US20110106117A1 - Device and Method for Modifying the Shape of a Body Organ - Google Patents

Device and Method for Modifying the Shape of a Body Organ Download PDF

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Publication number
US20110106117A1
US20110106117A1 US13/004,239 US201113004239A US2011106117A1 US 20110106117 A1 US20110106117 A1 US 20110106117A1 US 201113004239 A US201113004239 A US 201113004239A US 2011106117 A1 US2011106117 A1 US 2011106117A1
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United States
Prior art keywords
device
lumen
focal deflector
connector
focal
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Abandoned
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US13/004,239
Inventor
Mark L. Mathis
David Reuter
Lucas Gordon
Cruz Beeson
Garrett Beget
Frederick Stewart
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Cardiac Dimensions Inc
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Cardiac Dimensions Inc
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Priority to US47669303P priority Critical
Priority to US10/840,188 priority patent/US7887582B2/en
Application filed by Cardiac Dimensions Inc filed Critical Cardiac Dimensions Inc
Priority to US13/004,239 priority patent/US20110106117A1/en
Assigned to CARDIAC DIMENSIONS, INC. reassignment CARDIAC DIMENSIONS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BEESON, CRUZ, STEWART, FREDERICK, REUTER, DAVID, BEGET, GARRETT, GORDON, LUCAS, MATHIS, MARK
Publication of US20110106117A1 publication Critical patent/US20110106117A1/en
Application status is Abandoned legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2451Inserts in the coronary sinus for correcting the valve shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238Type of minimally invasive operation
    • A61B2017/00243Type of minimally invasive operation cardiac

Abstract

A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.

