US2828743A - Snap-on cartridge-needle unit - Google Patents

Snap-on cartridge-needle unit Download PDF

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Publication number
US2828743A
US2828743A US66592957A US2828743A US 2828743 A US2828743 A US 2828743A US 66592957 A US66592957 A US 66592957A US 2828743 A US2828743 A US 2828743A
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Grant
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Prior art keywords
needle
cartridge
hub
ferrule
end
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Inventor
David M Ashkenaz
Marston L Hamlin
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Wyeth LLC
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Wyeth LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515Connection of piston with piston rod
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/348Constructions for connecting the needle, e.g. to syringe nozzle or needle hub snap lock, i.e. upon axial displacement of needle assembly
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202Devices for protection of the needle before use, e.g. caps

Description

April 1, 1958 D. M. AsHKENAz ETAL SNAP-0N CARTRIDGE-NEEDLE UNIT Filed June 17, 195'? ATTORNEY United States Patent() SNAP-ON CARTRIDGE-NEEDLE UNIT David M. Ashkenaz, Bala Cynwyd, Pa., and Marston L. Hamlin, Lynbroolr, N. Y., assignors to American Home Products Corporation, New York, N. Y., a corporation of Delaware Application June 17, 1957, Serial No. 665,929

7 Claims. (Cl. 12S-41E) ment simultaneously causes the needle to penetrate the closure and seats the needle firmly in a ferrule secured to the cartridge.

Various tonus of cartridge-needle units have been proposed in which anv injection needle is brought into communication with the interior of the cartridge by a simple relative linear movement. In these units needle hubs and cartridge ferrules of both metal and plastic have been proposed. All of these, as far as we know and in contrast to those units which comprise a screw-threaded connection, suier from the disadvantage of an insulliciently secure seat for the needle when in communication with the interior of the cartridge.

It is an object of the present invention to provide a cartridge-needle unit of the kind described in which a simple longitudinal movement of the needle simultaneously causes it to penetrate the cartridge closure and seats it firmly on the cartridge without wobble.

It is a further object to provide such a unit having a needle fixedly mounted in a hub provided with an external skirt surrounding a cartridge ferrule and an internal male cone mating with a tapered female recess in a cartridge ferrule.

It is an additional object to provide such a unit in which the needle hub may be fabricated of synthetic plastic.

Other objects and advantages of our invention will be apparent from the following description which, with the drawing, is intended to be illustrative only and not to limit our invention, the scope of which is defined in the appended claims.

In the drawing:

Fig. 1 is va longitudinal section of a cartridge-needle unit according to one embodiment of our invention;

Fig. 2 is an enlarged section of a portion of a slightly modified form of the invention;

Fig. 3 shows our unit in place in a syringe body;

Fig. 4 illustrates our invention, partly in section, applied to a disposable syringe; and

Fig. 5 is a perspective view, partly in section, of a modified form of needle hub according to our invention.

In the drawing a tube 1 containing an injectable drug 2 is closed at its proximal end by a slideable plunger 3 provided with a threaded stud 4 adapted to engage a push rod 5 having a thumb piece 6. The distal end of tube 1 is closed by a penetrable closure which may be a at disc 7 or a flanged stopper 8. The closure is seated on and compressed against tube ange 9 by means of a crimped skirt 10 integral with ferrule 11. Alternatively the crimp- 2,828,743 Patented Apr. 1 1958 ing means may be a separate flanged collar 12 as show in Fig. 2.

