US20170071988A1 - Oral dosage form - Google Patents

Oral dosage form Download PDF

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Publication number
US20170071988A1
US20170071988A1 US15/261,042 US201615261042A US2017071988A1 US 20170071988 A1 US20170071988 A1 US 20170071988A1 US 201615261042 A US201615261042 A US 201615261042A US 2017071988 A1 US2017071988 A1 US 2017071988A1
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Prior art keywords
mucoadhesive
tablet
active
mucosa
metal
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Abandoned
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US15/261,042
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Inventor
Rolf Daniels
Anja Hoffmann
Marcus Rudolf Götz
Jörg Thilo Fischer
Kerstin Holmgren
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Symrise AG
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Symrise AG
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Publication of US20170071988A1 publication Critical patent/US20170071988A1/en
Assigned to SYMRISE AG reassignment SYMRISE AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GOTZ, MARCUS RUDOLF, HOLMGREN, KERSTIN, DANIELS, ROLF, HOFFMANN, ANJA, FISCHER, JORG THILO
Priority to US16/574,402 priority Critical patent/US11033589B2/en
Abandoned legal-status Critical Current

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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N19/00—Investigating materials by mechanical methods
    • G01N19/04—Measuring adhesive force between materials, e.g. of sealing tape, of coating
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
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    • A61K2035/115—Probiotics
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Definitions

  • buccal/sublingual dosage forms are intended to be held in the mouth or under the tongue until the contained active substance have been completely released in the mouth.
  • buccal and/or sublingual dosage forms may be washed away in substantial proportion because of the continuous secretion of saliva in the oral cavity.
  • Suitable buccal and/or sublingual dosage forms must remain in contact with the oral mucosa for a time sufficient for interaction of the contained active substances with the oral mucosa.
  • a mucoadhesive agent to the dosage forms to extend the retention time in the mouth cavity and to increase the persistence of the active substance on the oral mucosa.
  • US 2014/0234212 A1 (MASSACHUSETTS INSTITUTE OF TECHNOLOGY) disclosed an oral delivery device comprising a mucoadhesive polymetric matrix, nanoparticles dispersing therein and an impermeable backing layer, wherein the active substances are loaded in the nanoparticles.
  • the oral delivery device should be placed onto the mucus layer and through the mucoadhesion adhere to the oral epithelium, where the nanoparticles penetrate in the mucosa and controlled release the loaded active substance.
  • the applied methods of the nanoparticles production are all carried out in a solution comprising active substance and the corresponding polymers.
  • US 2013/0337022 A1 (UNIVERSITY OF THE WITWATERSRAND) referred to a pharmaceutical dosage form comprising a mucoadhesive layer, a water-insoluble layer and an intermediate layer loading active substance, wherein the active substance are in the form of micro- and/or nanostructures and by directed dissolution, suspended or in an emulsion form incorporated into the intermediate layer.
  • the mucoadhesion of the dosage form was evaluated with Texture Analyser by measuring the tensile force required to separate the dosage membrane from a simulated gastric membrane.
  • US 2009/0110717 A1 concerned a transmucosal disk containing two compartments for administration of an active substance, preferably the active substance is in the inner compartment and the mucoadhesive agent is in the outer compartment.
  • the partial inner compartment and partial outer compartment adhered to the mucosal membrane to deliver the active substance through the buccal mucosa. After the desired effect of the active substance has been achieved, the disk could be easily peeled off.
  • Probiotics will be particularly introduced as one of the most commonly used active substances.
  • Probiotics are live non-toxic digestible microorganisms that can beneficially affect a host by providing: (1) normalization of flora (e.g., suppress PPMs, provide for intestinal mucosal integrity, regulation of bowel movement, IBS, etc.); (2) immunomodulation (e.g., strengthen immunity, alleviate food allergy symptoms, control of IBD, etc.); (3) metabolic effects (e.g., Production of vitamins to improve digestion, minimize lactose intolerance, lower cholesterol, promote bile acid deconjugates, etc.) and many other benefits to improve the host's intestinal microbial balance without causing any diseases.
  • flora e.g., suppress PPMs, provide for intestinal mucosal integrity, regulation of bowel movement, IBS, etc.
  • immunomodulation e.g., strengthen immunity, alleviate food allergy symptoms, control of IBD, etc.
