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US2470297A - Inhalator - Google Patents

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Publication number
US2470297A
US2470297A US77210447A US2470297A US 2470297 A US2470297 A US 2470297A US 77210447 A US77210447 A US 77210447A US 2470297 A US2470297 A US 2470297A
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Prior art keywords
end
chamber
ball
inlet
medicament
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Expired - Lifetime
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Mack R Fields
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Abbott Laboratories
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Abbott Laboratories
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0005Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0013Details of inhalators; Constructional features thereof with inhalation check valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0018Details of inhalators; Constructional features thereof with exhalation check valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered
    • A61M15/0098Activated by exhalation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0488Mouthpieces; Means for guiding, securing or introducing the tubes
    • A61M16/049Mouthpieces
    • A61M16/0493Mouthpieces with means for protecting the tube from damage caused by the patient's teeth, e.g. bite block
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • A61M16/0666Nasal cannulas or tubing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0618Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0625Mouth

Abstract

654,872. Respiratory appliances. ABBOTT LABORATORIES. Aug. 20, 1948, No. 13228/50. Convention dates, Sept. 4, 1947 and April 30, 1948. Divided out of 654,860. [Class 81 (ii)] A container for dispensing finely divided material has a foraminated end and an external flange with radially extending lugs, remote from the foraminated end, for supporting it in a holder with the foraminated end in the path of a stream of air flowing through the said holder. The invention is described in relation to a medical device for the inhalation of powder of the type described in Specification 654,860 in which a ball 42 is raised by the suction of the patient when he inhales through a mouthpiece 48. At the top of its movement the ball 42 strikes against a cylindrical container 12 which is loosely supported in the body by its flanged end 30, so that medicated powder 14 is sprinkled through a gauze screen 16 into the air stream. The container is provided with a handle 20 and its rim has diametrically placed projections forming a bayonet catch which prevents it inadvertently falling from the body.

Description

MIY 17, 1949 M. R. FIELDS 2,470,297

INHALATOR Filed sept. 4, 1947 IN VEN TOR.

@ci Qaida Patented May 17, 1949 INHALATOR Mack R. Fields, Libertyville, lll., assigner to Abbott Laboratories, North Chicago, lll., a corporation of Illinois Application September 4, 1947, Serial No. 772,104

(Cl. 12S-266) 3 Claims. 1

My invention relates to therapeutic medication and includes among its objects and advantages increased convenience in medication with dry medicaments in powder form, especially with respect to accuracy of dosage and accurate placement of the material.

Many useful medicaments, and especially penicillin and related antibiotics, are subject to substantial or, in some instances, complete alteration by the stomach juices when administered orally. Different patients vary widely in the condition of the alimentary canal and the extent to which oral dosages will be impaired in effectiveness. In fact, the same patient will react differently to the same dosage at dilerent times, because the condition of the patients alimentary canal varies from time to time.

0n this account, precision in treatment has the general treatment thus resulting with high local concentration of the same medicament in whatever body cavity is utilized, including the lungs, and the throat, Y

In addition to Water-soluble anti-biotics, solid inhalation therapy is of value in connection with certain vasoconstrictors, and is indicated for at least some of the known anti-histamine drugs. Illustrative examples of vaso-constrictors are: epinephrine hydrochloride, isopropyl epinephrln and 2-aminoheptane.. Illustrative examples of anti-histamine agents are: N-(alpha-pyridyD- N (alpha-thenyl) N', N dimethylethylenediamine hydrochloride, and N-(alpha-pyridyl) -N- (benzyl) -N',N-dimethylethylenediamine hydrochloride.

Data available so far do not support any reliable generalizations. More particularly, the mere fact that a drug is ineffective or toxic when administered orally aiords no indication that it is suitable for solid inhalation therapy. Many such therapeutic agents which are water soluble, will be found effective by solid inhalation, but both the effect and the degree of effectiveness need to be establishd by spcic test in connection with each substance.

However, especially when the local application is in the lungs, a wide variability in the proportion of powdered material that comes to rest in the nose and in the bronchial tubes and in o0 2 the actual lung itself can only be avoided by a substantial constancy in the method of inhalation.

