US20240115505A1 - Device and method for forming spherical particle clusters with ultrafine powders - Google Patents

Device and method for forming spherical particle clusters with ultrafine powders Download PDF

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US20240115505A1
US20240115505A1 US18/201,116 US202318201116A US2024115505A1 US 20240115505 A1 US20240115505 A1 US 20240115505A1 US 202318201116 A US202318201116 A US 202318201116A US 2024115505 A1 US2024115505 A1 US 2024115505A1
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Prior art keywords
clusters
fine powder
spherical particle
particle clusters
screens
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Inventor
Hang Zhou
Yingliang Ma
Jianhui Liu
Jingxu Zhu
Kaiqi Shi
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Suzhou Inhal Pharma Co Ltd
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Suzhou Inhal Pharma Co Ltd
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Assigned to Suzhou Inhal Pharma Co., Ltd. reassignment Suzhou Inhal Pharma Co., Ltd. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LIU, JIANHUI, MA, YINGLIANG, SHI, KAIQI, ZHOU, HANG, ZHU, JINGXU
Publication of US20240115505A1 publication Critical patent/US20240115505A1/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/14—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in rotating dishes or pans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/006—Coating of the granules without description of the process or the device by which the granules are obtained
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/10—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in stationary drums or troughs, provided with kneading or mixing appliances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/22—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
    • B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
    • B07B1/28—Moving screens not otherwise provided for, e.g. swinging, reciprocating, rocking, tilting or wobbling screens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
    • B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
    • B07B1/46—Constructional details of screens in general; Cleaning or heating of screens

Definitions

  • the present disclosure belongs to the technical field of pharmaceutical devices, and in particular relates to a device suitable for forming spherical particle clusters from fine powder, and a use method thereof.
  • Fine particles often exhibit poor flowability, and have high surface free energy, particularly particles having a particle size of less than 20 ⁇ m. Due to the influence of the van der Waals force between the particles, these particles are usually easy to agglomerate together, and these agglomerates have a low bulk density and have poor flowability, which is often not conducive to transporting and metering. In certain fields, such as inhalation preparations, it is often desirable for powder to have a small particle size but good flowability and dispersibility.
  • a dispersing agent such as lactose
  • a third component such as mannitol, phospholipid, leucine, magnesium stearate, polyethylene glycol 6000 and the like into formulae of these inhalation preparations to improve the flowability.
  • the fine particles When the fine particles are shaken, it can be found that the fine particles agglomerate with each other into clusters of particles, and these clusters of particles may be irregular, but tend to form spherical shapes. In general, the flowability of these clusters of particles is significantly better than that in a powder state, but these clusters of particles have very low strength, and are easy to break and disperse.
  • the fine powder By using the phenomenon that the fine particles agglomerate with each other into clusters of particles by shaking or vibrating, the fine powder can be prepared into clusters of particles by applying a certain form of shaking or vibrating to fine powder, and by adjusting the time and intensity of the shaking or vibrating, spherical clusters of particles with a controlled roundness, intensity and particle size can be obtained.
  • Kazuhiko Ikegami et al (Journal of Controlled Release Volume 88, Issue 1, 23-33 (2003)) prepared agglomerates of KSR-592 ⁇ -type acicular crystals by using a liquid spherical agglomeration method, and the particle size and mechanical strength of the agglomerates are controlled by changing the stirring speed of an agglomeration system.
  • the prepared agglomerates exhibit ideal flowability, and are effectively decomposed into fine inhalable particles in a grinding chamber of a device (Jethaler).
  • WO9509615 describes a method in which micronized drugs are extruded by a screw extruder to form agglomerates, and these agglomerates are spheroidized to obtain free flowing and crushable pellets.
  • U.S. Pat. No. 5,143,126A describes a device which vibrates a poorly flowing powder through a helical mechanical vibrator to form flowable agglomerates of particles which can be further transported and quantified.
