US2850007A - Biopsy device - Google Patents

Biopsy device Download PDF

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Publication number
US2850007A
US2850007A US58852856A US2850007A US 2850007 A US2850007 A US 2850007A US 58852856 A US58852856 A US 58852856A US 2850007 A US2850007 A US 2850007A
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Prior art keywords
tissue
end
hub
member
needle
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Expired - Lifetime
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Robert C Lingley
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Wyeth Holdings LLC
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Wyeth Holdings LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/0233Pointed or sharp biopsy instruments
    • A61B10/0266Pointed or sharp biopsy instruments means for severing sample
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00681Aspects not otherwise provided for
    • A61B2017/00685Archimedes screw

Description

Sept. 2, 1958 R. c. LINGLEY BIOPSY DEVICE Filed May 51, 1956 \llllllllllllllllllllll llllllllllllllllllll m /70 4. 1 s v. o a

ATTORNEY.

BIOPSY DEVICE Robert C. 'Lingley, Waltham, Mass assignor to American Cyanamid Company, New York, N. Y., a corporation of Maine Application May 31, 1956, Serial No. 588,528

11 Claims. (Cl. 128-2) The present invention relates to biopsy instruments and to the parts thereof.

For a biopsy, it is necessary to secure enough tissue from the suspected area to meet the requirements of the examination. Where that area is located at a depth, it is often difiicult to secure tissue from it, at least in adequate supply, and the principal objective of this invention is to furnish an instrument enabling tissue, whether hard or soft, to be effectively sampled even at substantial depths.

This generally stated objective is attained, in accordance With the invention, with a biopsy instrument comprising a needle consisting of a cannula having one end adapted for entry into the tissue and a hub attached to its other end. A member is slidable and rotatable in the needle and has a tissue cutting portion at one end in the form of a helix and a portion at its other end which has a screw feed part detachably engageable with a complemental part on the needle hub.

With such a device, when the needle is advanced into tissue in the suspected area independently of its member, it receives and partially severs a mass of tissue. With the screw feed parts engaged, the member is then rotated to advance positively its helical cutting portion into the contained mass to the desired extent to cut it into a spirally disposed specimen of such small cross sectional dimensions that rupture proximate the extremity of the helical cutting portion is ensured when the needle and member are Withdrawn as a unit. It is thus assured that the retained specimen will furnish an adequate supply of tissue for biopsy purposes.

In the accompanying drawings, there is shown an illustrative embodiment of the invention from which these and other of its objectives, novel features, and advantages will be readily appreciated.

In the drawings:

Fig. 1 is a view of a biopsy instrument, showing, in

,plan view, the screw feed part with which the needle .is provided and with an obturator in place,

Fig. 2 is a fragmentary view thereof with said part partly broken away,

Fig. 3 is a view of the obturator,

Fig. 4 is a longitudinal section of the needle inserted in tissue with the obturator blocking the cannula bore,

Fig. 5 is a similar .view with the needle advanced relative to the obturator to receive Within it tissue .from a suspected area, .and

Fig. 6 illustrates the advance of a helical cutting member in accordance with the invention into the contained mass of tissue.

At 10, there is generally indicated a needle, shown as having its cannula 11 beveled at one end as at 12 to provide a tissue piercing point and having at its other end a hub 13 provided with a bore 14 with which the bore of the cannula 11 is in axial communication.

A generally indicated obturator 15, see Fig. 3, has its stem 16 dimensioned to be a close fit in the cannula 11 but to be slidable and rotatable with respect thereto.

Patented Sept. 2, 1958 "Ice The obturator is conventional and is of sufficient length sothat its beveled end 17 will lie flush with the cannula "tissue within it. The needle 10 is then advanced into the suspected area to receive within it a plugor mass of tissue that must be severed. Usually before such advance, a tissue retaining member, generally indicated at 22, is inserted into the needle 10 in substitution of the obturator 15.

In order that such received tissue will remain in the needle 10 as it is withdrawn, the tissue retaining member 22 is shown as having a helical portion 23 at one end and a portion 24 at its other end dimensioned to enter the hub bore 14, and including a finger grip 25. The helical cutting portion 23 is shown as a spiral diinensio-ned to be a close fit in the needle 10 and as having its free extremity in the form of a transversely disposed cutting edge 26.

