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Aspirating piston and plunger coupling

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US3115135A
US3115135A US17908562A US3115135A US 3115135 A US3115135 A US 3115135A US 17908562 A US17908562 A US 17908562A US 3115135 A US3115135 A US 3115135A
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Prior art keywords
plunger
piston
cartridge
end
bore
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Stanley J Sarnoff
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Stanley J Sarnoff
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403Ampoule inserted into the ampoule holder
    • A61M2005/2407Ampoule inserted into the ampoule holder from the rear
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403Ampoule inserted into the ampoule holder
    • A61M2005/2411Ampoule inserted into the ampoule holder from the front
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2433Ampoule fixed to ampoule holder
    • A61M2005/2437Ampoule fixed to ampoule holder by clamping means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2433Ampoule fixed to ampoule holder
    • A61M2005/2444Ampoule fixed to ampoule holder by thread
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485Ampoule holder connected to rest of syringe
    • A61M2005/2496Ampoule holder connected to rest of syringe via pivot

Description

Dec- 24, 1963 s. J. sARNox-F ASPIRATING PIsToN AND PLUNGER couPLING Filed March 12, 1962 Mmmm INVENTOR.

J. Sarnoff ATTORNEY United States Patent Olice 3,ll5,l35 Patented Bec. 24, 1%63 3,115,35 ASIIRATENG PISTN AND PLUNGER CUPLING Stanley l'. Sarnoif, 3 Paolis Hill Road, Bethesda 14, Md. Filed Mar. 12, 1962, Ser. No. 179,085 9 Claims. (Cl. 12S- 213) This invention relates to a hypoderrnic cartridge holder and associated cartridge.

In a common form of hypodermic injection apparatus, there is provided a one-use cartridge of medicament. This cartridge usually includes a hollow needle at one end thereof and a piston at the other end, with fluid medicament therebetween. When the cartridge is inserted within a cartridge holder, a plunger forming part of the holder may be coupled with the piston and then forced in to move the piston toward the needle to expel the fluid content of the cartridge through the needle.

It is an object of this invention, in such a device, to provide for automatic coupling and decoupling of the piston and plunger.

It is a further object of the invention to provide in such an automatic coupling and decoupling device a structure to enable withdrawal or aspirating movement of the piston, after the needle has been inserted into the body of a patient, to ascertain whether the needle has been inserted into a vein or artery.

Other objects will be made clear upon consideration of the following specification when taken in conjunction with the accompanying drawings in which:

FIG. 1 is a plan View, partly in section, of one form of holder embodying a plunger and coupling arrangement of the invention;

FIG. 2 is a plan view of a cartridge embodying a piston coupling forming part of the invention;

FIG. 3 is a plan View and partly in section, of a modifled form of holder and cartridge embodying the invention, showing the cartridge partially inserted in the holder and in coupled relationship to the plunger;

FIG. 4 is a view of the parts of FIG. 3, with the cartridge in operative position and the plunger coupled to the piston;

FIG. 5 is a plan View of the plunger, partly in section;

FIG. 6 is an end view of the coupling end of the plunger;

FIG. 7 is a plan view of a button forming part of the coupling means;

FIG. 8 is a plan View, partly in section, of the coupling end of a different form of plunger.

Referring to the drawings with greater particularity, in FIGS. l and 2 there are illustrated a holder 10 and a cartridge 12.

The holder comprises a barrel 14 which may be windowed as at 16 to expose a cartridge therewithin and provided at one end with an internally threaded opening 1S to threadedly receive the threads Ztl on the needle end of the cartridge 12. The opposite end of the barrel is open and its outer wall is provided with two diametrically opposed pins 22 pivoting a hub 24 by means of two legs 26 integral with the hub, straddling the barrel and pivoted on the pins. The hub may further be provided with finger pieces 28 for convenience in manipulation of the holder. Reciprocable in -a bore 29 centrally located in the hub is a plunger 3i), the bore in the hub being of a size to snugly slidably accommodate the plunger, especially the right-hand end thereof, as seen in FIG. 1.

The cartridge 12 comprises a glass or plastic tube 32 containing a fluid medicament 33 and mounting a hollow needle 34 at one end with its passageway in communication with the medicament in the tube. The other end of the tube has within it a resilient piston 35 provided with a centrally located coupling button indicated generically as 36.

