US20120116514A1 - Semi-biological intervertebral disc replacement system - Google Patents

Semi-biological intervertebral disc replacement system Download PDF

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US20120116514A1
US20120116514A1 US13/226,026 US201113226026A US2012116514A1 US 20120116514 A1 US20120116514 A1 US 20120116514A1 US 201113226026 A US201113226026 A US 201113226026A US 2012116514 A1 US2012116514 A1 US 2012116514A1
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method
tissue
promoting material
disc
tissue promoting
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US13/226,026
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Stephen D. Kuslich
Patricia K. Kuslich
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Spineology Inc
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Spineology Inc
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Priority to US10/702,096 priority patent/US20050055094A1/en
Priority to US12/247,760 priority patent/US8012211B2/en
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Priority to US13/226,026 priority patent/US20120116514A1/en
Assigned to SPINEOLOGY, INC. reassignment SPINEOLOGY, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KUSLICH, STEPHER D.
Publication of US20120116514A1 publication Critical patent/US20120116514A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442Intervertebral or spinal discs, e.g. resilient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/46Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4603Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2/4611Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • A61F2002/2817Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • A61F2002/2835Bone graft implants for filling a bony defect or an endoprosthesis cavity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006Properties of materials and coating materials
    • A61F2002/30075Properties of materials and coating materials swellable, e.g. when wetted
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/4495Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/46Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4603Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2002/4625Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use
    • A61F2002/4627Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0061Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable

Abstract

Disclosed is a system and method for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity, resulting in a partial biological disc replacement. Multiplicities of fibronous pieces of fibro-cartilaginous tissue promoting material are inserted into the DDD cavity inducing tissue growth. The fibro-cartilaginous tissue

Description

    PRIORITY
  • This application is a divisional of U.S. application Ser. No. 12/247,760, filed Oct. 8, 2008, now U.S. Pat. No. 8,012,211, which is a divisional of U.S. application Ser. No. 10/702,096, filed Nov. 5, 2003, abandoned, which claims the benefit of U.S. Provisional Application No. 60/423,900 filed Nov. 5, 2002, the disclosures of each of which are hereby fully incorporated herein by reference in their entirety.
  • FIELD
  • The present invention relates generally to the field of systems adapted to replacing or assisting bone of a natural vertebral column of a living body. More specifically, the present invention relates to a system and method that surgeons can use to construct a semi-biological nuclear replacement that will replace the diseased nucleus and ultimately function in a manner similar to a natural disc nucleus.
  • BACKGROUND
  • Low back pain is a condition affecting millions of humans. This syndrome causes great personal, economic and social hardship. Resultant consequences to family members, co-workers and the community are significant.
  • Scientific evidence indicates that the symptoms of low back pain are most commonly caused by degenerative pathology in the spinal motion segment. The spinal motion segment consists of a unit of spinal anatomy bounded by two vertebral bodies that includes the two vertebral bodies and the interposed intervertebral disc, as well as the attached ligaments, muscles and the facet joints. Degenerative pathology in the spinal motion segment is primarily related to intervertebral disc degeneration.
  • The fundamental causes of intervertebral disc degeneration are incompletely understood. However, scientific studies substantiate the following general conclusions about the sequential development of degenerative spinal pathology: The nucleus (the central cushion of the disc) loses nutritional support, dehydrates, and fragments. The loss in nutritional support causes nuclear tissue necrosis, the cells die. As the nuclear tissue dies, the pH in the nuclear region decreases and highly irritative chemicals form in the disc. Consequently, as the nucleus can no longer support compression loads, the annulus (the fibrous rim of the disc, surrounding the nucleus) is subjected to loading forces, in the form of compression and shear, that the annulus is poorly designed to handle.
  • Nociceptive nerve elements, i.e., pain generating, nerve ending afferents in the outer annulus, are stimulated by a combination of chemical and mechanical forces (leakage of irritative chemicals and compression and shear force on the annulus and spinal motion segment). These pain-detecting nerve elements propagate signals in the central and autonomic nervous system pathways, leading to the activation of central pain-modulating and pain-appreciating centers in the spinal cord and brain. The conscious portions of the brain interpret the resultant excitement of certain nerve centers in the spinal cord and brain as somatic and visceral pain.
  • The inventor and his team performed experimental studies directed to the tissue origin of spinal pain. The results of the inventor's observations, recorded during operations on humans undergoing spinal surgery under local anesthesia, conclusively demonstrated that the symptoms of mechanical low back pain originate when the outer portion of the degenerative intervertebral disc (and to a lesser extent, the capsule of the facet joint) is/are stimulated by mechanical forces. Kuslich, Stephen D., Ulstrom, Cynthia L.; “The Origin of Low Back Pain and Sciatica: A Microsurgical Investigation”; Orthop Clin North Am 1991 April; 22(2): 181-7.
  • For reasons that are not perfectly clear many, if not most, humans develop the aforementioned pathologic changes in the disc nucleus as they approach middle age. Breakdown products of the disc and facet joints stimulate sensitive nerve endings in and around the disc and facet capsule, producing low back pain, and sometimes, sciatica. This pathologic phenomenon is commonly referred to as Degenerative Disc Disease (“DDD”). Degenerative Disc Disease is the primary cause of low back pain. The DDD tissue consists of the dead and/or dying fibrocartilogenous remains of the disc nucleus and inner portions of the annulus. Various toxic chemicals—such as Substance P—have been detected in DDD discs. Other investigators have described low pH (acidity) of fluids in DDD tissue. These chemicals and fluids leak out through fissures and tears in the annulus and irritate and stimulate the nociceptive nerve endings causing back pain.
  • Although, effective means to prevent DDD do not exist, some relatively effective treatments for DDD do exist. A number of medical and surgical strategies are known to ameliorate symptoms. These include: pain medications that block or modulate pain afferents, or suppress central pain-recognition centers, exercises that promote tissue nutrition, flexibility and muscle strength (exercises also stimulate the release of endorphin, an endogenous morphine-like chemical), braces that restrict motion and reduce forces on tender spinal tissues, anti-inflammatory oral and injectable medications, and surgical procedures designed to remove tissues pressing on nerves, stabilize spinal motion segments and/or replace pathological tissues.
  • Most surgical procedures designed to relieve low back pain and sciatica involves removal of a portion of the intervertebral disc. Unfortunately, removing disc tissue leaves a void in the intervertebral space. The patient's pain following partial or complete disc removal may be more severe than the pain preceding the operation. Therefore, surgeons often perform additional operations that are intended to restabilize the spinal motion segment.
  • Strategies for restabilization are many and include: heating the annular region in an effort to destroy nerve endings and “strengthen” or “heal” the annulus, “fusing” the motion segment by applying bone graft on the sides of the motion segment, or within the disc space, applying rigid or semi-rigid support members on the sides of the motion segment or within the disc space, removing and replacing the entire disc with a non-flexible, articulating artificial device and removing and replacing the nucleus.
  • A number of artificial disc replacements have been developed. The currently available devices fall into two general categories: total disc replacements and nuclear replacements. The first category consists of total disc replacements that are made of rigid, inert substances such as metal and plastic. Examples of such devices are the Fernstrom “ball-bearing” and the LINK® and PRODISC® devices.
  • These types of artificial discs have five main disadvantages. First, is that the devices are relatively large and non-compressible, so they require relatively large surgical exposures, thereby increasing the chance of morbidity, including infection and hemorrhage. Second, because the devices are constructed from rigid inert metal and plastic materials, they can cause serious damage if they were to displace into positions normally occupied by local nervous or vascular tissues. Third, the device implantation requires the removal of a large portion of the annulus. Such removal greatly reduces the inherent stability of the motion segment, at least early on, before healing occurs around the implant. Fourth, these inert, rigid-component disc replacements do not reproduce natural disc mechanics. Finally, unless these devices become and remain firmly attached to the vertebral endplates, relative motion between the implant and the vertebral bone will cause erosion of the vertebral endplates, possibly leading to subsidence, instability and/or neurological or vascular damage.
  • A second class of disc replacement is the nuclear replacement, a form of partial disc replacement. Examples include: the Ray implant (U.S. Pat. No. 4,772,287), the Bao implant (U.S. Pat. No. 5,192,326), and the Sulzer spiral implant (U.S. Pat. No. 5,919,235).
  • These devices are also inert, somewhat flexible, non-biological disc replacements. They involve removal of the nucleus and replacement of the nucleus with a non-biological plastic material that may be flexible and malleable. When these devices are placed in the excavated DDD cavity, they rub against living end-plate cartilage and bone. This rubbing may cause healthy living tissue to erode. This erosion may weaken the living cartilage and bone, resulting in subsidence of the device, fragmentation of the device and perhaps, further vertebral instability. Complete displacement and dislocation of the Ray implant has been reported.