  • metabolic effects e.g., Production of vitamins to improve
  • a probiotics should be delivered in a formulation that is stable when stored.
  • the colony number of bacteria and viability need to be reliable and they must survive the acid and bilious environment in the upper GI tract before they reach the small intestine and colon. Since the quality and content of probiotics have not been regulated, it is difficult to accurately assess their efficacy and safety.
  • Probiotic delivery systems can be categorized into conventional, pharmaceutical formulations, and non-conventional, mainly commercial food-based, products. Despite the great difference between the two systems, the adsorption sites of probiotic locate mostly in the GI tract.
  • an oral delivery system for delivering a probiotic formulation targeted to the ileum and proximal colon of a subject comprises: a core comprising a probiotic formulation, wherein the probiotic formulation is included in a biodegradable first capsule that is coated with a first enteric coating, and a second capsule sized to include the coated first capsule, wherein the second capsule releases the first capsule in the ileum and once released the first capsule is solubilized in the proximal colon with the release of the probiotic formulation contained therein.
  • the aim of the invention is to apply live probiotics culture direct in the oral cavity and keep enough amount of probiotics adhere to the oral mucosa to realize the effect of probiotics on the oral healthy.
  • the present invention provide mucoadhesive active granules and corresponding mucoadhesive dosage form processed from these granules, which can delivery active substance within the oral mucosal cavity, especially orodispersible tablets for delivering probiotic substance.
  • the said orodispersible tablets can totally disintegrate within short time and release active and attenuated probiotics, which can fix to the oral mucosa with the help of the components with mucoadhesion.
  • the solid active agent is preferably an anti-inflammatory, corticosteroid, anti-diarrhoeal, opioid, immunosuppressive, antibiotic, antiemetic, antifungal, antiviral, antimalarial, anti-TB drug, antiretroviral, antihypertensive, protein, peptide, chemotherapeutic, diagnostic agent, prebiotic, multivitamin, mineral, trace element, phytonutrient, protein, peptide or the like.
  • the solid active agents used in the present invention are beneficial microorganisms (probiotics) and their derivatives. It should be noted that this is the first time to realize the adhesion of probiotics to the oral mucosa with the help of mucoadhesive polymers.
  • FIG. 1 is a graph of stability data of mucoadhesive probiotic orodispersable tablets according to the present invention.
  • FIG. 2 schematically illustrates a system for testing the mucoadhesion of a formulation according to the present invention.
  • probiotics are understood as live microorganisms, which possess properties that are useful for the host. According to the FAO/WHO definition, they are “live microorganisms which at appropriate dosage give the host a health advantage”. Probiotics are usually ingested as a constituent of fermented foods, to which special live cultures have been added, e.g. yoghurt, soya yoghurt or other probiotic foods. Furthermore, tablets, capsules, powder and sachets are also available, which contain the microorganisms in freeze-dried form.
  • the preferable probiotics applied according to the present invention are listed as following:
  • probiotics derivatives such as heat-treated probiotics, fragments thereof for example epitopes can be formulated as the active agent in the sense of the present invention.
  • Mucoadhesive/Mucoadhesion is a property of a material that has the ability to adhere to mucosal membranes in the human body.
  • Mucoadhesive polymers preferably used in this invention include hydrophilic polymers and natural gums.
  • hydrophilic polymers examples include cellulosic polymers such as hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl methylcellulose, ethylhydroxyethyl cellulose, carboxymethyl cellulose and its salts and mixtures of two or more thereof; vinyl polymers such as polyvinyl acetate, polyvinyl alcohol, polyvinyl pyrrolidone; and acrylic acid polymers and copolymers such as polyacrylic acid and its salts, polycarbophil etc.
  • Natural gums are polysaccharides of natural origin.
  • Examples of some natural gums are carrageenan, konjac, sodium and calcium alginate, agarose, guar, pectin, tragacanth, acacia, arabic, dextran, gellan, xanthan, scleroglucan, hyaluronic acid, chitosan, fenugreek gum, locust bean gum etc. Combinations of the above mucoadhesive polymers may also be employed. Other mucoadhesive polymers or combinations of mucoadhesive polymers may also be used.
