US20130173004A1 - Support device and method for use - Google Patents
Support device and method for use Download PDFInfo
- Publication number
- US20130173004A1 US20130173004A1 US13/773,100 US201313773100A US2013173004A1 US 20130173004 A1 US20130173004 A1 US 20130173004A1 US 201313773100 A US201313773100 A US 201313773100A US 2013173004 A1 US2013173004 A1 US 2013173004A1
- Authority
- US
- United States
- Prior art keywords
- channel
- rigid section
- implant
- target site
- steering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4405—Joints for the spine, e.g. vertebrae, spinal discs for apophyseal or facet joints, i.e. between adjacent spinous or transverse processes
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30331—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementarily-shaped recess, e.g. held by friction fit
- A61F2002/30378—Spherically-shaped protrusion and recess
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- A61F2/02—Prostheses implantable into the body
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Definitions
- a device such as a flexible spinal fusion cage, which can articulate (bend) in such a way is that it will be able to be implanted from a lateral approach into L4-L5 and L5-S1 is disclosed.
- Typical lateral approach fusion implants e.g., Discover XLIF, by NuVasive, Inc., San Diego, Calif.; and the Direct Lateral Interbody Fusion (DLIF) by Medtronic, Inc., Minneapolis, Minn.
- DLIF Direct Lateral Interbody Fusion
- FIGS. 1 a and 1 b illustrate the pelvis and lower spine including the Ilium 2 , sacrum S1, and lower lumbar vertebrae L3, L4 and L5.
- FIGS. 1 a and 1 b show the challenge of gaining lateral access to the L4-L5 and the L5-S1 intervertebral spaces. The position of the Ilium 2 obstructs the direct lateral access pathway.
- FIG. 2 illustrates windows 4 a and 4 b or channels which some doctors create during implantation.
- the windows 4 a and 4 b are created through the Ilium to gain direct fine of site access to the L4-L5 and L5-S1 intervertebral spaces, respectively. This is a highly invasive approach, creates significant tissue damage, particularly to the Ilium and surrounding soft tissue, and requires significant surgical skill.
- the steep approach angle ( 8 a for the L4-L5 intervertebral space and 8 b for the L5-S1 intervertebral space), as measured from a transverse plane along the approach path ( 10 a for the L4-L5 imervertebral space and 10 b for the L5-S1 intervertebral space) of a tissue retractor relative to the location of the fusion site can cause problems, as illustrated in FIGS. 3 and 4 .
- the approach paths 10 a and 10 b pass through the skin surface 12 .
- the tissue retractor used in lateral fusion surgery provides line of site access to the disk space requiring a fusion cage insertion. The tissue retractor holds tissue out of the way of the procedure.
- the tissue retractor is also used to create a working channel to pass tools through, protect neural tissue, and anchor to the superior and inferior vertebral bodies relative the disk space requiring fusion.
- the volume within the pelvis and inferior to the dashed demarcation line 6 along a transverse plane is very hard if not impossible to reach with a direct lateral approach due to the Ilium. Even if the retractors are tilted as shown by the demarcation line 6 , the ability to insert an implant that is the IA length of the end plates of the L4 or L5 vertebral bodies would be very difficult due to obstruction of the Ilium among, other factors.
- a typical lateral fusion cage or implant width 16 is the width of the end plate 18 along the adjacent disk.
- the implant 14 can not turn the corner at the pivot point 20 at the lateral and/or anterior edge of the L5-S1 intervertebral, space.
- the device can be an implantable fixation device, such as a flexible and/or articulatable fusion cage.
- the device can articulate and/or bend so the device can make the turn around the L5-S1 intervertebral space.
- the implant can flex and/or articulate.
- the implant can have hinges and/or be flexible (e.g., have significantly elastic structural components).
- Articulation tools are disclosed that can be used to implant the device.
- the articulation tools can articulate the device and/or allow the device to articulate.
- the connection between the articulation tool and the implant can bend, flex, steer, or combinations thereof.
- the articulation tools can be used to debride or clear out the disk space.
- An oblique curved access tool or device can be used.
- the device can be delivered to the intervertebral space along an oblique approach path, not perpendicular to the spine.
- the oblique approach can provide an access path from lateral skin to the L5-S1 disk space, and can curve tangent to the Ilium.
- a large working channel through the soft tissue can be created.
- the oblique access tool can move soft tissue out of the way to create the working channel.
- the oblique approach can reduce the access-tool-to-disk-space approach angle.
- a biological implant support device for providing orthopedic support can be articulatable or flexible.
- the device can have a first rigid section at a first terminal end of the device.
- the first rigid section can have a first top plate and a first bottom plate.
- the device can have a second rigid section having a second top plate and a second bottom plate.
- the first rigid section can be rotatably attached to the second rigid section.
- the top and bottom plates can be configured to interface with hard tissue.
- a method for inserting a support device to a target site in a spine adjacent to a first vertebra can include creating, a channel through a non-vertebral bone.
- the method can include inserting a first rigid section of the device through the channel and into the target site.
- the method can include inserting a second rigid section of the device through the channel.
- the method can include rotating the second rigid section of the implant with respect to the first rigid section.
- the first rigid section can be hingedly attached to the second rigid section.
- the method can include inserting the second rigid section of the implant into the target site.
- Creating the channel can include drilling the tissue with a flexible drill.
- the non-vertebral bone can be the pelvis, such as the ilium and/or the sacrum.
- a method for inserting an implant to a target site between a first vertebra and a second vertebra can include creating a first channel through the ilium.
- the method can include creating a second channel through the sacrum.
- the first channel can be aligned with the second channel.
- the method can include inserting a first rigid section of the implant through the first channel and the second channel into the target site.
- the method can include rotating a second rigid section of the implant with respect to the first rigid section, wherein the first rigid section is hingedly attached to the second rigid section.
- the method can include inserting the second rigid section of the implant into the target site.
- the second channel can pass through a port formed in vertebral endplate.
- the device can be inserted through the port in the vertebral endplate and articulate as the device is delivered into the target site.
- FIGS. 1 a and 1 b are anterior and lateral views, respectively, of the lower lumbar and sacral spine and pelvis with the Ilium shown in phantom lines in FIG. 1 b.
- FIG. 2 is a lateral view of the lower lumbar spine with windows cut through the Ilium.
- FIGS. 3 and 4 are anterior and lateral views, respectively, of the lower spine and pelvis along with approach paths into the intervertebral spaces.
- FIG. 5 a is an anterior close-up view of the lower spine and pelvis with an approach of a monolithic implant.
- FIG. 5 b illustrates a variation of the implantable device.
- FIGS. 5 c and 5 d illustrate a variation of a method of delivering the device of FIG. 5 b into the L5-S1 space.
- FIGS. 6 through 8 are anterior, perspective and lateral views, respectively, of a variation of the approach path for delivering the implant into the intervertebral space.
- FIGS. 9 a through 9 d illustrate variations of the device in various configurations.
- An x-axis, y-axis and z-axis are also shown for orientation with the x-axis disposed along the longitudinal axis of the device.
- FIGS. 10 a and 10 b illustrate various configurations of a variation of the device in a steering tube with the tube shown as see-through for illustrative purposes.
- FIGS. 10 c through 10 e illustrate various configurations of a variation of the device on steering rails attached to the lateral outside of the device.
- FIGS. 11 a through 11 c illustrate various configurations of a variation of the device on a steering rail attached to the inside of the device.
- FIGS. 12 a through 12 f are cross-sections of various steering rails, or along the length of the same steering rail.
- FIG. 13 illustrates a method for deploying the device into the L5-S1 intervertebral space.
- FIGS. 14 a and 14 b illustrate various configurations of a variation of the device in a steering slide.
- FIGS. 15 a and 15 b are top and side views of a variation of the device with parallel hinges.
- FIG. 16 is a top view of a variation of the device with non-parallel hinges.
- FIGS. 17 a through 17 f are side views of variations of the device.
- FIGS. 18 and 19 are perspective views showing the orientation of variations of living hinges within devices.
- FIGS. 20 a through 20 c are perspective, top and front views, respectively, of a variation of the device in a straight or flat configuration.
- FIGS. 21 a through 21 c are perspective, top and front views, respectively, of the device of FIGS. 20 a through 20 c in an articulated configuration.
- FIGS. 22 a through 22 e are perspective, top and front views, respectively, of a variation of the device in a straight or flat configuration.
- FIGS. 23 a through 23 c are perspective, top and front views, respectively, of the device of FIGS. 22 a through 22 c in an articulated configuration.
- FIG. 24 illustrates the lower spine and pelvis.
- FIGS. 25 through 28 illustrate a variation of a method of delivering the device to a target site.
- FIGS. 29 through 31 illustrate views through the transverse plane from a superior location, the sagittal plane from a lateral location, and the coronal plane from an anterior location, respectively, of a variation of the location of the transosseous deliver channel.
- FIGS. 32 a through 32 d illustrate a superior view of a variation of a method of delivering the device showing the iliac and sacrum, but not the L5-S1 disc or remainder of the spine for illustrative purposes.
- FIGS. 33 a through 33 d illustrate a posterior perspective view of a variation of a method of delivering the device showing the iliac and sacrum, but not the L5-S1 disc or remainder of the spine for illustrative purposes.
- Support or fixation devices and methods for access, controlling (steering) implants, and modifying implants are disclosed.
- the support device disclosed herein can be used to treat one or more osseous structures in the body including the L4-L5 and L5-S1 region of the spine.
- the device can be used with known methods of accessing the vertebrae of the spine such as the L4-L5 and L5-S1 regions with posterior, anterior, or lateral approaches, or combinations thereof.
- the device can be an implantable fixation device, such as a flexible fusion cage.
- the device can be delivered into an intervertebral space, for example, to provide structural support between the adjacent vertebrae.
- the device can fuse the vertebra adjacent to the specific intervertebral space.
- a discectomy can be performed at the target implant site before or during delivery of the implant.
- FIGS. 5 a through 5 c illustrate that the device can be articulatable or flexible.
- the implantable device 10 can be used to support and/or fix structures between adjacent vertebrae, such as between the L4 and L5 vertebrae or between the L5 and S1 vertebrae.
- the implantable device 10 can be articulatable and/or flexible so as to navigate sharp anatomical turns, such as the L4-L5 or L5-S1 intervertebral space.
- the implantable device 10 can be rigidly lockable or can remain flexible or articulatable at all times.
- the implantable device 10 can be rigidly locked for example using a delivery tool, wires, sheaths, guides, or combinations thereof, for example, for additional stability.
- Such surgical delivery tools alone or in combination, may add axial strength and stability before during or after pressing the implantable device 10 into the targeted intervertebral disc space.
