US3161195A - Two-compartment aspirating hypodermic syringe - Google Patents

Description

Dec. 15, 1 A. s. TAYLOR ETAL 3,161,195

TWO-COMPARTMENT ASPIRATING HYPODERMIC SYRINGE Filed Jan. 29, 1963 2 Sheets-She t l 4 13 g. 1 4- =a N INVENTORS. ARTHUR S. TAYLOR ELLSWORTH R. SANDHAGE ATTORNEY Dec. 15, 1964 5 TAYLOR ETAL 3,161,195

TWO-COMPARTMENT ASPIRATING HYPODERMIC SYRINGE 2 SheetsSheet 2 Filed Jan. 29, 1965 INVENTORS. ARTHUR S TAYLOR ELLSWORTH R. SANDHAGE Aka ATTORNEY United States Patent 3,161,135 TWG-QGMPARTMENT ASPKRATENG HYPQBERMI dir'RihlGE Arthur Sinclair :Iaylor, Spring Valley, and Ellsworth Roland antihage, Pearl River, N.Y., assignors to American Cyanamid @ompauy, Stamford, Chum, a

corporation of Maine Filed tau. 29, W63, Eer. No. 253366 7 tllainis. (6i. i28--2-2ii) This invention relates to a two-compartment hypodermic syringe package providing for the storage of a solid component and a liquid component of an injectable product under sterile conditions with the solid component ahead of a piston and the liquid behind the piston and a one-way valve through the piston so that the liquid is transferred to and mixed with the solid in preparation for injection, and which piston is attached to the plunger so that on injection the location of the needle may be checked by aspiration; and which in a preferred embodiment provides for the hypodermic needle to be stored in the plunger.

The piston on the plunger incorporates a unique type of sleeve valve in which a resilient sleeve overlies a part of the plunger having at least one passage for the liquid so that the liquid flows through the passage, and expands the flexible sleeve for permitting the liquid to flow one way only, and which by its natural resilience closes against the plunger so as to give a positive one-way action with no leakage up to pressures sufficient to mechanically rupture the components.

In pharmaceutical practice, there are many products Whose injection hypodermically is desired but which products must be dry for reasonable shelf life and must, therefore, be mixed with a liquid diluent just prior to injection. The diluent itself may contain pharmacologically effective constituents, or solubilizing constituents.

The art has long been familiar with various efforts to provide a hypodermic syringe in which a solid component could be stored with a separate compartment for a liquid diluent so that the two could be mixed just prior to injec* tion. Among such is United States Patent 1,154,677, 3. H. Wedig, Hypodermic Syringe, September 28, 1915, in which a solid medi ament is stored ahead of a plunger in a hypodermic syringe barrel, complete with hypodermic needle, which plunger serves as a container for a liquid so that the plunger may be withdrawn and the liquid poured into the barrel, the liquid and the solid thus mixed, and used for injection. A variant on this appears in United States Patent 1,702,654, E. D. Kellogg, Reptile-Venom-Antidote Container, February 19, 1929, in which the entire package is in compact cartridge configuration for long storage. To avoid the exposure of the solid and/ or the liquid to air, and compromise of sterility during reconstitution, various devices have been developed in which the liquid and solid components could be mixed by variferred to and mixed with the solid components, which mixture is then withdrawn from the second chamber for administration. Such a device in which the container can t be likened to two glass vials with a common bottom serving as compartments is shown in Canadian Patent 559,-

864, J. C. Bird and Henry C. Wendt, In, Bottle, De-

cember 31, 1957. Such a common container insures that the proper pair of components are stored and used together.

t is desirable that a package and hypodermic syringe combination be producible at such a low cost as to be disposable and that powder or other solid be completely separate from the liquid so that even moisture-sensitive powder medicaments can be stored at full potency for a prolonged period, and that the product be readily mixed for administration with a minimum of chance for error in manipulation, or compromise of sterility; and that the package preferably have available with it a hypodermic needle and; additionally, that the package be economical to manufacture and of such design that the product can be economically assembled in sterile form with a minimum chance of manufacturing error or compromise of sterility. A minimum dead space, or volume of liquid which cannot be injected is desirable.

