US20220160641A1

US20220160641A1 - Capsule with internal diaphragm for improved bioavailability

Info

Publication number: US20220160641A1
Application number: US17/488,787
Authority: US
Inventors: Tobias Johan Louw
Original assignee: Combocap Inc
Current assignee: Combocap Inc
Priority date: 2015-10-09
Filing date: 2021-09-29
Publication date: 2022-05-26
Also published as: US11160759B1; US20180289625A1; CN108366970A; EP3359131A4; US20180296489A1; US11357732B2; EP3359130A1; WO2017062951A1; CN108472244A; EP3359130A4; CN108366959A; US11478429B2; WO2017062954A1; EP3359140A1; EP3359131A1; EP3359140A4; WO2017062956A1

Abstract

A multi-compartment capsule may include a body, a diaphragm between, which seals off the body and provides a first compartment to hold an ingredient, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding an oil. A two-compartment capsule may include a body, a diaphragm between, which seals off the body and provides a first compartment to hold an oil, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding an ingredient. The ingredient may have increased bioavailability after exposure to the oil. This disclosure also provides particular formulations for use in such a capsule.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No. 15/767,010, filed Apr. 9, 2018, entitled “Capsule with International Diaphragm for Improved Bioavailability,” which is a U.S. national stage filing under 35 U.S.C. § 371 of International Application No. PCT/US2016/056285 filed Oct. 10, 2016 entitled “Capsule with Internal Diaphragm for Improved Bioavailability,” which claims priority to and benefit of U.S. Provisional Application No. 62/239,435 filed Oct. 9, 2015, entitled “Capsule with Volume-Adjustable Internal Diaphragm,” U.S. Provisional Application No. 62/239,454 filed Oct. 9, 2015, entitled “Capsule with Internal Diaphragm for Improved Bioavailability,” and U.S. Provisional Application No. 62/239,442 filed Oct. 9, 2015, entitled “Capsule with Internal Diaphragm and Solid Ingredients.” The contents of each of these applications are hereby incorporated herein by reference in their entireties.

SUMMARY

Embodiments described herein are directed to a multi-compartment capsule comprising a body; a diaphragm, having two sidewalls and a bottom, extending into the body and defining a first compartment between an outer surface of the diaphragm and an inner surface of the body, adapted to hold an oil; and a cap mounted to an outer surface of the body and opposed to the diaphragm, and defining a second compartment between an inner surface of the diaphragm and the cap, adapted to hold an ingredient which has increased bioavailability after exposure to the oil; wherein the two sidewalls of the diaphragm extend along the inner surface of the body and are aligned with an open end of the body. In some embodiments, the capsule is a size 00 capsule. In some embodiments, the first compartment is hermetically sealed by the diaphragm.
In some embodiments, the oil is selected from the group consisting of omega-3 oil, red palm oil, fish oil, krill oil, walnut oil, saw palmetto oil, castor oil, garlic oil, flaxseed oil, canola oil, soybean oil, cannabis oil, argan oil, coconut oil, peppermint oil, evening primrose oil, oregano oil, emu oil, cod liver oil, algae oil, grape seed oil, rose oil, clove oil, vitamin E oil, blueberry seed oil, raspberry seed oil, pumpkin seed oil, hemp oil, alpha-linolenic acid, and combinations thereof.
In some embodiments, the omega-3 oil is selected from the group consisting of alpha-linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, krill oil, fish oil, walnut oil, flaxseed oil, canola oil, soybean oil, and combinations thereof.
In some embodiments, the ingredient is an oil, a liquid, a powder, a granule, a semi-solid, a gel, a beadlet, a microbead, a liquid, or a combination thereof.
In some embodiments, the ingredient is an oil, a probiotic, a botanical, an herbal extract, a digestive enzyme, a vitamin, a carotenoid, a collagen, a medicament, or a combination thereof.
In some embodiments, the bottom of the diaphragm may be flattened. In some embodiments, the bottom of the diaphragm may be curved. In some embodiments, the bottom of the diaphragm may be substantially or partially flattened.
In some embodiments, the oil comprises an omega-3 oil and the ingredient is a multivitamin powder, or a multivitamin powder and coenzyme Q10.
In some embodiments, the oil comprises an omega-3 oil and the ingredient is a statin, or a statin and coenzyme Q10.
In some embodiments, the oil comprises an omega-3 oil and the ingredient is vitamin K2.
In some embodiments, the oil comprises alpha-linolenic acid and the ingredient is selected from chromium, or chromium and coenzyme Q10.
In some embodiments, the oil is saw palmetto oil and the ingredient is a liothyronine sodium (T3) powder.
In some embodiments, the oil is red palm oil, and the ingredient is selected from vitamin D, vitamin K2, a multivitamin or a combination thereof.
In some embodiments, the oil is an omega-3 oil, and the ingredient is selected from aspirin, a statin, or a combination thereof.
Some embodiments described herein are directed to a multi-compartment capsule comprising a body; a diaphragm, having two sidewalls and a bottom, extending into the body and defining a first compartment between an outer surface of the diaphragm and an inner surface of the body, adapted to hold an ingredient; and a cap mounted to an outer surface of the body and opposed to the diaphragm, and defining a second compartment between an inner surface of the diaphragm and the cap, adapted to hold an oil; wherein the two sidewalls of the diaphragm extend along the inner surface of the body and are aligned with an open end of the body.
In some embodiments, the second compartment is sealed to prevent oil leakage.
In some embodiments, the ingredient has increased bioavailability upon exposure to the oil.

DESCRIPTION OF THE FIGURES

FIG. 1 illustrates a cross-sectional view of a capsule of embodiments herein wherein the first (lower) compartment has a volume of about 423 mm³and the second (upper) compartment has a volume of about 497 mm³, and wherein the first compartment comprises an oil and the second compartment comprises an ingredient.

FIG. 2 illustrates a cross-sectional view of a capsule of embodiments herein wherein the first (lower) compartment has a volume of 743 mm³and the second (upper) compartment has a volume of 176 mm³, and wherein the first compartment comprises an oil and the second compartment comprises an ingredient.

FIG. 3 illustrates a cross-sectional view of a capsule of embodiments herein with a flattened bottom, wherein each compartment comprises a solid ingredient.

FIGS. 4A, 4B, and 4C illustrate standard and elongated TORPAC capsule sizes, which may be used in some embodiments described herein.