  • the present disclosure provides a device suitable for forming spherical particle clusters from fine powder and a use method thereof, and the device is a device through which spherical particle clusters having a controlled particle size and a controlled hardness can be prepared from the fine powder by using a rolling granulation principle without adding any solution or solid binder.
  • the device includes the following components: a) a preforming device for preforming particle clusters formed from fine powder, so that the particle clusters have a certain strength and shape while conveying the particle clusters to a next device at a certain speed; b) a spheroidizing device for further strengthening the particle clusters formed by a) the preforming device, so that the particle clusters have a higher sphericity and hardness; and c) a grading device for sieving the particle clusters spheroidized by b) the spheroidizing device to obtain particle clusters of different particle size ranges.
  • the present disclosure adopts the technical solutions as follows.
  • a device suitable for forming spherical particle clusters from fine powder includes a preforming device, a spheroidizing device and a grading device, wherein
  • the preforming device includes one or more screens and a vibration groove, wherein the vibration groove is disposed under the screens;
  • rotating metal disc is used to spheroidize the powder and form particles.
  • an initial raw material is fed into the device by a feeding device for treatment; wherein the feeding device may be a screw feeder, a vibration feeder or other forms of feeders, preferably the screw feeder, more preferably a twin screw feeder; and the feeder performs feeding through a hopper provided with a rotating stirring knife inside for forcing a poorly flowing material to flow, avoiding powder bridging.
  • the feeding device may be a screw feeder, a vibration feeder or other forms of feeders, preferably the screw feeder, more preferably a twin screw feeder; and the feeder performs feeding through a hopper provided with a rotating stirring knife inside for forcing a poorly flowing material to flow, avoiding powder bridging.
  • the screens have a pore size of 100-2000 ⁇ m;
  • one or more rotating scrapers with adjustable directions and speeds are arranged on the screens, and the scrapers are used for forcing fine powder clusters that do not pass through the screens to pass through the screens;
  • the vibration groove is a U-shaped groove, a V-shaped groove or any other shaped groove structure.
  • the vibration groove is a U-shaped groove.
  • one or more vibration units having an adjustable vibration frequency and intensity are arranged under the vibration groove, and the vibration units are used for vibrating the vibration groove and making fluffy clusters passing through the screens to have a certain hardness and preliminarily shaped.
  • an angle between the vibration groove and a horizontal plane is 0-30°.
  • a lifting lever is disposed between the vibration groove and the horizontal plane.
  • the present disclosure further discloses a method of a device suitable for forming spherical particle clusters from fine powder, including the following steps of:
  • the prepared spherical particle clusters have good flowability, are easy to transport and quantify, and can be redispersed into fine powder under the action of an airflow.
  • the particle size of the fine powder in the step a) is less than 20 ⁇ m; preferably less than 10 ⁇ m, more preferably less than 5 ⁇ m.
  • the fluffy clusters are prepared by scraping the fine powder to pass through screens by scrapers, wherein the screens have a pore size of 100-2000 ⁇ m, preferably 200-1000 ⁇ m.
  • a device for vibrating in the step b) is a vibration groove, wherein a vibration frequency of the vibration groove is 10-300 HZ, wherein an angle between the vibration groove and a horizontal plane is 0-30°.
  • the vibration groove can select a U-shaped groove.
  • a device for spheroidizing in the step c) is a rotatable metal disc, wherein a rotation speed of the metal disc is 5-90 RPM, preferably 20-60 RPM, wherein an angle between a bottom surface of the metal disc and the horizontal plane is 0-80°, preferably 20-50°.
  • the prepared spherical particle clusters are graded by using one or more screens of different pore sizes;
  • the spherical particle clusters prepared in the step d) have a hardness of less than 50 mN.
  • the present disclosure provides the device suitable for forming the spherical particle clusters from the fine powder, which is a device through which spherical particle clusters having a controlled particle size and a controlled hardness can be prepared from the fine powder by using the rolling granulation principle without adding any solution or solid binder.
