US2222371A - Liquid withdrawal and dispensing means - Google Patents

Liquid withdrawal and dispensing means Download PDF

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Publication number
US2222371A
US2222371A US216140A US21614038A US2222371A US 2222371 A US2222371 A US 2222371A US 216140 A US216140 A US 216140A US 21614038 A US21614038 A US 21614038A US 2222371 A US2222371 A US 2222371A
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United States
Prior art keywords
container
blood
seal
closure
clamp
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Expired - Lifetime
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US216140A
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Naurice M Nesset
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Baxter International Inc
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Baxter Laboratories Inc
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/002Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00Bottles and jars
    • Y10S215/03Medical

Definitions

  • This invention relates to liquid Withdrawal and dispensing means. It is particularly -useful in the withdrawal of blood, and the storing and dispensing of the same.
  • An object of the invention is to provide extremely simple mechanism and means whereby liquids may be withdrawn and,A stored in steriler condition and later lemployed as parenteral liquids.
  • a further object is to provide a blood lo transfusion set or bank whereby blood may be withdrawn and stored and later injected, a single container being employed and the liquid being maintained in sterile condition.
  • Figure 1 is a plan view of a container and closure embodying my invention
  • Fig. 2 a vertical sectional view, the section being taken as indicated at line 2 of Fig. 1
  • Fig. 3 a view similar to Fig. 2 but showing a portion of the closure being removed
  • Fig. 4 a View similar toFig.
  • apparatus for the transfusion of blood employ vacuum within a container, the vacuum being pro- 35 pokerd and maintained through the use of various devices connected with the closure of the container.
  • Such devices have to be manipulated during the blood withdrawal operation for the maintenance of the vacuum while at the same 40 time the physician must move the container continuously in a circular or other motion for the mixing of the blood with citrate or some other anti-coagulant.
  • additional apparatus must be kept sterile and there 45 is always a danger that unsterile surfaces may be brought into communication with the interior of the container.
  • I dispense entirely with such vacuum drawing means and 50 employ only an evacuated container which. is maintained s terile by outer closure means until its use is desired.
  • the outer closurel is then removed and blood is withdrawn through needle mechanism employed with the inner closure 55 member in combination with means for controlling the rate of iniiow of blood.
  • the closure in this form after the withdrawal of the needle from the closure, serves to automatically seal the container and the withdrawn blood may then be stored for substantial periods of time.
  • the inner closure may be partially removed to permit the application of the Withdrawal tube to the closure member.
  • A designates 25 a container; B, a resilient closure for the neck of the container; and C, removable sealing means. l
  • the container A may be of. any suitable type.
  • the glass container which is partially illustrated, is of the type shown in Baxter Patent No. 2,004,027, the bottom of the container being equipped with a supporting bail member (not shown) by which the container can be supported in inverted position for the with- I drawal of liquids.
  • the neck of the bottle A is provided with threads I0.
  • the closure B may 'be of any suitable con-- struction and resilient material. I prefer to em- 40 ploy a resilient rubber material which is quite elastic and forms a good seal with the neck of the container A.
  • the plug B is provided in its upper side with an integral ange Il which rests uponthe top of the container neck.
  • the plug B is provided With an air intake passage l2 through which extends a glass tube I3. The tube extends almost to the bottom of the container.
  • a liquid withdrawal passage Hl also extends through the plug B and is adapted to receive a glass coupling member to which a tube is secured leading to the injection needle.
  • sealing means C may also be of any suitable construction.
  • I provide a thin exible and resilient sealing member I5 directly over the plug B. 'This serves to seal the openings I2 and I4. The seal I5 is maintained against plug B, and also plug B is thereby maintained in position within the co g the bottle neck, and clamp I6 may be retained.