- FIG. 5 b illustrates that the implantable device 14 can have first, second, third, and fourth segments 22 a through 22 d .
- Each of the segments 22 a , 22 b , 22 c , and 22 d can be attached to the adjacent segment at a flex point or articulatable hinge 24 a , 24 b , and 24 c , respectively.
- the device 14 can articulate and/or bend at the hinges 24 .
- FIGS. 5 c and 5 d illustrate that the device 14 can be delivered into the L5-S1 intervertebral space.
- the device 14 can make the turn around the L5-S1 intervertebral space, such as at the pivot point 20 , by articulating or flexing.
- FIGS. 6 through 8 shows illustrate a curved implant pathway or approach path 10 c .
- An articulation tool can be used to push (e.g., impact), pull, control or combinations thereof, the implant 14 .
- the implant 14 can articulate and/or flex during delivery.
- the implant can have single or multiple hinges, a flexible shaft, laser slots e.g., in a tube to act as hinges) or combinations thereof.
- the approach path 10 c can be tangential to the medial surface of the Ilium along a portion of the length of the approach path 10 c .
- a portion of the length of the approach path 10 c can be linear and a portion of the length of the approach path 10 c can be curved.
- the entire approach path 10 c can be linear or curved.
- a portion of the length of the approach path 10 c can track (i.e., follow the same shape of) the medial surface of the Ilium.
- the approach path 10 c can contact the medial surface of the Ilium 2 .
- the approach path 10 c can be non-perpendicular or perpendicular to the longitudinal axis 27 of the spine where the approach path 10 c enters the intervertebral space L4-L5 or L5-S1.
- the approach-Ilium gap 26 can be measured between the approach path 10 c and the closest medial surface of the Ilium 2 .
- the approach-Ilium gap 26 can be perpendicular to the approach path 10 c and the Ilium 2 , for example when the approach path 10 c is tracking the medial surface of the Ilium 2 .
- the approach-Ilium gap 26 can be from about (1 mm to about 15 mm along the length of the approach path 10 c where the approach path is tracking the medial surface of the Ilium 2 , more narrowly from about 0 mm to about 10 mm, yet more narrowly from about 2 mm to about 8 mm.
- the approach path 10 c can be curved in all three dimensions (e.g., in the transverse plane, sagittal plane and coronal plane), or any combination thereof and straight in the remaining dimensions.
- FIG. 9 a through 9 d illustrate that variations of hinges 24 a and 24 b between the segments 22 a , 22 b and 22 c can allow the implant 14 to articulate.
- the implant 14 can have controlled angulation or articulation (i.e., with discrete, defined built-in stopping points or stops) or free angulation or articulation (i.e., with no stops).
- FIG. 9 a illustrates that the hinges 24 a and 24 b can be oriented in parallel with the z-axis.
- the hinges can have a single degree of rotational freedom.
- the segments 24 , 24 b and 24 c can articulate by rotating about the z-axis with respect to each other.
- the hinges 24 a and 24 b can be near the top (as shown), near the bottom, in the middle with respect to the y-axis, or combinations thereof of the device 14 .
- FIG. 9 b illustrates that the hinges 24 a and 24 b can be oriented in parallel with the x-axis.
- the segments 24 , 24 b and 24 c can articulate by rotating about the x-axis with respect to each other.
- the hinges 24 a and 24 h can be near the front (as shown), near the rear, in the middle with respect to the z-axis, or combinations thereof of the device 14 .
- FIG. 9 c illustrates that the hinges 24 a and 24 b can be oriented in parallel with the y-axis.
- the segments 24 , 24 b and 24 c can articulate by rotating about the y-axis with respect to each other.
- the hinges 24 a and 24 b can be near the front as shown), near the rear, in the middle with respect to the z-axis, or combinations thereof of the device 14 .
- FIG. 9 d illustrates that the hinges 24 a and 24 b can be ball-in-socket hinges allowing three rotational degrees of freedom, or a combination of the three hinges described hi FIGS. 9 a through 9 c , allowing two or three degrees of freedom.
- the segments 24 , 24 b and 24 c can articulate by rotating about the x-axis, and/or y-axis, and/or z-axis with respect to each other.
- the hinges 24 a and 24 b can be near the front (as shown), near the rear, in the middle with respect to the z-axis, near the top, near the bottom, in the middle with respect to the y-axis (as shown), or combinations thereof of the device 14 .
- the first hinge 24 a can be located in a different location and/or with a different than the second hinge 24 h .
- the first hinge 24 a can be oriented in parallel with the z-axis, allow rotation about the z-axis and be located near the top of the device 14
- the second hinge 24 b can be oriented in parallel with the x-axis, allow rotation about the x-axis, and be located near the middle of the device 14 with respect to the z-axis.
- FIGS. 10 a and 10 b illustrate that the device 14 can have an outer steering sheath or tube 28 .
- the device 14 can be fixed to the steering tube 28 or can slide along the steering tube 28 .
- the steering tube 26 can be articulatable and/or flexible, as shown by the arrow in FIG. 10 b and the various configurations of the tube 28 between FIGS. 10 a and 10 b .
- the articulation or flexion of the steering tube 28 can be controlled, fir example by delivering, controlled tension to tensile control wires in the walls of the steering tube 28 .
- the steering tube 28 can be positioned at the target deployment site.
- the steering tube 28 can be placed in the intervertebral space and can remain in the intervertebral space post-surgery, or the steering tube 28 can be removed from the intervertebral space and the device 14 can be deployed from the tube 28 and the device 14 can be left in the intervertebral space.
- the distal end of the steering, tube 28 can be positioned at the entrance to the intervertebral space and/or rested on the inferior and/or superior vertebral body end plate adjacent to the target intervertebral space.
- the device 14 can then be pushed (e.g., by a plunger) out of the steering tube and into the intervertebral space.
- the steering tube 28 does not have to, but can, enter the intervertebral space.
- FIGS. 10 c through 10 d illustrate that the device 14 can have one or more exterior steering rails, tracks or wires 30 a and 30 b , such as guidewires.
- the rails 30 a and 30 b can slidably or fixedly and releasably engage the external surface of the segments 22 of the device 14 .
- the rails can pass through slots, guides, collars, cuffs or combinations thereof on the exterior of the segments 22 .
- the slots, guides, collars, cuffs or combinations thereof, and/or the rails 30 a and 30 b can be coated or covered with a low-friction (e.g., PTFE) or high-friction (e.g., knurled or toothed surface texturing) material or surface treatment or texture, including any of the materials listed herein.
- the steering rails 30 a and 30 b can be steered or manipulated by applying, a tensile force to tensile cables within the rails, as shown by the arrows in FIGS. 10 d and 10 e , and the flexing from FIGS. 10 c to 10 d .
- the rails 30 a and 30 b can be pre-formed to a specific shape and can be substituted for other rails 30 a and 30 b that can be pre-formed to a different shape to change the direction of delivery.
- FIGS. 11 a through 11 c illustrates that the device 14 can have one or more interior steering rails, guide, tracks or wires 30 , such as guidewires.
- the rails 30 can be positioned through the center or interior of one or more segments 22 of the device 14 .
- the rail 20 can slidably or fixedly and releasably engage an internal surface, such as through a longitudinal guide port or channel 32 , of the segments 22 of the device 14 .
- ports or channels can extend longitudinally through the segments 22 of the device 14 .
- the channels, and/or the rail 30 can be coated, covered or collared, such as with a low-friction (e.g., PTFE) or high-friction (e.g., knurled or toothed surface texturing) material or surface treatment or texture, including any of the materials listed herein.
- the steering rail 30 can be steered or manipulated by applying a tensile force to tensile cables within the rail 30 , as shown by the flexing from FIG. 11 a to 11 c .
- the rail 30 can be pre-formed to a specific shape and can be substituted for one or more other rails 30 that can be pre-formed to a different shape to change the direction of delivery.
- the distal ends of the internal and/or external steering rail or rails 30 can be positioned at the target deployment site.
- the steering, rails 30 can be placed in the intervertebral space and can remain in the intervertebral space post-surgery, or the steering rails 30 can be removed from the intervertebral space and the device 14 can be deployed from the rails 30 and the device 14 can be left in the intervertebral space.
- the distal end of the steering rails 30 can be positioned at the entrance to the intervertebral space and/or rested on the inferior and/or superior vertebral body end plate adjacent to the target intervertebral space.
- the device 14 can then be pushed (e.g., by a plunger) out of the steering, rails 30 and into the intervertebral space.
- the steering rails 30 do not have but can, enter the intervertebral space.
- FIGS. 12 a through 12 f illustrate cross-sections of various rails 30 , or at various lengths along the same rail 30 .
- FIG. 12 a illustrates that the cross-section of the steering rail 30 can be circular.
- FIG. 12 b illustrates that the cross-section of the steering rail 30 can be oval.
- FIG. 12 c illustrates that the cross-section of the steering rail 30 can be multi-ovular (i.e., having, a union of two or more ovals with the same major axis).
- FIG. 12 d illustrates that the cross-section of the steering rail 30 can be the union of rectangles intersecting at right (or another) angle, such as a plus-sign.
- FIG. 12 e illustrates that the cross-section of the steering rail 30 can be hexagonal.
- FIG. 12 a illustrates that the cross-section of the steering rail 30 can be circular.
- FIG. 12 b illustrates that the cross-section of the steering rail 30 can be oval.
- FIG. 12 c illustrates
- the cross-section of the steering rail 30 can be rectangular or square with sharp or rounded (chamfered) edges.
- the cross-section of the steering rail 30 can be triangular, pentagonal, heptagonal, or octagonal.
- the steering rail 30 whether internal or external to the device 14 , can deliver torque around the longitudinal and/or transverse axes of the device.
- the steering rail 30 can have various cross sections at various lengths along the rail 30 .
- the steering rail 30 can guide, pitch, yaw and roll the device 14 into a desired orientation or indication.
- the device 14 can be delivered with one or more internal and/or external rails 30 and/or a sheath 28 or neither.
- FIG. 13 illustrates a device 14 that can be attached to a deployment tool having, a controller handle 34 controllably attached to the internal steering rail 30 .
- the internal steering rail 30 can pass through the device 14 .
- the steering rail 30 can be fixedly attached to the device 14 during the delivery and articulation of the device 14 .
- the device can be steered along or tracking the medial surface of the Ilium 2 .
- the device 14 can then be positioned adjacent to the target site (e.g., the L5-S1 intervertebral space).
- the deployment tool can then release the device 14 from the steering rail 30 and push the device 14 into the target site.