According to the invention, I succeed in obtaining such constancy by providing apparatus which is to be utilized by the patient by breathing in and out in a simple, substantially normal way. I utilize the energy of the -patients breathing to deliver into each charge of air inhaled a small substantially constant charge of powdered medicament, which charge is delivered quickly, shortly after inhalation begins, and nds its way to the depth of the cavity long before inhalation is finished. Thus the apparatus itself and the nose and bronchial tubesl are thoroughly swept and scavenged with pure air during a major portion of the breathing-in-process. I have found that administration in this way not only contributes to deep penetration of the medicament, but that it becomes unnecessary to pulverize or micronizev the medicament into a true smoke. The use of larger particles tends to increase the reliability with which a uniform fraction of the material will passl on through the nose and bronchial tubes without getting caught on the moist Walls.

Whereas other methods of administration by inhalation known to me are objectionable because the apparatus is expensive or complicated, or because the amount of medicament rendered effective for therapeutic purposes varies uncontrollably over a range of several hundred per cent, or both, it is possible according to the invention to work out dependable procedures which do not require hospitalization or the repeated checking of blood samples.

In the accompanying drawing:

Figure l is a side elevation of an inhalator according to the invention:

Figure 2 is a plan view of the same inhalator :from above;

Figure 3 is a plan view of the same inhalator from below;

Figure 4 is a section as on line 4-4 of Figure 2;

Figure 5 is a longitudinal section of the capsule before it is assembled with the inhalator; and

Figure 6 is a perspective` of the device in use.

In the embodiment of apparatus selected for illustration, the main housing IIJ is of transparent plastic,A molded in two halves cemented together on the plane of the section of Figure 4. The body deilnes achamberJZ having an outlet opening I4 for the discharge of air into the mouth of the patient. Flanges I6 assist the patient in holding the device in place with the teeth as partially indicated in dotted lines in Figure 1. The top opening I8 closed by a. plug 20 when it happens that medication through the mouth only is desired. Normally, it will receive a lower end of a bifurcated nose connector piece 22. This is of flexible material with its lower end ,fitted into the opening I8 and the two tips 24 entered inthe nostrils of the patient. With a suitable grade of rubber the bottom portion may advantageously have a wall thickness of about 68 thousandths of an inch, which will secure a satisfactory grip in the opening, and the wall may taper to about 30 thousandths of an inch at the end of the tip so that the tips 24 will be soft and comfortable to the users nostrils.

Means are provided for discharging a predetermined amount of powdered medicament small enough in quantity to be carried into the air-filled cavity receiving it during a first and preferably minor fraction of each breathing in, or inhalation. By making the energy requirement for the discharge of the medicament extremely low, it is possible to make this discharge, and the timing of the discharge, completely automatic, and to energize it by the energy supplied by the patient in inhaling without imposing enough burden on the muscular strength of the patient to cause any material labor or annoyance, I have illustrated a capsule 26 inserted into place in a rubber grommet 28 set in the upper wall of the body l0. The capsule, when in use, has anopen lower end obstructed by a iine screen 30. Suitable results have been obtained with screens from about 40 to 80 mesh. To jar, or agltate, the 4capsule with the right force at the right time, I provide an inlet tube 32 in which lies a ball 34 freely movable from one end of the tube to the other but restrained from falling out by a lug 36 and from falling into the chamber by a lug 38. Upon reference to Figure 4, it will be observed that the parts are so proportioned that the ball 24 may strike the capsule 28 at the end of its inward movement and thus deliver a blow to discharge powder through the screen 30.

The chamber I2 has another inlet 40 in its bottom controlled by the simple flap check valve 42. It will be apparent that at the beginning of each inhalation the ap 42 closes immediately and the suction exerted by the patient then throws the ball 34 quickly from the bottom of the tube 32 up into ycontact with the capsule 28. simple steel ballfunctions very well in this connection, but with a ball of aluminum the parts may be designed to secure a slightly better mechanical action,

The inner end of the tube 32 is provided with four slots 44 extending down the tube far enough so that the ball uncovers and opens them when it moves to the upper end of its path. Thus,` the user does not experience any material restriction on his breathing.

