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US20170049369A1 - Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System - Google Patents

Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System Download PDF

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Publication number
US20170049369A1
US20170049369A1 US15344500 US201615344500A US2017049369A1 US 20170049369 A1 US20170049369 A1 US 20170049369A1 US 15344500 US15344500 US 15344500 US 201615344500 A US201615344500 A US 201615344500A US 2017049369 A1 US2017049369 A1 US 2017049369A1
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Prior art keywords
sensor
unit
transmitter
signal
embodiment
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Abandoned
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US15344500
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Gary Alan Hayter
Kenneth J. Doniger
Erwin Satrya Budiman
Songbiao Zhang
John Charles Mazza
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Abbott Diabetes Care Inc
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Abbott Diabetes Care Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1495Calibrating or testing of in-vivo probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14503Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes electrical and mechanical details of in vitro measurements
    • G01N27/3271Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02Operational features
    • A61B2560/0223Operational features of calibration, e.g. protocols for calibrating sensors

Abstract

Method and apparatus for providing calibration of analyte sensor including applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured response is provided

Description

    RELATED APPLICATIONS
  • [0001]
    The present application is a continuation of U.S. patent application Ser. No. 15/209,743 filed Jul. 13, 2016, which is a continuation of U.S. patent application Ser. No. 13/766,673 filed Feb. 13, 2013, now U.S. Pat. No. 9,408,566, which is a continuation of U.S. patent application Ser. No. 12/624,377 filed Nov. 23, 2009, now U.S. Pat. No. 8,376,945, which is a continuation of U.S. patent application Ser. No. 11/463,582 filed Aug. 9, 2006, now U.S. Pat. No. 7,653,425, entitled “Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System”, the disclosures of each of which are incorporated herein by reference for all purposes.
  • BACKGROUND
  • [0002]
    Analyte, e.g., glucose monitoring systems including continuous and discrete monitoring systems generally include a small, lightweight battery powered and microprocessor controlled system which is configured to detect signals proportional to the corresponding measured glucose levels using an electrometer, and RF signals to transmit the collected data. One aspect of certain analyte monitoring systems include a transcutaneous or subcutaneous analyte sensor configuration which is, for example, partially mounted on the skin of a subject whose analyte level is to be monitored. The sensor cell may use a two or three-electrode (work, reference and counter electrodes) configuration driven by a controlled potential (potentiostat) analog circuit connected through a contact system.
  • [0003]
    To obtain accurate data from the analyte sensor, calibration is necessary. Typically, blood glucose measurements are periodically obtained using, for example, a blood glucose meter, and the measured blood glucose values are used to calibrate the sensors. Indeed, the patient must calibrate each new analyte sensor using for example, capillary blood glucose measurements. This may be inconvenient for the patient.
  • [0004]
    In view of the foregoing, it would be desirable to have a method and system for calibrating analyte sensors of an analyte monitoring system that does not inconveniently require periodic blood glucose measurements for sensor calibration.
  • SUMMARY OF THE INVENTION
  • [0005]
    In view of the foregoing, in accordance with the various embodiments of the present invention, there is provided a method and system for providing substantially automatic and substantially real time calibration of analyte sensors for use in an analyte monitoring system.
  • [0006]
    These and other objects, features and advantages of the present invention will become more fully apparent from the following detailed description of the embodiments, the appended claims and the accompanying drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0007]
    FIG. 1 illustrates a block diagram of a data monitoring and management system for practicing one embodiment of the present invention;
  • [0008]
    FIG. 2 is a block diagram of the transmitter unit of the data monitoring and management system shown in FIG. 1 in accordance with one embodiment of the present invention;
  • [0009]
    FIG. 3 is a block diagram of the receiver/monitor unit of the data monitoring and management system shown in FIG. 1 in accordance with one embodiment of the present invention;
  • [0010]
    FIG. 4 is a flowchart illustrating the analyte sensor sensitivity estimation procedure in accordance with one embodiment of the present invention;
  • [0011]
    FIG. 5 is a flowchart illustrating the analyte sensor parameter estimation procedure in accordance with one embodiment of the present invention;
  • [0012]
    FIG. 6 is a flowchart illustrating an analyte sensor sensitivity estimation procedure in accordance with another embodiment of the present invention;
  • [0013]
    FIG. 7A illustrates the transmission of the control signal from the transmitter processor in accordance with one embodiment of the present invention;
  • [0014]
    FIG. 7B illustrates the measured response to the control signal from the transmitter processor shown in FIG. 7A in accordance with one embodiment of the present invention;
  • [0015]
    FIG. 8 is a tabular illustration of a lookup table for sensor sensitivity for use with the calibration procedure in accordance with one embodiment of the present invention; and
  • [0016]
    FIG. 9 is a flowchart illustrating the analyte sensor sensitivity estimation procedure in accordance with another embodiment of the present invention.
  • DETAILED DESCRIPTION
  • [0017]
    As described in detail below, in accordance with the various embodiments of the present invention, there is provided a method and system for determining sensor sensitivity of an analyte sensor which may be used to calibrate the analyte sensor in the analyte monitoring system. In particular, within the scope of the present invention, there is provided method and system for automatically calibrating subcutaneous or transcutaneously positioned analyte sensors such that the frequency of capillary blood glucose measurement for calibration of the sensors may be minimized.
  • [0018]
    More specifically, FIG. 1 illustrates a data monitoring and management system such as, for example, analyte (e.g., glucose) monitoring system 100 in accordance with one embodiment of the present invention. The subject invention is further described primarily with respect to a glucose monitoring system for convenience and such description is in no way intended to limit the scope of the invention. It is to be understood that the analyte monitoring system may be configured to monitor a variety of analytes, e.g., lactate, and the like.
  • [0019]
    Analytes that may be monitored include, for example, acetyl choline, amylase, bilirubin, cholesterol, chorionic gonadotropin, creatine kinase (e.g., CK-MB), creatine, DNA, fructosamine, glucose, glutamine, growth hormones, hormones, ketones, lactate, peroxide, prostate-specific antigen, prothrombin, RNA, thyroid stimulating hormone, and troponin. The concentration of drugs, such as, for example, antibiotics (e.g., gentamicin, vancomycin, and the like), digitoxin, digoxin, drugs of abuse, theophylline, and warfarin, may also be monitored.
  • [0020]
    The analyte monitoring system 100 includes a sensor 101, a transmitter unit 102 coupled to the sensor 101, and a receiver unit 104 which is configured to communicate with the transmitter unit 102 via a communication link 103. The receiver unit 104 may be further configured to transmit data to a data processing terminal 105 for evaluating the data received by the receiver unit 104. Moreover, the data processing terminal in one embodiment may be configured to receive data directly from the transmitter unit 102 via a communication link 106 which may optionally be configured for bi-directional communication.
  • [0021]
    Only one sensor 101, transmitter unit 102, receiver unit 104, communication link 103, and data processing terminal 105 are shown in the embodiment of the analyte monitoring system 100 illustrated in FIG. 1. However, it will be appreciated by one of ordinary skill in the art that the analyte monitoring system 100 may include one or more sensor 101, transmitter unit 102, receiver unit 104, communication link 103, and data processing terminal 105. Moreover, within the scope of the present invention, the analyte monitoring system 100 may be a continuous monitoring system, or semi-continuous, or a discrete monitoring system. In a multi-component environment, each device is configured to be uniquely identified by each of the other devices in the system so that communication conflict is readily resolved between the various components within the analyte monitoring system 100.
  • [0022]
    In one embodiment of the present invention, the sensor 101 is physically positioned in or on the body of a user whose analyte level is being monitored. The sensor 101 may be configured to continuously sample the analyte level of the user and convert the sampled analyte level into a corresponding data signal for transmission by the transmitter unit 102. In one embodiment, the transmitter unit 102 is mounted on the sensor 101 so that both devices are positioned on the user's body. The transmitter unit 102 performs data processing such as filtering and encoding on data signals, each of which corresponds to a sampled analyte level of the user, for transmission to the receiver unit 104 via the communication link 103.
  • [0023]
    In one embodiment, the analyte monitoring system 100 is configured as a one-way RF communication path from the transmitter unit 102 to the receiver unit 104. In such embodiment, the transmitter unit 102 transmits the sampled data signals received from the sensor 101 without acknowledgement from the receiver unit 104 that the transmitted sampled data signals have been received. For example, the transmitter unit 102 may be configured to transmit the encoded sampled data signals at a fixed rate (e.g., at one minute intervals) after the completion of the initial power on procedure. Likewise, the receiver unit 104 may be configured to detect such transmitted encoded sampled data signals at predetermined time intervals. Alternatively, the analyte monitoring system 100 may be configured with a bi-directional RF (or otherwise) communication between the transmitter unit 102 and the receiver unit 104.
  • [0024]
    Additionally, in one aspect, the receiver unit 104 may include two sections. The first section is an analog interface section that is configured to communicate with the transmitter unit 102 via the communication link 103. In one embodiment, the analog interface section may include an RF receiver and an antenna for receiving and amplifying the data signals from the transmitter unit 102, which are thereafter, demodulated with a local oscillator and filtered through a band-pass filter. The second section of the receiver unit 104 is a data processing section which is configured to process the data signals received from the transmitter unit 102 such as by performing data decoding, error detection and correction, data clock generation, and data bit recovery.
  • [0025]
    In operation, upon completing the power-on procedure, the receiver unit 104 is configured to detect the presence of the transmitter unit 102 within its range based on, for example, the strength of the detected data signals received from the transmitter unit 102 or a predetermined transmitter identification information. Upon successful synchronization with the corresponding transmitter unit 102, the receiver unit 104 is configured to begin receiving from the transmitter unit 102 data signals corresponding to the user's detected analyte level. More specifically, the receiver unit 104 in one embodiment is configured to perform synchronized time hopping with the corresponding synchronized transmitter unit 102 via the communication link 103 to obtain the user's detected analyte level.
  • [0026]
    Referring again to FIG. 1, the data processing terminal 105 may include a personal computer, a portable computer such as a laptop or a handheld device (e.g., personal digital assistants (PDAs)), and the like, each of which may be configured for data communication with the receiver via a wired or a wireless connection. Additionally, the data processing terminal 105 may further be connected to a data network (not shown) for storing, retrieving and updating data corresponding to the detected analyte level of the user.
  • [0027]
    Within the scope of the present invention, the data processing terminal 105 may include an infusion device such as an insulin infusion pump or the like, which may be configured to administer insulin to patients, and which may be configured to communicate with the receiver unit 104 for receiving, among others, the measured analyte level. Alternatively, the receiver unit 104 may be configured to integrate an infusion device therein so that the receiver unit 104 is configured to administer insulin therapy to patients, for example, for administering and modifying basal profiles, as well as for determining appropriate boluses for administration based on, among others, the detected analyte levels received from the transmitter unit 102.
  • [0028]
    Additionally, the transmitter unit 102, the receiver unit 104 and the data processing terminal 105 may each be configured for bi-directional wireless communication such that each of the transmitter unit 102, the receiver unit 104 and the data processing terminal 105 may be configured to communicate (that is, transmit data to and receive data from) with each other via the wireless communication link 103. More specifically, the data processing terminal 105 may in one embodiment be configured to receive data directly from the transmitter unit 102 via the communication link 106, where the communication link 106, as described above, may be configured for bi-directional communication.
  • [0029]
    In this embodiment, the data processing terminal 105 which may include an insulin pump, may be configured to receive the analyte signals from the transmitter unit 102, and thus, incorporate the functions of the receiver unit 104 including data processing for managing the patient's insulin therapy and analyte monitoring. In one embodiment, the communication link 103 may include one or more of an RF communication protocol, an infrared communication protocol, a Bluetooth® enabled communication protocol, an 802.11x wireless communication protocol, or an equivalent wireless communication protocol which would allow secure, wireless communication of several units (for example, per HIPAA requirements) while avoiding potential data collision and interference.
  • [0030]
    FIG. 2 is a block diagram of the transmitter unit of the data monitoring and detection system shown in FIG. 1 in accordance with one embodiment of the present invention. Referring to the Figure, the transmitter unit 102 in one embodiment includes an analog interface 201 configured to communicate with the sensor 101 (FIG. 1), a user input 202, and a temperature detection section 203, each of which is operatively coupled to a transmitter processor 204 such as a central processing unit (CPU). There are provided four contacts (not shown), three of which are electrodes—work electrode, guard contact, reference electrode, and counter electrode, each operatively coupled to the analog interface 201 of the transmitter unit 102 for connection to the sensor 101 (FIG. 1). In one embodiment, each of the work electrode, guard contact, reference electrode, and counter electrode may be made using a conductive material that is either printed or etched, for example, such as carbon which may be printed, or metal foil (e.g., gold) which may be etched.
  • [0031]
    Further shown in FIG. 2 are a transmitter serial communication section 205 and an RF transmitter 206, each of which is also operatively coupled to the transmitter processor 204. Moreover, a power supply 207 such as a battery is also provided in the transmitter unit 102 to provide the necessary power for the transmitter unit 102. Additionally, as can be seen from the Figure, clock 208 is provided to, among others, supply real time information to the transmitter processor 204.
  • [0032]
    In one embodiment, a unidirectional input path is established from the sensor 101 (FIG. 1) and/or manufacturing and testing equipment to the analog interface 201 of the transmitter unit 102, while a unidirectional output is established from the output of the RF transmitter 206 of the transmitter unit 102 for transmission to the receiver unit 104. In this manner, a data path is shown in FIG. 2 between the aforementioned unidirectional input and output via a dedicated link 209 from the analog interface 201 to serial communication section 205, thereafter to the processor 204, and then to the RF transmitter 206. As such, in one embodiment, via the data path described above, the transmitter unit 102 is configured to transmit to the receiver unit 104 (FIG. 1), via the communication link 103 (FIG. 1), processed and encoded data signals received from the sensor 101 (FIG. 1). Additionally, the unidirectional communication data path between the analog interface 201 and the RF transmitter 206 discussed above allows for the configuration of the transmitter unit 102 for operation upon completion of the manufacturing process as well as for direct communication for diagnostic and testing purposes.
  • [0033]
    As discussed above, the transmitter processor 204 is configured to transmit control signals to the various sections of the transmitter unit 102 during the operation of the transmitter unit 102. In one embodiment, the transmitter processor 204 also includes a memory (not shown) for storing data such as the identification information for the transmitter unit 102, as well as the data signals received from the sensor 101. The stored information may be retrieved and processed for transmission to the receiver unit 104 under the control of the transmitter processor 204. Furthermore, the power supply 207 may include a commercially available battery.
  • [0034]
    The transmitter unit 102 is also configured such that the power supply section 207 is capable of providing power to the transmitter for a minimum of about three months of continuous operation after having been stored for about eighteen months in a low-power (non-operating) mode. In one embodiment, this may be achieved by the transmitter processor 204 operating in low power modes in the non-operating state, for example, drawing no more than approximately 1 μA of current. Indeed, in one embodiment, the final step during the manufacturing process of the transmitter unit 102 may place the transmitter unit 102 in the lower power, non-operating state (i.e., post-manufacture sleep mode). In this manner, the shelf life of the transmitter unit 102 may be significantly improved.
  • [0035]
    Moreover, as shown in FIG. 2, while the power supply unit 207 is shown as coupled to the processor 204, and as such, the processor 204 is configured to provide control of the power supply unit 207, it should be noted that within the scope of the present invention, the power supply unit 207 is configured to provide the necessary power to each of the components of the transmitter unit 102 shown in FIG. 2.
  • [0036]
    Referring back to FIG. 2, the power supply section 207 of the transmitter unit 102 in one embodiment may include a rechargeable battery unit that may be recharged by a separate power supply recharging unit (for example, provided in the receiver unit 104) so that the transmitter unit 102 may be powered for a longer period of usage time. Moreover, in one embodiment, the transmitter unit 102 may be configured without a battery in the power supply section 207, in which case the transmitter unit 102 may be configured to receive power from an external power supply source (for example, a battery) as discussed in further detail below.
  • [0037]
    Referring yet again to FIG. 2, the temperature detection section 203 of the transmitter unit 102 is configured to monitor the temperature of the skin near the sensor insertion site. The temperature reading is used to adjust the analyte readings obtained from the analog interface 201. The RF transmitter 206 of the transmitter unit 102 may be configured for operation in the frequency band of 315 MHz to 322 MHz, for example, in the United States. Further, in one embodiment, the RF transmitter 206 is configured to modulate the carrier frequency by performing Frequency Shift Keying and Manchester encoding. In one embodiment, the data transmission rate is 19,200 symbols per second, with a minimum transmission range for communication with the receiver unit 104.
  • [0038]
    Additional detailed description of the continuous analyte monitoring system, its various components including the functional descriptions of the transmitter are provided in U.S. Pat. No. 6,175,752 issued Jan. 16, 2001 entitled “Analyte Monitoring Device and Methods of Use”, and in U.S. patent application Ser. No. 10/745,878 filed Dec. 26, 2003, now U.S. Pat. No. 7,811,231, entitled “Continuous Glucose Monitoring System and Methods of Use”, each assigned to the Assignee of the present application.
  • [0039]
    FIG. 3 is a block diagram of the receiver/monitor unit of the data monitoring and management system shown in FIG. 1 in accordance with one embodiment of the present invention. Referring to FIG. 3, the receiver unit 104 includes a blood glucose test strip interface 301, an RF receiver 302, an input 303, a temperature detection section 304, and a clock 305, each of which is operatively coupled to a receiver processor 307. As can be further seen from the Figure, the receiver unit 104 also includes a power supply 306 operatively coupled to a power conversion and monitoring section 308. Further, the power conversion and monitoring section 308 is also coupled to the receiver processor 307. Moreover, also shown are a receiver serial communication section 309, and an output 310, each operatively coupled to the receiver processor 307.
