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US2764157A - Ampules - Google Patents

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Publication number
US2764157A
US2764157A US39554253A US2764157A US 2764157 A US2764157 A US 2764157A US 39554253 A US39554253 A US 39554253A US 2764157 A US2764157 A US 2764157A
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US
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Grant
Patent type
Prior art keywords
material
container
solution
portion
powdered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Oliva Juan Fernandez
Simon Felix Fernandez
Original Assignee
Oliva Juan Fernandez
Simon Felix Fernandez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02Internal fittings
    • B65D25/04Partitions
    • B65D25/08Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents
    • B65D25/085Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents the partition being in the form of a plug or the like which is dislodged by means of a plunger rod or the like pushing the plug down
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06Ampoules or carpules
    • A61J1/065Rigid ampoules, e.g. glass ampoules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202Separating means
    • A61J1/2037Separating means having valve means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202Separating means
    • A61J1/2041Separating means having removable plugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093Containers having several compartments for products to be mixed

Description

Sept. 25, 1956 J. F. OLIVA ET AL AMPULEIS Filed Dec. l, 1955 United States Patent Office AMPULES Juan Fernandez Oliva and Felix Fernandez Simon, Havana, Cuba Application December 1, 1953, Serial No. 395,542 1 Claim. (Cl. 12S-272) This invention relates to containers and more particularly, to containers or ampules of the type commonly employed to till hypodermic syringes.

In such ampules or containers currently in use, the ampule or container is lled after the powdered material has been dissolved in the desired solution, whereupon the solution may then later be extracted by the hypodermic syringe by puncturing the container cover. Such containers wherein the powdered material is already dissolved in the desired solution are objectionable in that deterioration and decomposition of the material occur on standing.

It is accordingly a principal object of the present invention to provide a container or ampule adapted to be easily fand readily used to till hypodermic syringes wherein the powdered material is sealed oft" from the solution until such time as it is desired to employ the contents of the container, just prior to filling lthe hypodermic syringe, whereupon the contents are permitted to mix in a novel manner.

It is another object of the present invention to provide a container or ampule of the type commonly employed to fill hypodermic syringes wherein the powdered material is sealed off from the solution, the powdered material being permitted to dissolve in the liquid by simply pressing a exible cover which also serves to later receive therethrough the needle of the hypodermic syringe.

Other objects of the present invention are to provide a container or ampule bearing the above objects in mind which is of simple construction, inexpensive to manufacture, has a minimum number of parts, is easy to use and etlicient in operation.

For other objects and a better understanding of the invention, reference may be had to the following detailed description taken in connection with the accompanying drawing in which:

Figure l is a perspective view of a container or ampule embodying the features of the present invention and shown prior to the dissolving of the powdered material in the solution;

Figure 2 is an enlarged longitudinal sectional view taken along the line 2--2 of Figure 1;

Figure 3 is an enlarged side view, shown partly in sec tion and partly in elevation, and showing the manner in which the powdered material is dissolved in the liquid solution just prior to puncturing with the hypodermic needle;

Figure 4 is a view similar to Figure l but showing the container after the powdered material has been permitted to dissolve in a solution, shown partly broken away; and

Figure S is a perspective view showing the invention being employed to fill a hypodermic syringe.

Referring now more in detail to the drawing, wherein similar reference numerals identify corresponding parts throughout the several views, represents an elongated hollow cylinder of glass or other suitable material having a bottom end wall 11 and an outwardly ared or rimmed open top end 12, substantially as illustrated.

2,764,157 Patented Sept. 25, 1956 The cylinder 10 intermediate its ends is provided with a restricted portion 13 which serves to retain a rubber piston 14 against downward displacement therethrough, the latter dividing the cylinder into an upper compartment 15 and a lower compartment 16. The piston 14 is provided with a central opening 17 for a purpose which will hereinafter become clear.

The container 10 is rst tilled with the powdered material 1S, for example penicillin, after which the piston 14 is then inserted and moved downwardly until it abuts the restricted portion 13.

An elongated rod 19 of glass or other suitable material is integrally formed at its lower end with an enlarged cylindrical plug 20 adapted to be forced into the central opening 17 of rubber piston 14 and providing a closure therefor. The upper end of rod 19 extends `above the open end 12 and is formed with an enlarged knob 21 for a purpose which will hereinafter become clear.

After the plug 20 of rod 19 is forced into piston 14, whereby to close the central opening 17 of the latter and to seal off the lower compartment 16 from the upper compartment 15, the liquid, for example saline solution 22, is poured into the container up to the enlarged mouth 12 (Figure 2).