  • the most preferable mucoadhesive polymer in the present invention is selected from group comprising Carbopol 971P NF (polyacryl acid), Tylopur 615 (hypromellose, hydroxypropyl methylcellulose, HPMC), Metolose 65SH50 (hypromellose, hydroxypropyl methylcellulose, HPMC), and Chitosan.
  • the used ratio between a mucoadhesive polymer and a solid active agent is from about 10:1 to about 1:50, preferably from about 2:1 to about 1:20, more preferably from about 1:1 to about 1:10.
  • the used solid active agent can be firstly granulated, and then mixed with the mucoadhesive polymer.
  • the obtained granules of the solid active agent have a diameter from 50 to 1000 ⁇ m.
  • the mucoadhesive active composition of the present invention can be processed into granules with a diameter from 50 to 1000 ⁇ m.
  • Another object of the present invention is a mucoadhesive dosage form, especially an orodispersible tablet for delivering probiotic substance within the oral cavity.
  • An orodispersible tablet according to the present invention comprising
  • the orodispersible tablet of the invention disintegrates completely within 3 minutes regarding to European Pharmacopoeia measured by the described method “disintegration of tablets and capsules” (2.9.1). In the “Guidance for Industry Orally Disintegrating Tablets” from the FDA a disintegration time of less than 30 seconds is recommended. The released mucoadhesive probiotics granule can adhere to the buccal mucosa.
  • Orodispersible tablets are also called as orally disintegrating tablets, mouth-dissolving tablets, rapid-dissolving tablets, fast-disintegrating tablets, fast-melting tablets, and fast-dissolving tablets.
  • European Pharmacopoeia has used the term orodispersible tablets.
  • ODTs differ from traditional tablets in that they are designed to be dissolved in the oral cavity, for example on the tongue within short time period such as 3 minutes, rather than swallowed as whole.
  • the ODT serves as an alternative dosage form for delivering the active ingredients direct in the oral cavity, and influencing the active site locating in the buccal mucosa.
  • excipients may be defined as inactive constituents other than the physiologically and pharmacologically active constituents, edible cosmetics as well as foodstuffs, which are included in the manufacturing process or are contained in a finished pharmaceutical product dosage form.
  • excipients play an important part in the manufacturing process. They may also be important for keeping the active ingredients from being released too early in the assimilation process. Others help the drug to disintegrate into particles fast enough to release the active principle and still others protect the product's stability so it will be at maximum effectiveness at time of use.
  • some excipients are used to aid the identification of a drug product.
  • excipients are used simply to make the product taste and look better. This improves patient compliance, especially in children. Although technically “inactive” from a therapeutic sense, pharmaceutical excipients are critical and essential components of a modern drug product. In many products, excipients make up the bulk of the total dosage form.
  • the used excipients comprise at least one disintegrant.
  • a disintegrant is an excipient which is added to a tablet or a capsule to aid in the breakup of the compacted mass when it is put into a fluid environment. This is especially important for immediate release products where rapid release of active substance is required.
  • the oral dosage forms, especially orodispersible tablets of this invention include disintegrating agents (disintegrants) such as croscarmellose sodium, calcium carboxymethyl cellulose, crospovidone, hydroxypropylcellulose (low substituted), starch, sodium starch glycolate, alginic acid, calcium alginate, bentonite, cellulose, guar galactomannan and the like in amounts sufficient to achieve a desirable and efficient disintegration rate that optimizes release of the physiologically and pharmacologically active substance, edible cosmetics as well as foodstuffs, minimizes consumer's discomfort and inconvenience, or achieves a desired balance of release efficiency and reduced discomfort and/or inconvenience.
  • disintegrating agents such as croscarmellose sodium, calcium carboxymethyl cellulose, crospovid
  • crospovidone e.g. Kollidon CL-SF
  • crospovidone e.g. Kollidon CL-SF
  • the mucoadhesive active composition are present in an amount of from about 0.1 to about 80 wt. %, preferable from about 10 to about 40 wt. % based on the weight of the orodispersible tablet.
  • the disintegrants are present in an amount of from about 1 to about 15 wt. %, preferable from about 2 to about 5 wt. %, based on the weight of the orodispersible tablet.
  • obtained orodispersible tablet of the present invention complete disintegrate within about 3 minutes, preferably within about 30 seconds or less.