  • This second category of disc replacements is intended to more closely mimic natural disc mechanics. To accomplish this, some nuclear replacements utilize the water-containing properties of hydrogel. One embodiment of the Ray implant as described in U. S. Pat. Nos. 4,772,287 and 4,904,260 consists of a block of hydrogel in combination with inert jacket such as a plastic fabric casing. The Bao implant as described in U.S. Pat. No. 5,192,326 consists of hydrogel beads enclosed by a fabric shell.
  • Devices using large blocks of hydrogel and other inert substances have three main problems. First, there is a 10 to 50 percent extrusion rate of the prosthetic disc beyond the DDD cavity during the post-operative period. Second, because physiologic loads and movements continue after operation, this prosthetic device can erode into the intervertebral bone, increasing instability. Third, inserting the device requires a moderate sized surgical exposure.
  • Kotani, et al. at Hokkaido University in Japan are developing an artificial disc made of a preformed fabric matrix (Spine 2001; 26:1562-1569). The fabric matrix is intended to mimic the mechanics of a natural disc. However, this technology also has shortcomings. First, the device's insertion requires a large exposure with a loss of vertebral stabilizers, i.e., the relatively large area of annulus removed during implantation. Second, the device requires that a complex weaving procedure be undertaken during manufacture. Third, many different sizes will be required for different patients and procedures. Fourth, the device must be pre-sized to fit the cavity in the disc. Fifth, since its components contain no water-imbibing component, it cannot re-hydrate itself when local ambient pressures decrease. Thus, it cannot remain hydrated in response to diurnal rhythms and function as a natural disc would function.
  • Devices attempting to mimic the mechanics of a natural disc also include such devices as taught in U.S. Pat. No. 6,240,926 to Chin Gan et al. This patent uses a hybrid of cultured intervertebral disc cells and a biodegradable substrate as a nuclear replacement. The device attempts to induce intervertebral disc reformation by regenerating natural disc tissue via the introduction of cultured intervertebral disc cells. Technology such as this is in an early stage of development. Compared to the wide experience with biocompatible materials such as plastics and metals, purely biological replacements may or may not prove to be practical.
  • While numerous techniques and devices have been developed to stabilize a spinal motion segment in an effort to ameliorate the consequences of DDD, there is a continuing need for improvements in this field.
  • SUMMARY
  • The present invention is a system for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity, resulting in a partial biological disc replacement. Multiplicities of fibronous pieces of fibro-cartilaginous tissue promoting material are inserted into the DDD cavity inducing tissue growth. The fibro-cartilaginous tissue promoting material may be combined with hydrogel or other suitable water-imbibing material.
  • The present invention improves upon current techniques by creating a biological disc replacement that induces living, natural fibrous tissue growth into the DDD cavity. It is believed that living, natural fibrous tissue is preferable to dead and/or dying DDD tissue. First, living natural fibrous tissue does not exhibit acidic properties nor leak chemicals that may cause nerve inflammation and back pain. Second, living natural fibrous tissue offers more support and stability than decaying tissue.
  • Living natural fibrous tissue is also preferable to inert disc replacements. Living natural fibrous tissue will not erode adjacent cartilage or bone. Furthermore, there is less danger to surrounding tissues or nerves should the replaced material extrude from its intended position. Finally, living natural fibrous or fibro-cartilaginous tissue is more likely to mimic the biomechanical and morphologic characteristics of a natural disc.
  • The present invention replaces the dead and/or dying fibro-cartilage of a DDD disc by stimulating living natural fibrous tissue growth with a multiplicity of fibronous pieces, this living natural fibrous tissue fuses with the living tissue of the DDD cavity, forming a partial biological disc replacing the removed DDD tissue.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a perspective view of bands of fibro-cartilaginous tissue promoting material placed in a disc cavity.
  • FIG. 2 is a perspective view of fibro-cartilaginous tissue promoting material placed in a disc cavity.
  • FIG. 3 is a perspective view of an OPTIMESH™ filled with fibro-cartilaginous tissue promoting material in a disc cavity.
  • FIG. 4 is a cross-sectional view of an OPTIMESH™ filled with fibro-cartilaginous tissue promoting material in a disc cavity.
  • FIG. 5 is a perspective view of a mixture of cotton and hydrogel fibers.
  • FIG. 6 is a cross-sectional depiction of the expansion of the hydrogel as the hydrogel absorbs fluid.
  • FIG. 7 is a perspective of the expansion of the mixture of fibro-cartilaginous tissue promoting material and hydrogel as the hydrogel absorbs fluid.
  • FIG. 8 depicts aliquots of the fibro-cartilaginous tissue promoting material and hydrogel being inserted by a piston through a small diameter tube into the disc cavity.
  • FIG. 9 is a cross-sectional view of the fibro-cartilaginous tissue promoting material and hydrogel being inserted by a piston through a small diameter tube into the disc cavity.
  • FIG. 10 is a cross-sectional view of the bundles of fibro-cartilaginous tissue promoting material and hydrogel expanding as the hydrogel absorbs water.
  • DETAILED DESCRIPTION
  • The present invention mimics the biomechanics of a natural disc nucleus by inducing natural fibrous tissue growth. FIG. 1 depicts the device 10 of the present invention embodied in a preparation of multilayered bands of suitable fibrous tissue promoting material piled in a circular configuration 12 formed to fit securely in the DDD cavity 14. The suitable fibrous tissue promoting material may include, but is not limited to, autograft, allograft or xenograft of fascia lata and/or throraco-lumbar fascia; natural and/or manmade polymeric fiber; fibrous tissue inducers such as: talc, pharmaceuticals and/or minerals; fibrous tissue morphogenic protein produced by recombinant DNA technology and/or notochord cells from stem cell technology and/or any combination thereof.
  • FIG. 2 depicts another embodiment of the device 10 as a tangled knot of suitable fibrous tissue promoting fibers 16. In yet another embodiment, the device is multiple fabric bands made of suitable fibrous tissue promoting material. In another embodiment, the device is any combination of fibers, string, multilayered bands and/or fabric bands made of suitable fibrous tissue promoting material.
  • Finally, as depicted in FIGS. 4 and 5, another embodiment of the device is a preparation of suitable fibrous tissue promoting material in combination with hydrogel chunks and/or fibers 20. This embodiment has many advantages. The hydrogel provides water-imbibing qualities similar to a natural disc. The hydrogel thus provides a source of hydration for the device. As the hydrogel absorbs water, the hydrogel and thus the device expands. FIGS. 6 and 7 show the fluid expansion as arrows 22 a and 22 b. The suitable fibrous tissue promoting material induces living, natural fibrous tissue growth. The living, natural fibrous tissue gives stability and cushion to the DDD cavity. The combination of stability, cushioning and hydration allows the device of the present invention to closely mimic the characteristics of a natural disc.
  • FIG. 8 depicts an important feature differentiating the present invention from all of its predecessors; the device is preferably constructed within the nuclear space 24, in a piecemeal fashion, by pushing small aliquots 26 of the filaments that make up the ultimate device, through a small diameter hollow injection tube 28. This feature allows the nuclear replacement device 10 to be introduced through a very small portal, with very little damage or removal of the stabilizing annulus.
  • FIG. 9 depicts an embodiment of the invention where the tissue promoting material 32 is at least one strand with a cross-sectional diameter smaller than the diameter of the injection tube 28. The invention is really a system, therefore, that allows the surgeon to construct a nuclear replacement using minimally invasive techniques. The system consists of a hollow injection tube 28, a piston 30, the filaments 26 (cotton or other fibrous tissue stimulating agents with or without hydrogel) and, in at least one embodiment, a fabric or other porous shell 18 that surrounds and contains the filamentous elements.
  • The method of the present invention involves boring a small entrance hole into the DDD cavity 14. This step can be accomplished using any of several approaches: posterior laminotomy, transforaminal, or any of the anterior or anterior-lateral approaches, including endoscopic approaches. The surgeon then reams the cavity 14 to remove the DDD nucleus and perhaps some of the endplate cartilage and portions of the inner annulus. The cavity 14 is thereby prepared for the optiplasty device insertion.
  • The cavity 14 may be prepared by coating its surface with talc, a pharmaceutical or other suitable fibrous tissue promoting material. The multiplicity of fibronous pieces of fibro-cartilaginous tissue promoting material are then inserted using a piston 30 through a small diameter tube 28 and may or may not be secured within an Optimesh™, of U.S. Pat. No. 5,571,189 to the applicant, or any other suitable porous bag.

Claims (29)

1. A method of constructing a semi-biologic nuclear replacement for a degenerated disc of a spine of a mammalian body comprising:
boring a small entrance hole having a first cross-sectional diameter into the degenerated disc;
creating a cavity having a maximum second cross-sectional diameter that is larger than the first diameter by reaming the degenerated disc and at least partially removing a degenerated disc nucleus via the small entrance hole;
inserting a porous container into the cavity; and
inserting a plurality of pieces of tissue promoting material into the container to create the semi-biologic nuclear replacement for the degenerated disc by stimulating the tissue forming response in the mammalian body to the tissue promoting material.