- FIGS. 14 a and 14 b illustrate that the device 14 can be delivered by being pushed along a steering horn, boot, or slide 36 .
- the slide 36 can be similar to the steering tube 28 , except that at least one wall of the slide 36 can be missing or open (e.g., the top wall is not present in the variation of the slide shown) compared with the steering tube 28 .
- the missing wall can be completely open or replaced by one or more steering rails 30 .
- the slide 36 can be used similar to the steering rails 30 anttor steering tube 28 .
- the slide 36 can be steered, flexed or articulated by applying a tensile force to tensile cables within the rails, as shown by the arrow in FIG. 14 b , and the flexing from FIGS. 14 a to 14 b.
- FIGS. 15 a and 15 b illustrate that the device 14 can have six segments 22 a through 22 f and five hinges 24 a through 24 e .
- the segments 22 can be attached to adjacent segments 22 by one or more hinges, tension or steering rails or wires, screws, pins, or combinations thereof.
- the hinges 24 can be pins.
- the segments 22 can be chained together.
- the segments 22 can be identical to each other except for the distal-most segment 22 a and the proximal-most segment 22 f .
- the segments 22 or links can be box-shaped.
- the hinges 24 such as the pins, can be parallel to all or some of the other hinges 24 .
- FIG. 16 illustrates that the hinges 24 can be at acute angles to all or some of the hinges 24 .
- the hinges 24 can be at hinge angles 38 with respect to each other.
- the hinge angle 38 can be measured between the hinge longitudinal axis 40 and the device longitudinal axis 42 .
- the hinge angles 38 can be from about 80° to about 150°, more narrowly from about 90° to about 135°, yet more narrowly from about 95° to about 110°.
- the device 14 can be translated and/or rotated by a handle 34 that can be removably attached to the device 14 .
- the handle 34 can be screwed and/or snapped directly into the proximal end of the device 14 , such as into the proximal-most segment 22 .
- the handle 34 can compress, such as by grabbing or pinching, the proximal end of the device 14 .
- the handle 34 can be a pusher, plunger, ram, or combinations thereof.
- the handle 34 and/or remainder of the deployment tool can be rigid and/or flexible or articulatable. For example, hinged similar to the device 14 .
- the segments 22 are not necessarily connected to each other by hinges.
- the segments 22 can be delivered to the target site individually, or as an unattached line of segments 22 .
- the device 14 can be cylindrical and flexible.
- the implantable device 14 can be fully flexible all the time.
- the device 14 can be mechanically stabilized by the deployment tool, steering wires, sheaths, tubes and guides.
- the tools, wires, sheaths, tubes and guides can provide column stability to press the device 14 into the target site (e.g., intervertebral disc space).
- the device 14 can flexible, and then locked with a tension or steering wire to stop rotational motion of the hinges once the device is delivered to and oriented within the target site.
- the tension wire could be tightened, for example by being tensioned by a nut to create higher friction in each hinge 24 .
- FIGS. 17 a through 17 f illustrate that the device 14 can have a living hinge 44 .
- the living hinge 44 is a length of decreased rigidity and increased flexing, within the body of the device 14 .
- the living hinge 44 can be formed around slots and continuous segments of otherwise tough, durable material.
- the living hinge 44 can be defined be narrowing or thinning in the body of the device 14 , such that the narrowing is sufficient to provide flexibility under reasonable torque.
- the thickness of the unitary body of the device 14 at the living hinge 44 can be narrowed by more than about 85%, or more than about 90%, or more than about 95%, or more than about 97%, or more than about 98.5%.
- the living hinge 44 can have one or more repeated thinnings along the length of the device 14 , as shown in FIGS. 17 a through 17 f.
- FIGS. 17 a and 17 b illustrate that the device 14 bends at the living hinge 44 .
- the living hinges 44 can be made to control the bend and direction of the device 14 .
- the outer surface of the device 14 along the living hinge 44 can be smooth, for example providing low-friction surface for sliding over bone.
- FIGS. 17 a and 17 b illustrate that the living hinge 44 can be along the bottom of the implant device 14 .
- FIG. 17 c illustrates that the living hinge 44 can be along the top of the device 14 .
- FIG. 17 d illustrates that the living hinge 44 can be through the middle or central axis of the device 14 .
- FIG. 17 e illustrates that the living hinge 44 is discontinuous and on opposite sides of the center of the device 44 .
- FIG. 17 f illustrates that the living hinge 44 is at an angle with respect to the longitudinal axis of the device 14 , starting near the bottom of the device 14 and ending near the top of the device 14 .
- FIG. 18 illustrates that the living hinge 42 can be at a non-zero angle to the central longitudinal axis 42 of the device 14 .
- a first length of the living hinge 42 can be at a non-zero angle to a second length of the living hinge 44 .
- FIG. 19 illustrates that the living hinge 44 can be curved.
- the living hinge 44 can curve around the central longitudinal axis 42 of the device 14 .
- FIGS. 20 a through 20 c illustrate that the device can have three segments 22 a , 22 b and 22 c connected by two hinges 24 a and 24 b .
- the device longitudinal axis 42 can be straight or can have a longitudinal radius of curvature 46 .
- the longitudinal radius of curvature 46 can be from about 3 cm to about 100 cm, more narrowly from about 5 cm to about 20 cm, yet more narrowly from about 7 cm to about 15 cm, far example about 15 cm, also for example about 10 cm.
- the support device 14 can have a support device width 11 a , a support device length 11 b and a support device height 11 c .
- the support device width 11 a can be from about 10 mm to 30 mm, or more narrowly 16 mm to about 18 mm.
- the support device length 11 b can be from about 30 mm to 60 mm, or more narrowly from 45 mm to about 55 mm.
- the support device height 11 c can be from about 1 mm to 30 mm, or more narrowly from 8 mm to about 16 mm.
- the device 14 can have an anterior taper or lordosis angle 48 .
- the taper angle 48 can be measured between the plane of the top surface and the plane of the bottom surface of the device 14 .
- the taper angle 48 can be from about 0° parallel top and bottom planes) to about 45°, more narrowly from about 2° to about 20°, yet more narrowly from about 0° to about 12°, yet more narrowly from about 4° to about 10°, yet more narrowly from about 4° to about 8°, for example from about 0°, also for example about 6°.
- the first, second, and third links or segments 22 a , 22 b and 22 c of the flexible implantable device 14 may be separate or connected.
- One or more of the segments 22 can be rigid and/or flexible.
- One or more of the segments 22 can have through-ports or segment ports 50 , such as first, second and third segment ports 50 a , 50 b and 50 c , through the first, second and third segments 22 a , 22 b , and 22 c , respectively.
- the segment ports 50 can extend through part of all of the height of the respective segment 22 or the device 14 from the top to the bottom surface.
- One or more of the segment ports 50 can be partially or completely tilled with a bone ingrowth matrix, bone morphogenic protein, therapeutic agents, any agent or material disclosed herein, or combinations thereof, for example for analgesic effect or to promote bone ingrowth.
- the device 14 can have a surface coating or texturing on the top, and/or bottom, and/or side surfaces, such as lateral teeth 52 , longitudinal or angled teeth, knurling, a coating or matrix to promote bone ingrowth, or combinations thereof.
- the device 14 can have hinge teeth or knuckles 54 .
- the hinge teeth 54 can slide by adjacent hinge teeth 54 to increase lateral stability during articulation and increase range of motion (e.g., a hinge tooth 54 on one segment 22 can slide into the gap between hinge teeth 54 on the adjacent segment 22 during articulation of the device 14 ).
- One or more tension and/or steering wires can be inserted and/or tensioned through guide ports or channels 32 a and 32 b .
- the guide channels 32 a and 32 b can extend longitudinally through some or all of the segments 22 .
- the first segment 22 a and the third segment 22 c can have central vertical holes 82 a and 82 b , respectively.
- the central vertical holes 82 can be attached to a deployment device, screwed to the adjacent tissue (i.e., bone) after delivery, filled with a radiopaque material for visualization or therapeutic or other material listed herein, or combinations thereof.
- FIGS. 21 a through 21 c illustrate that device 14 can articulate.
- the segments 22 can rotate with respect to each other about the hinges 24 , as shown by arrows.
- the first segment 22 a can have a first segment longitudinal axis 42 a .
- the second segment 22 b can have a second segment longitudinal axis 42 b .
- the third segment 22 c can have a third segment longitudinal axis 42 c .
- the respective longitudinal axes can intersect at the adjoining hinge pins 24 .
- the first segment longitudinal axis 42 a can form a first articulation angle 80 a with the second segment longitudinal axis 42 b .
- the second segment longitudinal axis 42 b can form a second articulation angle 80 b with the third segment longitudinal axis 42 c .
- the first and second articulation angles 80 a and 80 b can be the same or different.
- the first and/or second articulation angles 80 a and/or 80 b can be from about 0° to about 90°, more narrowly from about 3° to about 75°, yet more narrowly from about 5° to about 60°, yet more narrowly from about 15° to about 45°.
- FIGS. 22 a through 22 c illustrate that some or all of the distal-most segments 22 a through 22 d can be identical.
- Segments 22 can be added or removed from the device 14 , before during or after deployment to the target site, to increase or decrease the length of the device 14 to best fit the target site.
- the false hinge 24 ′ can be a hinge component that is not attached to the other half of the hinge 24 .
- the hinges 24 can snap together and apart.
- the articulation of each segment 2 . 2 can be limited by the interference fit of a rotational stop 58 on the top and bottom of the adjacent segment 22 .
- the device 14 can have a deployment tool interface, such as the lateral hole 56 , for attaching to the deployment tool.
- FIGS. 23 a through 23 c illustrate that a tensioning or steering wire or rail 30 can be deployed through the channels 32 on each segment. The wire 30 can then be tensioned to articulate and/or lock the device 14 in an articulated configuration.
- any or all elements of the device and/or other devices or apparatuses described herein can be made from, for example, a single or multiple stainless steel alloys, nickel titanium alloys (e.g., Nitinol), cobalt-chrome alloys (e.g., ELGILOY® from Elgin Specialty Metals, Elgin, Ill.; CONICHROME® from Carpenter Metals Corp., Wyomissing, Pa.), nickel-cobalt alloys (e.g., MP35N® from Magellan industrial Trading Company, Inc., Westport, Conn.), molybdenum alloys (e.g., molybdenum TZM alloy, for example as disclosed in International Pub. No. WO 03/082363 A2, published 9 Oct.
