US20170156908A1 - Methods and devices for delivering or delaying lipids within a duodenum - Google Patents

Methods and devices for delivering or delaying lipids within a duodenum Download PDF

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US20170156908A1
US20170156908A1 US15384130 US201615384130A US2017156908A1 US 20170156908 A1 US20170156908 A1 US 20170156908A1 US 15384130 US15384130 US 15384130 US 201615384130 A US201615384130 A US 201615384130A US 2017156908 A1 US2017156908 A1 US 2017156908A1
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flow reduction
device
flow
spine
reduction element
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Abandoned
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US15384130
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James T. McKinley
Zhenyong Keck
Fiona M. Sander
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Endosphere Inc
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Endosphere Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013Implantable devices or invasive measures
    • A61F5/0076Implantable devices or invasive measures preventing normal digestion, e.g. Bariatric or gastric sleeves
    • A61F5/0079Pyloric or esophageal obstructions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00Drainage appliances for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002Implant devices for drainage of body fluids from one part of the body to another

Abstract

Devices and methods described include a flow reduction device adapted and configured for use within the duodenum of a mammal having a spine, a first atraumatic feature, a second atraumatic feature, and a flow reduction element having a proximal end, a distal end, an interior portion, an exterior portion and a variable porosity between the proximal end and the distal end. One aspect of the device includes a spine having a proximal end and a distal end, an atraumatic feature positioned on at least one of the proximal end and the distal end of the spine, and a flow reduction element positioned along the spine and having a variable porosity along its length.