Description

    CROSS-REFERENCE
  • This application is a divisional of U.S. application Ser. No. 10/840,188, filed May 5, 2004, which application claims the benefit of U.S. Provisional Application No. 60/476,693, filed Jun. 5, 2003; both of which are incorporated herein by reference.
  • BACKGROUND OF THE INVENTION
  • The mitral valve is a portion of the heart that is located between the chambers of the left atrium and the left ventricle. When the left ventricle contracts to pump blood throughout the body, the mitral valve closes to prevent the blood from being pumped back into the left atrium. In some patients, whether due to genetic malformation, disease or injury, the mitral valve fails to close properly causing a condition known as regurgitation, whereby blood is pumped into the atrium upon each contraction of the heart muscle. Regurgitation is a serious, often rapidly deteriorating, condition that reduces circulatory efficiency and must be corrected.
  • Two of the more common techniques for restoring the function of a damaged mitral valve are to surgically repair the valve, replace the valve with a mechanical valve, or to suture a flexible ring around the valve to support it. Each of these procedures is highly invasive because access to the heart is obtained through an opening in the patient's chest. Patients with mitral valve regurgitation are often relatively frail thereby increasing the risks associated with such an operation.
  • One less invasive approach for aiding the closure of the mitral valve involves the placement of a support structure in the cardiac sinus and vessel that passes adjacent the mitral valve. The support structure is designed to push the vessel and surrounding tissue against the valve to aid its closure. This technique has the advantage over other methods of mitral valve repair because it can be performed percutaneously without opening the chest wall. Examples of such devices are shown in U.S. patent application Ser. No. 10/003,910, “Focused Compression Mitral Valve Device and Method;” U.S. patent application Ser. No. 10/142,637, “Body Lumen Device Anchor, Device and Assembly;” U.S. patent application Ser. No. 10/331,143, “System and Method to Effect the Mitral Valve Annulus of a Heart;” and U.S. patent application Ser. No. 10/429,172, “Device and Method for Modifying the Shape of a Body Organ,” filed May 2, 2003. The disclosures of these patent applications are incorporated herein by reference.
  • The purpose of a support device in a lumen such as a vein or artery is to reshape a particular tissue area adjacent to the lumen. In order to be minimally invasive, the reshaping should be limited to the target tissue, such as the mitral valve annulus, and any reshaping of other tissue adjacent to the lumen should be minimized or avoided. For example, to treat mitral valve regurgitation, the device is placed in the coronary sinus to reshape the mitral valve annulus. Care should be taken to minimize the reshaping of other adjacent tissue, such as nearby arteries. See, e.g., the following applications (the disclosures of which are incorporated herein by reference): U.S. patent application Ser. No. 09/855,945, “Mitral Valve Therapy Device, System and Method” (published Nov. 14, 2002, as U.S. 2002/0169504 A1); U.S. patent application Ser. No. 09/855,946, “Mitral Valve Therapy Assembly and Method” (published Nov. 14, 2002, as U.S. 2002/0169502 A1). It is also advisable to monitor cardiac perfusion during and after such mitral valve regurgitation therapy. See, e.g., U.S. patent application Ser. No. 10/366,585, “Method of Implanting a Mitral Valve Therapy Device,” the disclosure of which is incorporated herein by reference.
  • SUMMARY OF THE INVENTION
  • One aspect of the invention is a tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The focal deflector may have an expandable portion that is, e.g., self-expanding or expandable through the application of an actuation force. The device may also have a lock to lock the focal deflector in an expanded configuration.
  • In some embodiments the focal deflector is integral with the connector. For example, the focal deflector may be a bend in the connector, such as a bend that extends away from the lumen axis and toward the target tissue. The focal deflector may include a local change to the linear shape of the connector, such as a portion of increased curve of the curved line of the connector. The focal deflector may also include a flattened portion of the connector.
  • In some embodiments the focal deflector includes an expandable anchor and possibly a portion integral with the connector and adapted to extend away from the lumen axis and toward the target tissue when the device is deployed in the lumen.
  • Another aspect of the invention is a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen. In some embodiments the expanding step includes the steps of expanding the distal anchor to anchor within the lumen; applying a proximally directed force on the device; and expanding the proximal anchor while applying the proximally directed force.
  • In some embodiments, the placing step includes the step of orienting the focal deflector away from the lumen axis and toward the target tissue. In other embodiments, the placing step includes the step of orienting the focal deflector away from the lumen axis and away from the target tissue.
  • The applying step may include the step of expanding the focal deflector, such as by applying an actuation force to the focal deflector. The focal deflector may also be locked in its expanded configuration. In some embodiments the applying and expanding steps may include expanding the distal anchor to anchor within the lumen; applying a proximally directed force on the device; expanding the focal deflector while applying the proximally directed force; applying a proximally directed force on the device after expanding the focal deflector; and expanding the proximal anchor while applying the proximally directed force of the previous step.
  • Yet another aspect of the invention is a tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In some embodiments the device includes an expandable anchor; a focal deflector; a connector disposed between the anchor and the focal deflector; and a tail extending from the focal deflector away from the anchor. The focal deflector may include an expandable portion. In some embodiments, the focal deflector is adapted to extend away from the lumen axis and away from the target tissue when the device is deployed in the lumen.
  • One application for the device of this invention is in the treatment of mitral valve regurgitation. The invention will be described in further detail below with reference to the drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 shows a tissue reshaping device according to one aspect of the invention deployed in a coronary sinus to reshape the mitral valve annulus to treat mitral valve regurgitation.
  • FIG. 2 is a perspective view of the device shown in FIG. 1.
  • FIG. 3 shows another embodiment of the invention.
  • FIG. 4 shows another embodiment of the invention and its use to treat mitral valve regurgitation.
  • FIG. 5 is a perspective view of the device shown in FIG. 4.
  • FIG. 6 shows an embodiment in which the focal deflector faces in the same direction as the anchors.
  • FIG. 7 shows yet another embodiment of the invention deployed in a coronary sinus to reshape the mitral valve annulus to treat mitral valve regurgitation.
  • FIG. 8 is a perspective view of the device shown in FIG. 7.
  • FIG. 9 shows yet another embodiment of the invention.
  • FIG. 10 shows still another embodiment of the invention.
  • FIG. 11 shows the focal deflector of the embodiment of FIG. 10.
  • FIG. 12 is yet another view of the focal deflector of the embodiment of FIG. 10.
  • FIG. 13 shows yet another embodiment of the invention.
  • FIG. 14 shows an embodiment of the invention with a tail portion extending from the focal deflector.
  • FIG. 15 illustrates one method for delivering an intravascular support to a desired location in the body.
  • DETAILED DESCRIPTION OF THE INVENTION
  • Tissue shaping devices that apply force to a localized, discrete portion of the vessel wall surrounding a lumen have been described. See, e.g., U.S. patent application Ser. No. 10/003,910, “Focused Compression Mitral Valve Device and Method,” which describes the use of such devices disposed in the coronary sinus to treat mitral valve regurgitation. Other therapies deploy one or more rigid devices in the lumen to change the shape of the lumen and adjacent tissue. See, e.g., Lashinski et al. U.S. patent application Ser. No. 10/066,302 (published as U.S. 2002/0151961 A1); Taylor et al. U.S. patent application Ser. No. 10/068,264 (published as U.S. 2002/0183835 A1); Liddicoat et al. U.S. patent application Ser. No. 10/112,354 (published as U.S. 2002/0183838 A1); the disclosures of which are incorporated herein by reference. Still other tissue shaping devices utilize an “anchor and cinch” method to modify tissue adjacent a lumen, i.e., by anchoring a distal anchor, placing a proximally-directed force on a connector extending proximally from the distal anchor, and anchoring a proximal anchor before ceasing the proximally directed force to maintain the device's configuration and the reshaping of the tissue.
  • The present invention provides a device disposed in a lumen to reshape tissue adjacent to the lumen that includes a focal deflector tissue reshaper, two anchors and an optional connector to help maintain the position of the focal tissue reshaper within the lumen. The use of a focal deflector tissue reshaper aimed at target tissue adjacent to the lumen minimizes the risk of adverse consequences from altering the shape of non-target tissue adjacent to other parts of the lumen. The anchors and/or connector may also be used to help reshape the target tissue.
  • FIGS. 1 and 2 show a tissue reshaping device 10 according to one aspect of this invention. Device 10 is designed to be disposed in the coronary sinus or other cardiac vein to treat mitral valve regurgitation. It should be understood that such devices may also be used in other body lumens to reshape other tissue.
  • As shown in FIGS. 1 and 2, device 10 has a proximal anchor 12 and a distal anchor 14 connected by a connector 15. In the embodiment shown in FIGS. 1 and 2, the anchors 12 and 14 are formed from metal wire, preferably made from a shape memory material such as nitinol, bent into a FIG. 8 configuration. Crimps 16 and 18 hold the wire in place and attach the anchors to connector 15. In the embodiment shown in FIG. 1, crimps 16 and 18 are formed from wound wire, such as nitinol. In the embodiment shown in FIG. 2, crimps 16 and 18 are formed from metal tubes, such as titanium tubes.
  • Device 10 is delivered via a catheter to the treatment site within the lumen in a collapsed or unexpanded configuration. After expelling device 10 from the catheter at the treatment site (either by advancing the device distally out of the end of the catheter or by moving the end of the catheter proximally while maintaining the device stationary), the device's anchors begin to self-expand. At the proximal end of each anchor is an eyelet 20 and 22. Advancing eyelets 20 and 22 distally over corresponding lock bumps 24 and 26 further expands and locks the anchors 12 and 14 in an expanded configuration. Further details of the construction, delivery and deployment of such anchors may be found in U.S. patent application Ser. No. 10/142,637, “Body Lumen Device Anchor, Device and Assembly;” U.S. patent application Ser. No. 10/331,143, “System and Method to Effect the Mitral Valve Annulus of a Heart;” and U.S. patent application Ser. No. 10/429,172, “Device and Method for Modifying the Shape of a Body Organ,” filed May 2, 2003. It should be understood that other anchor designs could be used without departing from the invention.
  • Device 10 has a focal deflector 28 facing away from the anchors 12 and 14 and toward the mitral valve annulus. In this embodiment, focal deflector 28 is formed as a bend in the connector 15. As shown in FIG. 1, when disposed in lumen 30 (shown here as the coronary sinus), the orientation of device 10 places focal deflector 28 against the target tissue 37 to reshape the mitral valve annulus 38. Device 10 may be curved to help ensure this orientation. For delivery via a catheter, focal deflector 28 is deformed and assumes the shape shown in FIGS. 1 and 2 after deployment from the catheter.
  • Because of the action of focal deflector 28, the desired reshaping of the mitral valve annulus may be achieved with less cinching than other device designs or even with no cinching. Thus, the anchors do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors. In addition, with less or no cinching, any undesirable effect on non-target tissue adjacent the connector is also minimized. On the other hand, should reshaping adjacent to the anchors and/or connector be desired, such reshaping can be achieved through a combination of expansion of the anchors and cinching of the connector between them. The cinching is performed as with prior devices: by anchoring a distal anchor, placing a proximally-directed force on a connector extending proximally from the distal anchor, and anchoring a proximal anchor before ceasing the proximally directed force to maintain the device's configuration and the reshaping of the tissue.