  • the inner iiexible seal I5 could be removed by tearing it and, if desired, a portion of clamp I6 may be-cut away along its upper flange to facilitate the grasping of the seal I5 to aid in its removal.
  • I have shown the inner clamp I6 removable, a tear flap I1 being provided whereby a strip may be torn vertically along the sides of the clamp to separate it so Vthat it can be then drawnl off the container neck.
  • clamp I6 I provide another resilient seal I8 which is identical to seal I5 and which provides an uncontaminated and sterile surface so thatthe sterile hollow needle may be passed through plug B without becoming contaminated and thus obviating the danger of contaminating the interior of the container.
  • seal I8 is a metal disk I9 and above the disk I9 is an outer clamp or cap 20.
  • the outer cap 20 is provided with a tear tab 2I, similar to the tab I1 with which the inner clamp I6 is provided.
  • cap 20 has its lower portion spun about the lower bead of the threads I0 so as to confine it in position.
  • a hollow needle ⁇ 22 is employed, the needle being provided with winged members 23, and a tube 24 connects the needle 22 to the injection .needle V25.
  • a clamp 26 is provided adjacent needle 25 or adjacent needle 23 for closing the tube and also for partially opening it to control the iiow of blood therethrough, the clamp being preferably provided with a ne adjustment screw whereby accurate control can be maintained.
  • I provide a screw cap 2l which can be threaded on the neck of the bottle A so as to confine the closure member B in position. In this position a dispensing tube is connected by means of a coupling member to the outlet passage I4 of the plug B.
  • the seal I5Y maintains the openings I4 and I2 closed so that a very tight vacuum is maintained within the container:
  • the clamp I6 is then spun into position so as to confine the seal I5 in the position shown.
  • I place the second seal I8 above the ange of clamp I6 When it is desired to use the apparatus in a blood transfusion operation, the physician draws the tear tab 2l so as to release the outer cap 20.
  • clamp 26 is then opened slightly to permit the blood to flow into the container at the desired rate.
  • I maintain a desired small amount of .citrate in the container A, being placed there before the evacuation of the bottle so that as the blood enters the container, the container can be moved in a circular or other direction to mix the blood with the anti-coagulant, or the anti-coagulant may be added to vthe evacuated container by the operator using the needle assembly asin drawing blood.
  • the clamp 26 is set to close the tube 24 and the needle 25 is withdrawn from the donor. As the needle 22 is withdrawn, the resilient plug B immediately closes the opening caused by the needle so as to form an airtight closure.
  • the seal I5 closes the opening formerly made by the needle 22. At the same time, the seal I5 maintains its closure of the openings I2 and I4, the seal being effective not only by the partial vacuum which remains in the container but also by the clamp I6.
  • the container may now be set in a cold place or otherwise preserved until ⁇ it is desired to dispense the blood, or the blood maybe given at once.
  • the inner clamp I6 is removed by drawing the tear tab l'I and the seal I5 lifted o iT. Cap 21 is then screwed in place, as shown more clearly in Fig. 4.
  • the withdrawal tube may then be connected to passage I4 by a glass coupling member and, upon the inversion of the container A as described more fully in Baxter Patent No. 2,004,027,
  • the blood may be injected.
  • ity Prior to injection, ity
  • sterile surfaces provided by the container, one sterile surface being outermost and protecting the apparatus up to the time when blood is to be withdrawn'.
  • the second sterile surface is provided by inner seal I5 which is effective during the withdrawal of blood and the preserving of the same up to the time when the blood is to be injected.
  • a container having an opening, a resilient closure for said opening, said closure being provided with at least one passage therethrough, a resilient seal over said closure, said container being evacuated and being maintained under vacuum by said seal, a clamp member conning said seal upon said closure, a second seal above said clamp, and cap closure means about said outer seal.
  • va partially evacuated container having a neck, a resilient closure for said neck, said closure being provided with at least one passage therethrough, sealing means over said closure, and a cap secured to said neck and enclosing said sealing means, said sealing means consisting of two separable resilient lms over said closure and means engaging thecontainer neck for maintaining one 0f said lms in sealing position after the cap has been removed.