Fei-rule 11 has a central bore 13 which is cylindrical in its proximal part but has the form of hollow inverted circular cone 14 in its distal part. The exterior of the ferrule is provided in its proximal part with a male thread 15 adapted to mate with the female thread 16 in'the distal end of a syringe 17 as shown in Fig. 3. l i An alternative form of ferrule 111 is shown in Fig. 2. This diers from ferrule 11 (Fig. l) in having a llange 18 to furnish a bearing for crimping collarr12, and in lacking an exterior thread such as 15. This type of fer- .rule is suitable for use in syringes in vwhich the cartridge is secured against longitudinal movement by means other than a threaded connection. Y l At or near the distal end our ferrule is preferably provided with a fillet 19 serving to aid in securing an injection needle 20 in a desired position as described below. The double-pointed injection needle 20 is fixedly mounted in the axis of a hub 21 with its proximal point 22 projecting from hub 21 as shown in Figs.,1. and`v2. The hub is made of an elastic or lspringy material; this is preferably a synthetic plastic, but alternatively may be a metal of suitable characteristics. Proximally hub 21 has an internal bore l23 in which is located a solid in-v verted circular cone 24 adapted to mate with and form a taper joint with hollow `cone 14. Bore 23 is defined by a resilient cylindrical exterior skirt 25 and at both its proximal and distal ends is provided with circumferential grooves 26 and 27 adapted to mate with llet 19.

When `assembled for packaging, hub `Z1 is slipped over ferrule 11 far enough so that groove 26 is sprungover fillet 19 as permitted by the elasticity of the hub material.- This engagement of groove and fillet prevents accidental displacement of the needle prior to preparation of the syringe for injection.

Before use for injection, the hub is moved' further proximally with relation to the ferrule so that cone`24 seats in conical bore 14, forming a firm taper joint. vThe dimensions of hub and ferrule are so chosen vthat when cone 24 is seated in conical bore 14, needle point 22 pene-I trates closure 7 or 8 and simultaneously groove 27 snaps over fillet 19. In this position the taper joint 14-24 assures a rigid positioning of the needle and the engagement of groove 27 with fillet 19 prevents accidental withdrawal of the needle.

In packaged form needle 20 is provided witha sheath 28 of rubber or similar flexible elastomer. This sheath is closed at its distal end 29 and at its proximal end 30 fits snugly over hub 21 and a portion of ferrule 11. The main function of sheath 28 is to maintain sterility of needle land hub prior to use.

In assembly, the cartridge-needle unit is sterilized by any suitable conventional method.

To give an injection with the units illustrated in Figs. 1-3, the user inserts and secures the unit in a syringe (as in Fig. 3 for example), grips `sheath 28 with his fingers opposite hub 21 and presses the hub towards the syringe. This forces cone 24 to seat itself in tapered bore 14, simultaneously snapping circular groove 27 over fillet 19 and causing point 22 of needle 20 to penetrate closure 7 or 8 as the case may be. A firm seat is thus provided for needle 20 when it is in communication with the contents 2 of tube 1.

Up to this point there is no need for the user to take precautions against contamination of the needle since it is still protected by the sheath. It is thus possible for a number of syringes to be prepared and laid out at one time, e. g. when multiple injections are to be given to one or a series of patients.

When ready, the user slips off the sheath and makes the injection.

Application of our invention to a disposable or one shot syringe is illustrated in Fig. 4. l'n such syringes the drug-containing tube 201 itself serves as the syringe body. It is provided with a finger lange 31, and push rod 2%5 doubles asa protective needle cover. The push rod has an outside diameter sutiiciently small to pass through the bore of tube 201 and has an internal bore 32 suiiiciently large to accommodate needle and sheath. lt is provided at its proximal end externally with a iiange 206, serving as althumb piece, and internally with a female thread 236 mating with male thread 15, and serving to retain the rod in position until the syringe is used. At its distal end rod 205 is provided with a female thread 32 adapted to mate with the thread on stud 4. Y

fThe user of the syringe of Fig. 4 first removes rod 205,from ferrule 11, aixes it byrthread 32 and stud ft to plunger 3 and manipulates hub 24, as described in connection with Figs. 1-3, to cause the proximal end 22 of needle 20 to penetrate the cartridge closure 7. Then, immediately before injection, he slips off sheath 28 to expose the sterile needle.