DETAILED DESCRIPTION

Before the present compositions and methods are described, it is to be understood that this invention is not limited to the particular processes, compositions, or methodologies described, as these may vary. It is also to be understood that the terminology used in the description is for the purpose of describing the particular versions or embodiments only, and is not intended to limit the scope of the present invention, which will be limited only by the appended claims. Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of embodiments of the present invention, the preferred methods, devices, and materials are now described. All publications mentioned herein are incorporated by reference in their entireties. Nothing herein is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention.
It must also be noted that as used herein and in the appended claims, the singular forms “a,” “an,” and “the” include plural references unless the context clearly dictates otherwise. Thus, for example, reference to “an ingredient” is a reference to one or more ingredients and equivalents thereof known to those skilled in the art, and so forth.
As used herein, the term “about” means plus or minus 10% of the numerical value of the number with which it is being used. Therefore, about 50 mg means in the range of 45 mg-55 mg.
The term “patient” or “subject” as used herein is an animal, particularly a human, suffering from an unwanted disease or condition that may be treated by the therapeutics and/or compositions described herein.
“Optional” or “optionally” means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Throughout the specification of the application, various terms are used such as “primary,” “secondary,” “first,” “second,” and the like. These terms are words of convenience used to distinguish between different elements, and such terms are not intended to limit how the different elements may be used.
As used herein, the term “medicament” or “therapeutic” means an agent used to treat, combat, ameliorate, prevent or improve an unwanted condition or disease of a subject.
A “therapeutically effective amount” or “effective amount” of a composition is an amount necessary or sufficient to achieve the desired result. The activity contemplated by the embodiments herein includes medically therapeutic, cosmetically therapeutic and/or prophylactic treatment, as appropriate. A therapeutically effective amount of the compound of embodiments herein is typically an amount such that when it is administered in a physiologically tolerable excipient composition, it is sufficient to achieve an effective systemic concentration or local concentration in or on the tissue to achieve the desired therapeutic or clinical outcome.
The terms “treat,” “treated,” or “treating,” as used herein, refer to therapeutic treatment, cosmetic treatment, and/or prophylactic or preventative measures, wherein the object is to prevent or slow down (lessen) an undesired physiological condition, disorder, or disease, or to obtain beneficial or desired clinical results. For the purposes of this invention, beneficial or desired clinical results include, but are not limited to, alleviation of symptoms; diminishment of the extent of the condition, disorder, or disease; stabilization (i.e., not worsening) of the state of the condition, disorder, or disease; delay in onset or slowing of the progression of the condition, disorder, or disease; amelioration of the condition, disorder, or disease state; and remission (whether partial or total), whether detectable or undetectable, or enhancement or improvement of the condition, disorder, or disease. Treatment includes eliciting a clinically significant response without excessive levels of side effects.
As used herein, the term “consists of” or “consisting of” means that the formulation includes only the elements, steps, or ingredients specifically recited in the particular claimed embodiment or claim.
As used herein, the term “consisting essentially of” or “consists essentially of” means that the only active pharmaceutical ingredient in the formulation or method that treats the specified condition is the specifically recited therapeutic in the particular embodiment or claim.
Capsules are typically manufactured in certain standard sizes, such as TORPAC sizes, referred to as a capsule size designated by numerals, such as 000, 00, etc. Such capsules typically have two parts: a cap and a body, which are bonded or fitted together. One of the most common sizes is the 00 capsule. The typical size 00 capsule, in common with other capsules, has a standardized nominal volume. For instance, a size 00 capsule has a volume of approximately 0.95 milliliters. In some embodiments described below, the multi-compartment capsule is a size 00 capsule. In some embodiments, the capsule size may be size 000, size 0, size 1, size 2, size 3, size 4, or size 5, or any non-standard size in between these sizes. In some embodiments described below, the capsule size may be elongated (“EL”), such that the size may be, for example, 00 EL. In some embodiments, the elongation may be to any standard length or to a non-standard length. In some embodiments, the elongated capsule may add from about 50 mm³to about 150 mm³of additional volume to the first compartment, the second compartment, or a combination thereof. In some embodiments, the elongated capsule may add about 110 mm³of additional volume to the first compartment, the second compartment, or a combination thereof. In some embodiments, if the diaphragm's diameter is reduced, it may be possible to insert a longer diaphragm into the capsule, thereby changing the available volumes in both the first and second compartments. In some embodiments, scaling the dimensions of the multi-compartment capsule described herein may result in a larger or smaller capsule with substantially the same ratios as described herein. In some embodiments, scaling the dimensions of the multi-compartment capsule described herein may result in a larger or smaller capsule with ratios different from those described herein.
Exemplary benefits of such two-compartment capsules may include increased patient compliance, a double-chamber controlled release, increased efficacy or bioavailability of ingredients due to co-administration, increased stability, and the ability to formulate difficult combinations of ingredients into one capsule, such as incompatible actives which can now be co-administered.
For some applications, it may be advantageous to deliver one or more ingredients in the form of a capsule with two compartments. For some applications, it may advantageous for the one or more ingredients delivered in such a capsule to be ingredients which have improved bioavailability when dissolved in one or more oils.
