US20110101069A1 - Surgical Stapler with Direct Sled to Staple Contact - Google Patents
Surgical Stapler with Direct Sled to Staple Contact Download PDFInfo
- Publication number
- US20110101069A1 US20110101069A1 US12/970,678 US97067810A US2011101069A1 US 20110101069 A1 US20110101069 A1 US 20110101069A1 US 97067810 A US97067810 A US 97067810A US 2011101069 A1 US2011101069 A1 US 2011101069A1
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- United States
- Prior art keywords
- anvil
- staple
- cutter
- arm
- target vessel
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B17/115—Staplers for performing anastomosis in a single operation
- A61B17/1152—Staplers for performing anastomosis in a single operation applying the staples on the outside of the lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B2017/07214—Stapler heads
- A61B2017/07285—Stapler heads characterised by its cutter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B2017/1107—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis for blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B2017/1135—End-to-side connections, e.g. T- or Y-connections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/03—Automatic limiting or abutting means, e.g. for safety
- A61B2090/037—Automatic limiting or abutting means, e.g. for safety with a frangible part, e.g. by reduced diameter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/064—Blood vessels with special features to facilitate anastomotic coupling
Definitions
- the invention relates to an apparatus and method for performing anastomosis.
- Anastomosis is a procedure by which two hollow tissue structures are joined together. More particularly, vascular anastomosis is a procedure by which two blood vessels within a patient are surgically joined together. vascular anastomosis is performed during treatment of a variety of conditions including coronary artery disease, diseases of the great and peripheral vessels, organ transplantation, and trauma.
- coronary artery disease CAD
- an occlusion or stenosis in a coronary artery interferes with blood flow to the heart muscle.
- Treatment of CAD involves the grafting of a vessel in the form of a prosthesis or harvested artery or vein to reroute blood flow around the occlusion and restore adequate blood flow to the heart muscle. This treatment is known as coronary artery bypass grafting (CABG).
- CABG coronary artery bypass grafting
- the suturing process is a time consuming and difficult procedure requiring a high level of surgical skill.
- a surgeon holds the edges of the incision in the target vessel with one handle and holds a needle in the other hand for suturing, or an assistant may hold the edges of the incision in the target vessel while a surgeon makes small stitches as close as possible to the edges of the incision.
- This suturing requires a high degree of precision and is quite time consuming.
- blood flow at the anastomosis site is stopped during suturing.
- a side clamp or other device may be used to isolate a portion of the wall of the aorta to which a graft vessel is sutured.
- the use of a side clamp or similar device can cause emboli to detach from the wall of the aorta and enter the bloodstream, which is undesirable.
- vascular anastomosis system that allows the tissue at the anastomosis site to be controlled during suturing or other connection of the graft and target vessels. It would also be desirable to provide a vascular anastomosis system that allows the connection of a graft vessel to a target vessel prior to making an incision in the target vessel which allows blood flow between the target vessel and the graft vessel.
- an anastomosis tool includes a tissue effector connected to a handle by a shaft or other structure.
- the tissue effector may be orientable relative to the handle and/or shaft.
- the tissue effector may be configured to roll, pitch and/or yaw relative to the shaft. In this way, the tissue effector can be placed in a desired orientation at an anastomosis site, and the handle can be held in a convenient position by the user.
- the tissue effector includes a staple holder moveable relative to an anvil.
- the staple holder holds at least one staple.
- the staple holder and the anvil are movable relative to one another, and move between an open position and a closed position. In the open position, the anvil is configured for insertion into a target vessel.
- the tissue effector may be biased to the open position with a spring or other mechanism or structure. In the closed position, the tissue effector holds the graft vessel against the wall of the target vessel.
- the staple holder includes two or more spaced-apart arms. An end of the graft vessel is cut to form at least one flap therein, and each flap is folded onto an arm of the staple holder.
- One or more graft clips are provided on each arm, where each graft clip secures a corresponding flap to the surface of the arm. Each clip is configured to move between an open position for receiving a flap and a closed position for securing the flap to the corresponding arm of the staple holder.
- Each graft clip may utilize a cam-lock feature or other structure or mechanism to hold itself in the closed position.
- One or more spikes may be provided on each arm, such that the spike or spikes penetrate and hold the corresponding flap to secure it more thoroughly to the staple holder.
- At least one of the arms of the staple holder includes at least one connector bay.
- a staple is held within each connector bay, such as by friction against its walls.
- One or more of the staples may be coated with sodium stearate or other biocompatible lubricant.
- a passage extends though each arm of the staple holder, where one end of each connector bay opens to that passage.
- a connector deployer extends into each connector bay, such that one end of the connector deployer contacts or is in proximity to the corresponding staple.
- One end of each connector bay faces the anvil when the tissue effector is in the closed position, and the other end of each connector bay opens to a channel or other structure.
- the ends of the connector bays facing the anvil are against or in proximity to the flaps of the graft vessel held against the arms of the staple holder, such that deployment of the staples from the connector bays causes those staples to penetrate the flaps.
- a ramp element is movable within each passage.
- the ramp element may be a component of a sled that is movable relative to the staple holder.
- the ramp element urges it into the connector bay.
- that connector deployer urges the corresponding staple along the connector bay and out of the open end of the connector bay.
- the ramp element translates along the channel, it sequentially encounters the connector deployers, thereby sequentially deploying the staples into the corresponding flap and into the wall of the target vessel.
- at least one ramp element may be configured to deploy the staples in another manner, such as substantially simultaneously.
- excess tissue may be incised from the flaps of the graft vessel.
- incising may be performed before, during or after the connection of the graft vessel to the target vessel.
- a vein knife is configured to move relative to a second channel defined in an arm of the staple holder, where the second channel is positioned relative to the flap such that the flap can be to a desired size.
- Each flap may be incised during or after the anastomosis, freeing the graft vessel from the staple holder.
- the vein knife may be connected to the sled directly or indirectly. Thus, as the sled translates along the first channel, the vein knife translates along the second channel and incises the corresponding flap.
- At least one graft clip blade optionally is attached to at least one of the arms of the staple holder.
- the graft clip blade has a serrated edge oriented to engage the corresponding flap of the graft vessel.
- the serrations on the edge of the graft clip blade assist in holding the corresponding flap securely, particularly as the vein knife incises excess tissue from the flap. Additionally, the graft clip blade may participate in incising excess tissue from the corresponding flap. Further, the serrations on the edge of the graft clip blade, in conjunction with the spikes, may assist in holding the excess tissue incised from each flap.
- a cutter translates along a slot in the anvil to create an opening in the wall of the target vessel.
- the timing of the staple deployments are coordinated with the motion of the cutter.
- the sled and the cutter move simultaneously.
- the sled and the cutter are shaped, positioned and/or otherwise configured to connect the graft vessel to the target vessel and to incise an opening in the wall of the target vessel in a coordinated manner.
- the distal end of one or more of the arms of the staple holder may be notched.
- the sled may be positioned such that its distal ends are located at the distal ends of the channels, such that the sled is visible via the notches. In this way, actuation of the sled and thus deployment of the staples can be visually confirmed.
- the handle includes a trigger operationally connected to the tissue effector, providing for actuation of the tissue effector with a single motion of the trigger. That is, a single input to the anastomosis tool both deploys staples and incises the target vessel at the anastomosis site, such that a single input to the tool creates a complete anastomosis between the graft vessel and the target vessel.
- the trigger is connected to a rocker that is configured to engage a proximal slider during actuation of the trigger.
- a first cable or other force transmission structure or mechanism is connected to the proximal slider, as well as to the anvil.
- the first cable is movable relative to a cable housing, which is fixed at one end to the staple holder and at the other end to the shaft.
- the anvil is fixed relative to the shaft as well.
- the tensioning of the first cable causes the staple holder to move closer to the anvil, thereby moving the tissue effector from the open position to the closed position.
- the tissue effector closes without damaging the target vessel within which the anvil is positioned.
- the rocker is configured to engage a distal slider during actuation of the trigger.
- a second cable or other force transmission structure or mechanism is connected to the distal slider, as well as to the sled.
- the rocker releases the distal slider to move proximally, causing the distal slider to pull the second cable proximally.
- the second cable is routed over a bend on the staple holder such that the motion of the second cable pulls the sled in the distal direction.
- the flaps are decoupled from the tissue effector after the anastomosis is complete.
- this decoupling occurs as a result of the depression of the trigger, such that a single control is used to perform the entire anastomosis procedure.
- Decoupling may be performed by incising the flaps, by releasing the graft clips, or in any other appropriate manner.
- FIG. 1 is a perspective view of an anvil and a plurality of staples according to a first aspect of the present invention.
- FIG. 2 is a perspective view of the anvil of FIG. 1 being inserted into a target vessel.
- FIG. 3 is a perspective view of the anvil tenting a wall of a target vessel for an anastomosis procedure.
- FIG. 4 is a perspective view of a graft vessel placed adjacent an exterior of the tented target vessel for the anastomosis procedure.
- FIG. 5 is a perspective view of the staples being applied to the graft vessel and the target vessel during an anastomosis procedure.
- FIG. 6 is a perspective view of the completed anastomosis according to the first aspect of the present invention.
- FIG. 7 is a perspective view of a staple supported on a staple holding strip.
- FIG. 8 is a side view of the staple and staple holding strip of FIG. 7 when the ends of the staple have been bent by contact with an anvil.
- FIG. 9 is a perspective view of an anvil and staple according to another aspect of the present invention.
- FIGS. 10A and 10B are is a side views of a plurality of staples supported on two examples of expandable staple holding strips.
- FIG. 11 is a perspective view of a portion of an anvil having a movable cutting device.
- FIG. 12 is a side view of an anvil having an external cutting device.
- FIGS. 12A and 12B are side views of a portion of an anvil and two cutting devices that snap onto the anvil.
- FIG. 13 is a side view of a portion of an anvil with an extendable cutting device.