A convex cover 23 of rubber or other elastic, flexible material and having a flanged portion 24 is stretched and then snapped over the open mouth 12 (Figure 2) and secured in place by means of a plastic seal 25. It will be noted that the knob 21 of rod 19 is disposed within and adjacent to the convex cover 23. It will also be noted that the solution or liquid 22 is sealed oi from the powdered material 18, preventing their mixing and subsequent decomposition during prolonged standing or storage.

The container or ampule is now ready for shipment, marketing and ultimate distribution to .hospitals or physicians, and may be stored indefinitely without decomposition or deterioration.

When it is desired to use the contents of the container, it is only necessary to press the convex cover 23 downwardly, as shown in Figure 3, which brings the cover 23 into contact with the knob 21 of rod 19 and forces the latter downwardly, pushing the plug 20 downwardly through piston 14. The liquid 22 will then pass downwardly through opening 17 into the lower compartment 16 where it dissolves the powdered material 18 to form the solution 26. The hypodermic syringe 27 (Figure 5) may then be lled with this freshly prepared solution 26 by inserting the hypodermic needle 28 through the cover 23 and drawing the plunger 29 upwardly in the usual manner, providing a syringe iilled with a freshly prepared solution 26 of maximum potency, regardless of the period during which the ampule or container was stored.

While the cylinder 10 and rod 19 have been described as being formed of glass, it will be readily apparent to those skilled in the fart that these parts may be formed of aluminum, plastic or any other suitable material. It will also be apparent to those skilled in the art that while the container or ampule has been described in connection with a hypodermic syringe, it will be readily appreciated that the construction may be employed wherever it is desired to store two separate and different substances without mixing until they are ready to be used.

While various changes may be made in the detail construction, it shall be understood that such changes shall be within the spirit and scope of the present invention, as defined by the .appended claim.

We claim:

A container comprising a hollow body portion closed at one end, and open at the other, said body portion having a restricted portion intermediate the ends thereof,

a closure within said body portion and in abutment with the side of said restricted portion remote from said closed end, said closure having a central opening, a plug press tted Within said central opening whereby to close the same and to permit powdered material to be disposed intermediate said closure and the closed end of said body portion and liquid material intermediate said closure and the open end of said body portion without `admixture, an elongated rod connected to said plug and extending upwardly through the open end of said body portion, and a eXible cover sealing the open end of said body portion, the upper end of said rod terminating within and near said flexible cover.

References Cited in the file of this patent UNITED STATES PATENTS Casey Oct. 30, Greenberg Oct. 3l, Smith Sept. 29, Brown Jan. 12, Lockhart Sept. 2l,

US2764157A 1953-12-01 1953-12-01 Ampules Expired - Lifetime US2764157A (en)

