US20160235562A1 - Flexible stent with torque-absorbing connectors - Google Patents

Flexible stent with torque-absorbing connectors Download PDF

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Publication number
US20160235562A1
US20160235562A1 US15/137,465 US201615137465A US2016235562A1 US 20160235562 A1 US20160235562 A1 US 20160235562A1 US 201615137465 A US201615137465 A US 201615137465A US 2016235562 A1 US2016235562 A1 US 2016235562A1
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Prior art keywords
endoprosthesis
web
plurality
junction
segment
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Abandoned
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US15/137,465
Inventor
Brendan J. Casey
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Abbott Laboratories Vascular Enterprises Ltd
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Abbott Laboratories Vascular Enterprises Ltd
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Publication date
Priority to US11/805,584 priority Critical patent/US8016874B2/en
Priority to US11/973,707 priority patent/US8128679B2/en
Priority to US13/411,135 priority patent/US9320627B2/en
Application filed by Abbott Laboratories Vascular Enterprises Ltd filed Critical Abbott Laboratories Vascular Enterprises Ltd
Priority to US15/137,465 priority patent/US20160235562A1/en
Assigned to ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITED reassignment ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CASEY, BRENDAN J.
Publication of US20160235562A1 publication Critical patent/US20160235562A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/89Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541Adjacent bands are arranged out of phase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91558Adjacent bands being connected to each other connected peak to peak
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0069Three-dimensional shapes cylindrical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A61F2250/0031Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts

Abstract

The present invention concerns an endoprosthesis with a highly flexible structure that is configured to provide an elevated degree of vessel scaffolding and to absorb torque applied on the endoprosthesis. In one embodiment, a method of deploying the endoprosthesis in a body lumen includes locating an endoprosthesis in a contracted delivery configuration in the body lumen, disposing the endoprosthesis in a location of the body lumen to receive the endoprosthesis in an expanded deployed configuration, and deploying the endoprosthesis to transition the endoprosthesis from the contracted delivery configuration to the expanded deployed configuration. The endoprosthesis includes a plurality of longitudinally adjacent web rings including a plurality of adjoined web elements and a plurality of junction bends adjoining pairs of the plurality of adjoined web elements, and S-shaped connectors for connecting the web rings.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • The present application is a divisional application of U.S. patent application Ser. No. 13/411,135 filed Mar. 2, 2012, which is a continuation application of U.S. patent application Ser. No. 11/973,707, filed on Oct. 9, 2007, now U.S. Pat. No. 8,128,679, which is a Continuation-in-Part application of U.S. patent application Ser. No. 11/805,584 filed on May 23, 2007, now U.S. Pat. No. 8,016,874, the entireties of which are incorporated herein by reference.
  • BACKGROUND OF THE INVENTION
  • 1. The Field of the Invention
  • The present invention relates to a medical device. More particularly, the present invention relates to a flexible stent that provides elevated torque-absorbing properties.
  • 2. The Relevant Technology
  • Atherosclerosis, sometimes called the hardening or clogging of the arteries, is an accumulation of cholesterol and fatty deposits, called plaque, on the inner walls of the arteries. Atherosclerosis causes a partial or total blockage of the arteries and, consequently, a reduced blood flow to the heart, legs, kidneys, or brain.
  • Traditionally, clogged arteries have been treated with surgical procedures that involve the removal of the diseased arterial tract. Angioplasty procedures, during which a stent is inserted in the diseased portion of the artery, have gained increased acceptance during the last two decades because of the reduced complexity of this procedure in comparison with other surgical procedures and because of the consequent reduction in risk and discomfort to the patient.
  • Referring first to FIG. 1, a stent 20 is a small tubular element that typically has a cylindrical structure 22 and that, once placed within a blocked vessel, acts as a scaffold that keeps the vessel open. Stent 20 may be implanted in a bodily vessel by disposing the stent over a balloon tipped catheter, by driving the stent to a target location in a vessel, and by subsequently inflating the balloon at the target location.
