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Means for applying coatings to tablets or the like

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US2799241A
US2799241A US33552753A US2799241A US 2799241 A US2799241 A US 2799241A US 33552753 A US33552753 A US 33552753A US 2799241 A US2799241 A US 2799241A
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Prior art keywords
air
tablets
coating
chamber
screen
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Dale E Wurster
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Wisconsin Alumni Research Foundation
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Wisconsin Alumni Research Foundation
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/02Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
    • A23G3/20Apparatus for coating or filling sweetmeats or confectionery
    • A23G3/2076Apparatus for coating with powders or granules, e.g. sprinkling
    • A23G3/2084Apparatus for coating with powders or granules, e.g. sprinkling the solid particles being in a fluidised bed or whirling bed, e.g. conveyed fluidised bed
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/02Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
    • A23G3/20Apparatus for coating or filling sweetmeats or confectionery
    • A23G3/2092Apparatus for coating with atomised liquid, droplet bed, liquid spray
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/003Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic followed by coating of the granules

Description

. i. (Jigy 9 D. E. WURSTER 2,799,241

MEANS FOR APPLYING COATINGS TO TABLETS OR THE LIKE Original Filed Jan. 21, 1949 RECOVERY Am: I Ex www- ALONG WALL OF 10 A Cum-1m: CHAMBER 6 'llbfibhhdr Q 7 3 INLET Compnzssco 2 POWDERED AIR Lac-rose ACACIA SOLUTION o HEATmr: 5UGAR Emmanu- Soun-lon Ram CAOMPRESSEO OUTLET To POLISHING 22 PAN AIR

IN VEN TOR.

United States Patent MEANS FOR APPLYING COATINGS TO TABLETS OR THE LIKE Dale E. Wurster, Madison, Wis,

Alumni Research Foundation, Madison, ration of Wisconsin assignor to Wisconsin =Wis., a corpo- 21, 1949, Serial No. 71,977, dated August 11, 1953. Di-

Serial No.

8 Claims. (Cl. 118-24) My invention relates, generally, to methods of and means for applying coatings, and it has particular relation to the coating of medicinal tablets, chewing gum, candy, nuts, etc. This application is a division of application Serial No. 71,997, filed January 21, 1949, now Patent No. 2,648,609, issued August ll, 1953.

Among the objects of my invention are: To support the tablets in air in a coating chamber and to coat the same while they are so positioned; to support the tablets in an upwardly flowing air stream; to 'heat the air prior to its contact with the tablets to dry the coating thereon; to cause the air to flow in a turbulent fashion and tumble the tablets so that they may be coated uniformly; to move the tablets downwardly on a bias transversely of the air stream while they are being coated; to introduce the coating material into the air stream underneath its initial contact point with the tablets; to introduce individually into the air stream different coating materials; and to direct a current of air upwardly in the coating chamber along its inner surface to prevent the coating material from impinging .thereon.

Other objects of my invention will, and in part appear hereinafter.

This invention is disclosed in the embodiment thereof shown in the accompanying drawing and it comprises the features of construction, combination of elements and arrangement of parts which will be set forth in detail hereinafter and the scope of .the application of which will be indicated in the appended claims.

For a more complete understanding of the nature and scope of my invention, reference can be had to the following detailed description, taken together with the accompanying drawing, in which:

Figure 1 is a longitudinal-sectional view of a coating mechanism constructed ,in accordance with my invention;

Figure 2 is a view partly in section and partly in elevain part, be obvious 2,799,241 Patented July 16, 1957 tube 17 may discharge into a polishing pan .or similar receptacle. Slides 18 and 19 may be provided in the outlet tube 17 for controlling the flow of the coated tab lets therethrough in batches similar to the manner in which they are permitted to flow onto the screen 15 by the slides 13 and 14.

It is desirable that the uncoated and partially coated tablets above the screen 15 be supported in air so that they can be evenly coated. For this purpose air jets 20 and 21 are positioned in the lower end of the chamber 10 below the screen 15 and are directed upwardly to supply an air stream flowing upwardly in the chamber 10 of sufiicient velocity to maintain the uncoated and partially coated tablets slightly out of contact with the screen 15. The air jets 20 and 21 may be connected by conduits 20' and 21 to a suitable source of compressed air, the pressure of which is adjusted so as to maintain the 111117 coated and partially coated tablets slightly above the screen 15 to be coated in a manner to be described presently.

Not only is it desirable that the tablets be supported in the air stream which flows upwardly through the coating chamber 10 but also it is desirable that they be tumbled so as .to coat the same more uniformly. For this purpose the flow of air through the coating chamber 10 is arranged so that, in place of it being a streamlined flow, it is a turbulent flow. For this purpose a disc 22 is provided which may be rotated at ,a constantspeed by ,a motor 23. As shown more clearly in Figure 3 the .disc 22 has circular rows 24, 25, 26, and :27 of perforations through whichthe air from the jets 20 and 21 flows. As shown in Figure 1 the air jets 20 and 21 register with the circular rows 24, '25, '26 and 27 of perforations .so that the air from the former is directed by the row of perforations individual thereto. Also as shown in Figure '1 the rows 24 and 27 of the perforations are inclined-inwardly while the row 25 of perforations is inclined outwardly. The remaining row 26 extends vertically through the disc 22. The several air streams thus directed by the perforations 24, 25, 26, and 27 impinge on the uncoated and partially coated tablets above the screen 15 in a turbulent fashionand cause them-to be tumbled so thatthey tion at an enlarged scale showing in more detail the construction of the manifold which directs air upwardly along the inner surface of the coating chamber; and

Figure 3 is a top plan view of the rotating disc which causes the air to flow in a turbulent fashion.

Referring now particularly to'the drawing, it will be observed that the reference character 10 designates a vertically positioned coating chamber which may be formed of metal or glass. The coating chamber 10 preferably has a circular cross section, and it may be of conical, modified conical, or cylindrical shape as may be desired. Near its lower end there is provided an entrance 11 for the tablets to be coated. An inlet tube 12 communicates with the entrance 11 and slides 13 and 14 are positioned therein to permit the introduction of the tablets to be coated into the chamber 10 in batches.

Within the chamber 10 there is a screen 15 which extends transversely thereacross and on a bias so that the tablets to be coated, and while they are being coated, move across the chamber 10 and downwardly to an exit 16 with which an outlet tube 17 communicates. The

can be evenly and completely coated with the coating material.

With a view to dryingquickly the coating material on the tablets, provision is made for heating the air as it passes upwardly through the :chamber 10 underneath the screen 15. For this purpose an electric heater element 28,in the form of a grid, may be positioned immediately above the rotating disc 22. It will be understood that the heater element 28 may be connected for energization to a suitable current source and .that the degree of heat can be varied by varying the amount of current flowing therethrough.

mined'by the number of -.different.coating materials -to be employed. Each of itheconduits ;30, 31 and :32 terminates in a nozzle 33 which, as shown in Figure l, is directed against the tablets near the upper edge of the screen 15 so that the coating material is supplied to the tablets as soon as they pass through the entrance 11. It will be understood that various coating materials can be supplied. As illustrated in Figure 1, the conduit 30 is arranged to have powdered lactose blown therethrough. The conduit 31 carries an acacia solution, while the conduit 32 may carry a sugar solution. It will be understood that these particular materials are mentioned for illustrative purposes only and that other coating materials can be used as may be desired.

Certain of the coating materials may tend to adhere to the inner surface of the coating chamber particularly in the immediate vicinity of the screen 15. In order to prevent this a ring-like manifold 34 may be positioned just above the screen 15. As shown in Figure 2 the manifold 34 has outwardly and upwardly directed openings or apertures 35 which cause air supplied to the manifold 34 from a suitable source of compressed air to flow in the directions indicated by the arrows 36 over the inner surface of the chamber 10 for preventing the coating material from engaging the same.

At the upper end of the coating chamber 10 a screen 37 may be provided to prevent the escape of tablets in the event that the pressure supplied through the jets and 21 should be sufficiently great as to cause them to rise to this position. An exhaust tube 38 connects the coating chamber 10 to a suitable recovery and exhaust chamber as will be understood readily.

