US2513014A - Apparatus for implanting medicinal pellets subcutaneously - Google Patents

Apparatus for implanting medicinal pellets subcutaneously Download PDF

Info

Publication number
US2513014A
US2513014A US71062146A US2513014A US 2513014 A US2513014 A US 2513014A US 71062146 A US71062146 A US 71062146A US 2513014 A US2513014 A US 2513014A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
needle
end
cartridge
pellets
stylet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Mack R Fields
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069Devices for implanting pellets, e.g. markers or solid medicaments

Description

June 27, 1950 2,513,014

M. R. FIELDS APPARATUS FOR IMPLANTING MEDICINAL PELLETS SUBCUTANEOUSLY Filed Nov. 18, 1946 [72092257 mack E fE'Z'ai'' A, 9 W

Patented June 27, 1950 APPARATUS FOR IMPLANTING MEDICINAL PELLETS SUBGUTANEOUSLY v Mack R. Fields, Chicago, Ill., assi'gi'ior to Abbott Laboratories, of Illinois North Chicago, 111., "a corporation Application November 18, 1946, Serial No. 710,621

' g invention relates to apparatus for implanting medicinal pellets subcutaneously.

'In the treatment oi: pertain ailments 'by the use i of therapeutic'ag'ents such as hormone principles,

penicillin. streptomycin; and possibly other medicinal elements. it is highly desirable to maintain within the body a so-called' tissuefiuids and blood level of the'medicationin fixed proportions for aprolonged period. Most medicinal agents of the character indicated tend to di ate rapidly through absorptioninto the body'iiuids, thereby necessitating a frequent administration'of the desired medicinal agents in order to maintain the desired blood level. It has been found that it is possible to prepare medications of the type-above is present in the blood stream and tissue fluids at a required level 01 a period of several days;

The objects of the present invention are to provide a simple and easily manipulated means for implanting medicinal pellets subcutaneously; to provide such means whereby handling of the individual pellets is "avoided with attendant benefits in respect of the preservation of the sterile or aseptic condition of the pellets; and to provide an improved pellet package whereby distribution of pellets of therapeutic agents'of the character indicated in-sterile or aseptic condition-is greatl facilitated. 1

Other objects and advantages of the invention will be understood by reference to the following specification and accompanying drawing in which there is illustrated a selected form of'the apparatus and a selected form of pellet package embodying the invention.

In the drawing:

Figs. 1 and 2 are side and end views respectively of a needle structure,

Fig. 3 is a side view partially in elevation and partially in section of a pellet package or cartrid'ge, and

Fig. 4 is a sectional illustration of the manner in which the pellet cartridge of Fig. 3 and the needle structure of Fig. 1 are employed for the In some cases it v 2 Claims. (Cl. 1-28.2 17) purpose of subcutaneously implanting medicinal pellets supplied to the physician in the packaged form illustrated in Fig. 3.

For, penetrating the tissues, a needle I isemployed, the said needle being a tubular member having a bevelled or sharpened end 2 At the other end, the needle I is provided with anenlar'gement or head 3 which is suitably secured rigidl ron the blunt end portion of the needle preferably in co-axial relation thereto. The head is fcounterbored from its free outer or rear end as indicated at 4 for a purpose whichwill presently appear. v H

A stylet or removable core 5 is associated with the needle I, said stylet having a bevelled end portion 6 which isnormal-ly in co-planar relation to the bevelled end 2 of the needle I. Said stylet 5 is of a diameter which fits slidably within the lumen I of the needle so that the stylet tmay be readily inserted and withdrawn from the needle. The other end of the stylet is provided with a laterally bent end portion 8, andthe head 3 0f the needle isprovided with a radially extending groove 9 for receiving said stylet end portion 8 to thereby rotatably position the stylet in the needle with the bevelled ends of the stylet and needle in th desired co-planar relationship.

