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US2549417A - Syringe ampoule - Google Patents

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Publication number
US2549417A
US2549417A US10943049A US2549417A US 2549417 A US2549417 A US 2549417A US 10943049 A US10943049 A US 10943049A US 2549417 A US2549417 A US 2549417A
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Prior art keywords
stopper
ampule
compartment
end
bore
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Frank E Brown
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FREDERICK M TURNBULL
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FREDERICK M TURNBULL
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing

Description

F. E. BROWN SYRINGE AMPOULE April 17, 1951 Filed Aug. 10, 1949 INVENTOR Patented Apr. 17, 1951 SYRINGE AMPOULE Frank E. Brown, Burbank, Calif., assignor to Frederick M. Turnbull, Los. Angeles, Calif.

I Application August 10, 1949, Serial No. 109,430

This invention relates to a structurally and functionally improved ampule for use as part of .a hypodermic syringe assembly.

It is an object of the invention to provide an improved ampule in which diluent and medicament may be maintained in sterile condition un-. til it is desired to perform an injection; the creation of the solutionat that time being achieved with minimum effort and expenditure of time.

A further object is that of furnishing ampule structures capable of economical manufacture by quantity production methods and which ampules may be readily charged with diluent and medicament either manually or by machines. I

With these and other objects in mind, reference is had to the attached sheet of drawings illustrating practical embodiments of the invention and in which:

Fig. 1 is a sectional side view'of one form of ampule and showing the same in -an initial and charged condition; I

Fig. 2 is a view similar toFig. 1 but illustrat- Claims. (Cl. 128272) ing the initial step in the manipulation of the ampule;

Fig. 3 shows the position which'the parts assume during the final stages of their manipulation;

Fig. 4 is a transverse sectional view taken along the line 44 and in the direction pfthe arrows asindicated inFig. 1i a I v Fig. 5 is a section of anfalternative design; 7

Fig. 6 is asectional side view of a pistonstopper which may be embraced in the assembly if and 7 is a similar view of' a closure stopper which may also be included in that assembly;

In these views the numeral I0 indicates a tubular ampule body preferably formed of glass although other materials might, in certain'instances, be employed. As shown in Figs. 1 to 3 one end of the ampule is closed by a piston type stopper H, the opposite end thereof being closed by a stopper 12. Between its ends the ampule body is formed with a pair of axially extending ribs l3. These are clearly shown in Fig. 4, it being understood that a greater or lessernumber of these ribs might be employed if desired. A

partition stopper [4 is mounted within the bore of the ampule and in advance of the ribs l3.

'In this manner compartments l5 and I6 are provided between stoppers II and I4 and I4 and I2. Compartment [5 receives a diluent and compartment I6 the medicament which will'ordinarily be in the form of a dry powder, crystals, tablets, etc., etc. Compartment [5 should be of smaller capacity than compartment l6. In fact,

,with an assembly of the latter type.

2 the central zones of ribs [3 may be to the left of the center of the device as shown in Figs'. 1 to 3. I

Stoppers ll, I2 and M are conveniently formed of rubber and ridged. Obviously where permissible they might be formed of other material. Stopper l4 may be solid. Stopper Il may be provided with an outwardly extending protuber ance IT. This may be screwthreaded for engagement with a correspondingly threaded end of an actuating stem (not shown). If desired, the threads might be eliminated to provide for a slip fit between these parts. Otherwise as shown in Fig. 6 the stopper might be formed with a threaded recess I8 to engage the threaded end of the actuating stem. Stopper [2 may, as-shown in Fig. 7, be formed with a head [9. In any event, it should be provided with a recess 20 or be' otherwise constructed so as to be capable of being readily penetrated by the inner end of a needle.

An ampule of this type may be used with syringes or barrels of various designs. ample, a holder mounting a double pointed needle may be employed as shown in United States Patent to Steuer 1,709,691 of April 16, 1929.. Under 'certain circumstances the ampule, may be employed in connection with a barrel having a thrust or post portion as shown in United States Patent to Hall 1,848,711 of March 8, 1932. However, it,

is contemplated that ordinarily an ampule embodying the present teachings will not be utilised For this reason the operation of the unit will be described in conjunction with the structure of a barrel similar to that of Steuer. In any event an actuator which may take one of numerous difierent forms is preferably employed.

