Connect public, paid and private patent data with Google Patents Public Datasets

Closure

Download PDF

Info

Publication number
US2653611A
US2653611A US19735850A US2653611A US 2653611 A US2653611 A US 2653611A US 19735850 A US19735850 A US 19735850A US 2653611 A US2653611 A US 2653611A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
portion
stopper
closure
neck
annular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Arthur E Smith
Original Assignee
Arthur E Smith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/24Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • B65D51/2807Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
    • B65D51/2814Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it
    • B65D51/2842Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being provided with a preformed weakened line
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00Bottles and jars
    • Y10S215/08Mixing

Description

Sept. 29, 1953 A. E. SMITH 2,653,611

CLOSURE Filed Nov. 24, 1950 INVENTOR. AETHUPE SM/TH,

ATTOf/VE) Patented Sept. 29, 1953 UNITED STATES PATENT OFFICE CLOSURE Arthur E. Smith, Los Angeles, Calif.

Application November 24, 1950, Serial No. 197,358

4 Claims. 1

This invention relates to a closure for a container whereby a fresh drug solution may be prepared easily, quickly, accurately and may be maintained in a sterile condition.

Heretofore, it has been the practice among physicians, surgeons and nurses to prepare a fresh drug solution such as penicillin, or the like, by injecting a measured quantity of a solvent such as water or normal saline solution through a resilient bottle cap and into a bottle wherein a quantity of the dry drug had been placed. This process of mixing necessary fresh solutions permits considerable error in that not always does the preparer know or remember the exact amount of solvent to be used, the correct type of solvent, or does he necessarily maintain the solvent in a sterile condition. These measurements must be rigidly complied with to maintain the fresh drug solutions in their correct concentrations, a factor vital in the administration of such drugs.

The problem of sterility of the solution is one that must be taken into consideration. Often a quantity of solvent is withdrawn at many difierent times from the same container. In so doing it is practically impossible to maintain the solvent in a sterile condition. This condition is also aggravated by the fact that often there is poor sterilization of the syringes and needles in the mixing.

Therefore, it is the main object of this invention to provide a novel closure for a container whereby a fresh drug solution may be prepared rapidly and accurately and may be maintained in a sterile condition.

Another object of the present invention is to provide a novel container closure including a novel removable portion.

A further object of the invention is to provide a novel closure including a drug holding cavity.

A still further object of the present invention is to provide a novel closure including a drug holding cavity and a novel opening member for removing a wall of the cavity.

Other and further objects of the present invention will be apparent from the following description taken in connection with the accompanying drawings, wherein:

Fig. 1 is a sectional view of a container with the closure of this invention thereon;

Fig. 2 is a, view similar to Fig. 1, showing the container as it appears after the fresh solution has been prepared;

Fig. 3 is a transverse sectional view taken as indicated by line 3-3, Fig. 1;

Fig. 4 is an enlarged, fragmentary, sectional View of the actuating rod, together with the diaphragm and its associated frangible portion;

Fig. 5 is a fragmentary, sectional view of a modification of the invention, and

Fig. 6 is a view similar to Fig. 5, showing a further modification of the invention.

Referring to the drawing by reference characters, wherein like characters indicate like parts, the invention is shown as embodied in a container which is indicated generally at H]. As shown the container includes a bottle ll having a body portion l2 and a reduced neck portion [3. The upper end of the neck portion I3 is provided with an outwardly directed flange M which forms the upper end of an annular groove 15. The opening [6 in the bottle neck receives a stopper ll which has an outwardly directed annular flange I 8, adapted to rest on the flange M.

The stopper H has an opening l9 which is closed at the lower end by a diaphragm 20 which has a pair of opposed, upper and lower annular V-shaped grooves 2| and 22, which define a frangible or breakable portion 23. The portion 23, as shown, has a centrally positioned indentation 24 which is adapted to receive the lower end of an actuating member or rod 25, the upper end of which is retained in a collar which depends from a resilient, inverted, cup shaped closure member 28.

The closure member 28 has a downwardly extending side wall or skirt 29 which surrounds the flanges I4 and I8 of the bottle and the stopper and at its lower end has an inwardly directed annular bead 30 which lies in the groove l5 of the bottle neck I3 to retain the closure 28 in place. The central upper surface of the closure member 28 is provided with a slight indentation 3|, the use of which will be later described.