- FIG. 14 is a side view of the anvil of FIG. 13 with the cutting device extended.
- FIG. 15 is a side view of a portion of an anvil with an alternate extendable cutting device.
- FIG. 16 is a side view of the anvil of FIG. 15 with the cutting device extended.
- FIG. 17 is a perspective view of an anvil according to a second aspect of the invention being inserted into a target vessel.
- FIG. 18 is a perspective view of the anvil of FIG. 17 positioning inside a target vessel and a clamp being advanced to clamp the wall of the target vessel between the anvil and the clamp.
- FIG. 19 is a perspective view of a graft vessel being advanced to the target vessel with a continuous anastomosis staple while the anastomosis site on the target vessel is controlled by the anvil and clamp.
- FIGS. 20-22 are side cross sectional views of the steps of performing the anastomosis with the continuous anastomosis staple shown in FIG. 19 .
- FIG. 23 is a perspective view of the completed anastomosis performed as shown in FIGS. 19-22 .
- FIGS. 24-27 are perspective views of the steps of an alternative anvil and clamp system for controlling an anastomosis site and forming an incision through the clamped tissue of the target vessel.
- FIG. 28 is a perspective view of a system for controlling a tissue site and performing anastomosis according to the present invention.
- FIG. 29 is a cross sectional view taken along line C-C of FIG. 28 , showing a first step of the anastomosis procedure.
- FIG. 30 is a cross sectional view taken along line C-C of FIG. 28 , showing a second step of the anastomosis procedure.
- FIG. 31 is a cross sectional view taken along line C-C of FIG. 28 , showing a third step of the anastomosis procedure.
- FIG. 32 is a perspective view of an anvil according to another aspect of the present invention for use with sutures.
- FIG. 33 is a perspective view of the anvil of FIG. 32 positioned within a target vessel and used to locate a plurality of suture at an anastomosis site.
- FIG. 34 is a side cutaway view of a first embodiment of an anvil, a cutter and a staple holder, where the anvil and staple holder are spaced apart from each other.
- FIG. 35 is an end cross-section view of the anvil of FIG. 34 .
- FIG. 36 is a side cutaway view of a portion of the anvil inserted into the lumen of a target vessel.
- FIG. 37 is a side view of the cutter.
- FIG. 38 is a perspective view of the cutter of FIG. 37 .
- FIG. 39 is a side view of the distal end of a second embodiment of a cutter.
- FIG. 40 is a side view of the distal end of a third embodiment of a cutter.
- FIG. 41 is a side view of the distal end of a fourth embodiment of a cutter.
- FIG. 42 is a side view of a portion of a fifth embodiment of a cutter.
- FIG. 43 is a side view of the distal end of a sixth embodiment of a cutter.
- FIG. 43A is a side view of another embodiment of a cutter.
- FIG. 43B is a side view of another embodiment of a cutter.
- FIG. 44 is a side cutaway view of the anvil and staple holder of FIG. 34 , where the cutter is in a first position.
- FIG. 45 is a side cutaway view of the anvil and staple holder of FIG. 34 , where the cutter is in a second position.
- FIG. 46 is a side cutaway view of the anvil and staple holder of FIG. 34 , where the cutter is in a third position.
- FIG. 47 is a side cutaway view of the anvil and staple holder of FIG. 34 , where the cutter is in a fourth position.
- FIG. 48 is a side cutaway view of the anvil and staple holder of FIG. 34 , where the cutter is in a fifth position.
- FIG. 49 is a side cutaway view of a second embodiment of an anvil and a staple holder, where the anvil and staple holder are spaced apart from each other.
- FIG. 50 is a side cutaway view of the anvil and staple holder of FIG. 40 , where the cutter is in a first position.
- FIG. 51 is a side cutaway view of the anvil and staple holder of FIG. 40 , where the cutter is in a second position.
- FIG. 52 is a side cutaway view of the anvil and staple holder of FIG. 40 , where the cutter is in a third position.
- FIG. 53 is a side cutaway view of the anvil and staple holder of FIG. 40 , where the cutter is in a fourth position.
- FIG. 54 is a side cutaway view of the anvil and staple holder of FIG. 40 , where the cutter is in a fifth position.
- FIG. 55 is a side view of an anastomosis tool having a tissue effector and a handle.
- FIG. 56 is a perspective view of the tissue effector of FIG. 55 in first position.
- FIG. 57 is a perspective view of the tissue effector of FIG. 55 in a second position.
- FIG. 58 is another perspective view of the tissue effector of FIG. 55 in the first position.
- FIG. 59 is a perspective view of the tissue effector of FIG. 55 in the first position, with a graft vessel being connected to it.
- FIG. 59A is a detail cross-section view of a cam lock used in the tissue effector of FIG. 55 , where the cam lock is in an open position.
- FIG. 59B is a detail cross-section view of the cam lock of FIG. 59A in a closed position.
- FIG. 59C is an end view of the left half of the tissue effector of FIG. 55 , in the closed position.
- FIG. 59D is an end view of the right half of another embodiment of the tissue effector of FIG. 55 , in the closed position.
- FIG. 60 is a detail side view of a portion of the tissue effector of FIG. 55 , showing an embodiment of a graft clip.
- FIG. 61 is a detail end view of a portion of the tissue effector of FIG. 55 .
- FIG. 62 is a side view of a vein knife used in the tissue effector of FIG. 55 .
- FIG. 63 is a side view of a graft clip blade used in the tissue effector of FIG. 55 .
- FIG. 64 is a cross-section view of section A-A of FIG. 57 .
- FIG. 65 is a perspective view of a connector deployer used in the arm of FIG. 64 .
- FIG. 66 is a side view of a portion of the arm of FIG. 64 as defined by the line B-B of FIG. 64 .
- FIG. 67 is a perspective view of a staple configured to be deployed from the tissue effector of FIG. 55 .
- FIG. 68 is a perspective view of a sled used in the tissue effector of FIG. 55 .
- FIG. 69 is a bottom view of the sled of FIG. 68 .
- FIG. 69A is a side view of the sled of FIG. 68 .
- FIG. 70 is a side cross-section view of the handle of FIG. 55 in a first position.
- FIG. 71 is a top view of a portion of a rocker utilized in the handle of FIG. 55 .
- FIG. 72 is a side cross-section view of the handle of FIG. 55 in a second position.
- FIG. 73 is a perspective view of a completed anastomosis.
- FIG. 74 is a perspective view of the tissue effector of FIG. 55 with a graft vessel loaded onto it.
- FIG. 75 is a perspective view of the tissue effector of FIG. 74 , where the anvil of the tissue effector has been inserted into the lumen of a target vessel.
- FIG. 76 is a perspective view of the tissue effector of FIG. 74 , after the graft vessel has been connected to the target vessel and before the anvil of the tissue effector has been removed from the lumen of the target vessel.
- FIG. 77 is a graph qualitatively illustrating the positions of the distal slider and the proximal slider of the handle over time, with regard to an arbitrary point between them.
- an anvil 10 includes a handle 12 and an anvil arm 14 extending from the handle 12 .
- the anvil arm 14 may be oriented substantially perpendicular to the handle 12 , or oriented at a different angle.
- the anvil arm 14 may be provided with one or more staple bending features 16 on opposite sides of the anvil arm 14 .
- the staple bending features 16 each include a plurality of recesses 20 which receive the ends of staples 22 and cause the staple ends to bend over. At least one of the staple bending features 16 may be configured differently or omitted, if desired.
- the staples 22 may be connected to a staple holding strip 24 .
- the staples 22 are U-shaped and are arranged in a spaced apart parallel configuration such that the staples 22 all lie in a single plane. Alternately, the staples 22 may be shaped differently, and/or lie in one or more different planes.
- An exemplary anvil arm 14 has a height and a width of about 2 mm or less, advantageously about 1 mm or less, and a length of about 2 to 15 mm, advantageously 5 to 12 mm.
- the length of the anvil will vary depending on the diameter of the graft vessel selected.
- the length to width ratio of the anvil arm 14 is substantially between 2:1 and 15:1. A different length to width ratio may be used, if desired.
- the staples 22 have widths of about 0.2-3 mm.
- the staples 22 have widths of substantially 2 mm or less.
- the leg lengths of the staples 22 are substantially 0.2-3 mm. Alternately, other staple widths and/or leg lengths may be used.
- the anvil arm 14 has a sharp distal end 28 for puncturing the tissue of a target vessel to insert the anvil arm 14 into the target vessel.
- the anvil arm 14 is inserted into a pressurized or unpressurized target vessel 30 by puncturing the target vessel with the distal end 28 of the anvil arm 14 .
- the hole that is formed in the wall of the target vessel 30 by the anvil arm 14 is small enough to prevent significant bleeding through the puncture site.
- the hole is closed by hand suturing.
- the hole is closed with a biocompatible glue, adhesive or the like.
- the hole is closed with a clip, clamp, or other implantable device that remains on the target vessel.
- Such a device may be positioned on the outer surface and/or inner surface of the target vessel, and may extend into the hole.
- a device for closing the hole may be constructed from nitinol or other superelastic or pseudoelastic material, or from stainless steel or other material, where that device moves between a first configuration and a second configuration during deployment, and where the second configuration holds the hole closed.
- the hole is less than substantially 2 mm wide, and advantageously less than 1 mm wide.
- the anvil arm 14 has a blunt distal end 28 that is inserted through a hole created with a separate instrument, by a different instrument connected to the anvil arm 14 , or by a sharp member connected to the anvil arm 14 that can be refracted into the anvil arm 14 or otherwise blunted or concealed after puncturing or creating an incision in the wall of the target vessel.
- the anvil arm 14 may be pulled against an inner wall of the target vessel 30 , causing tenting of the thin tissue of the vessel wall as illustrated in FIG. 3 .
- This tenting of the vessel wall provides control over the anastomosis site during an anastomosis procedure that is described with respect to FIGS. 4-6 .
