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Blood treatment dialyzer/filter for permitting gas removal

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Publication number
US20110126714A1
US20110126714A1 US13025306 US201113025306A US20110126714A1 US 20110126714 A1 US20110126714 A1 US 20110126714A1 US 13025306 US13025306 US 13025306 US 201113025306 A US201113025306 A US 201113025306A US 20110126714 A1 US20110126714 A1 US 20110126714A1
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Prior art keywords
blood
filter
header
space
port
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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US13025306
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James M. Brugger
Martin Stillig
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NxStage Medical Inc
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NxStage Medical Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3627Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D19/00Degasification of liquids
    • B01D19/0021Degasification of liquids by bringing the liquid in a thin layer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D19/00Degasification of liquids
    • B01D19/0042Degasification of liquids modifying the liquid flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis, ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/20Accessories; Auxiliary operations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis, ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24Dialysis ; Membrane extraction
    • B01D61/30Accessories; Auxiliary operations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02Hollow fibre modules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D65/00Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2313/00Details relating to membrane modules or apparatus
    • B01D2313/06External membrane module supporting or fixing means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2313/00Details relating to membrane modules or apparatus
    • B01D2313/18Specific valves

Abstract

A configuration of a blood microtubular filter/dialyzer used in many kinds of renal replacement therapy systems can provide a highly effective mechanism for removing air from the blood circuit of such systems. Air is removed from an outlet header space of the filter avoiding the need for a bubble trap or settling chamber such as a drip chamber.