  • the mucoadhesive active composition comprises the solid active agent, especially the probiotics in the form of granules. It is obvious to the person skilled in the prior art, that granulation of the used components generally has negative influence on the disintegration time of the obtained orodispersible tablet. Hence the skilled person would avoid granulating the active agent with mucoadhesive polymers, in order to realize effective drug release of an orodispersible tablet.
  • the mucoadhesive active composition are processed into granules with a diameter from 50 to 1000 ⁇ m, preferably from 75 to 700 ⁇ m.
  • the European Pharmacopoeia defines “complete disintegration” as that state in which any residue of the unit, except fragments of insoluble coating or capsule shell, remaining on the screen of the test apparatus is a soft mass having no palpably firm core.
  • the disintegration time is a very important parameter for orodispersible tablets.
  • the disintegration time of the tablets was measured according to the method described in European Pharmacopoeia (Tablet disintegration (Ph.Eur. 2.9.1.)), which is a standard method. For determining the time for disintegration exactly, only one tablet was measured at a time. The temperature of the water was between 35° C. and 39° C. Maximum three tablets were tested per cycle, before changing the water in the beaker completely. A sample size of 6 tablets was measured from every batch. For lyophilisates and in accordance with Ph.Eur., disks were used to ballast the tablets, because they showed a tendency to float due to their low specific gravity.
  • the oral disintegrating tablet of the invention completely disperse in vitro within the time periods indicated, with a proviso to be made from a strict scientific standpoint, namely that, obviously, components of the tablets that are not soluble in the saliva will not dissolve but rather be dispersed and remain in the solid state.
  • the excipients used in the orodispersible tablet according to the present invention can further comprise fillers and lubricants.
  • Diluents or fillers are inert ingredients that can significantly affect the chemical and physical properties of the final tablet thus affecting the release profile. Moreover, a binder and filler is often necessary to prepare ODTs by direct compression to achieve sufficient hardness. Cellulose products are typical substances for this purpose. In particular microcrystalline cellulose can be beneficial as it also assists the fast disintegration of ODTs, involving swelling and a wicking effect. Further fillers that may be employed in the compression and oral dosage forms of this invention include water-soluble sugars such as lactose, glucose, sucrose, dextrose, isomalt and sugar alcohols such as lactose mannitol, sorbitol, xylitol, and erythritol.
  • water-soluble sugars such as lactose, glucose, sucrose, dextrose, isomalt
  • sugar alcohols such as lactose mannitol, sorbitol, xylitol, and erythritol.
  • water-soluble sugar and sugar alcohols may also be employed and combinations of water-soluble sugar and sugar alcohols may be used.
  • Other fillers that may be employed include, without limitation, calcium sulfate, calcium carbonate, dibasic calcium phosphate, stearic acid, starch, and microcrystalline cellulose.
  • the filler may be present in the orodispersible tablet of the present invention in an amount of from about 10 to about 90 wt % of the orodispersible tablet.
  • lubrication is essential in order to reduce the friction between the surfaces of manufacturing equipment and that of active solids, to prevent ingredients from clumping together as well as to ensure the continuation of an operation.
  • Pharmaceutical lubricants are the agents added to tablet formulations in a very small quantity (usually 0.25%-5.0%, w/w) to improve the processing properties of dosage forms.
  • Lubricants that may be employed in the compression and oral dosage forms of this invention include calcium and magnesium stearate, glycerol dibihenate, glycerol distearate, sodium stearyl fumarate, oleic acid, hydrogenated castor oil, sucrose fatty acid esters, stearic acid, adipic acid, fumaric acid, polyethyleneglycol, sodium benzoate, sodium dodecyl sulfate, poloxamers, and like.
  • the used lubricants is sodium stearyl fumarate (Pruv®).
  • the mucoadhesive dosage forms of the present invention may further comprise other optional ingredients as desired, including natural and/or artificial sweeteners such as aspartam, taste-masking agents and/or flavorants such as menthol, and colorants (e.g., red iron oxide dye).
  • natural and/or artificial sweeteners such as aspartam
  • taste-masking agents and/or flavorants such as menthol
  • colorants e.g., red iron oxide dye
  • Antioxidants, stabilizers, solubilizing agents, preservatives, colorants and other processing aids may also be employed as needed or desired to facilitate handling and/or compression into tablets or other oral dosage forms.