2. The method of claim 1 wherein the tissue promoting material is selected from a group consisting of fibrous tissue promoting material, cartilaginous promoting material and any combination thereof.
3. The method of claim 1 wherein endplate cartilage is partially removed.
4. The method of claim 1 wherein endplate cartilage is retained.
5. The method of claim 22 wherein portions of an outer annulus are removed.
6. The method of claim 1 wherein portions of an outer annulus are retained.
7. The method of claim 1 wherein the tissue promoting material is selected from a group comprising: autograft, allograft, or xenograft of fascia, manmade polymeric fiber, talc, tissue promoting pharmaceuticals, tissue promoting minerals, tissue morphogenic protein, notochord cells and any combination thereof.
8. The method of claim 1 wherein the disc cavity surface is coated with a tissue promoting material.
9. The method of claim 1 wherein the tissue promoting material is combined with hydrogel.
10. A method of constructing a semi-biologic nuclear replacement for a degenerated disc of a spine of a mammalian body comprising:
boring a small entrance hole into the degenerated disc;
creating a cavity by reaming the degenerated disc and at least partially removing a degenerated disc nucleus via the small entrance hole; and
inserting at least one strand of pliable tissue promoting material into the cavity such that a length of the at least one strand is folded within the cavity to create the semi-biologic nuclear replacement for the degenerated disc by stimulating the tissue forming response in the mammalian body to the tissue promoting material.
11. The method of claim 10 wherein the tissue promoting material is selected from a group consisting of fibrous tissue promoting material, cartilaginous promoting material and any combination thereof.
12. The method of claim 10 wherein endplate cartilage is partially removed.
13. The method of claim 10 wherein the endplate cartilage is retained.
14. The method of claim 10 wherein portions of an outer annulus are removed.
15. The method of claim 10 wherein an outer annulus is retained.
16. The method of claim 10 wherein the tissue promoting material is selected from a group consisting of: autograft, allograft, or xenograft of fascia lata, autograft, manmade polymeric fiber, talc, tissue promoting pharmaceuticals, tissue promoting minerals, tissue morphogenic protein, notochord cells, and any combination thereof.
17. The method of claim 10 wherein the disc cavity surface is coated with a tissue promoting material.
18. The method of claim 10 wherein the tissue promoting material is combined with hydrogel.
19. The method of claim 10 further comprising: inserting a porous container into the disc cavity; said porous container adapted for tissue promoting material insertion therein.
20. A method of constructing a semi-biologic nuclear replacement for a degenerated disc of a spine of a mammalian body comprising:
boring a small entrance hole into the degenerated disc;
creating a cavity by reaming the degenerated disc and at least partially removing a degenerated disc nucleus via the small entrance hole; and
inserting a plurality of pieces of tissue promoting material combined with a plurality of pieces of hydrogel into the cavity to create the semi-biologic nuclear replacement for the degenerated disc by stimulating the tissue forming response in the mammalian body to the tissue promoting material and hydrogel.
21. The nuclear replacement of claim 20 wherein the tissue promoting material is selected from a group consisting of fibrous tissue promoting material, cartilaginous promoting material and any combination thereof.
22. The method of claim 20 wherein endplate cartilage is partially removed.
23. The method of claim 20 wherein the endplate cartilage is retained.
24. The method of claim 20 wherein portions of an outer annulus are removed.
25. The method of claim 20 wherein an outer annulus is retained.
26. The method of claim 20 wherein the tissue promoting material is selected from a group consisting of: autograft, allograft, or xenograft of fascia lata, autograft, manmade polymeric fiber, talc, tissue promoting pharmaceuticals, tissue promoting minerals, tissue morphogenic protein, notochord cells, and any combination thereof.
27. The method of claim 20 wherein the disc cavity surface is coated with a tissue promoting material.
28. The method of claim 20 further comprising:
inserting a porous container into the disc cavity;
said porous container adapted for tissue promoting material insertion therein.
29. A method of constructing a semi-biologic nuclear replacement for a degenerated disc of a spine of a mammalian body comprising:
providing a porous container adapted for placement in the disc;
providing a plurality if pieces of strands of tissue promoting material; and
providing instructions for constructing a semi-biologic nuclear replacement of the degenerated disc, including:
boring a small entrance hole having a first cross-sectional diameter into the degenerated disc;
creating a cavity having a maximum second cross-sectional diameter that is larger than the first diameter by reaming the degenerated disc and at least partially removing a degenerated disc nucleus via the small entrance hole;
inserting the container into the cavity; and
inserting a plurality of pieces of strands tissue promoting material into the container to create the semi-biologic nuclear replacement for the degenerated disc by stimulating the tissue forming response in the mammalian body to the tissue promoting material.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9433404B2 (en) 2012-10-31 2016-09-06 Suture Concepts Inc. Method and apparatus for closing fissures in the annulus fibrosus
US9949734B2 (en) 2012-10-31 2018-04-24 Suture Concepts Inc. Method and apparatus for closing a fissure in the annulus of an intervertebral disc, and/or for effecting other anatomical repairs and/or fixations

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030008396A1 (en) * 1999-03-17 2003-01-09 Ku David N. Poly(vinyl alcohol) hydrogel
CA2594492A1 (en) 1999-03-07 2000-09-14 Active Implants Corporation Method and apparatus for computerized surgery
US7717961B2 (en) 1999-08-18 2010-05-18 Intrinsic Therapeutics, Inc. Apparatus delivery in an intervertebral disc
EP1328221B1 (en) 1999-08-18 2009-03-25 Intrinsic Therapeutics, Inc. Devices for nucleus pulposus augmentation and retention
WO2004100841A1 (en) 1999-08-18 2004-11-25 Intrinsic Therapeutics, Inc. Devices and method for augmenting a vertebral disc nucleus
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
WO2004041075A2 (en) * 2002-11-05 2004-05-21 Spineology, Inc. A semi-biological intervertebral disc replacement system
CN100394989C (en) 2002-11-15 2008-06-18 华沙整形外科股份有限公司 Use of composition containing particulate collagen-based materials in preparing medicament, and synovial joint containing the composition
US20040186471A1 (en) * 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
EP1786485A4 (en) * 2004-02-06 2012-05-30 Georgia Tech Res Inst Surface directed cellular attachment
CA2558661C (en) * 2004-02-06 2012-09-04 Georgia Tech Research Corporation Load bearing biocompatible device
US7485145B2 (en) * 2004-02-23 2009-02-03 Alphatec Spine, Incorporated Artificial intervertebral disc assembly
JP2007530120A (en) * 2004-03-26 2007-11-01 ヌヴァシヴ インコーポレイテッド Spinal disc nucleus pulposus replacement porous implant
DE602005027672D1 (en) * 2004-03-26 2011-06-09 Nuvasive Inc Disc prosthesis
US20050278025A1 (en) * 2004-06-10 2005-12-15 Salumedica Llc Meniscus prosthesis
EP1623727A1 (en) 2004-07-14 2006-02-08 Bruno Sidler Fller and administration device for forming a supportive structure in a bone cavity
US7879103B2 (en) 2005-04-15 2011-02-01 Musculoskeletal Transplant Foundation Vertebral disc repair
US20070042326A1 (en) * 2005-06-01 2007-02-22 Osseous Technologies Of America Collagen antral membrane expander
JP4907908B2 (en) * 2005-06-29 2012-04-04 ルネサスエレクトロニクス株式会社 Driving circuit and display device
GB0514891D0 (en) * 2005-07-20 2005-08-24 Pearsalls Ltd Improvements in and relating to implants
US7972337B2 (en) 2005-12-28 2011-07-05 Intrinsic Therapeutics, Inc. Devices and methods for bone anchoring
US20070213717A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Biological fusion in the vertebral column
US20070213822A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Treatment of the vertebral column
US20070227547A1 (en) * 2006-02-14 2007-10-04 Sdgi Holdings, Inc. Treatment of the vertebral column
US20070213718A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Treatment of the vertebral column
US8133279B2 (en) 2006-04-27 2012-03-13 Warsaw Orthopedic, Inc. Methods for treating an annulus defect of an intervertebral disc
US20070255406A1 (en) * 2006-04-27 2007-11-01 Sdgi Holdings, Inc. Devices, apparatus, and methods for bilateral approach to disc augmentation
US20070255286A1 (en) * 2006-04-27 2007-11-01 Sdgi Holdings, Inc. Devices, apparatus, and methods for improved disc augmentation
US20070276496A1 (en) * 2006-05-23 2007-11-29 Sdgi Holdings, Inc. Surgical spacer with shape control
US10143560B2 (en) 2006-06-08 2018-12-04 Francis Pflum Sac for use in spinal surgery
US8226722B2 (en) 2006-06-08 2012-07-24 Francis Pflum Sac for use in spinal surgery
US8118779B2 (en) 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
US8399619B2 (en) 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
WO2008013763A2 (en) * 2006-07-25 2008-01-31 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
EP2063808A4 (en) * 2006-09-14 2012-06-13 Spineology Inc Absorbent fabric implant
US9237916B2 (en) 2006-12-15 2016-01-19 Gmedeleware 2 Llc Devices and methods for vertebrostenting
IL181211D0 (en) * 2007-02-07 2007-07-04 Nmb Medical Applic Ltd Device and methods for strengthening long bones
CA2693069C (en) * 2007-07-03 2013-12-10 Spine Tek, Inc. Interspinous mesh
US8282681B2 (en) * 2007-08-13 2012-10-09 Nuvasive, Inc. Bioresorbable spinal implant and related methods
US20110196492A1 (en) * 2007-09-07 2011-08-11 Intrinsic Therapeutics, Inc. Bone anchoring systems
US8323341B2 (en) 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
US20090222096A1 (en) * 2008-02-28 2009-09-03 Warsaw Orthopedic, Inc. Multi-compartment expandable devices and methods for intervertebral disc expansion and augmentation
US8377135B1 (en) 2008-03-31 2013-02-19 Nuvasive, Inc. Textile-based surgical implant and related methods
FR2929502B1 (en) * 2008-04-04 2011-04-08 Clariance Implant nucleic.
