US3136440A - Self sealing pierceable stopper for sealed containers - Google Patents

Self sealing pierceable stopper for sealed containers Download PDF

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Publication number
US3136440A
US3136440A US290899A US29089963A US3136440A US 3136440 A US3136440 A US 3136440A US 290899 A US290899 A US 290899A US 29089963 A US29089963 A US 29089963A US 3136440 A US3136440 A US 3136440A
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United States
Prior art keywords
container
stopper
plug
self sealing
portion
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US290899A
Inventor
Albert E Krug
George H Keller
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Becton Dickinson and Co
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Becton Dickinson and Co
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Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Priority to US290899A priority Critical patent/US3136440A/en
Application granted granted Critical
Publication of US3136440A publication Critical patent/US3136440A/en
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Application status is Expired - Lifetime legal-status Critical

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082Test tubes per se
    • B01L3/50825Closing or opening means, corks, bungs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/15003Source of blood for venous or arterial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150351Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150389Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150473Double-ended needles, e.g. used with pre-evacuated sampling tubes
    • A61B5/150496Details of construction of hub, i.e. element used to attach the double-ended needle to a piercing device or sampling device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150732Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/153Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154Devices using pre-evacuated means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/002Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means

Description

June 9, 1964 A. E. KRUG ETAL 3,136,440

SELF SEALING PIERCEABLE STOPPER FOR SEALED CONTAINERS Filed June 25, 1963 INVENTORS. 4155,?! 5. l/IPUG 660/4 6! M K5440? III'TOIP/VEYJ United States Patent 3,136,440 SELF SEALING PIERCEABLE STOPPER FOR SEALED CONTAINERS Albert E. Krug, Wyclkolf, and George H. Keller, Ridgewood, N.J., assignors to Becton Dickinson and Company, East Rutherford, NJL, a corporation of New Jersey Filed June 25, 1963, Ser. No. 290,899 1 @laim. (Cl. 215-47) This invention relates to an improved self sealing pierceable stopper for sealed containers.

In the medical, biological and laboratory fields, sealed containers are frequently provided with pierceable self sealing stoppers whereby entry can be made into the container by means of a hypodermic needle so that fluids can be inserted in and removed from the container without breaking the sterility of the container. After the needle is removed from the stopper it immediately reseals. One type of stopper used'for this purpose is made of elastomeric material and is provided with a cylindrical plug portion, an enlarged head portion and a pierceable diaphragm extending across the stopper. Stoppers of this type have frequently been used with evacuated tubes and containers used in the collection of blood. This type of stopper has served very satisfactorily to provide the desired seal and to permit the insertion and removal of fluids. However, from time to time, difficulty has been encountered with the stopper in that it automatically escaped or ejected from the container breaking the sterility and causing contamination or loss of the contents.

It is a prime object of the present invention to provide an improved pierceable self sealing stopper of the above type which may be readily inserted in and removed from the opening in a container but which when inserted in the opening will remain firmly seated in place without danger of accidental release orejection.

Further objects include the provision of an improved pierceable self sealing stopper of the above type which is of relatively simple and inexpensive construction; which may be readily applied to and removed from a container and used in the same manner as stoppers of this type heretofore available; and which serves to preserve the seal and sterility of the container to which it is applied while permitting the insertion and removal of fluids by means of a hypodermic needle.

Our invention contemplates the provision of a self sealing pierceable stopper having a body portion made of elastomeric material and having a plug portion for inserting in the opening in the container and an enlarged head portion for engaging the outer end of the container. Around the plug portion immediately adjacent the enlarged head portion we provide a circumferential groove so as to relieve the stresses resulting from the resistance of the head portion to the compression of the plug. In accordance with a further aspect of our invention, recesses are provided at the opposite end of the stopper and the upper surface of the diaphragm is concave and the lower surface is convex thus directing the flow of the diaphragm material inwardly when the plug is compressed in insertion in the opening of a container.

In the accompanying drawing:

FIG. 1 is a side elevational view partially in section of a blood collecting assembly having a stopper embodying our invention applied to an evacuated tube or container;

FIG. 2 is an enlarged detailed view in section of the upper end of the container with the stopper applied thereto;

FIG. 3 is an exploded view in perspective of the stopper and the upper portion of the container; and

I by the fluids with which it is used. For this purpose we 3,136,440 Patented June 9, 1964 "ice FIG. 4 is a partially sectional side elevational view of the plug.

Our improved stopper is shown generally at 5. In FIGS. 1 and 2 it is illustrated as applied to the open upper end of a tubular container 6 which is closed at its lower end. The assembly illustrated is of the type frequently used in collecting blood specimens and the stopper has sealing engagement with the container and said container is at least partially evacuated so that blood will be drawn into the container when a cannula having connection with a bloodvessel is inserted therethrough.