In operation, the motor 23 is energized to drive the disc 22 at the desired speed. Air under pressure is supplied through the conduits 20' and 21' to the jets 20 and 21 respectivelyso that the uncoated and partially coated tablets on the screen 15 will be tumbled thereabove. This air pressure also is adjusted so that when the tablets are fully coated it will be insufiicient to maintain them above the screen 15 at the lower end thereof adjacent the exit 16. The current flowing through the heating element 28 is adjusted so that the coating applied to the tablets above the screen 15 is dried satisfactorily. The coating materials supplied to the conduits 30, 31 and 32 are arranged and adjusted so that the desired proportions will be applied to the tablets at rates which will provide the desired thickness of coating. Air is supplied to the manifold 34, it being understood that the pressure at the apertures 35 therein is slightly greater than the air pressure at the air jets 20 and 21 so that the desired air flow takes place along the inner surface of the chamber 10 to prevent the coating material from impinging thereon.

Now, the slide 13 is raised to permit a charge of uncoated tablets to flow downwardly through the inlet tube 12 against the slide 14. The slide 13 is closed and then the slide 14 is opened. The uncoated tablets flow through the entrance 11 onto the upper end of the screen 15 and are immediately lifted thereabove and tumbled. At the same time they are subjected to the atomized flow of coating materials from the nozzles 33 which are supplied individually by the conduits 30, 31 and 32 in the manner described. The partially coated tablets move transversely of the chamber 10 and downwardly on a bias but are still being tumbled above the screen 15 until the coating thereon is sufliciently heavy so that the upwardly flowing air stream is insufiicient to maintain them out of contact with the screen 15. When all of the tablets have been completely coated, the slide 18 is opened and they are allowed to discharge through the exit 16 into the outlet tube 17. Thereafter the slide 18 is closed and the slide 19 is opened to permit the coated tablets to be discharged into the polishing pan or other receptacle as may be desired.

It will be obvious that certain changes can be made in the foregoing construction without departing from the spirit and scope of this invention. Accordingly, it is intended that all matter shown in the accompanying drawing and described hereinbefore shall be interpreted as illustrative and not in a limiting sense.

I claim as my invention:

1. Apparatus for coating tablets or the like comprising, in combination, a vertically disposed coating chamber, screen means extending transversely of said chamber at its lower end for receiving the tablets to be coated, means for directing an air stream through said chamber in a vertical direction to react against the under sides of the tablets and suspend them in the lower part of said chamber against the force of gravity above said screen, and conduit means extending into said chamber for introducing the coating material into the air stream below the suspended tablets.

2. The invention, as set forth in claim 1, wherein means are provided for heating the air stream prior to contact with the tablets to dry quickly the coating applied thereto.

3. The invention, as set forth in claim 2, wherein means are provided to cause the air stream to flow turbulently to tumble the tablets so that they are coated uniformly.

4. The invention, as set forth in claim 1, wherein the screen means is disposed on a bias in the coating chamber, an entrance for the uncoated tablets is provided through the wall of said chamber at the top of said screen means, and an exit for the coated tablets is provided through the wall of said chamber at the bottom of said screen means.

51 The invention, as set forth in claim 4, wherein the conduit means discharges the coating material into the air stream near the top of the screen means and the velocity of the air stream is such that the uncoated and partially coated tablets are tumbled while the fully coated tablets are too heavy to be tumbled and fall to the lower end of said screen means.

6. The invention, as set forth in claim 1, wherein the conduit means comprises a plurality of conduits each arranged to introduce a separate coating material into the air stream.

7. The invention, as set forth in claim 1, wherein means are provided for directing a flow of air upwardly along the inner surface of the coating chamber above the screen means to prevent the coating material from impinging on said surface.

8. The invention, as set forth in claim 7, wherein the pressure at which the air is directed upwardly along the inner surface of the housing is greater than the pressure at which the air stream is directed upwardly for the support of the tablets.

References Cited in the file of this patent UNITED STATES PATENTS 1,473,165 Steigmeyer Nov. 6, 1923 1,546,922 Faber July 21, 1925 1,854,100 Brito Apr. 12, 1932 2,114,377 Goss Apr. 19, 1938 2,227,465 Roche et al. Jan. 7, 1941 2,339,932 Kuhl Jan. 25, 1944 2,561,392 Marshall July 24, 1951 2,563,475 Mahoney Aug. 7, 1951 2,648,609 Wurster Aug. 11, 1953

US2799241A 1949-01-21 1953-02-06 Means for applying coatings to tablets or the like Expired - Lifetime US2799241A (en)