US8114156B2 (en) * 2008-05-30 2012-02-14 Edwin Burton Hatch Flexibly compliant ceramic prosthetic meniscus for the replacement of damaged cartilage in orthopedic surgical repair or reconstruction of hip, knee, ankle, shoulder, elbow, wrist and other anatomical joints
WO2009155319A1 (en) 2008-06-17 2009-12-23 Soteira, Inc. Devices and methods for fracture reduction
US9220598B2 (en) * 2009-02-12 2015-12-29 Warsaw Orthopedic, Inc. Delivery systems, tools, and methods of use
US9277999B2 (en) * 2009-02-27 2016-03-08 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds
WO2010111246A1 (en) 2009-03-23 2010-09-30 Soteira, Inc. Devices and methods for vertebrostenting
JP2011078745A (en) * 2009-09-09 2011-04-21 Kinki Univ Bone prosthetic material
US9320601B2 (en) 2011-10-20 2016-04-26 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
CA2837303C (en) 2011-05-26 2019-08-20 Cartiva, Inc. Tapered joint implant and related tools
WO2013075091A1 (en) * 2011-11-17 2013-05-23 Allosource Multi-piece machine graft systems and methods
US20130282121A1 (en) * 2012-03-22 2013-10-24 Ann Prewett Spinal facet augmentation implant and method
EP2877129B1 (en) 2012-07-25 2017-10-11 Spineology, Inc. Mesh spacer hybrid
ITPI20120106A1 (en) * 2012-10-19 2014-04-20 Giancarlo Guizzardi Device and system for vertebral arthrodesis
US9907654B2 (en) * 2012-12-11 2018-03-06 Dr. H.C. Robert Mathys Stiftung Bone substitute and method for producing the same
US20140277467A1 (en) 2013-03-14 2014-09-18 Spinal Stabilization Technologies, Llc Prosthetic Spinal Disk Nucleus
CN106999286B (en) 2014-11-04 2019-08-16 脊柱稳定技术有限责任公司 The nucleus prosthesis that can be percutaneously implantable
AU2016243659A1 (en) 2015-03-31 2017-10-19 Cartiva, Inc. Hydrogel implants with porous materials and methods
WO2016168363A1 (en) 2015-04-14 2016-10-20 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods

Citations (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5549679A (en) * 1994-05-20 1996-08-27 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US5562736A (en) * 1994-10-17 1996-10-08 Raymedica, Inc. Method for surgical implantation of a prosthetic spinal disc nucleus
US5755797A (en) * 1993-04-21 1998-05-26 Sulzer Medizinaltechnik Ag Intervertebral prosthesis and a process for implanting such a prosthesis
US6110210A (en) * 1999-04-08 2000-08-29 Raymedica, Inc. Prosthetic spinal disc nucleus having selectively coupled bodies
US6132465A (en) * 1998-06-04 2000-10-17 Raymedica, Inc. Tapered prosthetic spinal disc nucleus
US6224630B1 (en) * 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
US6245107B1 (en) * 1999-05-28 2001-06-12 Bret A. Ferree Methods and apparatus for treating disc herniation
US6332894B1 (en) * 2000-03-07 2001-12-25 Zimmer, Inc. Polymer filled spinal fusion cage
US6371990B1 (en) * 1999-10-08 2002-04-16 Bret A. Ferree Annulus fibrosis augmentation methods and apparatus
US20020045942A1 (en) * 2000-10-16 2002-04-18 Ham Michael J. Procedure for repairing damaged discs
US20020068974A1 (en) * 2000-07-21 2002-06-06 Kuslich Stephen D. Expandable porous mesh bag device and methods of use for reduction, filling, fixation and supporting of bone
US6402784B1 (en) * 1997-07-10 2002-06-11 Aberdeen Orthopaedic Developments Limited Intervertebral disc nucleus prosthesis
US20020077701A1 (en) * 2000-12-15 2002-06-20 Kuslich Stephen D. Annulus-reinforcing band
US6419704B1 (en) * 1999-10-08 2002-07-16 Bret Ferree Artificial intervertebral disc replacement methods and apparatus
US6425919B1 (en) * 1999-08-18 2002-07-30 Intrinsic Orthopedics, Inc. Devices and methods of vertebral disc augmentation
US20020147497A1 (en) * 2001-04-06 2002-10-10 Integrated Vascular Systems, Inc. Methods for treating spinal discs
US20020173851A1 (en) * 1999-12-06 2002-11-21 Mckay William F. Intervertebral disc treatment devices and methods
US6508839B1 (en) * 1999-08-18 2003-01-21 Intrinsic Orthopedics, Inc. Devices and methods of vertebral disc augmentation
US6602261B2 (en) * 1999-10-04 2003-08-05 Microvention, Inc. Filamentous embolic device with expansile elements
US6602291B1 (en) * 1999-04-05 2003-08-05 Raymedica, Inc. Prosthetic spinal disc nucleus having a shape change characteristic
US6620196B1 (en) * 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US20030195630A1 (en) * 2002-04-10 2003-10-16 Ferree Bret A. Disc augmentation using materials that expand in situ
US20030220695A1 (en) * 2000-09-26 2003-11-27 Sevrain Lionel C. Inter-vertebral disc prosthesis for lumbar rachis through posterior surgery thereof
US20040054413A1 (en) * 2002-09-16 2004-03-18 Howmedica Osteonics Corp. Radiovisible hydrogel intervertebral disc nucleus
US20040059417A1 (en) * 2002-09-25 2004-03-25 Medicinelodge, Inc. Apparatus and method for the in-situ formation of a structural prosthesis
US6746485B1 (en) * 1999-02-18 2004-06-08 St. Francis Medical Technologies, Inc. Hair used as a biologic disk, replacement, and/or structure and method
US20040109823A1 (en) * 2000-11-16 2004-06-10 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
US20040215343A1 (en) * 2000-02-28 2004-10-28 Stephen Hochschuler Method and apparatus for treating a vertebral body
US20050027358A1 (en) * 2003-07-29 2005-02-03 Loubert Suddaby Inflatable nuclear prosthesis
US20050055094A1 (en) * 2002-11-05 2005-03-10 Kuslich Stephen D. Semi-biological intervertebral disc replacement system
US6869445B1 (en) * 2000-05-04 2005-03-22 Phillips Plastics Corp. Packable ceramic beads for bone repair
US6899719B2 (en) * 1994-01-26 2005-05-31 Kyphon Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
US6969404B2 (en) * 1999-10-08 2005-11-29 Ferree Bret A Annulus fibrosis augmentation methods and apparatus
US7001431B2 (en) * 1994-05-06 2006-02-21 Disc Dynamics, Inc. Intervertebral disc prosthesis
US20060253202A1 (en) * 2005-05-05 2006-11-09 Lipov Eugene G Vertebral disc implant in fiber form
US20060265077A1 (en) * 2005-02-23 2006-11-23 Zwirkoski Paul A Spinal repair
US20070055272A1 (en) * 2005-08-16 2007-03-08 Laurent Schaller Spinal Tissue Distraction Devices
US20070093899A1 (en) * 2005-09-28 2007-04-26 Christof Dutoit Apparatus and methods for treating bone
US7223227B2 (en) * 2002-05-13 2007-05-29 Pflueger D Russell Spinal disc therapy system
US20070150059A1 (en) * 2005-12-22 2007-06-28 Depuy Spine, Inc. Methods and devices for intervertebral augmentation using injectable formulations and enclosures
US7309359B2 (en) * 2003-08-21 2007-12-18 Warsaw Orthopedic, Inc. Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs
US20080051800A1 (en) * 2004-05-03 2008-02-28 Robert Diaz Method and device for reducing susceptibility to fractures in vertebral bodies
US20080132899A1 (en) * 2004-05-17 2008-06-05 Shadduck John H Composite implant and method for treating bone abnormalities
US20080140084A1 (en) * 1994-01-26 2008-06-12 Kyphon Inc. Methods for treating a fractured and/or diseased and/or weakened bone
US20080249604A1 (en) * 2007-03-30 2008-10-09 Brian Donovan Apparatus and method for medical procedures within a spine
US7445634B2 (en) * 2000-10-27 2008-11-04 Warsaw Orthopedic, Inc. Annulus repair systems and methods
US7465318B2 (en) * 2004-04-15 2008-12-16 Soteira, Inc. Cement-directing orthopedic implants
