US20190336598A1 - Methods for modulating inflammasome activity and inflammation in the lung - Google Patents
Methods for modulating inflammasome activity and inflammation in the lung Download PDFInfo
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- US20190336598A1 US20190336598A1 US16/474,708 US201716474708A US2019336598A1 US 20190336598 A1 US20190336598 A1 US 20190336598A1 US 201716474708 A US201716474708 A US 201716474708A US 2019336598 A1 US2019336598 A1 US 2019336598A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Definitions
- EV from TBI mice induced alveolar morphological changes (decreased alveolar size) and infiltration of inflammatory cells as determined by H&E staining ( FIG. 7G ).
- ALI score is significantly increased in EV delivered from injured mice compared to uninjured mice ( FIG. 7H ).
- binding fragments include: (i) an Fab fragment consisting of VL, VH, CL and CH1 domains (Ward, E. S. et al., (1989) Nature 341, 544-546); (ii) an Fd fragment consisting of the VH and CH1 domains (McCafferty et al., (1990) Nature, 348, 552-554); (iii) an Fv fragment consisting of the VL and VH domains of a single antibody (Holt et al., (2003) Trends in Biotechnology 21, 484-490); (iv) a dAb fragment (Ward, E. S.
- NALP1 and NLRP1 mean an expression product of an NALP or NLRP1 gene or isoforms; or a protein that shares at least 65% (but preferably 75, 80, 85, 90, 95, 96, 97, 98, or 99%) amino acid sequence identity with NALP (e.g., accession number(s) AAH51787, NP_001028225, NP_127500, NP_127499, NP_127497, NP055737) and displays a functional activity of NALP1.
- accession number(s) AAH51787, NP_001028225, NP_127500, NP_127499, NP_127497, NP055737 displays a functional activity of NALP1.
- Such antibodies may be of any immunoglobulin class including IgG, IgM, IgE, IgA, GILD and any subclass thereof
- a hybridoma producing a monoclonal antibody of the present invention may be cultivated in vitro, in situ or in vivo.
- this Example showed that AIM2 inflammasome signaling plays a central role in the pathomechanism of lung injury after TBI and demonstrates a mechanism of TBI-induced ALI involving EV-mediated inflammasome signaling.
- EV-mediated inflammasome signaling can play a central role involving a Neuronal-Respiratory-Inflammatory Axis. Therefore, targeting this axis with antibodies against inflammasome proteins or drugs that block EV uptake may provide a therapeutic approach in Neurotrauma-induced ALI in all areas of critical care medicine.
- the disclosed therapeutic strategies may be useful for the treatment of inflammatory diseases of the lung in general.
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US16/474,708 US20190336598A1 (en) | 2016-12-29 | 2017-12-28 | Methods for modulating inflammasome activity and inflammation in the lung |
Applications Claiming Priority (3)
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US201662440180P | 2016-12-29 | 2016-12-29 | |
PCT/US2017/068713 WO2018126009A1 (en) | 2016-12-29 | 2017-12-28 | Method for modulating inflammasome activity and inflammation in the lung |
US16/474,708 US20190336598A1 (en) | 2016-12-29 | 2017-12-28 | Methods for modulating inflammasome activity and inflammation in the lung |
Related Parent Applications (1)
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PCT/US2017/068713 A-371-Of-International WO2018126009A1 (en) | 2016-12-29 | 2017-12-28 | Method for modulating inflammasome activity and inflammation in the lung |
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US17/358,582 Continuation US20210324065A1 (en) | 2016-12-29 | 2021-06-25 | Methods for modulating inflammasome activity and inflammation in the lung |
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US20190336598A1 true US20190336598A1 (en) | 2019-11-07 |
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Family Applications (5)
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US16/474,708 Abandoned US20190336598A1 (en) | 2016-12-29 | 2017-12-28 | Methods for modulating inflammasome activity and inflammation in the lung |
US16/026,482 Active US10703811B2 (en) | 2016-12-29 | 2018-07-03 | Methods and compositions for treating multiple sclerosis |
US16/847,054 Active US10961306B2 (en) | 2016-12-29 | 2020-04-13 | Methods for treating lung inflammation with an anti-ASC antibody |
