US20150141636A1 - Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity - Google Patents

Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity Download PDF

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Publication number
US20150141636A1
US20150141636A1 US14/341,402 US201414341402A US2015141636A1 US 20150141636 A1 US20150141636 A1 US 20150141636A1 US 201414341402 A US201414341402 A US 201414341402A US 2015141636 A1 US2015141636 A1 US 2015141636A1
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United States
Prior art keywords
certain embodiments
oligonucleotide
nucleosides
ch
nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US14/341,402
Inventor
Eric E. Swayze
Andrew M. Siwkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US4261908P priority Critical
Priority to PCT/US2009/039557 priority patent/WO2009124295A2/en
Priority to US93615611A priority
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Priority to US14/341,402 priority patent/US20150141636A1/en
Publication of US20150141636A1 publication Critical patent/US20150141636A1/en
Application status is Abandoned legal-status Critical

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