  • FIG. 3 shows another embodiment of the invention. As in the embodiment of FIGS. 1 and 2, device 40 in FIG. 3 has two anchors 42 and 44 connected by a connector 46. Connector 46 is formed as a ribbon, preferably from a shape memory material such as nitinol, with a focal deflector 48 formed therein. The anchors 42 and 44 may be formed like the anchors of the previous embodiment.
  • In use, device 40 is delivered via catheter to the treatment site in a collapsed or unexpanded configuration. Device 40 is then deployed by expelling it from the catheter and expanding it within a lumen in a position and orientation that places focal deflector 48 against the lumen's vessel wall adjacent to the target tissue to modify the shape of the target tissue. While the device may also be cinched to provide additional reshaping, the amount of cinching required will be less, thereby minimizing the reshaping of any non-target tissue adjacent the lumen by the connector. In addition, as with the previous embodiment, anchors 42 and 44 do not need to be expanded as much, thereby minimizing the reshaping of the non-target tissue adjacent to the anchors.
  • FIGS. 4 and 5 show yet another embodiment of the invention and its use to treat mitral valve regurgitation. Device 50 has proximal and distal anchors 52 and 54 connected by a connector 56. Anchors 52 and 54 are preferably formed like the anchors of the embodiments of FIGS. 1-3.
  • A focal deflector 58 is disposed on connector 56. In this embodiment, focal deflector 58 has substantially the same design as anchors 52 and 54. Focal deflector 58 is formed from wire (preferably made from a shape memory material such as nitinol) and has a FIG. 8 configuration when expanded. A crimp 62 attaches the wire to the connector 56. The anchors and focal deflector are delivered via a catheter to the appropriate site within the lumen in an unexpanded configuration, then expanded to a deployed configuration through the application of actuation forces delivered by catheters or other known tools. Like the anchors, focal deflector 58 may be locked in its expanded configuration by advancing an eyelet 60 over a lock bump 61.
  • As shown in FIG. 4, when disposed in a lumen such as the coronary sinus, the orientation of device 50 places focal deflector 58 against the coronary sinus wall adjacent the target tissue 59 of the mitral valve annulus 57 to reshape the mitral valve annulus. Device 50 may be curved to help ensure proper orientation. As with the other embodiments, because of the action of focal deflector 58, the desired reshaping of the mitral valve annulus may be achieved with less or even with no cinching. Thus, the anchors do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors. In addition, with less or no cinching, the effect on non-target tissue adjacent the connector is also minimized.
  • Because it can be expanded and locked like an anchor, the focal deflector 58 of FIGS. 4 and 5 can also be used like an anchor during a cinching operation. For example, after expanding and locking distal anchor 54, a proximally-directed force can be exerted on the portion of connector 56 extending between distal anchor 54 and focal deflector 58 prior to expanding and locking focal deflector 58 to cinch the distal portion of device 50. Likewise, after expanding and locking focal deflector 58, another proximally-directed force can be exerted on the portion of connector 56 extending between focal deflector 58 and proximal anchor 52 prior to expanding and locking proximal anchor 52 to cinch the proximal portion of device 50. If cinching is needed to achieve the desired shape modification of the target tissue, the presence of focal deflector 58 enables a user to cinch the distal and proximal portions of device 50 with different cinching forces.
  • The focal deflector shown in the embodiment of FIGS. 4 and 5 may have other orientations. For example, FIG. 6 shows an embodiment in which the focal deflector 68 of device 60 faces in the same direction as the anchors 62 and 64. In addition, the focal deflector of the embodiments of FIGS. 4-6 may be self-expanding but not locking.
  • FIGS. 7 and 8 show yet another embodiment of the invention. Like the other embodiments, device 70 has a proximal anchor 72 and a distal anchor 74 connected by a connector 76. Disposed on connector 76 is a focal deflector 78 formed as an expanded cut-out tube, such as a modified stent.
  • As shown in FIG. 7, device 70 may be deployed in the coronary sinus to treat mitral valve regurgitation by reshaping the tissue adjacent to focal deflector 78. Device 70 is delivered to in an expanded configuration to the treatment site, then expelled from the catheter. Anchors 72 and 74 self-expand, then are further expanded and locked as in the other embodiments. Focal deflector 78 may also self-expand to the configuration shown in FIGS. 7 and 8. Alternatively, focal deflector 78 may be expanded by using a balloon catheter to provide the actuation force, as is well-known in the stent art.
  • As in the other embodiments, because of the action of focal deflector 78, the desired reshaping of the mitral valve annulus may be achieved with less or even with no cinching. Thus, the anchors do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors. In addition, with less or no cinching, the effect on non-target tissue adjacent the connector is also minimized.
  • FIG. 9 shows an embodiment of a device 80 with proximal and distal anchors 82 and 84 with a FIG. 8 design like other embodiments connected by a connector 86. A focal deflector 88 is formed as a flattened area in connector 86. In this embodiment, connector 86 and focal deflector 88 are formed from shape memory material wire, such as nitinol. While FIG. 9 shows connector 86 and focal deflector 88 as three discrete straight segments, any or all of these elements may be have a curve. In any variation on the embodiment of FIG. 9, however, the focal deflector 88 is straighter than the connector portions extending distally and proximally from it to the distal and proximal anchors, respectively. Device 80 may be delivered and deployed at the treatment site in the same manner as the embodiments described above.
  • FIGS. 10-12 show yet another embodiment of a device 90 with proximal and distal anchors 92 and 94 with a FIG. 8 design like other embodiments connected by a connector 96. A focal deflector 98 is also formed with a wire 100 (preferably made from a shape memory material such as nitinol) bent into a FIG. 8 pattern. As shown in more detail in FIGS. 11 and 12, instead of a wrapped wire or solid metal crimp, focal deflector 98 has a base 102 with two downwardly extending struts 104. The angular spread between struts 104 helps orient the device within the lumen. Base 102 may be made from a laser-cut shape memory material such as nitinol. The combination of the expansion of anchor wire 100 (as in the embodiment shown in FIG. 6) with the downward pressure from struts 104 (as in the embodiments shown in FIGS. 1-3) provide for focal deflection of target tissue adjacent to the focal deflector.
  • As with other embodiments, device 90 may be delivered via a catheter and deployed in the coronary sinus to treat mitral valve regurgitation by reshaping the tissue adjacent to focal deflector 98. The device is in a deformed and unexpanded state within the catheter, and self-expands and reforms into the shape shown in FIG. 10 once expelled from the catheter. The anchors 92 and 94 and the anchor portion 100 of focal deflector 98 are further expanded and locked by advancing their respective eyelets over corresponding lock bumps on their proximal sides.
  • Because of the action of focal deflector 98, the desired reshaping of the mitral valve annulus may be achieved with less or even with no cinching. Thus, the anchors 92 and 94 do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors. In addition, with less or no cinching, the effect on non-target tissue adjacent the connector is also minimized. Furthermore, because focal deflector 98 is formed similar to an anchor, the presence of focal deflector 98 enables a user to cinch the distal and proximal portions of device 90 with different cinching forces.
  • The embodiment of FIG. 13 omits the wire 100 of focal deflector 98 but is identical to the embodiment of FIGS. 10-12 in all other respects.
  • FIG. 14 shows an embodiment of a device 110 with a proximal anchor 112 formed in a FIG. 8 pattern, as in other embodiments. A focal deflector 114 formed as an anchor in a FIG. 8 pattern, as in the embodiment of FIG. 6, is connected to proximal anchor 112 by a connector 116. A tail 118 extends distally from focal deflector 114 formed from a wire bent in a loop. The loop has a circumference that allows the loop to engage the wall of the vessel in which the device is placed. The points of engagement between the loop and vessel depend on the relative diameters of the loop and vessel. When deployed in a curved vessel, such as the coronary sinus, the loop will follow the vessel's curve to orient the device correctly within the vessel. The ends of the wire are contained with a crimp 120. A small loop 122 is formed at the distal end of tail 118 to provide additional spring action to the tail.
  • As in the other embodiments, device 110 may be delivered via a catheter and deployed in the coronary sinus to treat mitral valve regurgitation by reshaping the tissue adjacent to focal deflector 114. The device is in a deformed and unexpanded state within the catheter, and self-expands and reforms into the shape shown in FIG. 14 once expelled from the catheter. The proximal anchor 112 and focal deflector 114 are further expanded and locked by advancing their respective eyelets over corresponding lock bumps on their proximal sides.
  • Element 114 of device 110 in FIG. 14 may be used as a distal anchor instead of as a focal deflector, of course.
  • FIG. 15 illustrates one method for delivering an intravascular support 150 in accordance with the present invention to a desired location in the body. As indicated above, intravascular support 150 is preferably loaded into and routed to a desired location within a catheter 200 with the proximal and distal anchors in a collapsed or deformed condition. That is, the eyelet 172 of the distal anchor 170 is positioned proximally of the distal lock 160 and the eyelet 142 of the proximal anchor is positioned proximal to the proximal lock 164. The physician ejects the distal end of the intravascular support from the catheter 200 into the lumen by advancing the intravascular support or retracting the catheter or a combination thereof. A pusher (not shown) provides distal movement of the intravascular support with respect to catheter 200, and a tether provides proximal movement of the intravascular support with respect to catheter 200. Because of the inherent recoverability of the material from which it is formed, the distal anchor begins to expand as soon as it is outside the catheter. Once the intravascular support is properly positioned, the eyelet 172 of the distal anchor is pushed distally over the distal lock 160 so that the distal anchor 170 further expands and locks in place to securely engage the lumen wall and remains in the expanded condition. Next, the proximal end of the support wire is tensioned by applying a proximally-directed force on the support wire and distal anchor to apply sufficient pressure on the tissue adjacent the support wire to modify the shape of that tissue. In the case of the mitral valve, fluoroscopy, ultrasound or other imaging technology may be used to see when the support wire supplies sufficient pressure on the mitral valve to aid in its complete closure with each ventricular contraction without otherwise adversely affecting the patient. Once the proper pressure of the support wire has been determined, the proximal anchor is deployed from the catheter and allowed to begin its expansion. The eyelet 142 of the proximal anchor is advanced distally over the proximal lock 164 to expand and lock the proximal anchor, thereby securely engaging the lumen wall and maintaining the pressure of the support wire against the lumen wall. Finally, the mechanism for securing the proximal end of the intravascular support can be released. In one embodiment, the securement is made with a braided loop 202 at the end of the tether and a hitch pin 204. The hitch pin 204 is withdrawn thereby releasing the loop 202 so it can be pulled through the proximal lock 164 at the proximal end of the intravascular support 150.
  • Other modifications of the device are within the scope of the invention. For example, the anchors may be of some other design known in the art. In addition, the focal deflector may have some other shape designed to make the desired change in the target tissue.