The capsule 26 1s filled and sealed at the place of manufacture. It may advantageously be shipped with its lower end covered with a rubber cap 46, which, in undistorted condition, has its bottom dished upward as indicated at 48 in Figure so that pushing thecap home on the lower end of the capsule will stress the bottom 48 and cause it to remain gently pressed upward against the screen 30 until the cap is removed preparatory to using the capsule.

The upper portion of the capsule is shaped for convenient handling by the user. I have illustrated a plastic capsule which may be formed initially with a middle diaphragm 50 at the top of the capsule proper 26, and substantially arcuate closed wall sections rising above the diaphragm 50 and of slightly larger diameter than that of the capsule proper 26 to dene an abutment shoulder 52 to engage the grommet 26. The

4 segmental upper portions may then be heated slightly and gently pressed over to dene an openended arch 54, the ends of which may conveniently be engaged by the finger tips of the user when inserting or withdrawing the capsule.

I prefer to curve the passage 32 in a generally arcuate path down and in toward the user to reduce the overall length of the device,

By Varying the neness of the powder and the mesh of the screen 30 various powdered medicaments can be administered at various rates. With sodium penicillin I prefer to use a screen of about 60 mesh and it is not hard to granulate the powder by trial and error to a grain size such that an administration of 100,000 units is easily accomplishedby normal breathing, in from three to six minutes. I have also found that smoother and more accurate mechanical action can be secured by mixing the penicillin with at least a little other material intended to function as a diluent or vehicle. Specifically, 100,000 units of graular penicillin represents about 90 milligrams of material and the addition to the charge of about 25 milligrams of sulfanilamide makes up into a combined powder that secures materially better and more accurate mechanical functioning. A patient inhaling such a charge will receive a full normal dose of penicillin but only about 10% of a normal dose of sulfanilamide. It will be obvious that the charge may include various combinations of medicaments with or without completely inert vehicles.

Because the energy of the users breath actuates the timed discharge, there is no other instrumentality with which any synchronism needs to be maintained. Further, because there is no extraneous power imposed on the ingoing air stream, the patients natural and normal lung movements are not disturbed and upset yby being pushed or pulled in a way that is always uncomfortable and frequently unexpected and bad l for the morale of the patient.

Others may readily adapt the invention for use under various conditions of service by empolying one or more of the novel features involved, or equivalents thereof. As at present advised with respect to the apparent scope of my invention, I desire to claim the following subject mattei'.

I claim:

1. Equipment for introducing an air-borne powdered medicament into body cavities, which comprises: a rigid transparent plastic body dening a chamber; said chamber being formed with one end outlet shaped to be gripped between the teeth of the user; said chamber having a lateral outlet positioned below the users nostrils when said first outlet is gripped by the users teeth; a flexible branched conduit having a single lower opening fitting said second chamber outlet, and double upper openings of va size to t into the nostrils of the user; said upper openings being deflnedby flexible material; a tubular inlet at the end of the chamber opposite said first outlet; a ball of diameter sufficient to substantially close said tubular inlet; said tubular inlet being inclined so that the ball normally resides at the intake end of said inlet; an obstruction at the intake end of said inlet end to prevent egress of said ball; an obstruction at the discharge end of said tubular inlet to prevent discharge of said ball into said chamber; said tubular inlet having lateral vent opening adjacent its discharge end positioned to be uncovered by said ball; a removable container for medicament;

-socket means in the wall oi said chamber for receiving and holding said container in a position to. be struck by said ball at-the end of its inward movement; said container having a foraminated bottom; and a charge of powdered medicament in said container of grain size small enough to deliver an increment of medicament through said foraminated bottom each time said ball strikes said container at the beginning of inhalation; a return flow discharge opening in said chamber, and a quick-acting check valve permitting gas to issue from said chamber during exhalation but closing at the beginning of inhalation to compel the air inhaled to enter through said tubular inlet.