Embodiments described herein are directed to a multi-compartment capsule comprising a body; a diaphragm, having two sidewalls and a bottom, extending into the body and defining a first compartment between an outer surface of the diaphragm and an inner surface of the body; and a cap mounted to an outer surface of the body and opposed to the diaphragm, and defining a second compartment between an inner surface of the diaphragm and the cap; wherein the two sidewalls of the diaphragm extend along the inner surface of the body and are aligned with an open end of the body. In some embodiments, the capsule is a size 00 capsule.
In some embodiments, the multi-compartment capsule may comprise a body; a diaphragm, having two sidewalls and a bottom, extending into the body and forming a first compartment defined by a first surface of the diaphragm and the body; and a cap mounted to the body and opposed to the diaphragm, the cap forming a second compartment defined by an opposing surface of the diaphragm and the cap; wherein the two sidewalls of the diaphragm extend along the inner surface of the body and are aligned with an open end of the body; and wherein the first compartment and the second compartment are each adapted to hold one or more solid ingredients. In some embodiments, the first compartment is hermetically sealed by the diaphragm. In some embodiments, the one or more solid ingredients comprises an oil, a liquid, a powder, a granule, a semi-solid, a microbead, a beadlet, or a combination thereof.
In some embodiments, the bottom of the diaphragm may be flattened. A flatter bottom may allow for more volume in the lower compartment. In some embodiments, the bottom of the diaphragm may be curved. In some embodiments, the bottom of the diaphragm may be substantially or partially flattened.
In some embodiments, the contents of the first compartment and the contents of the second compartment may be released simultaneously. This simultaneous release may occur because each end of the multi-compartment capsule comprises the same or substantially the same material composition and thickness, such that when the capsule is digested, both compartments are degraded simultaneously. This simultaneous release may be advantageous in some embodiments wherein the contents of the first compartment and the contents of the second compartment may provide improved bioavailability or other synergistic effects when combined by such a release.
In some embodiments, the first compartment comprises an oil. In some embodiments, the second compartment comprises an ingredient. In some embodiments, the second ingredient is adapted to hold an ingredient which has increased bioavailability after exposure to the oil. In some embodiments, the first compartment comprises an ingredient having increased bioavailability after exposure to oil and the second compartment comprises an oil. Exemplary formulations described below could be used with oil in either compartment.
In some embodiments, the two sidewalls of the diaphragm extend along the inner surface of the body and are aligned with an open end of the body. In some embodiments, the capsule is a size 00 capsule. In some embodiments, the first compartment is hermetically sealed by the insertion and sealing of the diaphragm into the capsule body.
In some embodiments, the bottom of the diaphragm may be flattened. In some embodiments, the bottom of the diaphragm may be curved. In some embodiments, the bottom of the diaphragm may be substantially or partially flattened.
In some embodiments, the oil is selected from the group consisting of omega-3 oil, red palm oil, fish oil, krill oil, walnut oil, saw palmetto oil, castor oil, garlic oil, flaxseed oil, canola oil, soybean oil, cannabis oil, argan oil, coconut oil, peppermint oil, evening primrose oil, oregano oil, emu oil, cod liver oil, algae oil, grape seed oil, rose oil, clove oil, vitamin E oil, blueberry seed oil, raspberry seed oil, pumpkin seed oil, hemp oil, alpha-linolenic acid, conjugated linoleic acid, docosahexaenoic acid, ginger oil, lavender oil, and combinations thereof.
In some embodiments, the omega-3 oil is selected from the group consisting of alpha-linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, krill oil, fish oil, walnut oil, flaxseed oil, canola oil, soybean oil, and combinations thereof. The omega-3 oil may be in an amount of about 10 mg to about 2000 mg.
In some embodiments, the oil may comprise a form or derivative of vitamin E In some embodiments, the oil may comprise from about 10 mg to about 500 mg of a form or derivative of vitamin E In some embodiments, the form or derivative of vitamin E may be a tocotrienol, such as, for example, alpha tocotrienol, beta tocotrienol, gamma tocotrienol, delta tocotrienol, or any combination thereof.
In some embodiments, the ingredient is an oil, a liquid, a powder, a granule, a semi-solid, a gel, a beadlet, a microbead, a liquid, or a combination thereof. In some embodiments, the ingredient is an oil, a probiotic, a botanical, an herbal extract, a digestive enzyme, a vitamin, a carotenoid, a collagen, a medicament, or a combination thereof. In some embodiments, the ingredient may comprise alpha-carotene, beta-carotene, biotin, cadmium, caffeine, calcium, cinnamon, copper, curcumin, dexmethylphenidate, dicalcium phosphate, docosahexaenoic acid, folic acid, frankincense, glucosamine, gymnema, gymnema extract, iodine, iron, linoleic acid, lipoic acid, LOWAT, lutein, lycopene, magnesium, magnesium stearate, manganese, melatonin, molybdenum, niacin, oleic acid, palmitic, panthothenic acid, passion flower, phosphorus, a plant sterol, resvida, selenium, squalene, ginseng, tocopherols, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin K, zinc, or a combination thereof.
In some embodiments, the ingredient comprises a pharmaceutical agent. In some embodiments, the pharmaceutical agent is selected from the group consisting of aspirin, a statin, ipriflavone, cohosh, castus, coenzyme Q10 (CoQ10), gauifenesin, althea root, antimony pentasulfide, creosote, guaiacolsulfonate, ipecacuanha (syrup of ipecac), levoverbenone, potassium iodide, senega, tyloxapol, ammonium chloride, salbutamol, albuterol, levosalbutamol, levalbuterol, pirbuterol, epinephrine, ephedrine, terbutaline, salmeterol, clenbuterol, formoterol, bambuerol, indacaterol, ephrinesulfate, ticlopidine, clopidogrel, prasugrel, ticagrelor, cilostazol, vorapaxar, trifusal, dipyridamole, a tocotrienol, triiodothyronine (T3), liothyronine sodium, and combinations thereof.
In some embodiments, the ingredient comprises aspirin. In some embodiments, the aspirin comprises from about 10 mg to about 500 mg. In some embodiments, the aspirin comprises from about 81 mg to about 324 mg. In some embodiments, one of the first or second compartment comprises aspirin in an amount of about 10 mg to about 500 mg.
In some embodiments, the ingredient comprises a statin. The statin may be selected from the group consisting of atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, and combinations thereof. The statin may be in an amount of about 1 mg to about 100 mg. In some embodiments, the statin may be in an amount of about 5 mg to about 40 mg. In some embodiments, one of the first or second compartment comprises a statin in an amount of about 1 mg to about 100 mg.