  • [0040]
    In one embodiment, the test strip interface 301 includes a glucose level testing portion to receive a manual insertion of a glucose test strip, and thereby determine and display the glucose level of the test strip on the output 310 of the receiver unit 104. This manual testing of glucose can be used to calibrate sensor 101. The RF receiver 302 is configured to communicate, via the communication link 103 (FIG. 1) with the RF transmitter 206 of the transmitter unit 102, to receive encoded data signals from the transmitter unit 102 for, among others, signal mixing, demodulation, and other data processing. The input 303 of the receiver unit 104 is configured to allow the user to enter information into the receiver unit 104 as needed. In one aspect, the input 303 may include one or more keys of a keypad, a touch-sensitive screen, or a voice-activated input command unit. The temperature detection section 304 is configured to provide temperature information of the receiver unit 104 to the receiver processor 307, while the clock 305 provides, among others, real time information to the receiver processor 307.
  • [0041]
    Each of the various components of the receiver unit 104 shown in FIG. 3 is powered by the power supply 306 which, in one embodiment, includes a battery. Furthermore, the power conversion and monitoring section 308 is configured to monitor the power usage by the various components in the receiver unit 104 for effective power management and to alert the user, for example, in the event of power usage which renders the receiver unit 104 in sub-optimal operating conditions. An example of such sub-optimal operating condition may include, for example, operating the vibration output mode (as discussed below) for a period of time thus substantially draining the power supply 306 while the processor 307 (thus, the receiver unit 104) is turned on. Moreover, the power conversion and monitoring section 308 may additionally be configured to include a reverse polarity protection circuit such as a field effect transistor (FET) configured as a battery activated switch.
  • [0042]
    The serial communication section 309 in the receiver unit 104 is configured to provide a bi-directional communication path from the testing and/or manufacturing equipment for, among others, initialization, testing, and configuration of the receiver unit 104. Serial communication section 104 can also be used to upload data to a computer, such as time-stamped blood glucose data. The communication link with an external device (not shown) can be made, for example, by cable, infrared (IR) or RF link. The output 310 of the receiver unit 104 is configured to provide, among others, a graphical user interface (GUI) such as a liquid crystal display (LCD) for displaying information. Additionally, the output 310 may also include an integrated speaker for outputting audible signals as well as to provide vibration output as commonly found in handheld electronic devices, such as mobile telephones presently available. In a further embodiment, the receiver unit 104 also includes an electro-luminescent lamp configured to provide backlighting to the output 310 for output visual display in dark ambient surroundings.
  • [0043]
    Referring back to FIG. 3, the receiver unit 104 in one embodiment may also include a storage section such as a programmable, non-volatile memory device as part of the processor 307, or provided separately in the receiver unit 104, operatively coupled to the processor 307. The processor 307 is further configured to perform Manchester decoding as well as error detection and correction upon the encoded data signals received from the transmitter unit 102 via the communication link 103.
  • [0044]
    Referring back to the Figures, as described in further detail below, in one embodiment of the present invention, the transmitter processor 204 may be configured to transmit a control signal to the analog interface 201 to determine the poise voltage between the work electrode and the reference electrode of the sensor 101, each of which are operatively coupled to the analog interface 201 of the transmitter unit 102.
  • [0045]
    More specifically, in one embodiment, a control processor component of the transmitter unit 102 processor 204 is configured to provide a perturbation control signal to the analog interface 201. The analog interface 201 is configured to translate the received perturbation control signal to a perturbation that affects the sensor response. For example, the control signal in one embodiment may be configured to control the voltage level that is applied to the sensor 101 between the work and reference electrodes (i.e., the poise voltage). In one embodiment, the analog interface 201 of the transmitter unit 102 is configured to translate the sensor response to the perturbation to a corresponding response signal that is acquired by the signal processing component of the processor 204 of the transmitter unit 102. The signal processing component of the processor 204 in the transmitter unit 102 in one embodiment may be configured to determine the desired sensor parameter estimation which is transmitted to the receiver unit 104. Alternatively, the signal processing component of the processor 204 in the transmitter unit 102 may be configured to preprocess the data, which are then transmitted to the receiver unit for sensor parameter estimation determination.
  • [0046]
    More specifically, FIG. 4 is a flowchart illustrating analyte sensor sensitivity estimation procedure in accordance with one embodiment of the present invention. Referring to FIG. 4, at step 410, the transmitter processor 204 (FIG. 2) in one embodiment is configured to provide a control signal to the analog interface 201 (for example a poise voltage control circuit) of the transmitter unit 102. In one aspect, the control signal provides a perturbation input to determine the poise voltage between the work electrode and the reference electrode of the sensor 101. In one aspect, the poise voltage may be in the range of approximately −600 mV and 600 mV, and the analog interface 201 may be configured to control the poise voltage and apply the poise voltage to the electrodes of the sensor 101.
  • [0047]
    One embodiment of the control signal perturbations is shown in FIG. 7A which illustrates the control signal from the transmitter processor 204 so as to provide a poise voltage waveform that is a square wave of 50% duty cycle with a one minute time period interval. In one embodiment, the poise voltage square wave amplitude may be switched from 40 mV to −600 mV from, for example, the normal operating poise voltage to a predetermined level such as −600 mV which effectively shuts down the current signal on the work electrode.
  • [0048]
    Referring back to FIG. 4, at step 420, the analog interface 201 in one embodiment is configured to determine a measured response to the received control signal, for example, a voltage signal which is substantially proportional to the current signal level on the work electrode of the sensor 101. An aspect of the measured response is illustrated in FIG. 7B. As shown, in one aspect, the current signal level is associated with the analyte level of the patient and may be modulated by the poise voltage perturbations driven by the control signal from the transmitter processor 204. Thereafter at step 430, the transmitter processor 204 may be optionally configured to synchronize the measured response from the analog interface 201 with the control signal. The transmitter processor 204 may be further configured to store the measured response and the associated control signal in a storage unit (not shown) such as a memory device.
  • [0049]
    Referring again to FIG. 4, the transmitter processor 204 in one embodiment is configured to determine the difference or variance in the measured response based on the control signal 440, and the sensor sensitivity may be determined based on the determined difference in measured response 450. That is, in one embodiment, the difference in measured response is compared to a look up table stored, for example, in the transmitter processor 204 memory unit which includes calculated measured response difference for the sensor based on characteristics of the sensor 101.
  • [0050]
    By way of an example, for a measured response difference of 47 analog to digital counts, the lookup table for sensor sensitivity (FIG. 8) indicates 34.5 pA/(mg/dL) for the sensor. Then, the determined sensor sensitivity may be applied to the work electrode current to determine the corresponding calibrated analyte value. That is, the calibrated analyte value may be determined by dividing the work electrode current signal by the sensor sensitivity.
  • [0051]
    FIG. 5 is a flowchart illustrating the analyte sensor parameter estimation procedure in accordance with one embodiment of the present invention. Referring to FIG. 5, at step 510, a perturbation control signal is applied to the sensor 101 (FIG. 1), and then the response to the perturbation control signal is measured at step 520. Based on the measured response to the perturbation control signal, at step 530, the sensor parameter(s) is estimated and at step 540, the analyte level is estimated based on the measured response to the perturbation control signal. In one embodiment, the procedure shown in FIG. 5 is repeated continuously.
  • [0052]
    In accordance with the various embodiments of the present invention, different estimates may be determined including, for example, estimation of sensor properties such as sensitivity and response time, the analyte level, and analyte level validity/accuracy. In one embodiment, there are several mechanisms that may be used to perturb the sensor 101 (FIG. 1), for example, the variable poise voltage. In a further aspect, the one or more of the perturbation control signals may include, for example, square waves. Also, in one aspect, the one or more physical sensor responses that are measured may include, for example, work electrode current variation due to poise voltage perturbation. In addition, signal processing may be used in one embodiment to estimate the sensor parameter or analyte level from the sensor response to the perturbation as described above.
  • [0053]
    FIG. 6 is a flowchart illustrating an analyte sensor sensitivity estimation procedure in accordance with another embodiment of the present invention. Referring to FIG. 6, a control signal is applied 610, for example, to the analog interface 201 of the transmitter unit 102 (FIG. 1). That is, in one embodiment, the processor 204 of the transmitter unit 102 may be configured to provide a control signal to a poise voltage control circuit (for example, incorporated in the processor 204 of the transmitter unit 102 as shown in FIG. 2, but which may, in one embodiment, be separately provided within the transmitter unit 102) of the transmitter unit 102.
  • [0054]
    In one aspect, the control signal may be configured to provide a perturbation input signal to determine the poise voltage between the work electrode and the reference electrode of the sensor 101. In one embodiment, the poise voltage may be in the range of approximately −600 mV and 600 mV, and the analog interface 201 may be configured to control the poise voltage and apply the poise voltage to the electrodes of the sensor 101.
  • [0055]
    As described in further detail below, an embodiment of the control signal perturbations is shown in FIG. 7A which illustrates the control signal from the processor 204 (FIG. 2) to provide a poise voltage waveform that is a square wave of 50% duty cycle with a one minute time period interval. Referring to FIG. 7A, in one embodiment, the poise voltage square wave amplitude may be switched from 40 mV to −600 mV from, for example, the normal operating poise voltage to a predetermined level such as −600 mV which effectively shuts down the current signal on the work electrode.
  • [0056]
    Referring back to FIG. 6, the analog interface 201 in one embodiment is configured to determine a measured response to the received control signal 620, for example, a voltage signal which is substantially proportional to the current signal level on the work electrode of the sensor 101 (FIG. 1). As discussed in further detail below, one embodiment of the measured response is shown in FIG. 7B. Referring to FIG. 7B, in one embodiment, the average signal level for half of the duty cycle is associated with the analyte level of the patient, but the transient within the half-duty cycle period, caused by the poise voltage perturbations driven by the control signal from the transmitter processor 204, is associated with the sensitivity parameter of the sensor 101. The transmitter processor 204 may be further configured to store the measured response and the associated control signal in a storage unit (not shown) such as a memory device.
  • [0057]
    Referring again to FIG. 6, the transmitter processor 204 in one embodiment is configured to determine the amplitude difference of the transient from the start of the half-duty cycle to the end (referred to sometimes as the “on” period) in the measured response 630, and the sensor sensitivity may be determined based on the determined difference in the response 640. That is, in one embodiment, the difference in measured response is compared to a predetermined sensor parameter such as sensor sensitivity that may be stored in a look up table, for example, in the transmitter processor 204 memory unit. In one aspect, the look up table may include a calculated measured response difference for the sensor 101 and corresponding sensor sensitivities based on characteristics of the sensor 101.
  • [0058]
    In one embodiment, the transmitter may be configured to determine this sensitivity value once per minute, and to transmit the sensitivity value it to the receiver unit 104 (FIG. 1) in addition to data or signal corresponding to the work current signal level, determined at the end of the “on” period, and skin temperature.
  • [0059]
    In one embodiment, the receiver unit 104 (FIG. 1) may be configured to apply the determined sensor sensitivity to the temperature compensated work electrode current signal in order to determine the corresponding calibrated analyte value or level. That is, the calibrated analyte value may be determined by dividing the temperature compensated work electrode current signal by the determined sensor sensitivity. In one aspect, a time-series of the calibrated analyte values may be acquired by the receiver unit 104 (FIG. 1) in real-time, and may be used to determine analyte rate-of-change and other analyte signal metrics and/or statistics. In addition, the calibrated analyte values may also be used to drive alarms or alerts that inform the patient whose analyte is being monitored of analyte level conditions that require attention. In addition, in accordance with one aspect of the present invention, the receiver unit 104 may be configured to determine whether the sensor sensitivity range is within a valid range.
  • [0060]
    FIG. 7A illustrates the transmission of the control signal from the transmitter processor in accordance with one embodiment of the present invention. More particularly, FIG. 7A illustrates the poise voltage square wave with 50% duty cycle with one minute time periods is shown, where the poise voltage square wave amplitude is switched from 40 mV to −600 mV as in normal operating mode. FIG. 7B illustrates the measured response to the control signal from the transmitter processor shown in FIG. 7A in accordance with one embodiment of the present invention. More specifically, the measured response which is associated with the analyte level measured by the sensor 101 from the interstitial fluid of a patient as modulated by the control signal from the transmitter processor 204 is illustrated with one minute time periods.
  • [0061]
    FIG. 8 is a tabular illustration of a lookup table for sensor sensitivity for use with the calibration procedure in accordance with one embodiment of the present invention. More specifically, in one embodiment, the lookup table shown in FIG. 8 is stored in a memory unit (not shown) of the transmitter unit 102 (or alternatively, in the transmitter processor 204) and may be accessed by the transmitter processor 204 to retrieve a corresponding sensitivity value associated with the determined measured response difference.
  • [0062]
    FIG. 9 is a flowchart illustrating the analyte sensor sensitivity estimation procedure in accordance with another embodiment of the present invention. Referring to FIG. 9, in one embodiment, a control signal from the transmitter processor 204 (FIG. 2) is provided 910 to the analog interface 201 of the transmitter unit 102, and a response to the applied control signal is determined 920. Thereafter, the difference or variance in the determined response to the control signal between the beginning and end of the half duty cycle is determined 930. As can be seen, in one embodiment, steps 910 to 930 are substantially similar to steps 610 to 630, respectively described above.
  • [0063]
    Referring back to FIG. 9, after determining the measured response variance or difference between the beginning and end of the half duty cycle, it is determined whether the number of transmitted or applied control signals exceed a predetermined number or count 940. If it is determined that the number of transmitted or applied control signals do not exceed the predetermined number or count, then a control signal counter (for example, provided in the transmitter unit 102) is incremented by one count 960, and the routine returns to the beginning where another control signal is provided to the analog interface 201 of the transmitter unit 102.
  • [0064]
    On the other hand, if it is determined that the number of transmitted or applied control signals exceeds the predetermined number or count, then the sensor sensitivity may be determined based on the determined difference in the response 950. That is, as discussed above, the difference in measured response in one embodiment is compared to a predetermined sensor parameter such as sensor sensitivity that may be stored in a look up table, for example, in the transmitter processor 204 memory unit. In one aspect, the look up table may include a calculated measured response difference for the sensor and corresponding sensor sensitivities based on characteristics of the sensor. Furthermore, as discussed above, in one embodiment, the calibrated analyte value or level may be determined by, for example, dividing the corresponding sensor signal (e.g., work electrode current signal) level by the determined sensor sensitivity value.
  • [0065]
    Within the scope of the present invention, the perturbations to the analyte sensors may be provided by, for example, altering the poise voltage in time. Alternatively, an additional electrical current signal may be provided to the sensor work or counter electrodes via an AC coupling, where the level of the additional electrical current signal may be varied in time by the control signal in a manner similar as discussed above. Still in accordance with another embodiment, the work/counter electrode current path may be opened and closed in a time varying manner controlled by the control signal. Yet still another embodiment may provide a variable resistance in the work/counter electrode current path, where the variable resistance is varied in time as controlled by the control signal.
  • [0066]
    In another aspect of the present invention, the transcutaneously positioned sensor may be perturbed with a mechanical transducer controlled in time and amplitude by a predetermined control signal. In one embodiment, mechanical transducers may include those that can provide physical signals of vibration, acoustics, thermal or electro-magnetic media, for example. Broadly, any suitable mechanism to apply perturbations to the transcutaneously positioned sensor may be used to the extent that the measured response may be analyzed by the signal processing component such as, for example, the transmitter unit processor 204 to estimate one or more sensor properties based on the signal response induced by the perturbations. For example, vibration perturbations may induce fluctuations in the sensor membrane that could be detected in the measured response transients, which may be correlated with membrane thickness and thus provide a measure of the sensitivity of the sensor.
  • [0067]
    In addition, in accordance with the various embodiments of the present invention, there are provided a variety of time-varying controls signals that may be applied, along with a variety of techniques used to analyze the measured response and estimate the sensor parameter of interest. Some of these control signals may be appropriate to induce a measured response that is more informative about a specific sensor parameter than other control signals, and some control signals may be more practical to implement than others. As discussed previously, a square-wave control signal may be employed in one embodiment. Variations in this type of control signal may be suitably used where the positive and negative amplitudes are at different levels, the duty cycle is other than 50%, or the period is other than 1 minute.
  • [0068]
    In another embodiment of the present invention, a feedback mechanism may be provided where the duty cycle is varied to achieve a desired response, such as a specific transient response time. In this case, the final duty cycle is the parameter that is correlated with the sensor parameter to be estimated. This feedback technique may be extended to other types of control signals, mentioned below, and other characteristics of the signal such as phase, amplitude and frequency may be varied to achieve a desired response.
  • [0069]
    Alternatively, a sine wave may be used as the control signal discussed above rather than a square wave. Still alternatively, a series of sine waves at different frequencies, or a chirp signal may be used as control signals in one embodiment of the present invention. The measured response of these perturbation signals may then be analyzed using standard spectral analysis techniques. Based on the spectral analysis, metrics may be determined that are correlated with the sensor parameter to be estimated.
  • [0070]
    In accordance with yet another embodiment, an impulse signal, or a series of impulse signals may be alternatively used as control signals. The measured response of these perturbation signals may be analyzed using known impulse response analysis techniques. For example, the maximum height of the measured response may be used to determine the associated sensor sensitivity. Alternatively, other signal metrics such as the time to reach the maximum height of the measured response, the area under the curve of the measured response, the slope of the measured response may be correlated with the sensor parameter to be estimated.
  • [0071]
    In still another embodiment, pseudo-random modulation similar to those used in spread-spectrum communication systems may be used as the control signals. The measured response of these perturbation signals may be analyzed using known spread-spectrum analysis techniques. Based on this analysis, metrics may be determined that are correlated with the sensor parameter to be estimated. In addition, the response signal may be demodulated using spread-spectrum techniques to recover the analyte level.
  • [0072]
    For some of the control signal/response measurement analysis techniques discussed above, the relative phase between the control signal and the measured response may be used to analyze the measured response to the perturbation. For some of the control signal/response measurement analysis techniques discussed above, multiple metrics may be determined. One or more of these metrics may be used to estimate the sensor parameter of interest. For example, in one embodiment, a multidimensional table lookup may be used where one dimension includes the sensor parameter of interest, and the other dimensions may each be associated with a different metric that characterizes the measured response. More specifically, by way of illustration, in the impulse response approach described above, both the maximum height and the time to reach the height of the measured response may be determined. In this case, a three dimensional lookup table may be used.