2. Equipment for introducing an air-borne medicament into body cavities, which'comprises: a rigid transparent plastic body dening a chamlber; said chamber being formed with one end outlet shaped to deliver uid to the mouth of the user: said chamber having a lateral outlet positioned below the users nostrils when said rst outlet is gripped by the users teeth; a conduit means for delivering gas from said second chamber outlet into the nostrils of the user; a tubular inlet at the end of the chamber opposite said first outlet: a ball of diameter sufilcient to substantially close said tubular inlet; said tubular inlet being inclined so that the ball normally resides at the intake end of said inlet; an obstruction at the intake end of said inlet end to prevent egress of said ball; an obstruction at the discharge end of said tubular inlet to prevent discharge of said ball into said chamber; said tubular inlet having lateral vent openings adjacent its discharge end positioned to be uncovered by said ball; a removable container for medicament; socket means in the wall of said chamber for receiving said container in a position to be. struck by said ball at the end of its inward movement: said container having a foraminated bottom; and a charge of powdered -medicament in said container of grain size small enough to deliver an increment of medicament through said ioraminated bottom each time said ball strikes said container at the beginning of inhalation; a. return flow discharge opening in said chamber: and a quick-acting check valve permitting gas to issue from said chamber during exhalation but closing at the beginning of inhalation to compel .the air inhaled to enter through said tubular inlet.

3. Equipment for introducing' an airborne powdered medicament into body cavities, which comprises: a body dening 'a chamber; said chamber being formed with an outlet shaped to deliver iluid -to the person o! the user; an inlet to said chamber; a medicament container in said chamber having a foraminated Wall; means actuated by the initial flow of inhaled gas through said inlet, for jolting said container to release an increment of medicament through said i'oraminated wall; said chamber being provided with an additional outlet for the exit of gas during exhalation; and an automatic check valve in said additional outlet to prevent inward flow.

MACK R. FIELDS.

REFERENCES CITED The following references are of record in the ille of `this patent:

UNITED STATES PATENTS

US2470297A 1947-09-04 1947-09-04 Inhalator Expired - Lifetime US2470297A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US2470297A US2470297A (en) 1947-09-04 1947-09-04 Inhalator

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
BE483136A BE483136A (en) 1947-09-04 1942-06-15
US2470297A US2470297A (en) 1947-09-04 1947-09-04 Inhalator
FR967494A FR967494A (en) 1947-09-04 1948-06-10 inhaler device
FR59839E FR59839E (en) 1947-09-04 1948-06-10 inhaler device
NL141155A NL68968C (en) 1947-09-04 1948-06-24
GB2197248A GB654860A (en) 1947-09-04 1948-08-20 Improvements in or relating to therapeutic medication
GB1322850A GB654872A (en) 1947-09-04 1948-08-20 Improvements in or relating to therapeutic medication
DE1949A0012922 DE846770C (en) 1947-09-04 1949-01-01 Medikamentenbehaelter
DE1949P0030173 DE845385C (en) 1947-09-04 1949-01-01 A device for administering medicaments by inhalation
BE489055A BE489055A (en) 1947-09-04 1949-05-16

Publications (1)

Publication Number Publication Date
US2470297A true US2470297A (en) 1949-05-17

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US2470297A Expired - Lifetime US2470297A (en) 1947-09-04 1947-09-04 Inhalator

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US (1) US2470297A (en)
BE (2) BE483136A (en)
DE (2) DE846770C (en)
FR (2) FR59839E (en)
GB (2) GB654860A (en)
NL (1) NL68968C (en)