- nickel titanium alloys e.g., Nitinol
- cobalt-chrome alloys e.g., ELGILOY® from Elgin Specialty Metals, Elgin, Ill.; CONICHROME®
- tungsten-rhenium alloys for example, as disclosed in International Pub. No. WO 03/082363, polymers such as polyethylene teraphathalate (PET)/polyester (e.g., DACRON® from E. I. Du Pont de Nemours and Company, Wilmington, Del.), polypropylene, (PET), polytetrafluoroethylene (PTFE), expanded PTFE (ePTFE), polyether ketone (PEK), polyether ether ketone (PEEK), poly ether ketone ketone (PEKK) (also poly aryl ether ketone ketone), nylon, polyether-block co-polyamide polymers (e.g.
- PEBAX® from ATOFINA, Paris, France
- aliphatic polyether polyurethanes e.g., TECOFLEX® from Thermedics Polymer Products, Wilmington, Mass.
- PVC polyvinyl chloride
- FEP fluorinated ethylene propylene
- absorbable or resorbable polymers such as polyglycolic acid (PGA), polylactic acid (PLA), polycaprolactone (PCL), polyethyl acrylate (PEA), polydioxanone (PDS), and pseudo-polyamino tyrosine-based acids, extruded collagen, silicone, zinc, echogenic, radioactive, radiopaque materials, a biomaterial (e.g., cadaver tissue, collagen, allograft, autograft, xenograft, bone cement, morselized bone, osteogenic powder, beads of bone) any of the other materials listed herein or combinations thereof.
- radiopaque materials are barium
- any or all elements of the device and/or other devices or apparatuses described herein can be, have, and/or be completely or partially coated with agents and/or a matrix a matrix for cell ingrowth or used with a fabric, for example a covering (not shown) that acts as a matrix for cell ingrowth.
- the matrix and/or fabric can be, for example, polyester (e.g., DACRON® from E. I. Du Pont de Nemours and Company, Wilmington. DE), polypropylene, PTFE, ePTFE, nylon, extruded collagen, silicone or combinations thereof.
- the device and/or elements of the device and/or other devices or apparatuses described herein and/or the fabric can be filled, coated, layered and/or otherwise made with and/or from cements, fillers, glues, and/or an agent delivery matrix known to one having ordinary skill in the art and/or a therapeutic and/or diagnostic agent. Any of these cements and/or fillers and/or glues can be osteogenic and osteoinductive growth factors.
- cements and/or fillers examples include bone chips, demineralized bone matrix (DBM), calcium sulfate, coralline hydroxyapatite, biocoral, tricalcium phosphate, calcium phosphate, polymethyl methacrylate (PMMA), biodegradable ceramics, bioactive glasses, hyaluronic acid, lactoferrin, bone motphogenic proteins (BMPs) such as recombinant human bone morphogenetic proteins (rhBMPs), other materials described herein, or combinations thereof.
- DBM demineralized bone matrix
- PMMA polymethyl methacrylate
- BMPs bone motphogenic proteins
- rhBMPs recombinant human bone morphogenetic proteins
- the agents within these matrices can include any agent disclosed herein or combinations thereof, including, radioactive materials; radiopaque materials; cytogenic agents; cytotoxic agents; cytostatic agents; thrombogenic agents, for example polyurethane, cellulose acetate polymer mixed with bismuth trioxide, and ethylene vinyl alcohol; lubricious, hydrophilic materials; phosphor cholene; anti-inflammatory agents, for example non-steroidal anti-inflammatories (NSAIDs) such as cyclooxygenase-1 (COX-1) inhibitors (e.g., acetylsalicylic acid, for example ASPIRIN® from Bayer AG, Leverkusen, Germany; ibuprofen, for example ADVIL® from Wyeth, Collegeville, Pa.; indomethacin; mefenamic acid), COX-2 inhibitors (e.g., VIOXX® from Merck & Co., Inc., Whitehouse Station, N.J.; CELEBREX
- FIG. 24 illustrates that a straight or curved transosseous delivery channel 94 can be drilled, chiseled, punched, or a combination thereof, through the iliac bone 2 and/or the sacral ala 90 , for example passing through the sacroiliac joint 92 .
- the transosseous delivery channel 94 have a first length or first channel through the iliac 2 and a second length or second channel through the sacrum S1.
- the first length of the transosseous delivery channel 94 can be aligned with the second length of the transosseous delivery channel 94 , for example to form a substantially continuous channel.
- the transosseous delivery channel 94 can have a laterally-located channel entry port 96 laterally outside of the sacral ala 90 and/or iliac bone 2 .
- the transosseous delivery channel 94 can have a channel exit port 98 adjacent to the L5-S1 intervertebral disc space.
- the channel exit port 98 can be in the S1 endplate.
- the channel exit port 98 can be positioned so the circumference of the channel exit port 98 tangentially coincides with or is closely adjacent to (e.g. within about 2 cm, more narrowly within about 1 cm, more narrowly within about 5 mm, yet more narrowly within about 2 mm) with the edge of the S1 vertebral endplate 100 .
- the L5-S1 intervertebral space can be partially or completely void of soft tissue, as shown, for example from a discectomy performed before insertion of the support device 14 .
- the discectomy can be performed by the method and device shown in U.S. Provisional Patent Application No. 61/526,630 filed 23 Aug. 2011, which is incorporated by reference herein in its entirety.
- FIG. 25 illustrates that the support device 14 can be inserted, as shown by arrow 102 , medially through the channel entry port 96 of the transosseous delivery channel 94 .
- the device 14 can be removably and/or articulatably attached to a deployment tool shaft 104 .
- FIG. 26 illustrates that the shaft 104 can be further translated, as shown by arrow 106 , into the transosseous delivery channel 94 .
- the support device 14 can translate toward and into the L5-S1 intervertebral disc space.
- the distal tip of the support device 14 can enter the L5-S1 nutervertebral disc.
- the support device 14 can enter the target site of the L5-S1 intervertebral disc directly from the transosseous delivery channel 94 without passing through any soft tissue between the L5-S1 intervertebral disc and the iliac bone 2 .
- FIG. 27 illustrates that the shaft 104 can be further translated, as shown by arrow 108 , medially through the transosseous delivery channel 94 .
- the device 14 can translate, as shown by arrow 110 , through the L5-S1 intervertebral disc space and the L5 and/or the S1 vertebra.
- the support device 14 can articulate, as shown by arrow 112 .
- One or more of the hinges 24 can rotate, articulating the segments 22 .
- the hinges 24 can be controllably rotatably locked and unlocked, for example, by controls on the handle of the deployment tool (of which the shaft 104 is a part).
- the support device 14 can then be further translated, such as being pushed and/or vibrated (e.g., manually, ultrasonically), for example, medially and laterally, and/or superior and inferiorly, and/or anteriorly and posteriorly.
- the through ports and/or cavities and/or recesses 50 in the device 14 can be partially and/or completely filled bone morphogenic protein, therapeutic agents, other materials listed herein or combinations thereof.
- the support device 14 can deliver a cauterizing electrical energy from the deployment tool.
- the support device 14 and shaft 104 can have one or more longitudinal lumens that can be used to irrigate (e.g., with analgesic agents, saline, anesthetic agents, bone morphogenic proteins, visualization agents, other agents described herein, or combinations thereof) and/or aspirate (e.g., to remove irrigated material and/or debris) the target site (e.g., the L5-S1 intervertebral disc space).
- irrigate e.g., with analgesic agents, saline, anesthetic agents, bone morphogenic proteins, visualization agents, other agents described herein, or combinations thereof
- aspirate e.g., to remove irrigated material and/or debris
- the target site e.g., the L5-S1 intervertebral disc space
- FIG. 28 illustrates that before, during or after the support device 14 is positioned in the L5-S1 intervertebral space, the shaft 104 can detach from the support device 14 and be translated laterally, as shown by arrow 114 , from the L5-S1 intervertebral disc space and the transosseous delivery channel 94 .
- the deployment tool shaft 104 can remove or reposition the support device 14 , or leave the support device 14 in place in the L5-S1 space.
- the method shown in FIGS. 25 through 28 can be repeated to deliver multiple support devices 14 to one or more intervertebral spaces.
- one, two, three or more support devices 14 can be positioned in the L4-L5 intervertebral space and/or the L5-S1 intervertebral space.
- the one, two, three or more support devices 14 positioned in the L4-L5 and/or L5-S1 intervertebral spaces can mechanically support the adjacent vertebrae and/or fix the adjacent vertebrae to each other. Bone ingrowth can occur through the through ports 50 , for example fusing the support devices 14 to the respective surrounding vertebrae.
- FIGS. 29 through 31 illustrate that the transosseous delivery channel 94 can have a coronal delivery angle 120 measured to the coronal plane 122 , a sagittal delivery angle 124 measured to the sagittal plane 126 , and a transverse delivery angle 128 measured to the transverse plane 130 .
- the coronal delivery angle 120 can be from about 0° to about 25°, for example about 12′.
- the sagittal delivery angle 124 can be from about 65° to about 90°, for example about 75°.
- the transverse delivery angle 128 can be from about 0° to about 20°, for example about 10°.
- the support device 14 and shaft 104 can be configured so the support device 14 can exit the channel exit port 98 (e.g., directly into the L5-S1 intervertebral disc) and articulate sufficiently to enter and pass through all or a significant portion (e.g., more than about 40%, yet more narrowly more than about 50%, yet more narrowly more than about 75%) of the width of the L5-S1 intervertebral space.
- the channel exit port 98 e.g., directly into the L5-S1 intervertebral disc
- a significant portion e.g., more than about 40%, yet more narrowly more than about 50%, yet more narrowly more than about 75%) of the width of the L5-S1 intervertebral space.
- FIGS. 30 and 31 show one or both femurs 132 for illustrative purposes.
- FIGS. 32 a through 32 d , and separately FIGS. 33 a through 33 c illustrate the deployment of the support device 14 into the L5-S1 intervertebral disc space target site, as described for FIGS. 24-27 .
- the support device 14 can be delivered to a complete or partial discectomy target site 138 in the L5-S1 space.
- FIG. 33 d illustrates the shall 104 can be rotated, as shown by arrow 134 , about the longitudinal axis of the shaft before during or after the support device 14 is positioned in the L5-S1 intervertebral disc space target site.
- the support device 14 can rotate, as shown by arrow 136 , in the L5-S1 intervertebral disc space, for example to control and position the support device 14 to an angular orientation in the transverse plane 130 .
- Any elements described herein as singular can be pluralized (i.e., anything, described as “one” can be more than one).
- Any species element of a genus element can have the characteristics or elements of any other species element of that genus.
- the above-described configurations, elements or complete assemblies and methods and their elements for carrying out the invention, and variations of aspects of the invention can be combined and modified with each other in any combination.