Description

    CROSS REFERENCE TO RELATED APPLICATIONS
  • This application is a continuation of U.S. patent application Ser. No. 14/793,454, filed Jul. 7, 2015, titled “METHODS AND DEVICES FOR DELIVERING OR DELAYING LIPIDS WITHIN A DUODENUM,” now U.S. Patent Application Publication No. 2015-0305906, which is a continuation of U.S. patent application Ser. No. 13/769,097, filed Feb. 15, 2013, entitled “METHODS AND DEVICES FOR DELIVERING OR DELAYING LIPIDS WITHIN A DUODENUM,” now U.S. Pat. No. 9,072,861, which is a continuation of U.S. patent application Ser. No. 12/999,180, filed Jan. 31, 2011, entitled “METHODS AND DEVICES FOR DELIVERING OR DELAYING LIPIDS WITHIN A DUODENUM,” now Publication No. 2011-0137227, which is a 35 U.S.C. §371 National Phase Application of International Patent Application No. PCT/US2009/049586, filed Jul. 2, 2009, entitled “METHODS AND DEVICES FOR DELIVERING OR DELAYING LIPIDS WITHIN A DUODENUM,” now Publication No. WO 2010/003097, which claims the benefit of priority of U.S. Provisional Patent Application No. 61/077,579, filed Jul. 2, 2008, entitled “METHODS AND DEVICES FOR DELIVERING OR DELAYING LIPIDS WITHIN A DUODENUM.” PCT/US2009/049586 is also a continuation-in-part of International Patent Application No. PCT/US2008/070226, filed Jul. 16, 2008, entitled “CONFORMATIONALLY-STABILIZED INTRALUMINAL DEVICE FOR MEDICAL APPLICATIONS,” now Publication No. WO 2009/012335 A1, the entirety of each of these applications is incorporated herein by reference in its entirety.
  • Various aspects of the design, function, deployment, operation and delivery of conformal flow reduction devices for use in the duodenum are described in the following related applications: U.S. Provisional Patent Application No. 60/950,071, filed Jul. 16, 2007, entitled “CONFORMATIONALLY-STABILIZED INTRALUMINAL DEVICE FOR MEDICAL APPLICATIONS,” now International Patent Application No. PCT/US2008/070226, filed Jul. 16, 2008, entitled “A CONFORMATIONALLY-STABILIZED INTRALUMINAL DEVICE FOR MEDICAL APPLICATIONS,” now Publication No. WO 2009/012335; U.S. patent application Ser. No. 10/999,410, filed Nov. 30, 2004, entitled “METHOD AND APPARATUS FOR REDUCING OBESITY,” now U.S. Pat. No. 7,931,693; U.S. patent application Ser. No. 11/300,283, filed Dec. 15, 2005, entitled “METHODS AND DEVICES TO CURB APPETITE AND/OR REDUCE FOOD INTAKE,” now U.S. Pat. No. 8,147,561; and U.S. patent application Ser. No. 11/807,107, filed May 25, 2007, entitled “METHODS AND DEVICES TO CURB APPETITE AND/OR REDUCE FOOD INTAKE,” now Publication No. 2007-0293885.
  • INCORPORATION BY REFERENCE
  • All publications and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.
  • BACKGROUND
  • Obesity and type 2 diabetes are diseases of insufficient or deficient regulation. We know from human studies that the small intestine plays a critical role in both energy and glucose homeostasis: when the duodenum is exposed to lipids, appetite is diminished and native (liver) glucose production is down-regulated. Previously we have invented a device that can be implanted into the duodenum and remain in place; we have described devices and methods for slowing the passage of food through the duodenum to cause increased tissue-nutrient contact, thereby causing amplified hormonal signaling from the duodenum; and, we have invented methods and devices for delivering chemicals, drugs or other compounds to the duodenum.
  • What is needed are devices and/or methods for additional lipid uptake, delaying ingesta passage/prolonging ingesta contact, delivering or providing lipids or other appetite and glucose reducing nutrients and/or combinations of these characteristics.
  • SUMMARY OF THE DISCLOSURE
  • In one aspect of the present invention, there is provided a device adapted and configured for use within the duodenum of a mammal. The device has a spine having a proximal end and a distal end; an atraumatic feature positioned on at least one of the proximal end and the distal end of the spine; and, positioned along the spine, a flow reduction element having variable porosity along its length. In one embodiment, the variable porosity of the flow reduction element is selected so that a portion of a flow over the proximal end of the flow reduction element flows into an interior portion of the flow reduction element. In one embodiment, the variable porosity of the flow reduction element is selected so that flow within an interior of the flow reduction element is at least partially inhibited from flowing through the distal portion of the variable porosity structure. In one embodiment, the proximal portion of the flow reduction element comprises a material, a mesh or a braid having a porosity or altered to provide a porosity selected to permit a flow into an interior portion of the flow reduction element. In one embodiment, the distal portion of the flow reduction element comprises a material, a mesh or a braid having a porosity or altered to provide a porosity selected to at least partially inhibit a flow from within an interior portion of the flow reduction element. In one embodiment, the length of the spine is selected so when the atraumatic feature is positioned in a stomach the flow reduction element is positioned on the spine and distal to a pylorus. In one embodiment, the length of the spine is selected so when the atraumatic feature is positioned in a stomach the distal end of the spine is in the fourth portion of the duodenum and the flow reduction element is positioned within a portion of the duodenum. In one embodiment, there is also a flow reduction element having a non-variable porosity along its length. In one embodiment, there is also a feature on the spine positioned to restrict movement of the flow reduction element relative to the spine.