Description

    CROSS REFERENCE TO RELATED APPLICATIONS
  • [0001]
    This application is a continuation of U.S. patent application Ser. No. 11/163708, filed Oct. 27, 2005, now pending, which claims the benefit of U.S. Provisional Application Ser. No. 60/622,863, filed Oct. 28, 2004, both of which are incorporated by reference herein in their entireties.
  • BACKGROUND
  • [0002]
    One of the problems with fluid circuits in blood treatment systems is entrained air (bubbles) in treatment fluids, infusate, or blood. Treatment systems normally have air detectors to prevent air from being injected into a patient, either because a venous line carrying blood back to the patient contains air or because an infusate line, such as the replacement fluid line of a hemofiltration system, contains air. It is desirable for the air detectors to be made sufficiently sensitive to prevent the rare instances of long trains of air bubbles being injected into a patient. But sensitivity high enough to prevent long thin trains of bubbles may be high enough to alarm very small amounts of air which pose no risk. In other words, sensitive air detectors alarm on a lot of fall positives if they protect against all possible risks.
  • [0003]
    A prior art approach has been to remove as much air from a protected fluid circuit as possible. Putting air traps in fluid circuits, particularly blood lines, has drawbacks. Air-settling chambers necessarily involve stagnant flow, which creates a risk of fowling clots (e.g., for blood) or sedimentation or other concentration of entrained material (e.g. medication).
  • [0004]
    Another prior art problem is stagnant flow in the headers of microtubular filter used for most dialyzers and hemofilters. This is a particular problem in the venous header where flow from many microtubules coalesces into a single slow moving flow.
  • [0005]
    The inventive embodiments provide various other features and advantages in addition to or in lieu of those discussed above and below. Many of these features and advantages are apparent from the description below with reference to the following drawing.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0006]
    FIG. 1 is a cross-section view of a filter usable in a variety of different types of blood treatment systems oriented to trap air in one or two header portions of the filter.
  • [0007]
    FIGS. 2A through 2C illustrate holders for use with the filter device embodiment described herein, including a particular example of application to a blood treatment device such as that of FIG. 1.
  • [0008]
    FIG. 2D illustrates an example of a holder feature to restrict orientations of a filter ensure that the filter is oriented with respect to the force of gravity.
  • [0009]
    FIG. 3 illustrates a filter similar to that of FIG. 1 but with a header port for removing air and/or disrupting or cleaning clots.
  • [0010]
    FIG. 4A illustrates an assembly for use with the port of FIG. 3 for removing air and/or disrupting or cleaning clots.
  • [0011]
    FIG. 4B illustrates a drip-chamber (or bubble trap) embodiment similar to the embodiment of FIG. 4A.
  • [0012]
    FIG. 5 illustrates a header cap with a hydrophobic membrane for automatically venting air.
  • [0013]
    FIGS. 6A through 9B illustrate a method for manufacturing a filter having a two-piece header caps that allow the use of a cylinder for a majority of the filter.
  • [0014]
    FIGS. 10A, 10B, and 11 illustrate the filter whose manufacture is described with respect to FIGS. 6A through 9B.
  • [0015]
    FIG. 12 shows an alternative configuration for connecting a dialysate manifold with a tubular body of the a filter according to an embodiment of the invention.
  • [0016]
    FIG. 13 illustrates a single element header component that uses a simple tube for the dialysate portion.
  • DETAILED DESCRIPTION OF THE DRAWINGS
  • [0017]
    FIG. 1 is a cross-section view of a filter usable in a variety of different types of blood treatment systems oriented to trap air in one or two header portions of the filter. A filter 100, which may be a dialyzer, hemofilter, hemodiafilter, or any other compatible blood treatment has a bundle of tubular media 132 connecting an arterial 160 and venous 155 head space which is isolated from a filtrate space 130. Blood flows through ports 122 and 124 in header caps 110 and 136 as indicated by arrows 118 and 112 into and out of the arterial 160 and venous 155 head spaces, respectively. A cylindrical filter body 128 encloses the filtrate space 130 and contains filtrate (e.g., dialyzer) ports 126 and 120. Arterial and venous headers 142 and 134 isolate the filtrate space 130 from the respective arterial 160 and venous 155 head spaces.
  • [0018]
    The orientation of the filter 100 with respect to the pull of gravity is shown with the understanding that gravity is assumed to pull down with respect to the profile orientation of the drawing page. If any air is entrained in the blood, it may settle in pockets 151 and 153 in the arterial 160 and venous 155 head spaces as indicated by air/liquid interfaces 152 and 150. The flow of blood through the arterial 160 and venous 155 head spaces is extremely slow due to the very small cross-sectional areas of the filter fibers in the bundle 132. As a result, the arterial 160 and venous 155 head spaces are an idea place for air to settle out. With the indicated orientation, with blood outlet 124 pointing down and away from the pocket 151. Since the blood moves at a very slow rate in the arterial 160 and venous 155 head spaces, there is little risk of reentrainment and air settles out very effectively.