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Abstract
Devices and methods for orthopedic support are disclosed. The device can have a first rigid section hingedly attached to a second rigid section. The device can be curved or rotated around obstructions along an access path to a target site. The device can be delivered to an intervertebral location in a patient.
Description
- This application is a continuation of PCT Application No. PCT/US2011/048992, filed 24 Aug. 2011, which claims priority to U.S. Provisional Patent Application No. 61/376,626, filed 24 Aug. 2010, and to U.S. Provisional Patent Application No. 61/526,630, filed 23 Aug. 2011, all of which are incorporated by reference herein in their entireties.
- 1. Field of the Invention
- A device, such as a flexible spinal fusion cage, which can articulate (bend) in such a way is that it will be able to be implanted from a lateral approach into L4-L5 and L5-S1 is disclosed.
- 2. Description of the Related Art
- Typical lateral approach fusion implants (e.g., Discover XLIF, by NuVasive, Inc., San Diego, Calif.; and the Direct Lateral Interbody Fusion (DLIF) by Medtronic, Inc., Minneapolis, Minn.) are not able to implant their fusion cages for two reasons.
- First, boney obstacles can impair access.
FIGS. 1 a and 1 b illustrate the pelvis and lower spine including theIlium 2, sacrum S1, and lower lumbar vertebrae L3, L4 and L5.FIGS. 1 a and 1 b show the challenge of gaining lateral access to the L4-L5 and the L5-S1 intervertebral spaces. The position of the Ilium 2 obstructs the direct lateral access pathway. -
FIG. 2 illustrateswindows windows - Second, the steep approach angle (8 a for the L4-L5 intervertebral space and 8 b for the L5-S1 intervertebral space), as measured from a transverse plane along the approach path (10 a for the L4-L5 imervertebral space and 10 b for the L5-S1 intervertebral space) of a tissue retractor relative to the location of the fusion site, can cause problems, as illustrated in
FIGS. 3 and 4 . Theapproach paths skin surface 12. The tissue retractor used in lateral fusion surgery provides line of site access to the disk space requiring a fusion cage insertion. The tissue retractor holds tissue out of the way of the procedure. The tissue retractor is also used to create a working channel to pass tools through, protect neural tissue, and anchor to the superior and inferior vertebral bodies relative the disk space requiring fusion. The volume within the pelvis and inferior to thedashed demarcation line 6 along a transverse plane is very hard if not impossible to reach with a direct lateral approach due to the Ilium. Even if the retractors are tilted as shown by thedemarcation line 6, the ability to insert an implant that is the IA length of the end plates of the L4 or L5 vertebral bodies would be very difficult due to obstruction of the Ilium among, other factors. - Furthermore, with the retractor positioned along the
approach path inflexible fusion cage 14 or implant into the L5-S1 intervertebral space difficult if not virtually impossible due to obstruction of the surrounding hard and soft tissue, as illustrated byFIG. 5 a. A typical lateral fusion cage orimplant width 16 is the width of theend plate 18 along the adjacent disk. Theimplant 14 can not turn the corner at thepivot point 20 at the lateral and/or anterior edge of the L5-S1 intervertebral, space. - Support or fixation devices and methods for access, controlling (e.g., steering or rotating, and driving or translating) implants, and modifying the configuration of implants are disclosed. The device can be an implantable fixation device, such as a flexible and/or articulatable fusion cage. The device can articulate and/or bend so the device can make the turn around the L5-S1 intervertebral space. The implant can flex and/or articulate. For example, the implant can have hinges and/or be flexible (e.g., have significantly elastic structural components).
- Articulation tools are disclosed that can be used to implant the device. The articulation tools can articulate the device and/or allow the device to articulate. For example, the connection between the articulation tool and the implant can bend, flex, steer, or combinations thereof. The articulation tools can be used to debride or clear out the disk space.
- An oblique curved access tool or device can be used. The device can be delivered to the intervertebral space along an oblique approach path, not perpendicular to the spine. The oblique approach can provide an access path from lateral skin to the L5-S1 disk space, and can curve tangent to the Ilium. A large working channel through the soft tissue can be created. The oblique access tool can move soft tissue out of the way to create the working channel. The oblique approach can reduce the access-tool-to-disk-space approach angle.
- A biological implant support device for providing orthopedic support is disclosed. The device can be articulatable or flexible. The device can have a first rigid section at a first terminal end of the device. The first rigid section can have a first top plate and a first bottom plate. The device can have a second rigid section having a second top plate and a second bottom plate. The first rigid section can be rotatably attached to the second rigid section. The top and bottom plates can be configured to interface with hard tissue.
- A method for inserting a support device to a target site in a spine adjacent to a first vertebra is disclosed. The method can include creating, a channel through a non-vertebral bone. The method can include inserting a first rigid section of the device through the channel and into the target site. The method can include inserting a second rigid section of the device through the channel. The method can include rotating the second rigid section of the implant with respect to the first rigid section. The first rigid section can be hingedly attached to the second rigid section. The method can include inserting the second rigid section of the implant into the target site.
- Creating the channel can include drilling the tissue with a flexible drill. The non-vertebral bone can be the pelvis, such as the ilium and/or the sacrum.
- A method for inserting an implant to a target site between a first vertebra and a second vertebra is disclosed. The method can include creating a first channel through the ilium. The method can include creating a second channel through the sacrum. The first channel can be aligned with the second channel. The method can include inserting a first rigid section of the implant through the first channel and the second channel into the target site. The method can include rotating a second rigid section of the implant with respect to the first rigid section, wherein the first rigid section is hingedly attached to the second rigid section. The method can include inserting the second rigid section of the implant into the target site. The second channel can pass through a port formed in vertebral endplate. The device can be inserted through the port in the vertebral endplate and articulate as the device is delivered into the target site.
-
FIGS. 1 a and 1 b are anterior and lateral views, respectively, of the lower lumbar and sacral spine and pelvis with the Ilium shown in phantom lines inFIG. 1 b. -
FIG. 2 is a lateral view of the lower lumbar spine with windows cut through the Ilium. -
FIGS. 3 and 4 are anterior and lateral views, respectively, of the lower spine and pelvis along with approach paths into the intervertebral spaces. -
FIG. 5 a is an anterior close-up view of the lower spine and pelvis with an approach of a monolithic implant. -
FIG. 5 b illustrates a variation of the implantable device. -
FIGS. 5 c and 5 d illustrate a variation of a method of delivering the device ofFIG. 5 b into the L5-S1 space. -
FIGS. 6 through 8 are anterior, perspective and lateral views, respectively, of a variation of the approach path for delivering the implant into the intervertebral space. -
FIGS. 9 a through 9 d illustrate variations of the device in various configurations. An x-axis, y-axis and z-axis are also shown for orientation with the x-axis disposed along the longitudinal axis of the device. -
FIGS. 10 a and 10 b illustrate various configurations of a variation of the device in a steering tube with the tube shown as see-through for illustrative purposes. -
FIGS. 10 c through 10 e illustrate various configurations of a variation of the device on steering rails attached to the lateral outside of the device. -
FIGS. 11 a through 11 c illustrate various configurations of a variation of the device on a steering rail attached to the inside of the device. -
FIGS. 12 a through 12 f are cross-sections of various steering rails, or along the length of the same steering rail. -
FIG. 13 illustrates a method for deploying the device into the L5-S1 intervertebral space. -
FIGS. 14 a and 14 b illustrate various configurations of a variation of the device in a steering slide. -
FIGS. 15 a and 15 b are top and side views of a variation of the device with parallel hinges. -
FIG. 16 is a top view of a variation of the device with non-parallel hinges. -
FIGS. 17 a through 17 f are side views of variations of the device. -
FIGS. 18 and 19 are perspective views showing the orientation of variations of living hinges within devices. -
FIGS. 20 a through 20 c are perspective, top and front views, respectively, of a variation of the device in a straight or flat configuration. -
FIGS. 21 a through 21 c are perspective, top and front views, respectively, of the device ofFIGS. 20 a through 20 c in an articulated configuration. -
FIGS. 22 a through 22 e are perspective, top and front views, respectively, of a variation of the device in a straight or flat configuration. -
FIGS. 23 a through 23 c are perspective, top and front views, respectively, of the device ofFIGS. 22 a through 22 c in an articulated configuration. -
FIG. 24 illustrates the lower spine and pelvis. -
FIGS. 25 through 28 illustrate a variation of a method of delivering the device to a target site. -
FIGS. 29 through 31 illustrate views through the transverse plane from a superior location, the sagittal plane from a lateral location, and the coronal plane from an anterior location, respectively, of a variation of the location of the transosseous deliver channel. -
FIGS. 32 a through 32 d illustrate a superior view of a variation of a method of delivering the device showing the iliac and sacrum, but not the L5-S1 disc or remainder of the spine for illustrative purposes. -
FIGS. 33 a through 33 d illustrate a posterior perspective view of a variation of a method of delivering the device showing the iliac and sacrum, but not the L5-S1 disc or remainder of the spine for illustrative purposes. - Support or fixation devices and methods for access, controlling (steering) implants, and modifying implants are disclosed. The support device disclosed herein can be used to treat one or more osseous structures in the body including the L4-L5 and L5-S1 region of the spine. The device can be used with known methods of accessing the vertebrae of the spine such as the L4-L5 and L5-S1 regions with posterior, anterior, or lateral approaches, or combinations thereof.
- The device can be an implantable fixation device, such as a flexible fusion cage. The device can be delivered into an intervertebral space, for example, to provide structural support between the adjacent vertebrae. The device can fuse the vertebra adjacent to the specific intervertebral space. A discectomy can be performed at the target implant site before or during delivery of the implant.