US7507243B2 (en) * 1999-08-18 2009-03-24 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US7520888B2 (en) * 2006-02-14 2009-04-21 Warsaw Orthopedic, Inc. Treatment of the vertebral column
US7520900B2 (en) * 2000-08-30 2009-04-21 Warsaw Orthopedic, Inc. Intervertebral disc nucleus implants and methods
US20090125031A1 (en) * 2007-11-14 2009-05-14 Cook Incorporated Method and bone cement substitute kit for stabilizing a collapsed vertebra of a patient
US7534268B2 (en) * 2006-01-13 2009-05-19 Zimmer Spine, Inc. Devices and methods for disc replacement
US7553329B2 (en) * 1999-08-18 2009-06-30 Intrinsic Therapeutics, Inc. Stabilized intervertebral disc barrier
US7563282B2 (en) * 1999-08-18 2009-07-21 Intrinsic Therapeutics, Inc. Method of supporting nucleus pulposus
US7563284B2 (en) * 2002-08-15 2009-07-21 Synthes Usa, Llc Intervertebral disc implant
US7601157B2 (en) * 2001-11-01 2009-10-13 Spine Wave, Inc. Devices and methods for the restoration of a spinal disc
US7618461B2 (en) * 2000-08-30 2009-11-17 Warsaw Orthopedic, Inc. Composite intervertebral disc implants and methods for forming the same
US7618457B2 (en) * 2005-08-10 2009-11-17 Zimmer Spine, Inc. Devices and methods for disc nucleus replacement
US7641691B2 (en) * 2001-06-29 2010-01-05 The Regents Of The University Of California Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs
US7666205B2 (en) * 2001-04-19 2010-02-23 Synthes Usa, Llc Inflatable device and method for reducing fractures in bone and in treating the spine
US7682393B2 (en) * 2004-10-14 2010-03-23 Warsaw Orthopedic, Inc. Implant system, method, and instrument for augmentation or reconstruction of intervertebral disc
US7699894B2 (en) * 2005-12-22 2010-04-20 Depuy Spine, Inc. Nucleus pulposus trial device and technique
US7713303B2 (en) * 2002-09-18 2010-05-11 Warsaw Orthopedic, Inc. Collagen-based materials and methods for augmenting intervertebral discs
US7717956B2 (en) * 2001-05-25 2010-05-18 Conformis, Inc. Joint arthroplasty devices formed in situ
US7758649B2 (en) * 2006-08-04 2010-07-20 Integrity Intellect Inc. Reversibly deformable implant
US7803188B2 (en) * 2002-08-27 2010-09-28 Warsaw Orthopedic, Inc. Systems and methods for intravertebral reduction
US20100268231A1 (en) * 2000-07-21 2010-10-21 Spineology, Inc. Expandable porous mesh bag device and methods of use for reduction, filling, fixation and supporting of bone
US7879100B2 (en) * 2007-01-19 2011-02-01 Spinemedica, Llc Methods and systems for forming implants with selectively exposed mesh for fixation and related implants
US7883527B2 (en) * 1999-09-20 2011-02-08 Nuvasive, Inc. Annulotomy closure device and related methods
US7887593B2 (en) * 2002-09-18 2011-02-15 Warsaw Orthopedic, Inc. Method of implanting natural tissue within the vertebral disc nucleus space using a drawstring
US7896920B2 (en) * 2000-10-24 2011-03-01 Cryolife, Inc. In situ bioprosthetic filler and method, particularly for the in situ formation of vertebral disc bioprosthetics
US7901460B2 (en) * 2003-06-02 2011-03-08 Warsaw Orthopedic, Inc. Intervertebral disc implants and methods for manufacturing and using the same
US7959683B2 (en) * 2006-07-25 2011-06-14 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US7959676B2 (en) * 2006-02-13 2011-06-14 Lanx, Inc. Method and apparatus for intervertebral disc support and repair
US7988735B2 (en) * 2005-06-15 2011-08-02 Matthew Yurek Mechanical apparatus and method for delivering materials into the inter-vertebral body space for nucleus replacement
US7998213B2 (en) * 1999-08-18 2011-08-16 Intrinsic Therapeutics, Inc. Intervertebral disc herniation repair
USRE42837E1 (en) * 1999-09-30 2011-10-11 Replication Medical, Inc. Spinal nucleus implant
US8052728B2 (en) * 2007-07-31 2011-11-08 Zimmer Spine, Inc. Method for stabilizing a facet joint
US8092536B2 (en) * 2006-05-24 2012-01-10 Disc Dynamics, Inc. Retention structure for in situ formation of an intervertebral prosthesis
US8110003B2 (en) * 2004-09-09 2012-02-07 University Of South Florida Prostheses for spine discs having fusion capability
US8118874B2 (en) * 2004-05-21 2012-02-21 Synthes Usa, Llc Replacement or supplementation of a nucleus pulposus using a hydrogel
US8133279B2 (en) * 2006-04-27 2012-03-13 Warsaw Orthopedic, Inc. Methods for treating an annulus defect of an intervertebral disc
US8231678B2 (en) * 1999-08-18 2012-07-31 Intrinsic Therapeutics, Inc. Method of treating a herniated disc
US8282681B2 (en) * 2007-08-13 2012-10-09 Nuvasive, Inc. Bioresorbable spinal implant and related methods
US8287595B2 (en) * 2005-08-26 2012-10-16 Synthes Usa, Llc Hydrogel balloon prosthesis for nucleus pulposus

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3030951A (en) * 1959-04-10 1962-04-24 Michael P Mandarino Methods and materials for orthopedic surgery
CA992255A (en) * 1971-01-25 1976-07-06 Cutter Laboratories Prosthesis for spinal repair
US3875595A (en) * 1974-04-15 1975-04-08 Edward C Froning Intervertebral disc prosthesis and instruments for locating same
US4655777A (en) * 1983-12-19 1987-04-07 Southern Research Institute Method of producing biodegradable prosthesis and products therefrom
US5030233A (en) 1984-10-17 1991-07-09 Paul Ducheyne Porous flexible metal fiber material for surgical implantation
US4743260A (en) * 1985-06-10 1988-05-10 Burton Charles V Method for a flexible stabilization system for a vertebral column
US4735625A (en) * 1985-09-11 1988-04-05 Richards Medical Company Bone cement reinforcement and method
US4755184A (en) 1986-01-09 1988-07-05 Mark Silverberg Bone augmentation implant
CH671691A5 (en) * 1987-01-08 1989-09-29 Sulzer Ag
US4863477A (en) 1987-05-12 1989-09-05 Monson Gary L Synthetic intervertebral disc prosthesis
US5108438A (en) * 1989-03-02 1992-04-28 Regen Corporation Prosthetic intervertebral disc
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US4772287A (en) * 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
US5282856A (en) * 1987-12-22 1994-02-01 Ledergerber Walter J Implantable prosthetic device
US7534254B1 (en) 1988-06-13 2009-05-19 Warsaw Orthopedic, Inc. Threaded frusto-conical interbody spinal fusion implants
US5609635A (en) * 1988-06-28 1997-03-11 Michelson; Gary K. Lordotic interbody spinal fusion implants
AU624627B2 (en) 1988-08-18 1992-06-18 Johnson & Johnson Orthopaedics, Inc. Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness
US5147359A (en) 1988-12-21 1992-09-15 Zimmer, Inc. Spinal hook body
GB2254394B (en) 1988-12-21 1993-03-17 Squibb Bristol Myers Co Coupler assembly
CA2035348C (en) * 1990-02-08 2000-05-16 Jean-Louis Vignaud Adjustable fastening device with spinal osteosynthesis rods
US4969888A (en) * 1989-02-09 1990-11-13 Arie Scholten Surgical protocol for fixation of osteoporotic bone using inflatable device
US5015255A (en) * 1989-05-10 1991-05-14 Spine-Tech, Inc. Spinal stabilization method
DE3923996C2 (en) * 1989-07-20 1993-08-26 Lutz 7730 Villingen-Schwenningen De Biedermann
US5261913A (en) 1989-07-26 1993-11-16 J.B.S. Limited Company Device for straightening, securing, compressing and elongating the spinal column
US4936848A (en) * 1989-09-22 1990-06-26 Bagby George W Implant for vertebrae
DE59003151D1 (en) 1989-10-12 1993-11-25 Sulzer Ag Hip prosthesis with anchorage by grid areas.