As illustrative of complemental screw feed parts by which the tissue retaining member 22 may be positively advanced to a determined extent, the portion 24 of the tissue retaining member 22 is shown as having threads 27 and these may he engaged by the part 28 with which the resilient arm 25%, attached to the hub 13, is provided and which normally holds said screw feed parts disengaged. When, however, the arm 29 is manually depressed to effect the engagement of the parts, the tissue retaining member 22 may be rotated to positively advance its cutting portion 23 relative to the needle 10 into the mass of contained tissue to cut that mass into a spirally dispose-d specimen of cross sectional dimension that will rupture readily adjacent the extremity of the helical cutting portion when the device is withdrawn. In practice, the pitch of the threads 27 is the same as that of the helical cutting portion 23.

In order that the parts may be detachably locked together, the hub 13 is shown as having a. longitudinally disposed T-shaped channel 30 adapted to receive the head 31 of a slide 32 carried by. the arm 29 in a slot 33.

From the foregoing, it will be apparent that biopsy devices, in accordance with the invention, are well adapted to meet the important requirements of ensuring the positive removal of a specimen tissue, either hard or soft, from suspected internal areas, that will prove adequate for examination purposes.

What I therefore claim and desire to secure by 'Letters Patent is:

1. A biopsy device comprising a needle including ;a

hub and cannula-having one end pointed for entry into tissue and the other end attached'to said .hub, and a member slidable and rotatable'in said cannula and'hub and including a helical cutting-portion at one end and a-second portion at the other end, said'hub and said second'portion including'complemental, disengageable, screw ='feed parts,

2. A biopsy device comprising a needle including a hub and cannula having one end pointed for entry into tissue and the other end attached to said hub, and a member slidable and rotatable in said cannula and hub and including a helical cutting portion at one end and a second portion at the other end, said hub and said second portion including complemental, disengageable, screw feed parts, said needle, when advanced into tissue independently of said needle and said member being movable relative to one another so that either may be first advanced into tissue and the other then advanced with respect thereto, said screw feed parts, when engaged, ensuring that on rotation of said member, its advance is positive, the combined action of the advancement of said needle and member being that of effecting the cutting of a mass of tissue into a spiral specimen whose cross seeitonal dimension ensures rupture of the retained specimen proximate to the extremity of the helical cutting portion when said device is withdrawn, the pitch of the helical cutting portion being the same as that established by said screw feed parts.

3. A biopsy device comprising a needle including a hub and a cannula having one end pointed for entry into tissue and the other end attached to said hub and a member slidable and rotatable in said cannula and hub and including a helical cutting portion at one end and a second portion at the other end, said hub and said second portion including complemental screw feed parts, the screw feed part carried by said hub including a resilient supporting arm normally holding it from an operative position with respect to the screw feed part of the member, said needle and said member being movable relative to one another so that either may be first advanced into tissue and the other then advanced with respect thereto, said screw feed parts, when engaged, ensuring that on rotation of said member, its advance is positive, the combined action of the advancement of said needle and member being that of effecting the cutting of a mass of tissue into a spirally disposed specimen whose cross sectional dimensions ensure rupture of the retained specimen proximate to the extremity of the helical cutting portion when said device is withdrawn.

4. A biopsy device comprising a needle including a hub and a cannula having one end pointed for entry into tissue and the other end attached to said hub and a member slidable and rotatable in said cannula and hub and including a helical cutting portion at one end and a second portion at the other end, said hub and said second portion including complemental screw feed parts, the screw feed part carried by said hub including a resilient supporting arm normally holding it from an operative position with respect to the screw feed part of the member and means on said hub engageable with said arm to lock said hub part in said operative position, said needle and said member being movable relative to one another so that either may be first advanced into tissue and the other then advanced with respect thereto, said screw feed parts, when engaged, ensuring that on rotation of said member, its advance is positive, the combined action of the advancement of said needle and member being that of effecting the cutting of a mass of tissue into a spirally disposed specimen whose cross sectional dimensions ensure rupture of the retained specimen proximate the end of the retained helical cutting portion when said device is withdrawn.

5. A biopsy device comprising a needle including a hub and a cannula having one end pointed for entry into tissue and the other end attached to said hub and a member slidable and rotatable in said cannula and hub and including a helical cutting portion at one end and a threaded portion at the other end, a thread engaging part carried by said hub for movement into and out of engagement with the said threaded portion to establish a connection, said needle and said member being movable relative to one another so that either may be first advanced into tissue and the other then advanced with respect thereto, said screw feed parts, when engaged, ensuring that on rotation of said member, its advance is positive, the combined action of the advancement of said needle and member being that of effecting the cutting of a mass of tissue into a spirally disposed specimen whose cross sectional dimensions ensure rupture of the retained specimen proximate the end of the cutting portion when said device is withdrawn.