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2503732A (en) * 1949-01-28 1950-04-11 Wyeth Corp Inhalator
US2590832A (en) * 1949-03-29 1952-03-25 Frederick M Turnbull Inhaler with closure
US2641254A (en) * 1948-10-18 1953-06-09 Frederick M Turnbull Applicator
US2722935A (en) * 1949-03-22 1955-11-08 Robert E Thompson Powder dispenser
US2809634A (en) * 1956-08-07 1957-10-15 Murai Hirotada Inhaling and sniffing pipe
US3508543A (en) * 1967-04-27 1970-04-28 Orlando T Aulicono Mouth-to-mouth and nose resuscitation device
US4722326A (en) * 1985-11-04 1988-02-02 Ruderian Max J Vibratory therapeutic device
US4846168A (en) * 1986-12-05 1989-07-11 Mect Corporation Inhaler
US4886493A (en) * 1987-10-22 1989-12-12 Jordan Yee Medical applicator process
EP0626180A1 (en) 1993-05-28 1994-11-30 PAUL RITZAU PARI-WERK GmbH Mouthpiece for inhalation therapy apparatus
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5676643A (en) * 1995-02-13 1997-10-14 The Procter & Gamble Company Dispenser for friably releasing dry particulate medicaments
US5683361A (en) * 1991-12-10 1997-11-04 Novo Nordisk A/S Disposable dispenser for powder
US5797392A (en) * 1996-01-22 1998-08-25 Direct-Haler A/S Inhaler
WO1998041256A2 (en) * 1997-03-14 1998-09-24 Astra Aktiebolag (Publ) Inhalation device
US5989217A (en) * 1996-03-21 1999-11-23 Unisia Jecs Corporation Medicine administering device for nasal cavities
US6055979A (en) * 1996-04-02 2000-05-02 Ing. Erich Pfeiffer Gmbh Dosing and discharging device for flowable media including powder/air dispersions
US6065471A (en) * 1994-09-16 2000-05-23 Laboratoire Glaxo Wellcome Inhalation device
WO2000051672A1 (en) * 1999-03-03 2000-09-08 Optinose As Nasal delivery device
US6230707B1 (en) * 1993-07-30 2001-05-15 Hoerlin Ernst Powder inhaler
US20010027790A1 (en) * 2000-02-01 2001-10-11 Dura Pharmaceuticals, Inc. Dry powder inhaler
WO2002068030A2 (en) * 2001-02-26 2002-09-06 Optinose As Nasal devices
US6513519B2 (en) 1999-12-22 2003-02-04 Pari Gmbh Spezialsten Fur Effective Inhalation Inhalation atomizer with a one-piece valve element
US6606990B2 (en) 1998-01-16 2003-08-19 Pari Gmbh Spezialisten Fur Effektive Inhalation Mouth piece for inhalation therapy units
WO2003084591A1 (en) * 2002-04-04 2003-10-16 Optinose As Nasal devices
WO2003090812A2 (en) * 2002-04-25 2003-11-06 Optinose As Nasal devices
WO2004004814A2 (en) * 2002-07-02 2004-01-15 Optinose As Nasal devices
US20060054165A1 (en) * 2002-12-19 2006-03-16 Scadds Incorporated Self contained aerosol dual delivery system (SCADDS)
US20060081246A1 (en) * 2002-01-24 2006-04-20 Joachim Goede Pharmaceutical powder cartridge, and inhaler equipped with same
US20100012120A1 (en) * 2006-12-22 2010-01-21 Laboratorios Almirall, S.A. Inhalation device for drugs in powder form
WO2011151479A2 (en) * 2010-05-19 2011-12-08 Javier Ernesto Maselli Respirator - cpr resuscitation device
US20120006323A1 (en) * 2001-06-12 2012-01-12 Optinose As Nasal devices
US20130032145A1 (en) * 2008-05-01 2013-02-07 Dan Adler Dry powder inhaler
WO2014004400A2 (en) * 2012-06-28 2014-01-03 The Governt. Of The Usa As Represented By The Secretary Of The Department Of Health & Human Services Nasal dry powder delivery system for vaccines and other treatment agents
US20140096770A1 (en) * 2012-10-05 2014-04-10 Lily A. Neff Salt puffer
US20150013677A1 (en) * 2012-02-24 2015-01-15 Optinose As Nasal Delivery Devices
EP2965775A1 (en) * 2008-01-24 2016-01-13 Vectura Delivery Devices Limited Inhaler
US20160228663A1 (en) * 2014-10-27 2016-08-11 Human Design Medical, Llc Nasal mask for use in various positive airway pressure supply systems
USD776252S1 (en) * 2012-07-17 2017-01-10 Rhinosystems, Inc. Nasal irrigation device
US9883932B2 (en) 2009-10-19 2018-02-06 Aircom Manufacturing, Inc. Transdermal dispensing apparatus and methods