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Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3467097A (en) * 1965-07-06 1969-09-16 V O M Corp Dual medicinal vial
US3990683A (en) * 1974-12-24 1976-11-09 Reichhold Chemicals, Inc. Packaging means
US4020832A (en) * 1974-12-24 1977-05-03 Reichhold Chemicals, Inc. Package and method for preparing orthopedic cast-making materials
US4315570A (en) * 1979-01-04 1982-02-16 Jules Silver Two-compartment container with means for dispersing contents of one compartment into the other compartment
US4453636A (en) * 1983-05-03 1984-06-12 Meadows Bernard A Safe container
US4950237A (en) * 1987-11-06 1990-08-21 Merck & Co., Inc. Dual chambered mixing and dispensing vial
US5110215A (en) * 1990-12-21 1992-05-05 Temple University Container for liquid crystal cumulative dosimeter
US5149320A (en) * 1988-04-11 1992-09-22 Dhaliwal Avtar S Composite anesthetic article and method of use
US5158364A (en) * 1990-12-21 1992-10-27 Temple University Method of making and using an improved liquid crystal cumulative dosimeter container
US5226878A (en) * 1992-01-10 1993-07-13 Whitaker Designs, Inc. Two-container system for mixing medicament with diluent including safety wand to protect against improper titration
US5335773A (en) * 1993-07-02 1994-08-09 Habley Medical Technology Corporation Multi-pharmaceutical storage, mixing and dispensing vial
WO1995001285A1 (en) * 1993-07-02 1995-01-12 Habley Medical Technology Corporation Multi-pharmaceutical storage, mixing and dispensing vial
US5423791A (en) * 1992-03-31 1995-06-13 Bartlett; J. Mark Valve device for medical fluid transfer
US5634714A (en) * 1995-06-28 1997-06-03 Guild; William Fluid mixing and dispensing system for the rapid mixing of a prestored substance with a fluid and the dispensing thereof
FR2767514A1 (en) * 1997-08-22 1999-02-26 Dominique Mounier Container for mixing two part compounds just prior to injection by syringe
US20030026164A1 (en) * 2001-08-02 2003-02-06 Klein Arnold Gregory Convenience nectar mixing and storage devices
US20050070873A1 (en) * 1995-10-10 2005-03-31 The Compak Companies, Llc Constituent delivery system
DE102004021990B3 (en) * 2004-05-04 2005-11-10 Fresenius Kabi Deutschland Gmbh Medical container for administering a liquid consisting of a carrier solution and a medicament comprises a chamber provided with means for delivery of the medicament into the chamber holding the carrier solution
US20060153000A1 (en) * 2001-08-02 2006-07-13 Klein Arnold G Convenience nectar mixing and storage devices
US20100025268A1 (en) * 2005-12-19 2010-02-04 Lee Jeong-Min Pressurization type cap assembly having storage chamber for secondary material
US20100054075A1 (en) * 2008-09-02 2010-03-04 Cook Incorporated Vertebroplasty all in one mixer
EP2236431A1 (en) * 2009-03-26 2010-10-06 Inova Packaging device
US20110000800A1 (en) * 2009-02-11 2011-01-06 Robert Dale Rohr Inverted dome to supply dose
US20120193362A1 (en) * 2011-02-01 2012-08-02 Granite State Product Development LLC Dispensing cap for a container
US20120275258A1 (en) * 2011-04-27 2012-11-01 Doron Rigel Mixing tumbler
CN102846469A (en) * 2011-06-29 2013-01-02 吴振文 Multi-dosage-form medicament bottle
US20130018352A1 (en) * 2011-07-12 2013-01-17 Kuo-Cheng Wu Multi-Medicament Container
CN102920599A (en) * 2011-08-08 2013-02-13 吴振文 Compound type medicament bottle
US20130068771A1 (en) * 2011-09-21 2013-03-21 David Tong Multi-Dye Container
US9650175B2 (en) * 2011-08-12 2017-05-16 Kuo-Cheng Wu Container

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2387978A (en) * 1943-07-30 1945-10-30 Terrance B Casey Closure for vessels
US2527992A (en) * 1947-11-21 1950-10-31 Alvin A Greenberg Capsule
US2653610A (en) * 1950-10-28 1953-09-29 Arthur E Smith Dispensing closure
US2665687A (en) * 1950-08-02 1954-01-12 Frederick M Turnbull Syringe assembly
US2689566A (en) * 1951-09-28 1954-09-21 Compule Corp Plural-compartment admixing vial for segregated storage of ingredients of solutions and liquid mixtures

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2387978A (en) * 1943-07-30 1945-10-30 Terrance B Casey Closure for vessels
US2527992A (en) * 1947-11-21 1950-10-31 Alvin A Greenberg Capsule
US2665687A (en) * 1950-08-02 1954-01-12 Frederick M Turnbull Syringe assembly
US2653610A (en) * 1950-10-28 1953-09-29 Arthur E Smith Dispensing closure
US2689566A (en) * 1951-09-28 1954-09-21 Compule Corp Plural-compartment admixing vial for segregated storage of ingredients of solutions and liquid mixtures