Container 6 is preferably made of glass, but it may be made of a suitable plastic material inert to. and unaffected by the fluids to be collected therein. Assembled with the container and stopper in FIG. 1 is a holder 7 open at its lower end and of a size to have sliding fit with the container as shown. The holder 20 has a tapered top portion 8 formed with an aperture therethrough with which the hub-like fitting 9 has sealing engagement. A double ended cannula is mounted in sealing relationship with the hub-like fitting 9 with one end projecting into the holder and the other end projecting outwardly therefrom. In using the device illustrated in FIG. 1, the outwardly projecting portion of the cannula may be inserted into a blood vessel and then the inwardly projecting portion of the cannula is projected through the stopper with the result that blood is drawn into the sealed, evacuated container, 6. When the desired quantity .of blood has been drawn into the container, the cannula, in normal practice, is withdrawn from the stopper and then from the blood vessel. Upon withdrawal of the cannula from the stopper, it automatically reseals itself. It should be understood that the container maybe sterilized before its use in this fashion and that it may contain various blood treathave found that natural or synthetic rubber serves quite satisfactorily. Various elastomeric plastic compositions having the above indicated characteristics may also be employed under certain circumstances as, for instance,

the polymers and copolymers of vinylchloride or'vinyldienechloride.

The body portion of the stopper comprises a plug 10 having an enlarged head portion 12 integrally connected to the upper end thereof. The outside diameter of the plug 10 is slightly larger than the inside diameter of the opening in the container to which it is applied. Thus, when the plug is inserted into the open end of the container as shown in FIGS. 1 and 2, it is partially compressed. This helps to insure sealing engagement with the container as well as self sealing of the stopper when a cannula which has been inserted therethrough is withdrawn therefrom. The diameter of the head portion should be large enough to overlap the open upper end of the container as shown in FIGS. 1 and 2 so that it can be pressed into engagement therewith when the stopper is applied to the container. Recesses 14 and 16 are formed in the upper head end of the stopper and in the lower plug end of the stopper as shown. Extending across the stopper so as to overlap the area of connection between the head and plug portions is a diaphragm 18 also formed integrally with the remainder of the stopper. The diaphragm provides a partition or separation between the recesses 14 and 16 through which the cannula may be inserted when it is desired to add or remove fluid from the container. The upper surface of the diaphragm is preferably concave as shown at 20 and the lower surface is preferably convex as shown at 22. Thus, when the plug is compressed, the flow of the elastomeric material in the diaphragm is directed inwardly thereby minimizing stresses which might tend to eject or force the stopper outwardly from the container.

Around the outer surface of the plug, immediately adjacent the head 12, we provide a circumferential groove 24 which servesto minimize or relieve the stresses adjacent this portion of the plug resulting from the resistance of the head of the stopper to compression of the plug when it is inserted in the opening in the container. Thus, stresses in this area of the plug which tend to eject the stopper from the container are minimized or eliminated.

In order to facilitate the insertion of the plug end of the stopper into the opening of the container, we preferably taper the outer surface of the plug inwardly toward the free end thereof, as shown at 2 6. I

In using our improved stopper, it is applied to a container having an opening whose inside diameter is slightly less than the outside diameter of the plug portion. The plug is inserted in the opening as shown in FIGS. 1 and 2 with the head overlapping and pressed against the outer end of the container. Thus, the stopper provides a seal for the open end of the container; The container may be evacuated by inserting a hypodermic needle through the diaphragm 18 and drawing a vacuum therethrough or by inserting the stopper in the containers while in anevacuated chamber. When the needle is then withdrawn, the diaphragm is then self sealing. If the container is to be used for the collection of blood, blood drawing and preserving materials may be inserted therein. The sealed container may be sterilized in an autoclave in the usual manner. Liquids may be introduced into and withdrawn from the container by means of a hypodermic needle inserted through the diaphragm. In the collection of blood samples, the assembled container and stopper may be used with a holder of the type shovm at 7 in the manner described at the beginning of this specification.

When the stopper is assembled with the container in the manner illustrated and described, the plug 1G is partially compressed and the frictional engagement between the plug and container serves to hold the stopper in place against accidental displacement. Stresses and forces which might tend to eject the stopper from the container are relieved and minimized due to the provision of the circumferential groove 24 immediately adjacent the head and due to the concave-convex configuration of the diaphragm which directs the flow of elastomeric material inwardly when the plug is compressed; It will be seen .Cil

, 4 7, that the stopper is designed so that the maximum amount of rubber is disposed down inside the tube or container to firmly seal it in place.

Thus, we have provided an improved self sealing pierceable stopper for sealed containers which may be readily applied to containers but which will be firmly retained in place while the stopper is in use. It will also be seen that the stopper is of relatively simple and inexpensive construction and that it can be readily utilized'in the manner of self sealing pierceable stoppers heretofore available so as to provide sealing engagement with the container and at the same time permitting the insertion and removal of materials into and from the container without breaking the seal.

Modifications may be made in the illustrated and described embodiment of our invention without departing from the invention as set forth in the accompanying claim.