  • the present disclosure also provides a method for forming spherical particle clusters from fine powder, and the prepared spherical particle clusters are good in flowability, are easy to transport and quantify, and can be redispersed into fine powder under the action of an airflow, and the method includes the steps of: a) preparing fine powder having a particle size of less than 20 ⁇ m into fluffy clusters; b) vibrating the fluffy clusters to increase their hardness and make the fluffy clusters preliminarily shaped; c) spheroidizing the preliminarily shaped clusters with an increased hardness to prepare spherical particle clusters with a higher roundness and a greater hardness; and d) grading the spherical particle clusters to remove fine powder and spherical particle clusters with an excessive particle size.
  • FIG. 1 is a partial device diagram of a first embodiment of the present disclosure
  • FIG. 2 is a partial device diagram of a second embodiment of the present disclosure
  • FIG. 3 is a first graph of the change in morphology of spherical particle clusters formed from fine powder in different stages according to the present disclosure
  • FIG. 4 is a second graph of the change in morphology of spherical particle clusters formed from fine powder in different stages according to the present disclosure
  • FIG. 5 is a third graph of the change in morphology of spherical particle clusters formed from fine powder in different stages according to the present disclosure
  • FIG. 6 is a fourth graph of the change in morphology of spherical particle clusters formed from fine powder in different stages according to the present disclosure
  • FIG. 7 is a fifth graph of the change in morphology of spherical particle clusters formed from fine powder in different stages according to the present disclosure.
  • FIG. 8 is a diagram of large particle clusters prepared without a preforming device according to the present disclosure.
  • cluster refers to an aggregate of fine particles.
  • bulk density refers to a mass per unit volume measured immediately after free filling of powder or particles in a certain container.
  • roundness is used to evaluate whether particles are close to be circular, the closer the value is to 1, the higher the roundness, and a roundness calculation formula is as follows:
  • Area is an area of a projection of particles in an instrument
  • Spindle length is a length of a major axis of the projection.
  • particle size distribution refers to the percentage of particles of different particle sizes in the total number of particles in a powder sample reflected by using particular instruments and methods.
  • D90 means the corresponding particle size when the cumulative particle size distribution of a sample reaches 90%, and its physical meaning is that 90% of the particles have a particle size of smaller (or larger) than D90.
  • high shear mixer refers to an agitator with paddles and blades that can rotate at a high speed.
  • the device for forming the spherical particle clusters from the fine powder of the present disclosure is as shown in FIGS. 1 and 2 .
  • the device includes: a) a preforming device, b) a spheroidizing device, and c) a grading device.
  • the preforming device includes a first screen 1 of a specific pore size, one or more rotating scrapers 2 are arranged on the first screen 1 , a hopper 3 is connected to a position under the first screen 1 , and a U-shaped vibration groove 4 is connected to a vibration unit 5 which is controlled to vibrate by a vibration controller 6 .
  • Fine powder tends to agglomerate into clusters much larger than single particles due to their large acting force between particles, and when the clusters fall onto the first screen 1 through a feeder, the rotating scrapers 2 press the clusters to pass through the screen, thus obtaining clusters of a certain size, wherein the size of the clusters is mainly determined by apore size of the first screen 1 , and the pore size of the first screen 1 is 100-2000 ⁇ m, preferably 200-1000 ⁇ m, more preferably 300-600 ⁇ m. At this time, the clusters are also irregular and very fluffy, and further treatment is required to improve their roundness and strength.
  • the clusters passing through the first screen 1 fall onto the U-shaped vibration groove 4 in a concentrated manner through the hopper 3 .
  • the vibration groove 4 is made of metal.
  • the vibration controller 6 controls the vibration unit 5 to drive the U-shaped vibration groove 4 to vibrate.
  • the vibration unit 5 includes, but is not limited to, one or more of ultrasonic vibration, percussive vibration, and acoustical vibration. In this embodiment, an ultrasonic vibrator is selected.