The pellet cartridge shown in Fig. 3 comprises a tubular and preferrably'a transparent body If] having abore l l of substantially the same diameter as the diameter of the lumen I of the needle. "Some variation is permitted in this respect, but it is preferable that thesediameters beapproximately the same so that pellets such .as represented at l2 and I3 fitting slidably in the bore of the cartridge body will also be slidable through the lumen of the needle. For closing the ends of the tubular cartridge body It, caps or end closures l4 -M of rubber or other suitable material, preferably resilient material, are applied to the cartridge ends as shown. These caps l4l4 are preferably of such size that they may be stretched when applied to the cartridge ends to such an extentthat they will frictional-1y grip the cartridge body end portions to thereby retain themselves in place while at the same time being readily removable when desired.

At one end, the cartridge body is provided with a flaring mouth entrance It to the bore l I therein to facilitate insertion of the pellets such as l2 and stylet whichprojects beyond the flattened edge 18 ofthe head, servetoindicatejthe position of the bevel of ,the. .nee'dle. .Whentheneedle has been inserted to the proper position, the stylet the needle.

I 3 into the body. As represented in Fig. 3, the

pellets I3 are about. twice the length of the pellet I2. Other length relationship may, of course, be employed depending upon the dosage required.

With the described apparatus, medicinal pellets may be implanted under the skin as follows:

The assembled needle and stylet I and 5 in the relationship shown in Fig. 1 is first inserted through the tissues to.locate the bevelled discharge end of the needle at the required place under the tissues. During insertion of the needle,

the physician :(.or;.nurse) holds the head of the needlebetween the index and middle fingers while placing the thumb against the rear end of the head in overlying relation to the laterally extending end portion 8 of the stylet. By so holding the needle, the stylet-is held against rearward displacement during the insertion of the needle. The head is of generally cylindrical.form having a suitably grooved jor recessed central annular portion I6 to facilitate holding of the needle between the index and middle fingers, and a rear flange portion I1 of the head has flattened edge portions I8 and I9 which are preferably arranged in planes which are parallel to the gen- .eral: plane of the bevelled. ends of the needle and stylet. The groove 9 in (the rear end of the needle head and the portion of .the bent end. 8-of the withdrawn leaving the hollowneedle in place.

' hump in the patients skin just when withdrawal of the needle should begin so as to leave the pellets in the desired location. Also, the length of plunger remaining between the outer or free end of the cartridge body and the adjacent portion of the eye ZI constitutes another indicator as to when withdrawal of the needle should begin. It will be observed that said distance between the cartridge and plunger eye is always equal to the combined length of the pellets remaining in the discharge end portion of the needle? I I 'I-To facil itate the passage of pellets from the cartridge I0 into the lumen of the needle I, the

ntrance end of the lumen is flared as indicated at 23. I n the construction shown, the entrance end of the needle I communicates directly with -the*counterbore 4. This, of course, may be modified to :provide theflared mouth 23 in a portion of the. head--"3,'the needle receiving recess then terminatin sshortof the bottom of the counteriPresent manufacturing equipment and processesdndicate that the smallest diameter to which pellets of therapeutic agents of the kind referred to may be made is about 0.85 inch (slightly more than of an inch).,--the length'being Variable I but preferablynot muchQmore than a of arrinch.

.A cartridge Ill containing the desired pellet (or pellets) is then prepared for assembly with .-.the. ,needle by removing one of the end caps I4, and then inserting the open end of the cartridge body into the recess or socket 4 provided for that 'purpose in the head of .the needle. The cartridge- .body [0 is preferably of-cylindrical form corre-,

sponding to thecylindricalcounterbore 4, and of ,ansexternal diameter which will. fit snugly in said counterboreso that when oneend portion of the cartridge is inserted into the counterbore, the cartridge will be positioned with its bore I l in the desired co-axial relationship to the'lumen I of Thereupon the otherend closure. is removed from the cartridgeand a plunger or pistonlfl (Fig. 4) is inserted intoand through the a cartridge body and into and through the needle I.