Claims (19)

1. A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen, the device comprising:
first and second anchors;
a connector disposed between the first and second anchors; and
a focal deflector disposed between the first and second anchors.
2. The device of claim 1 wherein the lumen has a lumen axis, the focal deflector being adapted to extend away from the lumen axis and toward the target tissue when the device is deployed in the lumen.
3. The device of claim 1 wherein the lumen has a lumen axis, the focal deflector being adapted to extend away from the lumen axis and away from the target tissue when the device is deployed in the lumen.
4. The device of claim 1 wherein the focal deflector comprises an expandable portion.
5. The device of claim 4 wherein the expandable portion is adapted to be self-expanding.
6. The device of claim 4 wherein the expandable portion is adapted to be expanded by an actuation force.
7. The device of claim 4 further comprising a lock locking the focal deflector in an expanded configuration.
8. The device of claim 1 further comprising an attachment element attaching the focal deflector to the connector.
9. The device of claim 1 wherein the focal deflector is integral with the connector.
10. The device of claim 9 wherein the focal deflector comprises a bend in the connector.
11. The device of claim 10 wherein the lumen has a lumen axis, the focal deflector being adapted to extend away from the lumen axis and toward the target tissue when the device is deployed in the lumen.
12. The device of claim 9 wherein the connector has a linear shape, the focal deflector comprising a local change to the linear shape.
13. The device of claim 12 wherein the connector linear shape is a curved line, the focal deflector comprising a portion of increased curve of the curved line.
14. The device of claim 9 wherein the focal deflector comprises a flattened portion of the connector.
15. The device of claim 1 wherein the focal deflector comprises an expandable anchor.
16. The device of claim 15 wherein the lumen has a lumen axis, the focal deflector further comprising a portion integral with the connector and adapted to extend away from the lumen axis and toward the target tissue when the device is deployed in the lumen.
17. A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen, the device comprising:
an expandable anchor;
a focal deflector;
a connector disposed between the anchor and the focal deflector; and
a tail extending from the focal deflector away from the anchor.
18. The tissue shaping device of claim 17 wherein the focal deflector comprises an expandable portion.
19. The device of claim 17 wherein the lumen has a lumen axis, the focal deflector being adapted to extend away from the lumen axis and away from the target tissue when the device is deployed in the lumen.
US13/004,239 2003-06-05 2011-01-11 Device and Method for Modifying the Shape of a Body Organ Abandoned US20110106117A1 (en)

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US47669303P true 2003-06-05 2003-06-05
US10/840,188 US7887582B2 (en) 2003-06-05 2004-05-05 Device and method for modifying the shape of a body organ
US13/004,239 US20110106117A1 (en) 2003-06-05 2011-01-11 Device and Method for Modifying the Shape of a Body Organ

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US13/004,239 US20110106117A1 (en) 2003-06-05 2011-01-11 Device and Method for Modifying the Shape of a Body Organ

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050187619A1 (en) * 2002-05-08 2005-08-25 Mathis Mark L. Body lumen device anchor, device and assembly
US20060276891A1 (en) * 2003-12-19 2006-12-07 Gregory Nieminen Mitral Valve Annuloplasty Device with Twisted Anchor
US20080015407A1 (en) * 2003-05-02 2008-01-17 Mathis Mark L Device and Method for Modifying the Shape of a Body Organ
US8172898B2 (en) 2001-12-05 2012-05-08 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US8250960B2 (en) 2008-08-11 2012-08-28 Cardiac Dimensions, Inc. Catheter cutting tool
US9320600B2 (en) 2002-01-30 2016-04-26 Cardiac Dimensions Pty. Ltd. Tissue shaping device
CN107252327A (en) * 2016-10-21 2017-10-17 塞佩赫·法里亚比 Tissue connection device for percutaneous treatment for mitral regurgitation

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406420B1 (en) * 1997-01-02 2002-06-18 Myocor, Inc. Methods and devices for improving cardiac function in hearts
US6332893B1 (en) * 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US7011682B2 (en) * 2000-01-31 2006-03-14 Edwards Lifesciences Ag Methods and apparatus for remodeling an extravascular tissue structure
US7510576B2 (en) * 2001-01-30 2009-03-31 Edwards Lifesciences Ag Transluminal mitral annuloplasty
US6537198B1 (en) * 2000-03-21 2003-03-25 Myocor, Inc. Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly
US6616684B1 (en) * 2000-10-06 2003-09-09 Myocor, Inc. Endovascular splinting devices and methods
US6723038B1 (en) * 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6800090B2 (en) * 2001-05-14 2004-10-05 Cardiac Dimensions, Inc. Mitral valve therapy device, system and method
US7635387B2 (en) * 2001-11-01 2009-12-22 Cardiac Dimensions, Inc. Adjustable height focal tissue deflector
US6908478B2 (en) * 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
US6764510B2 (en) * 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US20050209690A1 (en) * 2002-01-30 2005-09-22 Mathis Mark L Body lumen shaping device with cardiac leads
JP4926980B2 (en) * 2005-01-20 2012-05-09 カーディアック ディメンションズ インコーポレイテッド Organization shaping device
US7311729B2 (en) * 2002-01-30 2007-12-25 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6797001B2 (en) * 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
AT417573T (en) * 2002-05-08 2009-01-15 Cardiac Dimensions Inc Means for changing the shape of a mitral valve
US20030233022A1 (en) * 2002-06-12 2003-12-18 Vidlund Robert M. Devices and methods for heart valve treatment
US7112219B2 (en) * 2002-11-12 2006-09-26 Myocor, Inc. Devices and methods for heart valve treatment
US7316708B2 (en) * 2002-12-05 2008-01-08 Cardiac Dimensions, Inc. Medical device delivery system
US7837729B2 (en) 2002-12-05 2010-11-23 Cardiac Dimensions, Inc. Percutaneous mitral valve annuloplasty delivery system
US7314485B2 (en) * 2003-02-03 2008-01-01 Cardiac Dimensions, Inc. Mitral valve device using conditioned shape memory alloy
US20040158321A1 (en) * 2003-02-12 2004-08-12 Cardiac Dimensions, Inc. Method of implanting a mitral valve therapy device
US20040254600A1 (en) * 2003-02-26 2004-12-16 David Zarbatany Methods and devices for endovascular mitral valve correction from the left coronary sinus
US20040220657A1 (en) * 2003-05-02 2004-11-04 Cardiac Dimensions, Inc., A Washington Corporation Tissue shaping device with conformable anchors
US20060161169A1 (en) * 2003-05-02 2006-07-20 Cardiac Dimensions, Inc., A Delaware Corporation Device and method for modifying the shape of a body organ
US7351259B2 (en) * 2003-06-05 2008-04-01 Cardiac Dimensions, Inc. Device, system and method to affect the mitral valve annulus of a heart
CA2533020A1 (en) 2003-07-18 2005-03-03 Ev3 Santa Rosa, Inc. Remotely activated mitral annuloplasty system and methods
US7004176B2 (en) * 2003-10-17 2006-02-28 Edwards Lifesciences Ag Heart valve leaflet locator
US20050137449A1 (en) * 2003-12-19 2005-06-23 Cardiac Dimensions, Inc. Tissue shaping device with self-expanding anchors
US7837728B2 (en) * 2003-12-19 2010-11-23 Cardiac Dimensions, Inc. Reduced length tissue shaping device
US7794496B2 (en) * 2003-12-19 2010-09-14 Cardiac Dimensions, Inc. Tissue shaping device with integral connector and crimp
US20050137450A1 (en) * 2003-12-19 2005-06-23 Cardiac Dimensions, Inc., A Washington Corporation Tapered connector for tissue shaping device
US7993397B2 (en) * 2004-04-05 2011-08-09 Edwards Lifesciences Ag Remotely adjustable coronary sinus implant
US7211110B2 (en) * 2004-12-09 2007-05-01 Edwards Lifesciences Corporation Diagnostic kit to assist with heart valve annulus adjustment
US20060247491A1 (en) * 2005-04-27 2006-11-02 Vidlund Robert M Devices and methods for heart valve treatment
US7503932B2 (en) * 2006-04-11 2009-03-17 Cardiac Dimensions, Inc. Mitral valve annuloplasty device with vena cava anchor
US7854849B2 (en) * 2006-10-10 2010-12-21 Multiphase Systems Integration Compact multiphase inline bulk water separation method and system for hydrocarbon production
SE535690C2 (en) 2010-03-25 2012-11-13 Jan Otto Solem An implantable device and kit for cardiac support, comprising means for generating longitudinal movement of the mitral
GB201100137D0 (en) 2011-01-06 2011-02-23 Davies Helen C S Apparatus and method of assessing a narrowing in a fluid tube
US9339348B2 (en) 2011-08-20 2016-05-17 Imperial Colege of Science, Technology and Medicine Devices, systems, and methods for assessing a vessel
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
CN107530166A (en) 2015-02-13 2018-01-02 魅尔皮德股份有限公司 Valve replacement using rotational anchors