  • [0019]
    Air trapped in pocket 153 may travel through filter fibers in bundle 132 up to venous head space 155 and accumulate in pocket 151. Since the pocket 153 is located near the top of the arterial head space 160, air will tend to travel up a few of the fibers closest to the top and collect in the pocket 151 without mixing in with blood. This keeps the vast majority of fibers filled with blood.
  • [0020]
    FIGS. 2A through 2C illustrate holder variations for the filter embodiments of the present patent disclosure. The variations are intended to illustrate examples and not intended to be comprehensive or limiting. In FIG. 2A, a holder 175 of a blood treatment machine orients a filter such as that of FIG. 1 and those of the further filter embodiments described below. The holder 175 may be attached at a base thereof (not shown separately) to a blood treatment machine 172 which may contain actuators, sensors, and control elements as well as a fluid circuit, here illustrated as a cartridge 180 enclosed between two parts 171 and 172 of the blood treatment machine 172. A filter 100 that is preconnected to the fluid circuit can easily be mounted in such an apparatus. The holder 175 may be articulating to allow for some movement or change of orientation of the filter 100 and is preferably a spring-tensioned clamp that allows for one-handed insertion of a filter 100. In an alternative embodiment, the holder 175 may be attached to the 180 cartridge such that its orientation is obtained when the cartridge 180 is positioned with respect to the blood treatment machine 170. In FIG. 2B, a holder 194 is integrated into a disposable unit 190 (such as the fluid circuit cartridge of FIG. 2A). For example, the holder 194 may be made of wire which is connected to a plastic panel support 191 of the disposable unit. Examples of such disposable units are disclosed in U.S. Pat. No. 6,955,655 for “Hemofiltration system” and U.S. Pat. No. 6,579,253 for “Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge,” each of which is hereby incorporated by reference as if full set forth in its entirety herein and U.S. patent application Ser. No. 10/650,935 published as US 2004-0069709, which is incorporated by reference above. The holder 194 supports a filter 192 such that when the disposable unit 190 is mounted, in a treatment device such as 170, the filter 192 is held at an angle as shown. Another alternative arrangement shown in FIG. 2C is to provide a separate support 178 that is attached, or attachable, to a support 176.
  • [0021]
    FIG. 2D illustrates an example of a holder feature to restrict orientations of a filter ensure that the filter is oriented with respect to the force of gravity. The view is a sectional view. In the example, the filter 166 has tabs 162 and 164 that prevent the filter 166 from being received fully within a flexible trough 168 which functions as a holder. This may be confirmed by inspection. The flexible trough 168 allows the filter 166 body to fit into it fully in only one orientation, the holder providing an urging force that keeps the filter 166 in place when inserted. Note that the example illustrated in FIG. 2D is only one of many devices that may be used to restrict the orientation of the filter when attached to a holder and is not intended to be limiting of the scope of any of the inventions described in the present disclosure.
  • [0022]
    FIG. 3 illustrates a filter similar to that of FIG. 1 but with a header cap 210 having an integrated header port 200 for removing air and/or disrupting or cleaning clots. Tubing 265 may be connected to the port and provided with a clamp 260. The clamp 260 may be released, at intervals, by an operator, to vent air from the air pocket 251 and re-engaged to prevent blood loss. The clamp 260 may be a normally-closed type clamp with a strong spring so that it reclamps tubing 265 when released. The tubing 265 may be capped with a microporous filter end cap 253 to prevent any contamination re-entering the blood in the venous head space 155. The entire assembly that includes the filter 100, tubing 265, and microporous filter end cap 253 may be fused, sealed, and sterilized as a unit. In addition the same may be fused, sealed and sterilized as a unit with an entire treatment circuit, combining it with the circuit described in U.S. patent application Ser. No. 10/650,935 published as US 2004-0069709, which is hereby incorporated by reference as if full set forth in its entirety herein. With this combination, the entire circuit may be isolated from contamination.
  • [0023]