  • [0073]
    As discussed above, in one embodiment, a lookup table may be used to correlate a metric associated with the measured response with a sensor parameter of interest (for example, sensitivity). Alternatively, a mathematical function that relates the measured response metric with the sensor parameter may be used. The sensor parameter may then be determined based on the measured response metric as an input. In another aspect, the estimate of the sensor parameter may be determined for many measurements using, for example, the least squares approach.
  • [0074]
    In addition, within the scope of the present invention, the control signal may be transmitted to the analog interface 201 at predetermined time periods during the life of the sensor. Alternatively, the transmitter processor 204 may be configured to transmit the control signal only during the time periods when sensor calibration is desired or if some other factor, such as a detection of sensitivity instability, determines that sensor calibration is required.
  • [0075]
    Moreover, in one embodiment, other system parameters in addition to sensitivity may be associated with the measured response from the analog interface 201 in response to the control signal from the transmitter processor 204. These include, but are not limited to, sensor response time, sensor response linearity, sensitivity stability and sensor failure. Accurately estimated sensor response time can be useful for incorporation into algorithms that compensate for errors due to lag in the analyte measurement system. Knowledge of the non-linearity in the sensor response (non-linearity means that the sensitivity is not constant over the entire range to measured response) allows for compensation of errors caused by this non-linearity.
  • [0076]
    Detection of sensitivity instability (that is, detection when the sensitivity has changed value) may be used to accurately determine the new sensitivity. For example, if instability has been detected by the signal processing component, it can direct the control processing component such as the transmitter unit processor 204 to initiate a control signal that is more appropriate to accurately estimating the sensitivity. Also, detecting a sudden, substantial change in sensitivity may be used to identify that a sensor may have failed.
  • [0077]
    While the control signal may be used to determine the sensor sensitivity, in one embodiment, the resulting modulation in the measured response may be removed by, for example, one or more signal filters to recover the glucose signal. In one aspect, a standard signal filter may be used to remove the high frequency content of the signal due to modulation by the perturbation control signal, and recover the lower frequency content that represents the analyte level. In another aspect, the modulation may be deconvolved using the control signal, the calculated sensor response and the estimated sensitivity.
  • [0078]
    Furthermore, there are several approaches to measure a sensor's response to the perturbation signals in order to estimate desired properties or characteristics of the sensor. For example, in one embodiment, the electrical current that flows through the work (and counter) electrode may be measured. Alternatively, the perturbation response in the counter electrode voltage may be alternatively measured. The measured counter voltage response may be analyzed using same or similar techniques as the measured work current response. In another embodiment, both work current and counter voltage responses may be measured and analyzed.
  • [0079]
    In the manner described above, within the scope of the present invention, there is provided method and system for performing calibration of analyte sensors based on the sensor dynamic behavior and on a substantially real time basis such that sensor calibrations based on blood glucose measurements may be minimized further to improve the accuracy of the analyte sensor data.
  • [0080]
    In accordance with the various embodiments of the present invention, the transmitter processor 204 may include a microcontroller, or alternatively, may be implemented with digital logic such as a gate array or similar logic devices. In addition, in one embodiment, the measured response variance as well as the estimated sensor sensitivity determined by the transmitter processor 204 may be transmitted to the receiver unit 104 (FIG. 1) in the analyte monitoring system 100 in addition to the analyte sensor measurements (for example, the work electrode current measurements detected by the sensor 101).
  • [0081]
    In a further aspect, some of the processing may be performed by the receiver unit 104 (FIG. 1) rather than by the transmitter processor 204 such that the transmitter unit 102 may be configured to periodically transmit the measured response variance to the receiver unit 104, and the receiver unit processing and storage unit 307 (FIG. 3) may be configured to perform the sensor sensitivity determination based on the lookup table which may be stored in a memory device (not shown) in the receiver unit 104.
  • [0082]
    A method of calibrating an analyte sensor in one embodiment includes applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured response.
  • [0083]
    The level of the control signal may in one embodiment vary in time.
  • [0084]
    In one aspect, the control signal may include a square wave signal, where the square wave signal may be applied to a poise voltage.
  • [0085]
    In a further aspect, detecting the measured response may include determining a work electrode current signal.
  • [0086]
    In still another aspect, the variance may be determined based on comparing the difference between the beginning and end of the half duty cycle of the measured response to the control signal.
  • [0087]
    Moreover, estimating the sensor sensitivity may include retrieving a predetermined sensor sensitivity corresponding to the determined variance in the detected measured response.
  • [0088]
    The method may also include determining a validity of the estimated sensor sensitivity.
  • [0089]
    In addition, the method may also include determining analyte level based on the estimated sensor sensitivity.
  • [0090]
    The sensor in one embodiment may include an analyte sensor.
  • [0091]
    An analyte sensor calibration device in accordance with another embodiment includes a processor configured to apply a control signal, detect a measured response to the control signal, determine a variance in the detected measured response, and estimate a sensor sensitivity based on the variance in the detected measured response.
  • [0092]
    The processor may be configured to vary the level of the control signal with time.
  • [0093]
    In another aspect, the processor may be configured to apply a square wave signal to a poise voltage.
  • [0094]
    The processor in a further aspect may be configured to determine a work electrode current signal of an analyte sensor operatively coupled to the processor.
  • [0095]
    Moreover, the processor may be configured to determine the variance based on comparing the difference between the beginning and end of the half duty cycle of the measured response to the control signal.
  • [0096]
    In addition, the processor in a further aspect may be configured to retrieve a predetermined sensor sensitivity corresponding to the determined variance in the detected measured response.
  • [0097]
    The processor may be operatively coupled to a data receiver unit configured to determine a validity of the estimated sensor sensitivity, where the data receiver unit may be configured to determine an analyte level based on the estimated sensor sensitivity.
  • [0098]
    The various processes described above including the processes performed by the transmitter processor 204 in the software application execution environment in the transmitter unit 102 including the processes and routines described in conjunction with FIGS. 4-6 and 9, may be embodied as computer programs developed using an object oriented language that allows the modeling of complex systems with modular objects to create abstractions that are representative of real world, physical objects and their interrelationships. The software required to carry out the inventive process, which may be stored in the memory (not shown) of the transmitter unit 102 may be developed by a person of ordinary skill in the art and may include one or more computer program products.
  • [0099]
    Various other modifications and alterations in the structure and method of operation of this invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. It is intended that the following claims define the scope of the present invention and that structures and methods within the scope of these claims and their equivalents be covered thereby.

Claims (4)

  1. 1. (canceled)
  2. 2. A system comprising:
    means for obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;
    means for determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and
    means for assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend;
    further comprising means for generating an alert signal responsive to a comparison of the at least one metric assessing the underlying trend with at least one predetermined threshold.
  3. 3. A system comprising:
    means for obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;
    means for determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and
    means for assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend;
    wherein the means for assessing the reliability of the at least one sensor signal comprises means for comparing the at least one metric assessing the underlying trend with at least a first predetermined threshold and a second predetermined threshold.
  4. 4. A system comprising:
    means for obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;
    means for determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and
    means for assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend;
    further comprising:
    means for acquiring the at least one sensor signal from one or more subcutaneous glucose sensors, wherein the means for determine the at least one metric assessing the underlying trend reflects an apparent reliability of the at least one sensor signal that is acquired from the one or more subcutaneous glucose sensors.
US15344500 2006-08-09 2016-11-04 Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System Abandoned US20170049369A1 (en)

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US13766673 US9408566B2 (en) 2006-08-09 2013-02-13 Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US15209743 US9833181B2 (en) 2006-08-09 2016-07-13 Method and system for providing calibration of an analyte sensor in an analyte monitoring system
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Families Citing this family (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
US8626257B2 (en) * 2003-08-01 2014-01-07 Dexcom, Inc. Analyte sensor
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
US8425417B2 (en) * 2003-12-05 2013-04-23 Dexcom, Inc. Integrated device for continuous in vivo analyte detection and simultaneous control of an infusion device
US20080197024A1 (en) * 2003-12-05 2008-08-21 Dexcom, Inc. Analyte sensor
US8771183B2 (en) 2004-02-17 2014-07-08 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US20090082693A1 (en) * 2004-12-29 2009-03-26 Therasense, Inc. Method and apparatus for providing temperature sensor module in a data communication system
US8571624B2 (en) 2004-12-29 2013-10-29 Abbott Diabetes Care Inc. Method and apparatus for mounting a data transmission device in a communication system
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US7731657B2 (en) 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US7883464B2 (en) * 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US8880138B2 (en) 2005-09-30 2014-11-04 Abbott Diabetes Care Inc. Device for channeling fluid and methods of use
US9521968B2 (en) 2005-09-30 2016-12-20 Abbott Diabetes Care Inc. Analyte sensor retention mechanism and methods of use
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US9398882B2 (en) * 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
CA2636034A1 (en) * 2005-12-28 2007-10-25 Abbott Diabetes Care Inc. Medical device insertion
US7697967B2 (en) 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US7736310B2 (en) * 2006-01-30 2010-06-15 Abbott Diabetes Care Inc. On-body medical device securement
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US7826879B2 (en) * 2006-02-28 2010-11-02 Abbott Diabetes Care Inc. Analyte sensors and methods of use
US7981034B2 (en) 2006-02-28 2011-07-19 Abbott Diabetes Care Inc. Smart messages and alerts for an infusion delivery and management system
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US7801582B2 (en) 2006-03-31 2010-09-21 Abbott Diabetes Care Inc. Analyte monitoring and management system and methods therefor
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US20090105569A1 (en) * 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
US20080071157A1 (en) * 2006-06-07 2008-03-20 Abbott Diabetes Care, Inc. Analyte monitoring system and method
US20090171269A1 (en) * 2006-06-29 2009-07-02 Abbott Diabetes Care, Inc. Infusion Device and Methods Therefor
US8932216B2 (en) 2006-08-07 2015-01-13 Abbott Diabetes Care Inc. Method and system for providing data management in integrated analyte monitoring and infusion system
US8206296B2 (en) 2006-08-07 2012-06-26 Abbott Diabetes Care Inc. Method and system for providing integrated analyte monitoring and infusion system therapy management
US7653425B2 (en) 2006-08-09 2010-01-26 Abbott Diabetes Care Inc. Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US7618369B2 (en) 2006-10-02 2009-11-17 Abbott Diabetes Care Inc. Method and system for dynamically updating calibration parameters for an analyte sensor
US8298142B2 (en) * 2006-10-04 2012-10-30 Dexcom, Inc. Analyte sensor
US8478377B2 (en) * 2006-10-04 2013-07-02 Dexcom, Inc. Analyte sensor
US8364230B2 (en) * 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8562528B2 (en) * 2006-10-04 2013-10-22 Dexcom, Inc. Analyte sensor
US8447376B2 (en) * 2006-10-04 2013-05-21 Dexcom, Inc. Analyte sensor
US8449464B2 (en) 2006-10-04 2013-05-28 Dexcom, Inc. Analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8275438B2 (en) * 2006-10-04 2012-09-25 Dexcom, Inc. Analyte sensor
US8532730B2 (en) * 2006-10-04 2013-09-10 Dexcom, Inc. Analyte sensor
US8425416B2 (en) * 2006-10-04 2013-04-23 Dexcom, Inc. Analyte sensor
US9788771B2 (en) * 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US9259175B2 (en) 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US7630748B2 (en) 2006-10-25 2009-12-08 Abbott Diabetes Care Inc. Method and system for providing analyte monitoring
JP2010508091A (en) 2006-10-26 2010-03-18 アボット ダイアベティス ケア インコーポレイテッドAbbott Diabetes Care Inc. The method for detecting a decrease sensitivity of the analyte sensor in real time systems, and computer program products
US20080161666A1 (en) * 2006-12-29 2008-07-03 Abbott Diabetes Care, Inc. Analyte devices and methods
US8121857B2 (en) 2007-02-15 2012-02-21 Abbott Diabetes Care Inc. Device and method for automatic data acquisition and/or detection
US20080199894A1 (en) * 2007-02-15 2008-08-21 Abbott Diabetes Care, Inc. Device and method for automatic data acquisition and/or detection
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US9636450B2 (en) 2007-02-19 2017-05-02 Udo Hoss Pump system modular components for delivering medication and analyte sensing at seperate insertion sites
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US9029157B2 (en) * 2007-04-12 2015-05-12 Nipro Diagnostics, Inc. Error detection and rejection for a diagnostic testing system
CA2683959C (en) 2007-04-14 2017-08-29 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
US9204827B2 (en) 2007-04-14 2015-12-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
WO2009096992A1 (en) * 2007-04-14 2009-08-06 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in medical communication system
US7768387B2 (en) 2007-04-14 2010-08-03 Abbott Diabetes Care Inc. Method and apparatus for providing dynamic multi-stage signal amplification in a medical device
US9008743B2 (en) 2007-04-14 2015-04-14 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
EP2137637A4 (en) 2007-04-14 2012-06-20 Abbott Diabetes Care Inc Method and apparatus for providing data processing and control in medical communication system
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US9125548B2 (en) 2007-05-14 2015-09-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US7996158B2 (en) 2007-05-14 2011-08-09 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8260558B2 (en) * 2007-05-14 2012-09-04 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8560038B2 (en) 2007-05-14 2013-10-15 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US20090006034A1 (en) * 2007-05-14 2009-01-01 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in a medical communication system
US8103471B2 (en) 2007-05-14 2012-01-24 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8140312B2 (en) 2007-05-14 2012-03-20 Abbott Diabetes Care Inc. Method and system for determining analyte levels
US8600681B2 (en) 2007-05-14 2013-12-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8444560B2 (en) 2007-05-14 2013-05-21 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US20080312845A1 (en) * 2007-05-14 2008-12-18 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in a medical communication system
US8239166B2 (en) 2007-05-14 2012-08-07 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
EP2156348A2 (en) 2007-05-30 2010-02-24 Bayer Healthcare, LLC System and method for managing health data
WO2008150917A1 (en) 2007-05-31 2008-12-11 Abbott Diabetes Care, Inc. Insertion devices and methods
US8597188B2 (en) 2007-06-21 2013-12-03 Abbott Diabetes Care Inc. Health management devices and methods
CA2690870C (en) * 2007-06-21 2017-07-11 Abbott Diabetes Care Inc. Health monitor
US8641618B2 (en) * 2007-06-27 2014-02-04 Abbott Diabetes Care Inc. Method and structure for securing a monitoring device element
US8160900B2 (en) * 2007-06-29 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring and management device and method to analyze the frequency of user interaction with the device
US7768386B2 (en) * 2007-07-31 2010-08-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8834366B2 (en) 2007-07-31 2014-09-16 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor calibration
US20090036760A1 (en) * 2007-07-31 2009-02-05 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in a medical communication system
US8216138B1 (en) 2007-10-23 2012-07-10 Abbott Diabetes Care Inc. Correlation of alternative site blood and interstitial fluid glucose concentrations to venous glucose concentration
US8374668B1 (en) 2007-10-23 2013-02-12 Abbott Diabetes Care Inc. Analyte sensor with lag compensation
US8409093B2 (en) 2007-10-23 2013-04-02 Abbott Diabetes Care Inc. Assessing measures of glycemic variability
US8377031B2 (en) 2007-10-23 2013-02-19 Abbott Diabetes Care Inc. Closed loop control system with safety parameters and methods
US20090164251A1 (en) * 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Method and apparatus for providing treatment profile management
US20090164239A1 (en) * 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Dynamic Display Of Glucose Information
US8473022B2 (en) 2008-01-31 2013-06-25 Abbott Diabetes Care Inc. Analyte sensor with time lag compensation
CA2715628A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
US8583205B2 (en) 2008-03-28 2013-11-12 Abbott Diabetes Care Inc. Analyte sensor calibration management
US8346335B2 (en) 2008-03-28 2013-01-01 Abbott Diabetes Care Inc. Analyte sensor calibration management
