US2726896A - Nebulizer for producing aerosol mist - Google Patents

Nebulizer for producing aerosol mist Download PDF

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US2726896A
US2726896A US310660A US31066052A US2726896A US 2726896 A US2726896 A US 2726896A US 310660 A US310660 A US 310660A US 31066052 A US31066052 A US 31066052A US 2726896 A US2726896 A US 2726896A
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air
jet
liquid
nebulizer
tube
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Bain L Mckinnon
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/21General characteristics of the apparatus insensitive to tilting or inclination, e.g. spill-over prevention

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  • This present nebulizer is of the type employing a single jet system with appropriately formed separator-bathe or barrier disposed in the str e'am of the jet and arranged to direct any large particles of liquid back into the liquid reservoir so that the discharge from the nebulizer will be a true aerosol mist.
  • nebulizer which may be preferably constructed of a suitable molded plastic material and in which the various desirable functions are all provided for but the elements maliing possible the improved operation have to a large degree been formed as separable units which are made separately and then assembled intothe whole. This makes it possible to adapt my present nebulizer to produce sprays of diverse aerosol dispersion characteristics and hence suitable for different types of fluids and many specialized uses.
  • the principal object of present invention therefore is to provide a highly eflicient nebulizer so characterized by design features as to permit economical manufacture of a design which is adaptable to a wide range of achievement.
  • a further object of this invention is to provide a nebulizer in which the various intricate elements, especially those having fine passageways therethrough, can be made as separable units to the end that cleaning can be easily achieved and by changing the units a wide range of adaptability is provided.
  • a further object of this invention is to provide a definite arrangement between the air jet and the liquid supply tube and a variable arrangement of the separatorbafiie between the liquid supply tube and the outlet from the container so that a very line, or variable, to comparatively coarse aerosol can be produced from the device.
  • a further object of this invention is to provide an efiicient separator, as a baffie, barrier or impingement target, which will separate the larger droplets from the desired aerosol and yet not allow liquid to be blown from its surface through the outlet from the container.
  • a further object of this'invention' is to provide a means of regulation of the primary spray from the jet and to provide a means of filtering the solution to the liquid jet in order to prevent clogging of this jet.
  • a further object of this invention is to provide means which will insure against the leakage of fluid from the nebulizer to the end that the same may be carried about in the handbag or pocket of a person without danger of soiling articles or clothing with which the nebulizer may come in contact.
  • Figure 1 is a typical vertical cross-sectional view through a nebulizer wit the flexible bulb broken away, made after the teachings of my present invention
  • Figure 2 is a bracketed, exploded view showing in perspective and in section certain elements making up the air jet assembly
  • Figure 3 is a perspective view showing one form of liquid supply tube
  • Figure 4 is a perspective view showing a form of barrier or impingement target adapted for association with the construction of Figure 3;
  • Figure 5 is a perspective view illustrating the outside appearance of a nebulizer made after the teachings of this present invention
  • Figure 6 is a vertical cross-sectional view taken along the line 6-6 of Figure 1;
  • Figure 7 illustrates in a perspective view partially in section a modified form of the liquid supply tube and the barrier or impingement target associated therewith;
  • Figure 8 is an enlarged, vertical sectional view of the liquid supply tube and illustrating the throttling plug in place
  • Figure 9 is a perspective view of the throttling plug used in the liquid supply tube.
  • the numeral 10 designates the base unit of my nebulizer. It consists broadly of a cup-like molding to one end of which is attached the air valve and to the other end the enclosing cover 14-. Axially disposed within the base unit is the air jet assembly 16. This consists of an inwardly directed flange or nozzle-like unit 18, axially disposed with respect to which is the jet tube 2i). Tube 20 is secured to base unit It at one point as shown in Figure 6 at 22. The bore within jet tube 20 is preferably tapered so as to securely hold and position the valve seat member 24. On its inner end member 24 is provided with a tapering valve seat 26 in which is adapted to seat the valve 28.
  • valve 28 The possible forward travel of valve 28 is limited by a plurality of inwardly directed fins 30 occurring within the nozzle-like, reduced portion 32 of the jet tube 29.
  • the stem of valve 28 is considerably reduced in diameter from the bore of seat member 24 so that when pressure is applied to bulb 12 there is no restriction of the flow of air through the jet tube until the nozzle portion 32 is reached.
  • the bulb is released, after being squeezed, any air tending to be drawn back out of the enclosed portion of the nebulizer by the bulb action will be arrested by valve 28.
  • Bulb 12 is preferably a closed bulb and the air required for the refilling of the same after it has been squeezed in the operation of the nebulizer is introduced through an air passageway 34 in base it This passageway communicates with the jet tube at a point where the valve seat member 24 is slotted and thus provides an adequate channel for the air. With this arrangement however, it is necessary to provide a valve as 36 so that air will be forced through the jet tube and not back out through tube 34 when the bulb is squeezed. xExperience has proven that an inverted valve, as shown, is the most satisfactory. Valve 36 is provided with a conical seat in the removable valve seat member 38, which 'construction is Well illustrated in Figure l. The inward movement of valve 36 is arrested by a suitable abutment in the wall of base unit 10.
  • base unit Within what is normally the lower portion of base unit is a preferably dovetailed guideway. Adapted to be slidably secured in guideway 40 is the liquid supply tube slipper portion 42. This unit has complementary sides adapted to fully engage the sides of guideway 49. On the slipper portion 42 is the liquid supply tube proper 44 which is in turn provided with a tapered bore throughout'its length and has a discharge end normal to the bore. This bore 46 communicates with a channel 48 formed in the slipper portion 42 and this construction insures that liquid will be drawn from the recessed portion 50 of the base unit 10.
  • This portion of the base unit is normally the lowermost portion when the device is used, as normally the device is used in an inclined position and by the arrangements shown in Figures 1 and 3 it will be apparent, it is believed, as long as there is any reasonable amount of liquid within the the nebulizer, the device will be operable.
  • a toothed comb member 52 Formed as part, preferably, of supply tube 44 is a toothed comb member 52.
  • the teeth of this member are arranged to be tangent to an arc struck from a center shown by the recesses 54 which occur on each side of fin 55.
  • the bottomrnost tooth as 56 extends outwardly beyond the arc of the teeth to form a limit stop.
  • a device of this order may be called upon to dispense various types of liquids, it has been found desirable to provide one or more insertable throttling plugs 57 having a finned taper plug portion 58 and a stabilizing base 59; This provides an excellent means for controlling the flow of various liquids through the supply tube 44.
  • a small bevel cut is made in the tip of the liquid jet as at 61. This causes the spray to form along a straight line of shear tangent to the direction of air flow and the film of liquid asperated from the jet is thereby subjected to maximum force of shearing action by the air stream.