In some embodiments, the first compartment comprises aspirin in an amount of about 10 mg to about 500 mg and the second compartment comprises an oil in an amount of about 10 mg to about 2000 mg. In some embodiments, the oil is an omega-3 oil.
In some embodiments, the capsule may include omega-3 oil with or without red palm oil in the first compartment, and CoQ10 in the second compartment. The omega-3 oil may be in an amount of about 10 mg to about 2000 mg. The red palm oil may be in an amount of about 10 mg to about 2000 mg. The CoQ10 may be in an amount of about 10 mg to about 1000 mg.
In some embodiments, the oil comprises an omega-3 oil and the ingredient is a multivitamin, or a multivitamin and coenzyme Q10. The omega-3 oil may be in an amount of about 10 mg to about 2000 mg. The CoQ10 may be in an amount of about 10 mg to about 1000 mg. The multivitamin may be in an amount of about 1 mg to about 5000 mg.
In some embodiments, the oil comprises an omega-3 oil and the ingredient is a statin, or a statin and coenzyme Q10. The omega-3 oil may be in an amount of about 10 mg to about 2000 mg. The statin in an amount of about 1 mg to about 100 mg. The CoQ10 may be in an amount of about 10 mg to about 1000 mg.
In some embodiments, the oil comprises an omega-3 oil and the ingredient is vitamin K2. The omega-3 oil may be in an amount of about 10 mg to about 2000 mg. The vitamin K2 may be in an amount of about 10 mcg to about 1000 mcg.
In some embodiments, the oil comprises alpha-linolenic acid and the ingredient is selected from chromium, or chromium and coenzyme Q10. The alpha linolenic acid may be in an amount of about 10 mg to about 500 mg. The chromium may be in an amount of about 10 mcg to about 1000 mcg. The CoQ10 may be in an amount of about 10 mg to about 1000 mg.
In some embodiments, the oil is saw palmetto oil and the ingredient is liothyronine sodium (T3). The saw palmetto oil may be in an amount of about 10 mg to about 1000 mg. The liothyronine sodium may be in an amount of about 5 mcg to about 500 mcg.
In some embodiments, the oil is red palm oil, and the ingredient is selected from vitamin D, vitamin K2, a multivitamin or a combination thereof. The red palm oil may be in an amount of about 10 mg to about 2000 mg. The vitamin D may be in an amount of about 10 IU to about 3000 IU. The vitamin K2 may be in an amount of about 10 mcg to about 1000 mcg. The multivitamin may be in an amount of about 1 mg to about 5000 mg.
In some embodiments, the oil is red palm oil, and the ingredient is selected from lutein, lycopene, biotin, selenium, selenium (methionine), zinc, zinc (glyconate), or a combination thereof. The red palm oil may be in an amount of about 10 mg to about 2000 mg. The lutein may be in an amount of about 1 mg to about 30 mg. The lycopene may be in an amount of about 1 mg to about 30 mg. The biotin may be in an amount of about 0.01 mg to about 10 mg. The selenium or selenium (methionine) may be in an amount of about 1 mcg to about 200 mcg. The zinc or zinc (glyconate) may be in an amount of about 1 mg to about 45 mg.
In some embodiments, the oil is an omega-3 oil and the ingredient is selected from frankincense, gymnema, gymnema extract, cinnamon, chromium, chromium (picolinate), vitamin B6, vitamin B12, or a combination thereof. The omega-3 oil may be in an amount of about 10 mg to about 2000 mg. The frankincense may be in an amount of about 1 mg to about 500 mg. The gymnema or gymnema extract may be in an amount of about 10 mg to about 1000 mg. The cinnamon may be in an amount of about 10 mg to about 1000 mg. The chromium or chromium (picolinate) may be in an amount of about 10 mg to about 1000 mg. The vitamin B6 may be in an amount of about 10 mg to about 1000 mg. The vitamin B12 may be in an amount of about 10 mcg to about 1000 mcg.
In some embodiments, the oil is an omega-3 oil, and the ingredient is selected from resvida, lipoic acid, CoQ10, folic acid, vitamin B6, vitamin B12, or a combination thereof. The omega-3 oil may be in an amount of about 10 mg to about 2000 mg. The resvida may be in an amount of about 10 mg to about 1000 mg. The amount of lipoic acid may be in an amount of about 1 mg to about 1000 mg. The CoQ10 may be in an amount of about 10 mg to about 1000 mg. The folic acid may be in an amount of about 0.1 mcg to about 1000 mcg. The vitamin B6 may be in an amount of about 10 mg to about 1000 mg. The vitamin B12 may be in an amount of about 10 mcg to about 1000 mcg.
In some embodiments, the oil is selected from krill oil, red palm oil, or a combination thereof, and the ingredient is selected from oleic acid, linoleic acid, tocotrienols, tocopherols, beta-carotene, alpha-carotene, squalene, a plant sterol, CoQ10, a multivitamin, or a combination thereof. The krill oil may be in an amount of about 10 mg to about 2000 mg. The red palm oil may be in an amount of about 10 mg to about 2000 mg. The oleic acid may be in an amount of about 10 mg to about 1000 mg. The linoleic acid may be in an amount of about 1 mg to about 1000 mg. The tocotrienols may be in an amount of about 1 mg to about 1000 mg. The tocopherols may be in an amount of about 1 mg to about 1000 mg. The beta-carotene may be in an amount of about 1 mg to about 1000 mg. The alpha-carotene may be in an amount of about 1 mg to about 1000 mg. The squalene may be in an amount of about 0.1 mg to about 1000 mg. The plant sterol may be in an amount of about 1 mg to about 1000 mg. The CoQ10 may be in an amount of about 0.01 mg to about 1000 mg. The multivitamin may be in an amount of about 1 mg to about 5000 mg.
In some embodiments, the oil is selected from krill oil, an omega-3 oil such as, for example, docosahexaenoic acid (DHA), or a combination thereof, and the ingredient is selected from vitamin C, zinc, dicalcium phosphate, vitamin D, vitamin K, magnesium, calcium, or a combination thereof. The krill oil may be in an amount of about 10 mg to about 2000 mg. The DHA may be in an amount of about 10 mg to about 2000 mg. The vitamin C may be in an amount of about 1 mg to about 1000 mg. The zinc may be in an amount of about 1 mg to about 1000 mg. The dicalcium phosphate may be in an amount of about 1 mg to about 1000 mg. The vitamin D may be in an amount of about 10 IU to about 3000 IU. The vitamin K may be in an amount of about 10 mcg to about 1000 mcg. The magnesium may be in an amount of about 0.1 mg to about 1000 mg. The calcium may be in an amount of about 1 mg to about 1000 mg.