6. A biopsy needle for use with a tissue severing member provided at one end with one part of a screw feed, said needle comprising a cannula having one end for entry into tissue and a hub on the other end of said cannula, said hub and said cannula slidably and rotatably receiving said member, and a eomplemental screw feed part carried by said hub for engagement with the member part thereof.

7. A biopsy needle for use with a tissue severing member provided at one end with a threaded portion, said needle comprising a cannula having one end for entry into tissue, and a hub on the other end of said cannula, said hub and said cannula slidably and rotatably receiving said member, a resilient arm on said hub, and a part carried by said arm for engagement with said threaded portion.

8. A biopsy needle for use with a tissue severing member provided at one end with a threaded portion, said needle comprising a cannula having one end for entry into tissue and a hub on the other end of said cannula, said hub and said cannula slidably and rotatably receiving said member, a resilient arm on said hub, and a part carried by said arm for engagement with said threaded portion and means for detachably locking said arm in engagement.

9. A tissue severing member to be slidably and r0 tatably received within a biopsy needle whose hub has a screw feed part, said member including at one end a helical tissue entering portion and at the other end a complemental screw feed part.

10. A tissue severing member to be slidably and rotatably received within a biopsy needle whose hub has a screw feed part, said member including at one end a helical tissue entering portion and at the other end a threaded part.

11. A tissue severing member to be slidably and rotatably received within a biopsy needle whose hub has a screw feed part, said member including at one end a helix whose free end has a transverse cutting edge and the other end has a complemental screw feed part.

References Cited in the file of this patent UNITED STATES PATENTS

US2850007A 1956-05-31 1956-05-31 Biopsy device Expired - Lifetime US2850007A (en)