The invention, comprising the features of construction and combination of elements and arrangement of parts to achieve these objectives and others which will be obvious from an inspection of the construction hereinafter set forth, is set forth in the description below, which applies to a specific embodiment. It is to be understood that certain of the features of construction of the preferred embodiment, together with their advantages, may be omitted while coming within the scope of the present invention, which is defined in the appended claims.

A fuller understanding of the nature and objects of the invention is had by studying the following detailed description and the accompanying drawings, in which:

FIGURE 1 is a pictorial partially sectional view of the combination package and syringe, including a needle stored in the plunger;

FIGURE 2 is a modification showing a solid plunger without provision for a needle in section, as a pictorial; and

FIGURE 3 is a diagrammatically exploded view showing the various components of the syringe and package of FIGURE 1 with the components appearing separately for clarity.

In the embodiment shown in FIGURE 1, a generally cylindrical barrel it is formed of glass or plastic with a barrel flange 12 at the rear end and a transverse wall 13 at the forward end. When made of glass by manufacturing processes which are adapted thereto, the barrel may be a true cylinder. For many purposes it is more convenient that the barrel have a slight conical taper, as it is easier to withdraw the internal mold if there is a slight taper, and resiliency of the piston 14 permits its use in a barrel with a slight taper. The term forward end refers to the end at which the hypodermic needle is to be attached when used for injection and the rear end is used to refer to the end of the barrel which is manipulated by the operator and is opposed to the forward end. At the forward end is a needle holding tip 15. Conveniently this tip is integral with the forward wall and barrel but in accordance with conventional practice the tip may be of metal and separately attached. The tip has such taper as to fit in a conventional hypodermic needle. Where a metal tip is used, the standard Luer-lock type of fitting may be used in order that the needle may be locked on the tip. Such tips are conventional in the industry. Through the tip is a tip bore 16 for the discharge of the contents of the hypodermic syringe. On the tip is a tip shield 17, preferably of a resilient material such as natural or synthetic rubber or a resilient plastic, and molded to the tip shield is a bore pin 18, which passes into the tip bore to prevent the contents of the hypodermic syringe from flowing into and blocking the tip bore and to insure that the lumen of-the tip here is kept open. This bore pin is conveniently of metal and firmly retained in the tip shield so that when sothat during-storage there is no. moisture l'eakage throughtheiyalvegaBecause 1' f against the utside of the boss th va effective o 3 the tip shield is removed the bore pin is also withdrawn. The tip shield keeps, the end and outside of the needleholding tip sterile and serves to protect the front end of thehypoderrnic syringe from shock'if dropped because of its resiliency. r

Inside of the barrel is a resilientpiston the piston is located near the center of the barrel during storage although it may be located at such a point that it divides the barrel into a forward compartment 19 and a rear compartment 20, each having such volume as is desired for a particular pharmaceutical product. For some products the forward compartment for the solid component is markedly smaller than the rear compartment for the liquid component, but the choice ofsize is such as to conveniently hold the selected components." On the outside of the piston for contactwith thebarrel is at least one annular ring 21. In the modification shown 14; usuall to force the resilient sleeve into the liquid conduit which is thus completely obstructed and'the'valve will be comfpletely leakproof against reverse pressures normally associately withlhypoderrnic syringes; and, in fact, does not leak untilthe pressures are sufiicient to cause mechanical failure of some of the components. Conveniently, the