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5617854A (en) * 1994-06-22 1997-04-08 Munsif; Anand Shaped catheter device and method
US6045497A (en) * 1997-01-02 2000-04-04 Myocor, Inc. Heart wall tension reduction apparatus and method
US6162168A (en) * 1997-01-02 2000-12-19 Myocor, Inc. Heart wall tension reduction apparatus
US6478776B1 (en) * 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US6556873B1 (en) * 1999-11-29 2003-04-29 Medtronic, Inc. Medical electrical lead having variable bending stiffness
US6562066B1 (en) * 2001-03-02 2003-05-13 Eric C. Martin Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium
US7087064B1 (en) * 2002-10-15 2006-08-08 Advanced Cardiovascular Systems, Inc. Apparatuses and methods for heart valve repair
US20080071364A1 (en) * 2004-03-15 2008-03-20 Baker Medical Research Institute Treating Valve Failure
US7955384B2 (en) * 2003-11-12 2011-06-07 Medtronic Vascular, Inc. Coronary sinus approach for repair of mitral valve regurgitation
US20120197389A1 (en) * 2001-12-05 2012-08-02 Alferness Clifton A Device and Method for Modifying the Shape of a Body Organ

Family Cites Families (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3974526A (en) 1973-07-06 1976-08-17 Dardik Irving I Vascular prostheses and process for producing the same
US3995623A (en) 1974-12-23 1976-12-07 American Hospital Supply Corporation Multipurpose flow-directed catheter
FR2306671B1 (en) 1975-04-11 1977-11-10 Rhone Poulenc Ind
US4164046A (en) 1977-05-16 1979-08-14 Cooley Denton Valve prosthesis
US4588395A (en) * 1978-03-10 1986-05-13 Lemelson Jerome H Catheter and method
US4485816A (en) 1981-06-25 1984-12-04 Alchemia Shape-memory surgical staple apparatus and method for use in surgical suturing
US4550870A (en) 1983-10-13 1985-11-05 Alchemia Ltd. Partnership Stapling device
CA1303298C (en) 1986-08-06 1992-06-16 Alain Carpentier Flexible cardiac valvular support prosthesis
US4830023A (en) * 1987-11-27 1989-05-16 Medi-Tech, Incorporated Medical guidewire
US5099838A (en) * 1988-12-15 1992-03-31 Medtronic, Inc. Endocardial defibrillation electrode system
JP2754067B2 (en) 1989-01-17 1998-05-20 日本ゼオン株式会社 Medical body wall hole thromboembolism jig
US5350420A (en) 1989-07-31 1994-09-27 Baxter International Inc. Flexible annuloplasty ring and holder
CA2026604A1 (en) * 1989-10-02 1991-04-03 Rodney G. Wolff Articulated stent
US5454365A (en) 1990-11-05 1995-10-03 Bonutti; Peter M. Mechanically expandable arthroscopic retractors
US5458615A (en) 1993-07-06 1995-10-17 Advanced Cardiovascular Systems, Inc. Stent delivery system
US5261916A (en) 1991-12-12 1993-11-16 Target Therapeutics Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling
US5265601A (en) 1992-05-01 1993-11-30 Medtronic, Inc. Dual chamber cardiac pacing from a single electrode
GB9213978D0 (en) * 1992-07-01 1992-08-12 Skidmore Robert Medical devices
US5250071A (en) 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
US6805128B1 (en) 1996-10-22 2004-10-19 Epicor Medical, Inc. Apparatus and method for ablating tissue
US5452733A (en) 1993-02-22 1995-09-26 Stanford Surgical Technologies, Inc. Methods for performing thoracoscopic coronary artery bypass
US5441515A (en) 1993-04-23 1995-08-15 Advanced Cardiovascular Systems, Inc. Ratcheting stent
WO1994027670A1 (en) * 1993-06-02 1994-12-08 Cardiac Pathways Corporation Catheter having tip with fixation means
FR2706309B1 (en) * 1993-06-17 1995-10-06 Sofamor surgical treatment instrument of an intervertebral disc through an anterior approach.
FR2710254B1 (en) 1993-09-21 1995-10-27 Mai Christian Clip multi-branches autorétentive dynamic compression osteosynthesis.
DE69419877T2 (en) * 1993-11-04 1999-12-16 Bard Inc C R Fixed vascular prosthesis
US5728122A (en) * 1994-01-18 1998-03-17 Datascope Investment Corp. Guide wire with releaseable barb anchor
US5417708A (en) 1994-03-09 1995-05-23 Cook Incorporated Intravascular treatment system and percutaneous release mechanism therefor
US5449373A (en) 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
FR2718035B1 (en) 1994-04-05 1996-08-30 Ela Medical Sa A method for controlling a double atrial pacemaker triple room type programmable fallback mode.
FR2718036B1 (en) * 1994-04-05 1996-08-30 Ela Medical Sa A method for controlling a double atrial triple chamber pacemaker type.
CA2189006A1 (en) 1994-04-29 1995-11-09 David L. Sandock Medical prosthetic stent and method of manufacture
US5433727A (en) 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
US5899882A (en) * 1994-10-27 1999-05-04 Novoste Corporation Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
US5575818A (en) 1995-02-14 1996-11-19 Corvita Corporation Endovascular stent with locking ring
US5554177A (en) 1995-03-27 1996-09-10 Medtronic, Inc. Method and apparatus to optimize pacing based on intensity of acoustic signal
US5693089A (en) 1995-04-12 1997-12-02 Inoue; Kanji Method of collapsing an implantable appliance
DE69626108T2 (en) 1995-04-14 2003-11-20 Boston Scient Ltd The stent delivery device with rolling membrane
US5601600A (en) * 1995-09-08 1997-02-11 Conceptus, Inc. Endoluminal coil delivery system having a mechanical release mechanism
US6053900A (en) * 1996-02-16 2000-04-25 Brown; Joe E. Apparatus and method for delivering diagnostic and therapeutic agents intravascularly
WO1997021402A1 (en) * 1995-12-14 1997-06-19 Prograft Medical, Inc. Stent-graft deployment apparatus and method
US5645560A (en) * 1995-12-15 1997-07-08 Cardiovascular Dynamics, Inc. Fixed focal balloon for interactive angioplasty and stent implantation
US5853422A (en) 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US5827293A (en) * 1996-05-13 1998-10-27 Elliott; James B. Subcutaneous insertion device
US6056775A (en) * 1996-05-31 2000-05-02 Ave Galway Limited Bifurcated endovascular stents and method and apparatus for their placement
CA2258732C (en) * 1996-06-20 2006-04-04 Sulzer Vascutek Ltd. Prosthetic repair of body passages
US6015761A (en) * 1996-06-26 2000-01-18 Applied Materials, Inc. Microwave-activated etching of dielectric layers
US6077295A (en) * 1996-07-15 2000-06-20 Advanced Cardiovascular Systems, Inc. Self-expanding stent delivery system
US5741297A (en) * 1996-08-28 1998-04-21 Simon; Morris Daisy occluder and method for septal defect repair
US5655548A (en) 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US5895391A (en) * 1996-09-27 1999-04-20 Target Therapeutics, Inc. Ball lock joint and introducer for vaso-occlusive member
US5868781A (en) * 1996-10-22 1999-02-09 Scimed Life Systems, Inc. Locking stent
US6395017B1 (en) * 1996-11-15 2002-05-28 C. R. Bard, Inc. Endoprosthesis delivery catheter with sequential stage control
US6254628B1 (en) 1996-12-09 2001-07-03 Micro Therapeutics, Inc. Intracranial stent
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US6352561B1 (en) * 1996-12-23 2002-03-05 W. L. Gore & Associates Implant deployment apparatus
IL119911A (en) * 1996-12-25 2001-03-19 Niti Alloys Tech Ltd Surgical clip
US5961545A (en) 1997-01-17 1999-10-05 Meadox Medicals, Inc. EPTFE graft-stent composite device
US6241757B1 (en) 1997-02-04 2001-06-05 Solco Surgical Instrument Co., Ltd. Stent for expanding body's lumen
US5800393A (en) 1997-03-07 1998-09-01 Sahota; Harvinder Wire perfusion catheter
US6275730B1 (en) 1997-03-14 2001-08-14 Uab Research Foundation Method and apparatus for treating cardiac arrythmia
US5978705A (en) 1997-03-14 1999-11-02 Uab Research Foundation Method and apparatus for treating cardiac arrhythmia using auxiliary pulse
US5836882A (en) 1997-03-17 1998-11-17 Frazin; Leon J. Method and apparatus of localizing an insertion end of a probe within a biotic structure
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
WO1998056435A1 (en) 1997-06-13 1998-12-17 Micro Therapeutics, Inc. Contoured syringe and novel luer hub and methods for embolizing blood vessels