,The piston 2!] may consist of a length of wire pl adiameter which willfit freely through the hereof the cartridgeand the lumen of the needle and it isprovided with an eye 2| for facilitating ,handling-thereof. Thepiston and eye are made so that when the end 22' of the piston reachesia predetermined relationship to the bevelled end of the needle as represented in dotted lines at2 2a, move-' ment of the piston will be stopped by engagement of a portion of the eye :ZI with-the then outer end of the cartridge I0. As the piston is advanced, the pellets I2 and I 3 will, of course, be fed forwardly through and out of the cartridge and through the lumenof the needle. When the leading pellet reaches the bevelledend-of the needle and the tissue barrier closing the same;

movement of the piston is stopped and the needle is withdrawn while the piston is, in effect, held stationary so as to causethepellets to be discharged from the needle, thepellets being thereby deposited in the space vacated by the needle before the muscular tissue (or fat) can return toits normal position and close saidspace. ,-Physicians and others experienced in .matters ;of this 1 kind.v a determ n byithe 'formationof-i a-yisibl Theneedle I to handle,pelletsofthatsizewilL-on the basis of-pre'sentpractical manufacturing .procedures, have anexternial diameter of -about 1 12 inch. For insertionofa needle of that size itis, of course, preferable, if..not necessary, that the 7 affected body .part be-initially treated withasuitable anesthetic .to ,prevent excessive -pain. It

.should, however, beunderstoodthat as manufacturingequipment and processes improve; the indicated. dimensions maybe reduced .to .the end that ;a. smaller needle :may be, v employed EWlthout .requiring the use of a ;local anesthetic.

Various changesin the .describedstruc'turemay bemade without-departing from the spirit -of the invention as'defined in the claims in this' application.

I claim 2-,

1. Apparatus forimplanting a pellet'subcutane- 'ously, comprising an elongated hollow ne'edle and -a;stylet extending through said needle, said needle and stylet having complementary-sharpenedends for tlssue--penetrati0n purposes, said needle having an enlarged'head onits rear end needle and stylet ,havingcoplanar bevel-sharpened ends for tissue penetration purposes, said needle .having an venlarged head on its rear .end

, substantiallycoaxial withsaid needle .and provided with a socket in coaxial communication-with the .lumen 0f said needle,'said socket being of substantially larger diameter thanthe 2111111811 of 75,.$a ;,nees 1, an ada t d e iv ja n 0 tion of a pellet cartridge from which a pellet may be advanced into and through said needle,

the rearmost portion of said head having a flattened side portion and, in its rear face,'a slot extending radially of said head from said flattened 5 MACK R. FIEIDS.

REFERENCES CITED The following references are of record in the file of this patent:

UNITED STATES PATENTS Number Name I Date 1,655,158 Muir Jan; 3, 1928 1,960,858 Strauch May 29, 1934 2,009,393 ,Failla July 30, 1935 2,176,041 Pittenger Oct. 10, 1939 2,426,535 Turkel Aug. 26, 1947 OTHER REFERENCES Medical Journal and Record, vol. CXXII, July-Dec. 1925; pages 227-229, article by P. E. Durham. A copy, is in the Army Medical Library at Washington, D. C. V

US2513014A 1946-11-18 1946-11-18 Apparatus for implanting medicinal pellets subcutaneously Expired - Lifetime US2513014A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US2513014A US2513014A (en) 1946-11-18 1946-11-18 Apparatus for implanting medicinal pellets subcutaneously

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2513014A US2513014A (en) 1946-11-18 1946-11-18 Apparatus for implanting medicinal pellets subcutaneously

Publications (1)

Publication Number Publication Date
US2513014A true US2513014A (en) 1950-06-27

Family

ID=24854820

Family Applications (1)

Application Number Title Priority Date Filing Date
US2513014A Expired - Lifetime US2513014A (en) 1946-11-18 1946-11-18 Apparatus for implanting medicinal pellets subcutaneously