Hub 24 is advantageously made of a synthetic polymer having a moderate degree of elasticity, such as will permit grooves 26 and 27 to pass over and engage ferrule 19,'but having suicient body to provide a firm mount for the needle when taper joint 14--24 is engaged. Numerous resins meeting these requirements are available commercially, one such being rigid polyethylene produced commercially'by several manufacturers. If more resiliency is required, as for example in a metal hub, the skirt 125 of a modified hub 121 may be provided with a series of longitudinal slots 33, as shown in Fig. 5.

From the above description it will be seen that we have provided a cartridge-needle unit having a hollow needle firmly mounted out of contact with the cartridge contents but ladapted by a simple linear movement to be brought into communication with the cartridge contents, in which position it is held rigidly and without wobble. The unit is adapted to be packaged and distributed with the needle and hub in sterile condition and protected against contamination; accidental penetration of the cartridge closure by the needle is eliminated.

In the specification and claims distal is used to denote a position or direction towards the needle andV proximal a position or direction towards the plunger.

We claim:

1. A cartridge-needle unit comprising a ferrule crimped around the anged end of a drug-containing tube,` a penetrable closure secured to the anged end of the tube by i.

end with a solid inverted cylindrical cone adapted to mate with the hollow cone of the ferrule and being provided with a resilient skirt surrounding the solid cone and adapted to tit friction-tight over the distal end of the terrule, the needle hub being engaged with the ferrule a suicient distance to bring a point of the needle close to but not penetrating the cartridge closure, the dimensions of ferrule and hub being so chosen that when the said solid cone is seated in said hollow cone by longitudinal movement of the hub with respect to the ferrule, the needle penetrates the tube closure.

2. A cartridge-needle unit according to claim l in which the ferrule is provided with a iillet near its distal end and the skirt of the hub is provided with an internal circular groove adapted to mate with the fillet.

3. A cartridge-needle unit according to claim l in which the ferrule is provided with a fillet near its distal end and the skirt of the hub is provided with two internal circular grooves adapted to mate with the fillet, the grooves being spaced longitudinally so that one engages the llet when the needle is not in communication with the contents of the tube and one engages the fillet when the needle is in communication with the contents ofthe tube and the solid cone of the hub is seated in the hollow cone of the ferrule.

4. A cartridge-needle unit according to claim 1 having an elastomeric sheath, closed at its distal end, surrounding the needle and at its proximal end surrounding the needle hub friction-tight.

5. A cartridge adapted to be packaged with an injection needle mounted thereon, comprising a tube having a flanged end, a penetrable closure on the flanged end and a ferrule crimped around the lianged end and securing the closure to the tube, said ferrule extending distally from the tube, having an axial bore in the form of an inverted hollow circular cone, and provided with a fillet near its distal end.

6. In combination a syringe body having a barrel adapted to receive a cartridge-needle unit, means to secure a cartridge-needle unit against longitudinal movement, and a cartridge-needle unit as dened in claim l.

7. A cartridge-needle unit as defined in claim l, in which the tube is provided at its proximal end with an exterior flange and which is closed 'at its proximal end by a slideable plunger having a threaded connection, in combination with a rigid hollow needle cover adapted to be removably mounted on the ferrule and surrounding the needle, the needle cover having an outside diameter less than the bore of the tube and having at it-sdistal end a threaded connection adapted to mate with the threaded connection of the slideable plunger, whereby the needle cover may serve as a push rod and the combination constitute a disposable syringe.

