plunger 20 is then forced downwardly so that the lower end 21a moves from the indicia 10 down to the indicia 0 within the lower bore 12. If a lesser amount of the fluid is to be measured out, such as seven microliters, the measured discharge may start at the time the lower wire 21a is at the indicia 7 for 7 microliters and then the discharge may continue until the lower end 21a reaches the 0 indicia mark. Any other predetermined quantities may of course be discharged with the lower wire 21 as will be understood.

In some instances, it is desirable to mix and/or blend two or more liquids in predetermined quantities withinthe body 10 of the syringe S. For example, for dilution purposes, one fluid may be drawn into the syringe by pulling the outer plunger 15 and in the inner plunger 20 together upwardly from the lowermost position of the outer plunger 15 so as to draw the fluid into the lower bore 12. A suflicient amount of fluid may be drawn into the bores 11 and 12 to partially fill the upper bore 11, and then the outer plunger 15 together with the inner plunger 20 may be forced downwardly to force any gas or air out of the bores 11 and 12, leaving only the liquid. The outer plunger 15 may then be seated with the lower tapered surface 15a in contact with the tapered surface 14, and the lower end of the wire 21a may be moved downwardly until it is aligned with the uppermost mark indicated by the indicia 10 in FIG. 1. The user then knows that he has a measured quantity of 10 mircoliters within the lower bore 12. Thereafter, the outer plunger 15, together with the inner plunger 20, are pulled upwardly to draw into the bores 11 and 12 a diluent or other liquid to be mixed with the first liquid already in the bore 12. The quantity of liquid which is drawn into the bores 11 and 12 is indicated bythe graduation marks on the external surface of the bore 10 in proximity to the upper bore 11, which as shown in FIG. 1 runs from 0 to IML (one milliliter). The two liquids are actually mixed together by the drawing of the second liquid into the syringe and the mixture is in a known proportion due to the known amounts of the liquids which have been drawn into the syringe body 10. Therefore, such liquids are thereby mixed and blended and may be discharged as a mixed or diluted fluid. The indicia band 17 becomes aligned with the various graduation or calibration marks on the upper bore 11 in the preferred form of the invention.

In some instances, it is desirable to use the syringe S for gas samples. It is important in such cases to prevent any escape of gas through the longitudinal opening 16. Normally, the sealing contact between the wall of the opening 16a and the wire 21 is suflicient to prevent liquid from passing therebetween, but gases may escapetherebetween in some cases. Therefore, the nut 18 is tightened or rotated so as to move downwardly on the outer plunger 15 to form a seal with the upper portion 22 of the inner plunger 20. Such seal is effective to prevent the passage of gases between the internal wall of the longitudinal passage 16 and the external surface of the nod 22. It will be understood that the gases may be mixed and/ or blended in the same manner as heretofore described in connection with the liquids, although a purging of gas or air within the syringe prior to the introduction of the gas being tested or sampled is essential for accurate results. Therefore, a reciprocation of the plungers 15 and 20 within the body 10 while the needle 25 is within the gas to be sampled is important. For example, the needle 25 may be injected into a balloon having the gas to be sampled and the gas may be drawn into the syringe S in a quantity greater than intended to be discharged for the sample. Then the needle 25 may be withdrawn and the plungers 1S and 20 may be forced to their lowermost positions, evacuating all except a small amount of the gas which might remain at the lower end of the bore 12. This process can be repeated until it is absolutely certain that the only possible gas within the syringe is the gas to be sampled. Then the sample of the gas is obtained by again inserting the needle 25 into the balloon or other source of the gas and the amount of the sample to be used is drawn into the syringe. All of the gas, except that which is to be dispensed in the measured quantity, is discharged from the bores of the syringe body 19. A second sample of another gas may be then drawn into the bores of the syringe S and mixed or blended in predetermined quantities to get a desired dilution or other blending.