US20090259118A1 (en) * 2008-03-31 2009-10-15 Abbott Diabetes Care Inc. Shallow Implantable Analyte Sensor with Rapid Physiological Response
EP2982383A1 (en) * 2008-04-10 2016-02-10 Abbott Diabetes Care, Inc. Method for sterilizing an analyte sensor
US7826382B2 (en) 2008-05-30 2010-11-02 Abbott Diabetes Care Inc. Close proximity communication device and methods
US8591410B2 (en) 2008-05-30 2013-11-26 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
US20090300616A1 (en) * 2008-05-30 2009-12-03 Abbott Diabetes Care, Inc. Automated task execution for an analyte monitoring system
US8924159B2 (en) 2008-05-30 2014-12-30 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
WO2010009172A1 (en) 2008-07-14 2010-01-21 Abbott Diabetes Care Inc. Closed loop control system interface and methods
US9392969B2 (en) * 2008-08-31 2016-07-19 Abbott Diabetes Care Inc. Closed loop control and signal attenuation detection
US8734422B2 (en) 2008-08-31 2014-05-27 Abbott Diabetes Care Inc. Closed loop control with improved alarm functions
US20100057040A1 (en) * 2008-08-31 2010-03-04 Abbott Diabetes Care, Inc. Robust Closed Loop Control And Methods
US8622988B2 (en) 2008-08-31 2014-01-07 Abbott Diabetes Care Inc. Variable rate closed loop control and methods
US8452116B1 (en) 2008-09-19 2013-05-28 Adobe Systems Incorporated Estimating sensor sensitivity
US8219173B2 (en) * 2008-09-30 2012-07-10 Abbott Diabetes Care Inc. Optimizing analyte sensor calibration
US20100082364A1 (en) * 2008-09-30 2010-04-01 Abbott Diabetes Care, Inc. Medical Information Management
US8986208B2 (en) 2008-09-30 2015-03-24 Abbott Diabetes Care Inc. Analyte sensor sensitivity attenuation mitigation
US8107634B2 (en) * 2008-10-25 2012-01-31 The Boeing Company High intensity calibration device
US9326707B2 (en) 2008-11-10 2016-05-03 Abbott Diabetes Care Inc. Alarm characterization for analyte monitoring devices and systems
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US8224415B2 (en) 2009-01-29 2012-07-17 Abbott Diabetes Care Inc. Method and device for providing offset model based calibration for analyte sensor
US20100198034A1 (en) 2009-02-03 2010-08-05 Abbott Diabetes Care Inc. Compact On-Body Physiological Monitoring Devices and Methods Thereof
EP2400886A4 (en) * 2009-02-26 2014-07-02 Abbott Diabetes Care Inc Improved analyte sensors and methods of making and using the same
WO2010114942A1 (en) * 2009-03-31 2010-10-07 Abbott Diabetes Care Inc. Precise fluid dispensing method and device
WO2010121084A1 (en) 2009-04-15 2010-10-21 Abbott Diabetes Care Inc. Analyte monitoring system having an alert
EP2425210A4 (en) * 2009-04-28 2013-01-09 Abbott Diabetes Care Inc Dynamic analyte sensor calibration based on sensor stability profile
WO2010127050A1 (en) * 2009-04-28 2010-11-04 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
US8368556B2 (en) 2009-04-29 2013-02-05 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
EP2425209A4 (en) 2009-04-29 2013-01-09 Abbott Diabetes Care Inc Method and system for providing real time analyte sensor calibration with retrospective backfill
US8617381B2 (en) * 2009-06-23 2013-12-31 Bayer Healthcare Llc System and apparatus for determining temperatures in a fluid analyte system
US8613892B2 (en) 2009-06-30 2013-12-24 Abbott Diabetes Care Inc. Analyte meter with a moveable head and methods of using the same
CN104799866A (en) 2009-07-23 2015-07-29 雅培糖尿病护理公司 The analyte monitoring device
US8641671B2 (en) 2009-07-30 2014-02-04 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8478557B2 (en) 2009-07-31 2013-07-02 Abbott Diabetes Care Inc. Method and apparatus for providing analyte monitoring system calibration accuracy
CA2765712A1 (en) * 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Medical devices and methods
EP2473422A4 (en) 2009-08-31 2014-09-17 Abbott Diabetes Care Inc Displays for a medical device
EP2473098A4 (en) * 2009-08-31 2014-04-09 Abbott Diabetes Care Inc Analyte signal processing device and methods
EP2473099A4 (en) 2009-08-31 2015-01-14 Abbott Diabetes Care Inc Analyte monitoring system and methods for managing power and noise
EP2482720A4 (en) 2009-09-29 2014-04-23 Abbott Diabetes Care Inc Method and apparatus for providing notification function in analyte monitoring systems
US9351669B2 (en) 2009-09-30 2016-05-31 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
WO2011053881A1 (en) 2009-10-30 2011-05-05 Abbott Diabetes Care Inc. Method and apparatus for detecting false hypoglycemic conditions
US9041730B2 (en) 2010-02-12 2015-05-26 Dexcom, Inc. Receivers for analyzing and displaying sensor data
US9326709B2 (en) 2010-03-10 2016-05-03 Abbott Diabetes Care Inc. Systems, devices and methods for managing glucose levels
CA2766693A1 (en) 2010-03-24 2011-09-29 Abbott Diabetes Care Inc. Medical device inserters and processes of inserting and using medical devices
US8635046B2 (en) 2010-06-23 2014-01-21 Abbott Diabetes Care Inc. Method and system for evaluating analyte sensor response characteristics
US9572534B2 (en) 2010-06-29 2017-02-21 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US9084570B2 (en) 2010-10-08 2015-07-21 Roche Diagnostics Operations, Inc. Electrochemical sensor having symmetrically distributed analyte sensitive areas
CN107019515A (en) 2011-02-28 2017-08-08 雅培糖尿病护理公司 Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
US9743862B2 (en) 2011-03-31 2017-08-29 Abbott Diabetes Care Inc. Systems and methods for transcutaneously implanting medical devices
WO2012142502A3 (en) * 2011-04-15 2013-01-10 Dexcom Inc. Advanced analyte sensor calibration and error detection
WO2013066849A1 (en) 2011-10-31 2013-05-10 Abbott Diabetes Care Inc. Model based variable risk false glucose threshold alarm prevention mechanism
WO2013066873A1 (en) 2011-10-31 2013-05-10 Abbott Diabetes Care Inc. Electronic devices having integrated reset systems and methods thereof
US20130116526A1 (en) 2011-11-09 2013-05-09 Telcare, Inc. Handheld Blood Glucose Monitoring Device with Messaging Capability
US9317656B2 (en) 2011-11-23 2016-04-19 Abbott Diabetes Care Inc. Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof
US8710993B2 (en) 2011-11-23 2014-04-29 Abbott Diabetes Care Inc. Mitigating single point failure of devices in an analyte monitoring system and methods thereof
US9339217B2 (en) 2011-11-25 2016-05-17 Abbott Diabetes Care Inc. Analyte monitoring system and methods of use
EP2713879B1 (en) 2011-12-11 2017-07-26 Abbott Diabetes Care, Inc. Analyte sensor devices, connections, and methods
EP2825096A1 (en) 2012-03-16 2015-01-21 Dexcom, Inc. Systems and methods for processing analyte sensor data
CN102735780B (en) * 2012-06-27 2014-07-30 常州方圆制药有限公司 Method for monitoring 3,2',6'-tri-N-acetyl gentamicin Cla content
US9907492B2 (en) 2012-09-26 2018-03-06 Abbott Diabetes Care Inc. Method and apparatus for improving lag correction during in vivo measurement of analyte concentration with analyte concentration variability and range data
US9675290B2 (en) 2012-10-30 2017-06-13 Abbott Diabetes Care Inc. Sensitivity calibration of in vivo sensors used to measure analyte concentration
US9119529B2 (en) 2012-10-30 2015-09-01 Dexcom, Inc. Systems and methods for dynamically and intelligently monitoring a host's glycemic condition after an alert is triggered
US9474475B1 (en) 2013-03-15 2016-10-25 Abbott Diabetes Care Inc. Multi-rate analyte sensor data collection with sample rate configurable signal processing
US9486171B2 (en) 2013-03-15 2016-11-08 Tandem Diabetes Care, Inc. Predictive calibration
DE102014111805A1 (en) * 2014-08-19 2016-02-25 Krohne Messtechnik Gmbh Device, sensor unit and the transmitter for determining a measured variable
CN107810409A (en) * 2015-07-06 2018-03-16 雷迪奥米特医学公司 Crea sensor corrected for inhibition of calcium method
US20170172472A1 (en) * 2015-12-21 2017-06-22 Dexcom, Inc. Continuous analyte monitoring system power conservation

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030050546A1 (en) * 2001-06-22 2003-03-13 Desai Shashi P. Methods for improving the performance of an analyte monitoring system
US20030235817A1 (en) * 2002-03-22 2003-12-25 Miroslaw Bartkowiak Microprocessors, devices, and methods for use in analyte monitoring systems
US20040024553A1 (en) * 2002-03-08 2004-02-05 Monfre Stephen L. Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers
US20050027180A1 (en) * 2003-08-01 2005-02-03 Goode Paul V. System and methods for processing analyte sensor data
US20080039702A1 (en) * 2006-08-09 2008-02-14 Abbott Diabetes Care, Inc. Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System
US7713574B2 (en) * 2004-07-13 2010-05-11 Dexcom, Inc. Transcutaneous analyte sensor
US7751864B2 (en) * 2007-03-01 2010-07-06 Roche Diagnostics Operations, Inc. System and method for operating an electrochemical analyte sensor
US7857760B2 (en) * 2004-07-13 2010-12-28 Dexcom, Inc. Analyte sensor
US7905833B2 (en) * 2004-07-13 2011-03-15 Dexcom, Inc. Transcutaneous analyte sensor
US7996158B2 (en) * 2007-05-14 2011-08-09 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8239166B2 (en) * 2007-05-14 2012-08-07 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8260558B2 (en) * 2007-05-14 2012-09-04 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8444560B2 (en) * 2007-05-14 2013-05-21 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8543354B2 (en) * 2010-06-23 2013-09-24 Medtronic Minimed, Inc. Glucose sensor signal stability analysis
US8560038B2 (en) * 2007-05-14 2013-10-15 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8600681B2 (en) * 2007-05-14 2013-12-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8657746B2 (en) * 2010-10-28 2014-02-25 Medtronic Minimed, Inc. Glucose sensor signal purity analysis

Family Cites Families (660)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1191363A (en) 1968-02-19 1970-05-13 Pavelle Ltd Improvements in or relating to Electronic Thermostats.
US3949388A (en) * 1972-11-13 1976-04-06 Monitron Industries, Inc. Physiological sensor and transmitter
US3926760A (en) 1973-09-28 1975-12-16 Du Pont Process for electrophoretic deposition of polymer
US4245634A (en) * 1975-01-22 1981-01-20 Hospital For Sick Children Artificial beta cell
US4036749A (en) 1975-04-30 1977-07-19 Anderson Donald R Purification of saline water
US3960497A (en) 1975-08-19 1976-06-01 Beckman Instruments, Inc. Chemical analyzer with automatic calibration
US4033330A (en) 1975-09-08 1977-07-05 Hewlett-Packard Company Transcutaneous pH measuring instrument
US4055175A (en) 1976-05-07 1977-10-25 Miles Laboratories, Inc. Blood glucose control apparatus
US4129128A (en) 1977-02-23 1978-12-12 Mcfarlane Richard H Securing device for catheter placement assembly
US4344438A (en) 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
CA1146607A (en) 1978-12-07 1983-05-17 Robert B. Phillips Target apparatus
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
DE3019870C2 (en) 1979-07-12 1988-01-28 Univ Karlova
US4425920A (en) * 1980-10-24 1984-01-17 Purdue Research Foundation Apparatus and method for measurement and control of blood pressure
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4392849A (en) 1981-07-27 1983-07-12 The Cleveland Clinic Foundation Infusion pump controller
DE3138194A1 (en) 1981-09-25 1983-04-14 Basf Ag Water-insoluble porous material protein whose production and use
US4431004A (en) 1981-10-27 1984-02-14 Bessman Samuel P Implantable glucose sensor
US4494950A (en) * 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
FI831399L (en) 1982-04-29 1983-10-30 Agripat Sa Kontaktlinsen of haerdad polyvinylalkohol
EP0098592A3 (en) 1982-07-06 1985-08-21 Fujisawa Pharmaceutical Co., Ltd. Portable artificial pancreas
US4509531A (en) * 1982-07-28 1985-04-09 Teledyne Industries, Inc. Personal physiological monitor
US4464170A (en) 1982-09-29 1984-08-07 Miles Laboratories, Inc. Blood glucose control apparatus and method
US4527240A (en) 1982-12-29 1985-07-02 Kvitash Vadim I Balascopy method for detecting and rapidly evaluating multiple imbalances within multi-parametric systems
CA1226036A (en) 1983-05-05 1987-08-25 Irving J. Higgins Analytical equipment and sensor electrodes therefor
US5509410A (en) * 1983-06-06 1996-04-23 Medisense, Inc. Strip electrode including screen printing of a single layer
US4538616A (en) 1983-07-25 1985-09-03 Robert Rogoff Blood sugar level sensing and monitoring transducer
DE3429596A1 (en) 1984-08-10 1986-02-20 Siemens Ag Device for the physiological frequency control of a stimulation electrode provided with a pacemaker
CA1254091A (en) 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
US4847785A (en) 1985-01-22 1989-07-11 International Business Machines Corp. Interactive display for trend or bar graph
US5279294A (en) * 1985-04-08 1994-01-18 Cascade Medical, Inc. Medical diagnostic system
US4671288A (en) 1985-06-13 1987-06-09 The Regents Of The University Of California Electrochemical cell sensor for continuous short-term use in tissues and blood
US4890620A (en) * 1985-09-20 1990-01-02 The Regents Of The University Of California Two-dimensional diffusion glucose substrate sensing electrode
US4757022A (en) 1986-04-15 1988-07-12 Markwell Medical Institute, Inc. Biological fluid measuring device
US4703756A (en) 1986-05-06 1987-11-03 The Regents Of The University Of California Complete glucose monitoring system with an implantable, telemetered sensor module
US4731726A (en) * 1986-05-19 1988-03-15 Healthware Corporation Patient-operated glucose monitor and diabetes management system
US5055171A (en) 1986-10-06 1991-10-08 T And G Corporation Ionic semiconductor materials and applications thereof
US5002054A (en) * 1987-02-25 1991-03-26 Ash Medical Systems, Inc. Interstitial filtration and collection device and method for long-term monitoring of physiological constituents of the body
US4777953A (en) 1987-02-25 1988-10-18 Ash Medical Systems, Inc. Capillary filtration and collection method for long-term monitoring of blood constituents
US4854322A (en) 1987-02-25 1989-08-08 Ash Medical Systems, Inc. Capillary filtration and collection device for long-term monitoring of blood constituents
US4759828A (en) 1987-04-09 1988-07-26 Nova Biomedical Corporation Glucose electrode and method of determining glucose
US4749985A (en) 1987-04-13 1988-06-07 United States Of America As Represented By The United States Department Of Energy Functional relationship-based alarm processing
EP0290683A3 (en) 1987-05-01 1988-12-14 Diva Medical Systems B.V. Diabetes management system and apparatus
GB8725936D0 (en) 1987-11-05 1987-12-09 Genetics Int Inc Sensing system
US4925268A (en) 1988-07-25 1990-05-15 Abbott Laboratories Fiber-optic physiological probes
EP0353328A1 (en) * 1988-08-03 1990-02-07 Dräger Nederland B.V. A polarographic-amperometric three-electrode sensor
US5340722A (en) 1988-08-24 1994-08-23 Avl Medical Instruments Ag Method for the determination of the concentration of an enzyme substrate and a sensor for carrying out the method
US4995402A (en) * 1988-10-12 1991-02-26 Thorne, Smith, Astill Technologies, Inc. Medical droplet whole blood and like monitoring
US5360404A (en) 1988-12-14 1994-11-01 Inviro Medical Devices Ltd. Needle guard and needle assembly for syringe
US5068536A (en) 1989-01-19 1991-11-26 Futrex, Inc. Method for providing custom calibration for near infrared instruments for measurement of blood glucose
DK0385805T3 (en) * 1989-03-03 1996-09-23 Edward W Stark A method and apparatus for signal processing
US5312762A (en) * 1989-03-13 1994-05-17 Guiseppi Elie Anthony Method of measuring an analyte by measuring electrical resistance of a polymer film reacting with the analyte
JPH02298855A (en) 1989-03-20 1990-12-11 Assoc Univ Inc Electrochemical biosensor using immobilized enzyme and redox polymer
US4953552A (en) 1989-04-21 1990-09-04 Demarzo Arthur P Blood glucose monitoring system
EP0396788A1 (en) 1989-05-08 1990-11-14 Dräger Nederland B.V. Process and sensor for measuring the glucose content of glucosecontaining fluids
FR2648353B1 (en) * 1989-06-16 1992-03-27 Europhor Sa Microdialysis probe
US5431160A (en) 1989-07-19 1995-07-11 University Of New Mexico Miniature implantable refillable glucose sensor and material therefor
US4986271A (en) * 1989-07-19 1991-01-22 The University Of New Mexico Vivo refillable glucose sensor
US5262035A (en) 1989-08-02 1993-11-16 E. Heller And Company Enzyme electrodes
US5264104A (en) 1989-08-02 1993-11-23 Gregg Brian A Enzyme electrodes
US5264105A (en) 1989-08-02 1993-11-23 Gregg Brian A Enzyme electrodes
US5320725A (en) 1989-08-02 1994-06-14 E. Heller & Company Electrode and method for the detection of hydrogen peroxide
US5568400A (en) 1989-09-01 1996-10-22 Stark; Edward W. Multiplicative signal correction method and apparatus
US5050612A (en) 1989-09-12 1991-09-24 Matsumura Kenneth N Device for computer-assisted monitoring of the body
US5082550A (en) * 1989-12-11 1992-01-21 The United States Of America As Represented By The Department Of Energy Enzyme electrochemical sensor electrode and method of making it
US5342789A (en) 1989-12-14 1994-08-30 Sensor Technologies, Inc. Method and device for detecting and quantifying glucose in body fluids
US5051688A (en) 1989-12-20 1991-09-24 Rohm Co., Ltd. Crossed coil meter driving device having a plurality of input parameters
US5243696A (en) 1989-12-29 1993-09-07 General Signal Corporation Programmable electronic display for a chart recorder
US5165407A (en) 1990-04-19 1992-11-24 The University Of Kansas Implantable glucose sensor
GB9008922D0 (en) 1990-04-20 1990-06-20 Philips Electronic Associated Analytical instrument and method of calibrating an analytical instrument
US5202261A (en) 1990-07-19 1993-04-13 Miles Inc. Conductive sensors and their use in diagnostic assays
US5431921A (en) 1990-09-28 1995-07-11 Pfizer Inc Dispensing device containing a hydrophobic medium
US5251126A (en) 1990-10-29 1993-10-05 Miles Inc. Diabetes data analysis and interpretation method
WO1992010133A1 (en) * 1990-12-12 1992-06-25 Intelligent Medical Systems, Inc. Infrared thermometer utilizing calibration mapping
US5228449A (en) 1991-01-22 1993-07-20 Athanasios G. Christ System and method for detecting out-of-hospital cardiac emergencies and summoning emergency assistance
US5262305A (en) 1991-03-04 1993-11-16 E. Heller & Company Interferant eliminating biosensors
CA2050057A1 (en) 1991-03-04 1992-09-05 Adam Heller Interferant eliminating biosensors
US5593852A (en) 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
US5632272A (en) 1991-03-07 1997-05-27 Masimo Corporation Signal processing apparatus
US5469855A (en) 1991-03-08 1995-11-28 Exergen Corporation Continuous temperature monitor
US5135004A (en) 1991-03-12 1992-08-04 Incontrol, Inc. Implantable myocardial ischemia monitor and related method
US5204264A (en) 1991-03-14 1993-04-20 E. I. Du Pont De Nemours And Company Method for validation of calibration standards in an automatic chemical analyzer
US5122925A (en) 1991-04-22 1992-06-16 Control Products, Inc. Package for electronic components
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
GB9120144D0 (en) 1991-09-20 1991-11-06 Imperial College A dialysis electrode device
US5322063A (en) 1991-10-04 1994-06-21 Eli Lilly And Company Hydrophilic polyurethane membranes for electrochemical glucose sensors
US5372427A (en) 1991-12-19 1994-12-13 Texas Instruments Incorporated Temperature sensor
US5285792A (en) * 1992-01-10 1994-02-15 Physio-Control Corporation System for producing prioritized alarm messages in a medical instrument
US5246867A (en) 1992-01-17 1993-09-21 University Of Maryland At Baltimore Determination and quantification of saccharides by luminescence lifetimes and energy transfer
CA2129227A1 (en) 1992-01-31 1993-08-05 Christian Paul Valcke Method and apparatus for closed loop drug delivery
US5328927A (en) 1992-03-03 1994-07-12 Merck Sharpe & Dohme, Ltd. Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
FR2690622B1 (en) * 1992-04-29 1995-01-20 Chronotec pump system programmable portable infusion.
