US3185626A - Tablet coating method - Google Patents
Tablet coating method Download PDFInfo
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- US3185626A US3185626A US263100A US26310063A US3185626A US 3185626 A US3185626 A US 3185626A US 263100 A US263100 A US 263100A US 26310063 A US26310063 A US 26310063A US 3185626 A US3185626 A US 3185626A
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- United States
- Prior art keywords
- tablets
- tablet
- syrup
- coating
- sucrose
- Prior art date
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- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims description 21
- 238000009492 tablet coating Methods 0.000 title description 2
- 239000002700 tablet coating Substances 0.000 title description 2
- 239000011248 coating agent Substances 0.000 claims description 10
- 238000000576 coating method Methods 0.000 claims description 10
- 239000000049 pigment Substances 0.000 claims description 7
- 231100000252 nontoxic Toxicity 0.000 claims description 5
- 230000003000 nontoxic effect Effects 0.000 claims description 5
- 239000003826 tablet Substances 0.000 description 34
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 22
- 239000006188 syrup Substances 0.000 description 16
- 235000020357 syrup Nutrition 0.000 description 16
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 12
- 229930006000 Sucrose Natural products 0.000 description 12
- 239000005720 sucrose Substances 0.000 description 11
- 239000004408 titanium dioxide Substances 0.000 description 11
- 239000000975 dye Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 6
- 238000004040 coloring Methods 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000009498 subcoating Methods 0.000 description 5
- 239000003086 colorant Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 238000009499 grossing Methods 0.000 description 3
- 235000013980 iron oxide Nutrition 0.000 description 3
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- XCWPUUGSGHNIDZ-UHFFFAOYSA-N Oxypertine Chemical compound C1=2C=C(OC)C(OC)=CC=2NC(C)=C1CCN(CC1)CCN1C1=CC=CC=C1 XCWPUUGSGHNIDZ-UHFFFAOYSA-N 0.000 description 2
- 229940067573 brown iron oxide Drugs 0.000 description 2
- 239000008199 coating composition Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000009501 film coating Methods 0.000 description 2
- 239000007888 film coating Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229960002841 oxypertine Drugs 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 2
- 238000009495 sugar coating Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SXLHPBDGZHWKSX-UHFFFAOYSA-N 1-(5-amino-2-hydroxyphenyl)ethanone Chemical compound CC(=O)C1=CC(N)=CC=C1O SXLHPBDGZHWKSX-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 241000220479 Acacia Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 229920001800 Shellac Polymers 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229920002494 Zein Polymers 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 1
- ONTQJDKFANPPKK-UHFFFAOYSA-L chembl3185981 Chemical compound [Na+].[Na+].CC1=CC(C)=C(S([O-])(=O)=O)C=C1N=NC1=CC(S([O-])(=O)=O)=C(C=CC=C2)C2=C1O ONTQJDKFANPPKK-UHFFFAOYSA-L 0.000 description 1
- 238000009500 colour coating Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 229940075482 d & c green 5 Drugs 0.000 description 1
- 239000003866 digestant Substances 0.000 description 1
- FPAYXBWMYIMERV-UHFFFAOYSA-L disodium;5-methyl-2-[[4-(4-methyl-2-sulfonatoanilino)-9,10-dioxoanthracen-1-yl]amino]benzenesulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC(C)=CC=C1NC(C=1C(=O)C2=CC=CC=C2C(=O)C=11)=CC=C1NC1=CC=C(C)C=C1S([O-])(=O)=O FPAYXBWMYIMERV-UHFFFAOYSA-L 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 229940057915 fd&c red no. 4 Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229940105623 neo-synephrine Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 229960001802 phenylephrine Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 235000019237 ponceau SX Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- -1 that is Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
Definitions
- This invention relates to tablets and other individual dosage forms. More particularly the invention is concerned with an economical, time-saving process for sugar coating core tablets.
- Tablet coating is an old art in which traditional methods have remained essentially unchanged although in recent years some steps have been made toward reducing the tedious and time-consuming operation.
- a tablet or compressed pellet is sized with a water repellent resin such as shellac or zein and the resultant tablet 0r pellet is then subcoated with several coats of a material such as gelatin or acacia along with subcoating powders designed for dusting the subcoats.
- the subcoating operation although time consuming and expensive has been considered necessary in order to round and shape the tablet preparatory to applying a sugar coating with or without added coloring.
- the film coating procedures suffer from a number of disadvantages which in certain instances outweigh the time-saving advantages.