  • the U-shaped vibration groove 4 continuously beats the clusters, making the originally fluffy clusters more compact, and making the clusters move forward continuously.
  • a base 7 is adjustable in angle, and by adjusting the angle of the base 7 , the inclination angle of the U-shaped vibration groove 4 can be changed, wherein the angle is 0-30°, preferably 0-15°.
  • the clusters passing through a) the preforming device are more compact and have better flowability, and the clusters enter b) the spheroidizing device for further spheroidizing to obtain a desired roundness and hardness.
  • the spheroidizing device includes a rotating metal disk 8 , the rotating metal disk 8 is provided with a plurality of baffles 9 , the rotating metal disk 8 is fixed on a rotating shaft 10 , a motor 11 controls the rotating shaft 10 to rotate and drives the rotating metal disk 8 to rotate, and a spheroidizing device controller 12 can control a rotation speed and an elevation angle of the rotating shaft 10 .
  • the preformed clusters fall into the rotating metal spheroidizing disk 8 , the clusters are continuously rolled in the rotating metal disk 8 , and the baffles 9 allow the clusters to roll more vigorously, which promotes faster formation of the clusters and increases the hardness of the clusters.
  • the rotation speed and the elevation angle of the rotating shaft 10 By adjusting the rotation speed and the elevation angle of the rotating shaft 10 , different rolling states can be obtained. The faster the rotation speed and the greater the elevation angle, the more vigorous the rolling of the clusters. However, too fast a rotation speed will cause the clusters to be subjected to a large centrifugal force, causing the clusters to stay at the edge of the wall of the rotating metal disk.
  • the rotation speed is controlled to be 5-90 RPM/min, preferably 20-60 RPM/min in the present disclosure.
  • Too small an elevation angle will cause the clusters to not roll, while too large an elevation angle will cause the clusters to accumulate all the way on the bottom of the rotating metal disk 8 . Both the too small elevation angle and the too large elevation angle do not contribute to the rolling of the clusters.
  • the angle between the rotating metal disk 8 and a horizontal plane is 0-80°, preferably 10-60°, more preferably 30-50° in the present disclosure.
  • the rolling time increases, the shapes of the clusters become more and more spherical, and their hardness gradually increases, and the rolling time is 1-60 min, preferably 5-45 min, more preferably 10-30 min
  • the clusters have good flowability and a certain hardness, but the particle clusters are usually of different sizes, and c) the grading device can grade the particle clusters according to different particle sizes to obtain spherical particle clusters of different sizes.
  • the grading device includes one or more second screens 13 , which are stacked with each other according to pore sizes, the larger the pore size of a screen, the higher the position where the screen is located, and a collection tray 14 for collecting finest particles is located at the lowermost part.
  • the second screens 13 and the collection tray 14 are stacked with each other and fixed to a shaker 15 , and the shaking amplitude and time are controlled by a controller 16 .
  • Particle clusters spheroidized by b) the spheroidizing device fall to the uppermost screen, and by rocking vibration, the particle clusters fall gradually until the particle clusters cannot pass through the screen, the particle clusters of different particle sizes are trapped on the screens of different pore sizes, respectively.
  • this embodiment makes a change to the shape of the vibration groove
  • a) the preforming device includes a first screen 1 of a specific pore size, one or more rotating scrapers 2 are arranged on the first screen 1 , a hopper 3 is connected to a position under the first screen 1 , and a V-shaped vibration groove is connected to a vibration unit 5 which is controlled to vibrate by a vibration controller 6 .
  • the angle of a base 7 By adjusting the angle of a base 7 , the inclination angle of the V-shaped vibration groove can be changed, wherein the angle is 0-30°, preferably 0-15°.
  • the particle clusters were treated by b) the spheroidizing device and c) the grading device as in the first embodiment of the present disclosure.
  • lactose was used as an experimental material, lactose having a D90 of about 10 ⁇ m, and lactose powder was treated by the device of the present disclosure, with a spheroidizing time of 10 min, and its morphology and roundness changes in various stages were measured, as shown in Table 1.
