US2183493A - Germicidal and antiseptic composition - Google Patents
Germicidal and antiseptic composition Download PDFInfo
- Publication number
- US2183493A US2183493A US61113A US6111336A US2183493A US 2183493 A US2183493 A US 2183493A US 61113 A US61113 A US 61113A US 6111336 A US6111336 A US 6111336A US 2183493 A US2183493 A US 2183493A
- Authority
- US
- United States
- Prior art keywords
- acid
- germicidal
- phenylmercuric
- solution
- tribasic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002070 germicidal effect Effects 0.000 title description 7
- 239000000203 mixture Substances 0.000 title description 7
- 230000002421 anti-septic effect Effects 0.000 title description 3
- 239000000243 solution Substances 0.000 description 16
- 239000002253 acid Substances 0.000 description 14
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 12
- 239000004327 boric acid Substances 0.000 description 12
- 239000004135 Bone phosphate Substances 0.000 description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 8
- 150000007522 mineralic acids Chemical class 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 5
- 229910002651 NO3 Inorganic materials 0.000 description 4
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000002085 irritant Substances 0.000 description 3
- 231100000021 irritant Toxicity 0.000 description 3
- 230000000622 irritating effect Effects 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229940008718 metallic mercury Drugs 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 150000001450 anions Chemical group 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- DCNLOVYDMCVNRZ-UHFFFAOYSA-N phenylmercury(.) Chemical class [Hg]C1=CC=CC=C1 DCNLOVYDMCVNRZ-UHFFFAOYSA-N 0.000 description 1
- MSYUMXXVCSLXMR-UHFFFAOYSA-N phenylmercury;hydrate Chemical compound O.[Hg]C1=CC=CC=C1 MSYUMXXVCSLXMR-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46D—MANUFACTURE OF BRUSHES
- A46D9/00—Machines for finishing brushes
- A46D9/06—Impregnating
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
Definitions
- This invention relates to germicidal and antiseptic compositions; and it comprises composi- .tions containing a phenylmercuric radical and free tribasic inorganic acid such as boric or phos- 5 phoric acid;
- Phenylmercuric compounds are among the most powertul germicldes known. And in general they have asurprisingly small irritant effect on the skln,;eve,n with solutions of rather high concentration. There is, however, some irritant tendency and with a sensitive skin or sensitive tissue it must be taken into consideration' In extreme cases, burns or blisters have been produced on the skin by the use of unduly concengg trated solutions for prolonged periods, necessitating the use of weakersolutions. Further, solu-. tions of phenylmercuric compounds, while quite stable are not indefinitely so; many on long standing, that is, in a few months, undergo ingo ternal changes which may result in a separation of metallic mercury. The same class of changes occur in considerably less time, at a temperature of 100 C.
- the present invention is applicable to phenyl- 30 mercuric compounds of the general type, CBHSHgX, wherein X is an anion.
- phenylmercuric compounds particularly useful as geimicides embraced in the present invention may be listed the hydroxide, the basic nitrate, the
- the tribasic inorganic acid to be used is generally phosphoric acid or boric acid; boric acid being particularly desirable.
- the phenylmercuric compound is a hydroxide
- the tribasic acid used may not be wholly in a free state since, for example, the boric acid may be partially neutralized with soda and monosodium phosphate (an acid phosphate) may be employed in equivalent amounts, in lieu of the free acid.
- the present improvement is useful with nonaqueous germicidal compositions containing phenylmercury compounds as well as aqueous, as for I instance with liquids containing alcohol, glycerine, glycol, etc. It is also useful with salves; for as example 1 part phenylmercuric basic nitrate, 1.5 parts boric acid in 1500 parts of an ointment having an oxycholesterin base has proved highly satisfactory.
- An improved germicidal preparation consisting of a solution of a phenyl mercuric salt and a tribasic inorganic acid, said tribasic inorganic acid being present in greater proportion thanv the phenyl mercuric salt, and in an amount sufficient to stabilize the phenyl mercuric salt against deterioration by age.
- composition of claim 1 in which the acid is phosphoric acid is phosphoric acid.
- composition of claim 1 in which the phenyl mercuric salt is a salt of a tribasic inorganic acid.