    FIG. 4A illustrates an assembly 350 for use with the port of FIG. 3 for removing air and/or disrupting or cleaning clots. The port 200 has a tube 310 connecting the venous head space 155 with a multi-way valve (e.g., a stopcock as shown) 312. The multi-way valve 312 is further connected to a syringe 320 and tubing 375 connecting a supply of blood normal saline 375, heparin, drug, or other medicament (such as from a tube 360 and bag 365) such as anticoagulants, drugs, etc. The multi-way valve allows the syringe to be connected, in a first position, to draw saline from the source of saline 375 and, in a second position, to draw air from the venous head space 155. In the second position, saline may be pushed into the head space 155 to clear clots or for prophylaxis by injecting medicament, for example, an anticoagulant such as heparin. In an illustrative usage method, the multi-way valve 312 is set in the second position and air is drawn from the head space 155. Then it is set in the first position and saline is drawn into the syringe 320. Then the multi-way valve 312 is set in the second position again and saline (or saline and heparin) is injected into the venous head space 155. The apparatus including the multi-way valve 312, syringe 320, tubing 310, 375, 360 and clamp 260 may be pre-attached to the filter 100 and presterilized as a unit.
  • [0024]
    Note that besides using the multi-way valve and bag 365 to draw air from the header of a filter and inject medicaments into the filter header, the same devices may be used in connection with an air trap or drip chamber. Referring to FIG. 4B, a drip chamber 393 (which could also be a bubble trap or other similar device in which air may accumulate and possibly be vented), has an inlet 391 and an outlet 394. A connection 392 to the top of the drip chamber 393 may be connected to the line 310 shown in FIG. 4A and used in the manner described for removing air and/or injecting medicaments.
  • [0025]
    FIG. 5 illustrates a header cap 210 with cover 280 sealed to and covering the header port 200. The cover includes a hydrophobic membrane 285 that allows air in the head space 155 to vent automatically while preventing any contamination from entering.
  • [0026]
    Referring to FIGS. 6A and 6B, a method for manufacturing a filter design that incorporates features of the foregoing examples begins with the insertion of a filter fiber bundle 420 into a cylindrical tube 405 which fauns part of a housing (discussed with reference to FIG. 11). The tube 405 is a straight tube with no other structural features, in the present example. As such, the tube 405 may be a thin walled structure allowing material to be saved. In addition, it may be made of a material that is not necessarily injection moldable, as filter housings generally are. A preferred material is glycol-modified polyethylene terephthalate, a copolyester (PETG) which may be a clear amorphous thermoplastic with high stiffness, hardness, and toughness as well as good impact strength. Other advantages of using a tube for the main part of the housing will become clear from the further description below. Note that in the drawing only one end of the tube is shown in the present and following figures, but a complementary operation may be performed at an opposite end of the tube 405 such that a mirror-image structure is obtained.
  • [0027]
    The filter fiber membrane bundle 420 may be inserted such that the fibers 415 extend beyond the end 407 of the tube 405 as indicated at 445. Referring now to FIGS. 7A and 7 B, the resulting combination 430 of tube 405 and filter fibers 420 may be inserted in a dialysis cap 435. Note that the term “dialysis cap” is for convenience is not intended to limit the scope of the invention to the manufacture of a dialyzer. The outer surface of the tube 405 lies adjacent an inner annular surface 440 of the dialysis cap and a 450 bond is formed by thermal welding or sealing using adhesive, solvent, or filling type bonding agent such as urethane to form a completed structure 480. A symmetrical structure is formed at the opposite end so that both ends of the tube 405 have a dialysate cap 435.
  • [0028]
    Referring now to FIGS. 8A and 8B, potting caps (not shown) are placed over the ends of the structure 480 and the ends of the fiber bundle are potted as according methods that are known in the art of manufacturing filters. A preferred method of potting is described in U.S. Pat. No. 6,872,346 for a “Method and apparatus for manufacturing filters,” which is hereby incorporated by reference as if fully set forth in its entirety herein. The result of potting is the creation of a sealed end of potting material indicated at 440 which, after hardening, is cut along a planar surface indicated at 460. The cut 460 is done in such a way that the end of the filter fibers 420 are open at the surface 465 forming. A portion of the dialysate cap 435 may be trimmed off in the process of cutting 460, as illustrated, although it will be apparent to those skilled in the art that this is not essential and instead, the fibers 420 could extend beyond the end of the dialysate cap 435 before potting such that the fibers 420 can be opened by cutting without cutting the dialysis cap 435. The completed end portion is shown in FIG. 8B, and as discussed, a symmetrical end portion may be completed at the opposite end (not shown here).
  • [0029]