Thus, a physician desiring to use the unit will,

Thereupon he apply an actuator to stopper II. will exert a thrust upon that stopper. Compartment [5 being filled with liquid diluent, it follows that such thrust will be imparted to stopper M which will therefore shift to the right as in Fig. 1 in substantial synchronism with the corresponding movements of stopper ll. vThe length of the by-pass ribs I3 being greater than the width of posite stopper faces. been facilitated by the inclined rib ends.

under continued thrust, will project to displace For ex- 3 the liquid through the ribs l3 into compartment H.

Such movement of the parts has been shown in Fig. 2. When stoppers H and it are moved into contact substantially all of the diluent will have been displaced to the medicament compartment. The ampule should now be agitated so that a proper solution is established within compartment [6. With continued thrust against stopper ll, stopper M will move into this compartment. Prior to such shifting of the parts, the inner pointed cannula end will have pierced stopper l2. Accordingly any air may be vented. Thereupon the needle may be caused to penetrate the epidermis. Continued thrust upon stopper II will cause this stopper as well as [4 to move as a unit in the manner shown in Fig. 3 to expel the solution through the cannula which has pierced stopper l2. The first named stoppers will continue to move until the entire solution has been expelled from compartment It.

Now referring to the alternative form of structure shown in Fig. 5 it is to be understood that an ampule of this type may be used with a holder or barrel having a thrust or post portion. Under proper manipulation ampules of the type heretofore described may be employed with such a barrel. However, the structure shown in Fig. 5 is preferred in this connection.

Thus, in this view the numeral 25 indicates the ampule body preferably formed of glass and having a closed rear end 26. The outer or open end of the ampule is closed by a stopper 2? which is preferably of the piston type and conveniently formed with an inwardly extending recess 28. A stopper 29 is disposed between the ends of the ampule within the bore of the same and provides a partition dividing that bore into compartments 30 and 3!. As illustrated compartment 35 has greater capacity than compartment 30 and stopper 29 has both of its faces recessed to furnish a central diaphragm portion 32.

Between stoppers 21 and 29 a suitable number of inwardly extending ribs '33 are provided. Inward of stopper 29 a similar-number. of ribs 34 are furnished. These ribs are integral with body 25' and in common with the ribs I3 described in connection with Fig. 4, preferably have inclined end portions. Ribs 33 and 34 are disposed in substantially immediate proximity to stopper 29 and have lengths in excess of the widths of stopper 2? and stopper 29. The forward ends of ribs 33 are spaced from stopper 2? a distance substantially equal to or slightly in excess of the width of stopper 21. Diluent is arranged withincompartment and a suitable quantity of dry medicament is disposed in compartment 3|.

In using a unit of this type a suitable actuator is employed to force stopper 2'! inwardly. Due to the fact that compartment 39 is filled with liquid diluent such inward movement of the stopper will cause stopper 29 to simultaneously move in a similar direction. As stopper 29 moves it will ride onto ribs 34 and thus by-pass passages will be furnished through which the liquid may flow into compartment 3|. During this operation of the parts, the ampule should be disposed in a substantially vertical direction. Such com- The ampule may now be agitated so that a suitable solution is provided. The space beyond the inner ends of ribs 34 and the end 26 of the ampule should preferably be in excess of the capacity of compartment 39. Therefore it is apparent that after the solution has been completed, stopper 29 may have shifted to a point where it begins to over-ride the rear ends of ribs 34 while stopper 2! is over-riding the forward ends of these ribs. Due to the elastic nature of these elements they will, of course, be somewhat compressed to present a lesser width than in their normal condition. As the stoppers occupy positions upon the ribs 34, passages by-passing both of these stoppers will be provided. Such passages will permit of a venting of the compressed air.

If now the upper end of the ampule is introduced into a barrel or holder havin a thrust portion it is apparent that upon the parts telescoping this thrust portion will bear against the outer face of stopper 21. The exposed innerend of the cannula or needle extending beyond the post or thrust portion should be relatively long. Therefore, this needle will penetrate both stopper 2'? and the diaphragm 32 of stopper 29. Accordingly, continued telescopic movement. of the ampule with respect to the barrel will first permit any entrapped air to be vented through the bore of the needle. Second, continued movement of the parts will cause stoppers 21 and 29 tc shift as a unit and function as the pistons. With such functioning they will displace the liquid solution within compartment3l through the needle bore so that a hypodermic injection may be achieved in the usual manner. As afore brought out any desired number of ribs may be employed.

Thus, among others, the several objects of the invention as specifically afore noted are accomplished. 'Obviously numerous changes in construction and rearrangement of the parts might be resortedto without departing from the spirit of the invention as defined by the claims.