It will be understood that the invention disclosed herein has great versatility and many uses, and the foregoing uses are merely illustrative. Since the wire 21 is a standard wire and the bore 12 is made by the precision shrinking process heretofore described, without the necessity for grinding, the syringe bodies and the plungers and may be standardized and interchangeable, which is not the case if precision grinding is required in the bore 12. Also, it will be understood that when the tapered surface 15a seats upon the surface 14, a seal is obtained between the external surface of the plunger 15 and the internal surface of the bore 11 to prevent any fluid from flowing around the plunger 15. The tapered surface 15a also tends to force the inner wall of the opening 16a into tight sealing engagement with the wire 21 to prevent any escape of fluid upwardly along the rod 21 through the opening 16a. When the seal has been established, the wire 21 then moves down and as it moves downwardly from the lower end of the plunger 15, it displaces fluid in accordance with the cross-sectional area of the wire 21 and the stroke of such wire. Therefore, even though there is a space between the wire 21 and the internal bore 12, a predetermined quantity of fluid is discharged by the wire 21 and such predetermined quantity is in accordance with the calibrations on the side of the body 10 adjacent the bore 12 as illustrated in FIG. 1.

Also, when taking gas samples, it is desirable to provide a gas-tight seal around the rod 22 by tightening the nut 18, as previously explained, so that the gas is prevented from escaping between the inner rod 22 and the wall of the passage 16 in the outer plunger 15.

Various other modifications and changes will occur to those skilled in the art. It is understood that the particular materials disclosed herein are merely by way of example and ar not intended to be limiting.

The foregoing disclosure and description of the invention is illustrative and explanatory thereof and various changes in the size, shape and materials, as well as in the details of the illustrated construction, may be made within the scope of the appended claims without departing from the spirit of the invention.

What is claimed is:

1. A syringe, comprising:

(a) a transparent tubular body having a lower bore and an upper bore,

(b) said body having volume marks for indicating variou volumes within each of said bores,

(c) said upper bore having a larger diameter than said lower bore,

((1) an outer plunger disposed in said upper bore for longitudinal movement therein,

(e) said outer plunger is visible through the wall of said upper bore,

(f) said outer plunger having a longitudinal opening therethrough,

(g) an inner plunger extending through said longitudi nal opening of said outer plunger and movable longitudinally thereto and into said lower bore for discharging a predetermined quantity of fluid from said lower bore, and

(h) said inner plunger being visible through the wall of said lower bore.

2. A syringe, comprising:

(a) a glass body having a lower bore and an upper bore,

(b) said upper bore having a larger diameter than said lower bore,

('0) a polytetrafluoroethylene outer plunger disposed in said upper bore for longitudinal movement therein,

(d) said outer plunger having a longitudinal opening therethrough, and

(e) a metal inner plunger extending through said longitudinal opening of said outer plunger and movable longitudinally relative thereto and into said lower bore for discharging a predetermined quantity of fluid from said lower bore.

3. A syringe, comprising:

(a) a tubular body having a lower bore and an upper bore,

(b) said upper bore having a larger diameter than said lower bore,

(c) an outer plunger disposed in said upper bore for longitudinal movement therein,

(d) said outer plunger having a longitudinal opening therethrough,

(e) said outer plunger having a sealing section,

(f) said tubular body having a seating surface between said upper bore and said lower bore adapted to be engaged by said sealing section for sealing off said lower bore from said upper bore,

(g) an inner plunger extending through said longitudL nal opening of said outer plunger and movable longitu-dinally relative thereto and into said lower bore for discharging a predetermined quantity of fluid from said lower bore, and

(h) said inner plunger having a diameter enough smaller than the lower bore to avoid forming a seal therebetween, whereby the volume of fluid discharged by said inner plunger is a product of the cross-sectional area and the longitudinal stroke of said inner plunger.

4. A syringe, comprising:

(a1)J a tubular body having a lower bore and an upper ore,

(b) said upper bore having a larger diameter than said lower bore,

(c) an outer plunger disposed in said upper bore for longitudinal movement therein,

(d) said outer plunger having a longitudinal opening therethrough,

(e) siaid outer plunger having a lower external tapered (f) said tubular body having an annular inclined surface between said upper bore and said lower bore adapted to be engaged by said tapered end of said outer plunger for forming a fluid-tight seal therewith, and

(g) an inner plunger extending through said longitudinal opening of said outer plunger and movable longitudinally relative thereto and into said lower bore for discharging a predetermined quantity of fluid from said lower bore,

(h) said outer plunger sealing around said inner plunger to provide a fluid-tight seal therebetween.