- tenting of the target vessel wall need not be tented in order to control the anastomosis site during the anastomosis procedure.
- a graft vessel 32 is advanced to the anastomosis site and an end 34 of the graft vessel 32 is positioned adjacent an exterior surface of the target vessel 30 at the anastomosis site.
- the tented portion of the target vessel 30 is positioned within the perimeter of the end 34 of the graft vessel 32 .
- a staple holder 38 is provided having two arms 40 which are pivotally connected to the handle 12 of the anvil 10 .
- the pivoting arms 40 of the staple holder 38 may be connected to the handle 12 in a different way, or may be connected to a separate or additional device.
- the arms 40 are spaced apart from one another across at least a part of their length.
- the graft vessel can be positioned between the arms 40 . That is, the arms 40 are positioned on substantially opposite sides of the graft vessel. In this way, each arm 40 may be positioned against a flap at an end of the graft vessel, as illustrated in FIGS. 29-31 .
- the arms 40 may be configured differently, if desired.
- the staple holder 38 may be used to hold individual staples 22 and/or staple holding strips 24 .
- each arm 40 of the staple holder 38 carries one row of staples 22 or one staple holding strip 24 , where the staples 22 are arranged in a substantially linear row.
- staples 22 or staple strips 24 may be arranged in two or more rows, parallel or otherwise, on one or more arms 40 .
- the staples 22 may be staggered on one or more arms, such that at least one row of staples 22 does not fall along a straight line.
- the staples 22 or staple strips 24 may be arranged or aligned in any manner on each arm 40 that results in a secure anastomosis between the graft vessel and the target vessel.
- the staples 22 are inserted through the flaps at the end of the graft vessel 32 , or another portion of the target vessel, and into the target vessel 30 by pivoting the arms 40 of the staple holder 38 towards the anvil arm 14 .
- the staple bending features 16 are positioned in a configuration corresponding to the configuration of the staples 22 , such that each staple 22 engages a corresponding staple bending feature 16 during deployment.
- the staple holder 38 is a mechanism that deploys connectors other than or in addition to staples 22 .
- FIG. 6 illustrates a completed anastomosis between a target vessel 30 and a graft vessel 32 with a plurality of staples 22 .
- the spacing between the staples 22 is approximately 1 to 4 mm. This spacing is similar to the spacing between sutures in a conventional sutured anastomosis. A different spacing between the staples 22 may be used if desired.
- the anvil arm 14 is withdrawn from the target vessel 30 between adjacent staples 22 . The withdrawal of the anvil arm 14 leaves a gap that is approximately the same as the spacing between adjacent staples. Accordingly, substantially no blood leakage occurs at the location where the anvil arm has been withdrawn.
- FIGS. 7 and 8 illustrate one example of a staple 22 connected to a staple holding strip 24 .
- This staple 22 includes barbed staple ends 52 extending from the front portion of the staple 22 and a C-shaped portion 54 extending from a rear of the staple 22 for connecting the staple 22 to the staple holding strip 24 .
- the staple holding strip 24 includes a plurality of protrusions 56 for receiving the staples 22 .
- the C-shaped portion 54 of each staple 22 is received around one of the protrusions 56 and is secured in place at one or more locations, such as by welds 58 or by a frangible linkage or connection. Alternately, the C-shaped portion 54 of each staple 22 may be secured to the staple-holding strip 24 in a different way. As shown in FIG.
- the staple 22 may be detached from the staple holding strip 24 by the action of bending the barbed staple ends 52 such that the C-shaped portion 54 of the staple 22 splays outward and breaks apart from the corresponding protrusion 56 on the staple holding strip 24 , by bending a frangible connection between the staple holding strip and the staples to separate the staples, or any other known separation methods, such as melting of a connection between the staple and the staple holding strip.
- FIG. 9 illustrates an alternate staple 22 a having inwardly curved barbed staple ends 52 a .
- the staple ends 52 a are themselves curved, the corresponding staple bending feature or features 16 a need not be curved to bend the ends 52 a of the staples 22 a .
- the staple bending features 16 a on each side of the anvil arm 14 a may be formed as a single longitudinal groove along the anvil arm 14 a , where the staple bending feature 16 a has a substantially flat surface.
- the staple may be configured differently.
- two or more different kinds of staples are deployed by the staple holder 38 in order to form a single anastomosis.
- a plurality of staples 22 a are positioned on an expandable staple holding strip called an expandable backbone 66 .
- the expandable backbone 66 includes a plurality of elements 68 which are interconnected by one or more expanding members 70 .
- Each of the backbone elements 68 is provided with a connecting diamond member 72 that is connected to one of the staples 22 a .
- each staple 22 a is connected to the corresponding diamond member 72 by a thin connecting section 74 .
- the expandable backbone 66 allows the spacing between the staples 22 a to be adjusted for the particular anastomosis to be performed.
- the backbone 66 allows expansion of the distance between staples from a distance of approximately 0.1 mm to a distance of approximately 1 to 4 mm, i.e., expansion of up to 40 times the original spacing. Alternately, the backbone 66 allows a different amount of expansion.
- the expanding backbone 66 also includes two openings 76 at opposite ends which may be engaged by holding pins (not shown) on an anastomosis system or staple holder. The opening 76 allow the backbone 66 to be easily expanded by relative motion of the holding pins.
- the connecting diamond members 72 are configured to collapse inwardly toward the backbone when the staples 22 a engage the staple bending surface or surfaces 16 a of the anvil.
- each diamond member 72 forces the corresponding staple 22 a to separate from the diamond member 72 at a connecting section 74 .
- the connecting section 74 is a frangible linkage connecting a staple 22 a to a corresponding diamond member 72 .
- FIG. 10B illustrates another example of staples 22 a detachably connected to a backbone 66 .
- the staples 22 a are each connected to the associated backbone elements 68 at two connecting sections 74 .
- the staples 22 a , backbone 66 , and associated components are substantially as described above with regard to FIG. 10A .
- FIG. 11 shows a portion of an anvil arm 14 with a movable cutting device 44 .
- the cutting device 44 includes a base 46 and a blade 48 .
- the base 46 of the cutting device 44 is positioned in a longitudinal groove 50 in the anvil arm 14 .
- the cutting device 44 may be moved longitudinally along the anvil arm 14 to form an incision in the target vessel.
- FIGS. 12 , 12 A, and 12 B illustrate external cutting devices that are advanced down onto the anvil arm 14 after the anastomosis procedure and cut an incision in the target vessel from an exterior of the target vessel as the anvil arm 14 is withdrawn.
- a knife 62 is positioned on a knife arm 64 that is movable along the handle 12 of the anvil. The knife 62 is moved downward in a direction substantially parallel to the longitudinal axis of the handle 12 until the knife 62 engages a recess 65 in the anvil arm 14 . The knife 62 is thereby positioned substantially at the anastomosis site.
- the end of the graft vessel is then placed substantially against the wall of the target vessel at the anastomosis site, over the knife 62 and knife arm 64 .
- the knife 62 forms an incision in the target vessel.
- the knife 62 and knife arm 64 exit the anastomosis site via the joint between the graft vessel and the target vessel.
- the withdrawal of the anvil arm 14 , knife 62 and knife arm 64 leaves a gap in the wall of the target vessel that is approximately the same as the spacing between adjacent staples to minimize or eliminate leakage through that gap.
- the knife 62 may be moveable relative to the handle 12 in at least one direction in addition to a direction substantially parallel to the longitudinal axis of the handle 12 .
- the knife 62 may be moveable in a direction substantially parallel to the wall of the target vessel to create an arteriotomy in the target vessel at the junction between the graft vessel and the target vessel.
- FIGS. 12A and 12B illustrate two alternate examples of the knife 62 which snap onto a corresponding engagement surface 65 of the anvil arm 14 so that the knife and anvil are secured together for formation of the incision during removal of the anvil arm 14 from the anastomosis site.
- FIGS. 13-16 illustrate two variations of extendable cutting devices for making an incision in the target vessel while withdrawing the anvil arm 14 from the target vessel.
- FIG. 13 illustrates an anvil arm 14 b having a blade 78 connected to a flexible blade support 80 .
- the blade support 80 is pulled in the direction of the arrow A with respect to the anvil arm 14 b , the blade 78 moves from a forwardly extending position shown in FIG. 13 to an upwardly extending position shown in FIG. 14 as a result of flexure of the blade support 80 .
- the blade 78 in the forwardly extending position may be used to form a small opening in the wall of the target vessel through which the anvil arm 14 is inserted into the target vessel.
- the blade 78 is moved to an upwardly angled or a vertical position in which the blade 78 is used to form an incision in the target vessel as the anvil arm 14 b is removed from the target vessel.
- FIGS. 15-16 illustrate an alternate example of an anvil arm 14 c having a blade 84 and a blade support 86 . While the anvil arm 14 c is inserted into the target vessel and during the anastomosis procedure, the blade 84 is positioned in a recess 88 in the anvil arm. The blade 84 may be moved from the position of FIG. 15 to the extended position of FIG. 16 by moving the blade support 86 in the direction of the arrow B with respect to the anvil arm. The blade 84 is flexible and stressed, such that freeing the blade 84 from the recess 88 causes the blade 84 to move to the extended position. Alternatively, the blade 84 may be extended automatically upon withdrawal of the anvil arm 14 when a blade tip 90 catches on an interior surface of the target vessel wall during withdrawal of the anvil arm.
- the extendable cutting devices shown in FIGS. 13-16 are merely shown as examples of the type of cutting devices which may be used for making the incision. Once these cutting devices or blades have been extended from the anvil arm, they may be fixed to perform cutting as the anvil arm is removed from the target vessel or the blades may be movable along the anvil arm to make an incision prior to removal of the anvil arm from the target vessel.