In some embodiments, the oil is krill oil, and the ingredient is selected from a multivitamin, CoQ10, vitamin A, vitamin D, vitamin D3, vitamin E, biotin, folic acid, niacin, panthothenic acid, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin K, calcium, chromium, copper, iodine, magnesium, magnesium stearate, manganese, molybdenum, phosphorus, selenium, zinc, or a combination thereof. The krill oil may be in an amount of about 10 mg to about 2000 mg. The multivitamin may be in an amount of about 1 mg to about 5000 mg. The CoQ10 may be in an amount of about 0.01 mg to about 1000 mg. The vitamin A may be in an amount of about 10 IU to about 4000 IU. The vitamin D or vitamin D3 may be in an amount of about 10 IU to about 3000 IU. The vitamin E may be in amount of about 10 IU to about 3000 IU. The biotin may be in an amount of about 10 mcg to about 1000 mcg. The folic acid may be in an amount of about 0.1 mcg to about 1000 mcg. The niacin may be in an amount of about 1 mg to about 1000 mg. The panthothenic acid may be in an amount of about 1 mg to about 1000 mg. The vitamin B1 may be in an amount of about 1 mg to about 1000 mg. The vitamin B2 may be in an amount of about 1 mg to about 1000 mg. The vitamin B2 may be in an amount of about 1 mg to about 1000 mg. The vitamin B6 may be in an amount of about 1 mg to about 1000 mg. The vitamin B12 may be in an amount of about 10 mcg to about 1000 mcg. The vitamin C may be in an amount of about 1 mg to about 1000 mg. The vitamin K may be in an amount of about 10 mcg to about 1000 mcg. The calcium may be in an amount of about 1 mg to about 1000 mg. The chromium may be in an amount of about 1 mcg to about 1000 mcg. The copper may be in an amount of about 0.1 mg to about 100 mg. The iodine may be in an amount of about 0.01 mg to about 100 mg. The magnesium may be in an amount of about 0.1 mg to about 1000 mg. The magnesium stearate may be in an amount of about 0.1 mg to about 1000 mg. The manganese may be in an amount of about 0.1 mg to about 100 mg. The molybdenum may be in an amount of about 1 mcg to about 1000 mcg. The phosphorous may be in an amount of about 1 mg to about 100 mg. The selenium may be in an amount of about 1 mcg to about 200 mcg. The zinc may be in an amount of about 1 mg to about 1000 mg.
In some embodiments, the oil is red palm oil, and the ingredient is selected from ginseng, CoQ10, vitamin B12, caffeine, caffeine beadlets, or a combination thereof. The red palm oil may be in an amount of about 10 mg to about 2000 mg. The ginseng may be in an amount of about 10 mg to about 1000 mg. The CoQ10 may be in an amount of about 0.01 mg to about 1000 mg. The vitamin B12 may be in an amount of about 10 mcg to about 1000 mcg. The caffeine or caffeine beadlets may be in an amount of about 1 mg to about 1000 mg.
In some embodiments, the oil is krill oil, and the ingredient is selected from vitamin D, vitamin D3, calcium, or a combination thereof. The krill oil may be in an amount of about 10 mg to about 2000 mg. The vitamin D or vitamin D3 may be in an amount of about 10 IU to about 3000 IU. The calcium may be in an amount of about 1 mg to about 1000 mg.
In some embodiments, the oil is an omega-3 oil, and the ingredient is a probiotic. The omega-3 oil may be in an amount of about 10 mg to about 2000 mg. The probiotic may be in an amount of about 1 million to about 100 million CFUs.
In some embodiments, the oil is krill oil, and the ingredient is selected from vitamin K2, glucosamine, collagen, UC2 collagen, or a combination thereof. The krill oil may be in an amount of about 10 mg to about 2000 mg. The vitamin K2 may be in an amount of about 0.01 mg to about 100 mg. The glucosamine may be in an amount of about 10 mg to about 1000 mg. The collagen or UC2 collagen may be in amount of about 1 mg to about 1000 mg.
In some embodiments, the oil is an omega-3 oil such as, for example, alpha-linolenic acid (ALA), and the ingredient is selected from caffeine, caffeine beadlets, or a combination thereof. The ALA may be in an amount of about 10 mg to about 2000 mg. The caffeine or caffeine beadlets may be in an amount of about 1 mg to about 1000 mg.
In some embodiments, the oil is ginger oil and the ingredient is curcumin. The ginger oil may be in an amount of about 10 mg to about 2000 mg, and the circumin may be in an amount of about 10 mg to about 1000 mg.
In some embodiments, the oil is an omega-3 oil, and the ingredient is selected from vitamin D, vitamin D3, vitamin E, folic acid, vitamin B2, vitamin B6, vitamin B12, vitamin C, iron, dicalcium phosphate, or a combination thereof. The omega-3 oil may be in an amount of about 10 mg to about 2000 mg. The vitamin D or vitamin D3 may be in an amount of about 10 IU to about 3000 IU. The vitamin E may be in an amount of about 1 IU to about 3000 IU. The folic acid may be in an amount of about 0.1 mcg to about 1000 mcg. The vitamin B2 may be in an amount of about 1 mg to about 1000 mg. The vitamin B6 may be in an amount of about 1 mg to about 1000 mg. The vitamin B12 may be in an amount of about 1 mcg to about 1000 mcg. The vitamin C may be in an amount of about 1 mg to about 1000 mg. The iron may be in an amount of about 1 mg to about 1000 mg. The dicalcium phosphate may be in an amount of about 1 mg to about 1000 mg.
In some embodiments, the oil is krill oil and the ingredient is selected from vitamin D, vitamin D3, vitamin K2, vitamin E, vitamin E tocotrienols, or a combination thereof. The krill oil may be in an amount of about 10 mg to about 2000 mg. The vitamin D or vitamin D3 may be in an amount of about 10 IU to about 3000 IU. The vitamin K2 may be in an amount of about 0.01 mg to about 100 mg. The vitamin E or vitamin E tocotrienols may be in an amount of about 10 mg to about 1000 mg.
In some embodiments, the oil is lavender oil, and the ingredient is selected from melatonin, passion flower, lemon, lemon extract, or a combination thereof. The lavender oil may be in an amount of about 10 mg to about 2000 mg. The melatonin may be in an amount of about 1 mg to about 1000 mg. The passion flower may be in an amount of about 10 mg to about 1000 mg. The lemon or lemon extract may be in an amount of about 10 mg to about 1000 mg.
In some embodiments, the oil is conjugated linoleic acid (CLA), and the ingredient is selected from piper betle leaf, dolichos bilforus seed extract, or a combination thereof, such as LOWAT. The CLA may be in an amount of about 10 mg to about 2000 mg. The piper betle leaf, dolichos bilforus seed extract, or combination thereof, such as LOWAT, may be in an amount of about 10 mg to about 1000 mg.
In some embodiments, the oil is krill oil, and the ingredient is aspirin. The krill oil may be in an amount of about 10 mg to about 2000 mg, and the aspirin may be in an amount of about 10 mg to about 500 mg.
In some embodiments, the first compartment and the second compartment each has sufficient volume to administer a therapeutically effective dose of the oil and the ingredient, respectively.
Table 1 below lists some possible combinations of ingredients which may be found in some embodiments. It is to be understood that any of the ingredients within Table 1 may be found in any combination, and may be found in either compartment of the capsule described herein. It is to be further understood that the embodiments described in Table 1 are not meant to be limiting, but are merely illustrative.