  • Another object of the present invention is a method of producing the mucoadhesive active granules of the present invention., more particularly a method of producing mucoadhesive active granules, comprising
  • the solid active agent used in the method is preferably probiotics.
  • the probiotic substance are with a diameter ⁇ 500 km, preferably ⁇ 400 ⁇ m, more preferably ⁇ 300 ⁇ m.
  • the preferable mucoadhesive polymer used in the method is selected from group comprising Carbopol 971P NF (Polyacryl acid), Tylopur 615 (hypromellose, hydroxypropyl methylcellulose, HPMC), Metolose 65SH50 (hypromellose, hydroxypropyl methylcellulose, HPMC), and Chitosan.
  • the used ratio between a mucoadhesive polymer and a solid active agent is from about 10:1 to about 1:50, preferably from about 2:1 to about 1:20, more preferably from about 1:1 to about 1:10.
  • Binders are agents which are used in pharmaceutical formulations (of solid oral dosage forms) to hold the active ingredient and inactive ingredients together.
  • binders are particularly used to bind the solid active agents, especially the probiotics, with the mucoadhesive polymer together.
  • binder agents are acacia gum, gelatin, polyvinylpyrrolidone and copovidone, polyvinyl alcohol, starch (paste and pre-gelatinized), sodium alginate and alginate derivatives, sorbitol, glucose and other sugars, tragacanth and soluble cellulose derivates like methylcellulose, hydroxypropylmethylcellulose, sodium carboxymethylcellulose and hydroxypropylcellulose, maltodextrin, poly methacrylate copolymers, e.g.
  • ammonio methacrylate copolymer methacrylic acid methyl methycrylate copolymer, basic butylated methacrylate copolymer, methacrylic acid ethyl acrylate copolymer, cellacefate, hypromellose acetate succinate, hypromellose phthalate, polyvinyl acetate phthalate, polyvinyl alcohol-polyethylene glycol copolymer, shellac.
  • mucoadhesive polymers can also be used as binder.
  • the preferably used binder in the present invention is anionic methacrylic acid ethyl acrylate copolymer (EUDRAGIT®L-Types).
  • the binders may be dissolved in a solvent, which must be volatile so that it can be removed by drying, and be non-toxic.
  • Typical solvent include water, ethanol and isopropanol either alone or in combination.
  • the binders is applied in amounts of 0.5-20 wt. %, preferably from 2-15 wt. % with respect to the solid active agents.
  • a solid active agent may be firstly mixed with a mucoadhesive polymer under dry condition, for example with the addition of desiccant bags, to obtain a dry blend.
  • the obtained dry blend is tempered to about from 15 to 25° C., preferably to 20° C. accompanied by the constant flow of nitrogen. Subsequently under stirring a binder solution is added into the dry blend.
  • the wetted granules may be sieved previous to the drying to remove big granules with a diameter >3500 ⁇ m, preferably >1000 ⁇ m, more preferably >700 ⁇ m.
  • drying of the wetted granules is carried out in the desiccator by flushing with compressed air.
  • the mucoadhesive active granules produced according to the method of the present invention is preferably with a water activity (a w ) ⁇ 0.1.
  • water activity is defined as the ratio of the vapour pressure of water in a material to the vapour pressure of pure water at the same temperature.
  • dried granules are sieved finally to remove big granules with a diameter >1000 ⁇ m, preferably >500 ⁇ m, more preferably >250 ⁇ m.
  • Another object of the present invention is a method of processing an orodispersible tablets, comprising
  • the mucoadhesive active granules is with a diameter between about 50 and about 1,000 ⁇ m, preferably between about 75 and about 700 ⁇ m, more preferably between about 100 and about 600 ⁇ m, and even more preferably about 500 ⁇ m.
  • the excipients are firstly sieved to obtain small particular excipients with diameter with a diameter ⁇ 500 ⁇ m, preferably ⁇ 400 ⁇ m, more preferably ⁇ 200 ⁇ m.
  • the orodispersible tablet produced through the method of the present invention is preferably in a weight of 20-1000 mg.
  • the orodispersible tablet produced through the method of the present invention is preferably with a diameter of 5-18 mm, more preferably with a diameter of 10 mm.