- the anastomosis tool 300 includes a handle 302 , a shaft 304 connected to the handle 302 , a cable housing 306 connected at one end to the handle 302 , and a tissue effector 400 connected to both the shaft 304 and the cable housing 306 .
- the anastomosis tool 300 may be configured differently, if desired.
- the cable housing 306 may be omitted, and the cable or cables (not shown) that would otherwise extend therethrough are instead routed through the shaft 304 .
- the handle 302 and/or the tissue effector 400 may be detachable from the shaft 304 to allow for interchangeability of these components.
- the same handle 302 may be used to perform more than one anastomosis within a single patient, where a different tissue effector 400 may be connected to that handle 302 for each anastomosis.
- the handle 302 may be constructed from materials that can be sterilized, such as by an autoclave, and reused.
- the handle 302 may assume any appropriate configuration; the shape and configuration of the handle 302 described herein is exemplary and not limiting.
- the shaft 304 may be a rigid hollow structure such as a tube of stainless steel, but may be shaped differently and/or fabricated from a different material. Further, the shaft 304 may be flexible at least in part, rather than rigid.
- the shaft 304 may be omitted altogether, such that the handle 302 is connected to the tissue effector 400 by one or more cables that would otherwise have extended through the shaft 304 .
- the handle 302 includes a trigger 308 that provides for actuation of the anastomosis tool 300 based solely on a single input to that trigger 308 , as described in greater detail below.
- additional inputs may be utilized to actuate the anastomosis tool 300 .
- actuation of the anastomosis tool 300 may be based on an input to one or more buttons in addition to the trigger 308 .
- the tissue effector 400 includes an anvil 10 and a staple holder 38 .
- the tissue effector 400 may be permanently fixed to the shaft 304 , or may be detachable from it such that is it decoupled from the handle 302 . That is, tissue effectors 400 may be interchangeable.
- the shaft 304 is not provided, and the tissue effector 400 is directly coupled to the handle 302 .
- One end of the cable housing 306 is fixed to the staple holder 38 .
- the anvil 10 of the tissue effector 400 may be as described above, or may be configured differently.
- the anvil 10 also includes a cutter 200 that is moveable relative to the anvil 10 for making an incision in the wall of a target vessel.
- a tissue stop 220 is formed into or connected to the anvil 10 .
- the portion of the anvil 10 distal to the tissue stop 220 is configured to penetrate into the wall of a target vessel, and may be referred to as the anvil arm 14 .
- a channel 246 is defined within the anvil arm 14 , through which a cutter 200 is configured to move.
- the cutter 200 is narrower than the channel 246 , such that interior surfaces 202 on either side of the channel 246 may guide the translation of the cutter 200 relative to the anvil arm 14 .
- translation refers to motion of the cutter 200 in the distal or proximal direction, whether or not the cutter 200 or a portion thereof moves upward or downward during that motion.
- the direction substantially perpendicular to the longitudinal centerline of the anvil arm 14 toward the wall of the target vessel may be referred to as “upward”, and the direction substantially perpendicular to the longitudinal centerline of the anvil arm 14 away from the wall of the target vessel may be referred to as “downward”.
- the positioning of the anvil arm 14 in use is not limited to an orientation in which these directions correspond to absolute directions measured relative to the ground.
- motion upward or downward may be referred to as “vertical” motion
- motion substantially parallel to the longitudinal centerline of the anvil arm 14 may be referred to as “horizontal” motion.
- the anvil arm 14 includes a contact surface 206 .
- the contact surface 206 of the anvil arm 14 is placed substantially against the inner surface 203 of a target vessel 201 .
- the contact surface 206 substantially defines a place that is substantially parallel to the longitudinal centerline of the anvil arm 14 .
- the contact surface 206 is contoured and/or oriented differently.
- An upper opening 248 extends along at least a portion of the contact surface 206 in a direction substantially parallel to the longitudinal centerline of the anvil arm 14 , and opens into the channel 246 .
- the upper opening 248 may divide the contact surface 206 into symmetrical or asymmetrical sections.
- the contact surface 206 may be formed by two substantially planar surfaces, by one substantially planar surface and a differently-shaped surface, or by another set of surfaces. Additionally, the contact surface 206 may be formed by two thin edges, each edge occurring at the intersection of a wall of the upper opening 248 and an outer surface of the anvil arm 14 .
- the upper opening 248 need not extend proximally any further than the tissue stop 220 . However, the upper opening 248 may extend proximal to the tissue stop 220 , if desired.
- a first lower opening 254 and a second lower opening 268 are defined through a lower surface 256 of the anvil arm 14 .
- the lower surface 256 of the anvil arm 14 may be substantially parallel to the contact surface 206 or may be oriented differently relative to the contact surface 206 .
- the first lower opening 254 and/or the second lower opening 268 do not extend completely through the anvil arm 14 , and instead are depressions extending along at least part of a bottom surface 266 of the channel 246 .
- the cutter 200 is a thin, rigid member, shaped such that it can be held within the channel 246 in the anvil arm 14 .
- the cutter 200 has a substantially constant width along its entire length. Alternately, the width of the cutter 20 may vary along its length.
- the cutter 200 may be made of metal, ceramic, plastic, or other material, or from a combination of different materials.
- a sharp projection 208 extends upward from the cutter 200 at or near its distal end.
- the projection 208 is substantially triangular, but may be shaped differently.
- the projection 208 may be smooth or serrated, or otherwise shaped or formed.
- a portion of the projection 208 may be ground or otherwise honed to a sharp edge to facilitate the motion of the projection 208 through the tissue of the wall of a target vessel, as described in greater detail below.
- the cutter 200 is composed of a material that can be sharpened adequately to cut tissue.
- the cutter 200 may be flexible, at least in part.
- the projection 208 may be located at a different position on the cutter 200 than at or near its distal end.
- An additional sharp point (not shown) may be provided at the distal end of the cutter 200 , extending in a distal direction, in order to create an initial puncture or incision in the wall of the target vessel. Such a point may be as described in U.S. patent application Ser. No. 10/134,081, which is herein incorporated by reference in its entirety.
- One or more additional projections 208 may be provided, if desired.
- two or more projections 208 may extend upward from the cutter 200 . Where multiple projections 208 are used, they may cooperate with one another to create an incision in the wall of the target vessel.
- a second projection 208 extends upward from the cutter 200 proximal to a first projection 208 .
- the projections 208 are both substantially the same triangular shape and the same size. However, the projections 208 may be shaped and sized differently.
- the projections 208 are both substantially planar, and are aligned such that both projections 208 lie in substantially the same plane.
- Each projection 208 may include at least one sharpened or beveled edge 209 oriented to engage and incise the wall of the target vessel when the cutter 200 is translated, as described below.
- at least two projections 208 extend upward from the cutter 200 .
- the projections 208 each have a barb 211 at the tip. However, the barb 211 may be omitted from some or all of the projections 208 .
- Under the barb 211 a sharpened or beveled edge 209 extends downward and proximally.
- the edge 209 may be straight or curved. The upper end of the edge 209 is distal to the lower, proximal end of the corresponding barb.
- each projection 208 is oriented to engage and incise the wall of the target vessel when the cutter 200 is translated.
- at least two projections 208 extend upward from the cutter 200 , at least one of which has a barb 211 at its tip.
- the edge 209 associated with each projection 208 is more curved than the edge 209 shown in FIG. 40 .
- the edge 209 is substantially straight, or gently curved, or positioned on a portion of a larger curved segment 213 extending downward from and proximal to the barb 211 .
- a number of projections 208 may be placed along a length of the cutter 200 .
- This length may be comparable to the desired length of the incision in the wall of the target vessel.
- These projections 208 may be substantially triangular as shown, or may be shaped differently. Where more than one projection 208 is used on the cutter 200 , the projections 208 need not have the same configuration. For example, projections 208 such as the exemplary projections 208 shown in FIGS. 39-41 may be mixed together on the same cutter 200 . Alternately, one or more of the projections 208 are moveable relative to the cutter 200 , such that one or more projections 208 can be moved upward or downward relative to the cutter 200 .
- the projections 208 extending upward from the cutter 200 each are substantially planar, and are aligned such that not all of the projections 208 lie in the same plane.
- the projections 208 may create a wider incision in the wall of the target vessel than would be created if the projections 208 were substantially aligned.
- one set of projections 208 may be aligned substantially in a first plane, and a second set of projections 208 may be aligned substantially in a second plane substantially parallel to the first plane.
- the second plane and the first plane may be oriented differently relative to one another, if desired.
- none of the projections 208 lie in a common plane with one or more other projections 208 .
- the cutter 200 need not be translated as far to make an incision in the wall of the target vessel as it would if only a single projection 208 were used, as described in greater detail below.
- an interior surface 202 is located on each side of the channel 246 .
- Each interior surface 202 may be substantially planar, curved, or may be shaped differently. Further, each interior surface 202 may be oriented at an angle to vertical or substantially vertical.
- the interior surfaces 202 may be formed such that the channel 246 is substantially bilaterally symmetrical, or may be formed to result in a channel 246 that is not bilaterally symmetrical.
- the interior surfaces 202 of the channel 246 within the anvil arm 14 may include raised features 204 that correspond to depressed staple bending features (not shown) on the outer surface of the anvil arm 14 .
- the depressed staple bending features result in corresponding raised features 204 on the interior surface 202 of the channel 246 .
- the raised features 204 do not interfere with the motion of the cutter 200 through the channel 246 . Alternately, the raised features 204 are not present on the interior surface 202 of the channel 246 .
- a safety feature 210 may be connected to the underside of the anvil 10 .
- the safety feature 210 is biased toward the anvil 10 and the cutter 200 .
- the safety feature 210 may be biased into the channel 246 within the anvil 10 .
- the safety feature 210 is connected to a different location, such as the underside of the anvil arm 14 .
- the safety feature 210 may be flexible or rigid.
- the safety feature 210 includes a tip 212 that is oriented substantially transverse to the longitudinal centerline of the cutter 200 . Alternately, the tip 212 may be oriented in a different direction.