' plunger is a plastic molding, and the plastic itself would three annular rings are used to give gre'aterprotection again-st moisture leaking past the piston and greater directional control to prevent the piston from becoming cocked in the barrel. The useof a plurality ofa'nnular rings,

such as three rings, each of which is comparatively narrow, reduces the area in contact between the piston an d the barrel, thus reducing friction and the resiliency of the rings gives greater tolerancetowardswariations in the'diameter of the barrel. Thus the barrels can be H manufactured extremely economically and rapidly because the manufacturing tolerances are comparatively large. Inside of the piston and preferably axially is a passage 22 extending! through the piston. Preferably this passage is circular and base groove 23 extending into the piston. Towards the front of the passage is a resilient: valve-sleeve 24 preferably circular in cross S667. tion and surrounding which is a reliefspace 25. The resilient valvefsleeve, may extend completely-forward of the main body of the piston. It is prefered that the sleevebe inset, intothe piston so that there is a minimum ofd'ead, space when the syringe isiused.

vThe piston is attached to the forward end of a plunger 26. The forward end of the plunger isformed with n r r r largementZS... When the piston is inserted into the barrel,

the, barrel prevents the piston from expanding and thus I 49- boss 27 which extends into the passage in the piston and hasja cooperating enlargement 28 which fits -into the retaining" groove in the plunger and holds the piston firmly in position on the boss. dust behind the boss is a v shoulder 29. against which the pistonfits and which acts 1 to keep the piston frornsliding backwards on theplhnger...

fail in'compression before the valve'would leak. At the rear end of the plunger is a thumb piece 33 against which the thumb of the operator presses duringoperation of the syringe. I

A plunger sealing stopper34 surrounds the plunger and fills the space between the plunger and the inside of the barrel to. form the back end of the rear compartment.

Preferably the barrel isvvformed'with a barrelfinger flange ll. As shown in FIGURE 1, the finger flange has fiat areas 36 so that the syringe will not roll when laid down on a flat surface. The stopper 34 is held in posi- ,tion by a stopper retainer 37 which may conveniently be a metal clip fitting over the stopper and fitting under the finger flanges or may be an aluminum seal of the type usually vused to close rubber stoppered pharmaceutical bottles-t The stopper 34 may be formed from an ordinary pharmaceutical stopper by cutting a hole therein large enough for theplunger. v

.During assembly'the. stopper retainer 37 is slid over the front end of the plunger, the stopper is slid over the 1 lunger and then the'pisto'n 'is expanded and slid over the end of the boss onftheplun'gerand contracts down around the boss so that' the groove 23.,encloses the enfirmly locksv the. piston on the forward end of the plunger. At the rear. of the plunger passing through thethumb p ece 33 is a needle cavity 38.- A' vent port 39 communicates between the .needle cavity and the outside of the plunger and is so located th at'it isv closed by the stopper-during shipment-and storage. I a 1 Inside of thelneedle cavity is a needle sheath 49. The Y needle'sheath is-retainedginthe needle cavity 38 in the plunger 26 by friction or threads or other means to prevent it from falling out; If the sheath is of polyethylene it may be molded of such size thatitis fractionally re- The shoulder may-be of greater diameter than the main f body of they plungergdepending upon the capacity desired for the. compartments. As shown in :FIGURE 1, the

enlargement on the boss has 'a' forward conical. configura-ftion 30 and a'flat rear configuration 31 so that the piston ,tained. in the needlecavity without additional cost, which is the preferred construction.v Insideot theneedle sheath is'a-hypodermic needle llcomprisinga cannula 42 anda hub 43. The 'hubaand cannula are of conventional configuration. Preferably the hub. has hub'lugs 44 which canfslide over and be expanded by the conical configura' tiohdurihg assembly but is prevented from'slidingpff of the boss .by the flat rear configuration of the enlargementi The forwardiend of the boss is slightlylarger thanand slightly expands the valve sleeve which is an integral part of the pistons Thus the resilience ofthe-"vvalve sleeve causes the valvesleeve to shrink slightly against the for-f In use, under pressure;- liqn id passes through the liquid conduitand-slightly expandsthe valve sleeve and, hence, ;canreadily flowrbetween the plunger boss and;the-. valve} -'-"slee've and into the forward compartment. Becausei the valve sleeyeis slightly ,expanded by;-the boss/the owof-n liquid isprev'entedin thehbs'nce of operating p ssu'res ward, end of the boss. Aliquid conduit 32' extends from} "thetpo'rtion of the plunger behind the piston,-an'd i'sj'in' communication the1'ewith,;totheportionof the boss'wh'ich' is inside of'thevalve sleeve flh'e configuration shown a [in FIGURE. 1, is agslot integrally molded in. the bo'ssat thetimethe .plun'ger' is manufactured. Erilledfhol'es; I or tether shapesmay bqused. J