We claim:

A self sealing pierceable stopper for sealing containers of'the type having a tubular top with an opening therethrough which comprises: a body made of elastomeric material and comprising a cylindrical plug and an enlarged flange like head at the upper end thereof, said head and plug having recesses entering from the ends thereof with a diaphragm at the intermediate portion integral with said body and separating said recesses and connected across the upper portion of the plug and the lower portion of the head, said diaphragm having a concave'upper surface at the head end of the body with its central portion extending inwardly to a point adjacent the plane of the juncture between, the plug and head and'a convex lower surface at the plug end. and spaced from the plane of the juncture between the head and plug and the cylindrical plug having an outside diameter greater than the inside diameter of the opening in the container in which it is inserted so that the plug and diaphragm are partially compressed when inserted therein, asid plug having a circumferential groove extending completely around its outer surface immediately adjacent the head so as to relieve stresses of the plug resulting from resistance of said head-portion to compression of the plug and with the major portion of the diaphragm being positioned Within the plug so that when the plug is circumferentially compressed the elastomeric material in the diaphragm will flow inwardly in the direction of its convex surface.

References Cited in the file of this patent UNITED STATES PATENTS 2,836,320 Carroll May 27, 1958 2,923,427 Klopfenstein a Feb. 2, 1960 F REIGNPATENTS 552,472 Italy Dec. 3, 1956

US290899A 1963-06-25 1963-06-25 Self sealing pierceable stopper for sealed containers Expired - Lifetime US3136440A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US290899A US3136440A (en) 1963-06-25 1963-06-25 Self sealing pierceable stopper for sealed containers

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US290899A US3136440A (en) 1963-06-25 1963-06-25 Self sealing pierceable stopper for sealed containers
CH152464A CH410298A (en) 1963-06-25 1964-02-10 piercable self-sealing stopper for a container
GB5901/64D GB984149A (en) 1963-06-25 1964-02-12 Self sealing pierceable stopper for sealed containers
FR967401A FR1393651A (en) 1963-06-25 1964-03-13 Stopper pierceable self-sealed tube or sealed vials
DE1964B0075950 DE1498600C2 (en) 1963-06-25 1964-03-18 Self-sealing, pierceable plug of an elastomeric material

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US3136440A true US3136440A (en) 1964-06-09

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CH (1) CH410298A (en)
DE (1) DE1498600C2 (en)
FR (1) FR1393651A (en)
GB (1) GB984149A (en)