  • Alternatively, stent 20 may be caused to self-expand without the use of a balloon by manufacturing stent 20 from a shape memory material and by disposing stent 20 over a catheter in a contracted delivery configuration. Stent 20 is successively driven to a target location in a vessel, where a sheath covering stent 20 is withdrawn and stent 20 is allowed to self-expand. One type of self-expanding stent is produced from a superelastic material and is compressed inside the sheath into a contracted delivery configuration. When the stent is released from the sheath, the flexible material causes the stent to spring back to its original shape and size before compression. Another type of self-expanding stent is produced from a thermo-elastic shape-memory material that is formed into a desired size and shape and is then annealed at a temperature higher than a transition temperature. After cooling the stent to a temperature below the transition temperature, the stent becomes soft and can be reduced to a smaller size by crimping, so that it can be delivered to the target location, where the stent is warmed to a temperature above the transition temperature and returns to the preprogrammed size and shape. The present invention relates to both to balloon expandable stents and to self-expanding stents, as explained in greater detail in the following sections.
  • The stents in the prior art are formed as a metal mesh or, in general, as a web structure that provides some degree of flexibility. Certain types of anatomies require that stents with elevated degrees of flexibility be employed, for example, stents to be implanted in the carotid artery, because the bifurcated anatomy of the carotid artery and frequent movements of that part of the body require a stent that can adapt to such anatomy. The stent designs in the prior art typically increase flexibility by increasing cells size in the mesh or in the web structure. Therefore, whenever stent flexibility is increased in the stents in the prior art, scaffolding support is affected negatively due to the related reduction in web density.
  • A prior art stent is disclosed in U.S. Pat. No. 5,104,404, which teaches an articulated stent in which stent segments, formed by diamond-shaped cells disposed in ring form, are connected one to the other at some but not all of the tips of the diamond-shaped cells. This arrangement provides for a stent with a high degree of longitudinal flexibility, but also for limited support to the arterial walls at the junctions areas between the different stent segments.
  • With reference now to FIG. 2, other designs in the prior art have attempted to increase stent flexibility by forming the stent as a plurality of web rings 24 that are disposed longitudinally along tubular body 22 and that are coupled one to the other by flexible connectors 26. Designs of this type are disclosed in U.S. patent application Ser. No. 10/743,857, U.S. Pat. Nos. 6,682,554 and 6,602,285, International Application PCT/EP99/06456, and German Patent Application Serial No. 19840645.2, the entireties of which are incorporated herein by reference. The function of flexible connectors 26 is to facilitate the bending of stent 20 by creating longitudinal segments softer than web rings 24. At the same time, flexible connectors 26 transmit torque from one web ring 24 to adjacent web rings 24 when a bending force is applied to tubular body 22 or when a radial force is applied to tubular body 22, for example, during deployment of stent 22 from the contracted delivery configuration to the expanded delivery configuration. Such a transmission of torque may cause different web rings 24 to rotate differentially upon application of a bending force or upon deployment of stent 20.
  • One example of stent construction based on longitudinally alternating of web rings coupled by flexible connectors can be found in U.S. Pat. No. 6,190,403, which discloses a stent having a plurality of web rings disposed in longitudinal order. Each of the web rings is formed by longitudinally-oriented cells disposed circumferentially and is joined to a neighboring web ring by sinusoidal connectors that couple cell tips that are longitudinally aligned one with the other. The stent of the '403 patent provides an elevated degree of scaffolding to the arterial walls, though its structure provides only for a limited degree of longitudinal flexibility due to the limited extent of longitudinal translation that is possible between web rings when a compressive force is applied.
  • Another example of stent construction based on longitudinally alternating web rings coupled by flexible connectors can be found in U.S. Pat. No. 6,451,049, which discloses a stent having a plurality of waveform rings coupled by longitudinal connectors that include a “U” bend. This construction also provides for an elevated degree of scaffolding of the vessel walls, but its flexibility is constrained by the limited ability to compress of the flexible segments.
  • In order to increase stent flexibility, stent designs have been introduced in which the flexible connectors between web rings do not have a longitudinal orientation but instead have a transverse orientation. Examples of such stent designs can be found in U.S. Pat. Nos. 5,980,552; 6,059,811; 6,508,834; and 6,589,276. The transverse orientation of the flexible connectors induce the web rings to rotate one in relation to the other upon the application of a bending or radial force to the stent, and in order to reduce torsional stress in the stent during bending and during expansion, the flexible connectors may have alternating directions. For example, the flexible connectors connecting two neighboring rings may be oriented in a direction opposite to the direction of the next set of flexible connectors. If the web rings are prevented from rotating, the torsional stress in the stent becomes absorbed by the flexible connectors and by the web rings, possibly causing the connectors to warp along their entire length. Additionally, this type of construction causes a foreshortening of the stent during expansion.