out of its own weight and the friction may beused to the tip; In-FIGURE 3, thejfiutes areshown in av-rotate'd Y. fse ct ion, v i

Outside of the'sheath andfittingthereover is v a sheath cap 14 Thisfis'conveniently niblded to a f "fit-Carnelian act the heath soj tha't it is'hldflin a aeaieisaaatea amp t fare sealed oit and sterility isfretained 7' to the inside of the; sheat tioned.

means are to be used the sterilizing gas passages may be omitted.

M elhod of Use In use a solid component, as for example a powdered mixture of tetracycline with suitable adjuvants is placed in the forward compartment and Water is placed in the rear compartment. The two components are separated from each other and the combination functions as a twocompartment package. The shelf life is not known, but is at least some several years, and may be a great many years. At the time when reconstitution is desired, the plunger is pulled back, thus decreasing the annular space between the barrel and the plunger, causing the liquid in the rear compartment to flow through the liquid conduit into the thus enlarged forward compartment. The powder quickly dissolves and is ready for injection. The tip shield is removed. The hypodermic needle in the needle sheath is removed from the rear of the plunger, the needle sheath cap removed and the hypodermic needle placed on .the needle holding tip. The plunger is advanced, conveniently by pressing against the thumb piece while holding the barrel between the fingers and against the finger flange, with the needle pointing upwardly to permit the escape of gas present in the forward compartment. As the thumb piece advances the vent port 39 breaks the vacuum in the rear compartment permitting the needle and piston to slide forward more readily and free from the eifects of vacuum in the rear compartment. After all trapped gas has escaped, the solution is ready for injection with the device being then used as a conventional hypodermic syringe. Because the valve sleeve presses against the boss and forms a very eifective one-way valve, but requires considerable pressure to operate, the plunger may be pulled back slightly after insertion of the needle in the subject to check on the location of the insertion of the needle. If a vein or artery has been penetrated, blood is readily aspirated Whereas if the needle is in tissue the usual resistance to aspiration for such a location exists. The present hypodermic syringe may be used for intramuscular, intravenous, or other hypodermic placement depending upon the medical requirements of the patient and the product. The user can be certain that its location is as desired, whatever that location may be.

Manufacture During manufacture the formation of the components is by conventional and obvious means. The assembly may be accomplished by separately sterilizing the components and assembling under sterile conditions or the device may be assembled complete and sterilized by radiation as, for example, a beam of high voltage electrons, or X-rays, or radiation. Monoenergetic radiation from a cobalt or cesium source gives excellent results. When the method of assembly is to assemble the hypodermic needle, its sheath and sheath cap with the plunger the stopper retainer and the piston, the assembly may be sterilized by heat; then the tip shield is placed on the barrel and sterilized by heat; and then under aseptic conditions a heat-sensitive solid is inserted into the barrel, the piston inserted, the desired quantity of liquid added, and the stopper assembly and the stopper retainer posi- A variant on this is to insert the needle sheath containingthe needle separately as a final step which permits the use of a needle sheath and hypodermic needle.

which have been sterilized by ethylene'oxide and are of plastics which would melt under steam sterilizing con ditions. The stopper and piston are coated with silicone Oil to,

reduce friction in assembly, if desired. Coating the piston with silicone oil reduces the permeability of the stopper to moisture and prolongs the shelf life of m 'isgeneral configuration but has a solid plunger 49 in which is a vent slot 5% for breaking the vacuum in the rear compartment after the components have been mixed. In this modification an aluminum seal 51 is used to hold the stopper in position.