-
FIGS. 5 a through 5 c illustrate that the device can be articulatable or flexible. The implantable device 10 can be used to support and/or fix structures between adjacent vertebrae, such as between the L4 and L5 vertebrae or between the L5 and S1 vertebrae. The implantable device 10 can be articulatable and/or flexible so as to navigate sharp anatomical turns, such as the L4-L5 or L5-S1 intervertebral space. The implantable device 10 can be rigidly lockable or can remain flexible or articulatable at all times. The implantable device 10 can be rigidly locked for example using a delivery tool, wires, sheaths, guides, or combinations thereof, for example, for additional stability. Such surgical delivery tools, alone or in combination, may add axial strength and stability before during or after pressing the implantable device 10 into the targeted intervertebral disc space. -
FIG. 5 b illustrates that theimplantable device 14 can have first, second, third, andfourth segments 22 a through 22 d. Each of thesegments device 14 can articulate and/or bend at the hinges 24. -
FIGS. 5 c and 5 d illustrate that thedevice 14 can be delivered into the L5-S1 intervertebral space. Thedevice 14 can make the turn around the L5-S1 intervertebral space, such as at thepivot point 20, by articulating or flexing. -
FIGS. 6 through 8 shows illustrate a curved implant pathway orapproach path 10 c. An articulation tool can be used to push (e.g., impact), pull, control or combinations thereof, theimplant 14. Theimplant 14 can articulate and/or flex during delivery. The implant can have single or multiple hinges, a flexible shaft, laser slots e.g., in a tube to act as hinges) or combinations thereof. - The
approach path 10 c can be tangential to the medial surface of the Ilium along a portion of the length of theapproach path 10 c. A portion of the length of theapproach path 10 c can be linear and a portion of the length of theapproach path 10 c can be curved. Theentire approach path 10 c can be linear or curved. A portion of the length of theapproach path 10 c can track (i.e., follow the same shape of) the medial surface of the Ilium. Theapproach path 10 c can contact the medial surface of theIlium 2. Theapproach path 10 c can be non-perpendicular or perpendicular to thelongitudinal axis 27 of the spine where theapproach path 10 c enters the intervertebral space L4-L5 or L5-S1. - The approach-
Ilium gap 26 can be measured between theapproach path 10 c and the closest medial surface of theIlium 2. The approach-Ilium gap 26 can be perpendicular to theapproach path 10 c and theIlium 2, for example when theapproach path 10 c is tracking the medial surface of theIlium 2. The approach-Ilium gap 26 can be from about (1 mm to about 15 mm along the length of theapproach path 10 c where the approach path is tracking the medial surface of theIlium 2, more narrowly from about 0 mm to about 10 mm, yet more narrowly from about 2 mm to about 8 mm. - The
approach path 10 c can be curved in all three dimensions (e.g., in the transverse plane, sagittal plane and coronal plane), or any combination thereof and straight in the remaining dimensions. -
FIG. 9 a through 9 d illustrate that variations ofhinges segments implant 14 to articulate. Theimplant 14 can have controlled angulation or articulation (i.e., with discrete, defined built-in stopping points or stops) or free angulation or articulation (i.e., with no stops). -
FIG. 9 a illustrates that thehinges segments device 14. -
FIG. 9 b illustrates that thehinges segments device 14. -
FIG. 9 c illustrates that thehinges segments device 14. -
FIG. 9 d illustrates that thehinges FIGS. 9 a through 9 c, allowing two or three degrees of freedom. Thesegments device 14. - The
first hinge 24 a can be located in a different location and/or with a different than the second hinge 24 h. For example, thefirst hinge 24 a can be oriented in parallel with the z-axis, allow rotation about the z-axis and be located near the top of thedevice 14, and thesecond hinge 24 b can be oriented in parallel with the x-axis, allow rotation about the x-axis, and be located near the middle of thedevice 14 with respect to the z-axis. -
FIGS. 10 a and 10 b illustrate that thedevice 14 can have an outer steering sheath ortube 28. Thedevice 14 can be fixed to thesteering tube 28 or can slide along the steeringtube 28. The steeringtube 26 can be articulatable and/or flexible, as shown by the arrow inFIG. 10 b and the various configurations of thetube 28 betweenFIGS. 10 a and 10 b. The articulation or flexion of the steeringtube 28 can be controlled, fir example by delivering, controlled tension to tensile control wires in the walls of the steeringtube 28. - The steering
tube 28 can be positioned at the target deployment site. For example, the steeringtube 28 can be placed in the intervertebral space and can remain in the intervertebral space post-surgery, or the steeringtube 28 can be removed from the intervertebral space and thedevice 14 can be deployed from thetube 28 and thedevice 14 can be left in the intervertebral space. - Also for example, the distal end of the steering,
tube 28 can be positioned at the entrance to the intervertebral space and/or rested on the inferior and/or superior vertebral body end plate adjacent to the target intervertebral space. Thedevice 14 can then be pushed (e.g., by a plunger) out of the steering tube and into the intervertebral space. The steeringtube 28 does not have to, but can, enter the intervertebral space. -
FIGS. 10 c through 10 d illustrate that thedevice 14 can have one or more exterior steering rails, tracks orwires rails device 14. For example, the rails can pass through slots, guides, collars, cuffs or combinations thereof on the exterior of the segments 22. The slots, guides, collars, cuffs or combinations thereof, and/or therails FIGS. 10 d and 10 e, and the flexing fromFIGS. 10 c to 10 d. Therails other rails -
FIGS. 11 a through 11 c illustrates that thedevice 14 can have one or more interior steering rails, guide, tracks orwires 30, such as guidewires. Therails 30 can be positioned through the center or interior of one or more segments 22 of thedevice 14. Therail 20 can slidably or fixedly and releasably engage an internal surface, such as through a longitudinal guide port orchannel 32, of the segments 22 of thedevice 14. For example, ports or channels can extend longitudinally through the segments 22 of thedevice 14. The channels, and/or therail 30 can be coated, covered or collared, such as with a low-friction (e.g., PTFE) or high-friction (e.g., knurled or toothed surface texturing) material or surface treatment or texture, including any of the materials listed herein. The steeringrail 30 can be steered or manipulated by applying a tensile force to tensile cables within therail 30, as shown by the flexing fromFIG. 11 a to 11 c. Therail 30 can be pre-formed to a specific shape and can be substituted for one or moreother rails 30 that can be pre-formed to a different shape to change the direction of delivery. - The distal ends of the internal and/or external steering rail or rails 30 can be positioned at the target deployment site. For example, the steering, rails 30 can be placed in the intervertebral space and can remain in the intervertebral space post-surgery, or the steering rails 30 can be removed from the intervertebral space and the
device 14 can be deployed from therails 30 and thedevice 14 can be left in the intervertebral space. - Also for example, the distal end of the steering rails 30 can be positioned at the entrance to the intervertebral space and/or rested on the inferior and/or superior vertebral body end plate adjacent to the target intervertebral space. The
device 14 can then be pushed (e.g., by a plunger) out of the steering, rails 30 and into the intervertebral space. The steering rails 30 do not have but can, enter the intervertebral space. -
FIGS. 12 a through 12 f illustrate cross-sections ofvarious rails 30, or at various lengths along thesame rail 30.FIG. 12 a illustrates that the cross-section of thesteering rail 30 can be circular.FIG. 12 b illustrates that the cross-section of thesteering rail 30 can be oval.FIG. 12 c illustrates that the cross-section of thesteering rail 30 can be multi-ovular (i.e., having, a union of two or more ovals with the same major axis).FIG. 12 d illustrates that the cross-section of thesteering rail 30 can be the union of rectangles intersecting at right (or another) angle, such as a plus-sign.FIG. 12 e illustrates that the cross-section of thesteering rail 30 can be hexagonal.FIG. 12 f illustrates that the cross-section of thesteering rail 30 can be rectangular or square with sharp or rounded (chamfered) edges. The cross-section of thesteering rail 30 can be triangular, pentagonal, heptagonal, or octagonal. The steeringrail 30, whether internal or external to thedevice 14, can deliver torque around the longitudinal and/or transverse axes of the device. The steeringrail 30 can have various cross sections at various lengths along therail 30. The steeringrail 30 can guide, pitch, yaw and roll thedevice 14 into a desired orientation or indication. Thedevice 14 can be delivered with one or more internal and/orexternal rails 30 and/or asheath 28 or neither. -
FIG. 13 illustrates adevice 14 that can be attached to a deployment tool having, acontroller handle 34 controllably attached to theinternal steering rail 30. Theinternal steering rail 30 can pass through thedevice 14. The steeringrail 30 can be fixedly attached to thedevice 14 during the delivery and articulation of thedevice 14. The device can be steered along or tracking the medial surface of theIlium 2. Thedevice 14 can then be positioned adjacent to the target site (e.g., the L5-S1 intervertebral space). The deployment tool can then release thedevice 14 from the steeringrail 30 and push thedevice 14 into the target site. -
FIGS. 14 a and 14 b illustrate that thedevice 14 can be delivered by being pushed along a steering horn, boot, or slide 36. Theslide 36 can be similar to thesteering tube 28, except that at least one wall of theslide 36 can be missing or open (e.g., the top wall is not present in the variation of the slide shown) compared with the steeringtube 28. The missing wall can be completely open or replaced by one or more steering rails 30. Theslide 36 can be used similar to the steering rails 30anttor steering tube 28. Theslide 36 can be steered, flexed or articulated by applying a tensile force to tensile cables within the rails, as shown by the arrow inFIG. 14 b, and the flexing fromFIGS. 14 a to 14 b. -
FIGS. 15 a and 15 b illustrate that thedevice 14 can have sixsegments 22 a through 22 f and five hinges 24 a through 24 e. The segments 22 can be attached to adjacent segments 22 by one or more hinges, tension or steering rails or wires, screws, pins, or combinations thereof. The hinges 24 can be pins. The segments 22 can be chained together. The segments 22 can be identical to each other except for thedistal-most segment 22 a and theproximal-most segment 22 f. The segments 22 or links can be box-shaped. The hinges 24, such as the pins, can be parallel to all or some of the other hinges 24. -
FIG. 16 illustrates that thehinges 24 can be at acute angles to all or some of the hinges 24. The hinges 24 can be at hinge angles 38 with respect to each other. Thehinge angle 38 can be measured between the hingelongitudinal axis 40 and the devicelongitudinal axis 42. The hinge angles 38 can be from about 80° to about 150°, more narrowly from about 90° to about 135°, yet more narrowly from about 95° to about 110°. - The
device 14 can be translated and/or rotated by ahandle 34 that can be removably attached to thedevice 14. Thehandle 34 can be screwed and/or snapped directly into the proximal end of thedevice 14, such as into the proximal-most segment 22. Thehandle 34 can compress, such as by grabbing or pinching, the proximal end of thedevice 14. Thehandle 34 can be a pusher, plunger, ram, or combinations thereof. Thehandle 34 and/or remainder of the deployment tool can be rigid and/or flexible or articulatable. For example, hinged similar to thedevice 14. - The segments 22 are not necessarily connected to each other by hinges. The segments 22 can be delivered to the target site individually, or as an unattached line of segments 22.