  • Such a bevel also acts as a deflector causing an area of increased turbulence to form just above the jet and in which the spray first formed at the shearing edge is further broken up. It has been found in practice that such a bevel may be made by a knife cut in the otherwise depth until optimum spray is achieved.
  • FIG. 4 is illustrated one of the preferred forms of barrier or impingement targets.
  • This unit is provided with a barrier 60, have a parabolical frontal area and an elongated lee area.
  • This form of barrier offers the practical minimum of resistance to air flow past its surface consistent with its function as an adjustable separator.
  • the barrier 60 is provided with intersecting grooves as at'62 and 64 cut on its outer surface and at their intersection a passageway through into the hollow interior of 60.
  • this structure allows the liquid to collect in the lee areas of the groovesand to contact liquid draining within the barrier unit 60 thus formingithree annular, ever changing chains of liquid fused together at their apexes.
  • This liquid structure is strong and because it is anchored to the barrier, prevents any liquid which,
  • the barrier member 72 is formed with conical frontal portion and elongated or ovate lee portion, and has an annular. groove in the lee of its greatest diameter and is provided with a supporting arm 74 which in turn is connected fixedly to tube 44. Openings are provided in arm 74 at 76. It should be noted that the form of barrier 72 approximates a cross-section of revolution of barrier 60, but so modified that an additional line of shear is formed by the base of the cone in order to give more complete dispersion. This form of barrier offers a minimum of resistance to air flow past its surface; forms an excellent separator and is particularly meritorious for very fine spray production.
  • cover 14 which is generally dome-like in form as in the showing in Figures 1 and 5. It is secured to 7 liquid and the amount remaining in the device or the amount which has been filled into the same. Cover 14 is provided with a discharge sleeve or nozzle portion 84. The inwardly extending section of sleeve 84 lying as it is in the lee of the barrier or separator 60 adds very materially to the proficiency of operation. For periods when the device is not in use a plug member 86 is provided which is secured to base unit 10 by some convenient means as by the ball chain 88. Sleeve 84 has. a fr'ustoconical shape tapering to a reduced diameter as it extends inwardly.
  • Plug member 86 is similarly shaped so as to form a locking seal when inserted into the sleeve under pressure. For this reason it isdesirable that the transverse wall be near the inner end of the plug substantially as illustrated in Figure 1.
  • the outer margin of the plug should have a reinforcing band of some considerable strength in order that the plug can be released when it is desired to use the device.
  • the angle of the conical sur-- face will be a function of the material used and will normally be somewhat less than a locking taper in metal.
  • Method of operation r jects a stream of airout through nozzle 30 past the upper st esses end of the liquid supply tube 44 and out through sleeve
  • the velocity of the air passing out through nozzle 32 is quite high and acting as a siphon or injector draws air from the outside through passageway 99 which is in free communication with the outside air as soon as bulb 12 is distorted.
  • the effect of this action is to first have a concentrated spray of liquid in a high velocity air stream passing out through nozzle 32, which is then diluted with the air that is drawn in through passage 90.
  • the air stream now laden with minute and some larger particles of liquid impinges upon the barrier 60 this acts as a separator and the air carrying the minute particles glides around the barrier and out sleeve 84.
  • Adjustment for variance of the dispersion characteristics of the aerosol is achieved by positioning the separator-barrier 64 upon the serrated arc 52. As the barrier is raised upon the arc the resultant aerosol produced becomes of finer dispersion, and when lowered to the extreme, the coarse spray of an atomizer results.
  • the barrier unit 60 When used as a coarse spray atomizer only, the barrier unit 60 may be detached from jet unit 42 and re moved. 1 Further adjustment of the spray, most particularly when used as an atomizer, may be achieved by removal or exchange of various throttling plugs 57. The greater the restn'ction offered by the throttling plug the finer the primary spray produced.
  • this nebulizer be supplied and marl;- eted complete with both exchangeable baffle systems as described. This is because one of the common uses, and the most exacting of all, is for the dispersion of epinephrine solutions for the treatment of asthma for which purpose an exceptionally fine dispersion is imperative and a bafiie separator of fixed characteristics may be demanded by many physicians because some users might not be entrusted to make the required adjustment for this purpose.
  • a device for producing aerosol mist adjustable to atomize and nebulize liquids therein comprising: walls defining a chamber having at one end an air ingress opening and having at its other end an air discharge opening; jet means connected to said air ingress opening and disposed to direct an air stream through said discharge opening; a liquid supply tube assembly having its discharge end disposed between said ingress and discharge openings; an impingement target having a pair of bowed arms secured at one end to said target, said arms being pivotally connected to said liquid supply tube assembly at their other end, said supply tube assembly having a toothed portion positioned adjacent said target, said toothed portion having an arc-shaped toothed surface with the center of the arc at the point of pivotal connection between said arms and said supply tube assembly, and said impingement target having a tooth engaging lug engaging said toothed surface permitting adjustment of said target at various positions in relation to a line between the centers of said ingress and discharge openings, afiording means for adjusting the fineness of disper- 6
  • a nebulizer comprising: a cup-like base unit with annular side walls and a base portion, said base portion having a central opening and an annular central flange bordering said central opening and disposed between said side wa l"' a dome-like cover disposed on said base unit n cer-engaging, sealing means between said side Walls or" said base unit and the corresponding portion of said cover, said cover having a discharge opening aligned with said central opening of said base unit; jet means including a resilient bulb connected to said central opening and disposed to direct an air stream through said discharge opening; a liquid supply tube having its discharge end disposed between said central and discharge openings and having its other end disposed near a side of said nebulizer to pick up liquid therein; an impingement target; a support for said impingement target, said support having adjustment means permitting positioning of said impingement target at various locations in relation to a line between the centers of said central and discharge openings, afiording means for adjusting the fineness 'of
  • a device for producing aerosol mist adjustable to atomize and nebulize liquids therein comprising: walls defining a chamber having at one end an air ingress opening and having at its other end an air discharge opening; jet means including a resilient bulb connected to said air ingress opening and disposed to direct an air stream through said discharge opening; a liquid supply tube having its discharge end disposed between said ingress and discharge openings; an impingement target having an inwardly facing dome shaped impingement surface; a support for said impingement target, and said support having adjustment means permitting manual adjustment of said support to locate said impingement target at various locations in relation to a line between the centers of said ingress and discharge openings by movement substantially laterally of said line, aifording means for adjusting the fineness of dispersion of liquid in the aerosol by changing the air-stream blocking location of said impingement surface from a location of minimum interference when the liquid is atomized to a location of maximum interference when the liquid is finely nebulized.