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Cited By (176)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2944512A (en) * 1956-07-17 1960-07-12 Martin Co Method and apparatus for spray painting small articles
US2986475A (en) * 1958-11-05 1961-05-30 Smith Kline French Lab Apparatus and method for coating discrete solids
US3075885A (en) * 1957-07-12 1963-01-29 Marissal Georges Process for the stabilization by physical means of thermomineral planktonic complexes
US3089824A (en) * 1959-04-30 1963-05-14 Wisconsin Alumui Res Foundatio Granulating and coating process for uniform granules
US3106492A (en) * 1961-09-01 1963-10-08 Upjohn Co Apparatus for coating discrete solids
DE1158481B (en) * 1959-11-09 1963-12-05 Wisconsin Alumni Res Found A process for coating of particles with a coating material in a fluidized bed
US3117027A (en) * 1960-01-08 1964-01-07 Wisconsin Alumni Res Found Apparatus for coating particles in a fluidized bed
US3132075A (en) * 1960-10-17 1964-05-05 Upjohn Co Solid medicinal dosage forms coated with hydroxyethylcellulose and hydrolyzed styrene-maleic anhydride copolymer
US3145146A (en) * 1961-10-31 1964-08-18 Warner Lambert Pharmaceutical Modified mannitol for pharmaceutical tablets
US3148070A (en) * 1961-03-24 1964-09-08 Afico Sa Aromatization of powdered coffee products
DE1184459B (en) * 1962-01-20 1964-12-31 Boehringer & Soehne Gmbh panning
US3177845A (en) * 1960-07-11 1965-04-13 Wood B Hedgepeth Device for cooling and finishing foods
DE1205497B (en) * 1960-02-26 1965-11-25 Abbott Lab A method for applying a coating to discrete finely divided, preferably fragile particles
US3253944A (en) * 1964-01-13 1966-05-31 Wisconsin Alumni Res Found Particle coating process
US3357398A (en) * 1962-09-28 1967-12-12 Abbott Lab Method and apparatus for coating tablets
US3411480A (en) * 1964-01-31 1968-11-19 Smith Kline French Lab Device for coating fine solids
US3533829A (en) * 1965-12-14 1970-10-13 Azote & Prod Chim Process and apparatus for solidifying and granulating a paste
US3880116A (en) * 1974-02-14 1975-04-29 Arnar Stone Lab Particle coating apparatus
US4044713A (en) * 1974-02-20 1977-08-30 Zenyaku Kogyo Kabushiki Kaisha Tumbing apparatus
US4141316A (en) * 1976-01-23 1979-02-27 Gustav Grun Apparatus for the treatment of powdery or granular material
US4615698A (en) * 1984-03-23 1986-10-07 Alza Corporation Total agent osmotic delivery system
US4639383A (en) * 1983-09-20 1987-01-27 Thomas Engineering, Inc. Method and apparatus for coating particulate granules
US4764380A (en) * 1982-03-22 1988-08-16 Alza Corporation Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
US4772477A (en) * 1986-10-17 1988-09-20 Balchem Corporation Meat acidulant
US4801461A (en) * 1987-01-28 1989-01-31 Alza Corporation Pseudoephedrine dosage form
US4803092A (en) * 1986-10-17 1989-02-07 Balchem Corporation Method of acidulating a comminuted meat product
US4851232A (en) * 1987-02-13 1989-07-25 Alza Corporation Drug delivery system with means for obtaining desirable in vivo release rate pattern
US4915952A (en) * 1987-02-27 1990-04-10 Alza Corporation Composition comprising drug, HPC, HPMC and PEO
US4931285A (en) * 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
US4969884A (en) * 1988-12-28 1990-11-13 Alza Corporation Osmotically driven syringe
US5018909A (en) * 1990-04-13 1991-05-28 Nordson Corporation Powder feed hopper
US5019396A (en) * 1989-05-12 1991-05-28 Alza Corporation Delivery dispenser for treating cardiac arrhythmias
US5023076A (en) * 1987-02-27 1991-06-11 Alza Corporation Lamina comprising carboxyvinyl polymer
US5024842A (en) * 1988-04-28 1991-06-18 Alza Corporation Annealed coats
US5024843A (en) * 1989-09-05 1991-06-18 Alza Corporation Oral hypoglycemic glipizide granulation
US5035897A (en) * 1989-09-05 1991-07-30 Alza Corporation Dosage form for delivering soluble or insoluble drugs
US5091190A (en) * 1989-09-05 1992-02-25 Alza Corporation Delivery system for administration blood-glucose lowering drug
US5096716A (en) * 1988-09-01 1992-03-17 Alza Corporation Dosage form for administering calcium antagonist nicardipine
US5098714A (en) * 1989-11-16 1992-03-24 Alza Corporation Osmotic, oral dosage form for fertility control
US5166145A (en) * 1990-09-10 1992-11-24 Alza Corporation Antiemetic therapy
US5178867A (en) * 1991-08-19 1993-01-12 Alza Corporation Dosage form for delivering drug in short-time period
US5185158A (en) * 1992-02-27 1993-02-09 Alza Corporation Dosage form comprising succinimide drug for treating depressive disorders and composition comprising same
US5186942A (en) * 1989-01-30 1993-02-16 Alza Corporation Nicardipine therapy
US5190775A (en) * 1991-05-29 1993-03-02 Balchem Corporation Encapsulated bioactive substances
US5200194A (en) * 1991-12-18 1993-04-06 Alza Corporation Oral osmotic device
US5200197A (en) * 1989-11-16 1993-04-06 Alza Corporation Contraceptive pill
US5207933A (en) * 1991-08-28 1993-05-04 The Procter & Gamble Company Liquid fabric softener with insoluble particles stably suspended by soil release polymer
US5232612A (en) * 1991-08-28 1993-08-03 The Procter & Gamble Company Solid, particulate fabric softener with protected, dryer-activated, cyclodextrin/perfume complex
US5232613A (en) * 1991-08-28 1993-08-03 The Procter & Gamble Company Process for preparing protected particles of water sensitive material
US5234611A (en) * 1991-08-28 1993-08-10 The Procter & Gamble Company Fabric softener, preferably liquid, with protected, dryer-activated, cyclodextrin/perfume complex
US5236615A (en) * 1991-08-28 1993-08-17 The Procter & Gamble Company Solid, particulate detergent composition with protected, dryer-activated, water sensitive material
US5246711A (en) * 1992-02-27 1993-09-21 Alza Corporation Dosage form for treating dysthymia
US5246710A (en) * 1992-02-27 1993-09-21 Alza Corporation Dosage form for treating cyclothymia
US5254168A (en) * 1992-06-04 1993-10-19 Howard Littman Coating apparatus having opposed atomizing nozzles in a fluid bed column
US5296219A (en) * 1990-06-15 1994-03-22 Rhone-Poulenc Nutrition Animale Process for coating active principles using a pH-sensitive polymer
EP0588707A1 (en) 1992-09-18 1994-03-23 Rhone-Poulenc Nutrition Animale Chitosan-based nutrient and drug compositions for administration to ruminants
US5330762A (en) * 1992-02-27 1994-07-19 Alza Corporation Tandospiaine antidepressive therapy
US5350659A (en) * 1993-03-31 1994-09-27 Xerox Corporation Preparation of conductive toners using fluidized bed processing equipment
US5358721A (en) * 1992-12-04 1994-10-25 Alza Corporation Antiviral therapy
US5532003A (en) * 1994-01-18 1996-07-02 Alza Corporation Pentoxifylline therapy
US5540665A (en) * 1994-01-31 1996-07-30 Alza Corporation Gas driven dispensing device and gas generating engine therefor
US5567238A (en) * 1994-12-06 1996-10-22 Coating Machinery Systems, Inc. Oscillating bed seed coating machine for particulate material
US5591454A (en) * 1989-09-05 1997-01-07 Alza Corporation Method for lowering blood glucose
US5595759A (en) * 1994-11-10 1997-01-21 Alza Corporation Process for providing therapeutic composition
US5614578A (en) * 1994-10-28 1997-03-25 Alza Corporation Injection-molded dosage form
US5616339A (en) * 1992-09-18 1997-04-01 Rhone-Poulenc Nutrition Animale Chitosan-based nutrient or medicinal compositions for administration to ruminants
US5620705A (en) * 1994-08-04 1997-04-15 Alza Corporation Progestin tablet
US5660861A (en) * 1994-04-28 1997-08-26 Alza Corporation Effective therapy for epilepsies
US5688518A (en) * 1992-02-27 1997-11-18 Alza Corporation Antidepressive therapy
US5698224A (en) * 1994-06-27 1997-12-16 Alza Corporation Tacrine therapy
US5707663A (en) * 1993-05-28 1998-01-13 Alza Corporation Sustained antiepileptic therapy
US5858407A (en) * 1992-02-27 1999-01-12 Alza Corporation Method for administering tandospirone
US6056992A (en) * 1988-06-02 2000-05-02 Campbell Soup Company Encapsulated additives
US6110499A (en) * 1997-07-24 2000-08-29 Alza Corporation Phenytoin therapy
US6124355A (en) * 1995-05-22 2000-09-26 Guittard; George V. Oxybutynin therapy
WO2000062830A2 (en) * 1999-04-19 2000-10-26 Boston Scientific Limited Coating medical devices using air suspension
US6210712B1 (en) 1997-12-05 2001-04-03 Alza Corporation Dosage form having first and second coats
US6262115B1 (en) 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
US20010009995A1 (en) * 1998-03-26 2001-07-26 Gupta Suneel K. Oxybutynin therapy
US6312521B1 (en) 1998-12-14 2001-11-06 Primera Foods Corporation Apparatus and process for coating particles
US20010038856A1 (en) * 1994-07-07 2001-11-08 Sonya Merrill Hydromorphone therapy
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
US6361795B1 (en) 1989-09-05 2002-03-26 Alza Corporation Method for lowering blood glucose
US20020048600A1 (en) * 1998-11-02 2002-04-25 Padmanabh Bhatt Controlled delivery of active agents
US6379498B1 (en) 2000-02-28 2002-04-30 Kimberly-Clark Worldwide, Inc. Method for adding an adsorbable chemical additive to pulp during the pulp processing and products made by said method
US20020071863A1 (en) * 1999-12-09 2002-06-13 Dong Liang C. Antiviral medication
US20020098242A1 (en) * 1997-07-31 2002-07-25 Darder Carlos Picornell Oral pharmaceutical preparation comprising an antiulcer activity compound, and process for its production
US6440457B1 (en) 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
US20020160045A1 (en) * 1998-06-05 2002-10-31 Desjardin Michael A. Therapeutic dosage form for delivering oxybutynin
US6514530B2 (en) 1997-09-09 2003-02-04 Alza Corporation Dosage form comprising means for changing drug delivery shape
US20030062641A1 (en) * 2001-08-16 2003-04-03 Niraj Vasishtha Microencapsulation using electromagnetic energy and core and shell materials with different dielectric constants and dissipation factors
US6582560B2 (en) 2001-03-07 2003-06-24 Kimberly-Clark Worldwide, Inc. Method for using water insoluble chemical additives with pulp and products made by said method