- the filmforming materials being organic in nature require the use of organic solvents, e.g., alcohol, acetone, ether etc., which are flammable and toxic. It is therefore necessary to carry out the process in explosion-proof equipment with provision for adequate ventilation and exhaust.
- core tablets that is, tablets which may be sealed, sized or enteric coated but not rounded, are sugar coated in one-quarter to one-third the time required by any previously known method. Utilization of the compositions and process of the invention greatly reduces the operating time by eliminating completely subcoats and smoothing coats hitherto believed necessary.
- a color either water-soluble or waterinsoluble, can be incorporated at any stage to give a stable, pharmaceutically elegant finished tablet for which the color is reproducible from batch to batch or operator to operator. There is no necessity for subcoating the rough core tablet or applying smoothing coats yet the finished tablet has stability upon aging, resistance to cracking during sudden temperature changes and a pleasing appearance 7O comparable with tablets made by conventional procedures.
- compositions useful in the process of the invention are comprised of an adhesive aqueous suspending medium such as a gelatin solution or preferably a syrup solution and an opaque non-toxic, pharmaceutically acceptable water insoluble pigment as for example titanium dioxide, iron oxide, barium sulfate and calcium carbonate, and if desired a non-toxic dye of either the water-soluble or water-insoluble type.
- an adhesive aqueous suspending medium such as a gelatin solution or preferably a syrup solution
- an opaque non-toxic, pharmaceutically acceptable water insoluble pigment as for example titanium dioxide, iron oxide, barium sulfate and calcium carbonate, and if desired a non-toxic dye of either the water-soluble or water-insoluble type.
- the aqueous suspending medium is preferably a syrup solution, e.g., an aqueous sugar solution such as an aqueous solution of glucose, lactose, maltose or sucrose.
- a syrup solution e.g., an aqueous sugar solution such as an aqueous solution of glucose, lactose, maltose or sucrose.
- the preferred syrup or sugar solution is a sucrose solution although other sugar derivatives such as mannitol and sorbitol can be used.
- compositions useful in carrying out the improved process can, if desired, contain coloring materials which are any of the non-toxic dyes, lakes and pigments which have been certified for use in the food, drug and cosmetic industries.
- coloring materials which are any of the non-toxic dyes, lakes and pigments which have been certified for use in the food, drug and cosmetic industries.
- water-soluble dyes as illustrated by PD & C Yellow No. 5
- water-insoluble dyes and lakes as illustrated by .D & C Green No. 5
- pigments as illustrated by yellow, brown, red and black iron oxides, titanium dioxide and barium sulfate are suitable as colorants.
- the method of coating core tablets in accordance with the invention comprises forming the syrup or sugar solution in which is suspended the opacifying material by the use of suitable mixing equipment. The suspension is then added to core tablets in a rotating coating pan and the appropriate number of coats applied with air drying after each coat. At any stage colors of the type described above can be added if desired by adding the appropiate color to the syrup and applying the number of coats necessary to give the desired coloring.
- Example 1 Coating suspensions incorporating various dyes were prepared as follows:
- Titanium dioxide N.F. 7.20
- Titanium dioxide N.F. 7.20
- Titanium dioxide N.F. 7.20
- Titanium dioxide N.F. 7.20
- Titanium dioxide N.F. 7.20
- the above suspension was applied to a run of sized, unrounded oxypertine tablets rotating in a coating pan.
- a total of 40 mg. per tablet of the coating composition was applied in about two and one-half hours to give a white sugar coated tablet equal in quality to oxypertine tablets coated in the conventional in five hours.
- a suspension of the above ingredients was applied to a run of size, unrounded pancreatin-containing digestant tablets sold under the trademark Doxegest rotating in a coating pan.
- Application of the coating composition required about two and one-half hours and the resultant brown tablet was comparable to subcoated Doxegest tablets and required about one-third the time.
- a suspension of the above ingredients was applied to a run of sized, unrounded cold tablets containing phenylephrine sold under the trademark Neosynephrine, acetyl p-aminophenol and vitamin C rotating in a coating pan.
- a total of 125 mg. per tablet was applied in about two and one-half hours.
- the yellow tablet thus obtained was equal in quality to sized, unrounded cold tablets coated in the conventional manner in six hours.
- the pigment is selected from the group consisting of titanium dioxide, calicum carbonate, barium sulfate and iron oxide.