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1047385B (en) * 1952-03-08 1958-12-24 Armour & Co Puderzerstaeuber a removable Puderbehaelter
FI69963C (en) * 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
DK162740C (en) * 1985-08-01 1992-04-27 Wilhelm Hurka inhaler
US5176132A (en) * 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
CA2069753A1 (en) * 1990-07-27 1992-01-28 Bon Franco Del Inhalation device
CA2093809A1 (en) * 1991-08-15 1993-02-16 Bon Franco Del Inhaler
WO1994013348A1 (en) * 1992-12-11 1994-06-23 Astra Aktiebolag Inhaler
DE4319514C2 (en) * 1993-06-14 2003-06-18 Sofotec Gmbh & Co Kg powder inhaler
JP3728753B2 (en) * 1994-09-14 2005-12-21 株式会社デンソー Deodorizing filter
CN1181896C (en) * 1995-06-21 2004-12-29 索福泰克两合公司 Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
DE19522415C2 (en) * 1995-06-21 2003-12-04 Sofotec Gmbh & Co Kg Pharmaceutical powder cartridge with integrated metering and powder inhaler having means for actuating the metering device of the pharmaceutical powder cartridge
DE10202940A1 (en) 2002-01-24 2003-07-31 Sofotec Gmbh & Co Kg Cartridge for a dry powder inhaler
CN1997418B (en) 2004-07-16 2010-08-11 奥米罗有限公司 Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge system for use with this inhaler

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE471490C (en) * 1931-08-12 Rudolf Lex Apparatus for atomizing mehlfoermiger substances
US2214032A (en) * 1939-06-23 1940-09-10 Walter B Stewart Apparatus for administering powdered aluminum

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE471490C (en) * 1931-08-12 Rudolf Lex Apparatus for atomizing mehlfoermiger substances
US2214032A (en) * 1939-06-23 1940-09-10 Walter B Stewart Apparatus for administering powdered aluminum