  • This problem is illustrated in greater detail in FIGS. 3A-3B. A typical connector 28 couples first web ring 30 to second web ring 32 by connecting junction bend 34 on first ring 30 to junction bend 36 on second ring 32. In order for stent 38 to provide an elevated degree of scaffolding to the vessel within which stent 38 is implanted, each junction bend 34 on web ring 30 is coupled to a junction bend 36 in web ring 32, increasing stent density. The higher the density of stent 38, however, the lower the flexibility, which may be increased by increasing the length of connector 28.
  • When the length of connector 28 is increased, the bending capability and the flexibility of stent 38 is increased correspondingly because the moment applied by connector 28 to web rings 30 and 32 upon the application of a bending force on stent 34 is increased correspondingly. Unfortunately, long connectors disposed transversally on stent 38 can extend along a significant amount of the outer circumference of stent 38. For example, if stent 38 has a diameter of 1.6 mm and if connector 28 is one mm long, connector 28 extends for approximately 72 degrees along the circumference of stent 38. In turn, long connectors 28 will exert a significant amount of torque on junction bends 34 and 36, and, consequently, on web rings 30 and 32, and may warp along their entire length. In addition, long connectors 28 cause the size of stent cells to increase during expansion, therefore, long connectors cause a reduction in the scaffolding properties of stent 20, or a reduction in the ability of stent 20 to effectively support the vessel, into which stent 20 is implanted.
  • By having long connectors 28 disposed in a direction essentially perpendicular to the longitudinal axis of stent 20, connector 28 also tend to retain the bend radius of stent 20 during expansion and to cause a distortion of stent 20 in the expanded configuration.
  • Attempts have been made in the prior art to provide long connectors that extend along relatively limited portions of the circumference of stent 38 and that increase vessel support. For example, U.S. Pat. Nos. 5,449,373; 6,203,569; 6,740,114; 6,790,227; 6,942,689; 6,955,686; 6,998,060; 6,679,911; and 6,875,228 disclose stent constructions, in which the connectors have a variety of shapes in the form of the letters “M”, “N”, “W” or similar shapes, but which all include a plurality of segments oriented at certain angles with respect to the longitudinal axis of the stent. In particular, each of the prior art designs contains one or more central segments that are oriented at an angle with respect to the longitudinal axis of the stent, causing rotations in different degrees upon the application of a torsional force on the connector, for example due to a bending of the stent or during expansion.
  • Therefore, it would be desirable to provide a stent that generates an elevated degree of scaffolding to a bodily vessel while remaining highly flexible.
  • It would also be desirable to provide a stent, in which long connectors can be employed to increase stent flexibility and that can absorb torsional forces applied to the stent without warping along their entire lengths.
  • BRIEF SUMMARY OF THE INVENTION
  • A stent according to the present invention exhibits a highly flexible structure and elevated scaffolding properties, and at the same time is configured to absorb torque applied on the stent by bending or radial forces.
  • The stent according to the present invention is expandable from a contracted delivery configuration to an expanded deployed configuration and includes an essentially tubular body formed by a plurality of web rings disposed longitudinally. Each of the web rings is defined by a plurality of web elements that are disposed circumferentially and that, in the contracted delivery configuration, are substantially parallel to the longitudinal axis of the tubular body. Pairs of the web elements are sequentially adjoined at junction bends, and a junction bend in a first web ring is coupled to a junction bend in a neighboring web ring by one of the connectors.
  • Each of the connectors is formed by a plurality of segments disposed in a step-wise configuration. At least one of the connector segments is situated in a central position within the connector and is disposed with an orientation essentially parallel to the longitudinal axis of the stent. These connectors couple junction bends that are laterally offset one in relation to the other, making the connectors span diagonally along the profile of the tubular body.
  • The second segment may be rectilinear in shape and become twisted to acquire a helical curvature when a bending or expansion stress is applied to the stent. In one embodiment, the central element may be pre-deformed with a helical curvature in the contracted delivery configuration that becomes more accentuated during a bending or expansion of the stent. The central element may also be manufactured to have a cross-sectional area that is different from the cross-sectional areas of the end segments.