- aqueous suspending medium comprises a sucrose solution containing titanium dioxide and a colorant
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Description
United States Patent 3,185,626 TABLET CGATING METHOD Claude W. Baker, Albany, N.Y., assigner to Sterling Drug Inc, New York, N.Y., a corporation of Delaware No Drawing. Filed Mar. 6, 1963, Ser. No. 263,100
5 Claims. (Cl. 167--82) This invention relates to tablets and other individual dosage forms. More particularly the invention is concerned with an economical, time-saving process for sugar coating core tablets.
Tablet coating is an old art in which traditional methods have remained essentially unchanged although in recent years some steps have been made toward reducing the tedious and time-consuming operation. Thus, a tablet or compressed pellet is sized with a water repellent resin such as shellac or zein and the resultant tablet 0r pellet is then subcoated with several coats of a material such as gelatin or acacia along with subcoating powders designed for dusting the subcoats. The subcoating operation although time consuming and expensive has been considered necessary in order to round and shape the tablet preparatory to applying a sugar coating with or without added coloring. After further finishing and polishing there is obtained a pharmaceutically elegant tablet but the inordinate amount of time required in the application and drying of the numerous coats including subcoating, color coating and smoothing coat maks the production of such tablets quite expensive.
In comparatively recent times various film coating procedures have been introduced and these methods have materailly reduced the time required to prepare a finished tablet. However, the film coating procedures suffer from a number of disadvantages which in certain instances outweigh the time-saving advantages. For example, the filmforming materials being organic in nature require the use of organic solvents, e.g., alcohol, acetone, ether etc., which are flammable and toxic. It is therefore necessary to carry out the process in explosion-proof equipment with provision for adequate ventilation and exhaust.
Further complications to the well-known tabletting procedures are introduced when it is desired to color the tablet for purposes of distinctiveness or identification. For many years only dyes of the soluble type were used and this necessarily limited the number and range of colors that could be used. In recent times insoluble dyes or lakes have been incorporated into coloring compositions by the use of surfactants to maintain the dyes or lakes in suspension and more recently it has been found that the surfactant was unnecessary. These improvements materially reduced the operating time for coloring solids but the time-consuming subcoating of the tablets was still carried out.
According to the present invention core tablets, that is, tablets which may be sealed, sized or enteric coated but not rounded, are sugar coated in one-quarter to one-third the time required by any previously known method. Utilization of the compositions and process of the invention greatly reduces the operating time by eliminating completely subcoats and smoothing coats hitherto believed necessary.
Additionally, a color, either water-soluble or waterinsoluble, can be incorporated at any stage to give a stable, pharmaceutically elegant finished tablet for which the color is reproducible from batch to batch or operator to operator. There is no necessity for subcoating the rough core tablet or applying smoothing coats yet the finished tablet has stability upon aging, resistance to cracking during sudden temperature changes and a pleasing appearance 7O comparable with tablets made by conventional procedures.
Patented May 25, 1965 The compositions useful in the process of the invention are comprised of an adhesive aqueous suspending medium such as a gelatin solution or preferably a syrup solution and an opaque non-toxic, pharmaceutically acceptable water insoluble pigment as for example titanium dioxide, iron oxide, barium sulfate and calcium carbonate, and if desired a non-toxic dye of either the water-soluble or water-insoluble type.
The aqueous suspending medium is preferably a syrup solution, e.g., an aqueous sugar solution such as an aqueous solution of glucose, lactose, maltose or sucrose. The preferred syrup or sugar solution is a sucrose solution although other sugar derivatives such as mannitol and sorbitol can be used.
The compositions useful in carrying out the improved process can, if desired, contain coloring materials which are any of the non-toxic dyes, lakes and pigments which have been certified for use in the food, drug and cosmetic industries. For example, water-soluble dyes as illustrated by PD & C Yellow No. 5, water-insoluble dyes and lakes as illustrated by .D & C Green No. 5 and pigments as illustrated by yellow, brown, red and black iron oxides, titanium dioxide and barium sulfate are suitable as colorants.
The method of coating core tablets in accordance with the invention comprises forming the syrup or sugar solution in which is suspended the opacifying material by the use of suitable mixing equipment. The suspension is then added to core tablets in a rotating coating pan and the appropriate number of coats applied with air drying after each coat. At any stage colors of the type described above can be added if desired by adding the appropiate color to the syrup and applying the number of coats necessary to give the desired coloring.
The following examples will further illustrate the invention, without however limiting the latter thereto.