- The
device 14 can be cylindrical and flexible. Theimplantable device 14 can be fully flexible all the time. Thedevice 14 can be mechanically stabilized by the deployment tool, steering wires, sheaths, tubes and guides. For example, the tools, wires, sheaths, tubes and guides can provide column stability to press thedevice 14 into the target site (e.g., intervertebral disc space). - The
device 14 can flexible, and then locked with a tension or steering wire to stop rotational motion of the hinges once the device is delivered to and oriented within the target site. The tension wire could be tightened, for example by being tensioned by a nut to create higher friction in eachhinge 24. -
FIGS. 17 a through 17 f illustrate that thedevice 14 can have aliving hinge 44. The livinghinge 44 is a length of decreased rigidity and increased flexing, within the body of thedevice 14. The livinghinge 44 can be formed around slots and continuous segments of otherwise tough, durable material. The livinghinge 44 can be defined be narrowing or thinning in the body of thedevice 14, such that the narrowing is sufficient to provide flexibility under reasonable torque. For example, the thickness of the unitary body of thedevice 14 at the livinghinge 44 can be narrowed by more than about 85%, or more than about 90%, or more than about 95%, or more than about 97%, or more than about 98.5%. The livinghinge 44 can have one or more repeated thinnings along the length of thedevice 14, as shown inFIGS. 17 a through 17 f. -
FIGS. 17 a and 17 b illustrate that thedevice 14 bends at the livinghinge 44. The living hinges 44 can be made to control the bend and direction of thedevice 14. The outer surface of thedevice 14 along the livinghinge 44 can be smooth, for example providing low-friction surface for sliding over bone. -
FIGS. 17 a and 17 b illustrate that the livinghinge 44 can be along the bottom of theimplant device 14.FIG. 17 c illustrates that the livinghinge 44 can be along the top of thedevice 14.FIG. 17 d illustrates that the livinghinge 44 can be through the middle or central axis of thedevice 14.FIG. 17 e illustrates that the livinghinge 44 is discontinuous and on opposite sides of the center of thedevice 44.FIG. 17 f illustrates that the livinghinge 44 is at an angle with respect to the longitudinal axis of thedevice 14, starting near the bottom of thedevice 14 and ending near the top of thedevice 14. -
FIG. 18 illustrates that the livinghinge 42 can be at a non-zero angle to the centrallongitudinal axis 42 of thedevice 14. A first length of the livinghinge 42 can be at a non-zero angle to a second length of the livinghinge 44. -
FIG. 19 illustrates that the livinghinge 44 can be curved. The livinghinge 44 can curve around the centrallongitudinal axis 42 of thedevice 14. -
FIGS. 20 a through 20 c illustrate that the device can have threesegments hinges longitudinal axis 42 can be straight or can have a longitudinal radius ofcurvature 46. The longitudinal radius ofcurvature 46 can be from about 3 cm to about 100 cm, more narrowly from about 5 cm to about 20 cm, yet more narrowly from about 7 cm to about 15 cm, far example about 15 cm, also for example about 10 cm. - The
support device 14 can have asupport device width 11 a, asupport device length 11 b and asupport device height 11 c. Thesupport device width 11 a can be from about 10 mm to 30 mm, or more narrowly 16 mm to about 18 mm. Thesupport device length 11 b can be from about 30 mm to 60 mm, or more narrowly from 45 mm to about 55 mm. Thesupport device height 11 c can be from about 1 mm to 30 mm, or more narrowly from 8 mm to about 16 mm. - The
device 14 can have an anterior taper orlordosis angle 48. Thetaper angle 48 can be measured between the plane of the top surface and the plane of the bottom surface of thedevice 14. Thetaper angle 48 can be from about 0° parallel top and bottom planes) to about 45°, more narrowly from about 2° to about 20°, yet more narrowly from about 0° to about 12°, yet more narrowly from about 4° to about 10°, yet more narrowly from about 4° to about 8°, for example from about 0°, also for example about 6°. - The first, second, and third links or
segments implantable device 14 may be separate or connected. One or more of the segments 22 can be rigid and/or flexible. One or more of the segments 22 can have through-ports orsegment ports 50, such as first, second andthird segment ports third segments segment ports 50 can extend through part of all of the height of the respective segment 22 or thedevice 14 from the top to the bottom surface. One or more of thesegment ports 50 can be partially or completely tilled with a bone ingrowth matrix, bone morphogenic protein, therapeutic agents, any agent or material disclosed herein, or combinations thereof, for example for analgesic effect or to promote bone ingrowth. - The
device 14 can have a surface coating or texturing on the top, and/or bottom, and/or side surfaces, such aslateral teeth 52, longitudinal or angled teeth, knurling, a coating or matrix to promote bone ingrowth, or combinations thereof. - The
device 14 can have hinge teeth orknuckles 54. Thehinge teeth 54 can slide byadjacent hinge teeth 54 to increase lateral stability during articulation and increase range of motion (e.g., ahinge tooth 54 on one segment 22 can slide into the gap betweenhinge teeth 54 on the adjacent segment 22 during articulation of the device 14). - One or more tension and/or steering wires can be inserted and/or tensioned through guide ports or
channels guide channels - The
first segment 22 a and thethird segment 22 c can have centralvertical holes -
FIGS. 21 a through 21 c illustrate thatdevice 14 can articulate. The segments 22 can rotate with respect to each other about thehinges 24, as shown by arrows. - The
first segment 22 a can have a first segmentlongitudinal axis 42 a. Thesecond segment 22 b can have a second segmentlongitudinal axis 42 b. Thethird segment 22 c can have a third segmentlongitudinal axis 42 c. The respective longitudinal axes can intersect at the adjoining hinge pins 24. The first segmentlongitudinal axis 42 a can form afirst articulation angle 80 a with the second segmentlongitudinal axis 42 b. The second segmentlongitudinal axis 42 b can form asecond articulation angle 80 b with the third segmentlongitudinal axis 42 c. The first and second articulation angles 80 a and 80 b can be the same or different. When the device is in an articulated configuration, the first and/or second articulation angles 80 a and/or 80 b can be from about 0° to about 90°, more narrowly from about 3° to about 75°, yet more narrowly from about 5° to about 60°, yet more narrowly from about 15° to about 45°. -
FIGS. 22 a through 22 c illustrate that some or all of thedistal-most segments 22 a through 22 d can be identical. Segments 22 can be added or removed from thedevice 14, before during or after deployment to the target site, to increase or decrease the length of thedevice 14 to best fit the target site. Thefalse hinge 24′ can be a hinge component that is not attached to the other half of thehinge 24. The hinges 24 can snap together and apart. The articulation of each segment 2.2 can be limited by the interference fit of arotational stop 58 on the top and bottom of the adjacent segment 22. - The
device 14 can have a deployment tool interface, such as thelateral hole 56, for attaching to the deployment tool. -
FIGS. 23 a through 23 c illustrate that a tensioning or steering wire orrail 30 can be deployed through thechannels 32 on each segment. Thewire 30 can then be tensioned to articulate and/or lock thedevice 14 in an articulated configuration. - PCT Application No. PCT/US 11/00974 filed 27 May 2011 which claims priority to U.S. Provisional App. No. 61/349,151 filed 27 May 2010 are both herein incorporated by reference in their entireties.
- Any or all elements of the device and/or other devices or apparatuses described herein can be made from, for example, a single or multiple stainless steel alloys, nickel titanium alloys (e.g., Nitinol), cobalt-chrome alloys (e.g., ELGILOY® from Elgin Specialty Metals, Elgin, Ill.; CONICHROME® from Carpenter Metals Corp., Wyomissing, Pa.), nickel-cobalt alloys (e.g., MP35N® from Magellan industrial Trading Company, Inc., Westport, Conn.), molybdenum alloys (e.g., molybdenum TZM alloy, for example as disclosed in International Pub. No. WO 03/082363 A2, published 9 Oct. 2003, which is herein incorporated by reference in its entirety), tungsten-rhenium alloys, for example, as disclosed in International Pub. No. WO 03/082363, polymers such as polyethylene teraphathalate (PET)/polyester (e.g., DACRON® from E. I. Du Pont de Nemours and Company, Wilmington, Del.), polypropylene, (PET), polytetrafluoroethylene (PTFE), expanded PTFE (ePTFE), polyether ketone (PEK), polyether ether ketone (PEEK), poly ether ketone ketone (PEKK) (also poly aryl ether ketone ketone), nylon, polyether-block co-polyamide polymers (e.g. PEBAX® from ATOFINA, Paris, France), aliphatic polyether polyurethanes (e.g., TECOFLEX® from Thermedics Polymer Products, Wilmington, Mass.), polyvinyl chloride (PVC), polyurethane, thermoplastic, fluorinated ethylene propylene (FEP), absorbable or resorbable polymers such as polyglycolic acid (PGA), polylactic acid (PLA), polycaprolactone (PCL), polyethyl acrylate (PEA), polydioxanone (PDS), and pseudo-polyamino tyrosine-based acids, extruded collagen, silicone, zinc, echogenic, radioactive, radiopaque materials, a biomaterial (e.g., cadaver tissue, collagen, allograft, autograft, xenograft, bone cement, morselized bone, osteogenic powder, beads of bone) any of the other materials listed herein or combinations thereof. Examples of radiopaque materials are barium sulfate, zinc oxide, titanium, stainless steel, nickel-titanium alloys, tantalum and gold.
- Any or all elements of the device and/or other devices or apparatuses described herein, can be, have, and/or be completely or partially coated with agents and/or a matrix a matrix for cell ingrowth or used with a fabric, for example a covering (not shown) that acts as a matrix for cell ingrowth. The matrix and/or fabric can be, for example, polyester (e.g., DACRON® from E. I. Du Pont de Nemours and Company, Wilmington. DE), polypropylene, PTFE, ePTFE, nylon, extruded collagen, silicone or combinations thereof.
- The device and/or elements of the device and/or other devices or apparatuses described herein and/or the fabric can be filled, coated, layered and/or otherwise made with and/or from cements, fillers, glues, and/or an agent delivery matrix known to one having ordinary skill in the art and/or a therapeutic and/or diagnostic agent. Any of these cements and/or fillers and/or glues can be osteogenic and osteoinductive growth factors.
- Examples of such cements and/or fillers includes bone chips, demineralized bone matrix (DBM), calcium sulfate, coralline hydroxyapatite, biocoral, tricalcium phosphate, calcium phosphate, polymethyl methacrylate (PMMA), biodegradable ceramics, bioactive glasses, hyaluronic acid, lactoferrin, bone motphogenic proteins (BMPs) such as recombinant human bone morphogenetic proteins (rhBMPs), other materials described herein, or combinations thereof.