I claim:

"1. An ampule including a tubular body, the bore of said body at a zone intermediate its ends being formed with an axially extending rib projecting inwardly within the borerinthe direction of the tube axis, said ribin conjunction with adjacent bore surfaces-providing a by-pass for liquid normally confined withinthe bore and to,

the rear of a resilientstopper as the latteris shifted axially of the bore in the zone of said rib.

2. An ampule including a tubular body, the bore of said body atazone intervening its ends being formed with a longitudinally extending rib pro-. jecting inwardly within the borein the direction of the tube ax is, said rib--in conjunctionwith adjacent bore surfacesproviding a by-pass, a stopper disposed adjacent said rib and providing a partition intermediate the ends of said body, a further stopper adjacentone end of said body and spaced from said first named stopper to furnish a compartment between the same, diluent within said compartment, said diluent flowing through said by-pass as said further stopper is shifted axially of the bore ,to cause similar shifting of said first named stopper in the zone of. said rib and said ampule beyond said rib providing a medicament compartment to receive the diluent flowing through said ,by-pass.

3. An .ampule includinga tubular imperforate body having one closed end portion, an'opposite open end, a construction in its bore intermediate such ends and a substantially uniform cylindrical bore portion inwardly of said open end, a stopper within such bore at a point adjacent'said constriction to provide between said stopper and the closed end portion a medicament compartment, a further stopper within the tube and adjacent the open end thereof to provide a second compartment between it and said first named compartmeint and diluent within said second compartment, whereby when pressure is exerted upon said further stopper such pressure will be transmitted to said first named stopper to shift the same relative to said constriction and permit diluent to enter said medicament compartment. Y

4. An ampule including a tubular imperforate body formed with an integral closed end portion, an opposite open end, a constriction in its bore intermediate such ends and a substantially uniform cylindrical bore portion inwardly of said open end, an imperforate stopper within such bore at a point adj acent'said constriction to provide between said stopper and closedend portion a medicament compartment, a piston type stopper having a recess .in its inner face, said piston-stopper being disposed within the tube and adjacent the openend thereof to provide a second compartment between it and said medicamentcompartment and diluent within said second compartment, whereby when pressure is exerted upon said piston-stopper to shift the same within said cylindrical bore towards said constriction such pressure will be transmitted to said first named stopper to shift the same relative to said constriction and permit diluent to enter said medicament compartment.

5. As an article of manufacture an ampule comprising an imperforate tubular body, an integral closing portion at one end of said body, the opposite end thereof being open and presenting adjacent such end a substantially uniform cylindrical bore portion, an inward extension forming REFERENCES CITED The following references are of record in the file of this patent:

UNITED STATES PATENTS Number Name Date 1,929,616 Vopata Oct. 10, 1933 1,943,120 Kabnick Jan. 9, 1934 2,184,152 Saffir Dec. 19, 1939 2,193,322 Lozier et a1 Mar. 12, 1940

US2549417A 1949-08-10 1949-08-10 Syringe ampoule Expired - Lifetime US2549417A (en)

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US2549417A US2549417A (en) 1949-08-10 1949-08-10 Syringe ampoule
US2717601A US2717601A (en) 1949-08-10 1951-03-16 Syringe ampule