Example 1 Coating suspensions incorporating various dyes were prepared as follows:
(A) Grams FD & C Yellow No. 5 0.20
Titanium dioxide, N.F. 7.20
Sucrose (as 70% syrup) 360.00
PD 8.: C Blue No. 1 0.07
Titanium dioxide, N.F. 7.20
Sucrose (as 70% syrup) 360.00
PD & C Yellow No. 6 0.22
Titanium dioxide, N.F. 7.20
Sucrose (as 70% syrup) 360.00
FD & C Red No. 4 0.25
Titanium dioxide, N.F. 7.20
Sucrose (as 70% syrup) 360.00
Mapico Black 0.72
Titanium dioxide, N.F. 7.20
Sucrose (as 70% syrup)- 360.00
Mapico Black 0.36
Brown iron oxide 7.20
Sucrose (as 70% syrup) 360.00
The dyes and pigments were suspended in the syrup and thoroughly mixed. Each of the coloring compositions was added to sized unrounded placebo tablets in a rotating pan until the tablets were evenly covered. The result- Example 2 Grams Titanium dioxide, NF. 14.0 Sucrose (as 70% syrup) 800.0
The above suspension was applied to a run of sized, unrounded oxypertine tablets rotating in a coating pan. A total of 40 mg. per tablet of the coating composition Was applied in about two and one-half hours to give a white sugar coated tablet equal in quality to oxypertine tablets coated in the conventional in five hours.
Example 3 Kilograms Brown iron oxide 0.232
Vanillin 0.004 Sucrose (as 70% syrup) 9.200
A suspension of the above ingredients was applied to a run of size, unrounded pancreatin-containing digestant tablets sold under the trademark Doxegest rotating in a coating pan. Application of the coating composition required about two and one-half hours and the resultant brown tablet was comparable to subcoated Doxegest tablets and required about one-third the time.
Example 4 Grams Titanium dioxide, NF. 2.80 FD & C Yellow No. 5 .062
Sucrost (as 70% syrup) 250.00
A suspension of the above ingredients was applied to a run of sized, unrounded cold tablets containing phenylephrine sold under the trademark Neosynephrine, acetyl p-aminophenol and vitamin C rotating in a coating pan. A total of 125 mg. per tablet was applied in about two and one-half hours. The yellow tablet thus obtained was equal in quality to sized, unrounded cold tablets coated in the conventional manner in six hours.
I claim:
1. .A method of coating tablets which comprises repeatedly adding portions of an aqueous suspending medium containing a non-toxic pharmaceutically acceptable pigment to sized, unround tablets rotating in a coating pan.
2. The method of claim 1 in which the pigment is selected from the group consisting of titanium dioxide, calicum carbonate, barium sulfate and iron oxide.
3. The method of claim 1 in which the aqueous suspending medium is a syrup solution.
4. The method of claim 1 in which a member of the group consisting of water-soluble and water-insoluble dyes is incorporated in the aqueous suspending medium.
5. The method according to claim 1 in which the aqueous suspending medium comprises a sucrose solution containing titanium dioxide and a colorant, and
.drying the finished tablets.
References Cited by the Examiner UNITED STATES PATENTS 9/62 Ralf 16782 9/64 Jeffries 16782
Claims (1)
1. A METHOD OF COATING TABLETS WHICH COMPRISES REPEATEDLY ADDING PORTIONS OF AN AQUEOUS SUSPENDING MEDIUM CONTAINING A NON-TOXIC PHARMACEUTICALLY ACCEPTABLE PIGMENT TO SIZED, UNROUND TABLETS ROTATING IN A COATING PAN.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US263100A US3185626A (en) | 1963-03-06 | 1963-03-06 | Tablet coating method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US263100A US3185626A (en) | 1963-03-06 | 1963-03-06 | Tablet coating method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3185626A true US3185626A (en) | 1965-05-25 |
Family
ID=23000366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US263100A Expired - Lifetime US3185626A (en) | 1963-03-06 | 1963-03-06 | Tablet coating method |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US3185626A (en) |