- An improved germicidal preparation conmes es sisting of a solution of a phenyl mercuric salt of a tribasic inorganic acid. and an acid inorganic salt of a tribaslc inorganic acid, said acid tribasic salt being present in greater proportion than.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Description
Patented Dec. 12, 193
Mahlon I. Rentschler,
- oman AND ANTISEPTIC COOS!- TION Wilioughby, and Donald B. Bradner, Hamilton, Ohio, assignors to The Hamilton Laboratories, Inc., Hamilton, Ohio, a corporation of Delaware Application January 2'], 1936,
Serial No. 61,113
5 Claims. This invention relates to germicidal and antiseptic compositions; and it comprises composi- .tions containing a phenylmercuric radical and free tribasic inorganic acid such as boric or phos- 5 phoric acid;
Phenylmercuric compounds are among the most powertul germicldes known. And in general they have asurprisingly small irritant effect on the skln,;eve,n with solutions of rather high concentration. There is, however, some irritant tendency and with a sensitive skin or sensitive tissue it must be taken into consideration' In extreme cases, burns or blisters have been produced on the skin by the use of unduly concengg trated solutions for prolonged periods, necessitating the use of weakersolutions. Further, solu-. tions of phenylmercuric compounds, while quite stable are not indefinitely so; many on long standing, that is, in a few months, undergo ingo ternal changes which may result in a separation of metallic mercury. The same class of changes occur in considerably less time, at a temperature of 100 C.
We have found that the irritant efiect of even as strong solutions of these compounds may be greatly reduced and the stability greatly increased by the use of a little inorganic tribasic acid in the solution as such.
The present invention is applicable to phenyl- 30 mercuric compounds of the general type, CBHSHgX, wherein X is an anion. Among the phenylmercuric compounds particularly useful as geimicides embraced in the present invention may be listed the hydroxide, the basic nitrate, the
an chlorid, the acetate, etc.
The tribasic inorganic acid to be used is generally phosphoric acid or boric acid; boric acid being particularly desirable. In the event that the phenylmercuric compound is a hydroxide,
9 which is a basic body more than enough boric acid is added to neutralize the base. The same is true in using phosphoric acid. With saline compositions of the phenylmercuric type, a little free acidity of the tribasic acid is all that 4,5 is wanted. There is evidence to show that an excess of.- acid, that is a little free acid, is in general desirable. Thus as regards the stabilizing efiect, it is found that the. addition of 0.1 per cent of boric acid to an aqueous solution, 121500 50 phenyl mercuric basic nitrate has a great stabilizlng effect. Such a solution remains stable at room temperatures indefinitely long without any visible sign of decomposition or loss of germicidal effectiveness. A similar solution, without the boric acid, will give a deposit of metallic mercury in a few months. With a simple aqueous solution, two days exposure to a temperature of 100 C. causes a deposit but with the amount of boric,acid stated present, no deposit was found even in heating as long as 18 days, in each case g using enough acid to have a little in excess. As regards reduction. of any irritant efiect upon human tissue in germicidal phenylmercuric solutions, it has been found that a large drop of 111500 solution of phenylmercuric basic nitrate, 10 containing 0.1 per cent boric acid, may be applied to the skin of the average individual and allowed to dry thereon without producing any irritation or visible mark. In drying down, of course, the solution becomes. progressively more conceni5 trated. A similar solution but without boric acid, will in many instances, and particularly with sensitive skins, develop an irritating redness; sometimes even a blister. It has been found that solutions considerably more concentrated than the 20 stated 1:1500 solution, even up to a triple concentration, when. containing boric acid and applied in this way, do not burn or irritate. As an extreme example, 1 part phenylmercurlc borate and 5 parts ordinary crystallized boric acid dissolved in 500 parts of dilute alcohol (50 per cent alcohol and 50 per cent water) may be applied to the ordinary skin without producing redness. Similarly, a solution of 1 part phenylmercuric hydroxide and 4 parts commercial g9 sirupy phosphoric acid in 1500 parts of water is not irritating. This solution contains phenylmercuric phosphate with some excess phosphoric acid.
The tribasic acid used may not be wholly in a free state since, for example, the boric acid may be partially neutralized with soda and monosodium phosphate (an acid phosphate) may be employed in equivalent amounts, in lieu of the free acid. 40
The present improvement is useful with nonaqueous germicidal compositions containing phenylmercury compounds as well as aqueous, as for I instance with liquids containing alcohol, glycerine, glycol, etc. It is also useful with salves; for as example 1 part phenylmercuric basic nitrate, 1.5 parts boric acid in 1500 parts of an ointment having an oxycholesterin base has proved highly satisfactory.
What we claim is: I
1. An improved germicidal preparation consisting of a solution of a phenyl mercuric salt and a tribasic inorganic acid, said tribasic inorganic acid being present in greater proportion thanv the phenyl mercuric salt, and in an amount sufficient to stabilize the phenyl mercuric salt against deterioration by age.
2. The composition of claim 1 in which the acid is boric acid.
3. The composition of claim 1 in which the acid is phosphoric acid.
4. The composition of claim 1 in which the phenyl mercuric salt is a salt of a tribasic inorganic acid.
5. An improved germicidal preparation conmes es sisting of a solution of a phenyl mercuric salt of a tribasic inorganic acid. and an acid inorganic salt of a tribaslc inorganic acid, said acid tribasic salt being present in greater proportion than. the
'phenyl mercuric salt, and in an amount sumcient to stabilize the phenyl mercuric salt agamst deterioration by age.