US20030125714A1 (en) * 2001-12-18 2003-07-03 Edgren David Emil Dosage form for time-varying patterns of drug delivery
US20030165614A1 (en) * 2002-03-01 2003-09-04 Henrik Hansen Coating a medical implant using a pan coater
US20030198619A1 (en) * 2001-12-19 2003-10-23 Dong Liang C. Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
US20030224051A1 (en) * 2002-05-31 2003-12-04 Fink Tracy A. Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone
US20030232078A1 (en) * 2001-12-19 2003-12-18 Dong Liang C. Formulation & dosage form for the controlled delivery of therapeutic agents
US20040010000A1 (en) * 2002-04-29 2004-01-15 Ayer Atul D. Methods and dosage forms for controlled delivery of oxycodone
US6685775B1 (en) 2002-02-19 2004-02-03 Vector Corporation Wurster air diverter
US20040045687A1 (en) * 2002-09-11 2004-03-11 Shannon Thomas Gerard Method for using water insoluble chemical additives with pulp and products made by said method
US6706282B1 (en) 1998-11-02 2004-03-16 Evangeline Cruz Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones
US20040062799A1 (en) * 1997-09-29 2004-04-01 Ayer Atul D. Therapeutic composition and delivery system for administering drug
US6730349B2 (en) 1999-04-19 2004-05-04 Scimed Life Systems, Inc. Mechanical and acoustical suspension coating of medical implants
US20040091529A1 (en) * 2002-06-26 2004-05-13 David Edgren Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
US6740406B2 (en) 2000-12-15 2004-05-25 Kimberly-Clark Worldwide, Inc. Coated activated carbon
US20040115262A1 (en) * 2002-07-29 2004-06-17 Frank Jao Formulations and dosage forms for controlled delivery of topiramate
US20040115315A1 (en) * 2002-08-02 2004-06-17 Camelot Damien Michel Andre Encapsulated crystalline lactic acid
US6767553B2 (en) 2001-12-18 2004-07-27 Kimberly-Clark Worldwide, Inc. Natural fibers treated with acidic odor control/binder systems
US20040166160A1 (en) * 2003-01-14 2004-08-26 Ramkumar Subramanian Methods and dosage forms with modified viscosity layers
US20040191314A1 (en) * 1994-04-28 2004-09-30 Frank Jao Antiepileptic dosage form and process for protecting antiepileptic drug
US20040197407A1 (en) * 2003-02-11 2004-10-07 Ramkumar Subramanian Methods and dosage forms with modified layer geometry
US20050003006A1 (en) * 1997-09-09 2005-01-06 Alza Corporation Pharmaceutical coating composition and method of use
US20050025831A1 (en) * 1996-11-12 2005-02-03 Alza Corporation Methods and devices for providing prolonged drug therapy
US6852904B2 (en) 2001-12-18 2005-02-08 Kimberly-Clark Worldwide, Inc. Cellulose fibers treated with acidic odor control agents
US20050058707A1 (en) * 2003-08-06 2005-03-17 Iran Reyes Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
US20050069587A1 (en) * 2003-09-02 2005-03-31 Modi Nishit Bachulal Novel drug compositions and dosage forms of topiramate
US20050089570A1 (en) * 2003-09-26 2005-04-28 Evangeline Cruz Oros push-stick for controlled delivery of active agents
US20050106249A1 (en) * 2002-04-29 2005-05-19 Stephen Hwang Once-a-day, oral, controlled-release, oxycodone dosage forms
US20050112195A1 (en) * 2003-09-26 2005-05-26 Evangeline Cruz Drug coating providing high drug loading and methods for providing same
US20050136108A1 (en) * 2003-08-22 2005-06-23 Yam Noymi V. Stepwise delivery of topiramate over prolonged period of time
US20050148594A1 (en) * 2002-12-17 2005-07-07 Cink Russell D. Salts of fenofibric acid and pharmaceutical formulations thereof
US20050158382A1 (en) * 2003-09-26 2005-07-21 Evangeline Cruz Controlled release formulations of opioid and nonopioid analgesics
US20050169992A1 (en) * 2003-12-23 2005-08-04 Frank Jao Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
US20050175690A1 (en) * 2003-12-29 2005-08-11 David Edgren Novel drug compositions and dosage forms
US20050175697A1 (en) * 2003-12-29 2005-08-11 David Edgren Novel drug compositions and dosage forms of topiramate
US20050220879A1 (en) * 1999-12-16 2005-10-06 Alza Corporation Dosage forms having a barrier layer to laser ablation
US20050232995A1 (en) * 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US20050287212A1 (en) * 2004-06-28 2005-12-29 Liang-Chang Dong Oral delivery system comprising a drug/polymer complex
US20050287213A1 (en) * 2004-06-28 2005-12-29 Wong Patrick S Dosage forms for low solubility and or low dissolution rate free acid pharmaceutical agents
US20060009425A1 (en) * 2004-05-28 2006-01-12 Leticia Delgado-Herrera Oral formulations of paricalcitol
US20060057206A1 (en) * 2004-08-19 2006-03-16 Wong Patrick S Controlled release nanoparticle active agent formulation dosage forms and methods
EP1652516A2 (en) 1998-11-02 2006-05-03 ALZA Corporation Osmotic controlled delivery of active agents
US7060734B1 (en) 1997-09-09 2006-06-13 Alza Corporation Pharmaceutical coating composition and method of use
WO2006061576A1 (en) * 2004-12-11 2006-06-15 Apv Systems Limited Food item coating apparatus and method
US20060134196A1 (en) * 2002-12-17 2006-06-22 Abbott Gmbh & Co. Kg Formulation comprising fenofibric acid, a physiologically acceptable salt or derivative thereof
US20060153889A1 (en) * 2005-01-10 2006-07-13 Friel Francis M Discontinuous surface coating for particles
US20060251807A1 (en) * 2005-05-06 2006-11-09 Hong Keith C Roofing Granules With Improved Surface Coating Coverage And Functionalities And Method For Producing Same
US7140874B2 (en) 2001-08-06 2006-11-28 Southwest Research Institute Method and apparatus for testing catalytic converter durability
US20070003624A1 (en) * 2005-06-29 2007-01-04 Shanbhag Anant R Semi-permeable compositions providing reduced drying time for osmotic dosage forms
US20070031496A1 (en) * 2005-08-04 2007-02-08 Edgren David E Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties
WO2007053698A2 (en) 2005-10-31 2007-05-10 Alza Corporation Methods of reducing alcohol-induced dose dumping for opioid sustained release oral dosage forms
US20070148342A1 (en) * 2005-12-23 2007-06-28 Kalkanoglu Husnu M Controlled time-release algae resistant roofing system
US20070190137A1 (en) * 2005-10-07 2007-08-16 Reyes Iran Osmotic dosage form with controlled release and fast release aspects
US20070281018A1 (en) * 2004-09-24 2007-12-06 Abbott Laboratories Sustained release formulations of opioid and nonopioid analgesics
US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
US20080152714A1 (en) * 2005-04-08 2008-06-26 Yi Gao Pharmaceutical Formulations
US20080214629A1 (en) * 2007-02-09 2008-09-04 Scott Bull Controlled release compositions of tizanidine
US20090022798A1 (en) * 2007-07-20 2009-01-22 Abbott Gmbh & Co. Kg Formulations of nonopioid and confined opioid analgesics
US20090087484A1 (en) * 2007-09-28 2009-04-02 Alza Corporation Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
EP2074992A1 (en) 2005-04-08 2009-07-01 Abbott Laboratories Pharmaceutical formulations
US20090233874A1 (en) * 2007-09-10 2009-09-17 Abdel-Magid Ahmed F Process for the preparation of compounds useful as inhibitors of sglt
US20090317355A1 (en) * 2006-01-21 2009-12-24 Abbott Gmbh & Co. Kg, Abuse resistant melt extruded formulation having reduced alcohol interaction
US20100047524A1 (en) * 2003-06-20 2010-02-25 Hong Keith C Algae resistant roofing granules with controlled algaecide leaching rates, algae resistant shingles and process for producing same
US20100099883A1 (en) * 2008-10-17 2010-04-22 Walter Ferdinand Maria Fillers Process for the preparation of compounds useful as inhibitors of sglt
US7749356B2 (en) 2001-03-07 2010-07-06 Kimberly-Clark Worldwide, Inc. Method for using water insoluble chemical additives with pulp and products made by said method
US20100172989A1 (en) * 2006-01-21 2010-07-08 Abbott Laboratories Abuse resistant melt extruded formulation having reduced alcohol interaction
US20100189878A1 (en) * 2009-01-26 2010-07-29 Teva Pharmaceutical Industries Ltd. Processes for coating a carrier with microparticles
US20100291208A1 (en) * 2006-10-16 2010-11-18 Jingang Wang Controlled porous osmotic pump tablets of high permeable drugs and the preparation process thereof
US20110009347A1 (en) * 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
US20110087017A1 (en) * 2009-10-14 2011-04-14 Vittorio Farina Process for the preparation of compounds useful as inhibitors of sglt2
US20110159240A1 (en) * 2009-11-24 2011-06-30 Ming Liang Shiao Composite nanoparticles for roofing granules, roofing shingles containing such granules, and process for producing same
US20110217515A1 (en) * 2003-06-20 2011-09-08 Hong Keith C Algae resistant roofing granules with controlled algaecide leaching rates, algae resistant shingles and process for producing same
WO2011143296A1 (en) 2010-05-11 2011-11-17 Janssen Pharmaceutica Nv Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt
WO2012006298A2 (en) 2010-07-06 2012-01-12 Janssen Pharmaceutica Nv Formulation for co-therapy treatment of diabetes
US8354124B2 (en) 2002-12-13 2013-01-15 Durect Corporation Oral drug delivery system
US20130040042A1 (en) * 2011-08-09 2013-02-14 Biomet Biologics, Llc Surgical Mesh Spray and Delivery System
EP2306792A3 (en) * 2009-09-24 2013-04-17 Fachhochschule Hildesheim / Holzminden / Göttingen Method and device for handling objects with a physical plasma at atmospheric pressure
USRE44459E1 (en) 1989-09-05 2013-08-27 Alza Corporation Method for lowering blood glucose
US8772512B2 (en) 2009-07-10 2014-07-08 Janssen Pharmaceutica Nv Crystallisation process for 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene
WO2014179453A1 (en) 2013-04-30 2014-11-06 Abbvie, Inc. Methods for improving lipid profiles using atrasentan
US9035044B2 (en) 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
US9555113B2 (en) 2013-03-15 2017-01-31 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US9592204B2 (en) 2007-12-06 2017-03-14 Durect Corporation Oral pharmaceutical dosage forms
US9616055B2 (en) 2008-11-03 2017-04-11 Durect Corporation Oral pharmaceutical dosage forms