Cited By (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3361631A (en) * | 1963-09-30 | 1968-01-02 | Sandoz Ag | Method of sugar coating pharmaceutical tablets |
| US3421920A (en) * | 1965-05-25 | 1969-01-14 | Ciba Geigy Corp | Tablet coating containing a linear poly-1,3-beta-glucoside |
| US4146653A (en) * | 1976-08-11 | 1979-03-27 | J. Pfrimmer & Co. | Process of manufacturing dragees |
| WO1981001100A1 (en) * | 1979-10-17 | 1981-04-30 | Roquette Freres | Process for hard coating with sorbitol and products obtained thereby |
| FR2467597A1 (en) * | 1979-10-17 | 1981-04-30 | Roquette Freres | HARD DRAGEIFICATION PROCESS WITH SORBITOL AND PRODUCTS THUS OBTAINED |
| US4421738A (en) * | 1979-07-31 | 1983-12-20 | Eisai Co., Ltd. | Sugar-coated tablet containing fat-soluble pharmaceutical material |
| US4693750A (en) * | 1985-02-22 | 1987-09-15 | Meggle Milchindustrie Gmbh & Co. Kg. | Direct tabletting agent |
| US4820524A (en) * | 1987-02-20 | 1989-04-11 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
| US4867983A (en) * | 1987-02-20 | 1989-09-19 | Mcneilab, Inc. | Method for double dipping gelating coated caplets |
| US4965089A (en) * | 1989-04-10 | 1990-10-23 | Sauter Manufacturing Corp. | Method and apparatus for the gelatin coating of caplets |
| US4966771A (en) * | 1987-02-20 | 1990-10-30 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
| US4990358A (en) * | 1987-02-20 | 1991-02-05 | Mcneilab, Inc. | Method for double dipping gelatin coated caplets |
| US5198227A (en) * | 1990-01-22 | 1993-03-30 | Mcneil-Ppc, Inc. | Dual subcoated simulated capsule medicament |
| US5512314A (en) * | 1993-02-24 | 1996-04-30 | Warner-Jenkinson Company | Dye compositions and methods for film coating tablets and the like |
| US5658589A (en) * | 1989-04-28 | 1997-08-19 | Mcneil-Ppc, Inc. | Subcoated simulated capsule-like medicament |
| US6080426A (en) * | 1994-12-16 | 2000-06-27 | Warner-Lamberg Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
| US6113945A (en) * | 1996-02-26 | 2000-09-05 | L. Perrigo Company | Multi-colored medicament |
| US6245350B1 (en) | 1994-12-16 | 2001-06-12 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
| WO2001037816A3 (en) * | 1999-11-23 | 2001-11-29 | Biochemie Gmbh | Coating of tablet cores |
| US20030108607A1 (en) * | 2001-09-28 | 2003-06-12 | Szymczak Christopher E. | Film forming compositions containing sucralose |
| US20030219484A1 (en) * | 2001-09-28 | 2003-11-27 | Sowden Harry S. | Immediate release dosage form comprising shell having openings therein |
| US20040022755A1 (en) * | 2002-08-02 | 2004-02-05 | Satish Kamath | Polyacrylic film forming compositions |
| WO2004028508A1 (en) | 2002-09-28 | 2004-04-08 | Mcneil-Ppc, Inc. | Modified release dosage forms with two cores and an opening |
| US20050008696A1 (en) * | 2001-09-28 | 2005-01-13 | Sowden Harry S. | Systems, methods and apparatuses for manufacturing dosage forms |
| US20050152970A1 (en) * | 2004-01-13 | 2005-07-14 | Rinker Roger A. | Rapidly disintegrating gelatinous coated tablets |
| EP1602363A1 (en) | 2004-06-04 | 2005-12-07 | McNeil-PPC, Inc. | Immediate release dosage form comprising shell having openings therein |
| US20060062811A1 (en) * | 2004-09-21 | 2006-03-23 | Szymczak Christopher E | Medicinal cooling emulsions |
| US20060121145A1 (en) * | 2004-12-07 | 2006-06-08 | Sowden Harry S | System and process for providing at least one opening in dosage forms |
| US20060118991A1 (en) * | 2004-12-07 | 2006-06-08 | Sowden Harry S | System and process for providing at least one opening in dosage forms |
| US20060233882A1 (en) * | 2005-04-15 | 2006-10-19 | Sowden Harry S | Osmotic dosage form |
| US20060233881A1 (en) * | 2005-04-15 | 2006-10-19 | Sowden Harry S | Modified release dosage form |
| US20070128268A1 (en) * | 2005-12-07 | 2007-06-07 | Herwig Jennewein | Pharmaceutical compositions comprising an antibiotic |
| US20070231389A1 (en) * | 2006-03-28 | 2007-10-04 | Bunick Frank J | Non-homogenous dosage form coatings |