  • lactose having a D90 of about 10 ⁇ m and arginine having a D90 of less than 5 ⁇ m were used as experimental materials, the two were mixed in a mass ratio of 4:1 (lactose: arginine) by using a high shear mixer, and then mixed powder was treated by the device of the present disclosure, with a spheroidizing time of 10 min, and its content, hardness, roundness, bulk density and yield were measured, as shown in Table 2.
  • lactose with a D90 of about 10 ⁇ m was used as an experimental material, and lactose powder was treated by the device of the present disclosure, wherein the spheroidizing time of a spheroidizing device was set to be 0 min, 5 min, 10 min, 20 min, and 30 min, respectively, and the hardness and roundness of the final spheroidized clusters were measured, as shown in Table 3.
  • Increasing the spheroidizing time can significantly improve the hardness and roundness of the final spheroidized clusters.
  • the properties of spheroidized clusters produced by spheroidizing of a material after passing through the preforming device were compared with those of spheroidized clusters produced by granulating without the preforming device.
  • clusters produced without the preforming device have a significantly larger particle size, the proportion of large clusters is high, and the sphericity of the large clusters is low (as shown in FIG. 8 ). This is due to the fact that clusters that are not preformed by the preforming device are relatively fluffy and irregular. If the clusters are spheroidized directly in a spheroidizing disk of a spheroidizing device, the fluffy clusters will squeeze against each other and adhere with each other to form larger clusters. These large clusters, due to their larger mass, continue to squeeze and adhere smaller clusters during spheroidizing.
  • Lactose with a D90 of about 10 ⁇ m was spheroidized by using the device of the present disclosure, screens of 100 ⁇ m, 300 ⁇ m and 500 ⁇ m were used respectively, the spheroidizing time of a spheroidizing device was set to be 10 min, and spherical clusters were graded by using a combination of screens of 100 ⁇ m, 200 ⁇ m, 300 ⁇ m, 400 ⁇ m, 500 ⁇ m, and 600 ⁇ m after the end of spheroidizing, and the proportion of particles at all levels was calculated, as shown in Table 5.
  • the pore size of the screens has a significant effect on the particle size distribution of the spheroidized clusters, the larger the pore size, the larger the particle size of the resulting clusters.
  • the present disclosure provides the device suitable for forming the spherical particle clusters from the fine powder, through which spherical particle clusters having a controlled particle size and a controlled hardness can be prepared from the fine powder by using the rolling granulation principle without adding any solution or solid binder.
  • the present disclosure also provides a method for forming spherical particle clusters from fine powder, and the prepared spherical particle clusters are good in flowability, are easy to transport and quantify, and can be redispersed into fine powder under the action of an airflow, and the method includes the steps of: a) preparing fine powder having a particle size of less than 20 ⁇ m into fluffy clusters; b) vibrating the fluffy clusters to increase their hardness and make the fluffy clusters preliminarily shaped; c) spheroidizing the preliminarily shaped clusters with an increased hardness to prepare spherical particle clusters with a higher roundness and a greater hardness; and d) grading the spherical particle clusters to remove fine powder and spherical particle clusters with an excessive particle size.

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CN202210565160.5A CN114917831B (zh) 2022-05-23 2022-05-23 一种适用于微细粉末形成球形颗粒簇团的装置及使用方法
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DE59100388D1 (de) * 1990-01-29 1993-10-28 Ciba Geigy Verfahren und Vorrichtung zur Dosierung eines feinkörnigen Pulvers.
JP3373098B2 (ja) * 1995-11-09 2003-02-04 濱田重工株式会社 振動式造粒装置及び方法
JP2020037502A (ja) * 2018-09-05 2020-03-12 日本軽金属株式会社 アルミナ粒子の製造方法
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CN212550368U (zh) * 2020-05-08 2021-02-19 张晶晶 一种西药制药用颗粒筛选装置
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