US5711001A (en) * 1992-05-08 1998-01-20 Motorola, Inc. Method and circuit for acquisition by a radio receiver
GB9211402D0 (en) 1992-05-29 1992-07-15 Univ Manchester Sensor devices
DK95792D0 (en) 1992-07-24 1992-07-24 Radiometer As Sensor for non-invasive, in vivo determination of an analyte and blodgennemstroemning
US5330634A (en) * 1992-08-28 1994-07-19 Via Medical Corporation Calibration solutions useful for analyses of biological fluids and methods employing same
US6283761B1 (en) 1992-09-08 2001-09-04 Raymond Anthony Joao Apparatus and method for processing and/or for providing healthcare information and/or healthcare-related information
WO1994010553A1 (en) * 1992-10-23 1994-05-11 Optex Biomedical, Inc. Fibre-optic probe for the measurement of fluid parameters
US5899855A (en) 1992-11-17 1999-05-04 Health Hero Network, Inc. Modular microprocessor-based health monitoring system
CA2103325C (en) 1992-11-23 2004-07-20 Kirk W. Johnson Techniques to improve the performance of electrochemical sensors
CA2149913A1 (en) 1992-11-24 1994-06-09 James David Keeler Method and apparatus for operating a neural network with missing and/or incomplete data
US5410326A (en) 1992-12-04 1995-04-25 Goldstein; Steven W. Programmable remote control device for interacting with a plurality of remotely controlled devices
US5299571A (en) * 1993-01-22 1994-04-05 Eli Lilly And Company Apparatus and method for implantation of sensors
EP0622626B1 (en) 1993-04-23 2002-03-06 Boehringer Mannheim Gmbh System for analysing the components of fluid samples
US5384547A (en) 1993-08-02 1995-01-24 Motorola, Inc. Apparatus and method for attenuating a multicarrier input signal of a linear device
DE4329898A1 (en) 1993-09-04 1995-04-06 Marcus Dr Besson Wireless medical diagnostic and monitoring equipment
US5438983A (en) 1993-09-13 1995-08-08 Hewlett-Packard Company Patient alarm detection using trend vector analysis
US5582184A (en) 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5791344A (en) 1993-11-19 1998-08-11 Alfred E. Mann Foundation For Scientific Research Patient monitoring system
US5497772A (en) * 1993-11-19 1996-03-12 Alfred E. Mann Foundation For Scientific Research Glucose monitoring system
DE4401400A1 (en) 1994-01-19 1995-07-20 Ernst Prof Dr Pfeiffer Method and apparatus for continuously monitoring the concentration of a metabolite
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
US5391250A (en) * 1994-03-15 1995-02-21 Minimed Inc. Method of fabricating thin film sensors
US5390671A (en) * 1994-03-15 1995-02-21 Minimed Inc. Transcutaneous sensor insertion set
WO1995027272A1 (en) 1994-04-04 1995-10-12 Motorola Inc. Method and apparatus for activating and accessing remote meter interface devices
US5609575A (en) * 1994-04-11 1997-03-11 Graseby Medical Limited Infusion pump and method with dose-rate calculation
US5569186A (en) 1994-04-25 1996-10-29 Minimed Inc. Closed loop infusion pump system with removable glucose sensor
DE4415896A1 (en) * 1994-05-05 1995-11-09 Boehringer Mannheim Gmbh Analysis system for monitoring the concentration of an analyte in the blood of a patient
US5472317A (en) 1994-06-03 1995-12-05 Minimed Inc. Mounting clip for a medication infusion pump
US5601435A (en) 1994-11-04 1997-02-11 Intercare Method and apparatus for interactively monitoring a physiological condition and for interactively providing health related information
US5919141A (en) 1994-11-15 1999-07-06 Life Sensing Instrument Company, Inc. Vital sign remote monitoring device
DE69600098T2 (en) 1995-02-04 1998-06-10 Baumann & Haldi Sa Individual device for measuring, processing and transmission of substantially physiological parameters
US5586553A (en) 1995-02-16 1996-12-24 Minimed Inc. Transcutaneous sensor insertion set
US5568806A (en) 1995-02-16 1996-10-29 Minimed Inc. Transcutaneous sensor insertion set
US5564434A (en) 1995-02-27 1996-10-15 Medtronic, Inc. Implantable capacitive absolute pressure and temperature sensor
US5752512A (en) 1995-05-10 1998-05-19 Massachusetts Institute Of Technology Apparatus and method for non-invasive blood analyte measurement
US5628310A (en) 1995-05-19 1997-05-13 Joseph R. Lakowicz Method and apparatus to perform trans-cutaneous analyte monitoring
US5995860A (en) 1995-07-06 1999-11-30 Thomas Jefferson University Implantable sensor and system for measurement and control of blood constituent levels
CA2259254C (en) * 1996-07-08 2008-02-19 Animas Corporation Implantable sensor and system for in vivo measurement and control of fluid constituent levels
US5555190A (en) 1995-07-12 1996-09-10 Micro Motion, Inc. Method and apparatus for adaptive line enhancement in Coriolis mass flow meter measurement
US7016713B2 (en) 1995-08-09 2006-03-21 Inlight Solutions, Inc. Non-invasive determination of direction and rate of change of an analyte
US5972199A (en) 1995-10-11 1999-10-26 E. Heller & Company Electrochemical analyte sensors using thermostable peroxidase
US5665222A (en) 1995-10-11 1997-09-09 E. Heller & Company Soybean peroxidase electrochemical sensor
US5748103A (en) 1995-11-13 1998-05-05 Vitalcom, Inc. Two-way TDMA telemetry system with power conservation features
US5711861A (en) * 1995-11-22 1998-01-27 Ward; W. Kenneth Device for monitoring changes in analyte concentration
FI960636A (en) 1996-02-12 1997-08-13 Nokia Mobile Phones Ltd A method for monitoring the patient's state of health
US5833603A (en) 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
DE19618597B4 (en) 1996-05-09 2005-07-21 Institut für Diabetestechnologie Gemeinnützige Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm A method for determining the concentration of tissue glucose
US5735285A (en) 1996-06-04 1998-04-07 Data Critical Corp. Method and hand-held apparatus for demodulating and viewing frequency modulated biomedical signals
JP4012252B2 (en) * 1996-06-18 2007-11-21 アルザ コーポレイション Apparatus for enhancing the transdermal delivery or sampling of an agent
JP3581218B2 (en) 1996-07-03 2004-10-27 株式会社東芝 Mobile communication terminal device with its mobile telephone and data terminal equipment
US6544193B2 (en) 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
US6071251A (en) 1996-12-06 2000-06-06 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
US5964993A (en) 1996-12-19 1999-10-12 Implanted Biosystems Inc. Glucose sensor
US5914026A (en) 1997-01-06 1999-06-22 Implanted Biosystems Inc. Implantable sensor employing an auxiliary electrode
US5956501A (en) * 1997-01-10 1999-09-21 Health Hero Network, Inc. Disease simulation system and method
US6122351A (en) 1997-01-21 2000-09-19 Med Graph, Inc. Method and system aiding medical diagnosis and treatment
US6607509B2 (en) 1997-12-31 2003-08-19 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
CA2575064C (en) 1997-12-31 2010-02-02 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
US6093172A (en) 1997-02-05 2000-07-25 Minimed Inc. Injector for a subcutaneous insertion set
JP3394262B2 (en) * 1997-02-06 2003-04-07 イー.ヘラー アンド カンパニー Small volume in vitro analyte sensor
US5980708A (en) * 1997-02-12 1999-11-09 Champagne; Gilles Y. High sensitivity multiple waveform voltammetric instrument
US6309884B1 (en) 1997-02-26 2001-10-30 Diasense, Inc. Individual calibration of blood glucose for supporting noninvasive self-monitoring blood glucose
US6159147A (en) 1997-02-28 2000-12-12 Qrs Diagnostics, Llc Personal computer card for collection of real-time biological data
US7899511B2 (en) 1997-03-04 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
US6558321B1 (en) 1997-03-04 2003-05-06 Dexcom, Inc. Systems and methods for remote monitoring and modulation of medical devices
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US20050033132A1 (en) 1997-03-04 2005-02-10 Shults Mark C. Analyte measuring device
US6862465B2 (en) * 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US6741877B1 (en) 1997-03-04 2004-05-25 Dexcom, Inc. Device and method for determining analyte levels
US6699187B2 (en) 1997-03-27 2004-03-02 Medtronic, Inc. System and method for providing remote expert communications and video capabilities for use during a medical procedure
US6270455B1 (en) 1997-03-28 2001-08-07 Health Hero Network, Inc. Networked system for interactive communications and remote monitoring of drug delivery
US5961451A (en) 1997-04-07 1999-10-05 Motorola, Inc. Noninvasive apparatus having a retaining member to retain a removable biosensor
US5942979A (en) 1997-04-07 1999-08-24 Luppino; Richard On guard vehicle safety warning system
US5935224A (en) 1997-04-24 1999-08-10 Microsoft Corporation Method and apparatus for adaptively coupling an external peripheral device to either a universal serial bus port on a computer or hub or a game port on a computer
US7806886B2 (en) 1999-06-03 2010-10-05 Medtronic Minimed, Inc. Apparatus and method for controlling insulin infusion with state variable feedback
US5954643A (en) 1997-06-09 1999-09-21 Minimid Inc. Insertion set for a transcutaneous sensor
CA2294610A1 (en) 1997-06-16 1998-12-23 George Moshe Katz Methods of calibrating and testing a sensor for in vivo measurement of an analyte and devices for use in such methods
US6056435A (en) 1997-06-24 2000-05-02 Exergen Corporation Ambient and perfusion normalized temperature detector
US6066243A (en) 1997-07-22 2000-05-23 Diametrics Medical, Inc. Portable immediate response medical analyzer having multiple testing modules
US6259937B1 (en) 1997-09-12 2001-07-10 Alfred E. Mann Foundation Implantable substrate sensor
DE19836401A1 (en) 1997-09-19 2000-02-17 Salcomp Oy Salo An apparatus for charging rechargeable batteries
US6117290A (en) 1997-09-26 2000-09-12 Pepex Biomedical, Llc System and method for measuring a bioanalyte such as lactate
US5904671A (en) 1997-10-03 1999-05-18 Navot; Nir Tampon wetness detection system
US6119028A (en) 1997-10-20 2000-09-12 Alfred E. Mann Foundation Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces
US6088608A (en) 1997-10-20 2000-07-11 Alfred E. Mann Foundation Electrochemical sensor and integrity tests therefor
FI107080B (en) 1997-10-27 2001-05-31 Nokia Mobile Phones Ltd Measuring Instruments
ES2281143T3 (en) * 1997-11-12 2007-09-16 Lightouch Medical, Inc. Method for non-invasive measurement of an analyte.
US6579690B1 (en) 1997-12-05 2003-06-17 Therasense, Inc. Blood analyte monitoring through subcutaneous measurement
US7494816B2 (en) * 1997-12-22 2009-02-24 Roche Diagnostic Operations, Inc. System and method for determining a temperature during analyte measurement
US6103033A (en) 1998-03-04 2000-08-15 Therasense, Inc. Process for producing an electrochemical biosensor
US6134461A (en) * 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US6024699A (en) * 1998-03-13 2000-02-15 Healthware Corporation Systems, methods and computer program products for monitoring, diagnosing and treating medical conditions of remotely located patients
US6721582B2 (en) 1999-04-06 2004-04-13 Argose, Inc. Non-invasive tissue glucose level monitoring
JPH11296598A (en) 1998-04-07 1999-10-29 Seizaburo Arita System and method for predicting blood-sugar level and record medium where same method is recorded
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) * 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
DE69914319D1 (en) 1998-05-13 2004-02-26 Cygnus Therapeutic Systems Signal processing for measurement of physiological analytes
DE69910003D1 (en) 1998-05-13 2003-09-04 Cygnus Therapeutic Systems Monitoring physiological analytes
US6121611A (en) 1998-05-20 2000-09-19 Molecular Imaging Corporation Force sensing probe for scanning probe microscopy
US6359270B1 (en) 1998-09-04 2002-03-19 Ncr Corporation Communications module mounting for domestic appliance
US6223283B1 (en) 1998-07-17 2001-04-24 Compaq Computer Corporation Method and apparatus for identifying display monitor functionality and compatibility
US6493069B1 (en) 1998-07-24 2002-12-10 Terumo Kabushiki Kaisha Method and instrument for measuring blood sugar level
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
KR20000019716A (en) 1998-09-15 2000-04-15 박호군 Composition comprising bioflavonoid compounds for descending blood sugar
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6254586B1 (en) 1998-09-25 2001-07-03 Minimed Inc. Method and kit for supplying a fluid to a subcutaneous placement site
EP1102559B1 (en) * 1998-09-30 2003-06-04 Cygnus, Inc. Method and device for predicting physiological values
US6402689B1 (en) 1998-09-30 2002-06-11 Sicel Technologies, Inc. Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
JP4469504B2 (en) 1998-10-08 2010-05-26 メドトロニック ミニメド インコーポレイテッド Remote plasma monitor system
US6730025B1 (en) 1998-11-03 2004-05-04 Harry Louis Platt Hand held physiological signal acquisition device
US6602469B1 (en) 1998-11-09 2003-08-05 Lifestream Technologies, Inc. Health monitoring and diagnostic device and network-based health assessment and medical records maintenance system
WO2000030532A1 (en) * 1998-11-20 2000-06-02 University Of Connecticut Generic integrated implantable potentiostat telemetry unit for electrochemical sensors
DK1144028T3 (en) 1998-11-30 2004-10-18 Novo Nordisk As System to help a user during medical self treatment, said self treatment comprising a plurality of actions
US7436511B2 (en) 1999-01-22 2008-10-14 Sensys Medical, Inc. Analyte filter method and apparatus
US6248067B1 (en) 1999-02-05 2001-06-19 Minimed Inc. Analyte sensor and holter-type monitor system and method of using the same
JP2002536103A (en) 1999-02-12 2002-10-29 シグナス, インコーポレイテッド Devices and methods for frequent measurements of analyte present in a biological system
CA2362814A1 (en) 1999-02-18 2000-08-24 Biovalve Technologies, Inc. Electroactive pore
US6360888B1 (en) * 1999-02-25 2002-03-26 Minimed Inc. Glucose sensor package system
US6424847B1 (en) 1999-02-25 2002-07-23 Medtronic Minimed, Inc. Glucose monitor calibration methods
US6895263B2 (en) 2000-02-23 2005-05-17 Medtronic Minimed, Inc. Real time self-adjusting calibration algorithm
US7890295B2 (en) 2000-02-23 2011-02-15 Medtronic Minimed, Inc. Real time self-adjusting calibration algorithm
GB9907815D0 (en) 1999-04-06 1999-06-02 Univ Cambridge Tech Implantable sensor
US6285897B1 (en) * 1999-04-07 2001-09-04 Endonetics, Inc. Remote physiological monitoring system
US6200265B1 (en) * 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
US6669663B1 (en) 1999-04-30 2003-12-30 Medtronic, Inc. Closed loop medicament pump
US6359444B1 (en) 1999-05-28 2002-03-19 University Of Kentucky Research Foundation Remote resonant-circuit analyte sensing apparatus with sensing structure and associated method of sensing
US6546268B1 (en) 1999-06-02 2003-04-08 Ball Semiconductor, Inc. Glucose sensor
US7267665B2 (en) 1999-06-03 2007-09-11 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
US6558351B1 (en) 1999-06-03 2003-05-06 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
DE19925910B4 (en) 1999-06-07 2005-04-28 Siemens Ag A method for working or processing data
JP2003505754A (en) 1999-06-10 2003-02-12 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ How to identify effective signal in the measurement signal
US6423035B1 (en) 1999-06-18 2002-07-23 Animas Corporation Infusion pump with a sealed drive mechanism and improved method of occlusion detection
WO2000078992A3 (en) 1999-06-18 2001-07-19 Therasense Inc Mass transport limited in vivo analyte sensor
US6471689B1 (en) 1999-08-16 2002-10-29 Thomas Jefferson University Implantable drug delivery catheter system with capillary interface
US6923763B1 (en) 1999-08-23 2005-08-02 University Of Virginia Patent Foundation Method and apparatus for predicting the risk of hypoglycemia
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US6343225B1 (en) 1999-09-14 2002-01-29 Implanted Biosystems, Inc. Implantable glucose sensor
EP1211976A1 (en) 1999-09-17 2002-06-12 Thomas Pieber Device for conducting in vivo measurements of quantities in living organisms
US6790178B1 (en) 1999-09-24 2004-09-14 Healthetech, Inc. Physiological monitor and associated computation, display and communication unit
US7317938B2 (en) 1999-10-08 2008-01-08 Sensys Medical, Inc. Method of adapting in-vitro models to aid in noninvasive glucose determination
WO2001028495A3 (en) 1999-10-08 2002-07-11 Healthetech Inc Indirect calorimeter for weight control