| US20070259098A1 (en) * | 2001-05-15 | 2007-11-08 | Cynthia Gulian | Method for dip coating dosage forms |
| US20080031927A1 (en) * | 2006-07-11 | 2008-02-07 | Catani Steven J | Solid oral dosage vitamin and mineral compositions |
| US20080069880A1 (en) * | 2002-05-15 | 2008-03-20 | Bunick Frank J | Enrobed core |
| US20080075766A1 (en) * | 2006-09-25 | 2008-03-27 | Shun-Por Li | Multi-core dosage form having transparent outer coating |
| US20080118571A1 (en) * | 2006-11-21 | 2008-05-22 | Der-Yang Lee | Modified release analgesic suspensions |
| US20080311201A1 (en) * | 2007-06-12 | 2008-12-18 | Lee Der-Yang | Modified release solid or semi-solid dosage forms |
| US20080317677A1 (en) * | 2007-06-22 | 2008-12-25 | Szymczak Christopher E | Laser Marked Dosage Forms |
| US20080317678A1 (en) * | 2007-06-22 | 2008-12-25 | Szymczak Christopher E | Laser Marked Dosage Forms |
| US20090074866A1 (en) * | 2007-09-17 | 2009-03-19 | Jen-Chi Chen | Dip coated compositions containing copolymer of polyvinyl alcohol and polyethylene glycol and a gum |
| US20090092739A1 (en) * | 2001-05-15 | 2009-04-09 | Cynthia Gulian | Method of dip-coating dosage forms |
| US20090162435A1 (en) * | 2007-12-21 | 2009-06-25 | Bunick Frank J | Manufacture of tablet |
| US20090208574A1 (en) * | 2008-02-19 | 2009-08-20 | Jen-Chi Chen | Dip coated compositions containing a starch having a high amylose content |
| US20090324716A1 (en) * | 2008-06-26 | 2009-12-31 | Robert Shen | Coated Particles Containing Pharmaceutically Active Agents |
| US20100062061A1 (en) * | 2008-09-05 | 2010-03-11 | Kenneth Day | Method For Making Cetirizine Tablets |
| US7838026B2 (en) | 2001-09-28 | 2010-11-23 | Mcneil-Ppc, Inc. | Burst-release polymer composition and dosage forms comprising the same |
| US8067029B2 (en) | 2004-01-13 | 2011-11-29 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
| EP2385766B1 (en) | 2009-01-07 | 2018-04-18 | Chr. Hansen Natural Colors A/S | A composition comprising calcium carbonate as a white pigment |
| US20220008344A1 (en) * | 2018-12-17 | 2022-01-13 | Roquette Freres | Sugar-coated solid forms having improved stability |
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| US3149038A (en) * | 1961-09-05 | 1964-09-15 | Dow Chemical Co | Thin film coating for tablets and the like and method of coating |
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| US3054724A (en) * | 1960-05-12 | 1962-09-18 | Smith Kline French Lab | Coloring discrete solids and compositions therefor |
| US3149038A (en) * | 1961-09-05 | 1964-09-15 | Dow Chemical Co | Thin film coating for tablets and the like and method of coating |
Cited By (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3361631A (en) * | 1963-09-30 | 1968-01-02 | Sandoz Ag | Method of sugar coating pharmaceutical tablets |
| US3421920A (en) * | 1965-05-25 | 1969-01-14 | Ciba Geigy Corp | Tablet coating containing a linear poly-1,3-beta-glucoside |
| US4146653A (en) * | 1976-08-11 | 1979-03-27 | J. Pfrimmer & Co. | Process of manufacturing dragees |
| US4421738A (en) * | 1979-07-31 | 1983-12-20 | Eisai Co., Ltd. | Sugar-coated tablet containing fat-soluble pharmaceutical material |
| US4423086A (en) * | 1979-10-17 | 1983-12-27 | Roquette Freres | Process for hard coating with sorbitol and products obtained thereby |
| FR2467597A1 (en) * | 1979-10-17 | 1981-04-30 | Roquette Freres | HARD DRAGEIFICATION PROCESS WITH SORBITOL AND PRODUCTS THUS OBTAINED |
| WO1981001100A1 (en) * | 1979-10-17 | 1981-04-30 | Roquette Freres | Process for hard coating with sorbitol and products obtained thereby |
| US4693750A (en) * | 1985-02-22 | 1987-09-15 | Meggle Milchindustrie Gmbh & Co. Kg. | Direct tabletting agent |
| US4820524A (en) * | 1987-02-20 | 1989-04-11 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
| US4867983A (en) * | 1987-02-20 | 1989-09-19 | Mcneilab, Inc. | Method for double dipping gelating coated caplets |