- the cutter 200 may include a safety recess 214 defined in it, corresponding to the tip 212 of the safety feature 210 .
- the tip 212 is shaped and sized such that it can engage the safety recess 214 .
- the tip 212 may be a bar or rod oriented substantially transverse to the direction of translation of the cutter 200 , or may be shaped or oriented differently.
- the staple holder 38 has not yet been moved into position to perform anastomosis.
- the tip 212 of the safety feature 210 is biased upward to engage the safety recess 214 .
- the engagement between the safety recess 214 and the tip 212 of the safety feature 210 substantially prevents translation of the cutter 200 within the channel 246 .
- the cutter 200 and the projection 208 are prevented from deploying until the staple holder 38 has been moved into the appropriate position relative to the anvil arm 14 , and inadvertent deployment of the cutter 200 is prevented.
- the cutter 200 includes an engagement member 216 extending upward from a location at or near its proximal end.
- the engagement member 216 instead may extend downward from the cutter 200 or to the side of the cutter 200 . Further, the engagement member 216 may be positioned at a location other than at or near the proximal end of the cutter 200 .
- the engagement member 216 is configured to engage at least a portion of a corresponding receiver 218 in the staple holder 38 . Thus, after engagement between the engagement member 216 and the receiver 218 , translation of the receiver 218 results in translation of the cutter 200 .
- the receiver 218 is a structure that is at least partially open on its underside and that includes at least one surface 219 configured to engage the engagement member 216 . As shown in FIG.
- the surface 219 is a partially-curved surface shaped to receive the curved upper end of the engagement member 216 .
- the receiver 218 may be a flat vertical surface, a curved surface, a structure such as an inverted cup that is open on its underside and that has a wall or walls encircling the engagement member 216 , or any other structure or mechanism capable of engaging the engagement member 216 and urging it distally.
- the receiver 218 may be defined in a sled 482 , which is described in greater detail below.
- An anvil insert 222 is fixed to the anvil 10 .
- the anvil 10 is wider proximal to the anvil arm 14 , open at its top with a space therein.
- the anvil insert 222 can be inserted into the anvil 10 through its top, such that the anvil insert 222 is partially or completely positioned within the anvil 10 .
- the anvil insert 222 may be connected to the anvil 10 in another way.
- the anvil insert 222 is connected to and capable of motion relative to the anvil 10 .
- the anvil insert 222 instead may be connected to the proximal end of the anvil arm 14 , or another location on the anvil arm 14 .
- a cavity 228 is defined within the anvil insert 222 .
- An aperture 230 is defined through the distal end of the anvil insert 222 into the cavity 228 , connecting the channel 246 in the anvil arm 14 and anvil 10 to the cavity 228 .
- the cutter 200 extends through the aperture 230 , such that the distal end of the cutter 200 is positioned within the channel 246 and the proximal end of the cutter 200 is positioned within the cavity 228 .
- a cutter stop 236 may be formed into or connected to the anvil insert 222 , or formed into or connected to the anvil 10 itself or another structure or mechanism. The cutter stop 236 may engage the proximal end of the cutter 200 if the cutter 200 is moved to a defined position within the cavity 228 , thereby restricting its proximal translation.
- a cavity 262 may be defined within the staple holder 38 or a separate component connected to the staple holder 38 .
- a post 258 is positioned at the upper end of the cavity 262 , where the post 258 is oriented downward.
- a biasing element 260 is connected at one end to the post 258 .
- the biasing element 260 may be a coil spring, a leaf spring, a different type of spring, an elastomer, a wire form, or other structure or mechanism capable of exerting a biasing force.
- the biasing element 260 is positioned within and protected by the cavity 262 , where the cavity 262 is used.
- the cavity 262 may be a cylindrical opening having a diameter substantially the same as the outer diameter of the biasing element 260 , such that the cavity 262 restricts the biasing element 260 to motion substantially along the axis of the cavity 262 and thus directs the force exerted by the biasing element 260 in a substantially downward direction, preventing bending or other undesirable motion of the biasing element 260 .
- the biasing element 260 may be a compression spring that is compressed between the post 258 and the cutter 200 , resulting in a force on the cutter 200 that biases the cutter 200 downward.
- the cutter 200 is slidable relative to the biasing element 260 , such that the biasing element 260 exerts a downward force on the cutter 200 at different locations along its upper surface 252 as the cutter 200 translates.
- at least the distal end of the cutter 200 is biased downward throughout its translation along the anvil 10 .
- the entire cutter 200 may be biased downward, if desired.
- the post 258 is omitted, and the biasing element 260 is fixed to an upper surface of the cavity 260 .
- the biasing element 260 is omitted, and the cutter 200 is biased downward in another way.
- the cutter 200 may be constructed from an elastic or superelastic material that is formed in such a way as to produce a downward bias.
- the anvil 10 may include one or more attachment features 270 .
- the attachment features 270 provide a location for attachment of one or more cables or other force transmission structures or mechanisms.
- the attachment features 270 may be one or more passages 270 through the cutter stop 236 .
- the cutter stop 236 may include two or more spaced-apart members. If so, the attachment features 270 may be substantially aligned with one another, or offset from one another. However, the cutter stop 236 may be a single member, if desired.
- one or more of the attachment features 270 are separate from the cutter stop 236 , and are positioned at a different location on the anvil 10 .
- one or more of the attachment features 270 may extend in a direction from the anvil 10 that is other than upward.
- the configuration of the attachment features 270 is related to the configuration of the cable or other force transmission structure or mechanism attached to it, such that the connection between them is secure.
- the cutter stop 236 includes two spaced-apart members, and the attachment features 270 are passages through the upper portion of each member of the cutter stop 236 .
- Two separate cables are connected to the attachment features 270 .
- the end of each cable is passed through one of the attachment features 270 , after which it is welded, connected with adhesive, clamped, tied or otherwise secured to the cutter stop 236 .
- a single first cable is passed through each of the attachment features 270 , such that the free ends of the first cable are spaced apart from the attachment features 270 . In this way, no additional steps are needed to secure the first cable to the attachment features 270 .
- the cable may be welded, connected with adhesive, clamped, tied or otherwise secured to the cutter stop 236 , if desired.
- the anvil 10 extends proximally to a pivot point such as a pin 226 .
- the pivot point may be any other structure or mechanism that allows the anvil 10 to rotate about it.
- the anvil insert 222 extends to the pin 226 instead of or in addition to the anvil 10 .
- the pin 226 pivotally connects the staple holder 38 to the anvil 10 .
- the pin 226 may be formed into or otherwise fixed to the staple holder 38 or anvil 10 , if desired.
- the anvil 10 and/or anvil insert 222 may extend still further proximally from the pin 226 .
- the anvil 10 extends proximally to the pin 226 .
- the anvil insert 222 also extends proximally to the pin 226 , and additionally extends as far as or further proximally to the proximal end of the anvil 10 .
- a proximal portion of the anvil insert 222 may be bent upward relative to a distal portion of the anvil insert 222 .
- the proximal portion of the anvil insert 222 may be referred to as the spine 272 .
- the spine 272 need not be bent upward relative to the proximal portion of the anvil insert 222 , and instead may be bent downward or oriented substantially parallel to the proximal portion of the anvil insert 222 .
- the spine 272 is a separate structure or mechanism that is connected to the anvil insert 222 .
- a post 274 may be defined in or connected to the spine 272 .
- the post 274 may be cylindrical, or may be shaped differently.
- the spring 276 is a coil spring, but may be a different type of spring if desired.
- the other end of the spring 276 is connected to the staple holder 38 , such as to an attachment member 275 defined in or connected to the staple holder 38 .
- the attachment member 275 may be cylindrical, or may be shaped differently.
- the spring 276 may be connected to the post 274 and to the attachment member 275 by hooking an end of the spring 276 to each, by welding, by adhesive, or by any other appropriate structure, mechanism or method.
- the spring 276 may be connected to the staple holder 38 and/or the spine 272 in a different way, if desired.
- the spring 276 is sized and configured to be in tension, so as to bias the tissue effector 400 to an open position. That is, the spring 276 presses the staple holder 38 about the pin 226 , toward the spine 272 of the anvil insert 222 .
- buttons 278 are connected to the spine 272 .
- the wing or buttons 278 may be spaced apart from the spine 272 and connected to it by one or more connection members 280 .
- the buttons 278 each may be sized and shaped for contact with a user's finger.
- two buttons 278 may be sized and shaped such that a user may conveniently press one with a thumb and the other with a forefinger.
- the precise shape and size of the buttons 278 is not critical to the invention.
- at least one button 278 is connected to a cog 282 that in turn connects to the shaft 304 of the anastomosis tool 300 , as described in greater detail below.
- the cog 282 includes one or more teeth 284 .
- the cog 282 is substantially circular, and the teeth 284 extend substantially radially outward from it.
- the staple holder 38 includes two arms 402 , where those arms 402 are spaced apart from one another at least at one end. More or fewer arms 402 may be provided.
- the arms 402 extend distally from the remainder of the staple holder 38 .
- the arms 402 may be positioned differently, if desired.
- the arms 402 are generally linear in configuration, and the longitudinal centerlines of the arms 402 are substantially parallel to one another.
- the arms 402 may be shaped differently and/or oriented differently relative to one another.
- One or more of the arms 402 may be angled relative to a horizontal plane to facilitate connecting the flaps of the graft vessel to the wall of the target vessel.
- the arms 402 are spaced apart from one another at least at one end to allow a graft vessel 404 to be placed between them, and to allow the tissue effector 400 to be freed from the completed anastomosis.
- each arm 402 includes a flap receiving surface 406 .
- Each flap receiving surface 406 is substantially flat across at least a portion of its area.
- Each flap 408 at the end of the graft vessel 404 is placed onto a corresponding flap receiving surface 406 , and the main body of the graft vessel 404 extends between the arms 402 of the staple holder 38 .