When the plunger is withdrawn through the hub to the right as shown in FIG. 1, and the hub is rotated on its pivotal mounting to swing it away from over the open end of the barrel, the cartridge l2 is inserted into the barrel, needle end first, and the cartridge and barrel are manipulated to threadedly engage the parts 18 and Ztl. Then the hub is swung back into alignment with the barrel and the plunger 3i) is thrust in to automatically engage the inner end of the plunger with the button. This is possible because of the construction and central position of the plunger and button. The plunger comprises a metal or plastic rod having a thumb piece 40 at one end and a forked opposite end. While the furcations may be of any number, for convenience in further description of the invention, the plunger is described as bifurcated. The furcations extend for a considerable distance from said opposite end to provide, in the form of invention illustrated, two tines i2 which are normally biased by inherent resiliency to cause the free ends of the tines to spring apart. FIG. 5 shows the tines in the divergent relationship that they assume when the plunger, shown, for example, in FIG. l, is thrust to its furthermost left-hand position in that ligure.

Referring to FIGS. 5 and 6, it will be seen that each of the tines at its end has an arcuate jaw 44, almost semicircular in extent, with a slight gap between the jaws. The jaws have an internal space 46 of a diameter to t snugly about a conical head 49 forming part of the button 36 with the inturned ends of the fingers 4% snugly embracing the neck portion 56 of the button. The underside 52 of the head 49 is perpendicular to the longitudinal axis of the button and to the length of the piston. The inside faces of the fingers, indicated at 54 in FIG. 5 are parallel to the underface of the head 49 of the button when the plunger and button are coupled together. The button itself is of rigid material, as metal, hard rubber or plastic, coupled into the softer resilient material of the piston, with a face of a flange S6 on the button extending slightly above the adjacent face of the piston and with a neck 58 and a second head 6@ ernbedded in the resilient material of the piston, the head dit having a surface perpendicular to the length of the piston, said head, therefore, resisting pulling the button out of the piston, the ilange 56 resisting thrust of the button into the piston.

Reverting to FIGS. 1 and 2, when the cartridge has been positioned in the barrel and the hub rotated to bring the plunger over the cartridge and in alignment with the button, the plunger is moved in a distance until the fingers 48 engage the conical head 49 of the button SI5. At this time there is a portion of the plunger between the hub and the button relatively free of lateral restraint, enabling the tines, on further thrust on the plunger, to be sprung apart by the conical head, notwithstanding the holding together of the tines at a position further back along the plunger by the bore in the hub, and then snap under the head into locking engagement with the button. The bore 29, as has already been described, snugly slidably accommodates the plunger, and therefore the tines, when the plunger is retracted or drawn to the right, see FIG. 1, are forced into parallelism thus maintaining the coupling engagement of the plunger and piston. After initial movement of the plunger so as to effect coupling between the plunger and the piston, and after the needle has been inserted into a patient, the piston may be withdrawn by limited plunger retraction to determine whether the needle is in communication with a vein or an artery. Thus, within a substantial range of movement of the piston from its initial position at the right-hand end of the barrel, the piston may be reciprocated by the plunger, at will, without decoupling.

The piston may be thrust, by plunger action, toward the needle, the finger end of the plunger thrusting against the ilange 56 of the button. As the plunger is thrust forward, and when the piston is at or near the needle end of the cartridge, the bifurcated portion of the plunger leaves the hub and the tines are free to diverge under their inher-ent bias, thus disengaging the fingers from beneath the head of the button. The plunger is therefore now free to be retracted Without withdrawal of the piston, to enable easy removal of the evacuated cartridge and placement within the holder of a filled cartridge.

In a modified form of plunger, a portion of which is shown in section in FlG. 8, the tines, whether there be two or more, need not have a bias imparted thereto to cause divergence of the lingers. Instead, the tines, while resilient, are normally biased to parallel position sand the inner faces of the fingers have a slight bevel 64 imparted thereto so that upon retraction of the plunger after the dosage of medication has been delivered through needle 34, the ngers will be cammed apart to release the button, thus effecting uncoupling or disengagement of the plunger and piston. There is suiicient friction between the piston and tube to accomplish this result when the tines are not confined in the bore of the hub and they are free to spread apart.