Other variants on this invention are obvious to those sxillcd in the art as, for example, the valve may be used in other types of construction. Other methods may be used for assembly, and the materials of construction may vary depending upon economic factors and the possible interactions by the medicament and component parts of the package. Such variations are Within the scope of the present invention, which-are defined by the following claims. I

We claim:

1. A combination aspirating hypodermic syringe and two-compartment package comprising:

a generally cylindrical barrel, having at the rear end a barrel flange, and at the forward end a transverse wall, a needle holding tip extending outwardly from said wall, said Wall and tip having therethrough a tip bore;

a tip shield on said tip, a bore pin extending from said tip shield substantially through said bore, and removable with the tip shield, to protect the sterility of the tip;

a resilient piston in said barrel and located toward the center of said barrel, dividing the barrel into a forward compartment, for a solid component, a solid medicament component therein, and a rear compartment, for a liquid component, a liquid component therein, and on said piston, at least one annular ring in sealing engagement with said barrel, said piston having therein an axial passage and a plunger retaining groove in said passage, and coaxial with said passage, and at the forward end thereof a resilient valve sleeve, concentrically spaced from the main portion of the piston;

a plunger extending from the rear into said barrel, the forward end of the plunger having thereon a boss extending into the axial passage in said piston, and having on said boss a cooperating enlargement entering into and cooperating with the groove in the passage in said piston, thereby firmly retaining the piston on said plunger, the plunger boss having such size as to extend into and at least slightly expand the valve sleeve on the piston, and in said plunger a liquid conduit extending from the portion of the plunger behind the piston in the rear compartment to the boss portion of the plunger inside of the resilient valve sleeve, and on the rear of the plunger and exterior of the barrel :1 thumb piece;

a plunger sealing stopper cooperating with the rear of the barrel and the plunger to form a liquid-tight seal therebetween; a stopper retainer, to hold said sealing stopper in position; and said plunger also having therein a vacuum breaking vent to introduce air into the rear compartment as the plunger moves forward of its storage position;

and said plunger also having therein a needle cavity, and in said cavity a needle sheath, means to retain the needle s math in the needle cavity, a hypodermic needle comprising cannula and hub portions in said sheath, cooperating rotation preventing lugs on the exterior of said hub portion and interiorly of the needle sheath, to hold the hubagainst rotation while being applied to the needle holding tip; and a needle sheath cap fitting overand in engagement with said sheath to protect the hypodermic needle'against contamination during storage; i

said combination" cooperating to maintain the contents merit tothe forward compartment or rearward move ment of the plunger, causing mixture of the solid.

i 4 attachment ,of thei dricalibarrfel, having atthe rear-en and liquid components, discharge of i gas by forward movement of the plunger and piston, permit att'aclr ment of the needle, aspiration as desired to confirm protect the sterility of the tip; a resilient piston in said a desired location of the hypodermic needleon insertion, and hypodermic injection of the package contents, all operations being sterilely performed."

2. A combination aspirating hypodermic syringe and two-compartmentpackage comprising: i

a generally cylindrical barrel, having at barrel flange, and at the forward end a transverse wall, a needle holding tip extending outwardly from said wall, said wall and tip having therethrough a a tip shield on said tip, a bore pin-extending from said tip shield substantially through said'bore, and remov- I able with the tipshield, to protect the sterility of the 1 a resilient piston in said barrel and "located towards the center of said barrel, dividing the barrel into a forward compartment, for a solid component, and a rear compartment for for a liquid component, and on said piston at least one annular ring in sealing engagement 'with said barrel, said pistonhaving therein an axial passage and a plunger retaining groove in said passage, and coaxial with said passage, and attire forward end thereof a resilient valve'sleeve, concentrically-spaced from the main portion of the piston;