    Referring now to FIGS. 9A through 11, the two ends 600 A and 600 B of a single tube structure are indicated. Respective blood caps 505 and 605 are fitted to the ends 600 A and 600 B of the structure 480. Each blood cap has a respective blood port 510, 610 and one of the blood caps has a secondary port 611 which will be recognized from the discussion of embodiments such as shown and discussed with respect to FIGS. 3 through 5. The blood caps 505 and 605 have respective header spaces 545, 645 that are preferably hydraulically shaped to ensure that no, or a minimal number of, dead (stagnant flow of blood) spaces arise when in use. In the embodiment shown, a rim 515 fits into an annular recess 470 (or rim 615 into annular recess 471). Prior to fitting the blood caps 505 and 605, a bead 605, 606, 607, 608 of adhesive or sealing material may be applied or injected in the annular recesses 470 and 471 to form a bond between the structure 480 and the respective blood caps 505 and 605. The bonding may be done by thermal, friction, solvent welding, compression bonding, or other technique. Dialysate ports 30 and 531 in the dialysate caps 435 and 425, respectively, allow dialysate to flow into and out of the space occupied by bundle 420 and in contact with the external surfaces of the filter bundle 420. For a hemofilter or other kinds of filters, such as sterile filters, reverse osmosis filters, ultrafilters, etc.; only one “dialysate” port would be required. Blood ports 510 and 610 in blood caps 505 and 605, respectively, supply blood into, and be recovered from, the header spaces 545 and 645, respectively. Air can be removed from air removal/access (secondary) port 611. As explained above, removal/access port 611 can also be used for injection of anticoagulants, drugs, or other medicaments.
  • [0030]
    As best seen in FIGS. 10A and 10B, a small gap 685, 686 is provided between the end 407 (FIGS. 6A, 7A, 8 A) of the tube 405 (FIGS. 6A, 6B) and the surface of the potting 440 to allow dialysate to flow into the space occupied by the filter bundle 420. The dialysate (or filtrate, depending on the application) is distributed by an annular dialysate manifold space 626, 626. Referring momentarily to FIG. 12, it is noted that instead of providing for the gap 685, 686 in the manner described, the fiber bundle may be extended all the way to the end 407 of the tube 405 and openings 705 can be provided to perform the function of the openings 685, 686. The same features provide for extraction of filtrate or dialysate or other fluid depending on the application. FIG. 11 shows a complete filter unit. One of the benefits of the design is that it makes it possible to confine the capital expense associated with injection molding to the dialysate and blood header reducing first costs in new filter designs. In addition, the design allows the tubular portion to be lengthened and shorted without requiring major design and manufacturing changes. Note that although injection molding is not contemplated to be a requirement for the practice of the invention or all its embodiments, it is a preferred means for achieving the high precision and economies of scale for articles of manufacture such as dialyzers, filters, and hemofilters, as well as other applications of the disclosed embodiments.
  • [0031]
    Referring to FIG. 13, the benefit of using a tube for the filtrate/dialysate portion of the filter can be obtained by using a single-element header cap rather than separate “dialysate” and “blood” caps. In the example shown, a one-piece cap 725 has an annular dialysate manifold 740 that is sealed by O-rings 747 against the surface of a tube 760. A blood header space 732 is in communication with a blood port 730 and the dialysate manifold 740 is in communication with a dialysate port 735. Slits 750 (configured such as illustrated in FIG. 11) allow fluid communication between the dialysate manifold 740 and the external surfaces of the fiber bundle 733. A potting plug 745, in addition to performing its normal function, serves to reinforce the cylindrical structure of the tube 760 against the pressure of the O-ring 747 seals. In this embodiment, a tube is permitted to be used with a single-element cap 725 structure providing many of the benefits of the inventions discussed above.
  • [0032]
    A tension band 757 may be used to ensure a good seal and provide a final shape to the one-piece cap 725 if made of a somewhat compliant resin to allow it to be removed from an injection mold despite the recess defined by the dialysate manifold 740. Alternatively, the one-piece cap 725 may have a discontinuous dialysate manifold that allows it to be created without requiring the cap to yield, the cap could be machined rather than molded, or the cap could be made of two molded pieces that are assembled into a single cap. Many variations are possible.
  • [0033]
    It will be understood that while the invention has been described above in conjunction with a few exemplary embodiments, the description and examples are intended to illustrate and not limit the scope of the invention. That which is described herein with respect to the exemplary embodiments can be applied to the measurement of many different formation characteristics. Thus, the scope of the invention should only be limited by the following claims.