  • In one embodiment, each of the junction bends in the first web ring is connected to one junction bend in one neighboring web ring by one connector, so that each junction bend in one web ring is coupled to another junction bend in an adjacent web ring.
  • The stent of the present invention may be manufactured from a variety of materials, including metallic materials and plastic materials. When the stent is to be self-expanding, Nitinol or another shape memory material may be employed, while a balloon-expandable stent may be manufactured from stainless steel or other biocompatible metallic or plastic material. All or part of the stent (for example, the connector) may also be manufactured from a biodegradable material, for example, from a plastic absorbing material. In addition, the stent of the present invention may include a number of ancillary features known in the art, for example, may be coated with a bioactive agent or contain radio-opaque markers.
  • Methods of use of the stent according to the present invention are also provided.
  • BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS
  • The drawings constitute a part of this specification and include exemplary embodiments of the invention, which may be embodied in various forms. It is to be understood that in some instances various aspects of the invention may be shown exaggerated or enlarged to facilitate an understanding of the invention.
  • FIG. 1 is a perspective view of an essentially tubular body of a stent.
  • FIG. 2 is a front view of a stent connector according to the prior art.
  • FIG. 3A illustrates a configuration of stent connector according to the prior art, and
  • FIG. 3B is a schematic top view of the essentially tubular body of a stent highlighting the span of the connector of FIG. 3B when disposed within the tubular body.
  • FIG. 4 is a perspective view of one embodiment of the present invention, showing the stent pattern in a detail view.
  • FIG. 5 is a detail view, illustrated as a flattened surface, of the web structure of a stent according to one embodiment of the present invention.
  • FIG. 5A is a detail view, illustrated as a flattened surface, of the web structure of a stent according to an embodiment of the present invention.
  • FIG. 6 is a detail view of the web structure of FIG. 5.
  • FIG. 7 is a schematic plan view of a connector connecting two neighboring junction bends according to one embodiment of the present invention.
  • FIG. 8 is a perspective view of the connector of FIG. 7.
  • DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION
  • The present invention relates to stent designs that can absorb an elevated degree of torque during expansion and after implantation in a patient while at the same time providing a highly flexible stent structure. One application of the present invention relates to closed cell stents, in particular, carotid stents, for which an elevated degree of lesion scaffolding and the capability of conforming to tortuous anatomies are key design features.
  • Detailed descriptions of embodiments of the invention are provided herein. It is to be understood, however, that the present invention may be embodied in various forms. Therefore, the specific details disclosed herein are not to be interpreted as limiting, but rather as a representative basis for teaching one skilled in the art how to employ the present invention in virtually any detailed system, structure, or manner.
  • Referring to FIG. 4, a stent 40 constructed according to the principles of the present invention includes an essentially tubular body 42 expandable from a contracted delivery configuration to an expanded deployed configuration. While body 42 is depicted in FIG. 4 as essentially cylindrical in shape, body 42 may be provided with other shapes, for example, with a frustoconical shape or with the shape of a hyperboloid.
  • Body 42 is defined by a web structure 44, shown in FIG. 4 only in a detail view that relates to the contracted delivery configuration. Web structure 44 includes a plurality of web elements 46, each formed by a plurality of crowns 48.
  • Referring now to FIG. 5, each crown 48 includes a central member 50 having a first end member 52 and a second end member 54 extending respectively from the opposite ends of central member 50. Central member 50, first end member 52 and second end member 54 are each essentially linear in shape, and, in the contracted delivery configuration of stent 40, central member 50 is disposed essentially parallel to the longitudinal axis of body 42 (see also FIG. 4), while first and second members 52 and 54 extend from central member 50 at obtuse angles. Preferably, first and second members 52 and 54 extend from central member 50 at the same angle, but in other embodiments, first and second members 52 and 54 may extend from central member 50 at different angles. In still other embodiments, one or more of central member 50 and first and second members 52 and 54 may be non-rectilinear and have a curved shape.