  • Another object of the present invention is to provide a system for testing a mucoadhesive formulation and quantify its mucoadhesion as illustrated in FIG. 2 , more particularly a system for testing the mucoadhesion of a formulation, comprising
  • the system further comprises a second container (C) including a top cover ( 8 ) with a pore ( 9 ) and a pump (D), which are via a pipe ( 10 ) passing through the pores ( 7 ) and ( 9 ) connected with the first container (B).
  • a second container (C) including a top cover ( 8 ) with a pore ( 9 ) and a pump (D), which are via a pipe ( 10 ) passing through the pores ( 7 ) and ( 9 ) connected with the first container (B).
  • a water bath (W) is arranged to keep the first container (B) and the second container (C) at a suitable temperature of about 37° C.
  • Another object of the present invention is a method of testing the mucoadhesion of a dosage form, wherein the method is carried on the system of the present invention, comprises the following steps:
  • the used mucosa is preferably a piece of porcine mucosa with a thickness of 1 to 5 mm and a diameter similar as that of the metal-cell (A).
  • the tested mucoadhesive formulation, or parts of it like one-fourth is usually with a weight of about 10-200 mg.
  • the used artificial saliva in the present invention is formulated to mimic natural saliva, but does not stimulate salivary gland activity.
  • the artificial saliva is pumped through the pipe ( 10 ) from the second container (C) to the mucoadhesive formulation (F) in the first container (B), wherein the pumping flow rate of the artificial saliva is from 0.05 ml/min to 1.0 ml/min, preferably from 0.1 ml/min to 0.5 ml/min and the pumping lasts 30 to 120 min, preferably 60 min.
  • CFU colony-forming unit
  • the mucoadhesion of a series of formulations can be determined, comprising, but not limited to, solid formulations, such as tablet, dragée, capsule, granule, powder and chewing gum, sticks, liquid formulations, such as solution, suspension, emulsion, syrup, spray, foam and semi-solid formulations, such as ointment, gel, paste.
  • solid formulations such as tablet, dragée, capsule, granule, powder and chewing gum
  • liquid formulations such as solution, suspension, emulsion, syrup, spray, foam and semi-solid formulations, such as ointment, gel, paste.
  • composition or product to be tested according to the invention may be selected form the group consisting of toothpaste, tooth gel, tooth powder, tooth cleaning liquid, tooth cleaning foam, mouth wash, mouth spray, dental floss, chewing gum and lozenges.
  • compositions or products may contain abrasive systems (abrasive and/or polishing components) such as silicates, calcium carbonate, calcium phosphate, aluminum oxide and/or hydroxyl apatite, surfactants such as e.g. sodium lauryl sulfate, sodium lauryl sarcosinate and/or cocamidopropyl betaine, humectants such as glycerol and/or sorbitol, thickening agents, e.g. carboxy methyl cellulose, poly ethylene glycols, carrageenans and/or Laponite®, sweeteners such as saccharine, aroma and taste correcting agents for unpleasant taste impressions, taste modifying substances (e.g.
  • inositol phosphate nucleotides, e.g. guanosine monophosphate, adenosine monophosphate or other substances, e.g. sodium glutamate or 2-phenoxy propionic acid
  • cooling agents such as menthol derivates (e.g.
  • active agents such as sodium fluoride, sodium monofluoro phosphate, tin difluoride, quarter-nary ammonium fluorides, zinc citrate, zinc sulfate, tin pyrophosphate, tin dichloride, mixtures of different pyrophosphate
  • Chewing gums or dental care chewing gums may comprise a chewing gum base comprising elastomers, e.g. polyvinyl acetate (PVA), polyethylene, (low or medium molecular) polyiso butane (PIB), polybutadiene, isobutene/isoprene copolymers, polyvinyl ethyl ether (PVE), polyvinyl butyl ether, copolymers of vinyl esters and vinyl ethers, styrene/butadiene copoly-mers (SBR) or vinyl elastomers, e.g.
  • PVA polyvinyl acetate
  • PIB low or medium molecular polyiso butane
  • PVE polyvinyl ethyl ether
  • SBR styrene/butadiene copoly-mers
  • vinyl elastomers e.g.