Cited By (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3653528A (en) * 1970-03-03 1972-04-04 West Co Stopper for medicament flasks
JPS4961384U (en) * 1972-09-04 1974-05-29
US3849072A (en) * 1972-04-25 1974-11-19 Becton Dickinson Co Plasma separator
US3941128A (en) * 1970-11-10 1976-03-02 Affiliated Hospital Products, Inc. Fluid dispensing arrangement
US3958572A (en) * 1974-12-16 1976-05-25 Corning Glass Works Blood collecting and separating assembly stopper
US4111326A (en) * 1976-03-04 1978-09-05 Becton, Dickinson And Company Closure for air evacuated container
US4181233A (en) * 1978-11-15 1980-01-01 Becton, Dickinson And Company One-way valve stopper
US4186840A (en) * 1976-03-04 1980-02-05 Becton, Dickinson And Company Cannulapierceable, self-sealing closure
US4236647A (en) * 1979-01-15 1980-12-02 Kotturan Paulson A Container for sterile liquids
US4254884A (en) * 1978-10-20 1981-03-10 Toppan Printing Co., Ltd. Plug body for a container
JPS5666244A (en) * 1979-11-01 1981-06-04 Becton Dickinson Co Vacuum display closure for sampling blood
US4385637A (en) * 1979-04-02 1983-05-31 American Hospital Supply Corporation Blood sampler
US4444330A (en) * 1981-10-02 1984-04-24 Terumo Kabushiki Kaisha Medical container stopper
EP0174032A2 (en) * 1984-09-07 1986-03-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Medical container stopper
US4671331A (en) * 1986-03-13 1987-06-09 Lyphomed, Inc. Cover for medicinal vial
US4682703A (en) * 1985-04-25 1987-07-28 Terumo Kabushiki Kaisha Stopper for medical container
US4735832A (en) * 1984-05-11 1988-04-05 Terumo Kabushiki Kaisha Container made of synthetic resin and method for manufacture thereof
US4741446A (en) * 1986-12-29 1988-05-03 Becton, Dickinson And Company Computer generated stopper
US4893636A (en) * 1988-03-09 1990-01-16 Sherwood Medical Company Medical container stopper
US5088995A (en) * 1990-06-22 1992-02-18 Baxter International Inc. Port and closure assembly including a resealing injection site for a container
US5257529A (en) * 1990-12-28 1993-11-02 Nissho Corporation Method and device for measurement of viscosity of liquids
EP1064879A1 (en) * 1998-03-18 2001-01-03 Sekisui Chemical Co., Ltd. Plug body for vacuum specimen sampling container, vacuum specimen sampling container, vacuum specimen sampling system, vacuum specimen sampling holder, and thermoplastic elastomer composition for plug body
EP1182143A3 (en) * 2000-08-25 2002-05-08 Daikyo Seiko, Ltd. Closure for vial
US20030083606A1 (en) * 1998-06-03 2003-05-01 Epstein Gordon Howard Direct dual filling device for sealing agents
US20030088216A1 (en) * 2001-10-03 2003-05-08 Daniel Py Syringe and reconstitution syringe
US20030096428A1 (en) * 2001-10-30 2003-05-22 Bruker Daltonik Gmbh Sampler for dust on surfaces
US20030201239A1 (en) * 2002-04-25 2003-10-30 Medtronic Minimed, Inc. Radially compressed self-sealing septum
US6672345B2 (en) 2001-10-06 2004-01-06 Sarstedt Ag Apparatus for forming a vacuum in a blood tube
US20040060261A1 (en) * 2002-06-19 2004-04-01 Daniel Py Sterile filling machine having needle filling station within e-beam chamber
US20040086428A1 (en) * 1999-04-20 2004-05-06 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
US20040141886A1 (en) * 2000-02-11 2004-07-22 Daniel Py Sealed containers and methods of making and filling same
US20040245289A1 (en) * 2000-10-23 2004-12-09 Daniel Py Fluid dispenser having a housing and flexible inner bladder
US20040256026A1 (en) * 2000-02-11 2004-12-23 Daniel Py Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
US20050000591A1 (en) * 2003-05-12 2005-01-06 Daniel Py Dispenser and apparatus and method for filling a dispenser
US20050178462A1 (en) * 2003-04-28 2005-08-18 Daniel Py Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
US20050215943A1 (en) * 2002-05-27 2005-09-29 Torsten Brandenburger Connector for packaging containing medical fluids and packaging for medical fluids
US20050263543A1 (en) * 2001-10-16 2005-12-01 Daniel Py Dispenser with sealed chamber, one-way valve and needle penetrable and laser resealable stopper
US6976509B1 (en) * 2004-08-02 2005-12-20 Kirvan Clifford J Method and apparatus for pressurizing plastic pipe
US20060191594A1 (en) * 2000-02-11 2006-08-31 Daniel Py Device with needle penetrable and laser resealable portion and related method
US7264142B2 (en) 2004-01-27 2007-09-04 Medical Instill Technologies, Inc. Dispenser having variable-volume storage chamber and depressible one-way valve assembly for dispensing creams and other substances
US20070284330A1 (en) * 2006-06-07 2007-12-13 J.G. Finneran Associates, Inc. Two-piece seal vial assembly
US20080011375A1 (en) * 2006-07-13 2008-01-17 Robert Bosch Gmbh Combination cap and plug
US20090048534A1 (en) * 2005-06-08 2009-02-19 Daniele Triva Device for the Withdrawal, collection and Transport of Biological Specimens
US20090308184A1 (en) * 2008-03-05 2009-12-17 Becton, Dickinson And Company Co-Molded Pierceable Stopper and Method for Making the Same
US7798185B2 (en) 2005-08-01 2010-09-21 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile food product
US20120141341A1 (en) * 2010-12-03 2012-06-07 Becton, Dickinson And Company Specimen Collection Container Assembly
US8211081B2 (en) 2004-10-20 2012-07-03 Fresenius Kabi Deutschland Gmbh Closing cap for containers filled with medical liquids
WO2013019157A1 (en) * 2011-07-29 2013-02-07 Wikner Johan Stopper sample container and method of measurement using said stopper
US8672195B2 (en) 2002-08-13 2014-03-18 Medical Instill Technologies, Inc. Device with chamber and first and second valves in communication therewith, and related method
US8757436B2 (en) 2000-10-23 2014-06-24 Medical Instill Technologies, Inc. Method for dispensing ophthalmic fluid
USD779081S1 (en) 2013-09-06 2017-02-14 Theranos, Inc. Sample container
EP3536631A1 (en) * 2018-03-06 2019-09-11 INGE S.p.A. Device for capping a bottle suited to the preservation of substances to be kept separate until their application and suited to the collection of the mixture obtained by means of a syringe
US10488160B2 (en) 2017-12-01 2019-11-26 Joseph D. La Scola Firearms target

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2488854A1 (en) * 1980-08-19 1982-02-26 Sherwood Medical Ind Inc Coated stoppers for blood containers - have layer of anticoagulant on layer of coupling agent
NL8701405A (en) * 1987-06-17 1989-01-16 Hendrik Kruijswijk Dr Protection for blood collection systems.
DE3744173A1 (en) * 1987-12-24 1989-07-06 Helvoet Pharma Lyophilization stoppers
US4874102A (en) * 1988-05-09 1989-10-17 Multi-Technology Inc. Medical fail safe releasible locks and/or seals for capped disposable centrifuge containers, cryogenic vials and the like
DE9006079U1 (en) * 1990-05-30 1990-09-13 Bethkenhagen, Juergen, 5223 Nuembrecht, De
AT500525A1 (en) * 2003-04-17 2006-01-15 Greiner Bio One Gmbh Receiving device and sealing device and cap shaped locking device
US7707807B2 (en) 2004-03-08 2010-05-04 Medical Instill Technologies, Inc. Apparatus for molding and assembling containers with stoppers and filling same
US7669390B2 (en) 2004-03-08 2010-03-02 Medical Instill Technologies, Inc. Method for molding and assembling containers with stoppers and filling same
ES2524774T3 (en) 2005-10-17 2014-12-12 Medical Instill Technologies, Inc. Apparatus and method of sterile demoulding
EP2213374A1 (en) * 2009-01-15 2010-08-04 Syntesys sas Cap for repeated closing of test-tubes
GB2483055A (en) * 2010-08-19 2012-02-29 Baxter Int Administration port for medical fluid containers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2836320A (en) * 1956-09-13 1958-05-27 Sterling Drug Inc Sterile ampule package
US2923427A (en) * 1956-05-04 1960-02-02 Klopfenstein Florenc Stoianoff Closure for hypodermic solution containers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2923427A (en) * 1956-05-04 1960-02-02 Klopfenstein Florenc Stoianoff Closure for hypodermic solution containers
US2836320A (en) * 1956-09-13 1958-05-27 Sterling Drug Inc Sterile ampule package