- each flap 408 is substantially flat against the corresponding flap receiving surface 406 .
- One or more of the flap receiving surfaces 406 may include a ridged region 413 that has individual ridges 416 spaced apart from one another. The individual ridges 416 may be parallel to one another, or oriented differently. The ridges 416 extend away from the flap receiving surface 406 .
- each flap receiving surface 406 includes a ridged region 413 in proximity to its inner edge.
- the term “inner” refers to proximity to the space between the arms 402
- the term “outer” refers to distance from the space between the arms 402 .
- two flaps 408 are present at the end of the graft vessel 404 .
- These flaps 408 may be created in any appropriate manner, such as by incising the end of the graft vessel 404 with a scalpel.
- the end of the graft vessel 404 may have more than two flaps 408 .
- the end of the graft vessel 404 may have a single flap 408 . That is, a single incision may be made at the end of the graft vessel 404 , substantially parallel to its centerline.
- a single flap 408 is created that extends substantially continuously around the circumference of the end of the graft vessel 404 , where the opposite ends of the flap 408 are adjacent to the incision.
- one or more spikes 410 may extend outward from at least one of the flap receiving surfaces 406 . As at least one of the flaps 408 is placed onto the corresponding flap receiving surface 406 , one or more of the spikes 410 penetrate that flap 408 partially or completely, thereby assisting in holding the flap 408 in place against the flap receiving surface 406 .
- a graft clip 412 is connected to each arm 402 .
- Each graft clip 412 may be configured to rotate relative to the corresponding arm 402 .
- each graft clip 412 is pivotally connected to the corresponding arm 402 at or near the outer edge 414 of that arm 402 .
- at least one graft clip 412 is movable relative to the corresponding arm 402 in a different way, such as by sliding.
- at least one graft clip 412 is initially a separate component from the arm 402 , and is connectable to the corresponding arm 402 .
- Each graft clip 412 is moveable between an open position and a closed position relative to the corresponding arm 402 .
- the graft clip 412 is positioned relative to the flap receiving surface 406 on the corresponding arm 402 such that, in the closed position, the graft clip 412 is configured to engage a flap 408 of the graft vessel 404 .
- the graft clip 412 may engage substantially all of the flap 408 , or less than all of the flap 408 .
- the graft clip 412 may include ridges 416 corresponding to ridges 416 extending from the flap receiving surface 406 .
- the spikes 410 alone hold the flaps 408 onto the corresponding flap receiving surfaces 406 , and one or more graft clips 412 are not used.
- the spikes 410 are oriented at an angle that facilitates the opening of the tissue effector 400 after the flaps 408 are connected to the target vessel.
- the vein knives 432 that are described below may be omitted, because the staple holder 38 is disengaged from the flaps 408 simply by removal of the spikes 410 from the flaps 408 .
- construction of the tissue effector 400 may be simplified.
- a structure or mechanism other than or in addition to the spikes 410 may be used to hold the flaps 408 onto the corresponding flap receiving surfaces 406 .
- Each graft clip 412 is locked or otherwise held in the closed position to securely hold the flap 408 between itself and the corresponding flap receiving surface 406 .
- the pressure between the graft clip 412 and the flap receiving surface 406 alone or in conjunction with ridges 416 on the graft clip 412 and the flap receiving surface 406 and/or spikes 410 extending upward from the flap receiving surface, holds the flap 408 firmly in place.
- the spikes 410 if used, may engage the graft clip 412 when it is in the closed position.
- each graft clip 412 may be shaped or configured in any manner that allows it to participate in holding the corresponding flap 408 to the corresponding flap receiving surface 406 .
- the graft clip 412 may be locked or otherwise held in the closed position with any appropriate mechanism, structure or method. As one example, the graft clip 412 uses a cam lock to hold itself in the closed position. Referring also to FIG. 59A , the graft clip 412 is in an open position. In the open position, the graft clip 412 is positioned to receive a flap 408 of the graft vessel 404 between it and the flap receiving surface 406 .
- the graft clip 412 is rotatable about an axle 418 that is spaced apart from a wall 420 defined on an arm 402 of the staple holder 38 .
- the wall 420 may be perpendicular or otherwise angled to the flap receiving surface 406 .
- the axle 418 is connected to the arm 402 , and is substantially fixed relative to the wall 420 . Alternately, the axle 418 is movable relative to the wall 420 .
- the axle 418 extends substantially longitudinally, but may be angled relative to the longitudinal direction.
- the arm 402 also includes an overhang 586 that extends outward and downward from the main portion of the arm 402 . Alternately, the overhang 586 extends in a different direction. The overhang 586 may extend laterally outward at least as far as the longitudinal centerline of the axle 418 , but need not do so.
- the graft clip 412 includes a lobe 422 in proximity to the axle 418 , where the lobe 422 has a non-circular cross section.
- the lobe 422 has a variable thickness, where thickness is defined as the distance between the surface of the axle 418 and the surface of the lobe 422 .
- the lobe 422 includes a first portion 588 that has a relatively small thickness. When the graft clip 412 is in the open position, the first portion 588 is substantially adjacent to the overhang 586 . The thickness of the first portion 588 of the lobe 422 is substantially equal to the distance between the axle 418 and the overhang 586 . Alternately, the first portion 588 of the lobe 422 may have a different thickness.
- a step 590 which may be substantially aligned with the centerline of the axle 418 .
- the graft clip 412 may be a mirror image of the clip 412 shown in FIG. 59A , such that the thickness of the lobe 422 relative to the angular position thereon is reversed from the description above. Similarly, if the graft clip 412 is viewed from the opposite direction, the thickness of the lobe 422 will be reversed from the description above. The operation of the graft clip 412 is the same.
- the first portion 588 of the lobe 422 is adjacent to the overhang 586 .
- This first portion 588 may be substantially as thick as the distance between the axle 418 and the overhang 586 .
- the portion of the lobe 422 adjacent to and immediately clockwise from the step 590 may be in contact with or in proximity to the wall 420 .
- the graft clip 412 is rotated about the axle 418 from the open position to the closed position in a clockwise direction by the user or by a mechanism associated with the tissue effector 400 . As this rotation begins, increasingly-thick portions of the lobe 422 move between the axle 418 and the overhang 586 .
- the overhang 586 , axle 418 , and/or lobe 422 may flex to accommodate the increased amount of thickness of the lobe 422 between the axle 418 and the overhang 586 . Further, this increase in thickness between the axle 418 and the overhand 586 may provide at least some resistance to the motion of the graft clip 412 .
- the step 590 encounters the overhang 586 , then moves past the overhang 586 .
- the thickness of the lobe 422 between the overhang 586 and the axle 418 decreases abruptly.
- the stiffness of the overhang 586 is such that the overhang 586 can flex enough to allow the graft clip 412 to rotate past the step 590 .
- Rotation of the graft clip 412 may stop at or shortly after the motion of the step 590 past the overhang 586 , such that the graft clip 412 stops at the closed position shown in FIG. 59C .
- step 590 acts to hold the graft clip 412 in the closed position.
- a structure or mechanism other than a cam lock may be used to hold the graft clip 412 in a closed position.
- at least one elastic band (not shown) may be used to hold the graft clip 412 against the staple holder 38 .
- Each elastic band may be fixed to either the graft clip 412 or the staple holder 38 .
- the graft clip 412 and the corresponding arm 402 may each include corresponding magnets (not shown), such that magnetic force holds the graft clip 412 in contact with the arm 402 in the closed position.
- a snap arm 606 may be used to hold the graft clip 412 in a closed position.
- the snap arm 606 is connected at one end to the corresponding arm 402 .
- This connection may be a hinge, or may be any other connection that allows the snap arm 606 to move between an open position, in which the graft clip 412 may be opened, and a closed position, in which the graft clip 412 is held closed.
- the connection between the proximal end of the snap arm 606 and the arm 402 is made proximal to the flap receiving surface 406 .
- the connection between the snap arm 606 and the staple holder 38 is made at a different location.
- a different part of the snap arm 606 than its proximal end is connected to the arm 402 .
- the distal end of the snap arm 606 includes a catch 608 that is shaped to engage the distal end of the corresponding arm 402 .
- the catch 608 may be curved such that a lobe 610 of the catch 608 is proximal to the distal end of the arm 402 when the snap arm 606 is in the closed position, thereby holding the snap arm 606 , and the graft clip 412 , in place.
- the catch 608 is at least partially flexible such that the catch 608 can be snapped down onto the distal end of the corresponding arm, thereby holding the snap arm 606 in the closed position.
- the catch 608 may be configured differently, if desired.
- the snap arm 606 When the snap arm 606 is in the closed position, at least a portion of the graft clip 412 is positioned between the snap arm 606 and the corresponding arm 402 . Thus, in the closed position, the snap arm 606 presses the graft clip 412 against the arm 402 , holding it in place. As a result, the graft clip 412 holds the corresponding flap 408 against the flap receiving surface 406 .
- a separate snap arm 606 is not used, and the graft clip 412 itself includes a catch 608 that engages the corresponding arm 402 of the tissue effector 400 .
- the snap arm 606 , or the graft clip 412 that includes a catch 608 is oriented differently, such as described above with regard to FIGS. 59A-59B .
- each graft clip 412 in the closed position, is configured to press a flap 408 of the target vessel against the corresponding flap receiving surface 406 .
- the flap 408 is not shown for clarity.
- the graft clip 412 and the flap receiving surface 406 are substantially fixed relative to one another.
- the graft clip 412 and the corresponding flap receiving surface 406 may be configured such that a portion of each would contact the other in the closed position, absent the flap 408 .
- the graft clip 412 compresses the flap 408 against the flap receiving surface 406 .
- the graft clip 412 may include an overhang 424 , which extends along at least a portion of the edge of the graft clip 412 .