  • In still another aspect of the present invention, there is provided a device adapted and configured for use within the duodenum of a mammal. The device has a spine with a length, a proximal end and a distal end; a first atraumatic feature positioned adjacent to the spine proximal end; a second atraumatic feature positioned adjacent to the spine distal end wherein the length of the spine is selected so that when the first atraumatic feature is in the stomach the second atraumatic feature is in the fourth portion of the duodenum; and a flow reduction element having a proximal end, a distal end, an interior portion, an exterior portion and a variable porosity between the proximal end and the distal end. In one embodiment, the porosity of the proximal end is selected to the allow flow to pass from the exterior portion to the interior portion. In one embodiment, the porosity of the distal end is selected to impede flow from the interior portion to the exterior portion. In one embodiment, the proximal portion is more porous than the distal portion. In one embodiment, the proximal end has a porous structure configured to permit flow into the interior portion and the distal end has a solid portion to retain material within the interior portion. In one embodiment, there is provided another flow reduction element between the proximal and distal ends of the spine. In one embodiment, the another flow reduction element has variable porosity between the proximal and distal ends of the flow reduction element. In one embodiment, the length of the spine is selected so that when the first atraumatic feature is positioned in a stomach the second atraumatic feature is positioned within the duodenum and adjacent to the first atraumatic feature. In one embodiment, the length of the spine is selected so that when the first atraumatic feature is positioned in a stomach the second atraumatic feature is positioned within the duodenum and in proximity to the ligament of Treitz.
  • In still another aspect, there is provided a method for adjusting the passage of ingesta through the duodenum of a mammal by placing the distal end of a flow reduction device in the duodenum of a mammal; placing the proximal end of the flow reduction device in a stomach of the mammal; expanding within the duodenum of the mammal a variable porosity flow reduction element supported by the flow reduction device; and directing at least a portion of the flow of ingesta through the duodenum through the proximal end of the variable porosity flow reduction element and into an interior portion of the variable porosity flow reduction element. In one embodiment, there is also provided a method retaining a portion of the ingesta within the interior portion of the variable porosity flow reduction element until the ingesta is pushed out of the interior portion by peristaltic action of the duodenum. In still another embodiment, there is provided a method of adjusting the passage of ingesta wherein the ingesta is pushed out of the interior portion by passing through a distal portion of the variable porosity flow reduction element. In still another alternative method for adjusting the passage of ingesta, the ingesta is pushed out of the interior portion by passing through the proximal portion and thereafter passing around the variable porosity flow reduction element.
  • In another aspect, the flow reduction elements positioned along the device backbone could be coated with, manufactured from or contain lipid-philic materials. For example, one or more of the flow reduction elements of the intraduodenal device could be manufactured from a lipid absorbing or adsorbing material. A flow reduction element manufactured in this way will attract and collect lipids from passing ingesta and hold the lipids for a period of time. The length of time that the lipids will remain attached to the flow reduction element will vary based on a number of factors. For example, the flow reduction element may exude the lipids as peristalsis continues to squeeze the device. The prolonged presence of and/or sustained release of lipids within the duodenum is believed to benefit and in some cases to increase hormonal regulation. It is to be appreciated that embodiments of the present invention provide prolonged presence of and/or sustained release of lipids within the duodenum through the use of one or more of: making flow reduction elements and/or other components of the flow reduction device (i.e., any of the components of FIG. 1 for example) at least partially or even completely from one or more lipid-philic materials; coating flow reduction elements and/or other components of the flow reduction device entirely or at least partially form lipid-philic materials; and/or placing within a flow reduction element, or attaching to a component of the flow reduction device an additional element or component formed from or at least partially coated with a lipid-philic material.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a prospective view of a device for use in the duodenum.
  • FIG. 2 is an enlarged view of one of the flow reduction elements of FIG. 1 showing the upper and lower portions of the element;
  • FIG. 2A is an enlarged view of a material used to provide variable porosity to a flow portion of a flow reduction element;
  • FIG. 2B is an enlarged view of a solid or semi permeable sheet where a pattern of holes are used to provided variable porosity to a portion of a flow reduction element;
  • FIG. 3 illustrates a flow reduction element embodiment where more of the flow reduction device is utilized for allowing flow through the use of a larger proximal portion having a more porous construction and a smaller distal portion having a less porous construction;
  • FIG. 4 illustrates a flow reduction element embodiment where more of the flow reduction device is utilized for preventing flow than for allowing flow through the use of a smaller proximal portion having a more porous construction and a larger distal portion having a less porous construction.
  • DETAILED DESCRIPTION
  • The present application relates to methods and devices for providing a sense of fullness/satiety and/or glucose production inhibition. The devices and methods described herein provide for additional lipid presence in the duodenum by delaying ingesta passage/prolonging ingesta contact, delivering or providing lipids or other satiety and/or glucose reducing nutrients and/or combinations thereof.