Still greater ease in coupling of the cartridge with the plunger of either type described is effected with the modified form of holder described in connection with FIG. 3. 'Ihe holder of FIG. 3 is of a type disclosed in Patent No. 2,956,563 to Stanley I. Sarnoff dated October 18, 1960, to which reference may be made for ampliiication of the disclosure herein. The holder, see FIGS. 3 and 4, comprises a barrel 7b having an end with a bore 72 therein and furcations, here shown as 1bifurcations, to form arms 74 which normally tend to spring apart. The arms have inturned lips 76 at their ends and cams 7 8 on their outer faces, and a ring Stb surrounding the arms is adapted to be slid from over the cams to the right, FIG. 3, to allow the arms to assume their sprung-apart position. The cartridge 12 may now be inserted into the holder by inserting the piston end iirst through the space between the lips '76. The plunger Si), which may be either type previously described, may preliminarily be advanced in the bore, which snugly slidably accommodates the plunger, to a position where it is easy for the tines 42 to be sprung apart and snap over the head t9 of the button 36, if the tines are not normally biased to open position. If the tines are normally biased to open position, the cartridge will move freely until the ange 56 of the button contacts the lingers 48. Further movement of the cartridge to loaded position in the holder will thrust the plunger back to normal initial operative position. ln such operative position the bore 72 will provide a camming action and will hold the fingers on the ends of the tines of the plunger closed on the head `of the button so that the piston may be retracted for aspirating purposes without piston detachment from the plunger. Upon movement of the coupling end of the plunger and piston close to the needle end of the cartridge, the coupling may be detached or become detached, as previously described.

In the case of the form of invention shown in FIG. 3 the plunger can be easily with-drawn Iwithout dragging the piston back with it, and the ring `Sli may then be moved back, -tlius releasing the cartridge for removal from the holder. The holder may now be reloaded, as has already been described.

While particular embodiments of this invention have been illustrated and described, modifications thereof will occur to those skilled in the art. lt is to be understood, therefore, that this invention is not to be limited to the particular arrangements disclosed, and it is intended in the appended claims to cover all modications within the spirit and scope :of this invention.

Having thus described the invention, what is claimed is:

l. A holder comprising a barrel adapted to receive a cartridge with a piston therein,

d a hub, forming part of the holder, provided with a bore therethrough, a plunger snugly slidably reciprocative in said bore, said plunger comprising furcated portions forming a plunger portion slidable in the bore, said furcated portions comprising tines biased to ydiverge rom one another and forced toward one another by movement of the furcated portion in to the bore, and sai-d fui-cated portion terminating in lingers directed to- -ward each other adapted to engage the piston when the fingers are brought close together. 2. A holder comprising a barrel adapted to receive a cartridge with a piston therein,

said piston having a coupling button having a head with an underface of the head perpendicular to the length of the piston, a hub, forming part of the holder, provided with a bore therethrough, e plunger snugly slidably reciprocative in said bore, said plunger comprising a [furcated portion forming a plunger portion slidable in the bore, and said furcated portion terminating in ngers -directed toward each other adapted to engage beneath the head of the button :on the piston, When the fingers are brought together, the face of the fingers adapted to directly engage the underface of the head being bevelled to permit easy disengagement of the plunger from the piston in a predetermined region of the plunger with respect to the barrel. 3. A holder comprising a barrel adapted to receive a cartridge with a piston therein,

said piston having a coupling button having a head with an underface of the head perpendicular to the length of the piston, a hub, forming part of the holder, provided with a bore therethrough, and a plunger snugly slidable in said bore, said plunger comprising an end portion adapted to be engaged by a thumb of an operator, an intermediate solid section, and an end portion, said end portion being furcated lto form tines, said tines being biased to diverge `from one another and forced toward each other by movement of the furcated portion into the bore, said tines having iinger portions formed. on the ends thereof, said linger portions being directed toward each other and adapted to engage the underface of the head of the button yand there being a chamber formed between the lingers to accommodate said head. 4. A holder comprising a barrel adapted to` receive a cartridge with `a piston therein,

said piston having a coupling button having a head with an underface on the head perpendicular to the length of the piston, a huib, forming part of the holder, provided with a bore therethrough, a plunger snugly slidable in said bore, said plunger comprising an end portion adapted to be engaged by .a thumb of an operator, an intermediate solid section, and an end portion, said end portion being furcated to form tines. said tines being biased to diverge from one another and forced toward each other vby movement of the furcated portion into the bore, said tines having finger portions Vformed on the ends thereof, said finger portions -being directed toward each other and adapted to engage the underface of the head of the button and there being a chamber formed between the fingers to accommodate said head, the face of each finger, which is within the chamber,

being bevelled.