Cited By (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3653528A (en) * 1970-03-03 1972-04-04 West Co Stopper for medicament flasks
US3941128A (en) * 1970-11-10 1976-03-02 Affiliated Hospital Products, Inc. Fluid dispensing arrangement
US3849072A (en) * 1972-04-25 1974-11-19 Becton Dickinson Co Plasma separator
JPS4961384U (en) * 1972-09-04 1974-05-29
US3958572A (en) * 1974-12-16 1976-05-25 Corning Glass Works Blood collecting and separating assembly stopper
US4290534A (en) * 1976-03-04 1981-09-22 Becton, Dickinson And Company Cannula pierceable self-sealing closure
US4111326A (en) * 1976-03-04 1978-09-05 Becton, Dickinson And Company Closure for air evacuated container
US4136794A (en) * 1976-03-04 1979-01-30 Becton, Dickinson And Company Cannula pierceable, self-sealing closure
US4186840A (en) * 1976-03-04 1980-02-05 Becton, Dickinson And Company Cannulapierceable, self-sealing closure
US4187952A (en) * 1976-03-04 1980-02-12 Becton, Dickinson And Company Cannula pierceable, self-sealing closure
US4226333A (en) * 1976-03-04 1980-10-07 Becton, Dickinson And Company Cannula pierceable self-sealing closure
US4295572A (en) * 1976-03-04 1981-10-20 Becton, Dickinson And Company Cannula pierceable self-sealing closure
US4301936A (en) * 1976-03-04 1981-11-24 Becton, Dickinson And Company Cannula pierceable self-sealing closure
US4254884A (en) * 1978-10-20 1981-03-10 Toppan Printing Co., Ltd. Plug body for a container
US4181233A (en) * 1978-11-15 1980-01-01 Becton, Dickinson And Company One-way valve stopper
US4236647A (en) * 1979-01-15 1980-12-02 Kotturan Paulson A Container for sterile liquids
US4385637A (en) * 1979-04-02 1983-05-31 American Hospital Supply Corporation Blood sampler
JPS5666244A (en) * 1979-11-01 1981-06-04 Becton Dickinson Co Vacuum display closure for sampling blood
JPS6149974B2 (en) * 1979-11-01 1986-10-31 Becton Dickinson Co
FR2542612A1 (en) * 1981-10-02 1984-09-21 Terumo Corp Cap for medical bottle
US4444330A (en) * 1981-10-02 1984-04-24 Terumo Kabushiki Kaisha Medical container stopper
US4735832A (en) * 1984-05-11 1988-04-05 Terumo Kabushiki Kaisha Container made of synthetic resin and method for manufacture thereof
EP0174032A2 (en) * 1984-09-07 1986-03-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Medical container stopper
US4664275A (en) * 1984-09-07 1987-05-12 Terumo Kabushiki Kaisha Medical container stopper
EP0174032A3 (en) * 1984-09-07 1988-05-04 Terumo Kabushiki Kaisha Trading As Terumo Corporation Medical container stopper
US4682703A (en) * 1985-04-25 1987-07-28 Terumo Kabushiki Kaisha Stopper for medical container
US4671331A (en) * 1986-03-13 1987-06-09 Lyphomed, Inc. Cover for medicinal vial
US4741446A (en) * 1986-12-29 1988-05-03 Becton, Dickinson And Company Computer generated stopper
JPS63178956A (en) * 1986-12-29 1988-07-23 Becton Dickinson Co Computer preparing stopper and preparation thereof
US4991104A (en) * 1986-12-29 1991-02-05 Becton, Dickinson And Company Computer generated stopper
JPH0669821B2 (en) 1986-12-29 1994-09-07 ベクトン・ディッキンソン・アンド・カンパニー Sealing assembly of the container
US4893636A (en) * 1988-03-09 1990-01-16 Sherwood Medical Company Medical container stopper
US5060659A (en) * 1988-03-09 1991-10-29 Sherwood Medical Company Medical container stopper
US5088995A (en) * 1990-06-22 1992-02-18 Baxter International Inc. Port and closure assembly including a resealing injection site for a container
US5257529A (en) * 1990-12-28 1993-11-02 Nissho Corporation Method and device for measurement of viscosity of liquids
EP1064879A1 (en) * 1998-03-18 2001-01-03 Sekisui Chemical Co., Ltd. Plug body for vacuum specimen sampling container, vacuum specimen sampling container, vacuum specimen sampling system, vacuum specimen sampling holder, and thermoplastic elastomer composition for plug body
EP1064879A4 (en) * 1998-03-18 2006-08-02 Sekisui Chemical Co Ltd Plug body for vacuum specimen sampling container, vacuum specimen sampling container, vacuum specimen sampling system, vacuum specimen sampling holder, and thermoplastic elastomer composition for plug body
US20030083606A1 (en) * 1998-06-03 2003-05-01 Epstein Gordon Howard Direct dual filling device for sealing agents
US7081103B2 (en) * 1998-06-03 2006-07-25 Baxter International Inc. Direct dual filling device for sealing agents
US20040086428A1 (en) * 1999-04-20 2004-05-06 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