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1473165A (en) * 1922-12-04 1923-11-06 Steigmeyer Frederick Seed-conditioning apparatus
US1546922A (en) * 1925-07-21 Process oe desiccation
US1854100A (en) * 1930-02-21 1932-04-12 Brito Augusto Diaz Process of preparing material for pavements
US2114377A (en) * 1935-03-01 1938-04-19 Carlisle Lumber Company Means for applying coatings
US2227465A (en) * 1938-06-11 1941-01-07 Binks Mfg Co Means for eliminating divided material in industrial processes
US2339932A (en) * 1941-04-10 1944-01-25 Standard Oil Dev Co Chemical process
US2561392A (en) * 1945-08-11 1951-07-24 Donald E Marshall Process and apparatus for treating solutions to recover and coat solid particles
US2563475A (en) * 1951-08-07 Apparatus fob treating granular
US2648609A (en) * 1949-01-21 1953-08-11 Wisconsin Alumni Res Found Method of applying coatings to edible tablets or the like

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1546922A (en) * 1925-07-21 Process oe desiccation
US2563475A (en) * 1951-08-07 Apparatus fob treating granular
US1473165A (en) * 1922-12-04 1923-11-06 Steigmeyer Frederick Seed-conditioning apparatus
US1854100A (en) * 1930-02-21 1932-04-12 Brito Augusto Diaz Process of preparing material for pavements
US2114377A (en) * 1935-03-01 1938-04-19 Carlisle Lumber Company Means for applying coatings
US2227465A (en) * 1938-06-11 1941-01-07 Binks Mfg Co Means for eliminating divided material in industrial processes
US2339932A (en) * 1941-04-10 1944-01-25 Standard Oil Dev Co Chemical process
US2561392A (en) * 1945-08-11 1951-07-24 Donald E Marshall Process and apparatus for treating solutions to recover and coat solid particles
US2648609A (en) * 1949-01-21 1953-08-11 Wisconsin Alumni Res Found Method of applying coatings to edible tablets or the like