a plunger extending from the rear into said barrel, the

forward endv of the plunger having thereon a boss extending into the axial passage in said piston, and having on said boss a cooperating enlargement entering into and cooperatin with'the groove 1n the passage in said piston, thereby firmlyretaining the I piston on said plunger, the plunger boss having such size as to extend into and at least, slightly expand the valve sleeve on the piston, and'in said plunger a liquid conduit extending frornithe portion of the plunger behind the piston in therear compartment to the boss portion of the plunger inside of the resilient valve sleeve, and on the rear of the plunger and exterior of the barrel a thumb piece;

it ing therethrough'a tip bore; ar-tip shield on said tip, a

bore pin extending .from said tip shield substantially through said bore, and removable with the tip shield, to

barrel and located towards "the center of said barrel, dividingthe barrel into a forward compartment, for a solid component, and a rear compartment, for a liquid compo;

nent, and on said piston, at least one annular ring in seal- .ing engagement with said barrel, said piston having therefrom the main portion of thepiston; a plunger extending from the rear into said barrel, the forward end of the plunger having thereon a boss extending into the axial passage insaid pi'ston, and having on said boss a cooperating enlargement entering into and cooperating with the groove in the passage in said piston, thereby firmly retaining the piston on said plunger, the plunger boss having such size as to extend into and at least slightly expand thevalve sleeve on the piston, and in said plunger a liquid conduit extending from the portion of the plunger behind the piston in the rear compartment to the boss portion of the plunger inside of the resilient valve sleeve, andjon the rear of "the'plunge'r and exterior-of the barrel, a thumb piece; a plunger sealing stoppercooprating with the rear of the'barrel and theplunger to-forrn a liquid-tight seal therebetween; a stopper retainer, to hold said sealing stopper in positionpsaid plunger 'alsohaving therein a vacuum brealdng'ventato introduce air into "of its storage position. p 4. A' combination aspirating hypodermic syringe and two-compartment packagecomprising: agenerally cylin- I drical barrel, having at the rear end a barrel. flange, and

at the forward end'a-transverse wall, aneedle holdingtip extending outwardly from said wall, ,said Wall and tip having' therethrough a tip bore; means to protect the 1 sterility of the tip during'storage; a resilientpistonin said a'plunger sealing stopper cooperating with the rear of V the barrel and theplunger to form a liquid-tight seal therebetween; a stopper retainer, to hold said sealing stopper in position; and said plunger also having therein a vacuum breaking vent to introduce air into the rear compartment: as the plunger movesforward of its storage position, V a and said plunger also having therein a needle cavity, and in said' cavity aneedle sheath, means to retainthe needle sheath in the needle cavity, a hypodermic barrel and located towards thec'e'nter'of said, barrel, di- 7 viding the barrel into a forward compartment, for a solid passage, and coaxial with saidpassage, and at the forward needle comprising cannula and hub. portions inasaid i sheath, cooperating rotation preventing lugs on the I exterior of said hub portion and int'eriorly of the needle shea th, to hold the hub against rotation while being applied to the needle holding tip; and a needle sheath c'ap -fittingover and in engagement with said sheath to protect the hypodermic needle against contamination during storage;

i end there'of a resilient valve sleeve, concentrically spaced 1 from the main portion of the piston; a plunger extending from the; rear into said barrelythe forward end of the plunger having 'thereon'a boss extending intothe axial passage in said piston, and having on said boss aNco-. a operating enlargement entering into and cooperating with the groove in the passage in said-piston, thereby firmly retainingthe"piston on said plungen'the plunger boss hav. ing such size as to extend into andlat least slightly exp and thevalve sleeve onthepiston, and in said plunger a liquid conduit extendingfrom theportion o'fthe plunger 3 i behind the piston injthe rear compartment to-the boss porpartment to the forward compartment ontrear' wa'rd movement of the plunger, causing 7 mixture of the solid ,andliquidg components, discharge of gas by f forward-rnoverneht of the plunger and pistomperrnit '1 needle, aspiration' as desired to f confirmia desire ation; of the hypodermie needle on insertion, and hypodermic ih 'ection'of the package contents; 7 all operations being sterilely -per'fornied.