Country Status (1)

Country Link
US (1) US2513014A (en)

Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2666435A (en) * 1950-12-19 1954-01-19 Schering Ag Surgical injection device
US2751907A (en) * 1953-09-18 1956-06-26 Bishop & Co Platinum Works J Pellet injector
US2761446A (en) * 1955-03-30 1956-09-04 Chemical Specialties Co Inc Implanter and cartridge
DE1223495B (en) * 1956-08-24 1966-08-25 Foundation Lab Inc A device for subcutaneous implantation of Hormonpraeparaten u. the like. in animal bodies
US3757781A (en) * 1971-09-17 1973-09-11 R Smart Tool for administering pills to animals
US3921632A (en) * 1974-08-16 1975-11-25 Frank M Bardani Implant device
US4205678A (en) * 1976-05-11 1980-06-03 Adair Edwin Lloyd Method and apparatus for attaching an ostomy bag
US4451253A (en) * 1980-12-18 1984-05-29 Harman Sherman M Means and method for administering medicinals
US4451254A (en) * 1982-03-15 1984-05-29 Eli Lilly And Company Implant system
WO1988006905A1 (en) * 1987-03-18 1988-09-22 Endocon, Inc. Injector for implanting multiple pellet medicaments
US4820267A (en) * 1985-02-19 1989-04-11 Endocon, Inc. Cartridge injector for pellet medicaments
US4832680A (en) * 1986-07-03 1989-05-23 C.R. Bard, Inc. Apparatus for hypodermically implanting a genitourinary prosthesis
US4900304A (en) * 1986-07-30 1990-02-13 Sumitomo Pharmaceuticals Company, Limited Solid preparation administering instrument
US4915686A (en) * 1987-08-18 1990-04-10 Akzo N.V. Implant injection device
US4994028A (en) * 1987-03-18 1991-02-19 Endocon, Inc. Injector for inplanting multiple pellet medicaments
US5266325A (en) * 1990-09-28 1993-11-30 Hydro Med Science Division Of National Patent Development Corp. Preparation of homogeneous hydrogel copolymers
US5292515A (en) * 1990-09-28 1994-03-08 Hydro Med Sciences, A Division Of National Patent Development Corporation Manufacture of water-swellable hydrophilic articles and drug delivery devices
US5292307A (en) * 1992-09-16 1994-03-08 Dolzine Theodore W Dispensing package for unit dosage
US5437603A (en) * 1993-09-14 1995-08-01 C.R. Bard, Inc. Apparatus and method for implanting prostheses within periurethral tissues
US5582591A (en) * 1994-09-02 1996-12-10 Delab Delivery of solid drug compositions
US5660846A (en) * 1994-09-02 1997-08-26 Societe De Conseils De Recherches Et D'applications Scientifiques Methods and apparatus for the delivery of solid drug compositions
US5827293A (en) * 1996-05-13 1998-10-27 Elliott; James B. Subcutaneous insertion device
US5830228A (en) * 1996-05-29 1998-11-03 Urosurge, Inc. Methods and systems for deployment of a detachable balloon at a target site in vivo
US6488649B1 (en) 1998-11-24 2002-12-03 Edward M. Lichten Implant device
US20030004534A1 (en) * 2001-06-01 2003-01-02 George Stephanie A. Balloon transporter
US6530896B1 (en) 1996-05-13 2003-03-11 James B. Elliott Apparatus and method for introducing an implant
US6953007B1 (en) * 2002-04-03 2005-10-11 Cummings James C Pet training device
US6964669B1 (en) 2000-04-12 2005-11-15 Ams Research Corporation Linear delivery system for deployment of a detachable balloon at a target site in vivo
US20060253065A1 (en) * 2000-08-24 2006-11-09 Bardy Gust H Instrument for implanting sensors and solid materials in a subcutaneous location and method thereof
US7160325B2 (en) 2001-05-15 2007-01-09 Ams Research Corporation Implantable medical balloon and valve
US20070249992A1 (en) * 2000-08-24 2007-10-25 Bardy Gust H Subcutaneous implantation instrument with dissecting tool and method of construction
US20080097335A1 (en) * 2006-08-04 2008-04-24 Allergan, Inc. Ocular implant delivery assemblies
US20080311170A1 (en) * 2007-04-27 2008-12-18 Indevus Pharmaceuticals, Inc. Implant device release agents and methods of using same
US20090264813A1 (en) * 2006-06-19 2009-10-22 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US20100021522A1 (en) * 2008-06-25 2010-01-28 Endo Pharmaceuticals Solutions Inc. Sustained delivery of exenatide and other peptides
US20100185205A1 (en) * 2009-01-16 2010-07-22 Allergan, Inc. Interocular injector
US20100247594A1 (en) * 2005-03-11 2010-09-30 Endo Pharmaceuticals Solutions Inc. Delivery of dry formulations of octreotide
US20100317579A1 (en) * 2005-03-11 2010-12-16 Endo Pharmaceuticals Solutions Inc. Controlled release formulations of octreotide
US20100324578A1 (en) * 2000-08-24 2010-12-23 Bardy Gust H Instrument With A Two-Part Plunger For Subcutaneous Implantation
US20100324579A1 (en) * 2000-08-24 2010-12-23 Bardy Gust H Instrument With A Covered Bore For Subcutaneous Implantation
US20100331868A1 (en) * 2000-08-24 2010-12-30 Bardy Gust H Method For Constructing An Instrument With A Two-Part Plunger For Subcutaneous Implantation
US20100331874A1 (en) * 2000-08-24 2010-12-30 Bardy Gust H Method for constructing an instrument with a covered bore for subcutaneous implantation
US7960335B2 (en) 2008-06-25 2011-06-14 Endo Pharmaceuticals Solutions Inc. Octreotide implant having a release agent and uses thereof
US8062652B2 (en) 2004-06-17 2011-11-22 Endo Pharmaceuticals Solutions Inc. Compositions and methods for treating precocious puberty
US20130261596A1 (en) * 2012-03-28 2013-10-03 Warsaw Orthopedic, Inc. Drug delivery system
US20150080845A1 (en) * 2013-03-14 2015-03-19 Allergan, Inc. Polymer system for securing implants in syringe needles