Cited By (254)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2944512A (en) * 1956-07-17 1960-07-12 Martin Co Method and apparatus for spray painting small articles
US3075885A (en) * 1957-07-12 1963-01-29 Marissal Georges Process for the stabilization by physical means of thermomineral planktonic complexes
US2986475A (en) * 1958-11-05 1961-05-30 Smith Kline French Lab Apparatus and method for coating discrete solids
US3089824A (en) * 1959-04-30 1963-05-14 Wisconsin Alumui Res Foundatio Granulating and coating process for uniform granules
DE1158481B (en) * 1959-11-09 1963-12-05 Wisconsin Alumni Res Found A process for coating of particles with a coating material in a fluidized bed
US3117027A (en) * 1960-01-08 1964-01-07 Wisconsin Alumni Res Found Apparatus for coating particles in a fluidized bed
DE1205497B (en) * 1960-02-26 1965-11-25 Abbott Lab A method for applying a coating to discrete finely divided, preferably fragile particles
US3177845A (en) * 1960-07-11 1965-04-13 Wood B Hedgepeth Device for cooling and finishing foods
US3132075A (en) * 1960-10-17 1964-05-05 Upjohn Co Solid medicinal dosage forms coated with hydroxyethylcellulose and hydrolyzed styrene-maleic anhydride copolymer
US3148070A (en) * 1961-03-24 1964-09-08 Afico Sa Aromatization of powdered coffee products
US3106492A (en) * 1961-09-01 1963-10-08 Upjohn Co Apparatus for coating discrete solids
US3145146A (en) * 1961-10-31 1964-08-18 Warner Lambert Pharmaceutical Modified mannitol for pharmaceutical tablets
DE1184459B (en) * 1962-01-20 1964-12-31 Boehringer & Soehne Gmbh panning
US3357398A (en) * 1962-09-28 1967-12-12 Abbott Lab Method and apparatus for coating tablets
US3253944A (en) * 1964-01-13 1966-05-31 Wisconsin Alumni Res Found Particle coating process
US3411480A (en) * 1964-01-31 1968-11-19 Smith Kline French Lab Device for coating fine solids
US3533829A (en) * 1965-12-14 1970-10-13 Azote & Prod Chim Process and apparatus for solidifying and granulating a paste
US3880116A (en) * 1974-02-14 1975-04-29 Arnar Stone Lab Particle coating apparatus
US4044713A (en) * 1974-02-20 1977-08-30 Zenyaku Kogyo Kabushiki Kaisha Tumbing apparatus
US4141316A (en) * 1976-01-23 1979-02-27 Gustav Grun Apparatus for the treatment of powdery or granular material
US4764380A (en) * 1982-03-22 1988-08-16 Alza Corporation Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
US4639383A (en) * 1983-09-20 1987-01-27 Thomas Engineering, Inc. Method and apparatus for coating particulate granules
US4615698A (en) * 1984-03-23 1986-10-07 Alza Corporation Total agent osmotic delivery system
US4772477A (en) * 1986-10-17 1988-09-20 Balchem Corporation Meat acidulant
US4803092A (en) * 1986-10-17 1989-02-07 Balchem Corporation Method of acidulating a comminuted meat product
US4801461A (en) * 1987-01-28 1989-01-31 Alza Corporation Pseudoephedrine dosage form
US4851232A (en) * 1987-02-13 1989-07-25 Alza Corporation Drug delivery system with means for obtaining desirable in vivo release rate pattern
US5023076A (en) * 1987-02-27 1991-06-11 Alza Corporation Lamina comprising carboxyvinyl polymer
US4915952A (en) * 1987-02-27 1990-04-10 Alza Corporation Composition comprising drug, HPC, HPMC and PEO
US5024842A (en) * 1988-04-28 1991-06-18 Alza Corporation Annealed coats
US4931285A (en) * 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
US6056992A (en) * 1988-06-02 2000-05-02 Campbell Soup Company Encapsulated additives
US5096716A (en) * 1988-09-01 1992-03-17 Alza Corporation Dosage form for administering calcium antagonist nicardipine
US4969884A (en) * 1988-12-28 1990-11-13 Alza Corporation Osmotically driven syringe
US5186942A (en) * 1989-01-30 1993-02-16 Alza Corporation Nicardipine therapy
US5019396A (en) * 1989-05-12 1991-05-28 Alza Corporation Delivery dispenser for treating cardiac arrhythmias
US5591454A (en) * 1989-09-05 1997-01-07 Alza Corporation Method for lowering blood glucose
US5091190A (en) * 1989-09-05 1992-02-25 Alza Corporation Delivery system for administration blood-glucose lowering drug
US5024843A (en) * 1989-09-05 1991-06-18 Alza Corporation Oral hypoglycemic glipizide granulation
USRE44459E1 (en) 1989-09-05 2013-08-27 Alza Corporation Method for lowering blood glucose
US5545413A (en) * 1989-09-05 1996-08-13 Alza Corporation Dosage form for administering oral hypoglycemic glipizide
US6361795B1 (en) 1989-09-05 2002-03-26 Alza Corporation Method for lowering blood glucose
US5035897A (en) * 1989-09-05 1991-07-30 Alza Corporation Dosage form for delivering soluble or insoluble drugs
US5842476A (en) * 1989-11-16 1998-12-01 Alza Corporation Method for controlling fertility
US5098714A (en) * 1989-11-16 1992-03-24 Alza Corporation Osmotic, oral dosage form for fertility control
US5200197A (en) * 1989-11-16 1993-04-06 Alza Corporation Contraceptive pill
US5018909A (en) * 1990-04-13 1991-05-28 Nordson Corporation Powder feed hopper
US5296219A (en) * 1990-06-15 1994-03-22 Rhone-Poulenc Nutrition Animale Process for coating active principles using a pH-sensitive polymer
US5310561A (en) * 1990-09-10 1994-05-10 Alza Corporation Antiemetic therapy
US5166145A (en) * 1990-09-10 1992-11-24 Alza Corporation Antiemetic therapy
US6013286A (en) * 1991-05-29 2000-01-11 Balchem Corporation Encapsulated bioactive substances
US5190775A (en) * 1991-05-29 1993-03-02 Balchem Corporation Encapsulated bioactive substances
US5178867A (en) * 1991-08-19 1993-01-12 Alza Corporation Dosage form for delivering drug in short-time period
US5207933A (en) * 1991-08-28 1993-05-04 The Procter & Gamble Company Liquid fabric softener with insoluble particles stably suspended by soil release polymer
US5232612A (en) * 1991-08-28 1993-08-03 The Procter & Gamble Company Solid, particulate fabric softener with protected, dryer-activated, cyclodextrin/perfume complex
US5232613A (en) * 1991-08-28 1993-08-03 The Procter & Gamble Company Process for preparing protected particles of water sensitive material
US5236615A (en) * 1991-08-28 1993-08-17 The Procter & Gamble Company Solid, particulate detergent composition with protected, dryer-activated, water sensitive material
US5234611A (en) * 1991-08-28 1993-08-10 The Procter & Gamble Company Fabric softener, preferably liquid, with protected, dryer-activated, cyclodextrin/perfume complex
US5200194A (en) * 1991-12-18 1993-04-06 Alza Corporation Oral osmotic device
US5185158A (en) * 1992-02-27 1993-02-09 Alza Corporation Dosage form comprising succinimide drug for treating depressive disorders and composition comprising same
US5858407A (en) * 1992-02-27 1999-01-12 Alza Corporation Method for administering tandospirone
US5246710A (en) * 1992-02-27 1993-09-21 Alza Corporation Dosage form for treating cyclothymia
US5330762A (en) * 1992-02-27 1994-07-19 Alza Corporation Tandospiaine antidepressive therapy
US5246711A (en) * 1992-02-27 1993-09-21 Alza Corporation Dosage form for treating dysthymia
US5688518A (en) * 1992-02-27 1997-11-18 Alza Corporation Antidepressive therapy
US5254168A (en) * 1992-06-04 1993-10-19 Howard Littman Coating apparatus having opposed atomizing nozzles in a fluid bed column
EP0588707A1 (en) 1992-09-18 1994-03-23 Rhone-Poulenc Nutrition Animale Chitosan-based nutrient and drug compositions for administration to ruminants
US5616339A (en) * 1992-09-18 1997-04-01 Rhone-Poulenc Nutrition Animale Chitosan-based nutrient or medicinal compositions for administration to ruminants
US5358721A (en) * 1992-12-04 1994-10-25 Alza Corporation Antiviral therapy
US5350659A (en) * 1993-03-31 1994-09-27 Xerox Corporation Preparation of conductive toners using fluidized bed processing equipment
US20040092601A1 (en) * 1993-05-27 2004-05-13 Edgren David Emil Antidepressant dosage form
US8084059B2 (en) 1993-05-27 2011-12-27 Alza Corporation Antidepressant dosage form
US6440457B1 (en) 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
US20040086570A1 (en) * 1993-05-27 2004-05-06 Edgren David Emil Antidepressant dosage form
US20070009600A1 (en) * 1993-05-27 2007-01-11 Edgren David E Antidepressant dosage form
US5707663A (en) * 1993-05-28 1998-01-13 Alza Corporation Sustained antiepileptic therapy
US6287598B1 (en) 1993-05-28 2001-09-11 Alza Corporation Method for providing sustained antiepileptic therapy
US5980943A (en) * 1993-05-28 1999-11-09 Alza Corporation Sustained antiepileptic therapy
US5603954A (en) * 1994-01-18 1997-02-18 Alza Corporation Pentoxifylline therapy and method of use
US5532003A (en) * 1994-01-18 1996-07-02 Alza Corporation Pentoxifylline therapy
US5540665A (en) * 1994-01-31 1996-07-30 Alza Corporation Gas driven dispensing device and gas generating engine therefor
US5876750A (en) * 1994-04-28 1999-03-02 Alza Corporation Effective therapy for epilepsies
US5906832A (en) * 1994-04-28 1999-05-25 Alza Corporation Method for treating epilepsies
US5955103A (en) * 1994-04-28 1999-09-21 Alza Corporation Dosage form comprising antiepileptic drug
US20040191314A1 (en) * 1994-04-28 2004-09-30 Frank Jao Antiepileptic dosage form and process for protecting antiepileptic drug
US5863558A (en) * 1994-04-28 1999-01-26 Alza Corporation Effective therapy for epilepsies
US5660861A (en) * 1994-04-28 1997-08-26 Alza Corporation Effective therapy for epilepsies
US5698224A (en) * 1994-06-27 1997-12-16 Alza Corporation Tacrine therapy
US6036973A (en) * 1994-06-27 2000-03-14 Alza Corporation Therapy for neurological diseases
US20100028389A1 (en) * 1994-07-07 2010-02-04 Sonya Merrill Hydromorphone therapy
US20010038856A1 (en) * 1994-07-07 2001-11-08 Sonya Merrill Hydromorphone therapy