  • Crowns 48 are nested one into the other in the contracted delivery configuration and are sequentially adjoined at one end by a junction bend 56 that exhibits an essentially arcuate shape. A series of crowns 48 is disposed circumferentially about the longitudinal axis of body 42 to form web rings 46, which are joined one to the other by connectors 58. As shown in FIG. 5, the crowns in one web ring may be disposed with an orientation that is opposite to the orientation of the crowns in a neighboring web ring. In the illustrated embodiment, two adjacent web rings are disposed with an orientation of crowns 48 that is 180 degrees different one from the other.
  • Stent 40 may be manufactured from a variety of biocompatible materials, including metal and plastic materials. For example but not by way of limitation, stent 40 may be manufactured from Nitinol or other shape memory material if a self-expanding configuration of stent 40 is desired, or from stainless steel if balloon expansion is foreseen. Alternatively, stent 40 may be manufactured from a plastic material that enables either a permanent stent placement or a temporary stent placement, for example, from a plastic absorbing material.
  • In some embodiments, crowns 48 and connectors 58 may be manufactured from a biodegradable material when it is expected that only temporary vessel support is required. In another embodiment, only connectors 58 may be manufactured from a biodegradable material, so that the scaffolding provided by stent 40 may change over time and connectors 58 will gradually dissolve in the fluid carried by the vessel (for example, blood), leaving web rings 46 intact and allowing web rings 46 to be disposed at specific angles in relation to each other, as required by the patient's anatomy or by the movements of the patient's body.
  • While FIG. 5 illustrates that each junction bend 56 in one web ring is adjoined by connector 58 to a junction bend 60 in the adjacent web ring, only one out of a plurality of junction bends in one web ring (for example, one every three) may be adjoined to a junction bend in an adjacent web ring, providing stent 40 with larger open spaces between adjacent web rings 46. An example of which is shown in FIG. 5A. For example, the web ring 45 a shown on the left is only connected to the web ring 45 b in the middle by a single connector 58 (e.g. shown in black), such that the connector 58 is separated by at least seven junction bends 60. In another example, the web ring 45 c on the right is connected to the web ring 45 b in the middle by two connectors 58, such that the two connectors 58 are separated by three unadjoined junction bends 60. Thus, FIG. 5A illustrates an embodiment of an endoprosthesis configured to transition from a contracted delivery configuration to an expanded deployed configuration. The endoprosthesis includes a plurality of longitudinally adjacent web rings 45 a-c defining an essentially tubular web structure, each web ring 45 a-c including a plurality of adjoined web elements 46, 48. The endoprosthesis includes a plurality of junction bends 56, 60 adjoining pairs of the plurality of adjoined web elements 46, 48, a first junction bend 56 in a first web ring 45 b of the plurality of longitudinally adjacent web rings 45 a-c is connected to a second junction bend 60 in an adjacent neighboring web ring 46 c of the plurality of longitudinally adjacent web rings 45 a-c by a first S-shaped connector 58 a, the second junction bend 60 being longitudinally offset from the first junction bend 56 and being circumferentially separated from the first junction bend 56, a third junction bend 57 in the first web ring 45 b of the plurality of longitudinally adjacent web rings 45 a-c is connected to a fourth junction bend 61 in the adjacent neighboring web ring 45 c of the plurality of longitudinally adjacent web rings 45 a-c by a second S-shaped connector 58 b, the fourth junction bend 61 being longitudinally offset from the third junction bend 57 and being circumferentially separated from the third junction bend 57, the first junction bend 56 being circumferentially separated from the third junction bend 57 by at least three unadjoined junction bends 59, the first and second S-shaped connectors 58 a, 58 b having a plurality of segments disposed one in relation to the other in step-wise configuration, the plurality of segments being interconnected by connectors. While this more open design increases stent flexibility, the scaffolding properties of the stent are correspondingly decreased because of decreased stent density.
  • One aspect of the present invention is to provide an elevated degree of flexibility while retaining a closed cell structure, in which each junction bend 56 in one web ring 46 is coupled to a junction bend 60 in a neighboring web ring 46. Therefore, stent 40 is well suited for delivery and implantation at sites that require elevated flexibility and elevated scaffolding, for example, in carotid arteries. At the same time, the step-wise configuration of connectors 58 enables the use of connectors 58 which are relatively long, increasing flexibility to suit tortuous anatomies and various body movements, but through which the torsion of one web ring 46 in relation to the other is decreased or eliminated, as explained in greater detail below.