US4932975A (en) * 1989-10-16 1990-06-12 Vanderbilt University Vertebral prosthesis
DE8912648U1 (en) * 1989-10-23 1990-11-22 Mecron Medizinische Produkte Gmbh, 1000 Berlin, De
US5059193A (en) 1989-11-20 1991-10-22 Spine-Tech, Inc. Expandable spinal implant and surgical method
FR2658413B1 (en) 1990-02-19 1997-01-03 Sofamor Osteosynthesis device for the correction of spinal deviations.
FR2659226B1 (en) * 1990-03-07 1992-05-29 Jbs Sa Prothese for intervertebral discs and instruments of implementation.
EP0453393B1 (en) 1990-04-20 1993-10-06 SULZER Medizinaltechnik AG Implant, particularly intervertebral prosthesis
CH685850A5 (en) * 1990-11-26 1995-10-31 Synthes Ag anchoring device
US5192326A (en) * 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US5047055A (en) 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
US5176678A (en) * 1991-03-14 1993-01-05 Tsou Paul M Orthopaedic device with angularly adjustable anchor attachments to the vertebrae
JP3007903B2 (en) * 1991-03-29 2000-02-14 京セラ株式会社 Artificial disc
FR2676354B1 (en) 1991-05-17 1997-11-07 Vignaud Jean Louis Lockable connecting device of osteosynthesis spinal anchoring elements.
US5306307A (en) * 1991-07-22 1994-04-26 Calcitek, Inc. Spinal disk implant
DE4128332A1 (en) * 1991-08-27 1993-03-04 Man Ceramics Gmbh Vertebral bone replacement
US5306309A (en) * 1992-05-04 1994-04-26 Calcitek, Inc. Spinal disk implant and implantation kit
US5275600A (en) * 1992-10-05 1994-01-04 Zimmer, Inc. Telescoping rod to rod coupler for a spinal system
JP3012095B2 (en) 1992-10-08 2000-02-21 京セラ株式会社 Processing method for elasticizing thereto and porous bioprosthetic member
US5282801A (en) * 1993-02-17 1994-02-01 Danek Medical, Inc. Top tightening clamp assembly for a spinal fixation system
US7044954B2 (en) * 1994-01-26 2006-05-16 Kyphon Inc. Method for treating a vertebral body
EP1498079A1 (en) * 1994-01-26 2005-01-19 Kyphon Inc. Improved device for use in surgical protocol relating to fixation of bone
JP3333211B2 (en) 1994-01-26 2002-10-15 ショルテン,アリー As used surgical methods for the treatment of a bone, the expandable device according to the improved
US5503164A (en) * 1994-01-28 1996-04-02 Osteogenics, Inc. Device and method for repair of craniomaxillofacial bone defects including burr holes
US6248131B1 (en) * 1994-05-06 2001-06-19 Advanced Bio Surfaces, Inc. Articulating joint repair
US5888220A (en) * 1994-05-06 1999-03-30 Advanced Bio Surfaces, Inc. Articulating joint repair
US5556429A (en) 1994-05-06 1996-09-17 Advanced Bio Surfaces, Inc. Joint resurfacing system
JPH10503667A (en) * 1994-05-24 1998-04-07 スミス アンド ネフュー ピーエルシー Intervertebral disc implant
US6022376A (en) * 1997-06-06 2000-02-08 Raymedica, Inc. Percutaneous prosthetic spinal disc nucleus and method of manufacture
US5634945A (en) * 1995-03-02 1997-06-03 Pernia; Luis R. Biological filler and use of same
ES2278091T3 (en) * 1995-11-08 2007-08-01 Zimmer Gmbh Device for introducing an implant, in particular an intervertebral prosthesis.
US5645597A (en) * 1995-12-29 1997-07-08 Krapiva; Pavel I. Disc replacement method and apparatus
US5964807A (en) * 1996-08-08 1999-10-12 Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
US5961554A (en) 1996-12-31 1999-10-05 Janson; Frank S Intervertebral spacer
AU745916B2 (en) 1997-03-07 2002-04-11 Kyphon Sarl Systems for percutaneous bone and spinal stabilization, fixation and repair
US6852095B1 (en) * 1997-07-09 2005-02-08 Charles D. Ray Interbody device and method for treatment of osteoporotic vertebral collapse
US6437018B1 (en) * 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
AU3203599A (en) * 1998-04-01 1999-10-18 Parallax Medical, Inc. Pressure applicator for hard tissue implant placement
EP1083836B1 (en) * 1998-06-01 2010-10-13 Kyphon SÀRL Expandable preformed structures for deployment in interior body regions
US6241734B1 (en) * 1998-08-14 2001-06-05 Kyphon, Inc. Systems and methods for placing materials into bone
IL128261D0 (en) * 1999-01-27 1999-11-30 Disc O Tech Medical Tech Ltd Expandable element
US6264659B1 (en) * 1999-02-22 2001-07-24 Anthony C. Ross Method of treating an intervertebral disk
US6436143B1 (en) * 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
US6183518B1 (en) * 1999-02-22 2001-02-06 Anthony C. Ross Method of replacing nucleus pulposus and repairing the intervertebral disk
US6770079B2 (en) * 1999-03-16 2004-08-03 American Osteomedix, Inc. Apparatus and method for fixation of osteoporotic bone
US6113639A (en) * 1999-03-23 2000-09-05 Raymedica, Inc. Trial implant and trial implant kit for evaluating an intradiscal space
US6428576B1 (en) * 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6783546B2 (en) * 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US7201774B2 (en) * 1999-10-08 2007-04-10 Ferree Bret A Artificial intervertebral disc replacements incorporating reinforced wall sections
US7004970B2 (en) * 1999-10-20 2006-02-28 Anulex Technologies, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US6592625B2 (en) 1999-10-20 2003-07-15 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
US20030153976A1 (en) * 1999-10-20 2003-08-14 Cauthen Joseph C. Spinal disc annulus reconstruction method and spinal disc annulus stent
US6395034B1 (en) * 1999-11-24 2002-05-28 Loubert Suddaby Intervertebral disc prosthesis
US6558390B2 (en) * 2000-02-16 2003-05-06 Axiamed, Inc. Methods and apparatus for performing therapeutic procedures in the spine
US7069087B2 (en) * 2000-02-25 2006-06-27 Oratec Interventions, Inc. Apparatus and method for accessing and performing a function within an intervertebral disc
NZ521800A (en) * 2000-04-07 2004-06-25 Kyphon Inc Insertion devices and directing the expansion of an expandable structure of the device within a bone
EP1157676B1 (en) * 2000-05-26 2005-08-03 Zimmer GmbH Spinal disc replacement for the core of an intervertebral disc
US6533817B1 (en) * 2000-06-05 2003-03-18 Raymedica, Inc. Packaged, partially hydrated prosthetic disc nucleus
US7503936B2 (en) * 2000-08-30 2009-03-17 Warsaw Orthopedic, Inc. Methods for forming and retaining intervertebral disc implants
US6733531B1 (en) * 2000-10-20 2004-05-11 Sdgi Holdings, Inc. Anchoring devices and implants for intervertebral disc augmentation
US6679914B1 (en) * 2000-11-14 2004-01-20 Shlomo Gabbay Implantable orthopedic support apparatus
US6375659B1 (en) * 2001-02-20 2002-04-23 Vita Licensing, Inc. Method for delivery of biocompatible material
US7544196B2 (en) * 2001-02-20 2009-06-09 Orthovita, Inc. System and kit for delivery of restorative materials
US6595998B2 (en) * 2001-03-08 2003-07-22 Spinewave, Inc. Tissue distraction device
WO2002089676A2 (en) * 2001-05-04 2002-11-14 Concentric Medical Hydrogel filament vaso-occlusive device
WO2004043303A2 (en) * 2002-11-12 2004-05-27 Regenex Ltd. Expandable devices and methods for tissue expansion, regenerationand fixation
US20030028251A1 (en) * 2001-07-30 2003-02-06 Mathews Hallett H. Methods and devices for interbody spinal stabilization
US7128746B2 (en) * 2002-05-16 2006-10-31 Pmt Corporation Device for treating intervertebral disc herniations
US7008431B2 (en) * 2001-10-30 2006-03-07 Depuy Spine, Inc. Configured and sized cannula
WO2003037165A2 (en) * 2001-11-01 2003-05-08 Boyd Lawrence M System and method for the pretreatment of the endplates of an intervertebral disc
GB2382028B (en) * 2001-11-19 2006-11-01 Aberdeen Orthopaedic Developme Intervertebral disc prosthesis
CZ2004681A3 (en) * 2001-12-05 2005-02-16 Mathys Medizinaltechnik Ag Intervertebral disk prosthesis or nucleus replacement prosthesis
US6953465B2 (en) * 2002-03-25 2005-10-11 Concentric Medical, Inc. Containers and methods for delivering vaso-occluding filaments and particles
DE10223332A1 (en) * 2002-05-25 2003-12-04 Efmt Entwicklungs Und Forschun medical implant