TABLE 1

First compartment	Second compartment

About 10 mg to about 500 mg of aspirin	About 10 mg to about 2000 mg of an oil
About 10 mg to about 500 mg of aspirin	About 10 mg to about 2000 mg of an
	omega-3 oil
About 10 mg to about 2000 mg of an	About 10 mg to about 1000 mg of CoQ10
omega-3 oil; and/or
About 10 mg to about 2000 mg of red
palm oil
About 10 mg to about 2000 mg of an	About 1 mg to about 100 mg of a statin;
omega-3 oil	and/or
	About 10 mg to about 1000 mg of CoQ10
About 10 mg to about 2000 mg of an	About 10 mcg to about 1000 mcg of
omega-3 oil	vitamin K2
About 10 mg to about 500 mg of alpha	About 10 mcg to about 1000 mcg of
linolenic acid	chromium; and/or
	About 10 mg to about 1000 mg of CoQ10
About 10 mg to about 1000 mg of saw	About 5 mcg to about 500 mcg of
palmetto oil	liothyronine sodium
About 10 mg to about 2000 mg of red	About 10 IU to about 3000 IU of vitamin
palm oil	D; and/or
	About 10 mcg to about 1000 mcg of
	vitamin K2; and/or
	About 1 mg to about 5000 mg of a
	multivitamin
About 10 mg to about 2000 mg krill oil	About 10 mg to about 1000 mg of CoQ10;
	and/or
	About 1 mg to about 5000 mg of a
	multivitamin
About 5 mcg to about 500 mcg of	About 10 mg to about 1000 mg of vitamin
triiodothyronine	B6; and/or
	About 10 mcg to about 1000 mcg of
	vitamin B12
About 10 mg to about 2000 mg of krill oil	About 10 mcg to about 1000 mcg of
	vitamin K2
About 10 mg to about 1000 mg of saw	About 5 mcg to about 500 mcg of
palmetto oil	triiodothyronine
About 10 mg to about 2000 mg of red	About 1 mg to about 30 mg of lutein;
palm oil	and/or
	About 1 mg to about 30 mg of lycopene;
	and/or
	About 0.01 mg to about 10 mg of biotin;
	and/or
	About 1 mcg to about 200 mcg of
	selenium (methionine); and/or
	About 1 mg to about 45 mg of zinc
	(glyconate)
About 10 mg to about 2000 mg of an	About 1 mg to about 500 mg of
omega-3 oil	frankincense; and/or
	About 10 mg to about 1000 mg of
	gymnema or gymnema extract; and/or
	About 10 mg to about 1000 mg of
	cinnamon; and/or
	About 10 mg to about 1000 mg of
	chromium (picolinate); and/or
	About 10 mg to about 1000 mg of vitamin
	B6; and/or
	About 10 mcg to about 1000 mcg of
	vitamin B12
About 10 mg to about 2000 mg of an	About 10 mg to about 1000 mg of resvida;
omega-3 oil	and/or
	About 1 mg to about 1000 mg of lipoic
	acid; and/or
	About 10 mg to about 1000 mg of CoQ10;
	and/or
	About 0.1 mcg to about 1000 mcg of folic
	acid; and/or
	About 10 mg to about 1000 mg of vitamin
	B6; and/or
	About 10 mcg to about 1000 mcg of
	vitamin B12
About 10 mg to about 2000 mg of krill oil;	About 10 mg to about 1000 mg of oleic
and/or	acid; and/or
About 10 mg to about 2000 mg of red	About 1 mg to about 1000 mg of linoleic
palm oil	acid; and/or
	About 1 mg to about 1000 mg of
	tocotrienols; and/or
	About 1 mg to about 1000 mg of
	tocopherols; and/or
	About 1 mg to about 1000 mg beta-
	carotene; and/or
	About 1 mg to about 1000 mg alpha-
	carotene; and/or
	About 0.1 mg to about 1000 mg of
	squalene; and/or
	About 1 mg to about 1000 mg of a plant
	sterol; and/or
	About 0.01 mg to about 1000 mg of
	CoQ10; and/or
	About 1 mg to about 5000 mg of a
	multivitamin
About 10 mg to about 2000 mg of krill oil;	About 1 mg to about 1000 mg of vitamin
and/or	C; and/or
About 10 mg to about 2000 mg of an	About 1 mg to about 1000 mg of zinc;
omega-3 oil, such as, for example,	and/or
docosahexaenoic acid (DHA)	About 1 mg to about 1000 mg of
	dicalcium phosphate; and/or
	About 10 IU to about 3000 IU of vitamin
	D; and/or
	About 10 mcg to about 1000 mcg of
	vitamin K; and/or
	About 0.1 mg to about 1000 mg of
	magnesium; and/or
	About 1 mg to about 1000 mg of calcium
About 10 mg to about 2000 mg of krill oil	About 1 mg to about 5000 mg of a
	multivitamin; and/or
	About 0.01 mg to about 1000 mg of
	CoQ10; and/or
	About 10 IU to about 4000 IU of vitamin
	A; and/or
	About 10 IU to about 3000 IU of vitamin
	D or vitamin D3; and/or
	About 10 IU to about 3000 IU of vitamin
	E; and/or
	About 10 mcg to about 1000 mcg of
	biotin; and/or
	About 0.1 mcg to about 1000 mcg of folic
	acid; and/or
	About 1 mg to about 1000 mg of niacin;
	and/or
	About 1 mg to about 1000 mg of
	panthothenic acid; and/or
	About 1 mg to about 1000 mg of vitamin
	B1; and/or
	About 1 mg to about 1000 mg of vitamin
	B2; and/or
	About 1 mg to about 1000 mg of vitamin
	B6; and/or
	About 10 mcg to about 1000 mcg of
	vitamin B12; and/or
	About 1 mg to about 1000 mg of vitamin
	C; and/or
	About 10 mcg to about 1000 mcg of
	vitamin K; and/or
	About 1 mg to about 1000 mg of calcium;
	and/or
	About 1 mcg to about 1000 mcg of
	chromium; and/or
	About 0.1 mg to about 100 mg of copper;
	and/or
	About 0.01 mg to about 100 mg of iodine;
	and/or
	About 0.1 mg to about 1000 mg of
	magnesium; and/or
	About 0.1 mg to about 1000 mg of
	magnesium stearate; and/or
	About 0.1 mg to about 100 mg of
	manganese; and/or
	About 1 mcg to about 1000 mcg of
	molybdenum; and/or
	About 1 mg to about 100 mg of
	phosphorous; and/or
	About 1 mcg to about 200 mcg of
	selenium; and/or
	About 1 mg to about 1000 mg of zinc
About 10 mg to about 2000 mg of red	About 10 mg to about 1000 mg of
palm oil	ginseng; and/or
	About 0.01 mg to about 1000 mg of
	CoQ10; and/or
	About 10 mcg to about 1000 mcg of
	vitamin B12; and/or
	About 1 mg to about 1000 mg of caffeine
About 10 mg to about 2000 mg of krill oil	About 10 IU to about 3000 IU of vitamin
	D or vitamin D3; and/or
	About 1 mg to about 1000 mg of calcium
About 10 mg to about 2000 mg of an	About 1 million to about 100 billion CFUs
omega-3 oil	of a probiotic
About 10 mg to about 2000 mg of krill oil	About 0.01 mg to about 100 mg of
	vitamin K2; and/or
	About 10 mg to about 1000 mg of
	glucosamine; and/or
	About 1 mg to about 1000 mg of UC2
	collagen
About 10 mg to about 2000 mg of an	About 1 mg to about 1000 mg of caffeine
omega-3 oil, such as, for example,	or caffeine beadlets
alpha-linolenic acid (ALA)
About 10 mg to about 2000 mg of ginger	About 10 mg to about 1000 mg of
oil	curcumin
About 10 mg to about 2000 mg of an	About 10 IU to about 3000 IU of vitamin
omega-3 oil	D or vitamin D3; and/or
	About 1 IU to about 3000 IU of vitamin
	E; and/or
	About 0.1 mcg to about 1000 mcg of folic
	acid; and/or
	About 1 mg to about 1000 mg of vitamin
	B2; and/or
	About 1 mg to about 1000 mg of vitamin
	B6; and/or
	About 1 mcg to about 1000 mcg of
	vitamin B12; and/or
	About 1 mg to about 1000 mg of vitamin
	C; and/or
	About 1 mg to about 1000 mg of iron;
	and/or
	About 1 mg to about 1000 mg of
	dicalcium phosphate
About 10 mg to about 2000 mg of krill oil	About 10 IU to about 3000 IU of vitamin
	D or vitamin D3; and/or
	About 0.01 mg to about 100 mg of
	vitamin K2; and/or
	About 10 mg to about 1000 mg of vitamin
	E tocotrienols
About 10 mg to about 2000 mg of	About 1 mg to about 1000 mg of
lavender oil	melatonin; and/or
	About 10 mg to about 1000 mg of passion
	flower; and/or
	About 10 mg to about 1000 mg of lemon
	or lemon extract
About 10 mg to about 2000 mg of	About 10 mg to about 1000 mg of a
conjugated linoleic acid (CLA)	combination of piper betle leaf and/or
	dolichos biflorus seed extract, such as
	LOWAT
About 10 mg to about 2000 mg of krill oil	About 10 mg to about 500 mg of aspirin