FR2766374B1 (en) 1997-07-24 2000-01-28 Medex Sa Device for injecting a liquid medical use syringe associated with the device and implementation of the syringe METHOD
US6007519A (en) 1997-07-30 1999-12-28 Rosselli; Matteo Central access cannulation device
US5984944A (en) 1997-09-12 1999-11-16 B. Braun Medical, Inc. Introducer for an expandable vascular occlusion device
US6096064A (en) 1997-09-19 2000-08-01 Intermedics Inc. Four chamber pacer for dilated cardiomyopthy
EP1017336B1 (en) 1997-09-24 2007-08-15 Med Institute, Inc. Radially expandable stent
US6086611A (en) 1997-09-25 2000-07-11 Ave Connaught Bifurcated stent
US5928258A (en) 1997-09-26 1999-07-27 Corvita Corporation Method and apparatus for loading a stent or stent-graft into a delivery sheath
US6099552A (en) 1997-11-12 2000-08-08 Boston Scientific Corporation Gastrointestinal copression clips
US6503271B2 (en) 1998-01-09 2003-01-07 Cordis Corporation Intravascular device with improved radiopacity
US6129755A (en) 1998-01-09 2000-10-10 Nitinol Development Corporation Intravascular stent having an improved strut configuration
US6190406B1 (en) * 1998-01-09 2001-02-20 Nitinal Development Corporation Intravascular stent having tapered struts
US6342067B1 (en) * 1998-01-09 2002-01-29 Nitinol Development Corporation Intravascular stent having curved bridges for connecting adjacent hoops
US6345198B1 (en) * 1998-01-23 2002-02-05 Pacesetter, Inc. Implantable stimulation system for providing dual bipolar sensing using an electrode positioned in proximity to the tricuspid valve and programmable polarity
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
DE69931152T2 (en) 1998-03-27 2007-04-05 Cook Urological Inc., Spencer Minimally invasive device for capture of objects in hollow organs
US6200336B1 (en) * 1998-06-02 2001-03-13 Cook Incorporated Multiple-sided intraluminal medical device
US6250308B1 (en) 1998-06-16 2001-06-26 Cardiac Concepts, Inc. Mitral valve annuloplasty ring and method of implanting
NL1009551C2 (en) 1998-07-03 2000-01-07 Cordis Europ Vena cava filter improvements for controlled ejection.
US6228098B1 (en) 1998-07-10 2001-05-08 General Surgical Innovations, Inc. Apparatus and method for surgical fastening
US6358276B1 (en) * 1998-09-30 2002-03-19 Impra, Inc. Fluid containing endoluminal stent
US6458092B1 (en) * 1998-09-30 2002-10-01 C. R. Bard, Inc. Vascular inducing implants
US7044134B2 (en) 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
US6214036B1 (en) 1998-11-09 2001-04-10 Cordis Corporation Stent which is easily recaptured and repositioned within the body
JP4391699B2 (en) 1998-11-20 2009-12-24 株式会社ネクスト Hemostatic agent insertion device
AT465693T (en) 1999-01-27 2010-05-15 Medtronic Inc Device for cardiac valve surgery
US7018401B1 (en) * 1999-02-01 2006-03-28 Board Of Regents, The University Of Texas System Woven intravascular devices and methods for making the same and apparatus for delivery of the same
CA2620783C (en) 1999-04-09 2011-04-05 Evalve, Inc. Methods and apparatus for cardiac valve repair
US6183512B1 (en) * 1999-04-16 2001-02-06 Edwards Lifesciences Corporation Flexible annuloplasty system
US6317615B1 (en) 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US6758830B1 (en) * 1999-05-11 2004-07-06 Atrionix, Inc. Catheter positioning system
US6602289B1 (en) 1999-06-08 2003-08-05 S&A Rings, Llc Annuloplasty rings of particular use in surgery for the mitral valve
US6626899B2 (en) * 1999-06-25 2003-09-30 Nidus Medical, Llc Apparatus and methods for treating tissue
US7192442B2 (en) 1999-06-30 2007-03-20 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
SE514718C2 (en) * 1999-06-29 2001-04-09 Jan Otto Solem Device for treatment of inadequate sealing ability of mitralisklaffapparaten
US6997951B2 (en) * 1999-06-30 2006-02-14 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6391038B2 (en) 1999-07-28 2002-05-21 Cardica, Inc. Anastomosis system and method for controlling a tissue site
US20030078654A1 (en) * 2001-08-14 2003-04-24 Taylor Daniel C. Method and apparatus for improving mitral valve function
FR2799364B1 (en) 1999-10-12 2001-11-23 Jacques Seguin An annuloplasty usable by minimally invasive way
US6613075B1 (en) 1999-10-27 2003-09-02 Cordis Corporation Rapid exchange self-expanding stent delivery catheter system
US6368284B1 (en) 1999-11-16 2002-04-09 Cardiac Intelligence Corporation Automated collection and analysis patient care system and method for diagnosing and monitoring myocardial ischemia and outcomes thereof
CN1806775A (en) 2000-01-14 2006-07-26 维亚科公司 Tissue annuloplasty band and apparatus and method for fashioning, sizing and implanting the same
US6810882B2 (en) 2001-01-30 2004-11-02 Ev3 Santa Rosa, Inc. Transluminal mitral annuloplasty
US7510576B2 (en) * 2001-01-30 2009-03-31 Edwards Lifesciences Ag Transluminal mitral annuloplasty
US6402781B1 (en) * 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
US7011682B2 (en) 2000-01-31 2006-03-14 Edwards Lifesciences Ag Methods and apparatus for remodeling an extravascular tissue structure
CA2433881C (en) 2001-01-30 2009-08-18 Randall T. Lashinski Medical system and method for remodeling an extravascular tissue structure
US6989028B2 (en) 2000-01-31 2006-01-24 Edwards Lifesciences Ag Medical system and method for remodeling an extravascular tissue structure
US6821297B2 (en) 2000-02-02 2004-11-23 Robert V. Snyders Artificial heart valve, implantation instrument and method therefor
US6358195B1 (en) * 2000-03-09 2002-03-19 Neoseed Technology Llc Method and apparatus for loading radioactive seeds into brachytherapy needles
US6569198B1 (en) * 2000-03-31 2003-05-27 Richard A. Wilson Mitral or tricuspid valve annuloplasty prosthetic device
US6442427B1 (en) 2000-04-27 2002-08-27 Medtronic, Inc. Method and system for stimulating a mammalian heart
IL136213D0 (en) 2000-05-17 2001-05-20 Xtent Medical Inc Selectively expandable and releasable stent
US6334864B1 (en) * 2000-05-17 2002-01-01 Aga Medical Corp. Alignment member for delivering a non-symmetric device with a predefined orientation
US6589208B2 (en) 2000-06-20 2003-07-08 Applied Medical Resources Corporation Self-deploying catheter assembly
US6702826B2 (en) * 2000-06-23 2004-03-09 Viacor, Inc. Automated annular plication for mitral valve repair
US6913608B2 (en) 2000-10-23 2005-07-05 Viacor, Inc. Automated annular plication for mitral valve repair
US6769434B2 (en) 2000-06-30 2004-08-03 Viacor, Inc. Method and apparatus for performing a procedure on a cardiac valve
WO2002005888A1 (en) 2000-06-30 2002-01-24 Viacor Incorporated Intravascular filter with debris entrapment mechanism
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US6743219B1 (en) 2000-08-02 2004-06-01 Cordis Corporation Delivery apparatus for a self-expanding stent
AU8714401A (en) 2000-09-07 2002-03-22 Viacor Inc Fixation band for affixing a prosthetic heart valve to tissue
US6602288B1 (en) 2000-10-05 2003-08-05 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template, system and method of use
US6723038B1 (en) * 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US7070618B2 (en) * 2000-10-25 2006-07-04 Viacor, Inc. Mitral shield
AU2027002A (en) 2000-10-27 2002-05-06 Viacor Inc Intracardiovascular access (ICVA<sup>TM</sup>) system
DE10058730A1 (en) * 2000-11-25 2003-01-02 Buehler Motor Gmbh Adjusting for automotive mirrors
WO2002047539A2 (en) 2000-12-15 2002-06-20 Viacor, Inc. Apparatus and method for replacing aortic valve
US7591826B2 (en) 2000-12-28 2009-09-22 Cardiac Dimensions, Inc. Device implantable in the coronary sinus to provide mitral valve therapy
US7052487B2 (en) * 2001-10-26 2006-05-30 Cohn William E Method and apparatus for reducing mitral regurgitation
AU2002243851A1 (en) 2001-02-05 2002-08-19 Viacor, Inc. Apparatus and method for reducing mitral regurgitation
US7125420B2 (en) * 2002-02-05 2006-10-24 Viacor, Inc. Method and apparatus for improving mitral valve function