ON J. RENISCBEER. DUNALD E.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61113A US2183493A (en) | 1936-01-27 | 1936-01-27 | Germicidal and antiseptic composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61113A US2183493A (en) | 1936-01-27 | 1936-01-27 | Germicidal and antiseptic composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US2183493A true US2183493A (en) | 1939-12-12 |
Family
ID=22033658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US61113A Expired - Lifetime US2183493A (en) | 1936-01-27 | 1936-01-27 | Germicidal and antiseptic composition |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US2183493A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2507299A (en) * | 1946-05-09 | 1950-05-09 | Prophy Lac Tic Brush Company | Nylon article rendered self-sterilizing by treatment with an aryl mercuric compound and method of making it |
| US2552388A (en) * | 1947-04-22 | 1951-05-08 | American Res Associates Inc | Method of killing weeds |
| US2836516A (en) * | 1955-05-02 | 1958-05-27 | Weco Products Company | Method of treating nylon bristles and products produced thereby |
| US2853449A (en) * | 1955-09-02 | 1958-09-23 | Moudry Zdenek Vaclav | Slime preventative compositions and methods |
| US20030157521A1 (en) * | 1999-04-12 | 2003-08-21 | Afar Daniel E. | Novel 13-transmembrane protein expressed in prostate cancer |
| US20040029795A1 (en) * | 2000-04-12 | 2004-02-12 | Raitano Arthur B. | Nucleic acid and corresponding protein entitled 24P4C12 useful in treatment and detection of cancer |
-
1936
- 1936-01-27 US US61113A patent/US2183493A/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2507299A (en) * | 1946-05-09 | 1950-05-09 | Prophy Lac Tic Brush Company | Nylon article rendered self-sterilizing by treatment with an aryl mercuric compound and method of making it |
| US2552388A (en) * | 1947-04-22 | 1951-05-08 | American Res Associates Inc | Method of killing weeds |
| US2836516A (en) * | 1955-05-02 | 1958-05-27 | Weco Products Company | Method of treating nylon bristles and products produced thereby |
| DE1051794B (en) * | 1955-05-02 | 1959-03-05 | Weco Products Company | Use of phenyl mercury compounds to impregnate super polyamide bristles |
| DE1051794C2 (en) * | 1955-05-02 | 1959-09-24 | Weco Products Company | Use of phenyl mercury compounds to impregnate super polyamide bristles |
| US2853449A (en) * | 1955-09-02 | 1958-09-23 | Moudry Zdenek Vaclav | Slime preventative compositions and methods |
| US20030157521A1 (en) * | 1999-04-12 | 2003-08-21 | Afar Daniel E. | Novel 13-transmembrane protein expressed in prostate cancer |
| US20040029795A1 (en) * | 2000-04-12 | 2004-02-12 | Raitano Arthur B. | Nucleic acid and corresponding protein entitled 24P4C12 useful in treatment and detection of cancer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US2496270A (en) | Skin dressings with fugitive colors | |
| US2250480A (en) | Dihydroxy hexachloro diphenyl methane and method of producing the same | |
| US2183493A (en) | Germicidal and antiseptic composition | |
| US2361624A (en) | Stabilized therapeutic agents | |
| US2465470A (en) | Insect repellent stick | |
| US2609383A (en) | Nitrobenzyl thiophosphate esters | |
| GB283223A (en) | Manufacture of photographic silver salt emulsions | |
| US2647928A (en) | Stabilized compositions of hydroxyphenylammonium halides | |
| US2255916A (en) | Ethers of glycerol | |
| US2033921A (en) | Solution of ergot alkaloids | |
| US2220981A (en) | Fungicide | |
| US2273443A (en) | Organic mercury compound | |
| US2478191A (en) | Reaction products of p-aminobenzenesulfonamides and vasoconstrictor amines | |
| US2104738A (en) | Bismuth allantoinate and process of making it | |
| US2134463A (en) | Inhalant | |
| US2380716A (en) | Water soluble compounds having vitamin k activity | |
| US1688964A (en) | Hans hahl | |
| US2352287A (en) | Aminophenol derivatives | |
| US1744061A (en) | Shaving preparation | |
| US2065110A (en) | Method of preparing metal picrates | |
| US1128637A (en) | Hydrogen-peroxid solution. | |
| US2318388A (en) | Hexyl-dichloro resorcinol antiseptic | |
| US2214278A (en) | Basic methyl mercury nitrate | |
| US1820761A (en) | Mercuric ricinoleate | |
| US2637741A (en) | Dibenzyl tetrathiodiglycolate |