  • an air jet assembly comprising: walls forming a chamber including a base portion having a central opening therethrough; a jet tube positioned in said central opening and connected to said base portion by web means and partially blocking said central opening, means forming a liquid reservoir in said device and a liquid supply tube extending from the liquid reservoir to adjacent the discharge end of said jet 7 7 tube, said jet tube extending outside of said chamber and a resilient bulb positioned thereon, said base unit having annular flange means bordering and forming a circular line of contact with the outer surface of said bulb when the bulb is uncompressed and said flange means being of a size and positioned to permit passage of air between said bulb and said flange means and through said central op ening into said chamber when said bulb is compressed.
  • a nebulizer comprising: walls defining a chamber having at one end an air ingress opening and having at its other end an air discharge opening; jet means connected to said air ingress opening and disposed to direct an air stream through said discharge opening, said walls having means forming a dovetailed guideway and a liquid supply tube having its discharge end disposed between said ingress and discharge opening and having a slipper portion removably positioned in said guideway; an impingement target positioned between said ingress and discharge openings, said target being shaped in the form of two cones with their bases joined and with the'apex of one directed toward said air ingress opening and with the apex of the other directed toward said air discharge opening, and an arm connecting said target and said liquid supply tube for support of said target, said arm having an opening therethrough for anchoring of collected liquids on and arm.
  • a nebulizer comprising: a cup-like base with annular side walls and a bottom portion, a dome-like cover disposed on said base unit and interengaging, sealing threaded means between said annular side walls and the corresponding portion or" said cover, said cover having an air discharge opening therein, said base portion having jet air means including air pumping means attached thereto, means forming a dovetailed guideway on the inside surface of said annular side walls directed toward said bottom portion, a liquid supply tube having a liquid passageway and having a discharge end positioned adjacent said jet means and between the jet means and said air discharge opening, said liquid supply tube having at its other end a slipper portion extending obliquely therefrom and removably positioned in said dovetailed guideway securing the liquid supply tube in position, said slipper portion having a hollow, open bot- .tom for picking up liquid from said chamber, and a throttling plug similarly shaped to'said liquid supply tube and slipper portion and remov
  • a nebulizer comprising: a body having walls defining a chamber, one wall having jet air means including air pumping means attached thereto and anotherwall having an air discharge opening, a liquid supply tube having a liquid passageway and having a discharge end positioned adjacent said jet means and between the jet means and said air discharge opening, means on the inner surface of a wall of said body forming a dovetailed guideway and said liquid supply tube having at its other end a slipper portion removably positioned in said dovetailed guideway securing the liquid supply tube in position, said slipper portion having a hollow open wallabutting bottom for picking up liquid from said chamber, and a throttling plug similarly shaped to said liquid supply tube and slipper portion and removably positioned in said liquid passageway and said hollow bottom.
  • a device for producing an said target aerosol comprising: a body having walls defining acham her having an air discharge opening in one end and having extends from an adjacent wall of said body to said dis-.
  • a throttling plug positioned in said liquid, supply passageway near said adjacent wall and having a size to restrictthe effective size of said liquid supply passageway to control the amount of liquid passing from the liquid egress opening toethe discharge end of said liquid supply tube, and manually operable means in the nebulizer providing access to the location of said throttling plug in said liquid supply passageway permitting removal of the plug.
  • an impingement target is mounted in said chamber between said liquid supply tube and said air discharge opening in a manner permitting manual adjustment of position of the target relative a line between said air discharge opening and said jet nozzle so that said. target can be changed from a positionof minimum interference with the jet air stream when the liquid is atomized to a position of maximum interference when the liquid is finely nebulized.
  • a nebulizer comprising: a body having walls defining a chamber having an air discharge opening in one end, a jet nozzle positioned in the other end of said body and having air pumping means attached thereto, an impingement target mounted insaid body between said jet nozzle andsaid air discharge opening and in the path of the air stream from the nozzle, a liquid supply tube mounted in said body having a discharge end positioned adjacent said jet nozzle and between said jet nozzle and said impingement target-and in the path of the air stream from the nozzle with the longitudinal axis of the liquid supply tube extending laterally of the path of the air stream, said liquid supply tube having tubular walls forming a liquid supply passageway, the wall of the liquid supply tube at said discharge end on the side 7 toward said jet nozzle being beveled to adjacent the liquid passageway in the liquid supply tube in a plane forming an angle of approximately forty-five degrees to the path of travel of the air stream, the bevel forming aflat chordal surface in the air stream to subject liquid leaving said
  • a nebulizer comprising: a body having walls forming a chamber having an air discharge opening in one end and having a broad central air inlet opening at its other end; a jet tube positioned in said central opening and connected to the wall bordering the central opening by 'a web, the jet tube tapering as it extends toward the chamber and a resilient bulb positioned on the outer end of the jet tube; a tapered tube-like valve seat member, removably positioned in said jet tube, having an air passageway and an air jet valve having a valve stem of substantially smaller size than said air passageway radial fins acting as a stop limiting movement of the valve when it is moved to an open position by passage of air when the bulb is contacted; a liquid supply tubehaving a discharge end positioned adjacent the discharge end of said nozzle; and air-supply means by-passing said valve providing a source of air for said bulb during expansion of the 9 bulb, said air-supply means being adapted to close during contraction of the bulb.
  • a nebulizer comprising: a body having walls forming a chamber having an air discharge opening in one end and having a broad air inlet opening at its other end; a jet tube positioned in said inlet opening and connected to the wall bordering the inlet opening by a web, a resilient bulb positioned on the outer end of the jet tube; a liquid supply tube having a discharge end positioned adjacent the discharge end of said jet tube; a tube-like valve seat member, removably positioned in said jet tube, having an air jet passageway and an air jet valve having a valve stem of substantially smaller size than said air jet passageway slidably mounted therein and said valve having a valve head positioned at the chamber end of said jet tube and the valve head and jet tube having coacting surfaces operative to block said air jet passageway when the valve is moved to closed position by passage of air when the bulb is expanding, said body having an air supply passageway communicating with the outside of the chamber and extending laterally of the jet tube through said web to join the same at a point
  • said air supply passageway has a removable annular valve seat plug positioned in the outer end thereof, said one-way valve being positioned on the inside of said plug and having a valve stem positioned in said plug, the one-way valve and plug having opposed beveled annular surfaces to seal the same when the one-way valve is moved by passage of air when the bulb is contracted, the air supply passageway having a lateral oblique surface adjacent said one-way valve and the plug having limited adjustment longitudinally of the passageway whereby the oblique surface forms an adjustable stop for the one-way valve.