  • It should be observed that each of connectors 58 does not adjoin two junction bends that are longitudinally aligned, but instead adjoin two junction bends 56 and 60 that are laterally offset one in relation to the other. This offset configuration is more advantageous than a configuration linking adjacent junction bends. More specifically, a configuration with connectors 58 linking junction bends 56 and 60 that are offset one from the other provides an elevated degree of flexibility to stent 40, because in this configuration neighboring web rings have a greater ability to rotate one in relation to the other when stent 40 is deployed or becomes subjected to a bending stress.
  • Connectors 58 may join adjacent junction bends 56 and 60 at different points within the junction bends. For example, in the embodiment shown in FIG. 5 and, in greater detail, in FIG. 6, connector 58 adjoins essentially the middle points of junction bends 56 and 60 by extending from essentially the middle point of junction bend 56 to essentially the middle point of junction bend 60. In other embodiments, connector 58 may adjoin the lowest point in junction bend 56 with the highest point of junction bend 60, or the highest point of junction bend 56 with the lowest point of junction bend 60. It should be understood that in still other embodiments, connectors 58 may join junction bends 56 and 60 at a plurality of different points of the junction bends, and that some of the crowns 46 and connectors 58 are shown in FIGS. 5 and 6 in darkened color only for illustrative purposes and not for indicating any particular structural or design differences from the neighboring crowns and connectors.
  • The structure and mode of operation of connector 58 is illustrated in greater detail in FIGS. 6 and 7. More particularly, connector 58 includes a first segment 62, a second (middle) segment 64 and a third segment 66, disposed one in relation to the other in a step-wise configuration. Within the structure of connector 58, first segment 62 couples connector 58 with junction bend 56, third connector 66 couples connector 58 with junction bend 60, while second segment 64 couples first segment 62 with third segment 66. Second segment 64 is arranged in a direction essentially parallel to the longitudinal axis of body 42, while first segment 62 and third segment 66 are arranged at an angle A with respect to second segment 64, for example, 110 degrees as shown in FIG. 7. In different embodiments, connector 58 may be composed of different numbers of segments, which may further be arranged at angles of varying amplitudes, for example, between 100 and 170 degrees.
  • Referring now to FIGS. 7 and 8, the configuration of connector 58 is such to absorb a torsional stress applied to body 42, particularly during expansion of the stent from the contracted delivery configuration to the expanded deployed configuration. Such an ability to absorb torque is provided not only by the relative movements of first segment 62 and third segment 66, by which the widths of angle A between second segment 64 and first segment 62, and of angle B between second segment 64 and third segment 66, may change as a consequence of torsional stress, but also by the twisting motion of second segment 64 to assume an essentially helical shape. By the twisting motion of second segment 64, the torsional stress from, for example, first segment 62 is not entirely transmitted to third segment 66, but is absorbed (entirely or partially) by the twisting motion of second segment 64.
  • By disposing second segment 64 in a direction essentially parallel to the longitudinal axis of tubular body 42, torque developing, for example, during deployment of the stent is absorbed at a much greater rate than in stent configurations having second segment 64 disposed at an angle in relation to the longitudinal axis of tubular body 42. Therefore, the connector design of the present invention absorbs torque at a greater rate than, for example, designs where the connectors between the web rings have shapes reminiscent of the letters “N” or “W”, because the structure of connector 58 according to the present invention minimizes or eliminates the relative rotations of one web ring 46 in relation of a neighboring web ring 46. At the same time, second segment 64 provides for a greater scaffolding of the vessel walls than connector designs in which no step-like pattern is present, in particular, than designs having no longitudinally disposed segments. By having second segment 64 disposed essentially parallel to the longitudinal axis of tubular body 42, second segment 64 can become twisted, minimizing or eliminating the distortion problems in stents of the prior art that have long connectors, and improving surface contact of stent 40 with the vessel, within which stent 40 is disposed.