Hein' June 5, 1934 Dann Mar. 9, 1954

US2828743A 1957-06-17 1957-06-17 Snap-on cartridge-needle unit Expired - Lifetime US2828743A (en)

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GB181758A GB867972A (en) 1957-06-17 1958-01-20 Snap-on cartridge-needle unit

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Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3074541A (en) * 1959-10-13 1963-01-22 Brunswick Corp Medicinal vial and needle assembly
US3108592A (en) * 1958-10-17 1963-10-29 Novo Terapeutisk Labor As Injection ampoule
US3110309A (en) * 1960-08-15 1963-11-12 Brunswick Corp Plastic cartridge needle assembly
US3150661A (en) * 1962-09-19 1964-09-29 Cook Waite Lab Inc Disposable cartridge and needle unit
US3155093A (en) * 1961-03-09 1964-11-03 Astra Apotekarnes Kem Fab Hypodermic syringe
US3375825A (en) * 1965-09-02 1968-04-02 Becton Dickinson Co Prefilled syringe
US3380450A (en) * 1965-05-10 1968-04-30 William H. Adelberger Sterile disposable plastic prefilled syringe
US3406686A (en) * 1965-01-15 1968-10-22 Becton Dickinson Co Prefilled syringe
US3989044A (en) * 1975-08-11 1976-11-02 Warner-Lambert Company Syringe
US4303069A (en) * 1978-10-30 1981-12-01 Cohen Milton J Hypodermic syringe with needle guide
EP0096314A2 (en) * 1982-06-09 1983-12-21 Becton, Dickinson and Company Syringe assembly with snap-fit components
WO1989010150A1 (en) * 1988-04-18 1989-11-02 Nujenko Pty Ltd Syringe and protective needle sheath
US4927423A (en) * 1986-09-18 1990-05-22 Aktiebolaget Leo Connector and a disposable assembly utilizing said connector
US4994044A (en) * 1988-10-18 1991-02-19 Carmelo Lo Duca Protected needle syringe
US5137511A (en) * 1987-07-08 1992-08-11 Duoject Medical Systems Inc. Syringe
WO1993009826A1 (en) * 1991-11-15 1993-05-27 The Upjohn Company An injection device
US5328484A (en) * 1992-08-12 1994-07-12 Brice Somers Non-reusable syringe for medical purposes
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
WO1995001812A1 (en) * 1993-07-09 1995-01-19 Disetronic Ag Needle system fastening mechanism
US5447500A (en) * 1993-09-29 1995-09-05 Sterling Winthrop, Inc. Collar and cartridge-needle unit assembly
US5489205A (en) * 1988-09-06 1996-02-06 Davis; Warren Syringe tip locking assembly
US5649912A (en) * 1994-03-07 1997-07-22 Bioject, Inc. Ampule filling device
US5851201A (en) * 1996-01-19 1998-12-22 Acacia Laboratories, Inc. Luer connector
US6135771A (en) * 1997-12-02 2000-10-24 Centrix, Inc. Dental cartridge having an attachable delivery portion
WO2003018092A1 (en) 2001-08-21 2003-03-06 Tecpharma Licensing Ag Fastening device for injection needles
US20040054336A1 (en) * 2002-07-03 2004-03-18 Klint Henrik Sonderskov Needle mounting system and a method for mounting a needle assembly
US20040220532A1 (en) * 2003-05-02 2004-11-04 Caizza Richard J. Medical device having releasable retainer
US20040220533A1 (en) * 2003-05-02 2004-11-04 Caizza Richard J. Controlled release structure for attaching medical devices
US20080183140A1 (en) * 2006-11-29 2008-07-31 West Pharmaceutical Services, Inc. Syringe cartridge system
US20090157005A1 (en) * 2003-04-23 2009-06-18 Gonnelli Robert R Hydraulically actuated pump for long duration medicament administration
US20110137287A1 (en) * 2006-03-30 2011-06-09 Valeritas, Inc. Multi-cartridge fluid delivery device
USRE43597E1 (en) * 2000-05-25 2012-08-21 Mary Lucille Pilkington Trust Adapter and method of attachment for “LUER LOK” receptacles
USD675316S1 (en) 2007-08-22 2013-01-29 Novo Nordisk A/S Needle hub
EP2571553B1 (en) * 2010-05-18 2014-08-06 Sanofi-Aventis Deutschland GmbH Needle assembly for drug delivery devices
US8915890B2 (en) 2009-07-30 2014-12-23 Becton, Dickinson And Company Medical device assembly
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
WO2016020655A3 (en) * 2014-08-06 2016-03-31 Owen Mumford Limited Needle tip arrangements