US7318913B2 (en) * 1999-04-20 2008-01-15 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
US8173068B2 (en) 1999-04-20 2012-05-08 Dako Denmark A/S Fluid exchange in a chamber on a microscope slide
US20080056954A1 (en) * 1999-04-20 2008-03-06 Loeffler Herbert H Fluid exchange in a chamber on a microscope slide
US7726357B2 (en) 2000-02-11 2010-06-01 Medical Instill Technologies, Inc. Resealable containers and assemblies for filling and resealing same
US20040141886A1 (en) * 2000-02-11 2004-07-22 Daniel Py Sealed containers and methods of making and filling same
US7967034B2 (en) 2000-02-11 2011-06-28 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US20040256026A1 (en) * 2000-02-11 2004-12-23 Daniel Py Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
US7980276B2 (en) 2000-02-11 2011-07-19 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US9549874B2 (en) 2000-02-11 2017-01-24 Medinstill Development Llc Device with penetrable and resealable portion and related method
US7810529B2 (en) 2000-02-11 2010-10-12 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion
US20100236659A1 (en) * 2000-02-11 2010-09-23 Daniel Py Resealable Containers and Methods of Making, Filling and Resealing Same
US20100236193A1 (en) * 2000-02-11 2010-09-23 Daniel Py Sealed Containers and Methods of Filing and Resealing Same
US7726352B2 (en) 2000-02-11 2010-06-01 Medical Instill Technologies, Inc. Sealed containers and methods of making and filling same
US7992597B2 (en) 2000-02-11 2011-08-09 Medical Instill Technologies, Inc. Sealed containers and methods of filling and resealing same
US9637251B2 (en) 2000-02-11 2017-05-02 Medinstill Development Llc Sealed containers and methods of filling and resealing same
US20090229702A1 (en) * 2000-02-11 2009-09-17 Daniel Py Device with needle penetrable and laser resealable portion and related method
US7500498B2 (en) 2000-02-11 2009-03-10 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US7032631B2 (en) 2000-02-11 2006-04-25 Medical Instill Technologies, Inc. Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
US7490639B2 (en) 2000-02-11 2009-02-17 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US7445033B2 (en) 2000-02-11 2008-11-04 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US9051064B2 (en) 2000-02-11 2015-06-09 Medinstill Development Llc Resealable containers and methods of making, filling and resealing same
US8631838B2 (en) 2000-02-11 2014-01-21 Medical Instill Technologies, Inc. Device with penetrable and resealable portion and related method
US7243689B2 (en) 2000-02-11 2007-07-17 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US7100646B2 (en) 2000-02-11 2006-09-05 Medical Instill Technologies, Inc. Sealed containers and methods of making and filling same
US20080072996A1 (en) * 2000-02-11 2008-03-27 Daniel Py Device with Needle Penetrable and Laser Resealable Portion and Related Method
US20070000573A1 (en) * 2000-02-11 2007-01-04 Daniel Py Sealed containers and methods of making and filling same
US20080066824A1 (en) * 2000-02-11 2008-03-20 Daniel Py Device with needle penetrable and laser resealable portion and related method
US20080053561A1 (en) * 2000-02-11 2008-03-06 Daniel Py Device with needle penetrable and laser resealable portion and related method
US8347923B2 (en) 2000-02-11 2013-01-08 Medical Instill Technologies, Inc. Device with penetrable and resealable portion and related method
US8960242B2 (en) 2000-02-11 2015-02-24 Medinstill Development Llc Sealed containers and methods of filling and resealing same
US20060191594A1 (en) * 2000-02-11 2006-08-31 Daniel Py Device with needle penetrable and laser resealable portion and related method
EP1182143A3 (en) * 2000-08-25 2002-05-08 Daikyo Seiko, Ltd. Closure for vial
US9668914B2 (en) 2000-10-23 2017-06-06 Dr. Py Institute Llc Method for dispensing ophthalmic fluid
US8240521B2 (en) 2000-10-23 2012-08-14 Medical Instill Technologies, Inc. Fluid dispenser having a one-way valve, pump, variable-volume storage chamber, and a needle penetrable and laser resealable portion
US8757436B2 (en) 2000-10-23 2014-06-24 Medical Instill Technologies, Inc. Method for dispensing ophthalmic fluid
US20040245289A1 (en) * 2000-10-23 2004-12-09 Daniel Py Fluid dispenser having a housing and flexible inner bladder
US9725228B2 (en) 2000-10-23 2017-08-08 Dr. Py Institute Llc Fluid dispenser having a one-way valve, pump, variable-volume storage chamber, and a needle penetrable and laser resealable portion