  • Lipids can be generally defined as substances such as a fat, oil or wax that dissolve in alcohol but not in water. Lipids contain carbon, hydrogen and oxygen but have far less oxygen proportionally than carbohydrates. They serve as a source of fuel and are an important constituent of the structure of cells. As used herein, lipids refer to any of fatty acids, glycerides, complex lipids and nonglycerides. Fatty acids include both saturated and unsaturated. Glycerides include, for example, neutral phosphoglycerides. Complex lipids are lipids complexed with another type of chemical compound and include, for example, lipoproteins, phospholipids and glycolipids. Nonglycerides include, for example, sphingolipds, steroids and waxes.
  • Because most ingesta contain lipids, it is believed that the methods and devices described herein for prolonging lipid residence time, delaying lipid passage and/or providing lipids would enhance the operating characteristics of a duodenal positioned flow reduction device, such as those described in the related applications. In other words, the methods and devices described herein not only slow the passage of food but may also detain or delay the passage of food. The delay or detention may allow for prolonged nutrient release and aid in achieving health objectives. Additionally or alternatively, the devices and methods described herein may also provide for active introduction of lipids into the duodenum.
  • Catch and hold food, some of which is lipid. By using flow reduction bulges along the spine of the device pictured in FIG. 1, ingesta can be caught and held temporarily. The mesh bulges may have a more open structure on the end from which nutrients arrive from the stomach and smaller openings on the end from which nutrients depart as one way to hold nutrients longer. Alternatively, the spheres could themselves become ‘buckets’ in which food is captured and retained. The bucket may be provided by having a solid bottom portion so that chyme entering remains in the bottom of the bucket until pushed out by peristaltic action or my movement of additional chyme to displace it.
  • The flow restriction devices may be any of a wide variety of shapes and dimensions as described in the incorporated patent applications. The adjustment of the flow characteristics of ingesta or chyme: (a) around the outside of a flow reduction element, (b) through a wall of a flow or portion of a flow reduction element and (c) retained within a flow reduction element may be accomplished in a number of ways. One way to adjust the flow characteristics within a flow regulated duodenum (i.e., a duodenum having a flow reduction device implanted within it) is through the porosity or flow characteristics of the flow reduction elements.
  • FIG. 1 illustrates a perspective view of a device 100 having a spine 105, a proximal end 110, a distal end 115, atraumatic features 120 on both the proximal and distal ends. A series of five flow reduction elements 130 are shown in position along the spine 105. There may be one or more features 135 on the spine to prevent unwanted proximal or distal movement of the flow reduction elements 130 along the spine 105. The flow reduction elements 130 are shown in a deployed configuration as they would be in use within the duodenum. In the most basic form, one or more of the flow reduction elements may be formed from a material or materials with porosity characteristics that adjust the flow characteristics of chyme or ingesta flow relative to the material and the flow reduction element.
  • As shown in FIG. 1, the device 100 is orientated as it would be implanted with the proximal end 110 in the stomach and the distal end 115 in the duodenum near the ligament of Trietz. Chyme/ingesta flow is from the proximal end 110 to the distal end 115 in FIG. 1. The more porous portion of the flow reduction element 140 will interact with the chyme first. Because of the porosity of this part of the flow reduction element, chyme will flow into the interior portion of the flow reduction element as well as around the flow reduction element. As peristaltic action in the duodenum continues to move the chyme, the portion inside of the flow reduction element is urged distally towards the portion of the flow reduction device that is less porous 150. Some of the chyme entering the flow reduction element portion 150 will be retained within the flow reduction element for some period of time based upon a number of factors such as how much the person has eaten and the porosity of this portion of the flow reduction element among others. As a result of the variable porosity of the structure of the flow reduction element, chyme enters but then is delayed in leaving the flow reduction element interior. It is believed that increasing the residence time of chyme within a flow reduction element will increase the time of interaction of the nutrients in that trapped portion and/or provide for an extended release of the lipids in the trapped portion of chyme. The retained food could be nutrient rich or lipid rich so that the prolonged exposure produces a sense of satiety and/or the inhibition of liver glucose production in the individual. One such mechanism that may be achieved or fostered by the embodiments described herein is described in “Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production” by Penny Y. T. Wang et al (Nature, Vol. 452: 24 Apr. 2008 doi:10.1038/nature06852).
  • The flow characteristics of the flow reduction element may be adjusted in a number of ways. FIG. 2 is an enlarged view of a flow reduction element 130 in FIG. 1. The flow reduction element is divided roughly in half with an upper portion 140 (the part to first contact with the flow of chyme) having a porosity that allows flow through it and into the interior of the flow reduction element. The bottom portion 150 of the flow reduction element is less porous or allows less flow of chyme from the interior of the flow reduction element. The variable porosity or flow characteristics of the flow reduction elements may be adjusted by selecting material with different sizes (FIG. 2A), shapes, construction, and/or filaments with different characteristics to enhance or diminish flow as needed for the upper or lower portions. The flow characteristics of a flow reduction element may be obtained by overlapping (i.e., joined or crossed without joining) filaments to form cells that will, to the desired degree, permit or impede chyme passage. Alternatively or additionally, the flow reduction element could be formed from a solid or semi-permeable sheet 160 with holes 161 formed in it as shown in FIG. 2B. The size, shape, pattern and distribution of the openings may be used to adjust the amount of relative flow through a flow reduction element.