US6656221B2 (en) 2001-02-05 2003-12-02 Viacor, Inc. Method and apparatus for improving mitral valve function
WO2002076284A2 (en) 2001-03-23 2002-10-03 Viacor, Inc. Method and apparatus for reducing mitral regurgitation
EP1383448B1 (en) 2001-03-29 2008-06-04 Viacor, Inc. Apparatus for improving mitral valve function
US7186264B2 (en) 2001-03-29 2007-03-06 Viacor, Inc. Method and apparatus for improving mitral valve function
US6643546B2 (en) 2001-02-13 2003-11-04 Quetzal Biomedical, Inc. Multi-electrode apparatus and method for treatment of congestive heart failure
CA2441370C (en) 2001-03-05 2011-05-24 Viacor, Incorporated Apparatus and method for reducing mitral regurgitation
US6899734B2 (en) * 2001-03-23 2005-05-31 Howmedica Osteonics Corp. Modular implant for fusing adjacent bone structure
US6733521B2 (en) * 2001-04-11 2004-05-11 Trivascular, Inc. Delivery system and method for endovascular graft
US6619291B2 (en) 2001-04-24 2003-09-16 Edwin J. Hlavka Method and apparatus for catheter-based annuloplasty
US20020188170A1 (en) 2001-04-27 2002-12-12 Santamore William P. Prevention of myocardial infarction induced ventricular expansion and remodeling
US6837901B2 (en) 2001-04-27 2005-01-04 Intek Technology L.L.C. Methods for delivering, repositioning and/or retrieving self-expanding stents
US6800090B2 (en) * 2001-05-14 2004-10-05 Cardiac Dimensions, Inc. Mitral valve therapy device, system and method
US6676702B2 (en) 2001-05-14 2004-01-13 Cardiac Dimensions, Inc. Mitral valve therapy assembly and method
US6599314B2 (en) * 2001-06-08 2003-07-29 Cordis Corporation Apparatus and method for stenting a vessel using balloon-actuated stent with interlocking elements
US6629994B2 (en) 2001-06-11 2003-10-07 Advanced Cardiovascular Systems, Inc. Intravascular stent
US6721598B1 (en) * 2001-08-31 2004-04-13 Pacesetter, Inc. Coronary sinus cardiac lead for stimulating and sensing in the right and left heart and system
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
DK1423066T3 (en) * 2001-09-07 2008-11-17 Mardil Inc A method and apparatus for outer hjertestabilisation
AU2003277116A1 (en) 2002-10-01 2004-04-23 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus
US7144363B2 (en) 2001-10-16 2006-12-05 Extensia Medical, Inc. Systems for heart treatment
AUPR847301A0 (en) * 2001-10-26 2001-11-15 Cook Incorporated Endoluminal prostheses for curved lumens
US7635387B2 (en) * 2001-11-01 2009-12-22 Cardiac Dimensions, Inc. Adjustable height focal tissue deflector
US6949122B2 (en) 2001-11-01 2005-09-27 Cardiac Dimensions, Inc. Focused compression mitral valve device and method
US6908478B2 (en) 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
DE10161543B4 (en) 2001-12-11 2004-02-19 REITAN, Öyvind Implant for the treatment of insufficiency of a heart valve
EP2181668A1 (en) 2001-12-28 2010-05-05 Edwards Lifesciences AG Device for treating mitral annulus dilatation comprising a balloon catheter and a stent
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
SE524709C2 (en) * 2002-01-11 2004-09-21 Edwards Lifesciences Ag Device for delayed remodeling of the cardiovascular and heart valve
US7311729B2 (en) 2002-01-30 2007-12-25 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6960229B2 (en) 2002-01-30 2005-11-01 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
JP4926980B2 (en) 2005-01-20 2012-05-09 カーディアック ディメンションズ インコーポレイテッド Organization shaping device
US20050209690A1 (en) 2002-01-30 2005-09-22 Mathis Mark L Body lumen shaping device with cardiac leads
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
US7004958B2 (en) * 2002-03-06 2006-02-28 Cardiac Dimensions, Inc. Transvenous staples, assembly and method for mitral valve repair
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
AT417573T (en) 2002-05-08 2009-01-15 Cardiac Dimensions Inc Means for changing the shape of a mitral valve
US6824562B2 (en) 2002-05-08 2004-11-30 Cardiac Dimensions, Inc. Body lumen device anchor, device and assembly
US6986775B2 (en) * 2002-06-13 2006-01-17 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US8287555B2 (en) 2003-02-06 2012-10-16 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20040243227A1 (en) 2002-06-13 2004-12-02 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
AT464028T (en) 2002-08-29 2010-04-15 St Jude Medical Cardiology Div Implantable devices for controlling the inner diameter of an aperture in the body
US7112219B2 (en) 2002-11-12 2006-09-26 Myocor, Inc. Devices and methods for heart valve treatment
US7247134B2 (en) 2002-11-12 2007-07-24 Myocor, Inc. Devices and methods for heart valve treatment
US7485143B2 (en) 2002-11-15 2009-02-03 Abbott Cardiovascular Systems Inc. Apparatuses and methods for heart valve repair
US20040098116A1 (en) * 2002-11-15 2004-05-20 Callas Peter L. Valve annulus constriction apparatus and method
US7316708B2 (en) * 2002-12-05 2008-01-08 Cardiac Dimensions, Inc. Medical device delivery system
US7837729B2 (en) * 2002-12-05 2010-11-23 Cardiac Dimensions, Inc. Percutaneous mitral valve annuloplasty delivery system
US6793673B2 (en) 2002-12-26 2004-09-21 Cardiac Dimensions, Inc. System and method to effect mitral valve annulus of a heart
US20040133240A1 (en) 2003-01-07 2004-07-08 Cardiac Dimensions, Inc. Electrotherapy system, device, and method for treatment of cardiac valve dysfunction
US7314485B2 (en) 2003-02-03 2008-01-01 Cardiac Dimensions, Inc. Mitral valve device using conditioned shape memory alloy
US20040158321A1 (en) 2003-02-12 2004-08-12 Cardiac Dimensions, Inc. Method of implanting a mitral valve therapy device
US20040220654A1 (en) * 2003-05-02 2004-11-04 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US20040220657A1 (en) 2003-05-02 2004-11-04 Cardiac Dimensions, Inc., A Washington Corporation Tissue shaping device with conformable anchors
US20060161169A1 (en) 2003-05-02 2006-07-20 Cardiac Dimensions, Inc., A Delaware Corporation Device and method for modifying the shape of a body organ
US7351259B2 (en) * 2003-06-05 2008-04-01 Cardiac Dimensions, Inc. Device, system and method to affect the mitral valve annulus of a heart
CA2533020A1 (en) * 2003-07-18 2005-03-03 Ev3 Santa Rosa, Inc. Remotely activated mitral annuloplasty system and methods
US7794496B2 (en) 2003-12-19 2010-09-14 Cardiac Dimensions, Inc. Tissue shaping device with integral connector and crimp
US7837728B2 (en) 2003-12-19 2010-11-23 Cardiac Dimensions, Inc. Reduced length tissue shaping device
US20060271174A1 (en) 2003-12-19 2006-11-30 Gregory Nieminen Mitral Valve Annuloplasty Device with Wide Anchor
US20050137450A1 (en) 2003-12-19 2005-06-23 Cardiac Dimensions, Inc., A Washington Corporation Tapered connector for tissue shaping device
US20050137449A1 (en) 2003-12-19 2005-06-23 Cardiac Dimensions, Inc. Tissue shaping device with self-expanding anchors
US9526616B2 (en) 2003-12-19 2016-12-27 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5617854A (en) * 1994-06-22 1997-04-08 Munsif; Anand Shaped catheter device and method
US6045497A (en) * 1997-01-02 2000-04-04 Myocor, Inc. Heart wall tension reduction apparatus and method
US6162168A (en) * 1997-01-02 2000-12-19 Myocor, Inc. Heart wall tension reduction apparatus
US6556873B1 (en) * 1999-11-29 2003-04-29 Medtronic, Inc. Medical electrical lead having variable bending stiffness
US6478776B1 (en) * 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US6562066B1 (en) * 2001-03-02 2003-05-13 Eric C. Martin Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium
US20120197389A1 (en) * 2001-12-05 2012-08-02 Alferness Clifton A Device and Method for Modifying the Shape of a Body Organ
US7087064B1 (en) * 2002-10-15 2006-08-08 Advanced Cardiovascular Systems, Inc. Apparatuses and methods for heart valve repair
US7955384B2 (en) * 2003-11-12 2011-06-07 Medtronic Vascular, Inc. Coronary sinus approach for repair of mitral valve regurgitation
US20080071364A1 (en) * 2004-03-15 2008-03-20 Baker Medical Research Institute Treating Valve Failure