In use, the container is delivered to the user in the condition shown in Fig. l, with a quantity of a drug 32 in the space surrounding the rod 25 within the opening 19. The body I2 of the container is filled with the correct amount of the proper solvent or vehicle 33 for the drug being used.

To eifect mixing of the drug and the solvent, pressure is applied on the upper end of the closure 28, thus forcing the actuating member 25 downwardly and, due to its engagement with the frangible or breakable portion 23 of the diaphragm 20, causes the portion 23 to break away from the diaphragm 20 at the annular grooves 2| and 22. The rod 25, frangible portion 23 and the drug 32 will then fall into the solvent 33 to prepare a fresh solution. To obtain the required quantity of the prepared solution, a hypodermic needle connected to a syringe is inserted through the indentation 3! in the closure 28 and the required amount of solution is withdrawn into the syringe.

Thus it may be seen that the container of the invention is of such a nature that a fresh drug solution may be quickly, easily and accurately prepared and that the solution will remain sterile 1n the container.

Referring now to Fig. 5, wherein a modification of the invention is shown and wherein like parts are indicated by single primed reference numer als, the opening IS in the stopper ll receives H. An annular, V-shaped groove 43 is provided in the insert 40 adjacent the flange 4| to provide The flange 4| and a frangible area therefor.

groove 43 form a diaphragm. The insert 40 is;-

held in contact with the flange 42 by pressure on its upper end by the resilient closure 28. The insert 40 has an upwardly directed recess 44 wherein the drug 32' may be placed.

Pressure on the upper end of actuating member 4|! will cause the flange 4| to break from the insert 40 at the annular groove 43, whereupon the insert 40 together with the drug 32' will fall into the solvent 33 to be dissolved therein.

Referring now to the further modification of Fig. 6, wherein like parts are indicated by double primed reference numerals, the stopper I1" is provided with annular V-shaped opposed grooves 50 and 50 adjacent its upper flange l8. The flange l8 and V-sh-aped grooves 50 and 50 provide a diaphragm. A recess is provided in the lower portion of the stopper IT" to receive the drug 32".

Horizontal bores 52 connect the recess 5| with the outer periphery of the stopper. The recess 5| and the space 53 formed between the stopper I1" and the neck [3" of the bottle are sealed by a resilient closure 54 adapted to engage the opening IS" in the bottle neck and a roove 55 in the lower outer edge of the stopper H.

The stopper I7" is also provided, at its upper end, with a raised actuating member portion 56 which may be engaged by a closure 28". Pressure on the closure 28" and the portion 56 will cause the stopper IT" to break away from its flange l8 at the annular grooves 50 and 50', thus causing the stopper, lower closure 54 and the drug 32" to fall into the solvent 33", whereupon the solvent will pass through the bores 52 to be mixed with the drug 32".

Having thus described my invention, I claim:

1. In a container wherein a fresh drug solution may be prepared, a bottlehaving a body portion and a neck portion of reduced diameter, a stopper within said neck, portion and having an outwardly directed annular flange resting on the upper end of said neck portion, said stopper having an annular wall defining a recess adapted to hold a quantity of a drug, a removable diaphragm integral withsaid annular wall and closing said recess, an actuating rod in the stopper recess, said rod having a cross sectional area less than the area of the stopper recess, said actuating rod extending upwardly to a location above the upper end of said stopper flange, and an inverted cup shaped resilient closure member having a skirt portion engaging the stopper flange and engaging said bottle neck portion, said diaphragm and said closure having centering means thereon engaging the lower and, upper ends, respectively, of the rod.