5. A syringe, comprising:

(a?) a tubular body having a lower bore and an upper ore,

(b) said upper bore having a larger diameter than said lower bore,

(c) an outer plunger disposed in said upper bore for longitudinal movement therein,

(d) said outer plunger having a longitudinal opening therethrough,

(e) an inner plunger comprising an upper pusher rod connected to a lower plunger wire, said wire extending through the lower end of said outer plunger and into said lower bore for discharging fluid from said lower bore, and

(f) said upper pusher rod providing increased strength as compared to said wire to prevent breakage or bending of the lower plunger wire in use.

6. A syringe, comprising:

(a) atubular body having :a lower bore and an upper bore,

(b) said upper bore having, a larger diameter than said lower bore,

(c) an outer plunger disposed in said upper bore for longitudinal movement therein,

((1) said outer plunger having a longitudinal opening therethrough,

(e) an inner plunger extending through said longitudinal opening of said outer plunger and movable longitudinally relative thereto and into said lower bore for discharging a predetermined quantity of fluid from said lower bore, and

(f) means for compressing the upper end of said outer plunger into sealing engagement with said inner plunger to prevent the escape of gas or other fluid through said longitudinal opening in said outer plunger.

7. AsyIing'e, comprising:

(a) a tubular body having a lower bore and an upper bore,

(b) said upper bore having a larger diameter than said lower bore,

(c) an outer plunger disposed in said upper bore for longitudinal movement therein,

((1) ,said outer plunger having a longitudinal opening therethrough,

(e) an inner plunger extending through said longitudinal opening of said outer plunger and movable longitudinally relative thereto and into said lower bore for discharging a predetermined quantity of fluid from said lower bore,

(f) the upper end of said outer plunger being formed of a compressible material and having external threads formed thereon, and

(g) a nut threaded on said external threads for slightly compressing the upper end of said outer plunger to form a fluid-tight seal with said inner plunger to prevent the escape of gas or other fluid through said longitudinal opening in said outer plunger.

References Cited by the Examiner UNITED STATES PATENTS 1,612,996 1/27 Waagbo 222-386 X 1,693,261 11/28 Sweetland.

2,841,145 7/58 Epps.

3,140,078 7/64 Krahe et al 222--386 X 3,153,496 10/64 Johnson 222--386 LOUIS J. DEMBO, Primary Examiner.

CHARLES R. CARTER, Examiner.

Claims (1)

1. A SYRINGE, COMPRISING: (A) A TRANSPARENT TUBULAR BODY HAVING A LOWER BORE AND AN UPPER BORE, (B) SAID BODY HAVING VOLUME MARKS FOR INDICATING VARIOUS VOLUMES WITHIN EACH OF SAID BORES, (C) SAID UPPER BORE HAVING A LARGER DIAMETER THAN SAID LOWER BORE, (D) AN OUTER PLUNGER DISPOSED IN SAID UPPER BORE FOR LONGITUDINAL MOVEMENT THEREIN, (E) SAID OUTER PLUNGER IS VISIBLE THROUGH THE WALL OF SAID UPPER BORE, (F) SAID OUTER PLUNGER HAVING A LONGITUDINAL OPENING THERETHROUGH, (G) AN INNER PLUNGER EXTENDING THROUGH SAID LONGITUDINAL OPENING OF SAID OUTER PLUNGER AND MOVABLE LONGITUDINALLY THERETO AND INTO SAID LOWER BORE FOR DISCHARGING A PREDETERMINED QUANTITY OF FLUID FROM SAID LOWER BORE, AND (H) SAID INNER PLUNGER BEING VISIBLE THROUGH THE WALL OF SAID LOWER BORE.
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Cited By (45)