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3783997A (en) * 1972-04-17 1974-01-08 Sherwood Medical Ind Inc Syringe package
DE2703213C3 (en) * 1976-07-06 1980-02-28 Becton, Dickinson And Co., Rutherford, N.J. (V.St.A.)
US4040421A (en) * 1975-04-04 1977-08-09 Becton, Dickinson And Company Hypodermic syringe and attached needle assembly
NL7602038A (en) * 1975-11-05 1977-05-09 Lezard Sa Container-syringe unit.
US4129130A (en) * 1975-11-05 1978-12-12 Federico Bigarella Vial-syringe
GB8706378D0 (en) * 1987-03-18 1987-04-23 Seldoren Ltd Injection device

Citations (2)

* Cited by examiner, † Cited by third party
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US1961490A (en) * 1931-01-20 1934-06-05 George N Hein Syringe equipment
US2671450A (en) * 1953-04-10 1954-03-09 American Home Prod Injection syringe and cartridge

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1961490A (en) * 1931-01-20 1934-06-05 George N Hein Syringe equipment
US2671450A (en) * 1953-04-10 1954-03-09 American Home Prod Injection syringe and cartridge

Cited By (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3108592A (en) * 1958-10-17 1963-10-29 Novo Terapeutisk Labor As Injection ampoule
US3074541A (en) * 1959-10-13 1963-01-22 Brunswick Corp Medicinal vial and needle assembly
US3110309A (en) * 1960-08-15 1963-11-12 Brunswick Corp Plastic cartridge needle assembly
US3155093A (en) * 1961-03-09 1964-11-03 Astra Apotekarnes Kem Fab Hypodermic syringe
US3150661A (en) * 1962-09-19 1964-09-29 Cook Waite Lab Inc Disposable cartridge and needle unit
US3406686A (en) * 1965-01-15 1968-10-22 Becton Dickinson Co Prefilled syringe
US3380450A (en) * 1965-05-10 1968-04-30 William H. Adelberger Sterile disposable plastic prefilled syringe
US3375825A (en) * 1965-09-02 1968-04-02 Becton Dickinson Co Prefilled syringe
US3989044A (en) * 1975-08-11 1976-11-02 Warner-Lambert Company Syringe
US4303069A (en) * 1978-10-30 1981-12-01 Cohen Milton J Hypodermic syringe with needle guide
EP0096314A2 (en) * 1982-06-09 1983-12-21 Becton, Dickinson and Company Syringe assembly with snap-fit components
EP0096314A3 (en) * 1982-06-09 1984-08-01 Becton, Dickinson and Company Syringe assembly with snap-fit components
US4927423A (en) * 1986-09-18 1990-05-22 Aktiebolaget Leo Connector and a disposable assembly utilizing said connector
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
US5137511A (en) * 1987-07-08 1992-08-11 Duoject Medical Systems Inc. Syringe
WO1989010150A1 (en) * 1988-04-18 1989-11-02 Nujenko Pty Ltd Syringe and protective needle sheath
US5489205A (en) * 1988-09-06 1996-02-06 Davis; Warren Syringe tip locking assembly
US4994044A (en) * 1988-10-18 1991-02-19 Carmelo Lo Duca Protected needle syringe
WO1993009826A1 (en) * 1991-11-15 1993-05-27 The Upjohn Company An injection device
US5328484A (en) * 1992-08-12 1994-07-12 Brice Somers Non-reusable syringe for medical purposes
WO1995001812A1 (en) * 1993-07-09 1995-01-19 Disetronic Ag Needle system fastening mechanism
US5611786A (en) * 1993-07-09 1997-03-18 Disetronic Ag Needle system fastening mechanism
US5447500A (en) * 1993-09-29 1995-09-05 Sterling Winthrop, Inc. Collar and cartridge-needle unit assembly
US5649912A (en) * 1994-03-07 1997-07-22 Bioject, Inc. Ampule filling device