2. In a container wherein a fresh drug solution may be prepared, a bottle having a body portion and a neck portion of reduced diameter, theupper end of said neck portion having an annular peripheral flange defining an annular groove about said neck portion adjacent to said body portion, a stopper within said neck portion and having an outwardly directed annular flange resting onthe upper. end of said neck portion, saidstopper having an. annularlwall defining a 4 recess adapted to hold a quantity of a drug, a diaphragm integral with said annular wall and extending across, and closing, said recess, there being a weakened portion on said diaphragm forming a removable section, an actuating rod in ,the stopper recess and having its lower end engaging said diaphragm, said rod having a cross sectional area less than the area of the stopper recess, means to center the lower end of said rod-on said diaphragm, said actuating rod extending upwardly to a location above the upper end of said stopper flange, and an inverted cup shaped resilient closure member having a skirt portion engaging the stopper flange, said skirt portion having an inwardly directed bead thereon engaging in said groove about said bottle neck portion, said closure having means thereon engaging the upper end of said rod to center the rod.

3. In a container wherein a fresh drug solution may be prepared, a bottle having a body portion and a neck portion of reduced diameter, the upper end of said neck portion having an annular peripheral flange defining an annular groove about said neck portion adjacent to said body portion, a stopper within said neck portion and having an outwardly directed annular flange resting on the upper end of said neck portion, said stopper having an annular wall defining a recess adapted to hold a quantity of a drug, a diaphragm integral with said annular wall and extending across and closing said recess, there being a pair of opposed annular V-shaped grooves on opposite sides of said diaphragm and forming a removable section, said removable section having a central indentation, an actuating rod in the stopper recess, said rod having a cross sectional area less than the area of the stopper recess and having its lower end arranged in said indentation, said actuating rod extending upwardly to a location above the upper end of said stopper flange, and an inverted cup shaped resilient closure member having a skirt portion extending over the stopper flange, said skirt portion having an inwardly directed bead thereon engaging in said groove about said bottle neck portion, said closure having a depending collar engaging the upper end of said rod.

4. In a container wherein a fresh solution may be prepared, a bottle having a body portion and a neck portion, a stopper within said neck portion and having an outwardly directed annular flange resting on the upper end of said neck portion, said stopper having an annular wall defining a recess adapted to hold a quantity of a drug, a removable diaphragm integral with said annular wall and closing said recess, an actuating rod in said stopper recess, said rod having a cross sectional area less than, the area of the stopper recess, said actuating rod extending upwardly to a location above the upper end of said stopper flange, and an inverted cup shaped resilient closure member having a skirt portion engaging the stopper flange and the bottle neck portion.

ARTHUR E. SMITH.

References Cited in the file of this patent UNITED STATES PATENTS Number Name Date 2,251,527 Smith Aug. 5, 1941, 2,275,567 Smith Mar. 10,1942 2,524,366 Smith Oct. 3, 1950 2,524,607 Smith Oct. 3, 1950

US2653611A 1950-11-24 1950-11-24 Closure Expired - Lifetime US2653611A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US2653611A US2653611A (en) 1950-11-24 1950-11-24 Closure

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2653611A US2653611A (en) 1950-11-24 1950-11-24 Closure

Publications (1)

Publication Number Publication Date
US2653611A true US2653611A (en) 1953-09-29

Family

ID=22729072

Family Applications (1)

Application Number Title Priority Date Filing Date
US2653611A Expired - Lifetime US2653611A (en) 1950-11-24 1950-11-24 Closure

Country Status (1)