Cited By (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3467097A (en) * 1965-07-06 1969-09-16 V O M Corp Dual medicinal vial
US3990683A (en) * 1974-12-24 1976-11-09 Reichhold Chemicals, Inc. Packaging means
US4020832A (en) * 1974-12-24 1977-05-03 Reichhold Chemicals, Inc. Package and method for preparing orthopedic cast-making materials
US4315570A (en) * 1979-01-04 1982-02-16 Jules Silver Two-compartment container with means for dispersing contents of one compartment into the other compartment
US4453636A (en) * 1983-05-03 1984-06-12 Meadows Bernard A Safe container
US4950237A (en) * 1987-11-06 1990-08-21 Merck & Co., Inc. Dual chambered mixing and dispensing vial
US5149320A (en) * 1988-04-11 1992-09-22 Dhaliwal Avtar S Composite anesthetic article and method of use
US5110215A (en) * 1990-12-21 1992-05-05 Temple University Container for liquid crystal cumulative dosimeter
WO1992011519A1 (en) * 1990-12-21 1992-07-09 Temple University - Of The Commonwealth System Of Higher Education Improved container for liquid crystal cumulative dosimeter
US5158364A (en) * 1990-12-21 1992-10-27 Temple University Method of making and using an improved liquid crystal cumulative dosimeter container
US5226878A (en) * 1992-01-10 1993-07-13 Whitaker Designs, Inc. Two-container system for mixing medicament with diluent including safety wand to protect against improper titration
US5423791A (en) * 1992-03-31 1995-06-13 Bartlett; J. Mark Valve device for medical fluid transfer
WO1995001285A1 (en) * 1993-07-02 1995-01-12 Habley Medical Technology Corporation Multi-pharmaceutical storage, mixing and dispensing vial
US5593028A (en) * 1993-07-02 1997-01-14 Habley Medical Technology Corporation Multi-pharmaceutical storage, mixing and dispensing vial
US5335773A (en) * 1993-07-02 1994-08-09 Habley Medical Technology Corporation Multi-pharmaceutical storage, mixing and dispensing vial
US5634714A (en) * 1995-06-28 1997-06-03 Guild; William Fluid mixing and dispensing system for the rapid mixing of a prestored substance with a fluid and the dispensing thereof
US20050070873A1 (en) * 1995-10-10 2005-03-31 The Compak Companies, Llc Constituent delivery system
FR2767514A1 (en) * 1997-08-22 1999-02-26 Dominique Mounier Container for mixing two part compounds just prior to injection by syringe
WO1999010245A1 (en) * 1997-08-22 1999-03-04 Dominique Mounier Mixing flask contacting two isolated constituents before they are drawn and injected into a syringe
US20030026164A1 (en) * 2001-08-02 2003-02-06 Klein Arnold Gregory Convenience nectar mixing and storage devices
US8147119B2 (en) * 2001-08-02 2012-04-03 Arnold Gregory Klein Convenience nectar mixing and storage devices
US20060153000A1 (en) * 2001-08-02 2006-07-13 Klein Arnold G Convenience nectar mixing and storage devices
US8197116B2 (en) * 2001-08-02 2012-06-12 Klein Arnold G Convenience nectar mixing and storage devices
DE102004021990B3 (en) * 2004-05-04 2005-11-10 Fresenius Kabi Deutschland Gmbh Medical container for administering a liquid consisting of a carrier solution and a medicament comprises a chamber provided with means for delivery of the medicament into the chamber holding the carrier solution
US8413802B2 (en) * 2005-12-19 2013-04-09 Jeong-min Lee Pressurization type cap assembly having storage chamber for secondary material
US20100025268A1 (en) * 2005-12-19 2010-02-04 Lee Jeong-Min Pressurization type cap assembly having storage chamber for secondary material
US8308731B2 (en) 2008-09-02 2012-11-13 Cook Medical Technologies Llc Vertebroplasty all in one mixer
US20100054075A1 (en) * 2008-09-02 2010-03-04 Cook Incorporated Vertebroplasty all in one mixer
US8490786B2 (en) * 2009-02-11 2013-07-23 Liquid Health Labs, Inc. Inverted dome to supply dose
US20110000800A1 (en) * 2009-02-11 2011-01-06 Robert Dale Rohr Inverted dome to supply dose
EP2236431A1 (en) * 2009-03-26 2010-10-06 Inova Packaging device
US20130140198A1 (en) * 2010-02-10 2013-06-06 Liquid Health Lams, Inc. Inverted Dome to Supply Dose
US8613372B2 (en) * 2011-02-01 2013-12-24 Granite State Product Development LLC Dispensing cap for a container
US20150028037A1 (en) * 2011-02-01 2015-01-29 Granite State Product Development LLC Dispensing cap for a container
US20120193362A1 (en) * 2011-02-01 2012-08-02 Granite State Product Development LLC Dispensing cap for a container
US9186637B2 (en) * 2011-04-27 2015-11-17 Doron Rigel Mixing tumbler
US20120275258A1 (en) * 2011-04-27 2012-11-01 Doron Rigel Mixing tumbler
CN102846469B (en) * 2011-06-29 2016-01-20 吴振文 Multiple dosage form Vial
CN102846469A (en) * 2011-06-29 2013-01-02 吴振文 Multi-dosage-form medicament bottle
US9707157B2 (en) * 2011-07-12 2017-07-18 Kuo-Cheng Wu Multi-medicament container
US20130018352A1 (en) * 2011-07-12 2013-01-17 Kuo-Cheng Wu Multi-Medicament Container
CN102920599A (en) * 2011-08-08 2013-02-13 吴振文 Compound type medicament bottle
CN102920599B (en) * 2011-08-08 2016-11-02 吴振文 Complex forms Vial
US9650175B2 (en) * 2011-08-12 2017-05-16 Kuo-Cheng Wu Container
US20130068771A1 (en) * 2011-09-21 2013-03-21 David Tong Multi-Dye Container

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