US7066960B1 (en) * 2002-06-28 2006-06-27 Dickman Curtis A Intervertebral disk replacement
US6733533B1 (en) * 2002-11-19 2004-05-11 Zimmer Technology, Inc. Artificial spinal disc
WO2004047689A1 (en) * 2002-11-21 2004-06-10 Sdgi Holdings, Inc. Systems and techniques for intravertebral spinal stablization with expandable devices
EP1594421A4 (en) * 2003-01-17 2006-02-08 Psinergi Corp Artificial nucleus pulposus and method of injecting same
US7306610B2 (en) * 2003-03-21 2007-12-11 Cana Lab Corporation Method and device for forming a hardened cement in a bone cavity
US20050010297A1 (en) * 2003-05-08 2005-01-13 Kuros Biosurgery Ag Balloon technologies for tissue repair
US20050015150A1 (en) * 2003-07-17 2005-01-20 Lee Casey K. Intervertebral disk and nucleus prosthesis
US7758647B2 (en) * 2003-07-25 2010-07-20 Impliant Ltd. Elastomeric spinal disc nucleus replacement
EP1729672A2 (en) * 2004-01-08 2006-12-13 Spine Wave, Inc. Apparatus and method for injecting fluent material at a distracted tissue site
US8029511B2 (en) * 2004-03-22 2011-10-04 Disc Dynamics, Inc. Multi-stage biomaterial injection system for spinal implants
US20050245938A1 (en) * 2004-04-28 2005-11-03 Kochan Jeffrey P Method and apparatus for minimally invasive repair of intervertebral discs and articular joints
US7749268B2 (en) * 2004-05-26 2010-07-06 Warsaw Orthopedic, Inc. Methods for treating the spine
EP1768617A4 (en) * 2004-06-29 2011-08-10 Spine Wave Inc Methods for treating defects and injuries of an intervertebral disc
US7172628B2 (en) * 2004-07-27 2007-02-06 Lonnie Jay Lamprich Spinal disc prosthesis and methods
JP2008508045A (en) * 2004-07-27 2008-03-21 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング Substituted or complement method of nucleus pulposus of the intervertebral disc
US8317864B2 (en) * 2004-10-20 2012-11-27 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US7799078B2 (en) * 2004-11-12 2010-09-21 Warsaw Orthopedic, Inc. Implantable vertebral lift
US20060149380A1 (en) * 2004-12-01 2006-07-06 Lotz Jeffrey C Systems, devices and methods for treatment of intervertebral disorders
US20060195115A1 (en) * 2005-02-23 2006-08-31 Ferree Bret A Method and apparatus for kyphoplasty
US7628800B2 (en) * 2005-06-03 2009-12-08 Warsaw Orthopedic, Inc. Formed in place corpectomy device
US7799079B2 (en) * 2006-01-18 2010-09-21 Zimmer Spine, Inc. Vertebral fusion device and method
US8518098B2 (en) * 2006-02-21 2013-08-27 Cook Medical Technologies Llc Split sheath deployment system
US20080103505A1 (en) * 2006-10-26 2008-05-01 Hendrik Raoul Andre Fransen Containment device for site-specific delivery of a therapeutic material and methods of use
EP1961433A1 (en) * 2007-02-20 2008-08-27 National University of Ireland Galway Porous substrates for implantation
WO2008137428A2 (en) * 2007-04-30 2008-11-13 Dfine, Inc. Bone treatment systems and methods
US7842095B2 (en) * 2007-09-11 2010-11-30 Howmedica Osteonics Corp. Antibiotic bone cement spacer
US7883511B2 (en) * 2007-09-12 2011-02-08 Fernyhough Jeffrey C Method and composition for use in reinforcing bone
US7799056B2 (en) * 2007-12-31 2010-09-21 Warsaw Orthopedic, Inc. Bone fusion device and methods
US7842040B2 (en) * 2008-01-18 2010-11-30 Illuminoss Medical, Inc. Internal bone fixation system with integrated mixer
US9066816B2 (en) * 2009-01-21 2015-06-30 Warsaw Orthopedic, Inc. Spinal nucleus replacement implants
US9192655B2 (en) * 2009-03-12 2015-11-24 New Jersey Institute Of Technology System and method for a hydrogel and hydrogel composite for cartilage repair applications
US20100256646A1 (en) * 2009-04-01 2010-10-07 Frank Pinal Orthobiologics delivery tool

Patent Citations (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5755797A (en) * 1993-04-21 1998-05-26 Sulzer Medizinaltechnik Ag Intervertebral prosthesis and a process for implanting such a prosthesis
US20080140084A1 (en) * 1994-01-26 2008-06-12 Kyphon Inc. Methods for treating a fractured and/or diseased and/or weakened bone
US6899719B2 (en) * 1994-01-26 2005-05-31 Kyphon Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
US7077865B2 (en) * 1994-05-06 2006-07-18 Disc Dynamics, Inc. Method of making an intervertebral disc prosthesis
US7001431B2 (en) * 1994-05-06 2006-02-21 Disc Dynamics, Inc. Intervertebral disc prosthesis
US5571189A (en) * 1994-05-20 1996-11-05 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US5549679A (en) * 1994-05-20 1996-08-27 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US5562736A (en) * 1994-10-17 1996-10-08 Raymedica, Inc. Method for surgical implantation of a prosthetic spinal disc nucleus
US6402784B1 (en) * 1997-07-10 2002-06-11 Aberdeen Orthopaedic Developments Limited Intervertebral disc nucleus prosthesis
US6224630B1 (en) * 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
US6132465A (en) * 1998-06-04 2000-10-17 Raymedica, Inc. Tapered prosthetic spinal disc nucleus
US6746485B1 (en) * 1999-02-18 2004-06-08 St. Francis Medical Technologies, Inc. Hair used as a biologic disk, replacement, and/or structure and method
US6602291B1 (en) * 1999-04-05 2003-08-05 Raymedica, Inc. Prosthetic spinal disc nucleus having a shape change characteristic
US6110210A (en) * 1999-04-08 2000-08-29 Raymedica, Inc. Prosthetic spinal disc nucleus having selectively coupled bodies
US6245107B1 (en) * 1999-05-28 2001-06-12 Bret A. Ferree Methods and apparatus for treating disc herniation
US7507243B2 (en) * 1999-08-18 2009-03-24 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US8231678B2 (en) * 1999-08-18 2012-07-31 Intrinsic Therapeutics, Inc. Method of treating a herniated disc
US7998213B2 (en) * 1999-08-18 2011-08-16 Intrinsic Therapeutics, Inc. Intervertebral disc herniation repair
US6508839B1 (en) * 1999-08-18 2003-01-21 Intrinsic Orthopedics, Inc. Devices and methods of vertebral disc augmentation
US7553329B2 (en) * 1999-08-18 2009-06-30 Intrinsic Therapeutics, Inc. Stabilized intervertebral disc barrier
US7563282B2 (en) * 1999-08-18 2009-07-21 Intrinsic Therapeutics, Inc. Method of supporting nucleus pulposus
US6425919B1 (en) * 1999-08-18 2002-07-30 Intrinsic Orthopedics, Inc. Devices and methods of vertebral disc augmentation
US7883527B2 (en) * 1999-09-20 2011-02-08 Nuvasive, Inc. Annulotomy closure device and related methods
US7901430B2 (en) * 1999-09-20 2011-03-08 Nuvasive, Inc. Annulotomy closure device and related methods
USRE42837E1 (en) * 1999-09-30 2011-10-11 Replication Medical, Inc. Spinal nucleus implant
US6602261B2 (en) * 1999-10-04 2003-08-05 Microvention, Inc. Filamentous embolic device with expansile elements
US6419704B1 (en) * 1999-10-08 2002-07-16 Bret Ferree Artificial intervertebral disc replacement methods and apparatus
US6371990B1 (en) * 1999-10-08 2002-04-16 Bret A. Ferree Annulus fibrosis augmentation methods and apparatus
US6969404B2 (en) * 1999-10-08 2005-11-29 Ferree Bret A Annulus fibrosis augmentation methods and apparatus
US20020173851A1 (en) * 1999-12-06 2002-11-21 Mckay William F. Intervertebral disc treatment devices and methods
US7318840B2 (en) * 1999-12-06 2008-01-15 Sdgi Holdings, Inc. Intervertebral disc treatment devices and methods
US7931689B2 (en) * 2000-02-28 2011-04-26 Spineology Inc. Method and apparatus for treating a vertebral body
US20040215343A1 (en) * 2000-02-28 2004-10-28 Stephen Hochschuler Method and apparatus for treating a vertebral body
US6332894B1 (en) * 2000-03-07 2001-12-25 Zimmer, Inc. Polymer filled spinal fusion cage
US6869445B1 (en) * 2000-05-04 2005-03-22 Phillips Plastics Corp. Packable ceramic beads for bone repair
US20020068974A1 (en) * 2000-07-21 2002-06-06 Kuslich Stephen D. Expandable porous mesh bag device and methods of use for reduction, filling, fixation and supporting of bone