| US5314537A (en) * | 1987-02-20 | 1994-05-24 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
| US4966771A (en) * | 1987-02-20 | 1990-10-30 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
| US4990358A (en) * | 1987-02-20 | 1991-02-05 | Mcneilab, Inc. | Method for double dipping gelatin coated caplets |
| AU620829B2 (en) * | 1987-12-04 | 1992-02-27 | Mcneil Consumer Products Company | Method for double dipping gelatin coated caplets |
| US4965089A (en) * | 1989-04-10 | 1990-10-23 | Sauter Manufacturing Corp. | Method and apparatus for the gelatin coating of caplets |
| US7087242B2 (en) | 1989-04-28 | 2006-08-08 | Mcneil-Ppc, Inc. | Subcoated simulated capsule-like medicament |
| US6120801A (en) * | 1989-04-28 | 2000-09-19 | Mcneil-Ppc, Inc. | Subcoated simulated capsule-like medicament |
| US20020031546A1 (en) * | 1989-04-28 | 2002-03-14 | Parekh Kishor B. | Subcoated simulated capsule-like medicament |
| US5658589A (en) * | 1989-04-28 | 1997-08-19 | Mcneil-Ppc, Inc. | Subcoated simulated capsule-like medicament |
| US5770225A (en) * | 1989-04-28 | 1998-06-23 | Mcneil-Ppc, Inc. | Process of preparing a subcoated simulated capsule-like medicament |
| US5916592A (en) * | 1989-04-28 | 1999-06-29 | Mcneil-Ppc, Inc. | Subcoated simulated capsule-like medicament |
| US6326026B1 (en) | 1989-04-28 | 2001-12-04 | Mcneil-Ppc, Inc. | Subcoated simulated capsule-like medicament |
| US6214380B1 (en) | 1989-04-28 | 2001-04-10 | Mcneil-Ppc, Inc. | Subcoated simulated capsule-like medicament |
| US5198227A (en) * | 1990-01-22 | 1993-03-30 | Mcneil-Ppc, Inc. | Dual subcoated simulated capsule medicament |
| US5296233A (en) * | 1990-01-22 | 1994-03-22 | Mcneil-Ppc, Inc. | Dual subcoated simulated capsule-like medicament |
| US5512314A (en) * | 1993-02-24 | 1996-04-30 | Warner-Jenkinson Company | Dye compositions and methods for film coating tablets and the like |
| US6245350B1 (en) | 1994-12-16 | 2001-06-12 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
| US6080426A (en) * | 1994-12-16 | 2000-06-27 | Warner-Lamberg Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
| US6113945A (en) * | 1996-02-26 | 2000-09-05 | L. Perrigo Company | Multi-colored medicament |
| US8652517B2 (en) * | 1999-11-23 | 2014-02-18 | Sandoz Gmbh | Coating of tablet cores |
| WO2001037816A3 (en) * | 1999-11-23 | 2001-11-29 | Biochemie Gmbh | Coating of tablet cores |
| US20060034917A1 (en) * | 1999-11-23 | 2006-02-16 | Reinhard Entner | Coating of tablet cores |
| US7785650B2 (en) | 2001-05-15 | 2010-08-31 | Mcneil-Ppc, Inc. | Method for dip coating dosage forms |
| US20070259098A1 (en) * | 2001-05-15 | 2007-11-08 | Cynthia Gulian | Method for dip coating dosage forms |
| US20090092739A1 (en) * | 2001-05-15 | 2009-04-09 | Cynthia Gulian | Method of dip-coating dosage forms |
| US20030235616A1 (en) * | 2001-09-28 | 2003-12-25 | Sowden Harry S. | Modified release dosage form |
| US7972624B2 (en) | 2001-09-28 | 2011-07-05 | Shun-Por Li | Method of manufacturing modified release dosage forms |
| US20050019407A1 (en) * | 2001-09-28 | 2005-01-27 | Sowden Harry S. | Composite dosage forms |
| US8673190B2 (en) | 2001-09-28 | 2014-03-18 | Mcneil-Ppc, Inc. | Method for manufacturing dosage forms |
| US20050266084A1 (en) * | 2001-09-28 | 2005-12-01 | Shun-Por Li | Modified release dosage forms |
| US20040213849A1 (en) * | 2001-09-28 | 2004-10-28 | Sowden Harry S. | Modified release dosage forms |
| US20050008696A1 (en) * | 2001-09-28 | 2005-01-13 | Sowden Harry S. | Systems, methods and apparatuses for manufacturing dosage forms |
| US8545887B2 (en) | 2001-09-28 | 2013-10-01 | Mcneil-Ppc, Inc. | Modified release dosage forms |
| US8309118B2 (en) | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
| US8114328B2 (en) | 2001-09-28 | 2012-02-14 | Mcneil-Ppc, Inc. | Method of coating a dosage form comprising a first medicant |