US5633011A (en) * 1994-08-04 1997-05-27 Alza Corporation Progesterone replacement therapy
US5770227A (en) * 1994-08-04 1998-06-23 Alza Corporation Progesterone replacement therapy
US5620705A (en) * 1994-08-04 1997-04-15 Alza Corporation Progestin tablet
US5614578A (en) * 1994-10-28 1997-03-25 Alza Corporation Injection-molded dosage form
US5830502A (en) * 1994-10-28 1998-11-03 Alza Corporation Injection-molded dosage form
US5595759A (en) * 1994-11-10 1997-01-21 Alza Corporation Process for providing therapeutic composition
US6274190B1 (en) 1994-12-06 2001-08-14 Coating Machinery Systems, Inc. Method of coating particulate material
US5567238A (en) * 1994-12-06 1996-10-22 Coating Machinery Systems, Inc. Oscillating bed seed coating machine for particulate material
US6919092B2 (en) 1995-05-22 2005-07-19 Alza Corporation Method for the management of incontinence
US6124355A (en) * 1995-05-22 2000-09-26 Guittard; George V. Oxybutynin therapy
US6262115B1 (en) 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
US6930129B2 (en) 1996-11-12 2005-08-16 Alza Corporation Methods and devices for providing prolonged drug therapy
US20050238709A1 (en) * 1996-11-12 2005-10-27 Alza Corporation Methods and devices for providing prolonged drug therapy
US20100093796A1 (en) * 1996-11-12 2010-04-15 Gupta Suneel K Methods and devices for providing prolonged drug therapy
US20050025832A1 (en) * 1996-11-12 2005-02-03 Alza Corporation Methods and devices for providing prolonged drug therapy
US20050025831A1 (en) * 1996-11-12 2005-02-03 Alza Corporation Methods and devices for providing prolonged drug therapy
US8163798B2 (en) 1996-11-12 2012-04-24 Alza Corporation Methods and devices for providing prolonged drug therapy
US9144549B2 (en) 1996-11-12 2015-09-29 Alza Corporation Methods and devices for providing prolonged drug therapy
US9029416B2 (en) 1996-11-12 2015-05-12 Alza Corporation Methods and devices for providing prolonged drug therapy
US9000038B2 (en) 1996-11-12 2015-04-07 Alza Corporation Methods and devices for providing prolonged drug therapy
US8629179B2 (en) 1996-11-12 2014-01-14 Alza Corporation Methods and devices for providing prolonged drug therapy
US6919373B1 (en) 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
US6110499A (en) * 1997-07-24 2000-08-29 Alza Corporation Phenytoin therapy
US20020098242A1 (en) * 1997-07-31 2002-07-25 Darder Carlos Picornell Oral pharmaceutical preparation comprising an antiulcer activity compound, and process for its production
US7087243B2 (en) 1997-09-09 2006-08-08 Edgren David E Pharmaceutical coating composition and method of use
US20050003006A1 (en) * 1997-09-09 2005-01-06 Alza Corporation Pharmaceutical coating composition and method of use
US7060734B1 (en) 1997-09-09 2006-06-13 Alza Corporation Pharmaceutical coating composition and method of use
US6514530B2 (en) 1997-09-09 2003-02-04 Alza Corporation Dosage form comprising means for changing drug delivery shape
US20040062799A1 (en) * 1997-09-29 2004-04-01 Ayer Atul D. Therapeutic composition and delivery system for administering drug
US6210712B1 (en) 1997-12-05 2001-04-03 Alza Corporation Dosage form having first and second coats
US20010009995A1 (en) * 1998-03-26 2001-07-26 Gupta Suneel K. Oxybutynin therapy
US20020160045A1 (en) * 1998-06-05 2002-10-31 Desjardin Michael A. Therapeutic dosage form for delivering oxybutynin
EP1652516A2 (en) 1998-11-02 2006-05-03 ALZA Corporation Osmotic controlled delivery of active agents
US6855334B2 (en) 1998-11-02 2005-02-15 Alta Corporation Controlled delivery of active agents
US20020048600A1 (en) * 1998-11-02 2002-04-25 Padmanabh Bhatt Controlled delivery of active agents
US6706282B1 (en) 1998-11-02 2004-03-16 Evangeline Cruz Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones
US6312521B1 (en) 1998-12-14 2001-11-06 Primera Foods Corporation Apparatus and process for coating particles
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
US6596314B2 (en) 1998-12-23 2003-07-22 Alza Corporation Controlled release liquid active agent formulation dosage forms
US6368658B1 (en) 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
EP1649937A1 (en) * 1999-04-19 2006-04-26 Boston Scientific Limited Coating medical device using air suspension
US7407551B2 (en) 1999-04-19 2008-08-05 Boston Scientific Scimed, Inc. Mechanical and acoustical suspension coating of medical implants
US20110034993A1 (en) * 1999-04-19 2011-02-10 Boston Scientific Scimed, Inc. Coated medical implants
US20040089230A1 (en) * 1999-04-19 2004-05-13 Schwarz Marlene C. Mechanical and acoustical suspension coating of medical implants
WO2000062830A3 (en) * 1999-04-19 2000-12-28 Scimed Life Systems Inc Coating medical devices using air suspension
WO2000062830A2 (en) * 1999-04-19 2000-10-26 Boston Scientific Limited Coating medical devices using air suspension
US6730349B2 (en) 1999-04-19 2004-05-04 Scimed Life Systems, Inc. Mechanical and acoustical suspension coating of medical implants
US20020071863A1 (en) * 1999-12-09 2002-06-13 Dong Liang C. Antiviral medication
US7011850B2 (en) 1999-12-16 2006-03-14 Alza Corporation Dosage forms having a barrier layer to laser ablation
US20050220879A1 (en) * 1999-12-16 2005-10-06 Alza Corporation Dosage forms having a barrier layer to laser ablation
US6379498B1 (en) 2000-02-28 2002-04-30 Kimberly-Clark Worldwide, Inc. Method for adding an adsorbable chemical additive to pulp during the pulp processing and products made by said method
US6740406B2 (en) 2000-12-15 2004-05-25 Kimberly-Clark Worldwide, Inc. Coated activated carbon
US20100243187A1 (en) * 2001-03-07 2010-09-30 Troy Michael Runge Method for Applying Chemical Additives to Pulp During the Pulp Processing and Products Made by Said Method
US7749356B2 (en) 2001-03-07 2010-07-06 Kimberly-Clark Worldwide, Inc. Method for using water insoluble chemical additives with pulp and products made by said method
US7993490B2 (en) 2001-03-07 2011-08-09 Kimberly-Clark Worldwide, Inc. Method for applying chemical additives to pulp during the pulp processing and products made by said method
US6582560B2 (en) 2001-03-07 2003-06-24 Kimberly-Clark Worldwide, Inc. Method for using water insoluble chemical additives with pulp and products made by said method
US6984290B2 (en) 2001-03-07 2006-01-10 Kimberly-Clark Worldwide, Inc. Method for applying water insoluble chemical additives with to pulp fiber
US20030159786A1 (en) * 2001-03-07 2003-08-28 Runge Troy Michael Method for using water insoluble chemical additives with pulp and products made by said method
US7625201B2 (en) 2001-08-06 2009-12-01 Southwest Research Institute Method and apparatus for testing catalytic converter durability
US20080070169A1 (en) * 2001-08-06 2008-03-20 Ingalls Melvin N Method and apparatus for testing catalytic converter durability
US7140874B2 (en) 2001-08-06 2006-11-28 Southwest Research Institute Method and apparatus for testing catalytic converter durability
US6881482B2 (en) 2001-08-16 2005-04-19 Southwest Research Institute Microencapsulation using electromagnetic energy and core and shell materials with different dielectric constants and dissipation factors
US20030062641A1 (en) * 2001-08-16 2003-04-03 Niraj Vasishtha Microencapsulation using electromagnetic energy and core and shell materials with different dielectric constants and dissipation factors
US20070207204A1 (en) * 2001-12-18 2007-09-06 Alza Corporation Dosage Form for Time-Varying Patterns of Drug Delivery
US20030125714A1 (en) * 2001-12-18 2003-07-03 Edgren David Emil Dosage form for time-varying patterns of drug delivery
US6852904B2 (en) 2001-12-18 2005-02-08 Kimberly-Clark Worldwide, Inc. Cellulose fibers treated with acidic odor control agents
US6767553B2 (en) 2001-12-18 2004-07-27 Kimberly-Clark Worldwide, Inc. Natural fibers treated with acidic odor control/binder systems
US20030232078A1 (en) * 2001-12-19 2003-12-18 Dong Liang C. Formulation & dosage form for the controlled delivery of therapeutic agents
US20030198619A1 (en) * 2001-12-19 2003-10-23 Dong Liang C. Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
US6685775B1 (en) 2002-02-19 2004-02-03 Vector Corporation Wurster air diverter
US20030165614A1 (en) * 2002-03-01 2003-09-04 Henrik Hansen Coating a medical implant using a pan coater
US20040010000A1 (en) * 2002-04-29 2004-01-15 Ayer Atul D. Methods and dosage forms for controlled delivery of oxycodone
US20050106249A1 (en) * 2002-04-29 2005-05-19 Stephen Hwang Once-a-day, oral, controlled-release, oxycodone dosage forms
US20030224051A1 (en) * 2002-05-31 2003-12-04 Fink Tracy A. Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone
US20040091529A1 (en) * 2002-06-26 2004-05-13 David Edgren Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
US9393192B2 (en) 2002-07-29 2016-07-19 Alza Corporation Methods and dosage forms for controlled delivery of paliperidone and risperidone
US20040115262A1 (en) * 2002-07-29 2004-06-17 Frank Jao Formulations and dosage forms for controlled delivery of topiramate
US20050232995A1 (en) * 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US20040115315A1 (en) * 2002-08-02 2004-06-17 Camelot Damien Michel Andre Encapsulated crystalline lactic acid
US7687092B2 (en) 2002-08-02 2010-03-30 Purac Biochem B.V. Encapsulated crystalline lactic acid
US20040045687A1 (en) * 2002-09-11 2004-03-11 Shannon Thomas Gerard Method for using water insoluble chemical additives with pulp and products made by said method
US9233160B2 (en) 2002-12-13 2016-01-12 Durect Corporation Oral drug delivery system
US9517271B2 (en) 2002-12-13 2016-12-13 Durect Corporation Oral drug delivery system