5. A holder comprising a barrel adapted to accommodate a cartridge having a piston therein,

said barrel having a hub at one end thereof and having -furcated portions at the other end,

said furcated portions forming arms integral with the hub,

lips at the `free ends of the arms which lips are directed toward each other,

means for drawing the free ends of the arms toward each o er to retain a cartridge within the barrel,

said hub having a lbore therethrough,

a plunger snugly slidably movable in said bore,

said plunger including tines normally biased to diverge from each other and movable through said bore and inturned lingers on the free ends of the tines adapted to `be engaged with the piston when the tines are within the bore.

6. The combination with a barrel having a space receiving a cartridge therein,

said barrel at one end thereof having la hub with a bore therethrough,

a plunger having resilient tines biased to ldiverge away from each other and slidable snugly in said bore whereby the tines when in the bore will lbe urged together and the lbore will resist spreading `action of the tines, the free ends of said tines having fingers directed toward each other,

said cartridge having a hollow needle at one end and ya piston therein at the other end,

a coupling button amxed to the piston,

said button having a head with a face opposed to the lingers whereby when the lingers are engaged with the said face, and the pist-on is near the `hub of the holder, a body fluid may Ibe aspirated into the cartridge via the hollow needle by a retraction of the plunger, pulling the piston with it.

7. The combination with a-barrel having a space receiving a cartridge therein, said barrel having at one end thereof a hub with a bore therethrough,

a plunger having resilient tines biased to diverge away from each other and sl-idable snugly in said bore whereby the tines when in the bore will be urged together Aand the bore will resist spreading action of the tines, the free ends of said tines having fingers directed toward each other,

said cartridge having a hollow needle at one end and a piston therein at the other end,

la coupling button affixed to the piston, said lbutton having -a head with a face thereof perpendicular to the `length of the piston and opposed to the fingers whereby when the fingers :are engaged with the face and the piston is near the hub of the holder, a lbody fluid may be aspirated into the cartridge via the hollow 6 needle by a retraction of the piston, pulling the piston with it. 8. The combination with a Ibarrel having a space receiving a cartridge therein, said barrel having at one end thereof a hub with a bore therethrough,

a plunger having resilient tines biased to diverge away from each other fand slidable snugly in said bore `whereby the tines, ywhen in the bore, will be urged together and the bore will resist spreading action of the tines,

the free ends of said tines having fingers directed toward each other,

lsaid :cartridge having a hollow needle at one end and a piston therein at the other end,

a coupling button affixed to the piston, said button having a head 'with a face `opposed to the fingers perpendicular to the length of the piston, and said fingers having bevelled surfaces to engage said face so that when the piston is near the needle end of the cartridge, the plunger can be cammed away from the head by retraction of the plunger.

9. A holder comprising a barrel 'adapted to accommodate a cartridge having a piston therein,

`said piston having la coupling button having a head with an undersurface on the head perpendicular to the length of the piston,

said barrel having a hub at one end thereof and having furcated portions at the other end,

said furcated portions forming arms integral with the hub,

lips at the tree ends yof the arms which lips are directed toward each other,

means for `drawing the free ends of the arms toward each other to retain a cartridge Within the bar-rel,

said hub having a bore therethrough,

a plunger having tines which tines are snugly slida'ble in `said bore,

`and said tines having inturned fingers on the yfree ends thereof adapted to engage the underface of the head of the button and there being formed a space between the fingers to accommodate the head,

the face yof each finger, which is directed toward the space between the fingers, ybeing bevelled.

References Qited in the file of this patent UNITED STATES PATENTS 1,139,368 Pierce May 11, 1915 1,718,599 Smith June 25, 1929 2,895,773 MicConnaughey July 2'1, 1959 2,915,064 Everett et al. Dec. 1, 1959 2,946,331 lungst July 26, 1960 2,956,563 Sarnoff Oct. 1'8, 1960

Claims (1)