-i 3 'Ai combination"aspirating hypodermic, syringfandf two-compartment package comprising a generally bylint" 'the' forwardienda transverse "wall, aneedleholdifng' tip barrel flange,- and i 1 v 1 th m pi tion of the plungerinside ofitheres'ilient Valve sleeve, and on the rear'jof the' unge'r a daexterior'of the barrel a lnnger's -the barreland the plunger toiform a liquid -tight se'al tl' erebetweenpmeans'to hol'd s'aid sealingjstopp'er in position; and'means to introduceEfair-into-"the rear V mpartment as the plunger moves.

I storage'positionJl. I

, S Q ACQmbination aspirat-iifghypodermic{ syringe o eornpartrnent; package comprising: i a generally cylindr 7, al-barreL havingat the rear end a barrel flange, and theforward: end a transverse-wall, a -needle holding-tip tendingjoutwardly 'frornsaid' wall, sai 'wallandtip he j'tip} storageg'fa re en the rear compartment asithe plunger moves forward e a'ling, opper cooperating with'the rear of orward of its 1 'erethrougha tip bore; "mean "to protect; the Y dividing the barrel into a forward compartment, for a solid component, and a rear com artment for a liquid component, and on said piston, at least one annular ring in sealing engagement with said barrel, said piston having therein an axial passage and coaxial with said passage, and at the forward end thereof a resilient valve sleeve, concentrically spaced from the main portion of the piston; a plunger extending from the rear into said barrel, the forward end of the plunger having hereon a boss extending into the axial passage in said piston, means to fixedly attach the plunger to said piston, the plunger boss having such size as to extend into and at least slightly expand the valve sleeve on the piston, and in said plunger a liquid conduit extending from the portion of the plunger behind the piston in the rear compartment to the boss portion of the plunger inside of the resilient valve sleeve, and on the rear of the plunger and exterior of the barrel a thumb piece; a plunger sealing stopper cooperating with the rear of the barrel and the plunger to form a liquidtight seal therebetween; means to hold said sealing stopper in position; and means to introduce air into the rear compartment as the plunger moves forward of its storage position.

6. A combination aspirating hypodermic syringe and two-compartment package comprising: a generally cylindrical barrel, having at the forward end a transverse wall, a needle holding tip extending outwardly from said wall, said Wall and tip having therethrough a tip bore; means to protect the sterility of the tip during storage; a resilient piston in said barrel and located towards the center of said barrel, dividing the barrel into a forward compartment, for a solid component, and a rear compartment for a liquid component, and on said piston, at least one annular ring in sealing engagement with said barrel, said piston having therein an axial passage and coaxial with said passage, and at the forward end thereof a resilient valve sleeve; a plunger extending from the rear into said barrel, the forward end of the plunger having thereon a boss extending into the axial passage in said piston, means to fixedly attach the plunger to said piston, the plunger boss having such size as to extend into and at least slightly expand the valve sleeve on the piston, and in said plunger a liquid conduit extending from the portion of the plunger behind the piston in the rear compartment to the boss portion of the plunger inside of the resilient valve sleeve, and on the rear of the plunger and exterior of the barrel a thumb piece; and means to retain liquid rearwardly of the piston.