Table 2 below shows various dimensions of standard and elongated TORPAC capsule sizes, which may be used in some embodiments described herein.

TABLE 2

CAPSULE SIZE	000	00E	00	00LQ	0E	0	1	2	3	4

WEIGHT
Average Weight (mg)	158	130	123	132	107	99	76	61	48	38
tolerance	±10	±10	±7	±4	±7	±6	±5	±4	±3	±3
CAPACITY
Volume Capacity (ml)	1.37	1.02	0.95	0.95	0.77	0.68	0.48	0.36	0.27	0.20

density of dosing powder

Weight Capacity (mg)

0.6 g/ml	822	612	570	570	462	408	288	216	162	120
0.8 g/ml	1096	816	760	760	616	544	384	288	216	160
1.0 g/ml	1370	1020	950	950	770	680	480	360	270	200
1.2 g/ml	1644	1224	1140	1140	924	816	576	432	324	240
OVERALL CLOSED
LENGTH
(mm)	26	25.4	23.4	23.4	23.4	21.6	19.4	17.6	15.7	14.3
tolerance	±0.3	±0.3	±0.3	±0.3	±0.3	±0.3	±0.3	±0.3	±0.3	±0.3
(inches)	1.024	1	0.921	0.921	0.921	0.85	0.764	0.693	0.618	0.563
tolerance	±0.012	±0.012	±0.012	±0.012	±0.012	±0.012	±0.012	±0.012	±0.012	±0.012
INDIVIDUAL LENGTHS
(CAP & BODY)
CAP (mm)	12.9	12.94	11.8	11.8	11.9	10.85	9.85	8.8	8	7.2
tolerance	±0.35	±0.35	±0.35	±0.35	±0.35	±0.35	±0.35	±0.35	±0.35	±0.35
BODY (mm)	21.9	22.38	20.1	20.1	20	18.45	16.4	15.15	13.45	12.1
tolerance	±0.35	±0.35	±0.35	±0.35	±0.35	±0.35	±0.35	±0.35	±0.35	±0.35
CAP (inches)	0.508	0.509	0.464	0.464	0.468	0.427	0.388	0.346	0.315	0.283
tolerance	±0.014	±0.014	±0.014	±0.014	±0.014	±0.014	±0.014	±0.014	±0.014	±0.014
BODY (inches)	0.862	0.881	0.791	0.791	0.787	0.726	0.646	0.596	0.529	0.476
tolerance	±0.014	±0.014	±0.014	±0.014	±0.014	±0.014	±0.014	±0.014	±0.014	±0.014
EXTERNAL DIAMETER
CAP (mm)	9.94	8.58	8.56	8.56	7.66	7.65	6.96	6.39	5.85	5.33
BODY (mm)	9.55	8.25	8.23	8.23	7.35	7.35	6.63	6.12	5.60	5.08
CAP (inches)	0.391	0.338	0.337	0.337	0.302	0.301	0.274	0.252	0.23	0.21
BODY (inches)	0.376	0.325	0.324	0.324	0.289	0.289	0.261	0.241	0.22	0.2

Recommended Storage Conditions: 59°-77° F./15°-25° C. RH 35-65%

Table 3 below shows additional dimensions of standard and elongated TORPAC capsule sizes, which may be used in some embodiments described herein.

TABLE 3

	Typical Fill Weights
	(mg)
	Actual Fill Weights
	may vary and depend
	on powder					Single	Weight
	characteristics		Locked		Cut	Wall	(Avg. of
	Powder Density	Volume	Length	External	Length	Thickness	100)

	0.45	0.70	1.00	Theoretical	+/−0.76	Tolerance	Diam.	+/−0.51	+/−0.03	+/−10%
Size	Light	Typical	Heavy	(ml)	(mm)	Component	(mm)	(mm)	(mm)	(mg)

000	615	960	1370	1.37	26.14	Cap	9.91	12.95	0.112	163
						Body	9.55	22.20	0.110
00	430	665	950	0.95	23.30	Cap	8.53	11.74	0.109	118
						Body	8.18	20.22	0.107
0	305	475	680	0.68	21.70	Cap	7.65	10.72	0.107	96
						Body	7.34	18.44	0.104
1	225	350	500	0.50	19.40	Cap	6.91	9.78	0.104	76
						Body	6.63	16.61	0.102
2	165	260	370	0.37	18.00	Cap	6.35	8.94	0.102	61
						Body	6.07	15.27	0.099
3	135	210	300	0.30	15.90	Cap	5.82	8.08	0.092	48
						Body	5.56	13.59	0.890
4	95	145	210	0.21	14.30	Cap	5.31	7.21	0.096	38
						Body	5.05	12.19	0.091
5	60	90	130	0.13	11.10	Cap	4.91	6.20	0.089	28
						Body	4.68	9.32	0.086

Although the present invention has been described in considerable detail with reference to certain preferred embodiments thereof, other versions are possible. Therefore, the spirit and scope of the appended claims should not be limited to the description and the preferred versions contained within this specification. Modifications and improvements to the disclosed embodiments will be apparent to those skilled in the art in light of this disclosure, and are intended to fall within the scope of the pending claims.

Claims

1.-22. (canceled)

23. A multi-compartment capsule comprising:

a body comprising an open end, a closed end, and inner surface, and an outer surface;

a diaphragm having a bottom and one or more peripheral sidewalls extending from the bottom, wherein the one or more peripheral sidewalls contact the body to form a first liquid-tight compartment between the diaphragm and the closed end of the body; and

a cap contacting the body at the open end to form a second liquid-tight compartment between the diaphragm and the cap,

wherein (i) a first of the first liquid-tight compartment and the second liquid-tight compartment contains an oil, and (ii) a second of the first liquid-tight compartment and the second liquid-tight compartment contains an oil-soluble ingredient, and

wherein the first liquid-tight compartment and the second liquid-tight compartment are configured to simultaneously release the oil and the oil-soluble ingredient during digestion of the multi-compartment capsule.