US6616819B1 (en) 1999-11-04 2003-09-09 Therasense, Inc. Small volume in vitro analyte sensor and methods
US20060091006A1 (en) 1999-11-04 2006-05-04 Yi Wang Analyte sensor with insertion monitor, and methods
DE60011286T2 (en) 1999-11-15 2005-07-14 Therasense, Inc., Alameda Transition metal complex compounds with a bidentate ligands containing an imidazole ring
US6291200B1 (en) 1999-11-17 2001-09-18 Agentase, Llc Enzyme-containing polymeric sensors
US6658396B1 (en) 1999-11-29 2003-12-02 Tang Sharon S Neural network drug dosage estimation
US7286894B1 (en) 2000-01-07 2007-10-23 Pasco Scientific Hand-held computer device and method for interactive data acquisition, analysis, annotation, and calibration
JP3449958B2 (en) 2000-01-18 2003-09-22 理想科学工業株式会社 Printing system, a printing method and stores the print program computer-readable recording medium
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US7369635B2 (en) 2000-01-21 2008-05-06 Medtronic Minimed, Inc. Rapid discrimination preambles and methods for using the same
CA2396749C (en) 2000-01-21 2011-07-19 Medical Research Group, Inc. Ambulatory medical apparatus and method having telemetry modifiable control software
EP1248660B1 (en) 2000-01-21 2012-04-11 Medtronic MiniMed, Inc. Microprocessor controlled ambulatory medical apparatus with hand held communication device
US6873268B2 (en) 2000-01-21 2005-03-29 Medtronic Minimed, Inc. Microprocessor controlled ambulatory medical apparatus with hand held communication device
US7003336B2 (en) * 2000-02-10 2006-02-21 Medtronic Minimed, Inc. Analyte sensor method of making the same
US20030060765A1 (en) 2000-02-16 2003-03-27 Arthur Campbell Infusion device menu structure and method of using the same
US7027931B1 (en) 2000-02-24 2006-04-11 Bionostics, Inc. System for statistical analysis of quality control data
US7025425B2 (en) 2000-03-29 2006-04-11 University Of Virginia Patent Foundation Method, system, and computer program product for the evaluation of glycemic control in diabetes from self-monitoring data
US6610012B2 (en) 2000-04-10 2003-08-26 Healthetech, Inc. System and method for remote pregnancy monitoring
US6440068B1 (en) 2000-04-28 2002-08-27 International Business Machines Corporation Measuring user health as measured by multiple diverse health measurement devices utilizing a personal storage device
WO2001088524A1 (en) 2000-05-12 2001-11-22 Therasense, Inc. Electrodes with multilayer membranes and methods of using and making the electrodes
US7769420B2 (en) 2000-05-15 2010-08-03 Silver James H Sensors for detecting substances indicative of stroke, ischemia, or myocardial infarction
US7181261B2 (en) 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
US6442413B1 (en) 2000-05-15 2002-08-27 James H. Silver Implantable sensor
US7395158B2 (en) 2000-05-30 2008-07-01 Sensys Medical, Inc. Method of screening for disorders of glucose metabolism
US20040197846A1 (en) 2001-01-18 2004-10-07 Linda Hockersmith Determination of glucose sensitivity and a method to manipulate blood glucose concentration
US20040142403A1 (en) 2001-08-13 2004-07-22 Donald Hetzel Method of screening for disorders of glucose metabolism
CN100464557C (en) 2000-05-31 2009-02-25 爱科来株式会社 Remote data management system and measuring data gathering method
WO2002000111A1 (en) 2000-06-23 2002-01-03 Bodymedia, Inc. System for monitoring health, wellness and fitness
US6591125B1 (en) 2000-06-27 2003-07-08 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
US20030208113A1 (en) 2001-07-18 2003-11-06 Mault James R Closed loop glycemic index system
WO2002017210A3 (en) 2000-08-18 2003-03-27 Cygnus Therapeutic Systems Formulation and manipulation of databases of analyte and associated values
EP1309271B1 (en) 2000-08-18 2008-04-16 Animas Technologies LLC Device for prediction of hypoglycemic events
US6675030B2 (en) 2000-08-21 2004-01-06 Euro-Celtique, S.A. Near infrared blood glucose monitoring system
WO2002024065A1 (en) 2000-09-22 2002-03-28 Knobbe, Lim & Buckingham Method and apparatus for real-time estimation and control of pysiological parameters
WO2002030264A3 (en) 2000-10-10 2003-07-17 Microchips Inc Microchip reservoir devices using wireless transmission of power and data
US6695860B1 (en) * 2000-11-13 2004-02-24 Isense Corp. Transcutaneous sensor insertion device
US7052483B2 (en) 2000-12-19 2006-05-30 Animas Corporation Transcutaneous inserter for low-profile infusion sets
US20020147135A1 (en) 2000-12-21 2002-10-10 Oliver Schnell Method and device for producing an adapted travel treatment plan for administering a medicine in the event of a long-haul journey
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US6666821B2 (en) 2001-01-08 2003-12-23 Medtronic, Inc. Sensor system
US6970529B2 (en) 2001-01-16 2005-11-29 International Business Machines Corporation Unified digital architecture
US6529752B2 (en) 2001-01-17 2003-03-04 David T. Krausman Sleep disorder breathing event counter
WO2002056751A3 (en) * 2001-01-22 2002-11-07 Roche Diagnostics Corp Lancet device having capillary action
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
CA2440799A1 (en) 2001-03-14 2002-09-19 Baxter International Inc. Internet based therapy management system
WO2002073559A3 (en) 2001-03-14 2003-03-06 Milton E Hamilton Tracking device
US6968294B2 (en) 2001-03-15 2005-11-22 Koninklijke Philips Electronics N.V. Automatic system for monitoring person requiring care and his/her caretaker
WO2002078512A8 (en) 2001-04-02 2004-12-02 Therasense Inc Blood glucose tracking apparatus and methods
US6574490B2 (en) 2001-04-11 2003-06-03 Rio Grande Medical Technologies, Inc. System for non-invasive measurement of glucose in humans
US6983176B2 (en) 2001-04-11 2006-01-03 Rio Grande Medical Technologies, Inc. Optically similar reference samples and related methods for multivariate calibration models used in optical spectroscopy
US7161484B2 (en) 2001-04-17 2007-01-09 Micrel Medical Devices S.A. System for monitoring medical parameters
US6698269B2 (en) 2001-04-27 2004-03-02 Oceana Sensor Technologies, Inc. Transducer in-situ testing apparatus and method
US7395214B2 (en) 2001-05-11 2008-07-01 Craig P Shillingburg Apparatus, device and method for prescribing, administering and monitoring a treatment regimen for a patient
US6676816B2 (en) 2001-05-11 2004-01-13 Therasense, Inc. Transition metal complexes with (pyridyl)imidazole ligands and sensors using said complexes
US6932894B2 (en) 2001-05-15 2005-08-23 Therasense, Inc. Biosensor membranes composed of polymers containing heterocyclic nitrogens
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US7179226B2 (en) 2001-06-21 2007-02-20 Animas Corporation System and method for managing diabetes
JP4278048B2 (en) 2001-06-22 2009-06-10 ネルコア ピューリタン ベネット アイルランド Analysis based on wavelet pulse oximetry signal
US7044911B2 (en) 2001-06-29 2006-05-16 Philometron, Inc. Gateway platform for biological monitoring and delivery of therapeutic compounds
US6754516B2 (en) 2001-07-19 2004-06-22 Nellcor Puritan Bennett Incorporated Nuisance alarm reductions in a physiological monitor
US20030032874A1 (en) * 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US6544212B2 (en) 2001-07-31 2003-04-08 Roche Diagnostics Corporation Diabetes management system
US20040260478A1 (en) 2001-08-03 2004-12-23 Schwamm Lee H. System, process and diagnostic arrangement establishing and monitoring medication doses for patients
US6788965B2 (en) 2001-08-03 2004-09-07 Sensys Medical, Inc. Intelligent system for detecting errors and determining failure modes in noninvasive measurement of blood and tissue analytes
JP3775263B2 (en) 2001-08-10 2006-05-17 ニプロ株式会社 Recording medium and blood glucose monitoring system using the recording medium
US20040054263A1 (en) 2001-08-20 2004-03-18 Piet Moerman Wireless diabetes management devices and methods for using the same
WO2003019165A3 (en) 2001-08-22 2003-11-27 Instrumentation Lab Co Method and apparatus for calibrating electrochemical sensors
JP3962250B2 (en) 2001-08-29 2007-08-22 株式会社レアメタル Vivo information detection system and tag devices used in this relay device
US6827702B2 (en) 2001-09-07 2004-12-07 Medtronic Minimed, Inc. Safety limits for closed-loop infusion pump control
US6740072B2 (en) 2001-09-07 2004-05-25 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
US7052591B2 (en) 2001-09-21 2006-05-30 Therasense, Inc. Electrodeposition of redox polymers and co-electrodeposition of enzymes by coordinative crosslinking
US6830562B2 (en) 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
US20050137480A1 (en) 2001-10-01 2005-06-23 Eckhard Alt Remote control of implantable device through medical implant communication service band
DE60237463D1 (en) 2001-11-16 2010-10-07 Roche Diagnostics Gmbh Flexible sensor and manufacturing processes
WO2003049424A1 (en) 2001-12-03 2003-06-12 Nikon Corporation Electronic apparatus, electronic camera, electronic device, image display apparatus, and image transmission system
US7204823B2 (en) 2001-12-19 2007-04-17 Medtronic Minimed, Inc. Medication delivery system and monitor
US7729776B2 (en) 2001-12-19 2010-06-01 Cardiac Pacemakers, Inc. Implantable medical device with two or more telemetry systems
US7399277B2 (en) 2001-12-27 2008-07-15 Medtronic Minimed, Inc. System for monitoring physiological characteristics
US20050027182A1 (en) 2001-12-27 2005-02-03 Uzair Siddiqui System for monitoring physiological characteristics
US7022072B2 (en) 2001-12-27 2006-04-04 Medtronic Minimed, Inc. System for monitoring physiological characteristics
US6980852B2 (en) 2002-01-25 2005-12-27 Subqiview Inc. Film barrier dressing for intravascular tissue monitoring system
US20030212379A1 (en) 2002-02-26 2003-11-13 Bylund Adam David Systems and methods for remotely controlling medication infusion and analyte monitoring
EP1487519B1 (en) 2002-02-26 2013-06-12 TecPharma Licensing AG Insertion device for an insertion set and method of using the same
US6936006B2 (en) 2002-03-22 2005-08-30 Novo Nordisk, A/S Atraumatic insertion of a subcutaneous device
GB2388898B (en) 2002-04-02 2005-10-05 Inverness Medical Ltd Integrated sample testing meter
US7027848B2 (en) 2002-04-04 2006-04-11 Inlight Solutions, Inc. Apparatus and method for non-invasive spectroscopic measurement of analytes in tissue using a matched reference analyte
US7153265B2 (en) 2002-04-22 2006-12-26 Medtronic Minimed, Inc. Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance
EP1498067A1 (en) 2002-04-25 2005-01-19 Matsushita Electric Industrial Co., Ltd. Dosage determination supporting device, injector, and health management supporting system
GB2388716B (en) 2002-05-13 2004-10-20 Splashpower Ltd Improvements relating to contact-less power transfer
US7015817B2 (en) 2002-05-14 2006-03-21 Shuan Michael Copley Personal tracking device
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7226978B2 (en) 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US6865407B2 (en) 2002-07-11 2005-03-08 Optical Sensors, Inc. Calibration technique for non-invasive medical devices
US20040010207A1 (en) * 2002-07-15 2004-01-15 Flaherty J. Christopher Self-contained, automatic transcutaneous physiologic sensing system
JP2004054394A (en) 2002-07-17 2004-02-19 Toshiba Corp Radio information processing system, radio information recording medium, radio information processor and communication method for radio information processing system
US7034677B2 (en) 2002-07-19 2006-04-25 Smiths Detection Inc. Non-specific sensor array detectors
US20070100222A1 (en) 2004-06-14 2007-05-03 Metronic Minimed, Inc. Analyte sensing apparatus for hospital use
US7278983B2 (en) 2002-07-24 2007-10-09 Medtronic Minimed, Inc. Physiological monitoring device for controlling a medication infusion device
EP2327359B1 (en) 2002-08-13 2015-01-21 University Of Virginia Patent Foundation Method, system, and computer program product for processing of self-monitoring blood glucose (smbg) data to enhance diabetic self-management
DK1734858T3 (en) 2004-03-22 2014-10-20 Bodymedia Inc Non-invasive temperature monitoring device
US7192405B2 (en) * 2002-09-30 2007-03-20 Becton, Dickinson And Company Integrated lancet and bodily fluid sensor
US20090177068A1 (en) 2002-10-09 2009-07-09 Stivoric John M Method and apparatus for providing derived glucose information utilizing physiological and/or contextual parameters
DE60328039D1 (en) 2002-10-11 2009-07-30 Becton Dickinson Co Insulin delivery system with sensor
EP1565102A4 (en) 2002-10-15 2008-05-28 Medtronic Inc Synchronization and calibration of clocks for a medical device and calibrated clock
US7381184B2 (en) 2002-11-05 2008-06-03 Abbott Diabetes Care Inc. Sensor inserter assembly
US7572237B2 (en) 2002-11-06 2009-08-11 Abbott Diabetes Care Inc. Automatic biological analyte testing meter with integrated lancing device and methods of use
GB0226648D0 (en) 2002-11-15 2002-12-24 Koninkl Philips Electronics Nv Usage data harvesting
EP1424637A1 (en) 2002-11-29 2004-06-02 Instrumentarium Corporation Artifact removal from an electric signal
US7009511B2 (en) 2002-12-17 2006-03-07 Cardiac Pacemakers, Inc. Repeater device for communications with an implantable medical device
US20040122353A1 (en) 2002-12-19 2004-06-24 Medtronic Minimed, Inc. Relay device for transferring information between a sensor system and a fluid delivery system
US7811231B2 (en) 2002-12-31 2010-10-12 Abbott Diabetes Care Inc. Continuous glucose monitoring system and methods of use
US7413749B2 (en) 2003-03-11 2008-08-19 Purdue Pharma L.P. Titration dosing regimen for controlled release tramadol
WO2004084820A3 (en) 2003-03-19 2007-05-03 Paul C Davidson Method and system for determining insulin dosing schedules and carbohydrate-to-insulin ratios in diabetic patients
US20040199056A1 (en) 2003-04-03 2004-10-07 International Business Machines Corporation Body monitoring using local area wireless interfaces
US7134999B2 (en) 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
US20040204868A1 (en) 2003-04-09 2004-10-14 Maynard John D. Reduction of errors in non-invasive tissue sampling
US20050022274A1 (en) 2003-04-18 2005-01-27 Robert Campbell User interface for infusion pump remote controller and method of using the same
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US7875293B2 (en) * 2003-05-21 2011-01-25 Dexcom, Inc. Biointerface membranes incorporating bioactive agents
US7192450B2 (en) * 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US7258673B2 (en) 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
US8460243B2 (en) 2003-06-10 2013-06-11 Abbott Diabetes Care Inc. Glucose measuring module and insulin pump combination
US20040254433A1 (en) 2003-06-12 2004-12-16 Bandis Steven D. Sensor introducer system, apparatus and method
US7155290B2 (en) 2003-06-23 2006-12-26 Cardiac Pacemakers, Inc. Secure long-range telemetry for implantable medical device
US7510564B2 (en) 2003-06-27 2009-03-31 Abbott Diabetes Care Inc. Lancing device
US7722536B2 (en) 2003-07-15 2010-05-25 Abbott Diabetes Care Inc. Glucose measuring device integrated into a holster for a personal area network device
WO2005007223A3 (en) 2003-07-16 2005-09-22 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
WO2005010756A8 (en) 2003-07-25 2006-04-06 Philips Intellectual Property Method and device for monitoring a system
US7108778B2 (en) 2003-07-25 2006-09-19 Dexcom, Inc. Electrochemical sensors including electrode systems with increased oxygen generation
EP1649260A4 (en) 2003-07-25 2010-07-07 Dexcom Inc Electrode systems for electrochemical sensors
WO2005011520A3 (en) 2003-07-25 2005-12-15 Dexcom Inc Oxygen enhancing membrane systems for implantable devices
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US8626257B2 (en) 2003-08-01 2014-01-07 Dexcom, Inc. Analyte sensor
US7933639B2 (en) 2003-08-01 2011-04-26 Dexcom, Inc. System and methods for processing analyte sensor data
US8845536B2 (en) 2003-08-01 2014-09-30 Dexcom, Inc. Transcutaneous analyte sensor
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US6954662B2 (en) 2003-08-19 2005-10-11 A.D. Integrity Applications, Ltd. Method of monitoring glucose level
US8233959B2 (en) 2003-08-22 2012-07-31 Dexcom, Inc. Systems and methods for processing analyte sensor data