US20100268231A1 (en) * 2000-07-21 2010-10-21 Spineology, Inc. Expandable porous mesh bag device and methods of use for reduction, filling, fixation and supporting of bone
US7520900B2 (en) * 2000-08-30 2009-04-21 Warsaw Orthopedic, Inc. Intervertebral disc nucleus implants and methods
US6620196B1 (en) * 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US6893466B2 (en) * 2000-08-30 2005-05-17 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US7618461B2 (en) * 2000-08-30 2009-11-17 Warsaw Orthopedic, Inc. Composite intervertebral disc implants and methods for forming the same
US20030220695A1 (en) * 2000-09-26 2003-11-27 Sevrain Lionel C. Inter-vertebral disc prosthesis for lumbar rachis through posterior surgery thereof
US20020045942A1 (en) * 2000-10-16 2002-04-18 Ham Michael J. Procedure for repairing damaged discs
US7896920B2 (en) * 2000-10-24 2011-03-01 Cryolife, Inc. In situ bioprosthetic filler and method, particularly for the in situ formation of vertebral disc bioprosthetics
US7445634B2 (en) * 2000-10-27 2008-11-04 Warsaw Orthopedic, Inc. Annulus repair systems and methods
US20040109823A1 (en) * 2000-11-16 2004-06-10 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
US20020077701A1 (en) * 2000-12-15 2002-06-20 Kuslich Stephen D. Annulus-reinforcing band
US7056345B2 (en) * 2000-12-15 2006-06-06 Spineology, Inc. Annulus-reinforcing band
US20020147497A1 (en) * 2001-04-06 2002-10-10 Integrated Vascular Systems, Inc. Methods for treating spinal discs
US7666205B2 (en) * 2001-04-19 2010-02-23 Synthes Usa, Llc Inflatable device and method for reducing fractures in bone and in treating the spine
US7717956B2 (en) * 2001-05-25 2010-05-18 Conformis, Inc. Joint arthroplasty devices formed in situ
US7641691B2 (en) * 2001-06-29 2010-01-05 The Regents Of The University Of California Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs
US7601157B2 (en) * 2001-11-01 2009-10-13 Spine Wave, Inc. Devices and methods for the restoration of a spinal disc
US20030195630A1 (en) * 2002-04-10 2003-10-16 Ferree Bret A. Disc augmentation using materials that expand in situ
US7223227B2 (en) * 2002-05-13 2007-05-29 Pflueger D Russell Spinal disc therapy system
US7563284B2 (en) * 2002-08-15 2009-07-21 Synthes Usa, Llc Intervertebral disc implant
US7803188B2 (en) * 2002-08-27 2010-09-28 Warsaw Orthopedic, Inc. Systems and methods for intravertebral reduction
US20040054413A1 (en) * 2002-09-16 2004-03-18 Howmedica Osteonics Corp. Radiovisible hydrogel intervertebral disc nucleus
US20060255503A1 (en) * 2002-09-16 2006-11-16 Howmedica Osteonics Corp. Radiovisible hydrogel intervertebral disc nucleus
US7713303B2 (en) * 2002-09-18 2010-05-11 Warsaw Orthopedic, Inc. Collagen-based materials and methods for augmenting intervertebral discs
US7887593B2 (en) * 2002-09-18 2011-02-15 Warsaw Orthopedic, Inc. Method of implanting natural tissue within the vertebral disc nucleus space using a drawstring
US20040059417A1 (en) * 2002-09-25 2004-03-25 Medicinelodge, Inc. Apparatus and method for the in-situ formation of a structural prosthesis
US6932843B2 (en) * 2002-09-25 2005-08-23 Medicinelodge, Inc. Apparatus and method for the in-situ formation of a structural prosthesis
US20050055094A1 (en) * 2002-11-05 2005-03-10 Kuslich Stephen D. Semi-biological intervertebral disc replacement system
US8012211B2 (en) * 2002-11-05 2011-09-06 Spineology, Inc. Semi-biological intervertebral disc replacement system
US20090125110A1 (en) * 2002-11-05 2009-05-14 Kuslich Stephen D Semi-biological intervertebral disc replacement system
US7901460B2 (en) * 2003-06-02 2011-03-08 Warsaw Orthopedic, Inc. Intervertebral disc implants and methods for manufacturing and using the same
US20050027358A1 (en) * 2003-07-29 2005-02-03 Loubert Suddaby Inflatable nuclear prosthesis
US7309359B2 (en) * 2003-08-21 2007-12-18 Warsaw Orthopedic, Inc. Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs
US7465318B2 (en) * 2004-04-15 2008-12-16 Soteira, Inc. Cement-directing orthopedic implants
US20080051800A1 (en) * 2004-05-03 2008-02-28 Robert Diaz Method and device for reducing susceptibility to fractures in vertebral bodies
US20080132899A1 (en) * 2004-05-17 2008-06-05 Shadduck John H Composite implant and method for treating bone abnormalities
US8118874B2 (en) * 2004-05-21 2012-02-21 Synthes Usa, Llc Replacement or supplementation of a nucleus pulposus using a hydrogel
US8110003B2 (en) * 2004-09-09 2012-02-07 University Of South Florida Prostheses for spine discs having fusion capability
US7682393B2 (en) * 2004-10-14 2010-03-23 Warsaw Orthopedic, Inc. Implant system, method, and instrument for augmentation or reconstruction of intervertebral disc
US20060265077A1 (en) * 2005-02-23 2006-11-23 Zwirkoski Paul A Spinal repair
US20060253202A1 (en) * 2005-05-05 2006-11-09 Lipov Eugene G Vertebral disc implant in fiber form
US7988735B2 (en) * 2005-06-15 2011-08-02 Matthew Yurek Mechanical apparatus and method for delivering materials into the inter-vertebral body space for nucleus replacement
US7618457B2 (en) * 2005-08-10 2009-11-17 Zimmer Spine, Inc. Devices and methods for disc nucleus replacement
US20070055272A1 (en) * 2005-08-16 2007-03-08 Laurent Schaller Spinal Tissue Distraction Devices
US8287595B2 (en) * 2005-08-26 2012-10-16 Synthes Usa, Llc Hydrogel balloon prosthesis for nucleus pulposus
US20070093899A1 (en) * 2005-09-28 2007-04-26 Christof Dutoit Apparatus and methods for treating bone
US20070150059A1 (en) * 2005-12-22 2007-06-28 Depuy Spine, Inc. Methods and devices for intervertebral augmentation using injectable formulations and enclosures
US7699894B2 (en) * 2005-12-22 2010-04-20 Depuy Spine, Inc. Nucleus pulposus trial device and technique
US7534268B2 (en) * 2006-01-13 2009-05-19 Zimmer Spine, Inc. Devices and methods for disc replacement
US7645301B2 (en) * 2006-01-13 2010-01-12 Zimmer Spine, Inc. Devices and methods for disc replacement
US7959676B2 (en) * 2006-02-13 2011-06-14 Lanx, Inc. Method and apparatus for intervertebral disc support and repair
US8163018B2 (en) * 2006-02-14 2012-04-24 Warsaw Orthopedic, Inc. Treatment of the vertebral column
US7520888B2 (en) * 2006-02-14 2009-04-21 Warsaw Orthopedic, Inc. Treatment of the vertebral column
US8133279B2 (en) * 2006-04-27 2012-03-13 Warsaw Orthopedic, Inc. Methods for treating an annulus defect of an intervertebral disc
US8092536B2 (en) * 2006-05-24 2012-01-10 Disc Dynamics, Inc. Retention structure for in situ formation of an intervertebral prosthesis
US7959683B2 (en) * 2006-07-25 2011-06-14 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US7758649B2 (en) * 2006-08-04 2010-07-20 Integrity Intellect Inc. Reversibly deformable implant
US7879100B2 (en) * 2007-01-19 2011-02-01 Spinemedica, Llc Methods and systems for forming implants with selectively exposed mesh for fixation and related implants
US20080249604A1 (en) * 2007-03-30 2008-10-09 Brian Donovan Apparatus and method for medical procedures within a spine
US8052728B2 (en) * 2007-07-31 2011-11-08 Zimmer Spine, Inc. Method for stabilizing a facet joint
US8282681B2 (en) * 2007-08-13 2012-10-09 Nuvasive, Inc. Bioresorbable spinal implant and related methods
US20090125031A1 (en) * 2007-11-14 2009-05-14 Cook Incorporated Method and bone cement substitute kit for stabilizing a collapsed vertebra of a patient

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9433404B2 (en) 2012-10-31 2016-09-06 Suture Concepts Inc. Method and apparatus for closing fissures in the annulus fibrosus
US9949734B2 (en) 2012-10-31 2018-04-24 Suture Concepts Inc. Method and apparatus for closing a fissure in the annulus of an intervertebral disc, and/or for effecting other anatomical repairs and/or fixations

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