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Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2607341A (en) * 1948-12-24 1952-08-19 Frederick M Turnbull Hypodermic syringe assembly
US2610628A (en) * 1950-05-09 1952-09-16 Compule Corp Plural-compartment admixing vial for segregated storage of ingredients of solutions and liquid mixtures
US2619087A (en) * 1951-05-09 1952-11-25 Foster Milburn Company Combined package and applicator
US2646798A (en) * 1950-09-21 1953-07-28 Frank E Brown Cartridge syringe
US2655919A (en) * 1951-04-17 1953-10-20 Charles B Goodstein Hypodermic syringe and cartridge therefor
US2660171A (en) * 1950-12-07 1953-11-24 Jr Fairleigh S Dickinson Vial
US2687728A (en) * 1951-04-25 1954-08-31 Copen Simon Irving Combination of several solutions for the hypodermic injection
US2695614A (en) * 1952-12-10 1954-11-30 Compule Corp Plural-compartment admixing vial
US2717601A (en) * 1949-08-10 1955-09-13 Frederick M Turnbull Syringe ampule
US2753868A (en) * 1952-07-21 1956-07-10 George H Seemar Pluri-compartment container with double-sealed partitioning chamber
US2893390A (en) * 1954-04-28 1959-07-07 Edgar H Wilburn Hypodermic syringes
US2896622A (en) * 1955-05-03 1959-07-28 Gruenenthal Chemie Injection ampoules for several media and intended to be used once
US2907329A (en) * 1955-01-26 1959-10-06 Milton J Cohen Hypodermic syringe
US2908274A (en) * 1953-06-29 1959-10-13 Abbott Lab Closure
DE1105113B (en) * 1958-10-27 1961-04-20 Faure Jean Marie Rohrfoermige spray vial
US3013557A (en) * 1959-04-13 1961-12-19 Hazleton Lab Inc Combination syringe, shipping container and centrifuge tube
US3059643A (en) * 1954-12-10 1962-10-23 Baxter Laboratories Inc Pumping apparatus
DE1291543B (en) * 1962-04-20 1969-03-27 Upjohn Co Mischbehaelter for the separate storage of two components of a solution or of a liquid mixture
US3494359A (en) * 1969-03-17 1970-02-10 Silver Jules Two compartment syringe with a single barrel
US3705582A (en) * 1969-09-23 1972-12-12 Marvin D Stumpf Breech loaded syringe and method of breech loading same
US3785481A (en) * 1970-08-12 1974-01-15 Goupil J Multi-chamber container
US3796303A (en) * 1967-05-05 1974-03-12 Goupil J Containers
US3976082A (en) * 1974-02-25 1976-08-24 German Schmitt Intracardial stimulation electrode
EP0144551A1 (en) * 1983-09-28 1985-06-19 Becton, Dickinson and Company Two-component medication syringe assembly
US4552266A (en) * 1978-08-14 1985-11-12 Johnson & Johnson Disposable dental capsule
US4599082A (en) * 1984-08-13 1986-07-08 Becton, Dickinson And Company Two-component syringe assembly
EP0206971A1 (en) * 1985-05-29 1986-12-30 VECTA GLASS COMPANY Ltd. Syringe for direct use
EP0219899A1 (en) * 1985-10-11 1987-04-29 Duphar International Research B.V Automatic injector
EP0298067A1 (en) * 1987-07-02 1989-01-04 Kabi Pharmacia Ab Method and device for injection
US4874381A (en) * 1988-02-16 1989-10-17 Arzheimittel Gmbh Apotheker Vetter & Co. Ravensburg Hypodermic syringe
US4941876A (en) * 1986-04-10 1990-07-17 Medicorp Holding S.A. Device for conditioning liquids or liquid and solid substances
US4994043A (en) * 1987-06-16 1991-02-19 Akzo N.V. Two compartment syringe
WO1991004003A1 (en) * 1989-09-14 1991-04-04 Medicorp Holding S.A. Elongate container having two compartments, one being an extension of the other
US5080649A (en) * 1990-02-07 1992-01-14 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Dual-compartment hypodermic syringe
US5865804A (en) * 1997-07-16 1999-02-02 Bachynsky; Nicholas Rotary cam syringe
US5865308A (en) * 1996-10-29 1999-02-02 Baxter International Inc. System, method and device for controllably releasing a product
US5971953A (en) * 1998-01-09 1999-10-26 Bachynsky; Nicholas Dual chamber syringe apparatus
US6149626A (en) * 1997-10-03 2000-11-21 Bachynsky; Nicholas Automatic injecting syringe apparatus
US6626870B1 (en) * 2000-03-27 2003-09-30 Artix Laboratories, Inc. Stoppering method to maintain sterility
US20030195489A1 (en) * 1999-09-24 2003-10-16 Atrix Laboratories, Inc. Coupling syringe system and methods for obtaining a mixed composition
US6659975B2 (en) * 2000-05-16 2003-12-09 Fuju Photo Film Co., Ltd. Plasma collecting device
US20040054332A1 (en) * 2002-09-18 2004-03-18 Ferguson Gary William Syringe device with resistive ridges and methods of use
US20040127846A1 (en) * 1999-09-24 2004-07-01 Dunn Richard L. Coupling syringe system and methods for obtaining a mixed composition
US20060178641A1 (en) * 2004-12-03 2006-08-10 Reynolds David L Extensible plunger rod for pharmaceutical delivery device
US20080091148A1 (en) * 2006-10-17 2008-04-17 Arte Corporation Combined container-syringe
US20120211378A1 (en) * 2010-11-17 2012-08-23 La Prairie, Inc. Two compartment container
US20130018352A1 (en) * 2011-07-12 2013-01-17 Kuo-Cheng Wu Multi-Medicament Container
US20140005636A1 (en) * 2012-06-29 2014-01-02 Yi-Lan Wang Multi-Compartment Pre-filled Mixing Syringes with Bypass
EP2742959A2 (en) 2012-12-13 2014-06-18 Schott AG Device for the storage of fluid, especially medicament