Country Link
US (1) US2653611A (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2738890A (en) * 1953-04-03 1956-03-20 Thure W Dahl Devices for holding articles in a refrigerator container
US2764983A (en) * 1953-03-20 1956-10-02 Barasch Hans Pius Dual compartment mixing vial
US2807384A (en) * 1956-03-12 1957-09-24 Lipari Michael Compartmental dispensing receptacle
US2908418A (en) * 1956-05-28 1959-10-13 Frame Sa Closure device and process for the manufacture thereof
US2974785A (en) * 1956-07-06 1961-03-14 Griffon Henri Container for the separate storage and extemporaneous mixing of constituents in injectable solution
US3357545A (en) * 1965-11-01 1967-12-12 Koberly Inc Dental materials and apparatus for preparing the same
US3439823A (en) * 1967-06-06 1969-04-22 Oreal Container stopper comprising a hollow capsule
US3603484A (en) * 1969-02-28 1971-09-07 Mix O Matic Corp A two-compartment mixing and dispensing device
US3638918A (en) * 1970-03-09 1972-02-01 Dental Design Systems Mixing of substances
US3779372A (en) * 1971-04-01 1973-12-18 Lloret H De Container for the components of mixed drinks
US4103772A (en) * 1975-09-04 1978-08-01 Georg Wiegner Sealed container with frangible partition
US4121772A (en) * 1977-08-17 1978-10-24 Rubin Mandrell Portable spray can for dual liquids
US4174035A (en) * 1975-09-04 1979-11-13 Georg Wiegner Two-component container and package
US4465471A (en) * 1981-08-26 1984-08-14 Eli Lilly And Company Intravenous administration system for dry medicine
US4550825A (en) * 1983-07-27 1985-11-05 The West Company Multicompartment medicament container
US4657534A (en) * 1985-11-04 1987-04-14 Alcon Laboratories, Inc. Dual compartment, disposable, mixing and dispensing container
US5035320A (en) * 1990-05-07 1991-07-30 Clifford Plone Dispenser system with elongated selectively activatable dispensing pusher
US5147337A (en) * 1990-05-07 1992-09-15 Clifford Plone Medicament dispenser
US5804213A (en) * 1991-10-09 1998-09-08 Lectec Corporation Biologically active aqueous gel wound dressing
US6189688B1 (en) * 1997-02-07 2001-02-20 Biodome Multi-chamber dispensing container for storing at least two substances, the extemporaneous mixture of these substances, and distribution of the mixture
US6601577B2 (en) 2001-04-06 2003-08-05 Moshe Bouskila Container assembly for warming beverages and method of forming and using it
WO2004000678A1 (en) * 2002-06-25 2003-12-31 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Mixing vial
US20050070873A1 (en) * 1995-10-10 2005-03-31 The Compak Companies, Llc Constituent delivery system
US20070280042A1 (en) * 2004-09-29 2007-12-06 Yoshino Kogyosyo Co., Ltd. Container for mixing two liquids and the like
US20090188886A1 (en) * 2008-01-25 2009-07-30 Florian Troesch Liquid container system
US20100200437A1 (en) * 2009-02-09 2010-08-12 Darren Coon Dispensing Capsule
US20150239584A1 (en) * 2014-02-26 2015-08-27 Elc Management Llc Aerosol Package With Fermentation Propulsion

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2251527A (en) * 1933-11-03 1941-08-05 Arthur E Smith Syringe and ampoule
US2275567A (en) * 1933-11-03 1942-03-10 Arthur E Smith Container closure
US2524366A (en) * 1948-01-24 1950-10-03 Arthur E Smith Receptacle closure
US2524607A (en) * 1948-01-24 1950-10-03 Arthur E Smith Container closure device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2251527A (en) * 1933-11-03 1941-08-05 Arthur E Smith Syringe and ampoule
US2275567A (en) * 1933-11-03 1942-03-10 Arthur E Smith Container closure
US2524366A (en) * 1948-01-24 1950-10-03 Arthur E Smith Receptacle closure
US2524607A (en) * 1948-01-24 1950-10-03 Arthur E Smith Container closure device