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1655158A (en) * 1926-09-08 1928-01-03 Radium Emanation Corp Instrument for implanting radon seeds
US1960858A (en) * 1931-07-15 1934-05-29 Strauch Clauss Burkart Combination of two incompatibles
US2009393A (en) * 1930-06-12 1935-07-30 Failla Gioacchino Means for effecting therapeutic implantations
US2176041A (en) * 1936-06-25 1939-10-10 Sharp & Dohme Inc 1929 Container for lyophilic biologically active substances
US2426535A (en) * 1944-10-21 1947-08-26 Turkel Henry Infusion and biopsy needle

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1655158A (en) * 1926-09-08 1928-01-03 Radium Emanation Corp Instrument for implanting radon seeds
US2009393A (en) * 1930-06-12 1935-07-30 Failla Gioacchino Means for effecting therapeutic implantations
US1960858A (en) * 1931-07-15 1934-05-29 Strauch Clauss Burkart Combination of two incompatibles
US2176041A (en) * 1936-06-25 1939-10-10 Sharp & Dohme Inc 1929 Container for lyophilic biologically active substances
US2426535A (en) * 1944-10-21 1947-08-26 Turkel Henry Infusion and biopsy needle

Cited By (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2666435A (en) * 1950-12-19 1954-01-19 Schering Ag Surgical injection device
US2751907A (en) * 1953-09-18 1956-06-26 Bishop & Co Platinum Works J Pellet injector
US2761446A (en) * 1955-03-30 1956-09-04 Chemical Specialties Co Inc Implanter and cartridge
DE1223495B (en) * 1956-08-24 1966-08-25 Foundation Lab Inc A device for subcutaneous implantation of Hormonpraeparaten u. the like. in animal bodies
US3757781A (en) * 1971-09-17 1973-09-11 R Smart Tool for administering pills to animals
US3921632A (en) * 1974-08-16 1975-11-25 Frank M Bardani Implant device
US4205678A (en) * 1976-05-11 1980-06-03 Adair Edwin Lloyd Method and apparatus for attaching an ostomy bag
US4451253A (en) * 1980-12-18 1984-05-29 Harman Sherman M Means and method for administering medicinals
US4451254A (en) * 1982-03-15 1984-05-29 Eli Lilly And Company Implant system
US4820267A (en) * 1985-02-19 1989-04-11 Endocon, Inc. Cartridge injector for pellet medicaments
US4832680A (en) * 1986-07-03 1989-05-23 C.R. Bard, Inc. Apparatus for hypodermically implanting a genitourinary prosthesis
US4900304A (en) * 1986-07-30 1990-02-13 Sumitomo Pharmaceuticals Company, Limited Solid preparation administering instrument
US4994028A (en) * 1987-03-18 1991-02-19 Endocon, Inc. Injector for inplanting multiple pellet medicaments
US4846793A (en) * 1987-03-18 1989-07-11 Endocon, Inc. Injector for implanting multiple pellet medicaments
WO1988006905A1 (en) * 1987-03-18 1988-09-22 Endocon, Inc. Injector for implanting multiple pellet medicaments
US4915686A (en) * 1987-08-18 1990-04-10 Akzo N.V. Implant injection device
US5292515A (en) * 1990-09-28 1994-03-08 Hydro Med Sciences, A Division Of National Patent Development Corporation Manufacture of water-swellable hydrophilic articles and drug delivery devices
US5266325A (en) * 1990-09-28 1993-11-30 Hydro Med Science Division Of National Patent Development Corp. Preparation of homogeneous hydrogel copolymers
US5292307A (en) * 1992-09-16 1994-03-08 Dolzine Theodore W Dispensing package for unit dosage
US5437603A (en) * 1993-09-14 1995-08-01 C.R. Bard, Inc. Apparatus and method for implanting prostheses within periurethral tissues
US6142972A (en) * 1994-09-02 2000-11-07 Delab Method and apparatus for the delivery of elongate solid drug compositions