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
DE10343863A1 (en) 2003-09-23 2005-04-14 Roche Diagnostics Gmbh Method and apparatus for continuously monitoring the concentration of an analyte
JP3612324B1 (en) 2003-09-29 2005-01-19 株式会社日立製作所 Blood glucose level display method and apparatus
CA2541616A1 (en) 2003-09-30 2005-04-14 Andre Mang Sensor with increased biocompatibility
US20050090607A1 (en) 2003-10-28 2005-04-28 Dexcom, Inc. Silicone composition for biocompatible membrane
WO2005040404A1 (en) * 2003-10-29 2005-05-06 Agency For Science, Technology And Research Biosensor
JP2007512588A (en) 2003-10-29 2007-05-17 ノボ・ノルデイスク・エー/エス Medical advisory system
US6928380B2 (en) 2003-10-30 2005-08-09 International Business Machines Corporation Thermal measurements of electronic devices during operation
US20050096516A1 (en) 2003-10-30 2005-05-05 Orhan Soykan Optical detector of organic analyte
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
US20090012376A1 (en) 2003-11-03 2009-01-08 Children's Medical Center Corporation Continuous Analyte Monitor and Method of Using Same
US7519408B2 (en) 2003-11-19 2009-04-14 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US20050176136A1 (en) 2003-11-19 2005-08-11 Dexcom, Inc. Afinity domain for analyte sensor
US20050113886A1 (en) 2003-11-24 2005-05-26 Fischell David R. Implantable medical system with long range telemetry
KR100519776B1 (en) 2003-11-24 2005-10-07 삼성전자주식회사 Method and apparatus for converting resolution of video signal
US20050113648A1 (en) 2003-11-24 2005-05-26 Soohyun Yang Bidirectional monitoring system capable of a medical diagnosis and a commercial broadcast
US7366556B2 (en) 2003-12-05 2008-04-29 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7467003B2 (en) 2003-12-05 2008-12-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US20080197024A1 (en) 2003-12-05 2008-08-21 Dexcom, Inc. Analyte sensor
EP2239567B1 (en) 2003-12-05 2015-09-02 DexCom, Inc. Calibration techniques for a continuous analyte sensor
US7460898B2 (en) 2003-12-05 2008-12-02 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8425417B2 (en) 2003-12-05 2013-04-23 Dexcom, Inc. Integrated device for continuous in vivo analyte detection and simultaneous control of an infusion device
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8287453B2 (en) 2003-12-05 2012-10-16 Dexcom, Inc. Analyte sensor
US7424318B2 (en) 2003-12-05 2008-09-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7831287B2 (en) 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7081195B2 (en) 2003-12-08 2006-07-25 Dexcom, Inc. Systems and methods for improving electrochemical analyte sensors
EP1711791B1 (en) 2003-12-09 2014-10-15 DexCom, Inc. Signal processing for continuous analyte sensor
GB0400339D0 (en) 2004-01-08 2004-02-11 Remote Diagnostic Technologies Medical monitoring apparatus
US7637868B2 (en) 2004-01-12 2009-12-29 Dexcom, Inc. Composite material for implantable device
EP2843848B1 (en) 2004-01-27 2017-11-01 Altivera L.L.C. Diagnostic radio frequency identification sensors and applications thereof
US7580812B2 (en) 2004-01-28 2009-08-25 Honeywell International Inc. Trending system and method using window filtering
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US7364592B2 (en) 2004-02-12 2008-04-29 Dexcom, Inc. Biointerface membrane with macro-and micro-architecture
US20070060979A1 (en) 2004-06-10 2007-03-15 Ndi Medical, Llc Implantable pulse generator systems and methods for providing functional and / or therapeutic stimulation of muscles and / or nerves and / or central nervous system tissue
US8771183B2 (en) 2004-02-17 2014-07-08 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
US20060154642A1 (en) 2004-02-20 2006-07-13 Scannell Robert F Jr Medication & health, environmental, and security monitoring, alert, intervention, information and network system with associated and supporting apparatuses
JP3590053B1 (en) 2004-02-24 2004-11-17 株式会社日立製作所 Blood glucose level measuring device
RU2345705C2 (en) 2004-02-26 2009-02-10 Диабетес Тулз Сведен Аб Metabolic control, method and device for obtaining indications about health-determining state of examined person
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US7404796B2 (en) 2004-03-01 2008-07-29 Becton Dickinson And Company System for determining insulin dose using carbohydrate to insulin ratio and insulin sensitivity factor
US7039538B2 (en) 2004-03-08 2006-05-02 Nellcor Puritant Bennett Incorporated Pulse oximeter with separate ensemble averaging for oxygen saturation and heart rate
US7831828B2 (en) 2004-03-15 2010-11-09 Cardiac Pacemakers, Inc. System and method for securely authenticating a data exchange session with an implantable medical device
EP1735729A2 (en) 2004-03-26 2006-12-27 Novo Nordisk A/S Device for displaying data relevant for a diabetic patient
US6971274B2 (en) 2004-04-02 2005-12-06 Sierra Instruments, Inc. Immersible thermal mass flow meter
WO2005106017A3 (en) 2004-04-21 2007-08-02 William L Clarke Method, system and computer program product for evaluating the accuracy of blood glucose monitoring sensors/devices
US7657297B2 (en) 2004-05-03 2010-02-02 Dexcom, Inc. Implantable analyte sensor
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US20050245799A1 (en) 2004-05-03 2005-11-03 Dexcom, Inc. Implantable analyte sensor
WO2005113036A1 (en) 2004-05-13 2005-12-01 The Regents Of The University Of California Method and apparatus for glucose control and insulin dosing for diabetics
US6999854B2 (en) 2004-05-28 2006-02-14 International Business Machines Corporation Medical infusion pump capable of learning bolus time patterns and providing bolus alerts
US7118667B2 (en) 2004-06-02 2006-10-10 Jin Po Lee Biosensors having improved sample application and uses thereof
WO2005119524A3 (en) 2004-06-04 2007-04-19 Therasense Inc Diabetes care host-client architecture and data management system
US7289855B2 (en) 2004-06-09 2007-10-30 Medtronic, Inc. Implantable medical device package antenna
WO2006022993A3 (en) 2004-06-10 2006-12-21 Ndi Medical Llc Implantable generator for muscle and nerve stimulation
US7623988B2 (en) 2004-06-23 2009-11-24 Cybiocare Inc. Method and apparatus for the monitoring of clinical states
DE102004031092A1 (en) 2004-06-28 2006-01-12 Giesecke & Devrient Gmbh transponder unit
US20060001538A1 (en) * 2004-06-30 2006-01-05 Ulrich Kraft Methods of monitoring the concentration of an analyte
US20060001551A1 (en) 2004-06-30 2006-01-05 Ulrich Kraft Analyte monitoring system with wireless alarm
US20060015020A1 (en) * 2004-07-06 2006-01-19 Dexcom, Inc. Systems and methods for manufacture of an analyte-measuring device including a membrane system
US20080242961A1 (en) 2004-07-13 2008-10-02 Dexcom, Inc. Transcutaneous analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US20060270922A1 (en) 2004-07-13 2006-11-30 Brauker James H Analyte sensor
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US7783333B2 (en) * 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US7344500B2 (en) 2004-07-27 2008-03-18 Medtronic Minimed, Inc. Sensing system with auxiliary display
US8313433B2 (en) 2004-08-06 2012-11-20 Medtronic Minimed, Inc. Medical data management system and process
WO2006026741A1 (en) 2004-08-31 2006-03-09 Lifescan Scotland Limited Wearable sensor device and system
US7214189B2 (en) 2004-09-02 2007-05-08 Proteus Biomedical, Inc. Methods and apparatus for tissue activation and monitoring
WO2006024671A1 (en) 2004-09-03 2006-03-09 Novo Nordisk A/S A method of calibrating a system for measuring the concentration of substances in body and an apparatus for exercising the method
US7468033B2 (en) 2004-09-08 2008-12-23 Medtronic Minimed, Inc. Blood contacting sensor
US20090247931A1 (en) 2004-09-23 2009-10-01 Novo Nordisk A/S Device for self-care support
JP5049132B2 (en) 2004-11-15 2012-10-17 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Mobile medical telemetry device having a voice indicator
US7237712B2 (en) 2004-12-01 2007-07-03 Alfred E. Mann Foundation For Scientific Research Implantable device and communication integrated circuit implementable therein
US20070010950A1 (en) 2004-12-03 2007-01-11 Abensour Daniel S Method to determine the degree and stability of blood glucose control in patients with diabetes mellitus via the creation and continuous update of new statistical indicators in blood glucose monitors or free standing computers
EP1827214B1 (en) 2004-12-13 2012-02-15 Koninklijke Philips Electronics N.V. Mobile monitoring
US20090082693A1 (en) 2004-12-29 2009-03-26 Therasense, Inc. Method and apparatus for providing temperature sensor module in a data communication system
US20060166629A1 (en) 2005-01-24 2006-07-27 Therasense, Inc. Method and apparatus for providing EMC Class-B compliant RF transmitter for data monitoring an detection systems
US20060173260A1 (en) 2005-01-31 2006-08-03 Gmms Ltd System, device and method for diabetes treatment and monitoring
US7547281B2 (en) 2005-02-01 2009-06-16 Medtronic Minimed, Inc. Algorithm sensor augmented bolus estimator for semi-closed loop infusion system
WO2006085087A3 (en) 2005-02-11 2006-12-07 Jonathan Mark Cooper Sensing device, apparatus and system, and method for operating the same
US7390663B2 (en) 2005-02-23 2008-06-24 Streck, Inc. Process, composition and kit for providing a stable whole blood calibrator/control
KR100638727B1 (en) 2005-02-28 2006-10-30 삼성전기주식회사 Concurrent transceiver for zigbee and bluetooth
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20060202805A1 (en) 2005-03-14 2006-09-14 Alfred E. Mann Foundation For Scientific Research Wireless acquisition and monitoring system
EP1859279A4 (en) 2005-03-15 2009-12-30 Entelos Inc Apparatus and method for computer modeling type 1 diabetes
EP1863559A4 (en) 2005-03-21 2008-07-30 Abbott Diabetes Care Inc Method and system for providing integrated medication infusion and analyte monitoring system
US7889069B2 (en) 2005-04-01 2011-02-15 Codman & Shurtleff, Inc. Wireless patient monitoring system
US7651596B2 (en) 2005-04-08 2010-01-26 Dexcom, Inc. Cellulosic-based interference domain for an analyte sensor
US20070173710A1 (en) 2005-04-08 2007-07-26 Petisce James R Membranes for an analyte sensor
GB2425601B (en) 2005-04-26 2008-01-30 Bio Nano Sensium Technologies Sensor configuration
US20060247985A1 (en) 2005-04-29 2006-11-02 Therasense, Inc. Method and system for monitoring consumable item usage and providing replenishment thereof
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US7635594B2 (en) 2005-05-09 2009-12-22 Theranos, Inc. Point-of-care fluidic systems and uses thereof
US7806854B2 (en) 2005-05-13 2010-10-05 Trustees Of Boston University Fully automated control system for type 1 diabetes
WO2006130854A3 (en) 2005-06-02 2007-11-15 Isense Corp Use of multiple data points and filtering in an analyte sensor
US20060272652A1 (en) 2005-06-03 2006-12-07 Medtronic Minimed, Inc. Virtual patient software system for educating and treating individuals with diabetes
US20070033074A1 (en) 2005-06-03 2007-02-08 Medtronic Minimed, Inc. Therapy management system
CA2653616C (en) 2005-06-08 2013-02-12 Philip Michael Sher Fluctuating blood glucose notification threshold profiles and methods of use
US8251904B2 (en) 2005-06-09 2012-08-28 Roche Diagnostics Operations, Inc. Device and method for insulin dosing
WO2007007459A1 (en) 2005-07-12 2007-01-18 Omron Healthcare Co., Ltd. Biochemical measuring instrument for measuring information about component of living body accurately
US7413124B2 (en) 2005-07-19 2008-08-19 3M Innovative Properties Company RFID reader supporting one-touch search functionality
US20070066956A1 (en) 2005-07-27 2007-03-22 Medtronic Minimed, Inc. Systems and methods for entering temporary basal rate pattern in an infusion device
US20070027381A1 (en) * 2005-07-29 2007-02-01 Therasense, Inc. Inserter and methods of use
US7606784B2 (en) 2005-08-02 2009-10-20 Northrop Grumman Corporation Uncertainty management in a decision-making system
US20070093786A1 (en) 2005-08-16 2007-04-26 Medtronic Minimed, Inc. Watch controller for a medical device
US20090227855A1 (en) 2005-08-16 2009-09-10 Medtronic Minimed, Inc. Controller device for an infusion pump
US20070060869A1 (en) 2005-08-16 2007-03-15 Tolle Mike C V Controller device for an infusion pump
US7731657B2 (en) 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US8831735B2 (en) 2005-08-31 2014-09-09 Michael Sasha John Methods and systems for semi-automatic adjustment of medical monitoring and treatment
US9089713B2 (en) 2005-08-31 2015-07-28 Michael Sasha John Methods and systems for semi-automatic adjustment of medical monitoring and treatment
WO2007027691A1 (en) 2005-08-31 2007-03-08 University Of Virginia Patent Foundation Improving the accuracy of continuous glucose sensors
DK2260757T3 (en) 2005-09-09 2016-06-27 F Hoffmann-La Roche Ag System tools, apparatus and a program for diabetes treatment
US9072476B2 (en) * 2005-09-23 2015-07-07 Medtronic Minimed, Inc. Flexible sensor apparatus
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US9398882B2 (en) * 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US7756561B2 (en) 2005-09-30 2010-07-13 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US7883464B2 (en) 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US9521968B2 (en) 2005-09-30 2016-12-20 Abbott Diabetes Care Inc. Analyte sensor retention mechanism and methods of use
US7468125B2 (en) 2005-10-17 2008-12-23 Lifescan, Inc. System and method of processing a current sample for calculating a glucose concentration
CA2622986A1 (en) 2005-10-20 2007-04-26 Big Glucose Ltd. Non-invasive glucose monitoring
US20090054747A1 (en) 2005-10-31 2009-02-26 Abbott Diabetes Care, Inc. Method and system for providing analyte sensor tester isolation
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
EP1955240B8 (en) 2005-11-08 2016-03-30 Bigfoot Biomedical, Inc. Method for manual and autonomous control of an infusion pump
US20070173706A1 (en) 2005-11-11 2007-07-26 Isense Corporation Method and apparatus for insertion of a sensor
WO2007062173A1 (en) 2005-11-22 2007-05-31 Vocollect Healthcare Systems, Inc. Advanced diabetes management system (adms)
US7963917B2 (en) 2005-12-05 2011-06-21 Echo Therapeutics, Inc. System and method for continuous non-invasive glucose monitoring
US7941200B2 (en) 2005-12-08 2011-05-10 Roche Diagnostics Operations, Inc. System and method for determining drug administration information
US8515518B2 (en) 2005-12-28 2013-08-20 Abbott Diabetes Care Inc. Analyte monitoring
US8160670B2 (en) 2005-12-28 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring: stabilizer for subcutaneous glucose sensor with incorporated antiglycolytic agent
CA2636034A1 (en) 2005-12-28 2007-10-25 Abbott Diabetes Care Inc. Medical device insertion
US8102789B2 (en) 2005-12-29 2012-01-24 Medtronic, Inc. System and method for synchronous wireless communication with a medical device
US20070179349A1 (en) 2006-01-19 2007-08-02 Hoyme Kenneth P System and method for providing goal-oriented patient management based upon comparative population data analysis
US7736310B2 (en) 2006-01-30 2010-06-15 Abbott Diabetes Care Inc. On-body medical device securement
US7872574B2 (en) 2006-02-01 2011-01-18 Innovation Specialists, Llc Sensory enhancement systems and methods in personal electronic devices
WO2007095093A3 (en) 2006-02-09 2008-01-17 Deka Products Lp Pumping fluid delivery systems and methods using force application assembly
WO2007093981A3 (en) 2006-02-15 2007-10-04 Medingo Ltd Systems and methods for sensing analyte and dispensing therapeutic fluid
EP2407095A1 (en) 2006-02-22 2012-01-18 DexCom, Inc. Analyte sensor
CA2630550A1 (en) 2006-02-27 2007-09-07 Edwards Lifesciences Corporation Flux limiting membrane for intravenous amperometric biosensor
US7981034B2 (en) 2006-02-28 2011-07-19 Abbott Diabetes Care Inc. Smart messages and alerts for an infusion delivery and management system
US7826879B2 (en) 2006-02-28 2010-11-02 Abbott Diabetes Care Inc. Analyte sensors and methods of use
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
ES2336360T3 (en) 2006-04-20 2010-04-12 Lifescan Scotland Ltd Method for transmitting data in a system of blood glucose and glucose system corresponding blood.