- the overhang 424 may be substantially parallel to and in proximity to the corresponding inner edge 411 of the arm 402 in the closed position. Alternately, the overhang 424 may be configured differently relative to the arm 402 .
- the overhang 402 may bend the flap 408 and/or press, pinch or otherwise hold it against the corresponding edge of the arm 402 .
- a first channel 426 may be defined in the graft clip 412
- a corresponding second channel 428 may be defined in the arm 402 .
- the first channel 426 and the second channel 428 are substantially linear and substantially aligned with one another. Alternately, the first channel 426 and the second channel 428 are configured differently, aligned differently with respect to one another and/or have a different cross-section.
- Each channel 426 , 428 is open along one side, at least in part.
- the first channel 426 and the second channel 428 are oriented and aligned relative to one another such that the openings in the channels 426 , 428 face one another to form a vein knife passage 430 .
- the channels 426 , 428 may be spaced apart from one another at least in part and still form the vein knife passage 430 ; that is, the vein knife passage 430 need not be bounded around its entire periphery. Alternately, the channels 426 , 428 are oriented and aligned differently, and/or the vein knife passage 430 is formed differently. Each vein knife passage 430 is oriented such that, when the tissue effector 40 is in the closed position, the longitudinal centerline of the vein knife passage 430 is substantially parallel to the longitudinal axis of the anvil 10 . Alternately, the vein knife passages 430 are aligned differently relative to the longitudinal axis of the anvil 10 when the tissue effector 400 is in the closed position.
- At least one vein knife passage 430 is configured to receive a corresponding vein knife 432 .
- the fit between the dimensions of the vein knife 432 and the corresponding vein knife passage 430 is close enough that the vein knife passage 430 guides the vein knife 432 and substantially prevents wobbling or other disruption of the motion of the vein knife 432 as it travels along the vein knife passage 430 , and loose enough to allow the vein knife 432 to slide easily along that vein knife passage 430 substantially without binding or interference.
- Each vein knife 432 has a blade 434 or other sharp element at its distal end.
- the blade 434 of at least one vein knife 432 may be angled. Alternately, the blade 434 of at least one vein knife may be curved or otherwise shaped.
- each vein knife 432 is connected to a sled, which is described in greater detail below.
- the vein knife 432 is configured to translate or otherwise move between a first position and a second position. In the first position, the blade 434 of the vein knife 432 is located proximal to the flap 408 held between the graft clip 412 and the flap receiving surface 406 . The vein knife 432 translates or otherwise moves to the second position and cuts the flap 408 as it does so. In the second position, the blade 434 of the vein knife 432 is located adjacent or distal to the portion of the flap 408 held between the graft clip 412 and the flap receiving surface 406 . The first and second positions are reversed when the vein knife 432 is moved in the opposite direction.
- one or more graft clip blades 436 are connected to at least one graft clip 412 .
- one or more of the graft clip blades 436 may be serrated.
- Each graft clip blade 436 is located in and against one side of the first channel 426 , such that it does not interfere with the motion of the vein knife 432 .
- one or more graft clip blades 436 are located in a different position on the corresponding graft clip 412 or arm 402 .
- Serrations 438 on the graft clip blade 436 are oriented toward the open face of the first channel 426 in the graft clip 412 .
- the serrations 438 may be sized and shaped in any appropriate manner.
- the serrations 438 assist in holding the flap 408 between the graft clip 412 and the flap receiving surface 406 . That is, one or more of the serrations 438 may penetrate into or through the flap 408 , thereby holding the tissue of the flap 408 substantially fixed relative to the graft clip 412 and the flap receiving surface 406 .
- the serrations 438 hold the flap 408 .
- the motion of the vein knife 432 may apply stress to the tissue of the flap 408 such that the serrations 438 themselves act to cut the tissue of the flap 408 .
- the cutting action may be a scissors-like action resulting from the relative motion of the vein knife 432 and the graft clip blade 436 .
- More than one graft clip blade 436 can be provided in at least one vein knife passage 430 .
- two graft clip blades 436 may be located in one first channel 426 , in and against two different sides of the first channel 426 and spaced apart from one another a sufficient distance to allow the vein knife 432 to slide therebetween.
- Other configurations or numbers of graft clip blades 436 may be utilized, if desired.
- At least one graft clip 412 may have a thinner cross-section than the graft clip 412 of FIGS. 59-59B .
- This thinner cross-section may be achieved by utilizing metal, such as sheet metal, to form at least part of the graft clip 412 .
- metal need not be used in order for the graft clip 412 to be made thinner.
- the graft clip 412 may be an assembly having a first piece 407 connected to a second piece 409 . The first piece 407 is located at or near the first channel 426 of the graft clip 412 .
- the graft clip 412 may be a single-piece, or may be an assembly having additional components.
- the second piece 409 may be made of plastic or any other suitable material. Other materials may be used to form the pieces 407 , 409 if desired.
- the graft clip blades 436 may be formed into the first piece 407 , particularly where at least the first piece 407 of the graft clip 412 is metal. By forming the graft clip blades 436 into a portion of the graft clip 412 rather than connecting them to the graft clip 412 , construction of the graft clip 412 may be simplified.
- a thinner graft clip 412 results in less compression of the surface of the heart, where the target vessel is a coronary artery and the anvil arm 14 is inserted into that coronary artery.
- the vertical distance between the bottom of the anvil arm 14 and the bottom of the graft clip 412 substantially defines the distance across which the heart tissue near the coronary artery is compressed as the tissue effector 400 moves from the open to the closed position.
- the heart tissue around the coronary artery is compressed a lesser distance.
- the amount of force required to move the tissue effector 400 from an open position to a closed position, in which compressive force is applied against the heart tissue may be decreased. This reduction in force may simplify the construction of the tissue effector 400 .
- a passage 440 is defined within each arm 402 .
- Each passage 440 extends substantially longitudinally within the corresponding arm 402 , and the longitudinal centerline of each passage 440 is substantially parallel to the longitudinal centerline of the anvil 10 when the tissue effector 400 is in the closed position. Alternately, at least one passage 440 is oriented differently relative to its corresponding arm 402 .
- the passage 440 may have a rectangular cross-section, or a different cross-section. Further, the dimensions of the passage 440 may be substantially constant along its entire length, or may change along at least part of its length.
- the distal end 442 of the passage 440 is open, and/or the proximal end 444 of the passage 440 is open.
- a ramp element 446 is configured to translate or otherwise move through at least a portion of each passage 440 .
- the ramp elements 446 may be molded or otherwise formed into a unitary ramp element assembly 484 , or may be molded or otherwise formed separately and then connected together.
- the ramp elements 446 may be formed from stainless steel or other appropriate material.
- the vein knives 432 are connected to the ramp element assembly 484 to form a sled 482 .
- apertures 486 are defined in the ramp element assembly 484 , and the proximal end of each vein knife 432 is sized and shaped to provide for a pressure or interference fit within the corresponding aperture 486 .
- each vein knife 432 may be connected to the ramp element assembly 484 .
- the ramp elements 446 and the vein knives 432 are cast, molded or otherwise formed as a single unit.
- the vein knives 432 are fixed to the ramp element assembly 484 , such that the ramp elements 446 and the vein knives 432 translate as a unit substantially simultaneously.
- at least one ramp element 446 is moveable relative to at least one vein knife 432 .
- each ramp element 446 is connected to the corresponding vein knife 432 , but the ramp elements 446 are not connected to one another.
- the sled 482 includes an attachment feature 488 .
- the attachment feature 488 may be an aperture through a portion of the ramp element assembly 484 that is configured to receive a second cable 490 or other force transmission mechanism or structure. Where a cable is used and the attachment feature 488 is an aperture, the second cable 490 may be inserted into and/or through the attachment feature 488 , and held in place there such as by tying off one end of the cable, by welding, by adhesive, or any other appropriate connection method.
- the attachment feature 488 may be a ring, a hook, a raised area, a depression, or any other structure or mechanism appropriate for connection to a cable or other force transmission mechanism or structure.
- One or more connector bays 448 are defined in each arm 402 , between the passage 440 within the arm 402 and an inner surface 450 of the arm 402 .
- the connector bays 448 and the passages 440 are substantially hollow.
- the cross-sectional shape of each connector bay 448 is selected to allow it to receive and hold a staple, as described below.
- the connector bays 448 are oriented such that the longitudinal centerline of each connector bay 448 is substantially perpendicular to the longitudinal centerline of the corresponding passage 440 . Alternately, at least one connector bay 448 is oriented differently relative to the corresponding passage 440 .
- Each connector bay 448 has substantially the same cross-section and length.
- At least one connector bay 448 has a different cross-section and/or length than at least one other connector bay 448 .
- the connector bays 448 may be oriented relative to a local horizontal such that the longitudinal centerline of each connector bay 448 forms an angle of between 0° and 45° relative to that local horizontal.
- a different orientation may be used, if desired.
- the use of the term “horizontal” here and elsewhere in this document is used for convenience in description only, and does not restrict the orientation in which the anastomosis tool 300 may be used.
- At least one connector bay 448 is configured to receive a connector deployer 452 .
- Each connector bay 448 is shaped to allow the corresponding connector deployer 452 to translate or otherwise move within it.
- the sliders 452 may be shaped in any appropriate manner.
- a connector deployer 452 is substantially curved at its outer end 454 and substantially flat at its inner end 456 .
- the connector deployer 452 may vary in height along at least a portion of its length and/or width.
- a registration element 458 may extend upward from the upper surface 460 of the connector deployer 452 .
- the registration element 458 may be formed into the connector deployer 452 , or otherwise manufactured into it or connected to it.
- the corresponding connector bay 448 is shaped accordingly. That is, the size, shape and orientation of the registration element 458 of the connector deployer 452 corresponds to the size, shape and orientation of a registration feature 462 of the connector bay 448 .
- the corresponding connector bay 448 is shaped as shown in FIG. 66 .