US5582591A (en) * 1994-09-02 1996-12-10 Delab Delivery of solid drug compositions
US5616123A (en) * 1994-09-02 1997-04-01 Delab Delivery of solid drug compositions
US5660846A (en) * 1994-09-02 1997-08-26 Societe De Conseils De Recherches Et D'applications Scientifiques Methods and apparatus for the delivery of solid drug compositions
US6306420B1 (en) 1994-09-02 2001-10-23 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Methods and apparatus for the delivery of solid drug compositions
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US5827293A (en) * 1996-05-13 1998-10-27 Elliott; James B. Subcutaneous insertion device
US5908404A (en) * 1996-05-13 1999-06-01 Elliott; James B. Methods for inserting an implant
US6530896B1 (en) 1996-05-13 2003-03-11 James B. Elliott Apparatus and method for introducing an implant
US5830228A (en) * 1996-05-29 1998-11-03 Urosurge, Inc. Methods and systems for deployment of a detachable balloon at a target site in vivo
US6488649B1 (en) 1998-11-24 2002-12-03 Edward M. Lichten Implant device
US6964669B1 (en) 2000-04-12 2005-11-15 Ams Research Corporation Linear delivery system for deployment of a detachable balloon at a target site in vivo
US20100249696A1 (en) * 2000-08-24 2010-09-30 Bardy Gust H Straight cutting tip for a full large bore subcutaneous implantation instrument
US20100331874A1 (en) * 2000-08-24 2010-12-30 Bardy Gust H Method for constructing an instrument with a covered bore for subcutaneous implantation
US20100331868A1 (en) * 2000-08-24 2010-12-30 Bardy Gust H Method For Constructing An Instrument With A Two-Part Plunger For Subcutaneous Implantation
US20060253065A1 (en) * 2000-08-24 2006-11-09 Bardy Gust H Instrument for implanting sensors and solid materials in a subcutaneous location and method thereof
US20100324579A1 (en) * 2000-08-24 2010-12-23 Bardy Gust H Instrument With A Covered Bore For Subcutaneous Implantation
US20070249992A1 (en) * 2000-08-24 2007-10-25 Bardy Gust H Subcutaneous implantation instrument with dissecting tool and method of construction
US20100324578A1 (en) * 2000-08-24 2010-12-23 Bardy Gust H Instrument With A Two-Part Plunger For Subcutaneous Implantation
US8251946B2 (en) 2000-08-24 2012-08-28 Cardiac Science, Inc. Method for constructing an instrument with a two-part plunger for subcutaneous implantation
US20100318022A1 (en) * 2000-08-24 2010-12-16 Bardy Gust H Straight Cutting Tip For A Straight Bore Subcutaneous Implantation Instrument
US8454552B2 (en) 2000-08-24 2013-06-04 Cardiac Science Corporation Method for constructing an instrument with a covered bore for subcutaneous implantation
US8435208B2 (en) 2000-08-24 2013-05-07 Cardiac Science Corporation Subcutaneous implantation instrument with a scissored dissecting tool assembly and method of construction
US8323232B2 (en) 2000-08-24 2012-12-04 Cardiac Science Corporation Instrument with a two-part plunger for subcutaneous implantation
US8394050B2 (en) 2000-08-24 2013-03-12 Cardiac Science Corporation Straight cutting tip for a straight bore subcutaneous implantation instrument
US7780625B2 (en) 2000-08-24 2010-08-24 Bardy Gust H Instrument for implanting sensors and solid materials in a subcutaneous location and method thereof
US20100217301A1 (en) * 2000-08-24 2010-08-26 Bardy Gust H Method For Implanting A Non-Liquid Object
US20100217298A1 (en) * 2000-08-24 2010-08-26 Bardy Gust H Subcutaneous Implantation Instrument With A Scissored Dissecting Tool Assembly And Method Of Construction