  • a body having walls forming a chamber having an air discharge opening in one end and having a jet air tube in the other end including a nozzle; a liquid supply tube having a discharge end positioned adjacent the discharge end of said nozzle; a resilient bulb connected to said jet air tube and a first one-way check valve positioned in jet air tube between the bulb and the nozzle operable by the passage of air therethrough to slide axially of said tube to seal said tube against passage of air when the bulb is expanding; air ingress means forming an air passageway to the outside of said chamber and a second one-way check valve positioned in the air passageway of the air ingress means at a point spaced from said jet tube, said air ingress means being positioned between said first one-way valve and said bulb and communicating with said bulb; said second one-way valve being operable by the passage of air through the air passageway of the air ingress means to slide axially of said passageway to seal the same against passage of air therethrough when the bulb
  • a device for producing aerosol mist adjustable to atomize and nebulize liquids therein comprising: Walls defining a chamber having at one end an air ingress opening and having at its other end an air discharge opening; jet means including a resilient bulb connected to said air ingress opening and disposed to direct an air stream through said discharge opening; a liquid supply tube having its discharge end disposed between said ingress and discharge openings; an impingement target; a support for said impingement target, and said support having adjustment means permitting adjustment of said support to locate said impingement target at various locations in relation to a line between the centers of said ingress and discharge openings, affording means for adjusting the fineness of dispersion of liquid in the aerosol by changing the air-stream blocking location of said target from a location of minimum interference when the liquid is atomized to a location of maximum interference when the liquid is finely nebulized, said target being hollow and having generally the shape of a paraboloid, said target having an opening at its top and having a groove running down its end away from

Description

Dec. 13, 1 B. MOKINNON NUBULIZER FOR PRODUCING AEROSOL MIST 2 Sheets-Sheet 1 Filed Sept. 20, 1952 MO KINNON L m A B 3nncntor (Ittornegs 1955 B. L. M KINNON NUBULIZER FOR PRODUCING AEROSOL MIST Zmventor Gttornegs 2 Sheets-Sheet 2 BAIN L. M KINNON Filed Sept. 20, 1952 United States Patent NEBULIZER non PiibDUCiNG AEROSOL MIST Bain L. McKinnon', Seattle, Wash. Application Se tember- 2d, 1952, senn No. 310,660
19 Claims. c1. 299 ss .s
This present nebulizer is of the type employing a single jet system with appropriately formed separator-bathe or barrier disposed in the str e'am of the jet and arranged to direct any large particles of liquid back into the liquid reservoir so that the discharge from the nebulizer will be a true aerosol mist.
in the construction of the present invention certain elements are employed which are in common with my United States Patent No. 2,586,845, issued February 26, 1952. This patent explains the presently accepted principles and theories that distinguish the nebulizer from the long known and used atomizer. This present invention is a highly developed nebulizer having embodied therein numerous details of structure not observed in any previous offerings in this field and which produce a nebulizer of unusually efficient design for the purpose intended and in which provision is made for wide variation of the degree of dispersion of the aerosol by simple adjustment of the separator-bafile. In the past various nebulizers have been produced which, though quite efficient in operation, were troublesome in use, for no adequate provision was made so that the small passageways could be kept clean. In my present design I have provided a highly efiicient nebulizer which may be preferably constructed of a suitable molded plastic material and in which the various desirable functions are all provided for but the elements maliing possible the improved operation have to a large degree been formed as separable units which are made separately and then assembled intothe whole. This makes it possible to adapt my present nebulizer to produce sprays of diverse aerosol dispersion characteristics and hence suitable for different types of fluids and many specialized uses.
The principal object of present invention therefore is to provide a highly eflicient nebulizer so characterized by design features as to permit economical manufacture of a design which is adaptable to a wide range of achievement.
A further object of this invention is to provide a nebulizer in which the various intricate elements, especially those having fine passageways therethrough, can be made as separable units to the end that cleaning can be easily achieved and by changing the units a wide range of adaptability is provided.
A further object of this invention is to provide a definite arrangement between the air jet and the liquid supply tube and a variable arrangement of the separatorbafiie between the liquid supply tube and the outlet from the container so that a very line, or variable, to comparatively coarse aerosol can be produced from the device.
A further object of this invention is to provide an efiicient separator, as a baffie, barrier or impingement target, which will separate the larger droplets from the desired aerosol and yet not allow liquid to be blown from its surface through the outlet from the container.
A further object of this'invention' is to provide a means of regulation of the primary spray from the jet and to provide a means of filtering the solution to the liquid jet in order to prevent clogging of this jet.
A further object of this invention is to provide means which will insure against the leakage of fluid from the nebulizer to the end that the same may be carried about in the handbag or pocket of a person without danger of soiling articles or clothing with which the nebulizer may come in contact.
Further objects, advantages and capabilities will be apparent from the description and disclosure in the drawings, or may be comprehended or are inherent in the device.
in the drawings:
Figure 1 is a typical vertical cross-sectional view through a nebulizer wit the flexible bulb broken away, made after the teachings of my present invention;
Figure 2 is a bracketed, exploded view showing in perspective and in section certain elements making up the air jet assembly;
Figure 3 is a perspective view showing one form of liquid supply tube;
Figure 4 is a perspective view showing a form of barrier or impingement target adapted for association with the construction of Figure 3;
Figure 5 is a perspective view illustrating the outside appearance of a nebulizer made after the teachings of this present invention;
Figure 6 is a vertical cross-sectional view taken along the line 6-6 of Figure 1;
Figure 7 illustrates in a perspective view partially in section a modified form of the liquid supply tube and the barrier or impingement target associated therewith;
Figure 8 is an enlarged, vertical sectional view of the liquid supply tube and illustrating the throttling plug in place;
Figure 9 is a perspective view of the throttling plug used in the liquid supply tube.
Referring more particularly to the disclosure in the drawings, the numeral 10 designates the base unit of my nebulizer. It consists broadly of a cup-like molding to one end of which is attached the air valve and to the other end the enclosing cover 14-. Axially disposed within the base unit is the air jet assembly 16. This consists of an inwardly directed flange or nozzle-like unit 18, axially disposed with respect to which is the jet tube 2i). Tube 20 is secured to base unit It at one point as shown in Figure 6 at 22. The bore within jet tube 20 is preferably tapered so as to securely hold and position the valve seat member 24. On its inner end member 24 is provided with a tapering valve seat 26 in which is adapted to seat the valve 28. The possible forward travel of valve 28 is limited by a plurality of inwardly directed fins 30 occurring within the nozzle-like, reduced portion 32 of the jet tube 29. The stem of valve 28 is considerably reduced in diameter from the bore of seat member 24 so that when pressure is applied to bulb 12 there is no restriction of the flow of air through the jet tube until the nozzle portion 32 is reached. On the other hand when the bulb is released, after being squeezed, any air tending to be drawn back out of the enclosed portion of the nebulizer by the bulb action will be arrested by valve 28. This prevents any possibility of liquid or riquid vapor from within the nebulizer chamber being drawn back into bulb 12, which of course would be objectionable on the grounds of possible deterioration of the material itself if left within the bulb, and the fact that certain liquids will cause deterioration of the bulb itself.