US8380300B2 (en) 2006-04-28 2013-02-19 Medtronic, Inc. Efficacy visualization
US20070255126A1 (en) 2006-04-28 2007-11-01 Moberg Sheldon B Data communication in networked fluid infusion systems
WO2007128144A1 (en) 2006-05-10 2007-11-15 F. Hoffmann-La Roche Ag Infusion apparatus with a data storage device
US7496852B2 (en) 2006-05-16 2009-02-24 International Business Machines Corporation Graphically manipulating a database
US20080071157A1 (en) 2006-06-07 2008-03-20 Abbott Diabetes Care, Inc. Analyte monitoring system and method
US20080177149A1 (en) 2006-06-16 2008-07-24 Stefan Weinert System and method for collecting patient information from which diabetes therapy may be determined
US20070299617A1 (en) * 2006-06-27 2007-12-27 Willis John P Biofouling self-compensating biosensor
US20080004601A1 (en) 2006-06-28 2008-01-03 Abbott Diabetes Care, Inc. Analyte Monitoring and Therapy Management System and Methods Therefor
US9119582B2 (en) 2006-06-30 2015-09-01 Abbott Diabetes Care, Inc. Integrated analyte sensor and infusion device and methods therefor
US20090105571A1 (en) 2006-06-30 2009-04-23 Abbott Diabetes Care, Inc. Method and System for Providing Data Communication in Data Management Systems
EP2365453A3 (en) 2006-07-07 2014-09-10 Roche Diagnostics GmbH Fluid delivery device and methods of its operation
US8932216B2 (en) 2006-08-07 2015-01-13 Abbott Diabetes Care Inc. Method and system for providing data management in integrated analyte monitoring and infusion system
US20080058626A1 (en) 2006-09-05 2008-03-06 Shinichi Miyata Analytical meter with display-based tutorial module
US20080058678A1 (en) 2006-09-05 2008-03-06 Shinichi Miyata Kit for the determination of an analyte in a bodily fluid sample that includes a meter with a display-based tutorial module
US9056165B2 (en) 2006-09-06 2015-06-16 Medtronic Minimed, Inc. Intelligent therapy recommendation algorithm and method of using the same
US7618369B2 (en) 2006-10-02 2009-11-17 Abbott Diabetes Care Inc. Method and system for dynamically updating calibration parameters for an analyte sensor
US8364230B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US20080200788A1 (en) 2006-10-04 2008-08-21 Dexcorn, Inc. Analyte sensor
US8532730B2 (en) 2006-10-04 2013-09-10 Dexcom, Inc. Analyte sensor
US8449464B2 (en) 2006-10-04 2013-05-28 Dexcom, Inc. Analyte sensor
US8478377B2 (en) 2006-10-04 2013-07-02 Dexcom, Inc. Analyte sensor
US8425416B2 (en) 2006-10-04 2013-04-23 Dexcom, Inc. Analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8298142B2 (en) 2006-10-04 2012-10-30 Dexcom, Inc. Analyte sensor
US8447376B2 (en) 2006-10-04 2013-05-21 Dexcom, Inc. Analyte sensor
US8275438B2 (en) 2006-10-04 2012-09-25 Dexcom, Inc. Analyte sensor
US8562528B2 (en) 2006-10-04 2013-10-22 Dexcom, Inc. Analyte sensor
US8255026B1 (en) 2006-10-12 2012-08-28 Masimo Corporation, Inc. Patient monitor capable of monitoring the quality of attached probes and accessories
US20080092638A1 (en) 2006-10-19 2008-04-24 Bayer Healthcare Llc Wireless analyte monitoring system
JP2010508091A (en) 2006-10-26 2010-03-18 アボット ダイアベティス ケア インコーポレイテッドAbbott Diabetes Care Inc. The method for detecting a decrease sensitivity of the analyte sensor in real time systems, and computer program products
US8439837B2 (en) 2006-10-31 2013-05-14 Lifescan, Inc. Systems and methods for detecting hypoglycemic events having a reduced incidence of false alarms
US20080139910A1 (en) 2006-12-06 2008-06-12 Metronic Minimed, Inc. Analyte sensor and method of using the same
WO2008071218A1 (en) 2006-12-14 2008-06-19 Egomedical Swiss Ag Monitoring device
US20080154513A1 (en) 2006-12-21 2008-06-26 University Of Virginia Patent Foundation Systems, Methods and Computer Program Codes for Recognition of Patterns of Hyperglycemia and Hypoglycemia, Increased Glucose Variability, and Ineffective Self-Monitoring in Diabetes
US7946985B2 (en) 2006-12-29 2011-05-24 Medtronic Minimed, Inc. Method and system for providing sensor redundancy
US7734323B2 (en) 2007-01-24 2010-06-08 Smiths Medical Asd, Inc. Correction factor testing using frequent blood glucose input
US7742747B2 (en) 2007-01-25 2010-06-22 Icera Canada ULC Automatic IIP2 calibration architecture
US20080183060A1 (en) 2007-01-31 2008-07-31 Steil Garry M Model predictive method and system for controlling and supervising insulin infusion
US9597019B2 (en) 2007-02-09 2017-03-21 Lifescan, Inc. Method of ensuring date and time on a test meter is accurate
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
WO2008114254A1 (en) 2007-03-19 2008-09-25 Medingo Ltd. User interface for selecting bolus doses in a drug delivery device
US20080234943A1 (en) 2007-03-20 2008-09-25 Pinaki Ray Computer program for diabetes management
US9029157B2 (en) 2007-04-12 2015-05-12 Nipro Diagnostics, Inc. Error detection and rejection for a diagnostic testing system
EP2137637A4 (en) 2007-04-14 2012-06-20 Abbott Diabetes Care Inc Method and apparatus for providing data processing and control in medical communication system
US9204827B2 (en) 2007-04-14 2015-12-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
US9008743B2 (en) 2007-04-14 2015-04-14 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
WO2009096992A1 (en) 2007-04-14 2009-08-06 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in medical communication system
CA2683959C (en) 2007-04-14 2017-08-29 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
US20080269723A1 (en) 2007-04-25 2008-10-30 Medtronic Minimed, Inc. Closed loop/semi-closed loop therapy modification system
US20080269714A1 (en) 2007-04-25 2008-10-30 Medtronic Minimed, Inc. Closed loop/semi-closed loop therapy modification system
CA2685167A1 (en) 2007-05-14 2008-11-27 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US20090006034A1 (en) 2007-05-14 2009-01-01 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in a medical communication system
US20080312845A1 (en) 2007-05-14 2008-12-18 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in a medical communication system
US8140312B2 (en) 2007-05-14 2012-03-20 Abbott Diabetes Care Inc. Method and system for determining analyte levels
US8103471B2 (en) 2007-05-14 2012-01-24 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US9125548B2 (en) 2007-05-14 2015-09-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US20080294024A1 (en) 2007-05-24 2008-11-27 Cosentino Daniel L Glucose meter system and monitor
US20080300572A1 (en) 2007-06-01 2008-12-04 Medtronic Minimed, Inc. Wireless monitor for a personal medical device system
EP2152350A4 (en) 2007-06-08 2013-03-27 Dexcom Inc Integrated medicament delivery device for use with continuous analyte sensor
CN107411754A (en) 2007-06-15 2017-12-01 霍夫曼-拉罗奇有限公司 Visualization of a parameter which is measured on the human body
US9754078B2 (en) 2007-06-21 2017-09-05 Immersion Corporation Haptic health feedback monitoring
EP2562664A3 (en) 2007-06-27 2013-09-18 Roche Diagnostics GmbH System for developing patent specific therapies based on dynamic modeling of patient physiology and method thereof
US20090005729A1 (en) 2007-06-27 2009-01-01 Animas Corporation Medical infusion pumps
WO2009005957A1 (en) 2007-06-29 2009-01-08 Roche Diagnostics Gmbh Apparatus and method for remotely controlling an ambulatory medical device
US8834366B2 (en) 2007-07-31 2014-09-16 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor calibration
US7768386B2 (en) 2007-07-31 2010-08-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US20090036760A1 (en) 2007-07-31 2009-02-05 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in a medical communication system
EP2182838B1 (en) 2007-07-31 2016-05-04 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US7731658B2 (en) 2007-08-16 2010-06-08 Cardiac Pacemakers, Inc. Glycemic control monitoring using implantable medical device
US20090054753A1 (en) 2007-08-21 2009-02-26 Mark Ries Robinson Variable Sampling Interval for Blood Analyte Determinations
US20090062767A1 (en) 2007-08-29 2009-03-05 Medtronic Minimed, Inc. Combined sensor and infusion set using separated sites
US20090063402A1 (en) 2007-08-31 2009-03-05 Abbott Diabetes Care, Inc. Method and System for Providing Medication Level Determination
US20090076360A1 (en) 2007-09-13 2009-03-19 Dexcom, Inc. Transcutaneous analyte sensor
DE102007047351A1 (en) 2007-10-02 2009-04-09 B. Braun Melsungen Ag System and method for monitoring and controlling blood glucose levels
US7972296B2 (en) 2007-10-10 2011-07-05 Optiscan Biomedical Corporation Fluid component analysis system and method for glucose monitoring and control
US8374668B1 (en) 2007-10-23 2013-02-12 Abbott Diabetes Care Inc. Analyte sensor with lag compensation
US8377031B2 (en) 2007-10-23 2013-02-19 Abbott Diabetes Care Inc. Closed loop control system with safety parameters and methods
US8409093B2 (en) 2007-10-23 2013-04-02 Abbott Diabetes Care Inc. Assessing measures of glycemic variability
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
US9839395B2 (en) 2007-12-17 2017-12-12 Dexcom, Inc. Systems and methods for processing sensor data
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US20090164239A1 (en) 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Dynamic Display Of Glucose Information
US20090164251A1 (en) 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Method and apparatus for providing treatment profile management
US20090163855A1 (en) 2007-12-24 2009-06-25 Medtronic Minimed, Inc. Infusion system with adaptive user interface
US20090299155A1 (en) 2008-01-30 2009-12-03 Dexcom, Inc. Continuous cardiac marker sensor system
US8473022B2 (en) 2008-01-31 2013-06-25 Abbott Diabetes Care Inc. Analyte sensor with time lag compensation
WO2009105337A3 (en) 2008-02-20 2010-12-16 Dexcom, Inc. Continuous medicament sensor system for in vivo use
JP5091881B2 (en) 2008-02-20 2012-12-05 カルソニックカンセイ株式会社 Collision detection device
CA2715628A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
US20090242399A1 (en) 2008-03-25 2009-10-01 Dexcom, Inc. Analyte sensor
US8396528B2 (en) 2008-03-25 2013-03-12 Dexcom, Inc. Analyte sensor
WO2009121026A1 (en) 2008-03-28 2009-10-01 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US20110031986A1 (en) 2008-04-11 2011-02-10 Navakanta Bhat Sub-Threshold Capfet Sensor for Sensing Analyte, A Method and System Thereof
US7783342B2 (en) 2008-04-21 2010-08-24 International Business Machines Corporation System and method for inferring disease similarity by shape matching of ECG time series
US7938797B2 (en) 2008-05-05 2011-05-10 Asante Solutions, Inc. Infusion pump system
US8394637B2 (en) 2008-06-02 2013-03-12 Roche Diagnostics Operations, Inc. Handheld analyzer for testing a sample
WO2010009172A1 (en) 2008-07-14 2010-01-21 Abbott Diabetes Care Inc. Closed loop control system interface and methods
US20100057040A1 (en) 2008-08-31 2010-03-04 Abbott Diabetes Care, Inc. Robust Closed Loop Control And Methods
US20100057041A1 (en) 2008-08-31 2010-03-04 Abbott Diabetes Care, Inc. Closed Loop Control With Reference Measurement And Methods Thereof
US8734422B2 (en) 2008-08-31 2014-05-27 Abbott Diabetes Care Inc. Closed loop control with improved alarm functions
US9392969B2 (en) 2008-08-31 2016-07-19 Abbott Diabetes Care Inc. Closed loop control and signal attenuation detection
CA2954728A1 (en) 2008-09-15 2010-03-18 Deka Products Limited Partnership Systems and methods for fluid delivery
US20100095229A1 (en) 2008-09-18 2010-04-15 Abbott Diabetes Care, Inc. Graphical user interface for glucose monitoring system
WO2010033724A3 (en) 2008-09-19 2010-05-20 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US8986208B2 (en) 2008-09-30 2015-03-24 Abbott Diabetes Care Inc. Analyte sensor sensitivity attenuation mitigation
US8287487B2 (en) 2008-10-15 2012-10-16 Asante Solutions, Inc. Infusion pump system and methods
EP3043174B1 (en) 2008-11-04 2017-12-06 Panasonic Healthcare Holdings Co., Ltd. Measurement device
US9320470B2 (en) 2008-12-31 2016-04-26 Medtronic Minimed, Inc. Method and/or system for sensor artifact filtering
US8974439B2 (en) 2009-01-02 2015-03-10 Asante Solutions, Inc. Infusion pump system and methods
US20100198142A1 (en) 2009-02-04 2010-08-05 Abbott Diabetes Care Inc. Multi-Function Analyte Test Device and Methods Therefor
US8394246B2 (en) 2009-02-23 2013-03-12 Roche Diagnostics Operations, Inc. System and method for the electrochemical measurement of an analyte employing a remote sensor
EP2425210A4 (en) 2009-04-28 2013-01-09 Abbott Diabetes Care Inc Dynamic analyte sensor calibration based on sensor stability profile
WO2010127169A3 (en) 2009-04-30 2011-02-03 Dexcom, Inc. Performance reports associated with continuous sensor data from multiple analysis time periods
WO2010141922A1 (en) 2009-06-04 2010-12-09 Abbott Diabetes Care Inc. Method and system for updating a medical device
EP2448485A4 (en) 2009-07-02 2014-07-16 Dexcom Inc Analyte sensor
US20120165626A1 (en) 2009-07-13 2012-06-28 Irina Finkelshtein V Devices, methods, and kits for determining analyte concentrations
US8868151B2 (en) * 2009-08-14 2014-10-21 Bayer Healthcare Llc Electrochemical impedance spectroscopy enabled continuous glucose monitoring sensor system
CN102481110B (en) 2009-08-17 2015-05-20 加利福尼亚大学董事会 Distributed external and internal wireless sensor systems for characterization of surface and subsurface biomedical structure and condition
US9357951B2 (en) 2009-09-30 2016-06-07 Dexcom, Inc. Transcutaneous analyte sensor
US20110148905A1 (en) 2009-12-17 2011-06-23 Bayer Healthcare Llc Apparatus, systems and methods for determining and displaying pre-event and post-event analyte concentration levels
US20110208027A1 (en) 2010-02-23 2011-08-25 Roche Diagnostics Operations, Inc. Methods And Systems For Providing Therapeutic Guidelines To A Person Having Diabetes
WO2011133768A1 (en) 2010-04-22 2011-10-27 Abbott Diabetes Care Inc. Devices, systems, and methods related to analyte monitoring and management
US8726266B2 (en) 2010-05-24 2014-05-13 Abbott Diabetes Care Inc. Method and system for updating a medical device
US9336353B2 (en) 2010-06-25 2016-05-10 Dexcom, Inc. Systems and methods for communicating sensor data between communication devices of a glucose monitoring system
WO2012050926A3 (en) 2010-09-29 2012-06-21 Dexcom, Inc. Advanced continuous analyte monitoring system
US9241631B2 (en) 2010-10-27 2016-01-26 Dexcom, Inc. Continuous analyte monitor data recording device operable in a blinded mode
US20120165640A1 (en) 2010-12-23 2012-06-28 Roche Diagnostics Operations, Inc. Structured blood glucose testing performed on handheld diabetes management devices
CN107019515A (en) 2011-02-28 2017-08-08 雅培糖尿病护理公司 Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
US20130035575A1 (en) 2011-08-05 2013-02-07 Dexcom, Inc. Systems and methods for detecting glucose level data patterns
US8710993B2 (en) 2011-11-23 2014-04-29 Abbott Diabetes Care Inc. Mitigating single point failure of devices in an analyte monitoring system and methods thereof
US20130235166A1 (en) 2012-03-07 2013-09-12 Cambridge Silicon Radio Limited Synchronisation method
US20150241407A1 (en) 2012-08-30 2015-08-27 Abbott Diabetes Care Inc. Dropout Detection in Continuous Analyte Monitoring Data During Data Excursions

Patent Citations (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7011630B2 (en) * 2001-06-22 2006-03-14 Animas Technologies, Llc Methods for computing rolling analyte measurement values, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods
US20050049473A1 (en) * 2001-06-22 2005-03-03 Cygnus, Inc. Methods for estimating analyte-related signals, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods
US7699775B2 (en) * 2001-06-22 2010-04-20 Animas Technologies, Llc Methods for estimating analyte-related signals, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods
US20030050546A1 (en) * 2001-06-22 2003-03-13 Desai Shashi P. Methods for improving the performance of an analyte monitoring system
US20040024553A1 (en) * 2002-03-08 2004-02-05 Monfre Stephen L. Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers
US6998247B2 (en) * 2002-03-08 2006-02-14 Sensys Medical, Inc. Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers
US7183102B2 (en) * 2002-03-08 2007-02-27 Sensys Medical, Inc. Apparatus using reference measurement for calibration
US20050196821A1 (en) * 2002-03-08 2005-09-08 Monfre Stephen L. Method and apparatus for using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers
US7519478B2 (en) * 2002-03-22 2009-04-14 Animas Technologies, Llc Microprocessors, devices and methods for use in analyte monitoring systems
US20030235817A1 (en) * 2002-03-22 2003-12-25 Miroslaw Bartkowiak Microprocessors, devices, and methods for use in analyte monitoring systems
US7523004B2 (en) * 2002-03-22 2009-04-21 Animas Technologies, Llc Micropressors, devices and methods for use in analyte monitoring systems
US7711493B2 (en) * 2002-03-22 2010-05-04 Animas Corporation Micropressors, devices and methods for use in analyte monitoring systems
US20050187720A1 (en) * 2003-08-01 2005-08-25 Dexcom, Inc. System and method for processing analyte sensor data
US7276029B2 (en) * 2003-08-01 2007-10-02 Dexcom, Inc. System and methods for processing analyte sensor data
US7826981B2 (en) * 2003-08-01 2010-11-02 Dexcom, Inc. System and methods for processing analyte sensor data
US20050027181A1 (en) * 2003-08-01 2005-02-03 Goode Paul V. System and methods for processing analyte sensor data
US20050027463A1 (en) * 2003-08-01 2005-02-03 Goode Paul V. System and methods for processing analyte sensor data
US8060173B2 (en) * 2003-08-01 2011-11-15 Dexcom, Inc. System and methods for processing analyte sensor data
US7778680B2 (en) * 2003-08-01 2010-08-17 Dexcom, Inc. System and methods for processing analyte sensor data
US20050027180A1 (en) * 2003-08-01 2005-02-03 Goode Paul V. System and methods for processing analyte sensor data
US20050027462A1 (en) * 2003-08-01 2005-02-03 Goode Paul V. System and methods for processing analyte sensor data
US7885697B2 (en) * 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US7905833B2 (en) * 2004-07-13 2011-03-15 Dexcom, Inc. Transcutaneous analyte sensor
US7946984B2 (en) * 2004-07-13 2011-05-24 Dexcom, Inc. Transcutaneous analyte sensor
US8170803B2 (en) * 2004-07-13 2012-05-01 Dexcom, Inc. Transcutaneous analyte sensor
US7857760B2 (en) * 2004-07-13 2010-12-28 Dexcom, Inc. Analyte sensor
US7713574B2 (en) * 2004-07-13 2010-05-11 Dexcom, Inc. Transcutaneous analyte sensor
US8376945B2 (en) * 2006-08-09 2013-02-19 Abbott Diabetes Care Inc. Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US20100064764A1 (en) * 2006-08-09 2010-03-18 Abbott Diabetes Care Inc. Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System
US20080039702A1 (en) * 2006-08-09 2008-02-14 Abbott Diabetes Care, Inc. Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System
US7653425B2 (en) * 2006-08-09 2010-01-26 Abbott Diabetes Care Inc. Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US9408566B2 (en) * 2006-08-09 2016-08-09 Abbott Diabetes Care Inc. Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US20130231541A1 (en) * 2006-08-09 2013-09-05 Abbott Diabetes Care Inc. Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System
US7751864B2 (en) * 2007-03-01 2010-07-06 Roche Diagnostics Operations, Inc. System and method for operating an electrochemical analyte sensor
US8260558B2 (en) * 2007-05-14 2012-09-04 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8239166B2 (en) * 2007-05-14 2012-08-07 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US7996158B2 (en) * 2007-05-14 2011-08-09 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8560038B2 (en) * 2007-05-14 2013-10-15 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8600681B2 (en) * 2007-05-14 2013-12-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8444560B2 (en) * 2007-05-14 2013-05-21 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8543354B2 (en) * 2010-06-23 2013-09-24 Medtronic Minimed, Inc. Glucose sensor signal stability analysis
US8657746B2 (en) * 2010-10-28 2014-02-25 Medtronic Minimed, Inc. Glucose sensor signal purity analysis

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