Cited By (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2641254A (en) * 1948-10-18 1953-06-09 Frederick M Turnbull Applicator
US2503732A (en) * 1949-01-28 1950-04-11 Wyeth Corp Inhalator
US2722935A (en) * 1949-03-22 1955-11-08 Robert E Thompson Powder dispenser
US2590832A (en) * 1949-03-29 1952-03-25 Frederick M Turnbull Inhaler with closure
US2809634A (en) * 1956-08-07 1957-10-15 Murai Hirotada Inhaling and sniffing pipe
US3508543A (en) * 1967-04-27 1970-04-28 Orlando T Aulicono Mouth-to-mouth and nose resuscitation device
US4722326A (en) * 1985-11-04 1988-02-02 Ruderian Max J Vibratory therapeutic device
US4846168A (en) * 1986-12-05 1989-07-11 Mect Corporation Inhaler
US4886493A (en) * 1987-10-22 1989-12-12 Jordan Yee Medical applicator process
US5683361A (en) * 1991-12-10 1997-11-04 Novo Nordisk A/S Disposable dispenser for powder
EP0626180A1 (en) 1993-05-28 1994-11-30 PAUL RITZAU PARI-WERK GmbH Mouthpiece for inhalation therapy apparatus
US6230707B1 (en) * 1993-07-30 2001-05-15 Hoerlin Ernst Powder inhaler
US6065471A (en) * 1994-09-16 2000-05-23 Laboratoire Glaxo Wellcome Inhalation device
US6484718B1 (en) * 1994-09-16 2002-11-26 Laboratoire Glaxo Wellcome Inhalation device
US6220243B1 (en) 1994-09-16 2001-04-24 Laboratoire Glaxo Wellcome Inhalation device
US5676643A (en) * 1995-02-13 1997-10-14 The Procter & Gamble Company Dispenser for friably releasing dry particulate medicaments
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5797392A (en) * 1996-01-22 1998-08-25 Direct-Haler A/S Inhaler
US5989217A (en) * 1996-03-21 1999-11-23 Unisia Jecs Corporation Medicine administering device for nasal cavities
US6055979A (en) * 1996-04-02 2000-05-02 Ing. Erich Pfeiffer Gmbh Dosing and discharging device for flowable media including powder/air dispersions
US6655380B1 (en) 1997-03-14 2003-12-02 Astrazeneca Ab Inhalation device
WO1998041256A3 (en) * 1997-03-14 1999-02-11 Astra Ab Inhalation device
EP1454647A2 (en) * 1997-03-14 2004-09-08 AstraZeneca AB Inhalation device
US7228860B2 (en) 1997-03-14 2007-06-12 Astrazeneca Ab Inhaler with vibrational powder dislodgement
US20080092886A1 (en) * 1997-03-14 2008-04-24 Astrazeneca Ab, A Sodertalje Sweden Corporation Inhalation device
WO1998041256A2 (en) * 1997-03-14 1998-09-24 Astra Aktiebolag (Publ) Inhalation device
US20050194008A1 (en) * 1997-03-14 2005-09-08 Astrazeneca Ab, A Swedish Corporation Inhalation device
US20040065325A1 (en) * 1997-03-14 2004-04-08 Astrazeneca Ab, A Swedish Corporaion Inhalation device
US7779836B2 (en) 1997-03-14 2010-08-24 Astrazeneca Ab Inhalation device
US7841340B2 (en) 1997-03-14 2010-11-30 Astrazeneca Ab Inhaler with powder dislodging member
EP1454647A3 (en) * 1997-03-14 2004-11-17 AstraZeneca AB Inhalation device
US6606990B2 (en) 1998-01-16 2003-08-19 Pari Gmbh Spezialisten Fur Effektive Inhalation Mouth piece for inhalation therapy units
EP2332603A3 (en) * 1999-03-03 2011-10-19 Optinose AS Nasal delivery device
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US20040182388A1 (en) * 1999-03-03 2004-09-23 Djupesland Per Gisle Nasal delivery method
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US20060219240A1 (en) * 1999-03-03 2006-10-05 Djupesland Per G Nasal delivery device
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US6513519B2 (en) 1999-12-22 2003-02-04 Pari Gmbh Spezialsten Fur Effective Inhalation Inhalation atomizer with a one-piece valve element
US20090084380A1 (en) * 2000-02-01 2009-04-02 Gieschen Andrew W Dry powder inhaler
US6715486B2 (en) * 2000-02-01 2004-04-06 Quadrant Technologies Limited Dry powder inhaler
US6427688B1 (en) 2000-02-01 2002-08-06 Dura Pharmaceuticals, Icn. Dry powder inhaler
US6971384B2 (en) 2000-02-01 2005-12-06 Quadrant Technologies Limited Dry powder inhaler
US20040163644A1 (en) * 2000-02-01 2004-08-26 Gieschen Andrew W. Dry powder inhaler
US20010027790A1 (en) * 2000-02-01 2001-10-11 Dura Pharmaceuticals, Inc. Dry powder inhaler