Claims (21)

1-18. (canceled)
19. A system for removing gas from blood, the system comprising:
a blood processing device including a microtubular fiber filter having a plurality of filter fibers with ends opening into an inlet header space and an outlet header space, the inlet header space including an inlet port and the outlet header space including an outlet port and a gas release port, the outlet port and the gas release port lying at opposite ends of the outlet header space,
the blood processing device being configured to allow blood entering through the inlet port into the inlet header space to flow through the plurality of filter fibers into the outlet header space and out the outlet port, and further configured to allow gas to collect in a portion of the inlet header space so as to be conveyed through a subset of the plurality of filter fibers into the outlet header space,
the inlet and outlet header spaces having sizes and shapes such that a shear rate of blood flow is sufficient to prevent stagnant flow regions from arising in the inlet and outlet header spaces; and
a holder configured to support said blood processing device in a position and orientation such that gas in the outlet header space accumulates in a portion of the outlet header space which is adjacent the gas release port, the gas release port being configured to periodically release the accumulated gas.
20. The system of claim 19, wherein the filter has a longitudinal housing with a longitudinal axis and is supported by the holder so as to be at an angle with respect to the vertical.
21. The system of claim 19, further comprising a valve connected to said gas release port and pre-connected and sterilized together with said blood processing device, the valve being configured to permit gas to egress from the outlet header space without permitting blood to egress from the outlet header space.
22. The system of claim 19, further comprising a stopcock connected to said gas release port and pre-connected and sterilized together with said blood processing device.
23. The system of claim 19, further comprising a syringe connected to said gas release port and pre-connected and sterilized together with said blood processing device.
24. The system of claim 19, wherein the holder is configured to orient said blood processing device such that said outlet port is lower, with respect to a direction of gravity, than said gas release port.
25. The system of claim 19, wherein the inlet and outlet header spaces have a hydraulic shape to eliminate stagnant flow of blood.
26. The system of claim 19, wherein the gas release port further includes a microporous filter to prevent contamination from entering the outlet header space.
27. The system of claim 19, wherein the portion of the inlet header space where gas collects is connected to the portion of the outlet header space where gas accumulates before release by said subset of the filter fibers.
28. The system of claim 19, wherein the holder is configured to hold the blood processing device so that the inlet port and the outlet port are oriented below the gas release port.
29. The system of claim 19, wherein the holder is fixedly attachable to a blood treatment machine.
30. The system of claim 19, wherein the blood processing device is one of a blood dialyzer and a hemofilter processing element.
31. The system of claim 19, wherein the gas release port is further configured to permit adding or removing biocompatible non-blood fluid.
32. The system of claim 19, wherein the portion of the inlet header space where gas collects is opposite the inlet port.
33. A system for processing blood, the system comprising:
a blood processing element including filter media, the filter media being configured to convey blood and air from an inlet header chamber into an outlet header chamber through the filter media,
the blood processing element including the outlet header chamber at a position where blood and air exit said filter media, said outlet header chamber having at least one outlet; and
a holder configured to support said processing element in a preferred position and orientation, wherein the preferred position and orientation is such that air can accumulate in said outlet header chamber in a position remote from said outlet,
wherein the holder includes a flexible holding portion configured to accept the blood processing element only in the preferred position and orientation.
34. A holding device for holding a blood filtering element in a preferred orientation relative to a blood processing machine, the holding device comprising:
a flexible holding portion to receive the blood filtering element in a predetermined orientation;
an attachment portion to detachably attach the flexible holding portion to the blood processing machine, the blood processing machine including a fluid circuit,
wherein when the attachment portion is attached to the blood processing machine, the blood filtering element is positioned in a preferred orientation relative to the blood processing machine, and
wherein the preferred orientation is such that gas accumulates in a specific portion of the blood filtering element.
35. The holding device of claim 34, wherein the blood filtering element is connected to the fluid circuit before the attachment portion is attached to the blood processing machine.
36. The holding device of claim 34, wherein the fluid circuit includes a cartridge enclosed between two separate parts of the blood treatment machine, and the holding device is configured to be detachably attached to the cartridge so that the preferred orientation of the blood filtering element relative to the blood processing machine is determined by the attachment of the holding device to the cartridge.
37. The holding device of claim 34, wherein the holding device is integral with the blood processing machine.
38. The holding device of claim 34,
wherein,
the blood filtering element includes a microtubular fiber filter having a plurality of filter fibers with ends opening into an inlet header space and an outlet header space, the inlet header space including an inlet port and the outlet header space including an outlet port and a gas release port, the outlet port and the gas release port lying at opposite ends of the outlet header space, the blood filtering element being configured to allow blood entering through the inlet port into the inlet header space to flow through the plurality of filter fibers into the outlet header space and out the outlet port, and further configured to allow gas to collect in a portion of the inlet header space so as to be conveyed through a subset of the plurality of filter fibers into the outlet header space, the inlet and outlet header spaces having sizes and shapes such that a shear rate of blood flow is sufficient to prevent stagnant flow regions from arising in the inlet and outlet header spaces, and
the preferred orientation is such that gas accumulates in a portion of the outlet header space adjacent the gas release port.
US13025306 2004-10-28 2011-02-11 Blood treatment dialyzer/filter for permitting gas removal Abandoned US20110126714A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US62286304 true 2004-10-28 2004-10-28
US11163708 US20060091058A1 (en) 2004-10-28 2005-10-27 Blood Treatment Dialyzer/Filter Design to Remove Entrained Gas and Add Medicaments
US12432507 US7901579B2 (en) 2004-10-28 2009-04-29 Blood treatment dialyzer/filter for permitting gas removal
US13025306 US20110126714A1 (en) 2004-10-28 2011-02-11 Blood treatment dialyzer/filter for permitting gas removal