Bulb 12 is preferably a closed bulb and the air required for the refilling of the same after it has been squeezed in the operation of the nebulizer is introduced through an air passageway 34 in base it This passageway communicates with the jet tube at a point where the valve seat member 24 is slotted and thus provides an adequate channel for the air. With this arrangement however, it is necessary to provide a valve as 36 so that air will be forced through the jet tube and not back out through tube 34 when the bulb is squeezed. xExperience has proven that an inverted valve, as shown, is the most satisfactory. Valve 36 is provided with a conical seat in the removable valve seat member 38, which 'construction is Well illustrated in Figure l. The inward movement of valve 36 is arrested by a suitable abutment in the wall of base unit 10.
Within what is normally the lower portion of base unit is a preferably dovetailed guideway. Adapted to be slidably secured in guideway 40 is the liquid supply tube slipper portion 42. This unit has complementary sides adapted to fully engage the sides of guideway 49. On the slipper portion 42 is the liquid supply tube proper 44 which is in turn provided with a tapered bore throughout'its length and has a discharge end normal to the bore. This bore 46 communicates with a channel 48 formed in the slipper portion 42 and this construction insures that liquid will be drawn from the recessed portion 50 of the base unit 10. This portion of the base unit is normally the lowermost portion when the device is used, as normally the device is used in an inclined position and by the arrangements shown in Figures 1 and 3 it will be apparent, it is believed, as long as there is any reasonable amount of liquid within the the nebulizer, the device will be operable.
Formed as part, preferably, of supply tube 44 is a toothed comb member 52. The teeth of this member are arranged to be tangent to an arc struck from a center shown by the recesses 54 which occur on each side of fin 55. The bottomrnost tooth as 56 extends outwardly beyond the arc of the teeth to form a limit stop. As
a device of this order may be called upon to dispense various types of liquids, it has been found desirable to provide one or more insertable throttling plugs 57 having a finned taper plug portion 58 and a stabilizing base 59; This provides an excellent means for controlling the flow of various liquids through the supply tube 44.
In order to obtain maximum dispersion in the primary spray a small bevel cut is made in the tip of the liquid jet as at 61. This causes the spray to form along a straight line of shear tangent to the direction of air flow and the film of liquid asperated from the jet is thereby subjected to maximum force of shearing action by the air stream. Such a bevel also acts as a deflector causing an area of increased turbulence to form just above the jet and in which the spray first formed at the shearing edge is further broken up. It has been found in practice that such a bevel may be made by a knife cut in the otherwise depth until optimum spray is achieved.
In Figure 4 is illustrated one of the preferred forms of barrier or impingement targets. This unit is provided with a barrier 60, have a parabolical frontal area and an elongated lee area. This form of barrier offers the practical minimum of resistance to air flow past its surface consistent with its function as an adjustable separator. The barrier 60, is provided with intersecting grooves as at'62 and 64 cut on its outer surface and at their intersection a passageway through into the hollow interior of 60. When in use this structure allows the liquid to collect in the lee areas of the groovesand to contact liquid draining within the barrier unit 60 thus formingithree annular, ever changing chains of liquid fused together at their apexes. This liquid structure is strong and because it is anchored to the barrier, prevents any liquid which,
7 passing over the surface and having once made contact with it, from being blown from the barrier as droplets. Formed, preferably, as part ofthe unit are two arms 65 and 66. Each of these units is provided with a detent 63 which detents are established to operably engage the recesses 54 occurring on each side of fin of the liquid supply tube unit. Arms 65 and are provided with a bowed center portion so that they will fit over the liquid supply tube and disposed substantially between the two arms is the tooth engaging lug 69. This lug is adapted to engage the teeth of comb member 52 after the showing of Figure 1. In Figure 7 is illustrated a simplified form of liquid supply tube and barrier or impingement target. In this form a guide memberis'provided adapted to engage guideway 40. 'This guideway is provided with a channel similar to channel 48 and the liquid supply tube 44 is essentially the same as the preferred form. The barrier member 72 is formed with conical frontal portion and elongated or ovate lee portion, and has an annular. groove in the lee of its greatest diameter and is provided with a supporting arm 74 which in turn is connected fixedly to tube 44. Openings are provided in arm 74 at 76. It should be noted that the form of barrier 72 approximates a cross-section of revolution of barrier 60, but so modified that an additional line of shear is formed by the base of the cone in order to give more complete dispersion. This form of barrier offers a minimum of resistance to air flow past its surface; forms an excellent separator and is particularly meritorious for very fine spray production. When 'in use an annular chain of liquid forms in the lee area formed by the groove and this chain in further anchored by the draining liquid which collects on the supporting arm 74 and spaced through openings 76. This ever-changing liquid structure is strong 7 enough to prevent droplets from being blown from this type of barrier and allows for proper drainage down the supporting member.
An enclosure for the jet and associated parts is provided by cover 14 which is generally dome-like in form as in the showing in Figures 1 and 5. It is secured to 7 liquid and the amount remaining in the device or the amount which has been filled into the same. Cover 14 is provided with a discharge sleeve or nozzle portion 84. The inwardly extending section of sleeve 84 lying as it is in the lee of the barrier or separator 60 adds very materially to the proficiency of operation. For periods when the device is not in use a plug member 86 is provided which is secured to base unit 10 by some convenient means as by the ball chain 88. Sleeve 84 has. a fr'ustoconical shape tapering to a reduced diameter as it extends inwardly. Plug member 86 is similarly shaped so as to form a locking seal when inserted into the sleeve under pressure. For this reason it isdesirable that the transverse wall be near the inner end of the plug substantially as illustrated in Figure 1. The outer margin of the plug should have a reinforcing band of some considerable strength in order that the plug can be released when it is desired to use the device. The angle of the conical sur-- face will be a function of the material used and will normally be somewhat less than a locking taper in metal.