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1929616A (en) * 1932-04-29 1933-10-10 William O Vopata Double compartment ampule
US1943120A (en) * 1930-05-21 1934-01-09 Kabnick Stuart Hypodermic syringe
US2184152A (en) * 1939-10-27 1939-12-19 Jacob A Saffir Ampoule
US2193322A (en) * 1938-04-30 1940-03-12 Cook Lab Inc Controllable transfer element for multiple compartment ampules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1943120A (en) * 1930-05-21 1934-01-09 Kabnick Stuart Hypodermic syringe
US1929616A (en) * 1932-04-29 1933-10-10 William O Vopata Double compartment ampule
US2193322A (en) * 1938-04-30 1940-03-12 Cook Lab Inc Controllable transfer element for multiple compartment ampules
US2184152A (en) * 1939-10-27 1939-12-19 Jacob A Saffir Ampoule

Cited By (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2607341A (en) * 1948-12-24 1952-08-19 Frederick M Turnbull Hypodermic syringe assembly
US2717601A (en) * 1949-08-10 1955-09-13 Frederick M Turnbull Syringe ampule
US2610628A (en) * 1950-05-09 1952-09-16 Compule Corp Plural-compartment admixing vial for segregated storage of ingredients of solutions and liquid mixtures
US2646798A (en) * 1950-09-21 1953-07-28 Frank E Brown Cartridge syringe
US2660171A (en) * 1950-12-07 1953-11-24 Jr Fairleigh S Dickinson Vial
US2655919A (en) * 1951-04-17 1953-10-20 Charles B Goodstein Hypodermic syringe and cartridge therefor
US2687728A (en) * 1951-04-25 1954-08-31 Copen Simon Irving Combination of several solutions for the hypodermic injection
US2619087A (en) * 1951-05-09 1952-11-25 Foster Milburn Company Combined package and applicator
US2753868A (en) * 1952-07-21 1956-07-10 George H Seemar Pluri-compartment container with double-sealed partitioning chamber
US2695614A (en) * 1952-12-10 1954-11-30 Compule Corp Plural-compartment admixing vial
US2908274A (en) * 1953-06-29 1959-10-13 Abbott Lab Closure
US2893390A (en) * 1954-04-28 1959-07-07 Edgar H Wilburn Hypodermic syringes
US3059643A (en) * 1954-12-10 1962-10-23 Baxter Laboratories Inc Pumping apparatus
US2907329A (en) * 1955-01-26 1959-10-06 Milton J Cohen Hypodermic syringe
US2896622A (en) * 1955-05-03 1959-07-28 Gruenenthal Chemie Injection ampoules for several media and intended to be used once
DE1105113B (en) * 1958-10-27 1961-04-20 Faure Jean Marie Rohrfoermige spray vial
US3058467A (en) * 1958-10-27 1962-10-16 Faure Jean-Marie Hypodermic syringes
US3013557A (en) * 1959-04-13 1961-12-19 Hazleton Lab Inc Combination syringe, shipping container and centrifuge tube
DE1291543B (en) * 1962-04-20 1969-03-27 Upjohn Co Mischbehaelter for the separate storage of two components of a solution or of a liquid mixture
US3796303A (en) * 1967-05-05 1974-03-12 Goupil J Containers
US3494359A (en) * 1969-03-17 1970-02-10 Silver Jules Two compartment syringe with a single barrel
US3705582A (en) * 1969-09-23 1972-12-12 Marvin D Stumpf Breech loaded syringe and method of breech loading same
US3785481A (en) * 1970-08-12 1974-01-15 Goupil J Multi-chamber container
US3976082A (en) * 1974-02-25 1976-08-24 German Schmitt Intracardial stimulation electrode
US4552266A (en) * 1978-08-14 1985-11-12 Johnson & Johnson Disposable dental capsule
EP0144551A1 (en) * 1983-09-28 1985-06-19 Becton, Dickinson and Company Two-component medication syringe assembly
US4599082A (en) * 1984-08-13 1986-07-08 Becton, Dickinson And Company Two-component syringe assembly
EP0206971A1 (en) * 1985-05-29 1986-12-30 VECTA GLASS COMPANY Ltd. Syringe for direct use
US4713062A (en) * 1985-05-29 1987-12-15 Vecta Glass Company Ltd. Ready to use syringe