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13025306 US20110126714A1 (en) 2004-10-28 2011-02-11 Blood treatment dialyzer/filter for permitting gas removal

Publications (1)

Publication Number Publication Date
US20110126714A1 true true US20110126714A1 (en) 2011-06-02

Family

ID=36319501

Family Applications (6)

Application Number Title Priority Date Filing Date
US11577126 Abandoned US20100096311A1 (en) 2004-10-28 2005-09-16 Blood treatment dialyzer/filter design to trap entrained air in a fluid circuit
US11163703 Abandoned US20060091057A1 (en) 2004-10-28 2005-10-27 Blood Treatment Dialyzer/Filter Design to Trap and Remove Entrained Gas
US11163708 Abandoned US20060091058A1 (en) 2004-10-28 2005-10-27 Blood Treatment Dialyzer/Filter Design to Remove Entrained Gas and Add Medicaments
US11163702 Granted US20060091056A1 (en) 2004-10-28 2005-10-27 Blood Treatment Filter Design to Trap Entrained Gas in a Blood Circuit
US12432507 Active 2026-03-01 US7901579B2 (en) 2004-10-28 2009-04-29 Blood treatment dialyzer/filter for permitting gas removal
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US11163708 Abandoned US20060091058A1 (en) 2004-10-28 2005-10-27 Blood Treatment Dialyzer/Filter Design to Remove Entrained Gas and Add Medicaments
US11163702 Granted US20060091056A1 (en) 2004-10-28 2005-10-27 Blood Treatment Filter Design to Trap Entrained Gas in a Blood Circuit
US12432507 Active 2026-03-01 US7901579B2 (en) 2004-10-28 2009-04-29 Blood treatment dialyzer/filter for permitting gas removal

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US9308307B2 (en) 2007-09-13 2016-04-12 Fresenius Medical Care Holdings, Inc. Manifold diaphragms
US9517296B2 (en) 2007-09-13 2016-12-13 Fresenius Medical Care Holdings, Inc. Portable dialysis machine
US8597505B2 (en) 2007-09-13 2013-12-03 Fresenius Medical Care Holdings, Inc. Portable dialysis machine
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US8771511B2 (en) 2007-11-29 2014-07-08 Fresenius Medical Care Holdings, Inc. Disposable apparatus and kit for conducting dialysis
US9415152B2 (en) 2007-11-29 2016-08-16 Fresenius Medical Care Holdings, Inc. Disposable apparatus and kit for conducting dialysis
US9199022B2 (en) 2008-09-12 2015-12-01 Fresenius Medical Care Holdings, Inc. Modular reservoir assembly for a hemodialysis and hemofiltration system
US9759710B2 (en) 2008-09-12 2017-09-12 Fresenius Medical Care Holdings, Inc. Modular reservoir assembly for a hemodialysis and hemofiltration system
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US9157786B2 (en) 2012-12-24 2015-10-13 Fresenius Medical Care Holdings, Inc. Load suspension and weighing system for a dialysis machine reservoir
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US7901579B2 (en) 2011-03-08 grant
US20060091057A1 (en) 2006-05-04 application
US20060091056A1 (en) 2006-05-04 application
US20060091058A1 (en) 2006-05-04 application
US20090229466A1 (en) 2009-09-17 application
WO2006049822A1 (en) 2006-05-11 application
US20100096311A1 (en) 2010-04-22 application

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