US5851201A (en) * 1996-01-19 1998-12-22 Acacia Laboratories, Inc. Luer connector
US6217560B1 (en) 1996-01-19 2001-04-17 Philip L. Ritger Luer connector
US6135771A (en) * 1997-12-02 2000-10-24 Centrix, Inc. Dental cartridge having an attachable delivery portion
EP0919206A3 (en) * 1997-12-02 2002-06-19 Centrix, Inc. Dental cartridge having an attachable delivery portion
USRE43597E1 (en) * 2000-05-25 2012-08-21 Mary Lucille Pilkington Trust Adapter and method of attachment for “LUER LOK” receptacles
WO2003018092A1 (en) 2001-08-21 2003-03-06 Tecpharma Licensing Ag Fastening device for injection needles
US20040186443A1 (en) * 2001-08-21 2004-09-23 Gian-Carlo Covino Fixing device for injection needles
US8114046B2 (en) 2001-08-21 2012-02-14 Tecpharma Licensing Ag Fixing device for injection needles
US8043249B2 (en) * 2001-08-21 2011-10-25 Tecpharma Licensing Ag Fixing device for injection needles
US20090240212A1 (en) * 2001-08-21 2009-09-24 Tecpharma Licensing Ag Fixing device for injection needles
EP1759730A3 (en) * 2001-08-21 2007-08-01 Tecpharma Licensing AG Attachment device for injection needles
EP1759730A2 (en) * 2001-08-21 2007-03-07 Tecpharma Licensing AG Attachment device for injection needles
US7654986B2 (en) 2002-07-03 2010-02-02 Novo Nordisk A/S Needle mounting system and a method for mounting a needle assembly
US8137325B2 (en) 2002-07-03 2012-03-20 Novo Nordisk A/S Needle mounting system and a method for mounting a needle assembly
US20040054336A1 (en) * 2002-07-03 2004-03-18 Klint Henrik Sonderskov Needle mounting system and a method for mounting a needle assembly
US20100211014A1 (en) * 2002-07-03 2010-08-19 Novo Nordisk A/S Needle Mounting System And A Method For Mounting A Needle Assembly
US20080015519A1 (en) * 2002-07-03 2008-01-17 Novo Nordisk A/S Needle Mounting System And A Method For Mounting A Needle Assembly
US7762994B2 (en) 2002-07-03 2010-07-27 Novo Nordisk A/S Needle mounting system and a method for mounting a needle assembly
US8579869B2 (en) 2002-07-03 2013-11-12 Novo Nordisk A/S Needle mounting system and a method for mounting a needle assembly
US20090198185A1 (en) * 2003-04-23 2009-08-06 Gonnelli Robert R Hydraulically actuated pump for long duration medicament administration
US9072828B2 (en) 2003-04-23 2015-07-07 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
US20090157005A1 (en) * 2003-04-23 2009-06-18 Gonnelli Robert R Hydraulically actuated pump for long duration medicament administration
US9125983B2 (en) 2003-04-23 2015-09-08 Valeritas, Inc. Hydraulically actuated pump for fluid administration
US9511187B2 (en) 2003-04-23 2016-12-06 Valeritas, Inc. Hydraulically actuated pump for fluid administration
US8070726B2 (en) 2003-04-23 2011-12-06 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
US20100217191A1 (en) * 2003-04-23 2010-08-26 Valeritas, Inc. Hydraulically actuated pump for fluid administration
US20040220533A1 (en) * 2003-05-02 2004-11-04 Caizza Richard J. Controlled release structure for attaching medical devices
US9259538B2 (en) 2003-05-02 2016-02-16 Becton, Dickinson And Company Controlled release structure for attaching medical devices
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