24. The multi-compartment capsule of claim 23, wherein the one or more peripheral sidewalls contact the body to form a hermetic seal between the first liquid-tight compartment and the second liquid-tight compartment.

25. The multi-compartment capsule of claim 23, wherein the oil-soluble ingredient is selected from the group consisting of a powder, a granule, a semi-solid, a beadlet, a microbead, and a combination thereof.

26. The multi-compartment capsule of claim 23, wherein the oil comprises an omega-3 oil comprising an eicosapentaenoic acid and the oil-soluble ingredient comprises a statin.

27. The multi-compartment capsule of claim 23, wherein the oil is selected from the group consisting of a cannabis oil and hemp oil, and

wherein the oil-soluble ingredient comprises an herbal extract.

28. The multi-compartment capsule of claim 23, wherein the one or more peripheral sidewalls contact the inner surface of the body to form the first liquid-tight compartment.

29. The multi-compartment capsule of claim 23, wherein the cap contacts the outer surface of the body to form the second liquid-tight compartment.

30. The multi-compartment capsule of claim 23, wherein at least a portion of the body and at least a portion of the cap comprise substantially the same material and substantially the same thickness.

31. The multi-compartment capsule of claim 23, wherein the oil is selected from the group consisting of omega-3 oil, red palm oil, fish oil, krill oil, walnut oil, saw palmetto oil, castor oil, garlic oil, flaxseed oil, canola oil, soybean oil, cannabis oil, argan oil, coconut oil, peppermint oil, evening primrose oil, oregano oil, emu oil, cod liver oil, algae oil, grape seed oil, rose oil, clove oil, vitamin E oil, blueberry seed oil, raspberry seed oil, pumpkin seed oil, hemp oil, alpha-linolenic acid, conjugated linoleic acid, docosahexaenoic acid, eicosapentaenoic acid, ginger oil, lavender oil, and combinations thereof.

32. A multi-compartment capsule comprising:

wherein (i) a first of the first liquid-tight compartment and the second liquid-tight compartment contains an oil, and (ii) a second of the first liquid-tight compartment and the second liquid-tight compartment contains an oil-suspendable ingredient, and

wherein the first liquid-tight compartment and the second liquid-tight compartment are configured to simultaneously release the oil and the oil-suspendable ingredient during digestion of the multi-compartment capsule.

33. The multi-compartment capsule of claim 32, wherein the one or more peripheral sidewalls contact the body to form a hermetic seal between the first liquid-tight compartment and the second liquid-tight compartment.

34. The multi-compartment capsule of claim 32, wherein the oil-suspendable ingredient is selected from the group consisting of a powder, a granule, a semi-solid, a beadlet, a microbead, and a combination thereof.

35. The multi-compartment capsule of claim 32, wherein the one or more peripheral sidewalls contact the inner surface of the body to form the first liquid-tight compartment.

36. The multi-compartment capsule of claim 32, wherein the cap contacts the outer surface of the body to form the second liquid-tight compartment.

37. The multi-compartment capsule of claim 32, wherein at least a portion of the body and at least a portion of the cap comprise substantially the same material and substantially the same thickness.

38. The multi-compartment capsule of claim 32, wherein the oil is selected from the group consisting of omega-3 oil, red palm oil, fish oil, krill oil, walnut oil, saw palmetto oil, castor oil, garlic oil, flaxseed oil, canola oil, soybean oil, cannabis oil, argan oil, coconut oil, peppermint oil, evening primrose oil, oregano oil, emu oil, cod liver oil, algae oil, grape seed oil, rose oil, clove oil, vitamin E oil, blueberry seed oil, raspberry seed oil, pumpkin seed oil, hemp oil, alpha-linolenic acid, conjugated linoleic acid, docosahexaenoic acid, eicosapentaenoic acid, ginger oil, lavender oil, and combinations thereof

39. A method of manufacturing a multi-compartment capsule, the method comprising:

providing a body comprising an open end, a closed end, and inner surface, and an outer surface;

inserting an oil within the body such that the oil is adjacent the closed end;

inserting a diaphragm within the body, wherein the diaphragm comprises a bottom and one or more peripheral sidewalls extending from the bottom that contact the body to form a first liquid-tight compartment between the diaphragm and the closed end of the body, wherein the oil is contained with the first liquid-tight compartment;

inserting an oil-soluble ingredient within the diaphragm such that the oil-soluble ingredient is adjacent the bottom;

mounting a cap on the body at the open end to form a second liquid-tight compartment between the diaphragm and the cap, wherein the oil-soluble ingredient is contained with the second liquid-tight compartment,

40. A method of manufacturing a multi-compartment capsule, the method comprising:

inserting an oil within the body such that the oil is adjacent the closed end;

inserting an oil-suspendable ingredient within the diaphragm such that the oil-suspendable ingredient is adjacent the bottom;

mounting a cap on the body at the open end to form a second liquid-tight compartment between the diaphragm and the cap, wherein the oil-suspendable ingredient is contained with the second liquid-tight compartment,

41. A multi-compartment capsule comprising:

wherein (i) a first of the first liquid-tight compartment and the second liquid-tight compartment contains a primary ingredient, and (ii) a second of the first liquid-tight compartment and the second liquid-tight compartment contains a secondary ingredient, and

wherein the first liquid-tight compartment and the second liquid-tight compartment are configured to simultaneously release the primary ingredient and the secondary ingredient during digestion of the multi-compartment capsule.

42. The multi-compartment capsule of claim 41, wherein the secondary ingredient improves bioavailability of the primary ingredient when simultaneously released during digestion of the multi-compartment capsule.

43. The multi-compartment capsule of claim 42, wherein the secondary ingredient increases absorption of the primary ingredient during or after digestion of the multi-compartment capsule.

44. The multi-compartment capsule of claim 41, wherein the primary ingredient comprises curcumin and the secondary ingredient comprises piper or a component thereof.

45. The multi-compartment capsule of claim 44, wherein the secondary ingredient comprises piper betle leaf.

46. The multi-compartment capsule of claim 41, wherein the primary ingredient is selected from the group consisting of zinc and copper, and

wherein the secondary ingredient comprises vitamin C.

47. The multi-compartment capsule of claim 41, wherein the primary ingredient is selected from the group consisting of vitamin D3, and

wherein the secondary ingredient comprises magnesium.

48. The multi-compartment capsule of claim 41, wherein each of the primary ingredient and the secondary ingredient is selected from the group consisting of an oil, a liquid, a powder, a granule, a semi-solid, a gel, a beadlet, a microbead, and a combination thereof.