Description

, Nov. 19, 1940. N. M. NEssET LIQUID WITHDRAWAL AND DISPEIIJSING MEANS Filed June 27, 1958 w aw Patented Nov. 19, 1940 UNTTED .STATE-'s 2,222,371 LIQUID WITHDRAWAL AND DISPENSING MEANS Naurice M. Nesset, Glenview, Ill., assigner to Baxter Laboratories, Inc., Glenview, Ill., a corporation of Delaware Applicaacn June 27, 193s. serial No. 216,140
s claims.- -(Ci. 12s- 214) This invention relates to liquid Withdrawal and dispensing means. It is particularly -useful in the withdrawal of blood, and the storing and dispensing of the same.
An object of the invention is to provide extremely simple mechanism and means whereby liquids may be withdrawn and,A stored in steriler condition and later lemployed as parenteral liquids. A further object is to provide a blood lo transfusion set or bank whereby blood may be withdrawn and stored and later injected, a single container being employed and the liquid being maintained in sterile condition. Other specific objects and advantages Will appear as the specilication proceeds.
The invention is illustrated, in a preferred embodiment, by the accompanying drawing, in whichv Figure 1 is a plan view of a container and closure embodying my invention; Fig. 2, a vertical sectional view, the section being taken as indicated at line 2 of Fig. 1; Fig. 3, a view similar to Fig. 2 but showing a portion of the closure being removed; and Fig. 4, a View similar toFig.
2 but showing the cap and sealing members removed and the closure ready for the application of the liquid dispensing or injecting apparatus.
While the invention is applicable for the withdrawal and dispensing of liquids, for lthe purpose 3G of clearness it`wil1 be described herein in connection with the transfusion of blood.
Heretofore, it has been proposed that apparatus for the transfusion of blood employ vacuum within a container, the vacuum being pro- 35 duced and maintained through the use of various devices connected with the closure of the container. Such devices have to be manipulated during the blood withdrawal operation for the maintenance of the vacuum while at the same 40 time the physician must move the container continuously in a circular or other motion for the mixing of the blood with citrate or some other anti-coagulant. Furthermore, such additional apparatus must be kept sterile and there 45 is always a danger that unsterile surfaces may be brought into communication with the interior of the container.
'In the apparatus disclosed herein, I dispense entirely with such vacuum drawing means and 50 employ only an evacuated container which. is maintained s terile by outer closure means until its use is desired. The outer closurel is then removed and blood is withdrawn through needle mechanism employed with the inner closure 55 member in combination with means for controlling the rate of iniiow of blood. The closure in this form, after the withdrawal of the needle from the closure, serves to automatically seal the container and the withdrawn blood may then be stored for substantial periods of time. When it 5 is desired to inject the blood, the inner closure may be partially removed to permit the application of the Withdrawal tube to the closure member. With this arrangement, it will be observed 'that a single container is employed, that no vac- 10 uum withdrawal means is necessary, that the physician after setting the control member for the desired rate of iiow of blood has both hands free for manipulating the container for mixing the blood with the citrate. It will be further 15 noted that two sterile surfaces are provided, one surface being employed for keeping the entire container sterile up to the time when the withdrawal of blood is desired, and that the second surface is effective after the Withdrawal of 'the 20 blood and up to the time that the blood is to be injected. .'By this arrangement, the apparatus is reduced to the utmost in simplicity-and ease of operation. l
In the specific illustration given, A designates 25 a container; B, a resilient closure for the neck of the container; and C, removable sealing means. l
The container A may be of. any suitable type. In the illustration given, the glass container, which is partially illustrated, is of the type shown in Baxter Patent No. 2,004,027, the bottom of the container being equipped with a supporting bail member (not shown) by which the container can be supported in inverted position for the with- I drawal of liquids.
The neck of the bottle A is provided with threads I0.
The closure B may 'be of any suitable con-- struction and resilient material. I prefer to em- 40 ploy a resilient rubber material which is quite elastic and forms a good seal with the neck of the container A. The plug B is provided in its upper side with an integral ange Il which rests uponthe top of the container neck. The plug B is provided With an air intake passage l2 through which extends a glass tube I3. The tube extends almost to the bottom of the container. A liquid withdrawal passage Hl also extends through the plug B and is adapted to receive a glass coupling member to which a tube is secured leading to the injection needle.
'I'he sealing means C may also be of any suitable construction. In the illustration given, I provide a thin exible and resilient sealing member I5 directly over the plug B. 'This serves to seal the openings I2 and I4. The seal I5 is maintained against plug B, and also plug B is thereby maintained in position within the co g the bottle neck, and clamp I6 may be retained.
as a permanent part of the closure. With this construction, the inner iiexible seal I5 could be removed by tearing it and, if desired, a portion of clamp I6 may be-cut away along its upper flange to facilitate the grasping of the seal I5 to aid in its removal. In the specific illustration given, I have shown the inner clamp I6 removable, a tear flap I1 being provided whereby a strip may be torn vertically along the sides of the clamp to separate it so Vthat it can be then drawnl off the container neck.
Above the clamp I6 I provide another resilient seal I8 which is identical to seal I5 and which provides an uncontaminated and sterile surface so thatthe sterile hollow needle may be passed through plug B without becoming contaminated and thus obviating the danger of contaminating the interior of the container. Above the seal I8 is a metal disk I9 and above the disk I9 is an outer clamp or cap 20. The outer cap 20 is provided with a tear tab 2I, similar to the tab I1 with which the inner clamp I6 is provided. The