Method of operation r jects a stream of airout through nozzle 30 past the upper st esses end of the liquid supply tube 44 and out through sleeve The velocity of the air passing out through nozzle 32 is quite high and acting as a siphon or injector draws air from the outside through passageway 99 which is in free communication with the outside air as soon as bulb 12 is distorted. The effect of this action is to first have a concentrated spray of liquid in a high velocity air stream passing out through nozzle 32, which is then diluted with the air that is drawn in through passage 90. As the air stream now laden with minute and some larger particles of liquid impinges upon the barrier 60 this acts as a separator and the air carrying the minute particles glides around the barrier and out sleeve 84. The larger particles, however, impinge upon the surface of the barrier, whereupon the main portion is deflected therefrom to the sides of the container and the lesser portion adheres to the barrier and under the urgence of the air stream is carried upon that surface until one of the grooves 62 or 64 is encountered, whereupon it fuses with the liquid in these grooves and drains down by gravity into the main reservoir. The effect of the injected air, entering through passage 90, is to thoroughly remove from the chamber all of the fine aerosol produced therein, as the air supplied through the air jet from the rubber bulb is insufi'icient to do this efiectively.
Adjustment for variance of the dispersion characteristics of the aerosol is achieved by positioning the separator-barrier 64 upon the serrated arc 52. As the barrier is raised upon the arc the resultant aerosol produced becomes of finer dispersion, and when lowered to the extreme, the coarse spray of an atomizer results.
When used as a coarse spray atomizer only, the barrier unit 60 may be detached from jet unit 42 and re moved. 1 Further adjustment of the spray, most particularly when used as an atomizer, may be achieved by removal or exchange of various throttling plugs 57. The greater the restn'ction offered by the throttling plug the finer the primary spray produced.
it is intended that this nebulizer be supplied and marl;- eted complete with both exchangeable baffle systems as described. This is because one of the common uses, and the most exacting of all, is for the dispersion of epinephrine solutions for the treatment of asthma for which purpose an exceptionally fine dispersion is imperative and a bafiie separator of fixed characteristics may be demanded by many physicians because some users might not be entrusted to make the required adjustment for this purpose.
It is believed it will be clearly apparent from the above description and the disclosure in the drawings that the invention comprehends a novel construction of a nebulizer for producing aerosol mist.
Having thus disclosed the invention, 1 claim:
1. A device for producing aerosol mist adjustable to atomize and nebulize liquids therein, comprising: walls defining a chamber having at one end an air ingress opening and having at its other end an air discharge opening; jet means connected to said air ingress opening and disposed to direct an air stream through said discharge opening; a liquid supply tube assembly having its discharge end disposed between said ingress and discharge openings; an impingement target having a pair of bowed arms secured at one end to said target, said arms being pivotally connected to said liquid supply tube assembly at their other end, said supply tube assembly having a toothed portion positioned adjacent said target, said toothed portion having an arc-shaped toothed surface with the center of the arc at the point of pivotal connection between said arms and said supply tube assembly, and said impingement target having a tooth engaging lug engaging said toothed surface permitting adjustment of said target at various positions in relation to a line between the centers of said ingress and discharge openings, afiording means for adjusting the fineness of disper- 6 sion of liquid in the aerosol by changing the air-stream blocking position of said target from a positi on of minimum interference when the liquid is'atomized to a posie tion of maximum interference when the liquid is finely nebulized. v
2. A nebulizer, comprising: a cup-like base unit with annular side walls and a base portion, said base portion having a central opening and an annular central flange bordering said central opening and disposed between said side wa l"' a dome-like cover disposed on said base unit n cer-engaging, sealing means between said side Walls or" said base unit and the corresponding portion of said cover, said cover having a discharge opening aligned with said central opening of said base unit; jet means including a resilient bulb connected to said central opening and disposed to direct an air stream through said discharge opening; a liquid supply tube having its discharge end disposed between said central and discharge openings and having its other end disposed near a side of said nebulizer to pick up liquid therein; an impingement target; a support for said impingement target, said support having adjustment means permitting positioning of said impingement target at various locations in relation to a line between the centers of said central and discharge openings, afiording means for adjusting the fineness 'of dispersion of liquid in the aerosol produced by adjustment of the air-stream blocking location of said target; and a sleeve bordering said discharge opening and extending inward toward said central flange, whereby liquids in said nebulizer are prevented from escaping through said openings by said central flange and said sleeve.
3. The subject matter of claim 2 in which the interior of said sleeve has a frustoconical shape tapering as it extends inward and a plug removably disposed in said air discharge opening and between the walls of said sleeve, said plug having a shape matching the interior of said sleeve to seal said discharge opening, and a flexibie connector secured to said plug and to the walls of said nebulizer to prevent loss of said plug upon removal from said discharge opening.
A device for producing aerosol mist adjustable to atomize and nebulize liquids therein, comprising: walls defining a chamber having at one end an air ingress opening and having at its other end an air discharge opening; jet means including a resilient bulb connected to said air ingress opening and disposed to direct an air stream through said discharge opening; a liquid supply tube having its discharge end disposed between said ingress and discharge openings; an impingement target having an inwardly facing dome shaped impingement surface; a support for said impingement target, and said support having adjustment means permitting manual adjustment of said support to locate said impingement target at various locations in relation to a line between the centers of said ingress and discharge openings by movement substantially laterally of said line, aifording means for adjusting the fineness of dispersion of liquid in the aerosol by changing the air-stream blocking location of said impingement surface from a location of minimum interference when the liquid is atomized to a location of maximum interference when the liquid is finely nebulized. I
5. The subject matter of claim 4 in which said liquid supply tube is beveled on its top edge toward said jet means to adjacent the liquid passageway in the liquid supply tube in a plane forming an angle of approximately forty-five degrees to the path of travel of the air stream.
6. in a device for producing an aerosol mist, an air jet assembly, comprising: walls forming a chamber including a base portion having a central opening therethrough; a jet tube positioned in said central opening and connected to said base portion by web means and partially blocking said central opening, means forming a liquid reservoir in said device and a liquid supply tube extending from the liquid reservoir to adjacent the discharge end of said jet 7 7 tube, said jet tube extending outside of said chamber and a resilient bulb positioned thereon, said base unit having annular flange means bordering and forming a circular line of contact with the outer surface of said bulb when the bulb is uncompressed and said flange means being of a size and positioned to permit passage of air between said bulb and said flange means and through said central op ening into said chamber when said bulb is compressed.
7. A nebulizer, comprising: walls defining a chamber having at one end an air ingress opening and having at its other end an air discharge opening; jet means connected to said air ingress opening and disposed to direct an air stream through said discharge opening, said walls having means forming a dovetailed guideway and a liquid supply tube having its discharge end disposed between said ingress and discharge opening and having a slipper portion removably positioned in said guideway; an impingement target positioned between said ingress and discharge openings, said target being shaped in the form of two cones with their bases joined and with the'apex of one directed toward said air ingress opening and with the apex of the other directed toward said air discharge opening, and an arm connecting said target and said liquid supply tube for support of said target, said arm having an opening therethrough for anchoring of collected liquids on and arm.