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8172898B2 (en) 2001-12-05 2012-05-08 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US9827098B2 (en) 2002-01-30 2017-11-28 Cardiac Dimensions Pty. Ltd. Fixed anchor and pull mitral valve device and method
US10206778B2 (en) 2002-01-30 2019-02-19 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US10052205B2 (en) 2002-01-30 2018-08-21 Cardiac Dimensions Pty. Ltd. Fixed anchor and pull mitral valve device and method
US10327900B2 (en) 2002-01-30 2019-06-25 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9956076B2 (en) 2002-01-30 2018-05-01 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9320600B2 (en) 2002-01-30 2016-04-26 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9827099B2 (en) 2002-01-30 2017-11-28 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9597186B2 (en) 2002-01-30 2017-03-21 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9827100B2 (en) 2002-01-30 2017-11-28 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US8062358B2 (en) 2002-05-08 2011-11-22 Cardiac Dimensions, Inc. Body lumen device anchor, device and assembly
US20050187619A1 (en) * 2002-05-08 2005-08-25 Mathis Mark L. Body lumen device anchor, device and assembly
US20080015407A1 (en) * 2003-05-02 2008-01-17 Mathis Mark L Device and Method for Modifying the Shape of a Body Organ
US9526616B2 (en) 2003-12-19 2016-12-27 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US9956077B2 (en) 2003-12-19 2018-05-01 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US10166102B2 (en) 2003-12-19 2019-01-01 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US20060276891A1 (en) * 2003-12-19 2006-12-07 Gregory Nieminen Mitral Valve Annuloplasty Device with Twisted Anchor
US8250960B2 (en) 2008-08-11 2012-08-28 Cardiac Dimensions, Inc. Catheter cutting tool
CN107252327A (en) * 2016-10-21 2017-10-17 塞佩赫·法里亚比 Tissue connection device for percutaneous treatment for mitral regurgitation

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