  • FIG. 8 illustrates in greater detail that second segment 64 has become deflected after the application of torsional stress on web structure 44, for example, when web structure 44 is expanded during the deployment of stent 40 and the web rings on which junction bends 56 and 60 are situated tend to rotate one with respect to the other. During such absorption of torque, connecting area 68 between first segment 62 and second segment 64 may become tilted in a direction opposite to that of connecting area 70 between second segment 64 and third segment 66 when second segment 64 assumes a helical disposition. This phenomenon is particularly relevant when stent 40 is manufactured by producing its shape from a tube, for example through a laser cutting process, so that connectors 58 exhibit edges that are substantially square. In one embodiment of the invention, the twisting motion of second segment 64 towards a helical disposition may be facilitated by manufacturing connector 58 with connecting areas 68 and 70 disposed not one parallel to each other, but instead at an angle one with respect to the other.
  • Stent 40 may be disposed into a target vessel location, for example, in a location within a carotid artery, by inserting a guide wire into the artery, and by successively translating a catheter along the guide wire that carries the stent in a contracted condition. When the stent has reached the target location, as may be determined by tracking radio-opaque markers embedded in the stent, a balloon disposed on the catheter and within the stent is inflated, causing the stent to expand from the contracted condition to the deployed condition until contact with the vessel walls is achieved. Alternatively, if the stent is manufactured from a self-expanding material, after the target location has been reached, a sheath covering the stent is withdrawn, enabling the stent to self-expand until contact with the vessel walls is made and a support structure is created.
  • By providing a stent having a structure formed by web elements that are disposed in web rings and that are coupled by connectors in the manner described herein, so to form a closed cell structure, an improved support is provided to the vessel walls in comparison with open cell stents, and a highly flexible structure is achieved that provides an elevated degree of scaffolding support to the vessel walls even when the vessel is bent.
  • Stent 40 may include different features known in the art to provide certain beneficial properties. For example but not by way of limitation, stent 40 may be coated with a therapeutic coating that includes a bioactive agent, or may contain radiopaque markers, or may be coupled to a fabric that prevents the passage of emboli from the vessel wall into the blood stream.
  • It should be noted that, while the invention has been described in connection with the above described embodiments, it is not intended to limit the scope of the invention to the particular forms set forth, but on the contrary, it is intended to cover such alternatives, modifications, and equivalents as may be included within the scope of the invention. Accordingly, the scope of the present invention fully encompasses other embodiments that may become obvious to those skilled in the art and the scope of the present invention is limited only by the appended claims.

Claims (20)

What is claimed is:
1. A method of deploying an endoprosthesis in a body lumen, the method comprising:
positioning an endoprosthesis in a contracted delivery configuration in the body lumen, the endoprosthesis comprising:
a plurality of web rings, each web ring including a plurality of web elements and a plurality of junction bends disposed between adjacent web elements of the plurality of web elements; and
a plurality of S-shaped connectors extending from the plurality of junction bends and between longitudinally spaced apart web rings of the plurality of web rings, at least three junction bends separating the junction bends from which adjacent S-shaped connectors extend; and
deploying the endoprosthesis to transition the endoprosthesis from the contracted delivery configuration to an expanded deployed configuration.
2. The method of claim 1, wherein the S-shaped connector comprises a first segment, a second segment, and a central segment disposed between the first segment and the second segment, a junction between the first segment and the central segment being non-parallel to a junction between the second segment and the central segment.
3. The method of claim 2, wherein the junction between the first segment and the central segment and the junction between the second segment and the central segment are transverse to a longitudinal axis of the web rings.
4. The method of claim 2, wherein the junction between the first segment and the central segment is tilted in a direction opposite the junction between the second segment and the central segment when in the expanded deployed configuration.
5. The method of claim 2, wherein an angle between the first segment and the central segment, and the central segment and the second segment, is between about 45 and 135 degrees or about 100 and 170 degrees.
6. The method of claim 1, wherein deploying the endoprosthesis comprises twisting the S-shaped connector as the endoprosthesis transitions from the contracted delivery configuration to the expanded deployed configuration.
7. A method of deploying an endoprosthesis in a body lumen, the method comprising:
locating an endoprosthesis in a contracted delivery configuration in the body lumen, the endoprosthesis comprises a plurality of longitudinally adjacent web rings defining an essentially tubular web structure, each web ring including a plurality of adjoined web elements and a plurality of junction bends adjoining pairs of the plurality of adjoined web elements, a junction bend in a first web ring of the plurality of longitudinally adjacent web rings is connected to a second junction bend in a neighboring web ring of the plurality of longitudinally adjacent web rings by an S-shaped connector, the second junction bend being longitudinally offset from the first junction bend and being circumferentially offset from the first junction bend by a plurality of other junction bends of a plurality of junction bends of the neighboring web ring, the S-shaped connector having a plurality of segments disposed one in relation to the other in step-wise configuration;
disposing the endoprosthesis in a location of the body lumen to receive the endoprosthesis in an expanded deployed configuration; and
deploying the endoprosthesis to transition the endoprosthesis from the contracted delivery configuration to the expanded deployed configuration.