US7958890B2 (en) 2000-02-01 2011-06-14 Quadrant Technologies Limited Dry powder inhaler
US20040112378A1 (en) * 2001-01-26 2004-06-17 Djupesland Per Gisle Nasal devices
WO2002068030A2 (en) * 2001-02-26 2002-09-06 Optinose As Nasal devices
US8522778B2 (en) 2001-02-26 2013-09-03 Optinose As Nasal devices
US7740014B2 (en) 2001-02-26 2010-06-22 Optinose As Nasal devices
WO2002068030A3 (en) * 2001-02-26 2003-02-06 Optinose As Nasal devices
US20110088691A1 (en) * 2001-02-26 2011-04-21 Per Gisle Djupesland Nasal Devices
US9205208B2 (en) * 2001-06-12 2015-12-08 Optinose As Nasal devices
US20120006323A1 (en) * 2001-06-12 2012-01-12 Optinose As Nasal devices
US20060081246A1 (en) * 2002-01-24 2006-04-20 Joachim Goede Pharmaceutical powder cartridge, and inhaler equipped with same
US7954492B2 (en) 2002-01-24 2011-06-07 Almirall, S.A. Pharmaceutical powder cartridge, and inhaler equipped with same
WO2003084591A1 (en) * 2002-04-04 2003-10-16 Optinose As Nasal devices
US7854227B2 (en) 2002-04-25 2010-12-21 Optinose As Nasal devices
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US20060096589A1 (en) * 2002-04-25 2006-05-11 Djupesland Per G Nasal devices
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US20060107957A1 (en) * 2002-07-02 2006-05-25 Djupesland Per G Nasal devices
WO2004004814A2 (en) * 2002-07-02 2004-01-15 Optinose As Nasal devices
US20090101146A1 (en) * 2002-07-02 2009-04-23 Per Gisle Djupesland Nasal devices
WO2004004814A3 (en) * 2002-07-02 2004-05-21 Optinose As Nasal devices
US20060054165A1 (en) * 2002-12-19 2006-03-16 Scadds Incorporated Self contained aerosol dual delivery system (SCADDS)
US7913686B2 (en) * 2002-12-19 2011-03-29 Scadds Incorporated Self contained aerosol dual delivery system (SCADDS)
US8567394B2 (en) 2006-12-22 2013-10-29 Almirall, S.A. Inhalation device for drugs in powder form
US20100012120A1 (en) * 2006-12-22 2010-01-21 Laboratorios Almirall, S.A. Inhalation device for drugs in powder form
US9295792B2 (en) 2008-01-24 2016-03-29 Vectura Delivery Devices Limited Inhaler
EP2965775A1 (en) * 2008-01-24 2016-01-13 Vectura Delivery Devices Limited Inhaler
US20130032145A1 (en) * 2008-05-01 2013-02-07 Dan Adler Dry powder inhaler
US9883932B2 (en) 2009-10-19 2018-02-06 Aircom Manufacturing, Inc. Transdermal dispensing apparatus and methods
WO2011151479A2 (en) * 2010-05-19 2011-12-08 Javier Ernesto Maselli Respirator - cpr resuscitation device
WO2011151479A3 (en) * 2010-05-19 2012-03-08 Javier Ernesto Maselli Respirator - cpr resuscitation device
US20150013677A1 (en) * 2012-02-24 2015-01-15 Optinose As Nasal Delivery Devices
CN104470569A (en) * 2012-06-28 2015-03-25 美国政府(由卫生和人类服务部的部长所代表) Nasal dry powder delivery system for vaccines and other treatment agents
WO2014004400A3 (en) * 2012-06-28 2014-04-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nasal dry powder delivery system for vaccines and other treatment agents
WO2014004400A2 (en) * 2012-06-28 2014-01-03 The Governt. Of The Usa As Represented By The Secretary Of The Department Of Health & Human Services Nasal dry powder delivery system for vaccines and other treatment agents
USD776252S1 (en) * 2012-07-17 2017-01-10 Rhinosystems, Inc. Nasal irrigation device
US9764103B2 (en) * 2012-10-05 2017-09-19 Lily A. Neff Salt puffer
US20140096770A1 (en) * 2012-10-05 2014-04-10 Lily A. Neff Salt puffer
US20160228663A1 (en) * 2014-10-27 2016-08-11 Human Design Medical, Llc Nasal mask for use in various positive airway pressure supply systems

Also Published As

Publication number Publication date Type
GB654872A (en) 1951-07-04 application
NL68968C (en) 1951-06-15 grant
BE483136A (en) 1942-06-30 grant
GB654860A (en) 1951-07-04 application
DE846770C (en) 1952-08-18 grant
BE489055A (en) 1949-06-15 grant
FR967494A (en) 1950-11-03 grant
FR59839E (en) 1954-08-23 grant
DE845385C (en) 1952-11-04 grant

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