cap 20 has its lower portion spun about the lower bead of the threads I0 so as to confine it in position.
For the introduction of blood in the container, a hollow needle `22 is employed, the needle being provided with winged members 23, and a tube 24 connects the needle 22 to the injection .needle V25. A clamp 26 is provided adjacent needle 25 or adjacent needle 23 for closing the tube and also for partially opening it to control the iiow of blood therethrough, the clamp being preferably provided with a ne adjustment screw whereby accurate control can be maintained.
In the dispensing of the blood, I provide a screw cap 2l which can be threaded on the neck of the bottle A so as to confine the closure member B in position. In this position a dispensing tube is connected by means of a coupling member to the outlet passage I4 of the plug B.
Operation In the operation of the apparatus, I place the seal I5 upon the closure member B and draw a vacuum within the container preferably in accordance with the method described more fully in Baxter Patent No. 2,004,027. Upon removal of the container from the vacuum drawing ap paratus, the seal I5Y maintains the openings I4 and I2 closed so that a very tight vacuum is maintained within the container: The clamp I6 is then spun into position so as to confine the seal I5 in the position shown. Next, I place the second seal I8 above the ange of clamp I6 When it is desired to use the apparatus in a blood transfusion operation, the physician draws the tear tab 2l so as to release the outer cap 20. When the cap is removed,l the disk I9 and outer seal I8 are taken oil so as to provide the structure shown in Fig. 3. The needle 22 is then thrust through the resilient closure B, the outer end of tube 24 being maintained in closed position by the clamp 26. Needle 25 is injected into the vein in the usual manner. The
clamp 26 is then opened slightly to permit the blood to flow into the container at the desired rate. In the preferred practice, I maintain a desired small amount of .citrate in the container A, being placed there before the evacuation of the bottle so that as the blood enters the container, the container can be moved in a circular or other direction to mix the blood with the anti-coagulant, or the anti-coagulant may be added to vthe evacuated container by the operator using the needle assembly asin drawing blood. After the desired amount of blood has bee'n drawn, the clamp 26 is set to close the tube 24 and the needle 25 is withdrawn from the donor. As the needle 22 is withdrawn, the resilient plug B immediately closes the opening caused by the needle so as to form an airtight closure. Likewise, the seal I5 closes the opening formerly made by the needle 22. At the same time, the seal I5 maintains its closure of the openings I2 and I4, the seal being effective not only by the partial vacuum which remains in the container but also by the clamp I6.
The container, as just described, may now be set in a cold place or otherwise preserved until `it is desired to dispense the blood, or the blood maybe given at once. In the specific illustration given, the inner clamp I6 is removed by drawing the tear tab l'I and the seal I5 lifted o iT. Cap 21 is then screwed in place, as shown more clearly in Fig. 4. The withdrawal tube may then be connected to passage I4 by a glass coupling member and, upon the inversion of the container A as described more fully in Baxter Patent No. 2,004,027,
the blood may be injected. Prior to injection, ity
will be understood that the temperature of the blood will be raised to the point desired.
From the foregoing description, it will be observed that there aretwo sterile surfaces provided by the container, one sterile surface being outermost and protecting the apparatus up to the time when blood is to be withdrawn'. The second sterile surface is provided by inner seal I5 which is effective during the withdrawal of blood and the preserving of the same up to the time when the blood is to be injected. By this means, a single container may be employed for the entire blood transfusion operation and no apparatus other than the container itself need be employed.
While in the illustration given, I have shown a clamp 26 for controlling the i'low of blood, it will be understood that a graduated valve or other control means may be employed for en-v abling the physician to accurately control the rate of iiow. Other changes may be readily made in the structure Without departing from the spirit of my invention. The form of the cap andthe clamp and the sealing mechanism may` obviously be considerably modiiied by those skilled in the art. f f
'Ihe foregoing detailed description has been given for clearness of understandingl only, and no unnecessary limitations should be understood therefrom, but the appended claims should be construed as broadly as permissible, in view of the prior art.
I claim:
1. In combination, a container having an opening, a resilient closure for said opening, said closure being provided with at least one passage therethrough, a resilient seal over said closure, said container being evacuated and being maintained under vacuum by said seal, a clamp member conning said seal upon said closure, a second seal above said clamp, and cap closure means about said outer seal.
2. In combination with a-container having an tained under vacuum by said seal, a clamp member engaging the neck of said container and conning said seal against saidplug, a second'resilient seal over said clamp, a metal disk over said second seal, and a removable cap conning said disk over said second seal.
3. In combination, va partially evacuated container having a neck, a resilient closure for said neck, said closure being provided with at least one passage therethrough, sealing means over said closure, and a cap secured to said neck and enclosing said sealing means, said sealing means consisting of two separable resilient lms over said closure and means engaging thecontainer neck for maintaining one 0f said lms in sealing position after the cap has been removed. y
' NAURICE M. NESSET.
US216140A 1938-06-27 1938-06-27 Liquid withdrawal and dispensing means Expired - Lifetime US2222371A (en)