8. The method of claim 7, wherein the S-shaped connector comprises three segments, two segments of the three segments being essentially parallel, wherein deploying the endoprosthesis comprises translating one of the two essentially parallel segments relative to the other essentially parallel segments by application of a bending force on the essentially tubular web structure.
9. The method of claim 7, wherein deploying the endoprosthesis further comprises applying pressure to an interior surface of the essentially tubular web structure.
10. The method of claim 7, wherein disposing the endoprosthesis comprises advancing the endoprosthesis through the body lumen.
11. A method of deploying an endoprosthesis in a body lumen, the method comprising:
positioning an endoprosthesis in a contracted delivery configuration in the body lumen, the endoprosthesis comprising:
a plurality of longitudinally adjacent web rings, each web ring including a plurality of adjoined web elements and a plurality of junction bends adjoining pairs of the plurality of adjoined web elements,
wherein, a junction bend in a first web ring of the plurality of longitudinally adjacent web rings is connected to a second junction bend in a neighboring web ring of the plurality of longitudinally adjacent web rings by an S-shaped connector, the first junction bend being separated from a third junction bend, from which another S-shaped connector extends, by at least three junction bends without an associated S-shaped connector; and
deploying the endoprosthesis to transition the endoprosthesis from the contracted delivery configuration to an expanded deployed configuration.
12. The method of claim 11, wherein the S-shaped connector comprises three segments, two segments of the three segments being essentially parallel, wherein the web rings are essentially tubular, wherein deploying the endoprosthesis comprises translating one of the two essentially parallel segments relative to the other essentially parallel segments by application of a bending force on the essentially tubular web rings.
13. The method of claim 11, wherein deploying the endoprosthesis further comprises applying pressure to an interior surface of the essentially tubular web rings.
14. The method of claim 11, wherein positioning the endoprosthesis comprises advancing the endoprosthesis through the body lumen.
15. The method of claim 11, wherein the S-shaped connect comprises a plurality of segments disposed one in relation to the other in a step-wise configuration.
16. The method of claim 15, wherein a central segment of the plurality of segments within the connector is disposed in a direction essentially parallel to a longitudinal axis of the endoprosthesis.
17. The method of claim 11, wherein each of the web elements comprises a central member having a first and a second ends, wherein the central member is disposed essentially parallel to a longitudinal axis in the contracted delivery configuration, wherein the central member is connected at the first end to a first end member at a first obtuse angle, and wherein the central member is connected at the second end to a second end member at a second obtuse angle.
18. The method of claim 17, wherein the first and the second obtuse angles are essentially equal.
19. The method of claim 17, wherein the web elements of each web ring are nested one into the other in the contracted delivery configuration, and wherein the junction bends have an arcuate shape.
20. The method of claim 11, wherein the web elements in the first web ring are oriented at approximately 180 degrees in relation to the web elements in the neighboring web ring.
US15/137,465 2007-05-23 2016-04-25 Flexible stent with torque-absorbing connectors Abandoned US20160235562A1 (en)

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US11/805,584 US8016874B2 (en) 2007-05-23 2007-05-23 Flexible stent with elevated scaffolding properties
US11/973,707 US8128679B2 (en) 2007-05-23 2007-10-09 Flexible stent with torque-absorbing connectors
US13/411,135 US9320627B2 (en) 2007-05-23 2012-03-02 Flexible stent with torque-absorbing connectors
US15/137,465 US20160235562A1 (en) 2007-05-23 2016-04-25 Flexible stent with torque-absorbing connectors

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EP2192878A1 (en) 2010-06-09
US8128679B2 (en) 2012-03-06
US20120165921A1 (en) 2012-06-28
US20080294240A1 (en) 2008-11-27
US9320627B2 (en) 2016-04-26
EP2192878B1 (en) 2014-04-16

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