  1. 2. A HOLDER COMPRISING A BARREL ADAPTED TO RECEIVE A CARTRIDGE WITH A PISTON THEREIN, SAID PISTON HAVING A COUPLING BUTTON HAVING A HEAD WITH AN UNDERFACE OF THE HEAD PERPENDICULAR TO THE LENGTH OF THE PISTON, A HUB, FORMING PART OF THE HOLDER, PROVIDED WITH A BORE THERETHROUGH, A PLUNGER SNUGLY SLIDABLY RECIPROCATIVE IN SAID BORE, SAID PLUNGER COMPRISING A FURCATED PORTION FORMING A PLUNGER PORTION SLIDABLE IN THE BORE, AND SAID FURCATED PORTION TERMINATING IN FINGERS DIRECTED TOWARD EACH OTHER ADAPTED TO ENGAGE BENEATH THE HEAD OF THE BUTTON ON THE PISTON, WHEN THE FINGERS ARE BROUGHT TOGETHER, THE FACE OF THE FINGERS ADAPTED TO DIRECTLY ENGAGE THE UNDERFACE OF THE HEAD BEING BEVELLED TO PERMIT EASY DISENGAGEMENT OF THE PLUNGER FROM THE PISTON IN A PREDETERMINED REGION OF THE PLUNGER WITH RESPECT TO THE BARREL.
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US3320955A (en) * 1963-10-09 1967-05-23 Sarnoff Stanley Jay Automatic injection hypodermic syringe
US3348545A (en) * 1964-10-22 1967-10-24 Sarnoff Latched cartridge
US3410267A (en) * 1964-09-18 1968-11-12 Astra Ab Cartridge syringe holder
US4091812A (en) * 1976-01-19 1978-05-30 Alcon Laboratories, Inc. Operator means for syringe cartridges
US4150666A (en) * 1977-06-27 1979-04-24 Sherwood Medical Industries Inc. Tube holder for blood collection tubes of different sizes
DE3001668A1 (en) * 1980-01-18 1981-07-23 Storz Karl Throwaway injection syringe frame - secures plastic syringe in metal tube for higher pressures
US4333456A (en) * 1981-02-09 1982-06-08 Sterling Drug Inc. Self-aspirating hypodermic syringe and self-aspirating assembly therefor
US4333457A (en) * 1981-02-09 1982-06-08 Sterling Drug Inc. Self-aspirating syringe with frictionally engaged locking collet
US4459997A (en) * 1981-11-03 1984-07-17 Walter Sarstedt Kunststoff-Spritzgusswerk Blood extracting and centrifuging device
US4585445A (en) * 1985-08-19 1986-04-29 Sterling Drug Inc. Hypodermic syringe holder for use with disposal ampoules
US4636202A (en) * 1984-07-27 1987-01-13 Syntex (U.S.A.) Inc. Medicament applicator with plunger assembly and automatically-openable closure therefor
US4711250A (en) * 1986-09-09 1987-12-08 Gilbaugh Jr James H Hand-held medical syringe actuator device
WO1989011310A1 (en) * 1988-05-16 1989-11-30 Spinello Ronald P Aspirating hypodermic syringe apparatus and method
US4911695A (en) * 1989-04-03 1990-03-27 Coeur Laboratories, Inc. Plunger for power-driven angiographic syringe, and syringe and power injector system utilizing same
US4990142A (en) * 1989-10-23 1991-02-05 Gte Products Corporation Hypodermic syringe
US5098382A (en) * 1989-12-11 1992-03-24 Habley Medical Technology Corporation Safety module-activator reshielding tool