EP0219899A1 (en) * 1985-10-11 1987-04-29 Duphar International Research B.V Automatic injector
US4941876A (en) * 1986-04-10 1990-07-17 Medicorp Holding S.A. Device for conditioning liquids or liquid and solid substances
US4994043A (en) * 1987-06-16 1991-02-19 Akzo N.V. Two compartment syringe
US4968299A (en) * 1987-07-02 1990-11-06 Kabivitrum Ab Method and device for injection
EP0298067A1 (en) * 1987-07-02 1989-01-04 Kabi Pharmacia Ab Method and device for injection
US4874381A (en) * 1988-02-16 1989-10-17 Arzheimittel Gmbh Apotheker Vetter & Co. Ravensburg Hypodermic syringe
WO1991004003A1 (en) * 1989-09-14 1991-04-04 Medicorp Holding S.A. Elongate container having two compartments, one being an extension of the other
US5291991A (en) * 1989-09-14 1994-03-08 Becton Dickinson France S.A. Elongate container having two separate compartments, one being an extension of the other
US5080649A (en) * 1990-02-07 1992-01-14 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Dual-compartment hypodermic syringe
US5865308A (en) * 1996-10-29 1999-02-02 Baxter International Inc. System, method and device for controllably releasing a product
US5865804A (en) * 1997-07-16 1999-02-02 Bachynsky; Nicholas Rotary cam syringe
US6149626A (en) * 1997-10-03 2000-11-21 Bachynsky; Nicholas Automatic injecting syringe apparatus
US5971953A (en) * 1998-01-09 1999-10-26 Bachynsky; Nicholas Dual chamber syringe apparatus
US20030195489A1 (en) * 1999-09-24 2003-10-16 Atrix Laboratories, Inc. Coupling syringe system and methods for obtaining a mixed composition
US20040127846A1 (en) * 1999-09-24 2004-07-01 Dunn Richard L. Coupling syringe system and methods for obtaining a mixed composition
US8226598B2 (en) 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
US6626870B1 (en) * 2000-03-27 2003-09-30 Artix Laboratories, Inc. Stoppering method to maintain sterility
US6659975B2 (en) * 2000-05-16 2003-12-09 Fuju Photo Film Co., Ltd. Plasma collecting device
US20040054332A1 (en) * 2002-09-18 2004-03-18 Ferguson Gary William Syringe device with resistive ridges and methods of use
US6972006B2 (en) 2002-09-18 2005-12-06 G6 Science Corp. Syringe device with resistive ridges and methods of use
US20060178638A1 (en) * 2004-12-03 2006-08-10 Reynolds David L Device and method for pharmaceutical mixing and delivery
US20060178644A1 (en) * 2004-12-03 2006-08-10 Reynolds David L Pharmaceutical cartridge assembly and method of filling same
US20060178641A1 (en) * 2004-12-03 2006-08-10 Reynolds David L Extensible plunger rod for pharmaceutical delivery device
US20080091148A1 (en) * 2006-10-17 2008-04-17 Arte Corporation Combined container-syringe
US20120211378A1 (en) * 2010-11-17 2012-08-23 La Prairie, Inc. Two compartment container
US9707157B2 (en) * 2011-07-12 2017-07-18 Kuo-Cheng Wu Multi-medicament container
US20130018352A1 (en) * 2011-07-12 2013-01-17 Kuo-Cheng Wu Multi-Medicament Container
US20140005636A1 (en) * 2012-06-29 2014-01-02 Yi-Lan Wang Multi-Compartment Pre-filled Mixing Syringes with Bypass
US9731076B2 (en) * 2012-06-29 2017-08-15 Ethicon, Inc. Multi-compartment pre-filled mixing syringes with bypass
EP2742959A2 (en) 2012-12-13 2014-06-18 Schott AG Device for the storage of fluid, especially medicament
DE102012024371A1 (en) * 2012-12-13 2014-06-18 Schott Ag Device for storing storage of liquid media, in particular drugs and methods for dispensing liquid media
US9700682B2 (en) 2012-12-13 2017-07-11 Schott Ag Device for retaining and storing liquid media and method of expelling the liquid media

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