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2421313A (en) * 1941-12-12 1947-05-27 Baxter Laboratories Inc Closure for containers
US2457120A (en) * 1944-11-28 1948-12-28 Baxter Laboratories Inc Container and method of using same
US2461558A (en) * 1945-12-15 1949-02-15 James E Meagher Transfusion apparatus
US2594639A (en) * 1950-05-22 1952-04-29 Baxter Don Inc Y rubber stopper
US2647513A (en) * 1951-03-28 1953-08-04 Armour & Co Lyophilzation container
US2665024A (en) * 1951-01-15 1954-01-05 Baxter Don Inc Pharmaceutical closure
US2680531A (en) * 1951-05-28 1954-06-08 West Co Cap structure for bottles
US2689562A (en) * 1951-05-15 1954-09-21 Becton Dickinson Co Blood donor assembly
US2689564A (en) * 1951-11-29 1954-09-21 Becton Dickinson Co Blood donor assembly
US2770234A (en) * 1954-04-05 1956-11-13 Baxter Laboratories Inc Parenteral administration of liquids
US3017050A (en) * 1955-01-10 1962-01-16 Sr Courtland H Barr Blood sample collection apparatus
US3047178A (en) * 1958-06-24 1962-07-31 Baxter Laboratories Inc Closure system
US3480171A (en) * 1966-12-30 1969-11-25 West Co Container closure
US3792794A (en) * 1971-10-04 1974-02-19 Cutter Lab Closure for containers
US20170101227A1 (en) * 2015-10-13 2017-04-13 Nomacorc Llc Closure for a product retaining container

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2421313A (en) * 1941-12-12 1947-05-27 Baxter Laboratories Inc Closure for containers
US2457120A (en) * 1944-11-28 1948-12-28 Baxter Laboratories Inc Container and method of using same
US2461558A (en) * 1945-12-15 1949-02-15 James E Meagher Transfusion apparatus
US2594639A (en) * 1950-05-22 1952-04-29 Baxter Don Inc Y rubber stopper
US2665024A (en) * 1951-01-15 1954-01-05 Baxter Don Inc Pharmaceutical closure
US2647513A (en) * 1951-03-28 1953-08-04 Armour & Co Lyophilzation container
US2689562A (en) * 1951-05-15 1954-09-21 Becton Dickinson Co Blood donor assembly
US2680531A (en) * 1951-05-28 1954-06-08 West Co Cap structure for bottles
US2689564A (en) * 1951-11-29 1954-09-21 Becton Dickinson Co Blood donor assembly
US2770234A (en) * 1954-04-05 1956-11-13 Baxter Laboratories Inc Parenteral administration of liquids
US3017050A (en) * 1955-01-10 1962-01-16 Sr Courtland H Barr Blood sample collection apparatus
US3047178A (en) * 1958-06-24 1962-07-31 Baxter Laboratories Inc Closure system
US3480171A (en) * 1966-12-30 1969-11-25 West Co Container closure
US3792794A (en) * 1971-10-04 1974-02-19 Cutter Lab Closure for containers
US20170101227A1 (en) * 2015-10-13 2017-04-13 Nomacorc Llc Closure for a product retaining container

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