7. In a hypodermic syringe and two-compartment package, having one compartment for a solid component, and a separate compartment for a liquid component, a combination one-way valve and piston assembly comprising a resilient one-piece piston having at least one annular ring for sealing engagement with the barrel of a hypoderrnic syringe to divide the barrel into said two com partments, said piston having therein an axial passage and an annular plunger retaining groove in said passage, and coaxial with said passage, and at the forward end thereof, a resilient valve sleeve concentrically spaced inwardly from the main portion of the piston, and approximately axially the same length as the main portion of the piston; and a separate plunger extending from the rear of the piston, the forward end of the plunger having thereon a boss extending into the axial passage in said piston, and having on said boss a cooperating enlargement entering into and cooperating with the groove in the passage in said piston, thereby firmly retaining the piston on said plunger, the plunger boss having such size as to extend into and at least slightly expand the valve sleeve on the piston, said plunger having a slot therein, which serves as a liquid conduit, extending from the portion of the plunger behind the piston to the boss portion of the plunger inside of the resilient valve sleeve, whereby liquid flows between the sleeve and the boss for oneway forward flow, but which sleeve contracts on the boss, preventing reverse flow.

Reterences Qited hy the Examiner UNITED STATES PATENTS 583,374 Hines May 25, 1897 1,499,508 Deane July 1, 1924 2,578,394 Blackman Dec. 11, 1951 2,677,374 Burnside May 4, 1954 3,021,942 Hamilton Feb. 20, 1962 3,952,239 Silver et a1 Sept. 4, 1962 3,076,456 Hunt Feb. 5, 1963 3,107,785 Roehr Get. 22, 1963 FOREIGN PATENTS 1,213,761 France Nov. 2, 1959 RICHARD A. GAUDET, Primary Examiner.

JORDAN FRANKLIN, Examiner.

Claims (1)

1. 7. IN A HYPODERMIC SYRINGE AND TWO-COMPARTMENT PACKAGE, HAVING ONE COMPARTMENT FOR A SOLID COMPONENT, AND A SEPARATE COMPARTMENT FOR A LIQUID COMPONENT, A COMBINATION ONE-WAY VALVE AND PISTON ASSEMBLY COMPRISING A RESILIENT ONE-PIECE PISTON HAVING AT LEAST ONE ANNULAR RING FOR SEALING ENGAGEMENT WITH THE BARREL OF A HYPODERMIC SYRINGE TO DIVIDE THE BARREL INTO SAID TWO COMPARTMENTS, SAID PISTON HAVING THEREIN AN AXIAL PASSAGE AND AN ANNULAR PLUNGER RETAINING GROOVE IN SAID PASSAGE, AND COAXIAL WITH SAID PASSAGE, AND AT THE FORWARD END THEREOF, A RESILIENT VALVE SLEEVE CONCENTRICALLY SPACED INWARDLY FROM THE MAIN PORTION OF THE PISTON, AND APPROXIMATELY AXIALLY THE SAME LENGTH AS THE MAIN PORTION OF THE PISTON; AND A SEPARATE PLUNGER EXTENDING FROM THE REAR OF THE PISTON, THE FORWARD END OF THE PLUNGER HAVING THEREON A BOSS EXTENDING INTO THE AXIAL PASSAGE IN SAID PISTON, AND HAVING ON SAID BOSS A COOPERATING ENLARGEMENT ENTERING INTO AND COOPERATING WITH THE GROOVE IN THE PASSAGE IN SAID PISTON, THEREBY FIRMLY RETAINING THE PISTON ON SAID PLUNGER, THE PLUNGER BOSS HAVING SUCH SIZE AS TO EXTEND INTO AND AT LEAST SLIGHTLY EXPAND THE VALVE SLEEVE ON THE PISTON, SAID PLUNGER HAVING A SLOT THEREIN, WHICH SERVES AS A LIQUID CONDUIT, EXTENDING FROM THE PORTION OF THE PLUNGER BEHIND THE PISTON TO THE BOSS PORTION OF THE PLUNGER INSIDE OF THE RESILIENT VALVE SLEEVE, WHEREBY LIQUID FLOWS BETWEEN THE SLEEVE AND THE BOSS FOR ONEWAY FORWARD FLOW, BUT WHICH SLEEVE CONTRACTS ON THE BOSS, PREVENTING REVERSE FLOW.

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