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Cited By (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3007471A (en) * 1959-04-27 1961-11-07 Jr John N Mcclure Biopsy instrument
US3330268A (en) * 1963-12-18 1967-07-11 Goldsmith Sidney Biopsy needle
US3585986A (en) * 1969-08-21 1971-06-22 Becton Dickinson Co Stylet
US3628524A (en) * 1969-02-28 1971-12-21 Khosrow Jamshidi Biopsy needle
US3683891A (en) * 1970-06-26 1972-08-15 Marshall Eskridge Tissue auger
US3709211A (en) * 1970-07-02 1973-01-09 F Hawkins Diagnostic myelography needle
US3884220A (en) * 1972-07-05 1975-05-20 Leo J Hartnett Method for injecting X-ray contrast media for venography of the female pelvis
US3945372A (en) * 1973-06-01 1976-03-23 Milan Albert R Medical tissue-obtaining system
US4002169A (en) * 1972-04-18 1977-01-11 Cupler Ii John A Method and apparatus for performing surgery without tissue incision
US4010737A (en) * 1971-06-14 1977-03-08 Vilaghy Miklos I Bone biopsy instrument kit
FR2350821A1 (en) * 1976-05-10 1977-12-09 Baylis Shelby Biopsy sample cutting device - has outer tube with mandrel replaceable by inner tube with internal cutting edge
US4177797A (en) * 1977-03-04 1979-12-11 Shelby M. Baylis Rotary biopsy device and method of using same
US4230123A (en) * 1978-10-31 1980-10-28 Hawkins Jr Irvin F Needle sheath complex and process for decompression and biopsy
US4262676A (en) * 1979-08-24 1981-04-21 Khosrow Jamshidi Biopsy needle having integral stylet locking device
US4266555A (en) * 1979-11-09 1981-05-12 Khosrow Jamshidi Biopsy needle with stylet and cannula orientation
WO1982003167A1 (en) * 1981-03-16 1982-09-30 Donald N Mehl Biopsy needle
US4378810A (en) * 1981-03-26 1983-04-05 The Regents Of The University Of California Assembly for performing biopsies using a combination probe-guide
EP0097706A1 (en) * 1981-12-24 1984-01-11 Creative Research And Manufacturing Inc. Bone marrow aspiration needle
US4487209A (en) * 1981-03-16 1984-12-11 Creative Research And Manufacturing Inc. Biopsy needle
US4512344A (en) * 1982-05-12 1985-04-23 Barber Forest C Arthroscopic surgery dissecting apparatus
US4530356A (en) * 1983-02-08 1985-07-23 Helfgott Maxwell A Ophthalmic surgical instrument with beveled tip
US4573448A (en) * 1983-10-05 1986-03-04 Pilling Co. Method for decompressing herniated intervertebral discs
US4653496A (en) * 1985-02-01 1987-03-31 Bundy Mark A Transluminal lysing system
US4785826A (en) * 1987-03-02 1988-11-22 Ward John L Biopsy instrument
US4919146A (en) * 1988-10-25 1990-04-24 Medrad, Inc. Biopsy device
WO1990015576A1 (en) * 1989-06-15 1990-12-27 Research Corporation Technologies, Inc. Lesion localization device and method of using
US5078723A (en) * 1989-05-08 1992-01-07 Medtronic, Inc. Atherectomy device
US5279306A (en) * 1981-03-16 1994-01-18 Creative Research And Manufacturing Biopsy needle
US5423799A (en) * 1988-12-14 1995-06-13 Medtronic, Inc. Surgical instrument
US5425376A (en) * 1993-09-08 1995-06-20 Sofamor Danek Properties, Inc. Method and apparatus for obtaining a biopsy sample
US5488958A (en) * 1992-11-09 1996-02-06 Vance Products Incorporated Surgical cutting instrument for coring tissue affixed thereto
US5542432A (en) * 1992-02-18 1996-08-06 Symbiosis Corporation Endoscopic multiple sample bioptome
US5779647A (en) * 1995-06-07 1998-07-14 Chau; Sonny Automated biopsy instruments
US5810744A (en) * 1993-05-17 1998-09-22 Boston Scientific Corporation Instrument for collecting multiple biopsy specimens
US5871453A (en) * 1994-02-08 1999-02-16 Boston Scientific Corporation Moveable sample tube multiple biopsy sampling device
US5893862A (en) * 1997-04-10 1999-04-13 Pratt; Arthur William Surgical apparatus
US6001112A (en) * 1998-04-10 1999-12-14 Endicor Medical, Inc. Rotational atherectomy device
EP0992218A1 (en) * 1998-10-09 2000-04-12 Gallini S.R.L Biopsy device
US6142957A (en) * 1993-09-20 2000-11-07 Boston Scientific Corporation Multiple biopsy sampling device
US6193671B1 (en) 1994-02-01 2001-02-27 Symbiosis Corporation Endoscopic multiple sample bioptome with enhanced biting action
US6451036B1 (en) 1998-04-10 2002-09-17 Endicor Medical, Inc. Rotational atherectomy system with stationary cutting elements