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2764983A (en) * 1953-03-20 1956-10-02 Barasch Hans Pius Dual compartment mixing vial
US2738890A (en) * 1953-04-03 1956-03-20 Thure W Dahl Devices for holding articles in a refrigerator container
US2807384A (en) * 1956-03-12 1957-09-24 Lipari Michael Compartmental dispensing receptacle
US2908418A (en) * 1956-05-28 1959-10-13 Frame Sa Closure device and process for the manufacture thereof
US2974785A (en) * 1956-07-06 1961-03-14 Griffon Henri Container for the separate storage and extemporaneous mixing of constituents in injectable solution
US3357545A (en) * 1965-11-01 1967-12-12 Koberly Inc Dental materials and apparatus for preparing the same
US3439823A (en) * 1967-06-06 1969-04-22 Oreal Container stopper comprising a hollow capsule
US3603484A (en) * 1969-02-28 1971-09-07 Mix O Matic Corp A two-compartment mixing and dispensing device
US3638918A (en) * 1970-03-09 1972-02-01 Dental Design Systems Mixing of substances
US3779372A (en) * 1971-04-01 1973-12-18 Lloret H De Container for the components of mixed drinks
US4103772A (en) * 1975-09-04 1978-08-01 Georg Wiegner Sealed container with frangible partition
US4174035A (en) * 1975-09-04 1979-11-13 Georg Wiegner Two-component container and package
US4121772A (en) * 1977-08-17 1978-10-24 Rubin Mandrell Portable spray can for dual liquids
US4465471A (en) * 1981-08-26 1984-08-14 Eli Lilly And Company Intravenous administration system for dry medicine
US4550825A (en) * 1983-07-27 1985-11-05 The West Company Multicompartment medicament container
US4657534A (en) * 1985-11-04 1987-04-14 Alcon Laboratories, Inc. Dual compartment, disposable, mixing and dispensing container
US5147337A (en) * 1990-05-07 1992-09-15 Clifford Plone Medicament dispenser
US5035320A (en) * 1990-05-07 1991-07-30 Clifford Plone Dispenser system with elongated selectively activatable dispensing pusher
US5804213A (en) * 1991-10-09 1998-09-08 Lectec Corporation Biologically active aqueous gel wound dressing
US6406712B1 (en) 1991-10-09 2002-06-18 Lectec Corporation Aqueous gel and package for a wound dressing and method
US20050070873A1 (en) * 1995-10-10 2005-03-31 The Compak Companies, Llc Constituent delivery system
US6189688B1 (en) * 1997-02-07 2001-02-20 Biodome Multi-chamber dispensing container for storing at least two substances, the extemporaneous mixture of these substances, and distribution of the mixture
US6601577B2 (en) 2001-04-06 2003-08-05 Moshe Bouskila Container assembly for warming beverages and method of forming and using it
WO2004000678A1 (en) * 2002-06-25 2003-12-31 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Mixing vial
US20040228208A1 (en) * 2002-06-25 2004-11-18 The Government Of The United States Of America, Mixing vial
US8714808B2 (en) * 2004-09-29 2014-05-06 Yoshino Kogyosho Co., Ltd. Container for mixing two fluids
US20070280042A1 (en) * 2004-09-29 2007-12-06 Yoshino Kogyosyo Co., Ltd. Container for mixing two liquids and the like
US9718598B2 (en) 2004-09-29 2017-08-01 Yoshino Kogyosho Co., Ltd. Container for mixing two fluids
US20090188886A1 (en) * 2008-01-25 2009-07-30 Florian Troesch Liquid container system
US20100200437A1 (en) * 2009-02-09 2010-08-12 Darren Coon Dispensing Capsule
US7874420B2 (en) * 2009-02-09 2011-01-25 Darren Coon Affixable dispensing capsule
US20150239584A1 (en) * 2014-02-26 2015-08-27 Elc Management Llc Aerosol Package With Fermentation Propulsion

Similar Documents

Publication Publication Date Title
US3334628A (en) Vacuum indicating connection for surgical wound-closing apparatus
US3446179A (en) Dose time indicator closure means for receptacles
US3542023A (en) Minimix
US3527216A (en) Hypodermic syringe assembly
US3552387A (en) Combination syringe and vial
US3342180A (en) Disposable liquid-powder package and hypodermic syringe
US3336924A (en) Two compartment syringe package
US3434473A (en) Hypodermic needle unit with integral needle guard
US3354881A (en) Hypodermic needle protector
US3667657A (en) Disposable container
US3379326A (en) Container closure
US3143109A (en) Blood drawing device
US3080866A (en) Hypodermic needle
US3523532A (en) Hypodermic needle
US3578037A (en) Method for filling a syringe
US4171698A (en) Prefilled two-compartment syringe
US2832339A (en) Hypodermic injector
US6196998B1 (en) Syringe and tip cap assembly
US5334179A (en) Latching piercing pin for use with fluid vials of varying sizes
US5487737A (en) Storage and transfer bottle designed for storing a component of a medicamental substance
US4445895A (en) Prepackaged, disposable hypodermic syringes
US4979941A (en) Device suitable for mixing medication
US3460702A (en) Self-centering adapter cap for hypodermic needles
US4020839A (en) Medicament-dispensing package
US3931815A (en) Assembly having an adapter and a holder with a double ended needle