- The agents within these matrices can include any agent disclosed herein or combinations thereof, including, radioactive materials; radiopaque materials; cytogenic agents; cytotoxic agents; cytostatic agents; thrombogenic agents, for example polyurethane, cellulose acetate polymer mixed with bismuth trioxide, and ethylene vinyl alcohol; lubricious, hydrophilic materials; phosphor cholene; anti-inflammatory agents, for example non-steroidal anti-inflammatories (NSAIDs) such as cyclooxygenase-1 (COX-1) inhibitors (e.g., acetylsalicylic acid, for example ASPIRIN® from Bayer AG, Leverkusen, Germany; ibuprofen, for example ADVIL® from Wyeth, Collegeville, Pa.; indomethacin; mefenamic acid), COX-2 inhibitors (e.g., VIOXX® from Merck & Co., Inc., Whitehouse Station, N.J.; CELEBREX® from Pharmacia Corp., Peapack, N.J.; (COX-1 inhibitors); immunosuppressive agents, for example Sirolimus (RAPAMUNE, from Wyeth, Collegeville, Pa.), or matrix metalloproteinase (MMP) inhibitors (e.g., tetracycline and tetracycline derivatives) that act early within the pathways of an inflammatory response. Examples of other agents are provided in Walton et al, Inhibition of Prostoglandin E2 Synthesis in Abdominal Aortic Aneurysms, Circulation, Jul. 6, 1999, 48-54; Tambiah et al, Provocation of Experimental Aortic Inflammation Mediators and Chlamydia Pneumoniae, Brit. J. Surgery 88 (7), 935-940; Franklin et al, Uptake of Tetracycline by Aortic Aneurysm Wall and Its Effect on Inflammation and Proteolysis, Brit. J. Surgery 86 (6), 771-775; Xu et al, Sp1 Increases Expression of Cyclooxygenase-2 in Hypoxic Vascular Endothelium, J. Biological Chemistry 275 (32) 24583-24589; and Pyo et al, Targeted Gene Disruption of Matrix Metalloproteinase-9 (Gelatinase B) Suppresses Development of Experimental Abdominal Aortic Aneurysms, J. Clinical Investigation 105 (11), 1641-1649 which are all incorporated by reference in their entireties.
- Methods of Use
-
FIG. 24 illustrates that a straight or curvedtransosseous delivery channel 94 can be drilled, chiseled, punched, or a combination thereof, through theiliac bone 2 and/or the sacral ala 90, for example passing through the sacroiliac joint 92. Thetransosseous delivery channel 94 have a first length or first channel through the iliac 2 and a second length or second channel through the sacrum S1. The first length of thetransosseous delivery channel 94 can be aligned with the second length of thetransosseous delivery channel 94, for example to form a substantially continuous channel. Thetransosseous delivery channel 94 can have a laterally-locatedchannel entry port 96 laterally outside of the sacral ala 90 and/oriliac bone 2. Thetransosseous delivery channel 94 can have achannel exit port 98 adjacent to the L5-S1 intervertebral disc space. For example, thechannel exit port 98 can be in the S1 endplate. Thechannel exit port 98 can be positioned so the circumference of thechannel exit port 98 tangentially coincides with or is closely adjacent to (e.g. within about 2 cm, more narrowly within about 1 cm, more narrowly within about 5 mm, yet more narrowly within about 2 mm) with the edge of the S1vertebral endplate 100. - The L5-S1 intervertebral space can be partially or completely void of soft tissue, as shown, for example from a discectomy performed before insertion of the
support device 14. For example, the discectomy can be performed by the method and device shown in U.S. Provisional Patent Application No. 61/526,630 filed 23 Aug. 2011, which is incorporated by reference herein in its entirety. -
FIG. 25 illustrates that thesupport device 14 can be inserted, as shown byarrow 102, medially through thechannel entry port 96 of thetransosseous delivery channel 94. Thedevice 14 can be removably and/or articulatably attached to adeployment tool shaft 104. -
FIG. 26 illustrates that theshaft 104 can be further translated, as shown byarrow 106, into thetransosseous delivery channel 94. Thesupport device 14 can translate toward and into the L5-S1 intervertebral disc space. The distal tip of thesupport device 14 can enter the L5-S1 nutervertebral disc. Thesupport device 14 can enter the target site of the L5-S1 intervertebral disc directly from thetransosseous delivery channel 94 without passing through any soft tissue between the L5-S1 intervertebral disc and theiliac bone 2. -
FIG. 27 illustrates that theshaft 104 can be further translated, as shown byarrow 108, medially through thetransosseous delivery channel 94. Thedevice 14 can translate, as shown byarrow 110, through the L5-S1 intervertebral disc space and the L5 and/or the S1 vertebra. Thesupport device 14 can articulate, as shown byarrow 112. One or more of thehinges 24 can rotate, articulating the segments 22. The hinges 24 can be controllably rotatably locked and unlocked, for example, by controls on the handle of the deployment tool (of which theshaft 104 is a part). - The
support device 14 can then be further translated, such as being pushed and/or vibrated (e.g., manually, ultrasonically), for example, medially and laterally, and/or superior and inferiorly, and/or anteriorly and posteriorly. The through ports and/or cavities and/or recesses 50 in thedevice 14 can be partially and/or completely filled bone morphogenic protein, therapeutic agents, other materials listed herein or combinations thereof. Thesupport device 14 can deliver a cauterizing electrical energy from the deployment tool. Thesupport device 14 andshaft 104 can have one or more longitudinal lumens that can be used to irrigate (e.g., with analgesic agents, saline, anesthetic agents, bone morphogenic proteins, visualization agents, other agents described herein, or combinations thereof) and/or aspirate (e.g., to remove irrigated material and/or debris) the target site (e.g., the L5-S1 intervertebral disc space). -
FIG. 28 illustrates that before, during or after thesupport device 14 is positioned in the L5-S1 intervertebral space, theshaft 104 can detach from thesupport device 14 and be translated laterally, as shown byarrow 114, from the L5-S1 intervertebral disc space and thetransosseous delivery channel 94. Thedeployment tool shaft 104 can remove or reposition thesupport device 14, or leave thesupport device 14 in place in the L5-S1 space. - The method shown in
FIGS. 25 through 28 can be repeated to delivermultiple support devices 14 to one or more intervertebral spaces. For example, one, two, three ormore support devices 14 can be positioned in the L4-L5 intervertebral space and/or the L5-S1 intervertebral space. The one, two, three ormore support devices 14 positioned in the L4-L5 and/or L5-S1 intervertebral spaces, can mechanically support the adjacent vertebrae and/or fix the adjacent vertebrae to each other. Bone ingrowth can occur through the throughports 50, for example fusing thesupport devices 14 to the respective surrounding vertebrae. -
FIGS. 29 through 31 illustrate that thetransosseous delivery channel 94 can have acoronal delivery angle 120 measured to thecoronal plane 122, asagittal delivery angle 124 measured to thesagittal plane 126, and atransverse delivery angle 128 measured to thetransverse plane 130. Thecoronal delivery angle 120 can be from about 0° to about 25°, for example about 12′. Thesagittal delivery angle 124 can be from about 65° to about 90°, for example about 75°. Thetransverse delivery angle 128 can be from about 0° to about 20°, for example about 10°. Thesupport device 14 andshaft 104 can be configured so thesupport device 14 can exit the channel exit port 98 (e.g., directly into the L5-S1 intervertebral disc) and articulate sufficiently to enter and pass through all or a significant portion (e.g., more than about 40%, yet more narrowly more than about 50%, yet more narrowly more than about 75%) of the width of the L5-S1 intervertebral space. -
FIGS. 30 and 31 show one or bothfemurs 132 for illustrative purposes. -
FIGS. 32 a through 32 d, and separatelyFIGS. 33 a through 33 c illustrate the deployment of thesupport device 14 into the L5-S1 intervertebral disc space target site, as described forFIGS. 24-27 . Thesupport device 14 can be delivered to a complete or partialdiscectomy target site 138 in the L5-S1 space. -
FIG. 33 d illustrates the shall 104 can be rotated, as shown byarrow 134, about the longitudinal axis of the shaft before during or after thesupport device 14 is positioned in the L5-S1 intervertebral disc space target site. Thesupport device 14 can rotate, as shown byarrow 136, in the L5-S1 intervertebral disc space, for example to control and position thesupport device 14 to an angular orientation in thetransverse plane 130. - Any elements described herein as singular can be pluralized (i.e., anything, described as “one” can be more than one). Any species element of a genus element can have the characteristics or elements of any other species element of that genus. The above-described configurations, elements or complete assemblies and methods and their elements for carrying out the invention, and variations of aspects of the invention can be combined and modified with each other in any combination.
Claims (10)
1. A method for inserting an implant to a target site between a first vertebra and a second vertebra comprising:
creating a first channel through the ilium;
creating a second channel through the sacrum, wherein the first channel is aligned with the second channel;
inserting a first rigid section of the implant through the first channel and the second channel into the target site,
rotating a second rigid section of the implant with respect to the first rigid section, wherein the first rigid section is hingedly attached to the second rigid section; and
inserting the second rigid section of the implant into the target site.
2. The method of claim 1 , wherein the second channel passes through a vertebral endplate.
3. A biological implant device for providing orthopedic support comprising:
a first rigid section with a first top plate and a first bottom plate, wherein the first rigid section is at a first terminal longitudinal and of the device; and
a second rigid section with a second top plate and a second bottom plate;
wherein the first rigid section is rotatably attached to the second rigid section, and wherein the top and bottom plates are configured to interface with hard tissue.
4. A method for inserting a support device to a target site in a spine adjacent a first vertebra comprising:
creating a channel through a non-vertebral bone and a vertebra; and
inserting the support device through the channel and into the target site.
5. The method of claim 4 , wherein creating a channel through the vertebra comprises creating a channel through a vertebral end plate.
6. The method of claim 5 , wherein inserting the support device through the channel and into the target site comprises:
inserting a first rigid section of the device through the channel and into the target site,
inserting a second rigid section of the device through the channel,
rotating the second rigid section of the implant with respect to the first rigid section, wherein the first rigid section is hingedly attached to the second rigid section; and
inserting the second rigid section of the implant into the target site.
7. The method of claim 5 , wherein creating the channel comprises drilling, with a flexible drill.
8. The method of claim 5 , wherein the non-vertebral bone comprises the pelvis.
9. The method of claim 5 , wherein the non-vertebral bone comprises the ilium.
10. The method of claim 5 , wherein the non-vertebral bone comprises the sacrum.
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Also Published As
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US20160022429A1 (en) | 2016-01-28 |
WO2012027490A3 (en) | 2014-03-27 |
WO2012027490A2 (en) | 2012-03-01 |
EP2608747A2 (en) | 2013-07-03 |
US20180368986A1 (en) | 2018-12-27 |
US10070968B2 (en) | 2018-09-11 |
US20210251772A1 (en) | 2021-08-19 |
EP2608747A4 (en) | 2015-02-11 |
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