US6468228B1 (en) * 1996-06-18 2002-10-22 Vance Products Incorporated Surgical tissue morcellator
US6482217B1 (en) 1998-04-10 2002-11-19 Endicor Medical, Inc. Neuro thrombectomy catheter
US20030114773A1 (en) * 2001-02-16 2003-06-19 Janssens Jacques Phillibert Device for taking a tissue sample
US6814743B2 (en) 2001-12-26 2004-11-09 Origin Medsystems, Inc. Temporary seal and method for facilitating anastomosis
US20040249278A1 (en) * 2003-06-04 2004-12-09 Krause William R. Biopsy and delivery device
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GB2384188B (en) * 2001-12-06 2005-04-27 Hiromi Matsuzaki Surgical instruments and a set of surgical instruments for use in treatment of vertebral bodies
US6979328B2 (en) 2001-01-18 2005-12-27 The Regents Of The University Of California Minimally invasive glaucoma surgical instrument and method
US20070010840A1 (en) * 2003-04-22 2007-01-11 Fox Hollow Technologies, Inc. Methods and devices for cutting tissue at a vascular location
US20070073326A1 (en) * 2005-09-26 2007-03-29 Miller Michael E Rotating surgical cutter
US20070276419A1 (en) * 2006-05-26 2007-11-29 Fox Hollow Technologies, Inc. Methods and devices for rotating an active element and an energy emitter on a catheter
WO2009079155A2 (en) * 2007-11-20 2009-06-25 The Cleveland Clinic Foundation Method and apparatus for tissue sampling
US20090299394A1 (en) * 1999-08-19 2009-12-03 Fox Hollow Technologies, Inc. Methods and devices for cutting tissue
US20100069843A1 (en) * 2008-09-15 2010-03-18 Biomet Biologics Drive Bone marrow aspiration needle
US20100130996A1 (en) * 2008-10-13 2010-05-27 Fox Hollow Technologies, Inc. Devices and methods for manipulating a catheter shaft
US20100198240A1 (en) * 2000-12-20 2010-08-05 Fox Hollow Technologies, Inc. Debulking catheters and methods
US20100292721A1 (en) * 2009-05-14 2010-11-18 Fox Hollow Technologies, Inc. Easily cleaned atherectomy catheters and methods of use
US20100298850A1 (en) * 1999-08-19 2010-11-25 Fox Hollow Technologies, Inc. Atherectomy catheter with aligned imager
US20110130777A1 (en) * 2009-12-02 2011-06-02 Fox Hollow Technologies, Inc. Methods and devices for cutting tissue
US20110144673A1 (en) * 2009-12-11 2011-06-16 Fox Hollow Technologies, Inc. Material removal device having improved material capture efficiency and methods of use
US8328829B2 (en) 1999-08-19 2012-12-11 Covidien Lp High capacity debulking catheter with razor edge cutting window
US8469979B2 (en) 2000-12-20 2013-06-25 Covidien Lp High capacity debulking catheter with distal driven cutting wheel
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US20130338570A1 (en) * 2005-05-09 2013-12-19 Boston Scientific Scimed, Inc. Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent
US8784440B2 (en) 2008-02-25 2014-07-22 Covidien Lp Methods and devices for cutting tissue
US8808186B2 (en) 2010-11-11 2014-08-19 Covidien Lp Flexible debulking catheters with imaging and methods of use and manufacture
US20140276578A1 (en) * 2013-03-12 2014-09-18 Magnolia Medical Technologies, Inc. Methods and apparatus for selectively occluding the lumen of a needle
US8920450B2 (en) 2010-10-28 2014-12-30 Covidien Lp Material removal device and method of use
US8992717B2 (en) 2011-09-01 2015-03-31 Covidien Lp Catheter with helical drive shaft and methods of manufacture
RU2551957C1 (en) * 2014-05-05 2015-06-10 Евгений Михайлович Трунин Thyroid tissue sampling device
US9119662B2 (en) 2010-06-14 2015-09-01 Covidien Lp Material removal device and method of use
US9301735B2 (en) 2012-12-19 2016-04-05 Cook Medical Technologies Llc Drive system for a biopsy member
US9347533B2 (en) 2012-07-25 2016-05-24 Cook Medical Technologies Llc Rotational drive system for a biopsy member
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US9532844B2 (en) 2012-09-13 2017-01-03 Covidien Lp Cleaning device for medical instrument and method of use
US9597110B2 (en) 2012-11-08 2017-03-21 Covidien Lp Tissue-removing catheter including operational control mechanism
US9687266B2 (en) 2009-04-29 2017-06-27 Covidien Lp Methods and devices for cutting and abrading tissue
US9943329B2 (en) 2012-11-08 2018-04-17 Covidien Lp Tissue-removing catheter with rotatable cutter