8. The subject matter of claim 7 in which said liquid supply tube is beveled on its top edge toward said jet means so as to form an angle of approximately forty-five degrees to the path of'travel of the air stream.
9. The subject matter of claim 7 in which there is a removable throttling plug positioned in the liquid passageway of said liquid supply tube having a size to restrict the effective size of said passageway to control the amount of liquid passing through the same. a
10. The improvement in a nebulizer, comprising: a cup-like base with annular side walls and a bottom portion, a dome-like cover disposed on said base unit and interengaging, sealing threaded means between said annular side walls and the corresponding portion or" said cover, said cover having an air discharge opening therein, said base portion having jet air means including air pumping means attached thereto, means forming a dovetailed guideway on the inside surface of said annular side walls directed toward said bottom portion, a liquid supply tube having a liquid passageway and having a discharge end positioned adjacent said jet means and between the jet means and said air discharge opening, said liquid supply tube having at its other end a slipper portion extending obliquely therefrom and removably positioned in said dovetailed guideway securing the liquid supply tube in position, said slipper portion having a hollow, open bot- .tom for picking up liquid from said chamber, and a throttling plug similarly shaped to'said liquid supply tube and slipper portion and removably positioned therein, said plug having a finned portion positioned in the liquid passageway of the liquid supply tube spacing it from the adjacent walls.
11. The improvement in a nebulizer, comprising: a body having walls defining a chamber, one wall having jet air means including air pumping means attached thereto and anotherwall having an air discharge opening, a liquid supply tube having a liquid passageway and having a discharge end positioned adjacent said jet means and between the jet means and said air discharge opening, means on the inner surface of a wall of said body forming a dovetailed guideway and said liquid supply tube having at its other end a slipper portion removably positioned in said dovetailed guideway securing the liquid supply tube in position, said slipper portion having a hollow open wallabutting bottom for picking up liquid from said chamber, and a throttling plug similarly shaped to said liquid supply tube and slipper portion and removably positioned in said liquid passageway and said hollow bottom.
,12. The improvement in a device for producing an said target aerosol, comprising: a body having walls defining acham her having an air discharge opening in one end and having extends from an adjacent wall of said body to said dis-.
charge end and having a liquid ingress opening located near said adjacent wall permitting the tube to pick up liquid from the chamber, a throttling plug positioned in said liquid, supply passageway near said adjacent wall and having a size to restrictthe effective size of said liquid supply passageway to control the amount of liquid passing from the liquid egress opening toethe discharge end of said liquid supply tube, and manually operable means in the nebulizer providing access to the location of said throttling plug in said liquid supply passageway permitting removal of the plug.
13. The subject matter of claim 12 in which an impingement target is mounted in said chamber between said liquid supply tube and said air discharge opening in a manner permitting manual adjustment of position of the target relative a line between said air discharge opening and said jet nozzle so that said. target can be changed from a positionof minimum interference with the jet air stream when the liquid is atomized to a position of maximum interference when the liquid is finely nebulized.
14. The improvement in a nebulizer, comprising: a body having walls defining a chamber having an air discharge opening in one end, a jet nozzle positioned in the other end of said body and having air pumping means attached thereto, an impingement target mounted insaid body between said jet nozzle andsaid air discharge opening and in the path of the air stream from the nozzle, a liquid supply tube mounted in said body having a discharge end positioned adjacent said jet nozzle and between said jet nozzle and said impingement target-and in the path of the air stream from the nozzle with the longitudinal axis of the liquid supply tube extending laterally of the path of the air stream, said liquid supply tube having tubular walls forming a liquid supply passageway, the wall of the liquid supply tube at said discharge end on the side 7 toward said jet nozzle being beveled to adjacent the liquid passageway in the liquid supply tube in a plane forming an angle of approximately forty-five degrees to the path of travel of the air stream, the bevel forming aflat chordal surface in the air stream to subject liquid leaving said supply tube to a shearing action by the air stream.
15. The improvement in a nebulizer, comprising: a body having walls forming a chamber having an air discharge opening in one end and having a broad central air inlet opening at its other end; a jet tube positioned in said central opening and connected to the wall bordering the central opening by 'a web, the jet tube tapering as it extends toward the chamber and a resilient bulb positioned on the outer end of the jet tube; a tapered tube-like valve seat member, removably positioned in said jet tube, having an air passageway and an air jet valve having a valve stem of substantially smaller size than said air passageway radial fins acting as a stop limiting movement of the valve when it is moved to an open position by passage of air when the bulb is contacted; a liquid supply tubehaving a discharge end positioned adjacent the discharge end of said nozzle; and air-supply means by-passing said valve providing a source of air for said bulb during expansion of the 9 bulb, said air-supply means being adapted to close during contraction of the bulb.
16. The improvement in a nebulizer, comprising: a body having walls forming a chamber having an air discharge opening in one end and having a broad air inlet opening at its other end; a jet tube positioned in said inlet opening and connected to the wall bordering the inlet opening by a web, a resilient bulb positioned on the outer end of the jet tube; a liquid supply tube having a discharge end positioned adjacent the discharge end of said jet tube; a tube-like valve seat member, removably positioned in said jet tube, having an air jet passageway and an air jet valve having a valve stem of substantially smaller size than said air jet passageway slidably mounted therein and said valve having a valve head positioned at the chamber end of said jet tube and the valve head and jet tube having coacting surfaces operative to block said air jet passageway when the valve is moved to closed position by passage of air when the bulb is expanding, said body having an air supply passageway communicating with the outside of the chamber and extending laterally of the jet tube through said web to join the same at a point to the outside of said valve, said valve seat member having a slot aligned with said air supply passageway permitting air to flow from the air supply passageway to the jet air passageway, said air supply passageway having a one-way valve therein airoperated to permit air to pass therethrough only when said bulb is expanding.
17. The subject matter of claim 16 in which said air supply passageway has a removable annular valve seat plug positioned in the outer end thereof, said one-way valve being positioned on the inside of said plug and having a valve stem positioned in said plug, the one-way valve and plug having opposed beveled annular surfaces to seal the same when the one-way valve is moved by passage of air when the bulb is contracted, the air supply passageway having a lateral oblique surface adjacent said one-way valve and the plug having limited adjustment longitudinally of the passageway whereby the oblique surface forms an adjustable stop for the one-way valve.