US8348882B2 (en) 2000-08-24 2013-01-08 Cardiac Science Corporation Instrument with a covered bore for subcutaneous implantation
US7736330B2 (en) 2000-08-24 2010-06-15 Bardy Gust H Subcutaneous implantation instrument with dissecting tool and method of construction
US7160325B2 (en) 2001-05-15 2007-01-09 Ams Research Corporation Implantable medical balloon and valve
US20030004534A1 (en) * 2001-06-01 2003-01-02 George Stephanie A. Balloon transporter
US6953007B1 (en) * 2002-04-03 2005-10-11 Cummings James C Pet training device
US7028640B1 (en) 2002-04-03 2006-04-18 Cummings James C Pet training device
US8062652B2 (en) 2004-06-17 2011-11-22 Endo Pharmaceuticals Solutions Inc. Compositions and methods for treating precocious puberty
US8507432B2 (en) 2005-03-11 2013-08-13 Endo Pharmaceuticals Solutions Inc. Controlled release formulations of octreotide
US20110009338A1 (en) * 2005-03-11 2011-01-13 Endo Pharmaceuticals Solutions Inc. Controlled release formulations of octreotide
US20100317579A1 (en) * 2005-03-11 2010-12-16 Endo Pharmaceuticals Solutions Inc. Controlled release formulations of octreotide
US20100247594A1 (en) * 2005-03-11 2010-09-30 Endo Pharmaceuticals Solutions Inc. Delivery of dry formulations of octreotide
US20090264813A1 (en) * 2006-06-19 2009-10-22 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US8668676B2 (en) 2006-06-19 2014-03-11 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
EP1878396A1 (en) * 2006-07-10 2008-01-16 Gust Bardy Subcutaneous implantation instrument with dissecting tool and method of construction
US9039761B2 (en) 2006-08-04 2015-05-26 Allergan, Inc. Ocular implant delivery assemblies with distal caps
US20080097335A1 (en) * 2006-08-04 2008-04-24 Allergan, Inc. Ocular implant delivery assemblies
US20080311170A1 (en) * 2007-04-27 2008-12-18 Indevus Pharmaceuticals, Inc. Implant device release agents and methods of using same
US9120249B2 (en) 2007-04-27 2015-09-01 Endo Pharmaceuticals Solutions Inc. Implant device release agents and methods of using same
US9072786B2 (en) 2008-06-25 2015-07-07 Endo Pharmaceuticals Solutions Inc. Method of manufacturing an implantable device
US20100021522A1 (en) * 2008-06-25 2010-01-28 Endo Pharmaceuticals Solutions Inc. Sustained delivery of exenatide and other peptides
US8383577B2 (en) 2008-06-25 2013-02-26 Endo Pharmaceuticals Solutions, Inc. Octreotide implant having a release agent
US20100292144A1 (en) * 2008-06-25 2010-11-18 Endo Pharmaceuticals Solutions Inc. Sustained delivery of exenatide and other peptides
US7960335B2 (en) 2008-06-25 2011-06-14 Endo Pharmaceuticals Solutions Inc. Octreotide implant having a release agent and uses thereof
US8475820B2 (en) 2008-06-25 2013-07-02 Endo Pharmaceuticals Solutions Inc. Method of manufacturing an implantable device
US20110206745A1 (en) * 2008-06-25 2011-08-25 Endo Pharmaceuticals Solutions Inc. Octreotide implant having a release agent
US8071537B2 (en) 2008-06-25 2011-12-06 Endo Pharmaceuticals Solutions Inc. Implantable device for the sustained release of a polypeptide
US20100185205A1 (en) * 2009-01-16 2010-07-22 Allergan, Inc. Interocular injector
US8545554B2 (en) 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
US9033912B2 (en) * 2012-03-28 2015-05-19 Warsaw Orthopedic, Inc. Drug delivery system
US20130261596A1 (en) * 2012-03-28 2013-10-03 Warsaw Orthopedic, Inc. Drug delivery system
US20150080845A1 (en) * 2013-03-14 2015-03-19 Allergan, Inc. Polymer system for securing implants in syringe needles