  • The flow reduction element adjustment may also be accomplished by adjusting the relative amounts of the flow reduction element used for allowing flow (more porous 140) or preventing flow (less porous 150). FIG. 3 illustrates a flow reduction element embodiment where more of the flow reduction device is utilized for allowing flow than for preventing flow. In contrast, FIG. 4 illustrates a flow reduction element embodiment where more of the flow reduction device is utilized for preventing flow than for allowing flow.
  • The foregoing are merely examples. More than one flow allowing or more than one flow preventing zone or portion may be used in a flow reduction element. While the relative distribution of the flow zones has been generally perpendicular to the spine or flow within the duodenum, other orientations relative to the spine or the duodenum are possible depending upon the desired flow profile. Moreover, a device may have flow reduction elements having one or more flow adjustment zones, or no flow adjustment zones. The type of flow reduction elements and the flow characteristics of those flow reduction elements may be mixed within a flow reduction device depending upon the desired flow characteristics desired.
  • Other flow reduction element properties such as the shape and size of a reduction element, the relative size between reduction elements, the alignment or orientation of a reduction element to the central shaft or spine and other properties are further described in the incorporated applications and may also be adjusted to accomplish the nutrient delivery aspects described herein.
  • Alternatively, the flow reduction elements could also be configured to capture and hold a lipid ‘pill’. For instance, to maintain a certain lipid level in the spheres, the patient could periodically swallow a lipid ‘pill’ or other form that engages the device and remains in place. The nutrient could also take the form of an extended release compound that releases an amount of the nutrient over time. The nutrient could also be mixed with another compound that is released when the patient consumes a releasing agent, such as before a meal or at a time of day prone to hunger pangs or higher than desired blood glucose levels. The releasing agent mixes with the nutrient compound mixture causing the release of nutrients, such as lipids, to aid in regulation of hunger and/or glucose.
  • In another aspect, the flow reduction device could be coated with, manufactured with or contain nutrients such as lipids or lipid-philic materials. For example, the flow reduction elements could be one or more bulges manufactured using lipid leaching materials; or the bulges could be manufactured with lipid-philic materials or a sponge like membrane inside the bulges or otherwise connected to the device backbone, that would absorb and distribute temporally lipids from passing ingesta to increase hormonal regulation.
  • In another aspect, the flow reduction elements positioned along the device backbone could be coated with, manufactured from or contain lipid-philic materials. For example, one or more of the flow reduction elements of the intraduodenal device could be manufactured from a lipid absorbing or adsorbing material. A flow reduction element manufactured in this way will attract and collect lipids from passing ingesta and hold the lipids for a period of time. The length of time that the lipids will remain attached to the flow reduction element will vary based on a number of factors. For example, the flow reduction element may exude the lipids as peristalsis continues to squeeze the device. The prolonged presence of and/or sustained release of lipids within the duodenum is believed to benefit and in some cases to increase hormonal regulation. It is to be appreciated that embodiments of the present invention provide prolonged presence of and/or sustained release of lipids within the duodenum through the use of one or more of: making flow reduction elements and/or other components of the flow reduction device (i.e., any of the components of FIG. 1 for example) at least partially or even completely from one or more lipid-philic materials; coating flow reduction elements and/or other components of the flow reduction device entirely or at least partially form lipid-philic materials; and/or placing within a flow reduction element, or attaching to a component of the flow reduction device an additional element or component formed from or at least partially coated with a lipid-philic material.
  • The spine could be configured as a central tube with plural inlet/outlet ports in communication with a flow reduction element and/or the outside of the tube as described in the incorporated applications. Additionally or alternatively, a portion of the device itself, i.e.: the backbone or spine, could be hollow such that it could be filled with lipids that would leach out or otherwise be delivered to the duodenum. A nutrient reservoir may be implanted within the patient, within the flow reduction device or separately injected into the device during implantation, after insertion or periodically while the patient has the device inserted in his duodenum.
  • Additionally or alternatively, the lipid equipped hormonal regulatory device could be configured to release lipids on demand using an internal or external controller or device as described in U.S. patent application Ser. No. 11/807,107, filed May 25, 2007, entitled “METHODS AND DEVICES TO CURB APPETITE AND/OR REDUCE FOOD INTAKE,” now Publication No. 2007-0293885.