US7000806B2 (en) 2000-10-23 2006-02-21 Medical Instill Technologies, Inc. Fluid dispenser having a housing and flexible inner bladder
US20030088216A1 (en) * 2001-10-03 2003-05-08 Daniel Py Syringe and reconstitution syringe
US20070156102A1 (en) * 2001-10-03 2007-07-05 Daniel Py Syringe and reconstitution syringe
US7186241B2 (en) 2001-10-03 2007-03-06 Medical Instill Technologies, Inc. Syringe with needle penetrable and laser resealable stopper
US7779609B2 (en) 2001-10-03 2010-08-24 Medical Instill Technologies, Inc. Method of filling a device
US20100276035A1 (en) * 2001-10-03 2010-11-04 Daniel Py Device with penetrable and resealable portion
US6672345B2 (en) 2001-10-06 2004-01-06 Sarstedt Ag Apparatus for forming a vacuum in a blood tube
US9630755B2 (en) 2001-10-16 2017-04-25 Medinstill Development Llc Dispenser and method for storing and dispensing sterile product
US7290573B2 (en) 2001-10-16 2007-11-06 Medical Instill Technologies, Inc. Dispenser with sealed chamber, one-way valve and needle penetrable and laser resealable stopper
US8220507B2 (en) 2001-10-16 2012-07-17 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile product
US20050263543A1 (en) * 2001-10-16 2005-12-01 Daniel Py Dispenser with sealed chamber, one-way valve and needle penetrable and laser resealable stopper
US20030096428A1 (en) * 2001-10-30 2003-05-22 Bruker Daltonik Gmbh Sampler for dust on surfaces
US6898991B2 (en) * 2001-10-30 2005-05-31 Bruker Daltonik Gmbh Sampler for dust on surfaces
US20030201239A1 (en) * 2002-04-25 2003-10-30 Medtronic Minimed, Inc. Radially compressed self-sealing septum
US8118802B2 (en) 2002-05-27 2012-02-21 Fresenius Kabi Deutschland Gmbh Connector for packaging containing medical fluids and packaging for medical fluids
US20050215943A1 (en) * 2002-05-27 2005-09-29 Torsten Brandenburger Connector for packaging containing medical fluids and packaging for medical fluids
US20110022024A1 (en) * 2002-05-27 2011-01-27 Fresenius Kabi Deutschland Gmbh Connector for packaging containing medical fluids and packaging for medical fluids
US7828787B2 (en) 2002-05-27 2010-11-09 Fresenius Kabi Deutschland Gmbh Connector for packaging containing medical fluids and packaging for medical fluids
US20070079896A1 (en) * 2002-06-19 2007-04-12 Daniel Py Sterile filling machine having needle filling station within e-beam chamber
US6929040B2 (en) 2002-06-19 2005-08-16 Medical Instill Technologies, Inc. Sterile filling machine having needle filling station within e-beam chamber
US7111649B2 (en) 2002-06-19 2006-09-26 Medical Instill Technologies, Inc. Sterile filling machine having needle filling station within e-beam chamber
US8448674B2 (en) 2002-06-19 2013-05-28 Medical Instill Technologies, Inc. Sterile filling machine having filling station and E-beam chamber
US7556066B2 (en) 2002-06-19 2009-07-07 Medical Instill Technologies, Inc. Sterile filling machine having needle filling station and conveyor
US20040060261A1 (en) * 2002-06-19 2004-04-01 Daniel Py Sterile filling machine having needle filling station within e-beam chamber
US9296498B2 (en) 2002-06-19 2016-03-29 Medinstill Development Llc Methods of filling a sealed device
US20090308485A1 (en) * 2002-06-19 2009-12-17 Daniel Py Sterile Filling Machine Having Needle Filling Station and Conveyor
US7905257B2 (en) 2002-06-19 2011-03-15 Daniel Py Sterile filling machine having needle filling station and conveyor
US20050173020A1 (en) * 2002-06-19 2005-08-11 Daniel Py Sterile filling machine having needle filling station within E-Beam chamber
US8672195B2 (en) 2002-08-13 2014-03-18 Medical Instill Technologies, Inc. Device with chamber and first and second valves in communication therewith, and related method
US7568509B2 (en) 2003-04-28 2009-08-04 Medical Instill Technologies, Inc. Container with valve assembly, and apparatus and method for filling
US20070084524A1 (en) * 2003-04-28 2007-04-19 Daniel Py Container with valve assembly, and apparatus and method for filling
US20050178462A1 (en) * 2003-04-28 2005-08-18 Daniel Py Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
US7077176B2 (en) 2003-04-28 2006-07-18 Medical Instill Technologies, Inc. Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
US8272411B2 (en) 2003-04-28 2012-09-25 Medical Instill Technologies, Inc. Lyophilization method and device