* Cited by examiner, † Cited by third party
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US3306502A (en) * 1965-04-28 1967-02-28 Prec Sampling Corp Apparatus for injection of fluids
US3322307A (en) * 1964-08-25 1967-05-30 Fraser Frank Devices for supplying materials
US3366286A (en) * 1965-10-23 1968-01-30 Garth A. Kloehn High precision syringe
US3401692A (en) * 1964-06-26 1968-09-17 Micro Tek Instr Corp Syringe provided with a lateral vent and having high compression seals within the syringe bore
US3552623A (en) * 1968-03-13 1971-01-05 Beckman Instruments Inc Multiple sample applicator
US3921864A (en) * 1972-09-22 1975-11-25 Dawes Ernest Frederick Syringes for making precision volume measurements
US3923207A (en) * 1973-03-29 1975-12-02 Jintan Terumo Co Microliter syringe for dispensing small, accurately measured quantities of fluid specimens
FR2301818A1 (en) * 1975-02-18 1976-09-17 Risch Gerhard Apparatus gradual Levy liquids, in particular for diluting liquid samples
US4133304A (en) * 1977-04-29 1979-01-09 Emde Corporation Syringe-like apparatus with removable capillary cartridge
US4135510A (en) * 1977-02-09 1979-01-23 Schering Corporation Syringe barrel
FR2414221A1 (en) * 1978-01-10 1979-08-03 Suovaniemi Finnpipette An apparatus providing the mixing and accurate dispensing of liquids
EP0009013A1 (en) * 1978-09-04 1980-03-19 Lkb Clinicon Aktiebolag A pipetting and dosing device
US4384581A (en) * 1980-01-17 1983-05-24 Becton, Dickinson And Company Microsyringe
US4404862A (en) * 1981-11-02 1983-09-20 Dynatech Precision Sampling Corporation Microdispensing springs with a needle in a tubular extension
US4615341A (en) * 1981-06-18 1986-10-07 Syringe Industries, Inc. Syringe device for physiological fluid sampling
WO1988003778A1 (en) * 1986-11-27 1988-06-02 Jacques Chaoulli Apparatus for taking and injecting liquids
US4767407A (en) * 1986-07-14 1988-08-30 Foran Scot J Hypodermic needle, catheter and method
US4795444A (en) * 1986-05-02 1989-01-03 Sunstar Kabushiki Kaisha Syringe
EP0545324A1 (en) * 1991-11-29 1993-06-09 Sergej Mikhailovic Masurik Injection syringe
US5593393A (en) * 1995-09-07 1997-01-14 Trudell; Roger J. Lacrimal irrigating cannula
US20030012080A1 (en) * 2001-07-16 2003-01-16 Coffeen Jared P. Bone cement mixing and delivery device for injection and method thereof
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US8992541B2 (en) 2003-03-14 2015-03-31 DePuy Synthes Products, LLC Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
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US8956368B2 (en) 2003-06-17 2015-02-17 DePuy Synthes Products, LLC Methods, materials and apparatus for treating bone and other tissue
US9504508B2 (en) 2003-06-17 2016-11-29 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
US8361078B2 (en) 2003-06-17 2013-01-29 Depuy Spine, Inc. Methods, materials and apparatus for treating bone and other tissue
US8540722B2 (en) 2003-06-17 2013-09-24 DePuy Synthes Products, LLC Methods, materials and apparatus for treating bone and other tissue
US7112205B2 (en) 2003-06-17 2006-09-26 Boston Scientific Scimed, Inc. Apparatus and methods for delivering compounds into vertebrae for vertebroplasty
US8579908B2 (en) 2003-09-26 2013-11-12 DePuy Synthes Products, LLC. Device for delivering viscous material
US9750840B2 (en) 2004-03-21 2017-09-05 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
US8809418B2 (en) 2004-03-21 2014-08-19 DePuy Synthes Products, LLC Methods, materials and apparatus for treating bone and other tissue
US8415407B2 (en) 2004-03-21 2013-04-09 Depuy Spine, Inc. Methods, materials, and apparatus for treating bone and other tissue
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