Claims (19)

    What is claimed is:
  1. 1. A device configured to adjust the passage of ingesta through the duodenum of a mammal, comprising:
    a spine having a proximal end and a distal end, the spine having a length such that when the proximal end is in a stomach of the mammal, the distal end is in a duodenum of the mammal; and
    a flow reduction element positioned along the spine;
    wherein at least one portion of the device comprises a material configured to attract a component of the ingesta.
  2. 2. The device of claim 1, wherein the material is a lipid-philic material.
  3. 3. The device of claim 1, wherein the at least one portion is the flow reduction element.
  4. 4. The device of claim 3, wherein there are a plurality of flow reduction elements, and wherein each of the flow reduction elements comprises the material.
  5. 5. The device of claim 1, wherein the flow reduction element is configured to expand when used in the duodenum.
  6. 6. The device of claim 5, wherein the flow reduction element is configured to self-expand.
  7. 7. The device of claim 1, wherein the at least one portion is the spine.
  8. 8. The device of claim 1, wherein the material is a coating on the spine or the flow reduction element.
  9. 9. The device of claim 1, wherein the material forms the spine or the flow reduction element.
  10. 10. A method for adjusting the passage of ingesta through the duodenum of a mammal, comprising:
    placing a device in the mammal, the device comprising a spine having a proximal end and a distal end such that the proximal end is in a stomach of the mammal and the distal end is in the duodenum;
    expanding a flow reduction element positioned along the spine in the duodenum; and
    attracting a component from the ingesta to at least one portion of the device so as to hold the component for a period of time.
  11. 11. The method of claim 10, wherein the at least one portion is formed from or coated with a material configured to attract the component.
  12. 12. The method of claim 11, wherein the material is a lipid-philic material.
  13. 13. The method of claim 10, wherein the component comprises a lipid.
  14. 14. The method of claim 10, further comprising releasing the component from the device after the period of time.
  15. 15. The method of claim 14, wherein the releasing step occurs as peristalsis squeezes the at least one portion of the device.
  16. 16. The method of claim 10, wherein expanding the flow reduction element comprises allowing the flow reduction element to self-expand.
  17. 17. The method of claim 10, wherein there are a plurality of flow reduction elements, and wherein the expanding step comprises expanding each of the plurality of flow reduction elements.
  18. 18. The method of claim 10, wherein the at least one portion is the flow reduction element.
  19. 19. The method of claim 10, wherein the at least one portion is the spine.
US15384130 2004-02-26 2016-12-19 Methods and devices for delivering or delaying lipids within a duodenum Abandoned US20170156908A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US10999410 US7931693B2 (en) 2004-02-26 2004-11-30 Method and apparatus for reducing obesity
US11300283 US8147561B2 (en) 2004-02-26 2005-12-15 Methods and devices to curb appetite and/or reduce food intake
US11807107 US8585771B2 (en) 2004-02-26 2007-05-25 Methods and devices to curb appetite and/or to reduce food intake
US95007107 true 2007-07-16 2007-07-16
US7757908 true 2008-07-02 2008-07-02
PCT/US2008/070226 WO2009012335A1 (en) 2007-07-16 2008-07-16 A conformationally-stabilized intraluminal device for medical applications
PCT/US2009/049586 WO2010003097A3 (en) 2008-07-02 2009-07-02 Methods and devices for delivering or delaying lipids within a duodenum
US99918011 true 2011-01-31 2011-01-31
US13769097 US9072861B2 (en) 2004-11-30 2013-02-15 Methods and devices for delivering or delaying lipids within a duodenum
US14793454 US20150305906A1 (en) 2004-11-30 2015-07-07 Methods and devices for delivering or delaying lipids within a duodenum
US15384130 US20170156908A1 (en) 2004-11-30 2016-12-19 Methods and devices for delivering or delaying lipids within a duodenum