18. The improvement in a device for producing an aerosol, comprising: a body having walls forming a chamber having an air discharge opening in one end and having a jet air tube in the other end including a nozzle; a liquid supply tube having a discharge end positioned adjacent the discharge end of said nozzle; a resilient bulb connected to said jet air tube and a first one-way check valve positioned in jet air tube between the bulb and the nozzle operable by the passage of air therethrough to slide axially of said tube to seal said tube against passage of air when the bulb is expanding; air ingress means forming an air passageway to the outside of said chamber and a second one-way check valve positioned in the air passageway of the air ingress means at a point spaced from said jet tube, said air ingress means being positioned between said first one-way valve and said bulb and communicating with said bulb; said second one-way valve being operable by the passage of air through the air passageway of the air ingress means to slide axially of said passageway to seal the same against passage of air therethrough when the bulb is contracting, said air jet tube including a valve seat member which is manually removable affording access to said first one-way valve for cleaning the first valve and air jet tube.
19. A device for producing aerosol mist adjustable to atomize and nebulize liquids therein, comprising: Walls defining a chamber having at one end an air ingress opening and having at its other end an air discharge opening; jet means including a resilient bulb connected to said air ingress opening and disposed to direct an air stream through said discharge opening; a liquid supply tube having its discharge end disposed between said ingress and discharge openings; an impingement target; a support for said impingement target, and said support having adjustment means permitting adjustment of said support to locate said impingement target at various locations in relation to a line between the centers of said ingress and discharge openings, affording means for adjusting the fineness of dispersion of liquid in the aerosol by changing the air-stream blocking location of said target from a location of minimum interference when the liquid is atomized to a location of maximum interference when the liquid is finely nebulized, said target being hollow and having generally the shape of a paraboloid, said target having an opening at its top and having a groove running down its end away from said air ingress opening and having a groove on either side, the ends of said grooves terminating in slots communicating with the inside of said target.
References Cited in the file of this patent UNITED STATES PATENTS 380,041 Kneuper Mar. 27, 1888 460,458 Bates Sept. 29, 1891 745,415 Bockel Dec. 1, 1903 788,757 Deeks May 2, 1905 2,111,841 Curry Mar. 22, 1938 2,406,997 Curry Sept. 3, 1946 2,488,988 Schmitt Nov. 22, 1949 2,586,845 McKinnon Feb. 26, 1952 2,598,239 Dulken et al May 27, 1952 FOREIGN PATENTS 1,011,397 France Apr. 2, 1952
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Cited By (15)

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US3018971A (en) * 1959-05-15 1962-01-30 Ralph G Cheney Atomizer
US3069097A (en) * 1961-07-10 1962-12-18 Ralph G Cheney Atomizer
US3097645A (en) * 1960-03-22 1963-07-16 Victor E Lester Nebulizer
US3172406A (en) * 1962-04-05 1965-03-09 Forrest M Bird Nebulizer
US3269665A (en) * 1964-11-02 1966-08-30 Ralph G Cheney Nebulizer
US4566452A (en) * 1982-07-12 1986-01-28 American Hospital Supply Corporation Nebulizer
US5287847A (en) * 1992-07-24 1994-02-22 Vortran Medical Technology, Inc. Universal nebulizer
EP0691862A1 (en) * 1994-02-02 1996-01-17 Allegiance Corporation Slit valve for nebulizer gas jet
US20070163575A1 (en) * 2005-12-30 2007-07-19 Rojas Antonio M Jr Nebulizer
US20080202506A1 (en) * 2007-02-27 2008-08-28 Mahoney Derek D Waterfall nebulizer
US20080283050A1 (en) * 2007-05-15 2008-11-20 Joseph Dee Faram Pre-filled, small-volume nebulizer
US20090272376A1 (en) * 2007-10-31 2009-11-05 Mahoney Derek J Nebulizer having a high efficiency impactor
US20130313341A1 (en) * 2012-05-22 2013-11-28 II Wesley P. Bauver Radial nozzle assembly for a pressure vessel
US10258758B1 (en) 2018-04-20 2019-04-16 Caddo Medical Technologies Llc Flow controlled valve for a small-volume nebulizer
US10342935B2 (en) 2017-11-21 2019-07-09 Caddo Medical Technologies Llc Internal nebulizer seal and method of use

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US3018971A (en) * 1959-05-15 1962-01-30 Ralph G Cheney Atomizer
US3097645A (en) * 1960-03-22 1963-07-16 Victor E Lester Nebulizer
US3069097A (en) * 1961-07-10 1962-12-18 Ralph G Cheney Atomizer
US3172406A (en) * 1962-04-05 1965-03-09 Forrest M Bird Nebulizer
US3269665A (en) * 1964-11-02 1966-08-30 Ralph G Cheney Nebulizer
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EP0691862A4 (en) * 1994-02-02 1996-10-30 Baxter Int Slit valve for nebulizer gas jet
US20070163575A1 (en) * 2005-12-30 2007-07-19 Rojas Antonio M Jr Nebulizer
US20080202506A1 (en) * 2007-02-27 2008-08-28 Mahoney Derek D Waterfall nebulizer
US20080283050A1 (en) * 2007-05-15 2008-11-20 Joseph Dee Faram Pre-filled, small-volume nebulizer
US9849254B2 (en) * 2007-05-15 2017-12-26 Caddo Medical Technologies Llc Pre-filled, small-volume nebulizer
US20180071464A1 (en) * 2007-05-15 2018-03-15 Caddo Medical Technologies Llc Pre-Filled, Small-Volume Nebulizer and Method of Manufacture
US10149950B2 (en) * 2007-05-15 2018-12-11 Caddo Medical Technologies Llc Pre-filled, small-volume nebulizer and method of manufacture
US20090272376A1 (en) * 2007-10-31 2009-11-05 Mahoney Derek J Nebulizer having a high efficiency impactor
US7992803B2 (en) * 2007-10-31 2011-08-09 Stevens Medical, Llc Nebulizer having a high efficiency impactor
US20130313341A1 (en) * 2012-05-22 2013-11-28 II Wesley P. Bauver Radial nozzle assembly for a pressure vessel
US9459006B2 (en) * 2012-05-22 2016-10-04 Alstom Technology Ltd Radial nozzle assembly for a pressure vessel
US10342935B2 (en) 2017-11-21 2019-07-09 Caddo Medical Technologies Llc Internal nebulizer seal and method of use
US10576221B2 (en) 2017-11-21 2020-03-03 Caddo Medical Technologies Llc Internal nebulizer seal and method of use
US10258758B1 (en) 2018-04-20 2019-04-16 Caddo Medical Technologies Llc Flow controlled valve for a small-volume nebulizer

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