US7328729B2 (en) 2003-05-12 2008-02-12 Medical Instill Technologies, Inc. Dispenser and apparatus and method for filling a dispenser
US6997219B2 (en) 2003-05-12 2006-02-14 Medical Instill Technologies, Inc. Dispenser and apparatus and method for filling a dispenser
US9963288B2 (en) 2003-05-12 2018-05-08 Maej Llc Dispenser and apparatus and method for filling a dispenser
US8627861B2 (en) 2003-05-12 2014-01-14 Medical Instill Technologies, Inc. Dispenser and apparatus and method for filling a dispenser
US20050000591A1 (en) * 2003-05-12 2005-01-06 Daniel Py Dispenser and apparatus and method for filling a dispenser
US20060124197A1 (en) * 2003-05-12 2006-06-15 Medical Instill Technologies, Inc. Dispenser and apparatus and method for filling a dispenser
US7861750B2 (en) 2003-05-12 2011-01-04 Medical Instill Technologies, Inc. Dispenser and apparatus and method of filling a dispenser
US8413854B2 (en) 2004-01-27 2013-04-09 Medical Instill Technologies, Inc. Dispenser with variable-volume storage chamber, one-way valve, and manually-depressible actuator
US8919614B2 (en) 2004-01-27 2014-12-30 Medinstill Development Llc Dispenser with variable-volume storage chamber, one-way valve, and manually-depressible actuator
US9377338B2 (en) 2004-01-27 2016-06-28 Medinstill Development Llc Dispenser with variable-volume storage chamber, one-way valve, and manually-depressible actuator
US7644842B2 (en) 2004-01-27 2010-01-12 Medical Instill Technologies, Inc. Dispenser having variable-volume storage chamber and depressible one-way valve assembly for dispensing creams and other substances
US7264142B2 (en) 2004-01-27 2007-09-04 Medical Instill Technologies, Inc. Dispenser having variable-volume storage chamber and depressible one-way valve assembly for dispensing creams and other substances
US7886937B2 (en) 2004-01-27 2011-02-15 Medical Instill Technologies, Inc. Dispenser with variable-volume storage chamber, one-way valve, and manually-depressible actuator
US6976509B1 (en) * 2004-08-02 2005-12-20 Kirvan Clifford J Method and apparatus for pressurizing plastic pipe
US8211081B2 (en) 2004-10-20 2012-07-03 Fresenius Kabi Deutschland Gmbh Closing cap for containers filled with medical liquids
US20090048534A1 (en) * 2005-06-08 2009-02-19 Daniele Triva Device for the Withdrawal, collection and Transport of Biological Specimens
US7798185B2 (en) 2005-08-01 2010-09-21 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile food product
US7934614B2 (en) * 2006-06-07 2011-05-03 J. G. Finneran Associates, Inc. Two-piece seal vial assembly
US20070284330A1 (en) * 2006-06-07 2007-12-13 J.G. Finneran Associates, Inc. Two-piece seal vial assembly
US20080011375A1 (en) * 2006-07-13 2008-01-17 Robert Bosch Gmbh Combination cap and plug
US20090308184A1 (en) * 2008-03-05 2009-12-17 Becton, Dickinson And Company Co-Molded Pierceable Stopper and Method for Making the Same
US8806920B2 (en) 2008-03-05 2014-08-19 Becton, Dickinson And Company Co-molded pierceable stopper and method for making the same
CN103237602A (en) * 2010-12-03 2013-08-07 贝克顿·迪金森公司 Specimen collection container assembly
US9399218B2 (en) * 2010-12-03 2016-07-26 Becton, Dickinson And Company Specimen collection container assembly
US20120141341A1 (en) * 2010-12-03 2012-06-07 Becton, Dickinson And Company Specimen Collection Container Assembly
CN103237602B (en) * 2010-12-03 2015-09-16 贝克顿·迪金森公司 Specimen collection container assembly
US9962704B2 (en) 2010-12-03 2018-05-08 Becton, Dickinson And Company Specimen collection container assembly
US8460620B2 (en) * 2010-12-03 2013-06-11 Becton, Dickinson And Company Specimen collection container assembly
WO2013019157A1 (en) * 2011-07-29 2013-02-07 Wikner Johan Stopper sample container and method of measurement using said stopper
USD779081S1 (en) 2013-09-06 2017-02-14 Theranos, Inc. Sample container
US10488160B2 (en) 2017-12-01 2019-11-26 Joseph D. La Scola Firearms target
EP3536631A1 (en) * 2018-03-06 2019-09-11 INGE S.p.A. Device for capping a bottle suited to the preservation of substances to be kept separate until their application and suited to the collection of the mixture obtained by means of a syringe

Also Published As

Publication number Publication date
DE1498600B1 (en) 1970-03-26
CH410298A (en) 1966-03-31
FR1393651A (en) 1965-03-26
GB984149A (en) 1965-02-24
DE1498600C2 (en) 1970-03-26

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