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US15384130 US20170156908A1 (en) 2004-11-30 2016-12-19 Methods and devices for delivering or delaying lipids within a duodenum

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US14793454 Continuation US20150305906A1 (en) 2004-02-26 2015-07-07 Methods and devices for delivering or delaying lipids within a duodenum

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US20170156908A1 true true US20170156908A1 (en) 2017-06-08

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US12999180 Abandoned US20110137227A1 (en) 2007-07-16 2009-07-02 Methods and devices for delivering or delaying lipids within a duodenum
US13769097 Active 2028-11-04 US9072861B2 (en) 2004-02-26 2013-02-15 Methods and devices for delivering or delaying lipids within a duodenum
US14793454 Abandoned US20150305906A1 (en) 2004-02-26 2015-07-07 Methods and devices for delivering or delaying lipids within a duodenum
US15384130 Abandoned US20170156908A1 (en) 2004-02-26 2016-12-19 Methods and devices for delivering or delaying lipids within a duodenum

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US12999180 Abandoned US20110137227A1 (en) 2007-07-16 2009-07-02 Methods and devices for delivering or delaying lipids within a duodenum
US13769097 Active 2028-11-04 US9072861B2 (en) 2004-02-26 2013-02-15 Methods and devices for delivering or delaying lipids within a duodenum
US14793454 Abandoned US20150305906A1 (en) 2004-02-26 2015-07-07 Methods and devices for delivering or delaying lipids within a duodenum

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US9060835B2 (en) * 2006-05-26 2015-06-23 Endosphere, Inc. Conformationally-stabilized intraluminal device for medical applications
US8147561B2 (en) 2004-02-26 2012-04-03 Endosphere, Inc. Methods and devices to curb appetite and/or reduce food intake
US8585771B2 (en) * 2004-02-26 2013-11-19 Endosphere, Inc. Methods and devices to curb appetite and/or to reduce food intake
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US20110137227A1 (en) 2011-06-09 application

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