US16/856,407 Active US11174307B2 (en) | 2016-12-29 | 2020-04-23 | Methods and compositions for treating virus-associated inflammation |
US17/358,582 Abandoned US20210324065A1 (en) | 2016-12-29 | 2021-06-25 | Methods for modulating inflammasome activity and inflammation in the lung |
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US16/026,482 Active US10703811B2 (en) | 2016-12-29 | 2018-07-03 | Methods and compositions for treating multiple sclerosis |
US16/847,054 Active US10961306B2 (en) | 2016-12-29 | 2020-04-13 | Methods for treating lung inflammation with an anti-ASC antibody |
US16/856,407 Active US11174307B2 (en) | 2016-12-29 | 2020-04-23 | Methods and compositions for treating virus-associated inflammation |
US17/358,582 Abandoned US20210324065A1 (en) | 2016-12-29 | 2021-06-25 | Methods for modulating inflammasome activity and inflammation in the lung |
Country Status (15)
Country | Link |
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US (5) | US20190336598A1 (zh) |
EP (2) | EP3562506A4 (zh) |
JP (3) | JP2020503345A (zh) |
KR (1) | KR20200013630A (zh) |
CN (1) | CN110461356A (zh) |
AU (1) | AU2017386550A1 (zh) |
BR (1) | BR112019013463A2 (zh) |
CA (2) | CA3048864A1 (zh) |
CO (1) | CO2019008087A2 (zh) |
IL (1) | IL267685A (zh) |
MX (1) | MX2019007916A (zh) |
PH (1) | PH12019501549A1 (zh) |
RU (1) | RU2019123160A (zh) |
SG (1) | SG10202106385XA (zh) |
WO (2) | WO2018126009A1 (zh) |
Cited By (2)
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US10703811B2 (en) | 2016-12-29 | 2020-07-07 | University Of Miami | Methods and compositions for treating multiple sclerosis |
US11840565B2 (en) | 2016-12-29 | 2023-12-12 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
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JP2021528092A (ja) * | 2018-07-03 | 2021-10-21 | ユニバーシティ オブ マイアミ | インフラマソームに関連する疾患又は病態を治療するための組成物及び方法 |
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WO2016182660A1 (en) * | 2015-05-12 | 2016-11-17 | The Regents Of The University Of California | Peptide treatment for inflammation and fibrosis |
EP3337782A4 (en) | 2015-08-17 | 2019-04-03 | TWI Biotechnology, Inc. | DIACEREIN OR ITS ANALOGUES FOR INHIBITING THE EXPRESSION OF ASC AND NLRP3 PROTEINS, AND / OR THE FORMATION OF THE INFLAMMASOME COMPLEX NLRP3 |
KR101948048B1 (ko) | 2016-12-08 | 2019-02-14 | 한양대학교 에리카산학협력단 | 톡소포자충 gra7 항원 유래 재조합 단백질을 유효성분으로 포함하는 결핵 예방 또는 치료용 약학 조성물 |
EP3562506A4 (en) | 2016-12-29 | 2021-01-06 | University of Miami | METHOD OF MODULATION OF INFLAMMATORY SOMACTIVITY AND INFLAMMATION OF THE LUNG |
AU2018336897A1 (en) | 2017-09-20 | 2020-04-30 | University Of Miami | Method for detecting inflammasome proteins as biomarkers of neurological disorders |
JP2021528092A (ja) | 2018-07-03 | 2021-10-21 | ユニバーシティ オブ マイアミ | インフラマソームに関連する疾患又は病態を治療するための組成物及び方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10703811B2 (en) | 2016-12-29 | 2020-07-07 | University Of Miami | Methods and compositions for treating multiple sclerosis |
US10961306B2 (en) | 2016-12-29 | 2021-03-30 | University Of Miami | Methods for treating lung inflammation with an anti-ASC antibody |
US11174307B2 (en) | 2016-12-29 | 2021-11-16 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
US11840565B2 (en) | 2016-12-29 | 2023-12-12 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
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CA3176518A1 (en) | 2021-10-28 |
RU2019123160A (ru) | 2021-01-29 |
US20200308262A1 (en) | 2020-10-01 |
CN110461356A (zh) | 2019-11-15 |
US10703811B2 (en) | 2020-07-07 |
WO2018126009A1 (en) | 2018-07-05 |
CA3048864A1 (en) | 2018-07-05 |
SG10202106385XA (en) | 2021-07-29 |
EP4139348A4 (en) | 2024-08-14 |
US20200347124A1 (en) | 2020-11-05 |
BR112019013463A2 (pt) | 2020-01-07 |
US11174307B2 (en) | 2021-11-16 |
JP2023016835A (ja) | 2023-02-02 |
JP2023515271A (ja) | 2023-04-12 |
AU2017386550A1 (en) | 2019-08-08 |
CO2019008087A2 (es) | 2019-10-21 |
RU2019123160A3 (zh) | 2021-01-29 |
US20190002550A1 (en) | 2019-01-03 |
IL267685A (en) | 2019-08-29 |
EP3562506A1 (en) | 2019-11-06 |
WO2021217004A2 (en) | 2021-10-28 |
US10961306B2 (en) | 2021-03-30 |
US20210324065A1 (en) | 2021-10-21 |
PH12019501549A1 (en) | 2020-02-24 |
JP2020503345A (ja) | 2020-01-30 |
MX2019007916A (es) | 2019-12-05 |
KR20200013630A (ko) | 2020-02-07 |
EP3562506A4 (en) | 2021-01-06 |
WO2021217004A3 (en) | 2021-12-16 |
EP4139348A2 (en) | 2023-03-01 |
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