  • chewing gum bases may contain further ingredients, e.g. (mineral) filers, e.g. calcium carbonate, titanium dioxide, silicone dioxide, talcum, aluminum oxide, dicalcium phosphate, tricalcium phosphate, magnesium hydroxide and mixtures thereof, plasticisers (e.g.
  • lanolin stearic acid, sodium stearate, ethyl acetate, diacetin (glycerol diace-tate), triacetin (glycerol triacetate) and trietyhl citrate
  • emulsifiers e.g. phosphatides, such as lecithin and mono and diglycerides of fatty acids, e.g. glycerol monostearate
  • antioxidants es (e.g. paraffine waxes, candelilla waxes, carnauba waxes, microcrystalline waxes and polyethylene waxes), fats or fatty oils (e.g. hardened (hydrogenated) plant or animal fats) and mono, di or triglycerides.
  • the mucoadhesion of various formulations can be easily, stably and at low cost determined and the obtained results possess high accuracy and good repeatability.
  • Another object of the present invention is a use of the system of the present invention for testing the mucoadhesion of a formulation.
  • mucoadhesive orodispersible tablet comprising mucoadhesive (Metolose 65SH50) probiotic (Lactobacillus plantarum 299V) granules.
  • LP299V® Lactobacillus plantarum 299v
  • Metolose 65SH50 were added in a Turbula-Mixer and mixed at 30 r/min with the addition of desiccant bags for 5 min to obtain a dry homogeneous mixture, which was subsequently transferred into a Somakon Labmixer and tempered to 20° C. under flow of dry nitrogen.
  • LP299V® was mixed with Metolose 65SH50 for 10 min in Turbula mixer at 30 r/min using desiccant bag (pre-mix).
  • the mixture of Syloid® 244 FP and AL-1FP Silicas (1:1), flavour Optamint® Lemon-Lime and Avicel®PH 112 were separately sieved through a 315 ⁇ m sieve and mixed together with Pearlitol® 100 SD and Kollidon®CL-SF.
  • the pre-mixing with the bacteria was added and another 10 min mixed in Turbula mixer under the same conditions.
  • sieved Pruv® was added and 5 min mixed.
  • the final mixture was as in Example 1 pressed into a comparative mucoadhesive orodispersible tablet Cp1.
  • the characterization data of the tablet were concluded in Table 4.
  • mucoadhesive orodispersible tablet comprising mucoadhesive (Metolose 65SH50) probiotic (Lactobacillus paracasei 8700:2) granules.
  • Example 2 a mucoadhesive orodispersible tablet Ex2 was obtained and the characterization data of the tablet were concluded in Table 4.
  • mucoadhesive orodispersible tablet comprising mucoadhesive (Chitosan food grade) probiotic (Lactobacillus paracasei 8700:2) granules.
  • Example 3 a mucoadhesive orodispersible tablet Ex3 was obtained and the characterization data of the tablet were concluded in Table 4.
  • mucoadhesive orodispersible tablet comprising mucoadhesive (Carbopol 971P NF) probiotic (Lactobacillus plantarum HEAL9) by freeze-drying.
  • mucoadhesive Carbopol 971P NF
  • probiotic Lactobacillus plantarum HEAL9
  • orodispersible tablet comprising probiotic (Lactobacillus plantarum HEAL9) by freeze-drying.
  • the preparation steps was the same as that of Example 4 and the amount of each material is listed in Table 6, but Carbopol was exchanged by water.
  • the mucoadhesion of the obtained mucoadhesive orodispersible tablets was tested on the system as follows:
  • the artificial saliva in the first container (B) was firstly poured into the second sterilized glass beaker. Then 500 ml dilute agent (8.5 g/l sodium chloride, 1 g/l peptone) was used to wash the container (B) and the rest part of the metal-cell (A), and then also poured into the second sterilized glass beaker. By the addition of the dilute agent (8.5 g/l sodium chloride, 1 g/l peptone) the liquid in the glass beaker was added to 1000 g. The obtained solution B was magnetic stirred at 200 rpm for 5 min.
  • the used artificial saliva was prepared according to Matzker/Schreiber 1972 (without CaCl 2 ) and its composition was listed in the following Table 6.
  • the obtained solution A and B were respectively used to determine the number of viable bacteria adhesive to the mucosa and the number of viable bacteria washed off with the artificial saliva.
  • the CFU was calculated with the following formula:

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