US8420120B2 (en) 2002-12-13 2013-04-16 Durect Corporation Oral drug delivery system
US8354124B2 (en) 2002-12-13 2013-01-15 Durect Corporation Oral drug delivery system
US7259186B2 (en) 2002-12-17 2007-08-21 Abbott Laboratories Salts of fenofibric acid and pharmaceutical formulations thereof
US20060134196A1 (en) * 2002-12-17 2006-06-22 Abbott Gmbh & Co. Kg Formulation comprising fenofibric acid, a physiologically acceptable salt or derivative thereof
US20050148594A1 (en) * 2002-12-17 2005-07-07 Cink Russell D. Salts of fenofibric acid and pharmaceutical formulations thereof
US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
US20040166160A1 (en) * 2003-01-14 2004-08-26 Ramkumar Subramanian Methods and dosage forms with modified viscosity layers
US20040197407A1 (en) * 2003-02-11 2004-10-07 Ramkumar Subramanian Methods and dosage forms with modified layer geometry
US8039048B2 (en) 2003-06-20 2011-10-18 Certainteed Corporation Algae resistant roofing granules with controlled algaecide leaching rates, algae resistant shingles and process for producing same
US8668954B2 (en) 2003-06-20 2014-03-11 Certainteed Corporation Algae resistant roofing granules with controlled algaecide leaching rates, algae resistant shingles and process for producing same
US20100047524A1 (en) * 2003-06-20 2010-02-25 Hong Keith C Algae resistant roofing granules with controlled algaecide leaching rates, algae resistant shingles and process for producing same
US20110217515A1 (en) * 2003-06-20 2011-09-08 Hong Keith C Algae resistant roofing granules with controlled algaecide leaching rates, algae resistant shingles and process for producing same
US20050058707A1 (en) * 2003-08-06 2005-03-17 Iran Reyes Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
US20050136108A1 (en) * 2003-08-22 2005-06-23 Yam Noymi V. Stepwise delivery of topiramate over prolonged period of time
US20050069587A1 (en) * 2003-09-02 2005-03-31 Modi Nishit Bachulal Novel drug compositions and dosage forms of topiramate
US20050158382A1 (en) * 2003-09-26 2005-07-21 Evangeline Cruz Controlled release formulations of opioid and nonopioid analgesics
US20050089570A1 (en) * 2003-09-26 2005-04-28 Evangeline Cruz Oros push-stick for controlled delivery of active agents
US8246986B2 (en) 2003-09-26 2012-08-21 Alza Corporation Drug coating providing high drug loading
US20050112195A1 (en) * 2003-09-26 2005-05-26 Evangeline Cruz Drug coating providing high drug loading and methods for providing same
US20060251721A1 (en) * 2003-09-26 2006-11-09 Evangeline Cruz Controlled release formulations of opioid and nonopioid analgesics
US8226979B2 (en) 2003-09-26 2012-07-24 Alza Corporation Drug coating providing high drug loading and methods for providing the same
US20050169992A1 (en) * 2003-12-23 2005-08-04 Frank Jao Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
US20050175690A1 (en) * 2003-12-29 2005-08-11 David Edgren Novel drug compositions and dosage forms
US20050175697A1 (en) * 2003-12-29 2005-08-11 David Edgren Novel drug compositions and dosage forms of topiramate
US20060009425A1 (en) * 2004-05-28 2006-01-12 Leticia Delgado-Herrera Oral formulations of paricalcitol
US20050287212A1 (en) * 2004-06-28 2005-12-29 Liang-Chang Dong Oral delivery system comprising a drug/polymer complex
US20050287213A1 (en) * 2004-06-28 2005-12-29 Wong Patrick S Dosage forms for low solubility and or low dissolution rate free acid pharmaceutical agents
US20060057206A1 (en) * 2004-08-19 2006-03-16 Wong Patrick S Controlled release nanoparticle active agent formulation dosage forms and methods
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070281018A1 (en) * 2004-09-24 2007-12-06 Abbott Laboratories Sustained release formulations of opioid and nonopioid analgesics
WO2006061576A1 (en) * 2004-12-11 2006-06-15 Apv Systems Limited Food item coating apparatus and method
US20060153889A1 (en) * 2005-01-10 2006-07-13 Friel Francis M Discontinuous surface coating for particles
US20110237675A1 (en) * 2005-04-08 2011-09-29 Abbott Laboratories Pharmaceutical formulations
EP2074992A1 (en) 2005-04-08 2009-07-01 Abbott Laboratories Pharmaceutical formulations
US20080152714A1 (en) * 2005-04-08 2008-06-26 Yi Gao Pharmaceutical Formulations
US20060251807A1 (en) * 2005-05-06 2006-11-09 Hong Keith C Roofing Granules With Improved Surface Coating Coverage And Functionalities And Method For Producing Same
US20070003624A1 (en) * 2005-06-29 2007-01-04 Shanbhag Anant R Semi-permeable compositions providing reduced drying time for osmotic dosage forms
US20070031496A1 (en) * 2005-08-04 2007-02-08 Edgren David E Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties
US20070190137A1 (en) * 2005-10-07 2007-08-16 Reyes Iran Osmotic dosage form with controlled release and fast release aspects
US20090221621A1 (en) * 2005-10-31 2009-09-03 Alza Corporation Methods of Reducing Alcohol-Induced Dose Dumping for Opioid Sustained Release Oral Dosage Forms
WO2007053698A2 (en) 2005-10-31 2007-05-10 Alza Corporation Methods of reducing alcohol-induced dose dumping for opioid sustained release oral dosage forms
US20070148342A1 (en) * 2005-12-23 2007-06-28 Kalkanoglu Husnu M Controlled time-release algae resistant roofing system
US20090317355A1 (en) * 2006-01-21 2009-12-24 Abbott Gmbh & Co. Kg, Abuse resistant melt extruded formulation having reduced alcohol interaction
US20100172989A1 (en) * 2006-01-21 2010-07-08 Abbott Laboratories Abuse resistant melt extruded formulation having reduced alcohol interaction
US8703193B2 (en) * 2006-10-16 2014-04-22 Cosci Med-Tech Co. Ltd. Controlled porous osmotic pump tablets of high permeable drugs and the preparation process thereof
US20100291208A1 (en) * 2006-10-16 2010-11-18 Jingang Wang Controlled porous osmotic pump tablets of high permeable drugs and the preparation process thereof
US20080214629A1 (en) * 2007-02-09 2008-09-04 Scott Bull Controlled release compositions of tizanidine
US8524749B2 (en) 2007-02-09 2013-09-03 Alza Corporation Controlled release compositions of tizanidine
US20090022798A1 (en) * 2007-07-20 2009-01-22 Abbott Gmbh & Co. Kg Formulations of nonopioid and confined opioid analgesics
US9024009B2 (en) 2007-09-10 2015-05-05 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20090233874A1 (en) * 2007-09-10 2009-09-17 Abdel-Magid Ahmed F Process for the preparation of compounds useful as inhibitors of sglt
US20090087484A1 (en) * 2007-09-28 2009-04-02 Alza Corporation Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
US9592204B2 (en) 2007-12-06 2017-03-14 Durect Corporation Oral pharmaceutical dosage forms
US9655861B2 (en) 2007-12-06 2017-05-23 Durect Corporation Oral pharmaceutical dosage forms
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20100099883A1 (en) * 2008-10-17 2010-04-22 Walter Ferdinand Maria Fillers Process for the preparation of compounds useful as inhibitors of sglt
US9616055B2 (en) 2008-11-03 2017-04-11 Durect Corporation Oral pharmaceutical dosage forms
US20100189878A1 (en) * 2009-01-26 2010-07-29 Teva Pharmaceutical Industries Ltd. Processes for coating a carrier with microparticles
US8889213B2 (en) 2009-01-26 2014-11-18 Teva Pharmaceutical Industries Ltd. Processes for coating a carrier with microparticles
WO2010085780A1 (en) 2009-01-26 2010-07-29 Teva Pharmaceutical Industries Ltd. Processes for coating a carrier with microparticles
US20110009347A1 (en) * 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
WO2011005811A1 (en) 2009-07-08 2011-01-13 Janssen Pharmaceutical Nv Combination therapy for the treatment of diabetes
US8772512B2 (en) 2009-07-10 2014-07-08 Janssen Pharmaceutica Nv Crystallisation process for 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene
EP2306792A3 (en) * 2009-09-24 2013-04-17 Fachhochschule Hildesheim / Holzminden / Göttingen Method and device for handling objects with a physical plasma at atmospheric pressure
US20110087017A1 (en) * 2009-10-14 2011-04-14 Vittorio Farina Process for the preparation of compounds useful as inhibitors of sglt2
US9174971B2 (en) 2009-10-14 2015-11-03 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
US9540822B2 (en) 2009-11-24 2017-01-10 Certainteed Corporation Composite nanoparticles for roofing granules, roofing shingles containing such granules, and process for producing same
US20110159240A1 (en) * 2009-11-24 2011-06-30 Ming Liang Shiao Composite nanoparticles for roofing granules, roofing shingles containing such granules, and process for producing same
WO2011143296A1 (en) 2010-05-11 2011-11-17 Janssen Pharmaceutica Nv Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt
WO2012006298A2 (en) 2010-07-06 2012-01-12 Janssen Pharmaceutica Nv Formulation for co-therapy treatment of diabetes
US9035044B2 (en) 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
US9345623B2 (en) 2011-08-09 2016-05-24 Biomet Biologics, Llc Surgical mesh spray and delivery system
US8776716B2 (en) * 2011-08-09 2014-07-15 Biomet Biologics, Llc Surgical mesh spray and delivery system
US20130040042A1 (en) * 2011-08-09 2013-02-14 Biomet Biologics, Llc Surgical Mesh Spray and Delivery System
US9572885B2 (en) 2013-03-15 2017-02-21 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US9855333B2 (en) 2013-03-15 2018-01-02 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US9555113B2 (en) 2013-03-15 2017-01-31 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
WO2014179453A1 (en) 2013-04-30 2014-11-06 Abbvie, Inc. Methods for improving lipid profiles using atrasentan

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