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| US7955652B2 (en) | 2002-05-15 | 2011-06-07 | Mcneil-Ppc, Inc. | Enrobed core |
| US7429619B2 (en) | 2002-08-02 | 2008-09-30 | Mcneil Consumer Healthcare | Polyacrylic film forming compositions |
| US20040022755A1 (en) * | 2002-08-02 | 2004-02-05 | Satish Kamath | Polyacrylic film forming compositions |
| WO2004028508A1 (en) | 2002-09-28 | 2004-04-08 | Mcneil-Ppc, Inc. | Modified release dosage forms with two cores and an opening |
| EP2255795A1 (en) | 2002-09-28 | 2010-12-01 | McNeil-PPC, Inc. | Immediate release dosage form comprising shell having openings therein |
| US7879354B2 (en) | 2004-01-13 | 2011-02-01 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
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| US20110086098A1 (en) * | 2004-01-13 | 2011-04-14 | Rinker Roger A | Rapidly disintegrating gelatinous coated tablets |
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| US10092521B2 (en) | 2004-01-13 | 2018-10-09 | Johnson & Johnson Consumer Inc. | Rapidly disintegrating gelatinous coated tablets |
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| US20060062811A1 (en) * | 2004-09-21 | 2006-03-23 | Szymczak Christopher E | Medicinal cooling emulsions |
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| US20060118991A1 (en) * | 2004-12-07 | 2006-06-08 | Sowden Harry S | System and process for providing at least one opening in dosage forms |
| US20090148523A1 (en) * | 2004-12-07 | 2009-06-11 | Sowden Harry S | System and process for providing at least one opening in dosage forms |
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| US20060233881A1 (en) * | 2005-04-15 | 2006-10-19 | Sowden Harry S | Modified release dosage form |
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| US20060233882A1 (en) * | 2005-04-15 | 2006-10-19 | Sowden Harry S | Osmotic dosage form |
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| US20080031927A1 (en) * | 2006-07-11 | 2008-02-07 | Catani Steven J | Solid oral dosage vitamin and mineral compositions |
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| US8771716B2 (en) | 2006-11-21 | 2014-07-08 | Mcneil-Ppc, Inc. | Modified release analgesic suspensions |
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| US20080311201A1 (en) * | 2007-06-12 | 2008-12-18 | Lee Der-Yang | Modified release solid or semi-solid dosage forms |
| US20110200537A1 (en) * | 2007-06-22 | 2011-08-18 | Szymczak Christopher E | Laser marked dosage forms |
| US20080317677A1 (en) * | 2007-06-22 | 2008-12-25 | Szymczak Christopher E | Laser Marked Dosage Forms |
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| US20090074866A1 (en) * | 2007-09-17 | 2009-03-19 | Jen-Chi Chen | Dip coated compositions containing copolymer of polyvinyl alcohol and polyethylene glycol and a gum |
| US20090162435A1 (en) * | 2007-12-21 | 2009-06-25 | Bunick Frank J | Manufacture of tablet |
| US8357395B2 (en) | 2007-12-21 | 2013-01-22 | Mcneil-Ppc, Inc. | Manufacture of tablet |
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| US20090208574A1 (en) * | 2008-02-19 | 2009-08-20 | Jen-Chi Chen | Dip coated compositions containing a starch having a high amylose content |
| US20090324716A1 (en) * | 2008-06-26 | 2009-12-31 | Robert Shen | Coated Particles Containing Pharmaceutically Active Agents |
| US8282957B2 (en) | 2008-06-26 | 2012-10-09 | Mcneil-Ppc, Inc. | Coated particles containing pharmaceutically active agents |
| US20100062061A1 (en) * | 2008-09-05 | 2010-03-11 | Kenneth Day | Method For Making Cetirizine Tablets |
| US8383632B2 (en) | 2008-09-05 | 2013-02-26 | Mcneil-Ppc, Inc. | Method for making cetirizine tablets |
| EP2385766B1 (en) | 2009-01-07 | 2018-04-18 | Chr. Hansen Natural Colors A/S | A composition comprising calcium carbonate as a white pigment |
| US20220008344A1 (en) * | 2018-12-17 | 2022-01-13 | Roquette Freres | Sugar-coated solid forms having improved stability |
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