WO1993019795A1 (en) * 1992-04-06 1993-10-14 L. Molteni & C. Dei F.Lli Alitti S.P.A. Instrument for the injection of pharmaceutical solutions in cartridges
US5451211A (en) * 1991-06-07 1995-09-19 Liebel-Flarsheim Company Disposable front loadable syringe for power injector for injecting fluid into animals
US5531706A (en) * 1991-04-03 1996-07-02 Protecs Syringes International Corporation Safety syringe
US5634909A (en) * 1993-12-09 1997-06-03 Schmitz; William L. Auto-retracting needle injector system
US6077252A (en) * 1997-09-17 2000-06-20 Siegel; Robert Single or multiple dose syringe
US20040108339A1 (en) * 2002-08-29 2004-06-10 Hansen Michael Ejstrup Frontloaded injection device
US20090312717A1 (en) * 2006-07-15 2009-12-17 Asger Voss Christiansen Medical Delivery System with a Rotatable Coding Element
US20110046569A1 (en) * 2009-08-21 2011-02-24 Becton Dickinson France S.A.S. Syringe Having a Collapsible Plunger Rod
US20110046566A1 (en) * 2006-11-21 2011-02-24 Novo Nordisk A/S Medical Delivery System Comprising Locking Ring with L-Shaped Grooves
US20110092917A1 (en) * 2008-05-05 2011-04-21 Becton, Dickinson And Company Drug delivery device having cartridge with enlarged distal end
US8197450B2 (en) 2005-04-24 2012-06-12 Novo Nordisk A/S Injection device
US8202256B2 (en) 2000-06-16 2012-06-19 Novo Nordisk A/S Injection device
US8226618B2 (en) 2006-05-16 2012-07-24 Novo Nordisk A/S Gearing mechanism for an injection device
EP2502643A1 (en) * 2011-03-22 2012-09-26 Sanofi-Aventis Deutschland GmbH Drug delivery device with pack size reduction
US8298194B2 (en) 2006-03-10 2012-10-30 Novo Nordisk A/S Injection device and a method of changing a cartridge in the device
US8353878B2 (en) 2007-03-23 2013-01-15 Novo Nordisk A/S Injection device comprising a locking nut
US8361036B2 (en) 2006-03-10 2013-01-29 Novo Nordisk A/S Injection device having a gearing arrangement
US20130066279A1 (en) * 2010-03-31 2013-03-14 Sanofi-Aventis Deutschland Gmbh Piston rod assembly for a drug delivery device
US20130085453A1 (en) * 2011-09-30 2013-04-04 Becton Dickinson France, S.A.S. Syringe Having a Squeeze-Fit Plunger Rod
US20140358093A1 (en) * 2012-01-25 2014-12-04 Novo Nordisk A/S Drug Delivery Device with Cartridge Fixation Feature
US9173995B1 (en) 2014-10-28 2015-11-03 Bayer Healthcare Llc Self-orienting syringe and syringe interface
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
US9199033B1 (en) 2014-10-28 2015-12-01 Bayer Healthcare Llc Self-orienting syringe and syringe interface
US9333288B2 (en) 2011-09-30 2016-05-10 Becton Dickinson France, S.A.S. Attachable plunger rod and associated packaging
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen