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Cited By (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3007471A (en) * 1959-04-27 1961-11-07 Jr John N Mcclure Biopsy instrument
US3330268A (en) * 1963-12-18 1967-07-11 Goldsmith Sidney Biopsy needle
US3628524A (en) * 1969-02-28 1971-12-21 Khosrow Jamshidi Biopsy needle
US3585986A (en) * 1969-08-21 1971-06-22 Becton Dickinson Co Stylet
US3683891A (en) * 1970-06-26 1972-08-15 Marshall Eskridge Tissue auger
US3709211A (en) * 1970-07-02 1973-01-09 F Hawkins Diagnostic myelography needle
US4010737A (en) * 1971-06-14 1977-03-08 Vilaghy Miklos I Bone biopsy instrument kit
US4002169A (en) * 1972-04-18 1977-01-11 Cupler Ii John A Method and apparatus for performing surgery without tissue incision
US3884220A (en) * 1972-07-05 1975-05-20 Leo J Hartnett Method for injecting X-ray contrast media for venography of the female pelvis
US3945372A (en) * 1973-06-01 1976-03-23 Milan Albert R Medical tissue-obtaining system
FR2350821A1 (en) * 1976-05-10 1977-12-09 Baylis Shelby Biopsy sample cutting device - has outer tube with mandrel replaceable by inner tube with internal cutting edge
US4177797A (en) * 1977-03-04 1979-12-11 Shelby M. Baylis Rotary biopsy device and method of using same
US4230123A (en) * 1978-10-31 1980-10-28 Hawkins Jr Irvin F Needle sheath complex and process for decompression and biopsy
US4262676A (en) * 1979-08-24 1981-04-21 Khosrow Jamshidi Biopsy needle having integral stylet locking device
US4266555A (en) * 1979-11-09 1981-05-12 Khosrow Jamshidi Biopsy needle with stylet and cannula orientation
US5279306A (en) * 1981-03-16 1994-01-18 Creative Research And Manufacturing Biopsy needle
WO1982003167A1 (en) * 1981-03-16 1982-09-30 Donald N Mehl Biopsy needle
US4487209A (en) * 1981-03-16 1984-12-11 Creative Research And Manufacturing Inc. Biopsy needle
US4378810A (en) * 1981-03-26 1983-04-05 The Regents Of The University Of California Assembly for performing biopsies using a combination probe-guide
EP0097706A1 (en) * 1981-12-24 1984-01-11 Creative Research And Manufacturing Inc. Bone marrow aspiration needle
EP0097706A4 (en) * 1981-12-24 1985-07-01 Creative Res And Mfg Inc Bone marrow aspiration needle.
US4512344A (en) * 1982-05-12 1985-04-23 Barber Forest C Arthroscopic surgery dissecting apparatus
US4530356A (en) * 1983-02-08 1985-07-23 Helfgott Maxwell A Ophthalmic surgical instrument with beveled tip
US4573448A (en) * 1983-10-05 1986-03-04 Pilling Co. Method for decompressing herniated intervertebral discs
US4653496A (en) * 1985-02-01 1987-03-31 Bundy Mark A Transluminal lysing system
US4785826A (en) * 1987-03-02 1988-11-22 Ward John L Biopsy instrument
US4919146A (en) * 1988-10-25 1990-04-24 Medrad, Inc. Biopsy device
US5423799A (en) * 1988-12-14 1995-06-13 Medtronic, Inc. Surgical instrument
US6443966B1 (en) 1988-12-14 2002-09-03 Intravascular Medical, Inc. Surgical instrument
US5078723A (en) * 1989-05-08 1992-01-07 Medtronic, Inc. Atherectomy device
US5018530A (en) * 1989-06-15 1991-05-28 Research Corporation Technologies, Inc. Helical-tipped lesion localization needle device and method of using the same
EP0477303A4 (en) * 1989-06-15 1992-05-27 Research Corporation Technologies, Inc. Lesion localization device and method of using
WO1990015576A1 (en) * 1989-06-15 1990-12-27 Research Corporation Technologies, Inc. Lesion localization device and method of using
EP0477303A1 (en) * 1989-06-15 1992-04-01 Research Corporation Technologies, Inc. Lesion localization device
US5951488A (en) * 1992-02-18 1999-09-14 Symbiosis Corporation Endoscopic multiple sample bioptome
US5542432A (en) * 1992-02-18 1996-08-06 Symbiosis Corporation Endoscopic multiple sample bioptome
US5488958A (en) * 1992-11-09 1996-02-06 Vance Products Incorporated Surgical cutting instrument for coring tissue affixed thereto
US5810744A (en) * 1993-05-17 1998-09-22 Boston Scientific Corporation Instrument for collecting multiple biopsy specimens
US5425376A (en) * 1993-09-08 1995-06-20 Sofamor Danek Properties, Inc. Method and apparatus for obtaining a biopsy sample
US6142957A (en) * 1993-09-20 2000-11-07 Boston Scientific Corporation Multiple biopsy sampling device
US6561988B1 (en) 1994-02-01 2003-05-13 Symbiosis Corporation Endoscopic multiple sample bioptome with enhanced biting action
US6193671B1 (en) 1994-02-01 2001-02-27 Symbiosis Corporation Endoscopic multiple sample bioptome with enhanced biting action
US6053877A (en) * 1994-02-08 2000-04-25 Boston Scientific Corporation Movable sample tube multiple biopsy sampling device
US5871453A (en) * 1994-02-08 1999-02-16 Boston Scientific Corporation Moveable sample tube multiple biopsy sampling device
US5779647A (en) * 1995-06-07 1998-07-14 Chau; Sonny Automated biopsy instruments
US6626850B1 (en) 1995-06-07 2003-09-30 Allegiance Corporation Automated biopsy instruments
US6468228B1 (en) * 1996-06-18 2002-10-22 Vance Products Incorporated Surgical tissue morcellator
US5893862A (en) * 1997-04-10 1999-04-13 Pratt; Arthur William Surgical apparatus
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