Similar Documents

Publication Publication Date Title
US3515137A (en) Intravenous catheter unit with inserter means for sequential feeding of catheter
US3537451A (en) Intravenous catheter unit with releasable inserter means
US3225762A (en) Intravenous stylet catheter
US3382872A (en) Venous catheter and needle
US3467096A (en) Multiple hypodermic syringe arrangement
US3335723A (en) Indwelling catheter unit
US3620216A (en) Implant trocar
US5052999A (en) Liposuction method and apparatus
US6213978B1 (en) Intravenous catheter insertion apparatus
US5009642A (en) Self-blunting needle assembly for use with a catheter, and catheter assembly using the same
US3599637A (en) Intravenous catheter assembly
US5085631A (en) Method and kit for administering spinal subarachnoid anesthesia
US5358474A (en) Subcutaneous drug delivery device
US5267972A (en) Hypodermic syringe with needle guard
US6450938B1 (en) Brachytherapy device
US3406687A (en) Guide and positioning means for a needle
US4909793A (en) Intravenous catheter apparatus with retractable stylet
US6726649B2 (en) Medical needle assemblies
US6053927A (en) Apparatus and method for implant removal
US5304141A (en) Method and apparatus for inducing anesthesia
Riding Post-operative Vomiting [Abridged]
US3885561A (en) Catheter
US4721506A (en) Flat-inclined tip needle
US5328480A (en) Vascular wire guiode introducer and method of use
US4732150A (en) Process for cataract extraction