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US3348545A (en) * 1964-10-22 1967-10-24 Sarnoff Latched cartridge
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US4150666A (en) * 1977-06-27 1979-04-24 Sherwood Medical Industries Inc. Tube holder for blood collection tubes of different sizes
DE3001668A1 (en) * 1980-01-18 1981-07-23 Storz Karl Throwaway injection syringe frame - secures plastic syringe in metal tube for higher pressures
US4333456A (en) * 1981-02-09 1982-06-08 Sterling Drug Inc. Self-aspirating hypodermic syringe and self-aspirating assembly therefor
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US4459997A (en) * 1981-11-03 1984-07-17 Walter Sarstedt Kunststoff-Spritzgusswerk Blood extracting and centrifuging device
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US5456669A (en) * 1991-06-07 1995-10-10 Liebel-Flarsheim Company Method of front loading an injector and injecting fluid into animals therewith
US5456670A (en) * 1991-06-07 1995-10-10 Liebel-Flarsheim Company Power injector for injecting fluid into animals
US5451211A (en) * 1991-06-07 1995-09-19 Liebel-Flarsheim Company Disposable front loadable syringe for power injector for injecting fluid into animals
US6659979B2 (en) 1991-06-07 2003-12-09 Liebel Flarsheim Company Method of injecting fluid into animals
US5738659A (en) * 1991-06-07 1998-04-14 Liebel-Flarsheim Company Method of injecting fluid into animals
US20060264744A1 (en) * 1991-06-07 2006-11-23 Liebel-Flarsheim Company Method and Apparatus for Injecting Fluid into Animals and Disposable Front Loadable Syringe Therefor
US20040122371A1 (en) * 1991-06-07 2004-06-24 Liebel-Flarsheim Company Method and apparatus for injecting fluid into animals and disposable front loadable syringe therefor
WO1993019795A1 (en) * 1992-04-06 1993-10-14 L. Molteni & C. Dei F.Lli Alitti S.P.A. Instrument for the injection of pharmaceutical solutions in cartridges
US5634909A (en) * 1993-12-09 1997-06-03 Schmitz; William L. Auto-retracting needle injector system
US6077252A (en) * 1997-09-17 2000-06-20 Siegel; Robert Single or multiple dose syringe
US8267899B2 (en) 2000-06-16 2012-09-18 Novo Nordisk A/S Injection device
US9022991B2 (en) 2000-06-16 2015-05-05 Novo Nordisk A/S Injection device
US8206361B2 (en) 2000-06-16 2012-06-26 Novo Nordisk A/S Injection device
US8333739B2 (en) 2000-06-16 2012-12-18 Novo Nordisk A/S Injection device
US8202256B2 (en) 2000-06-16 2012-06-19 Novo Nordisk A/S Injection device
US7175055B2 (en) 2002-08-29 2007-02-13 Novo Nordisk, A/S Frontloaded injection device
US20040108339A1 (en) * 2002-08-29 2004-06-10 Hansen Michael Ejstrup Frontloaded injection device
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US8197450B2 (en) 2005-04-24 2012-06-12 Novo Nordisk A/S Injection device
US8641683B2 (en) 2005-04-24 2014-02-04 Novo Nordisk A/S Injection device
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US8298194B2 (en) 2006-03-10 2012-10-30 Novo Nordisk A/S Injection device and a method of changing a cartridge in the device
US8900204B2 (en) 2006-05-16 2014-12-02 Novo Nordisk A/S Gearing mechanism for an injection device
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US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
US9050397B2 (en) 2006-07-15 2015-06-09 Novo Nordisk A/S Medical delivery system with a rotatable coding element
US20090312717A1 (en) * 2006-07-15 2009-12-17 Asger Voss Christiansen Medical Delivery System with a Rotatable Coding Element
US8708972B2 (en) 2006-07-15 2014-04-29 Novo Nordisk A/S Medical delivery system with a rotatable coding element
US9289558B2 (en) 2006-11-21 2016-03-22 Novo Nordisk A/S Medical delivery system comprising locking ring with L-shaped grooves
US8672897B2 (en) 2006-11-21 2014-03-18 Novo Nordisk A/S Medical delivery system comprising locking ring with L-shaped grooves
US20110046566A1 (en) * 2006-11-21 2011-02-24 Novo Nordisk A/S Medical Delivery System Comprising Locking Ring with L-Shaped Grooves
US8353878B2 (en) 2007-03-23 2013-01-15 Novo Nordisk A/S Injection device comprising a locking nut
US20110092917A1 (en) * 2008-05-05 2011-04-21 Becton, Dickinson And Company Drug delivery device having cartridge with enlarged distal end
US8632519B2 (en) * 2009-08-21 2014-01-21 Becton Dickinson France, S.A.S. Syringe having a collapsible plunger rod
WO2011022615A1 (en) * 2009-08-21 2011-02-24 Becton Dickinson France Sas Syringe having a collapsible plunger rod
US9295783B2 (en) 2009-08-21 2016-03-29 Becton Dickinson France Syringe having a collapsible plunger rod
US20110046569A1 (en) * 2009-08-21 2011-02-24 Becton Dickinson France S.A.S. Syringe Having a Collapsible Plunger Rod
US20130066279A1 (en) * 2010-03-31 2013-03-14 Sanofi-Aventis Deutschland Gmbh Piston rod assembly for a drug delivery device
US9084852B2 (en) * 2010-03-31 2015-07-21 Sanofi-Aventis Deutschland Gmbh Piston rod assembly for a drug delivery device
EP2502643A1 (en) * 2011-03-22 2012-09-26 Sanofi-Aventis Deutschland GmbH Drug delivery device with pack size reduction
US9333288B2 (en) 2011-09-30 2016-05-10 Becton Dickinson France, S.A.S. Attachable plunger rod and associated packaging
US9119919B2 (en) * 2011-09-30 2015-09-01 Becton Dickinson France, S.A.S. Syringe having a squeeze-fit plunger rod
US20130085453A1 (en) * 2011-09-30 2013-04-04 Becton Dickinson France, S.A.S. Syringe Having a Squeeze-Fit Plunger Rod
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
US20140358093A1 (en) * 2012-01-25 2014-12-04 Novo Nordisk A/S Drug Delivery Device with Cartridge Fixation Feature
US9700670B2 (en) 2014-10-28 2017-07-11 Bayer Healthcare Llc Self-orienting syringe and syringe interface
US9199033B1 (en) 2014-10-28 2015-12-01 Bayer Healthcare Llc Self-orienting syringe and syringe interface
US9173995B1 (en) 2014-10-28 2015-11-03 Bayer Healthcare Llc Self-orienting syringe and syringe interface

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