- the registration element 458 translates along the registration feature 462 as the connector deployer 452 translates along the connector bay 448 . In this way, the connector deployer 452 is maintained in a desired orientation throughout its translation relative to the connector bay 448 , and the connector deployer 452 is prevented from cocking in the connector bay 448 during that translation.
- the sliders 452 and corresponding connector bays 448 may be shaped differently, if desired.
- the sliders 452 are all shaped substantially identically.
- at least one of the sliders 452 is shaped differently from at least one of the others, and the corresponding connector bay or bays 448 are shaped accordingly.
- a biocompatible lubricant such as sodium stearate may be used between at least one connector deployer 452 and the corresponding connector bay 448 to facilitate the translation of the connector deployer 452 relative to the connector bay 448 .
- Each connector deployer 452 is moveable between a first position and a second position. In the first position, the outer end 454 of the connector deployer 452 extends at least partially into the passage 440 . Alternately, the outer end of the connector deployer 452 does not extend into the passage 440 . In the second position, the connector deployer 452 has translated relative to the corresponding connector bay 448 and completed its motion. The outer end 454 of the connector deployer 452 no longer extends into the passage 440 . Alternately, the outer end 454 of the connector deployer 452 still extends into the passage 440 in the second position. Each connector deployer 452 translates or otherwise moves from the first position to the second position as a result of contact with the ramp element 446 . This translation is described in greater detail below.
- a connector 464 is placed in at least one connector bay 448 .
- the connector 464 is a staple.
- Each connector 464 is located closer to the inner surface 450 of the arm 402 than the corresponding connector deployer 452 .
- the connector 464 may be configured as disclosed in pending U.S. patent application Ser. No. 10/309,519 filed on Dec. 4, 2002, which is hereby incorporated by reference in its entirety.
- the connector 464 includes four tines 466 extending from a base 468 .
- the tines 466 may be offset from one another.
- a different configuration of connector 464 may be used, if desired.
- the connector 464 is constructed from 316L stainless steel, but may be constructed from a different type of stainless steel, or from a different material.
- the connector 464 may be a connector other than a staple, such as a pin or clip.
- Each connector 464 is oriented in the connector bay 448 such that the tines 466 extend in a direction facing substantially out of the connector bay 448 .
- each connector 464 is oriented differently.
- the base 468 of the connector 464 may be in contact with the inner end of the corresponding connector deployer 452 when that connector deployer 452 is in the first position, or may be spaced apart from the inner end of that connector deployer 452 in the first position.
- the corresponding connector 464 is held within the connector bay 448 in any appropriate way.
- the tines 466 of each connector 464 may be biased against at least part of the corresponding connector bay 448 .
- At least one tine 468 may be biased against a lower surface 470 of the connector bay 448 and at least one other tine 469 may be biased against an upper surface 472 of the connector bay 448 .
- the biasing force exerted by each tine 468 against the corresponding surface 470 , 472 of the connector bay 448 holds the connector 464 in place when the connector deployer 452 is in the first position.
- the biasing forces exerted by the tines 468 are high enough to hold the connector 464 securely within the connector bay 448 , and are low enough to allow the connector 464 to translate easily as a result of contact with the corresponding connector deployer 452 .
- each connector 464 may be held in place in the corresponding connector bay 448 with a biocompatible substance that provides friction between that connector 464 and the connector bay 448 , where the amount of force required to overcome that friction and move the connector 464 is selected to be less than the amount of deployment force to be exerted on the connector 464 by the corresponding connector deployer 452 .
- the translation of a connector deployer 452 from the first position to the second position causes deployment of the corresponding connector 464 , as described in greater detail below.
- the ramp element 446 translates or otherwise moves within the passage 440 , as described above.
- the distal end 474 of the ramp element 446 is configured to engage the sliders 452 as it moves, causing those sliders 452 in turn to translate or otherwise move relative to their respective connector bays 448 .
- the ramp element 446 is curved and/or angled at its distal end 474 , where the curvature and/or angularity begins at or near the most distal point of the ramp element 446 and continues proximally along the inner surface 476 of the ramp element 446 . That is, the ramp element 446 increases in width from its most distal point to a selected point spaced apart from and proximal to that most distal point.
- the ramp element 446 may be shaped such that the curvature and/or angularity of the distal end 474 is present on the inner surface 476 of the ramp element 446 , and such that the outer surface 478 of the ramp element 446 is substantially flat against a wall of the passage 440 .
- the ramp element 446 may be shaped in any other appropriate manner.
- the ramp element 446 may be translated distally along at least a portion of the passage 440 . In the course of this translation, the distal end 474 of the ramp element 446 sequentially contacts and thereby actuates the sliders 452 , beginning with the most proximal and concluding with the most distal.
- the ramp element 446 translates proximally to contact and actuate sequentially the sliders 452 , beginning with the most distal and concluding with the most proximal.
- the ramp element 446 is configured to move in such a manner that at least a component of its motion is toward the inner surface 450 of the arm 402 , such that the ramp element 446 engages more than one connector deployer 452 at a time.
- the ramp element 446 , another component of the sled 482 , or a different component may actuate the sliders 452 serially or in parallel.
- one or more of the sliders 452 are omitted from the tissue effector 400 , such that the ramp element 446 and/or a different component of the sled 482 directly contacts one or more of the staples 464 to urge that staple or staples 464 out of the corresponding arm 402 . That is, the intermediate mechanism between the sled 482 and at least one of the staples 464 may be omitted. If so, the sled 482 and/or at least one connector 464 are configured such that contact between them urges the connector 464 in the desired direction.
- one or more of the staples 464 may include a structure analogous to the connector deployer 452 formed into it, where that structure is implanted into the patient along with the connector 464 .
- This additional structure is small, and is positioned outside the lumen of both the graft vessel and the target vessel, such that its presence in the patient has no effect.
- a structure may be composed of stainless steel or other biocompatible material, or from bioabsorbable material that is gradually absorbed by the patient. Such biocompatible and bioabsorbable materials are standard in the art.
- one or more of the connector bays 448 may be omitted from one or more of the arms 402 of the tissue effector 400 .
- the staples 464 may be connected to the sled 482 or other component such as by adhesive, where that connection is able to withstand an amount of force less than the force with which the deployed connector 464 grips the graft vessel 404 and the target vessel 580 .
- the anvil 10 is connected to a force transmission mechanism such as a first cable 480 .
- the anvil 10 may include a cutter stop 236 having one or more attachment features 270 to which the first cable 480 is connected.
- the first cable 480 may be connected to a different or an additional part of the anvil 10 .
- the sled 482 is connected to a force transmission mechanism such as a second cable 490 .
- a force transmission mechanism such as a second cable 490 .
- the sled 482 includes an attachment feature 488 to which the second cable 490 is connected.
- the second cable 490 may be connected to a different or an additional part of the sled 482 .
- one or both of the cables 480 , 490 are not used, and a different force transmission mechanism is used instead.
- one or both force transmission mechanisms may be a chain, a shaft, one or more gears, one or more tubes for handling pressurized gas or vacuum, conductive elements for carrying electricity, and/or other appropriate mechanisms.
- the cables 480 , 490 extend proximally from the tissue effector 400 .
- a cable housing 306 is provided.
- the cable housing 306 is a tube that is at least partially flexible, through which at least a portion of the cables 480 , 490 extend. Two or more lumens or passages may be present in the cable housing 306 , such that each cable 480 , 490 extends through a different lumen or passage.
- the staple holder 38 includes a collar 492 .
- the collar 492 may be formed into the staple holder 38 , or formed separately from and attached to the staple holder 38 .
- the collar 492 includes a passage 494 therethrough.
- the diameter of the passage 494 may be substantially the same as the outer diameter of the cable housing 306 , such that the distal end of the cable housing 306 may be received into and/or through the collar 492 and held therein.
- the shape of the passage 494 may substantially correspond to the shape of the distal end of the cable housing 306 .
- the distal end of the cable housing 306 is fixed to the collar 492 via a friction fit, adhesive, welding, or any other appropriate structure, mechanism or method.
- the cable housing 306 need not have a uniform shape, size or cross-section along its entire length. Alternately, the distal end of the cable housing 306 may connect to a different portion of the tissue effector 400 , or may not connect to the tissue effector 400 at all. Additionally, the cable housing 306 may pass over and/or connect to one or more of the connection members 280 of the tissue effector 400 , and/or one or more other components of the tissue effector 400 .
- One or more channels 496 may be defined on the surface of the staple holder 38 distal to the collar 492 . Each channel 496 receives a cable 480 , 490 . At least one channel 496 may be curved in a convex manner, such that the corresponding cable 480 , 490 curves as well. The convex curvature causes the most distal part of that channel 496 to be located between the upper and lower ends of the channel 496 .
- the cable 480 , 490 in that channel 496 may be under tension, such that it follows the curvature of that channel 496 .
- the channel 496 causes the cable 480 , 490 received therein to curve back in a proximal direction.
- the second cable 490 is connected to the sled 482 . Tension on the second cable 490 that results from proximal motion of its proximal end also results in distal motion of the sled 482 .
- the shaft 304 may be bifurcated at its distal end, forming two spaced-apart arms 305 .
- the cable housing 306 passes between the arms 305 , such that the arms 305 constrain the potential lateral motion of the cable housing 306 . Alternately, the cable housing 306 does not pass between the arms 305 .
- At least one arm 305 forms or connects to a paddle 307 at its distal end.
- the cable housing 306 extends in a curved configuration, such as an S-shaped or serpentine configuration, between the shaft 304 and the tissue effector 400 .
- the paddle or paddles 307 may be substantially planar and parallel to one another.
- a receiving opening 309 is provided through at least one paddle 307 , each opening corresponding to a cog 282 of the tissue effector 400 .
- One or more detents 310 are present along the perimeter of the receiving opening 309 , corresponding to the teeth 284 of the cog 282 .
- the teeth 284 are configured to engage the detents 310 in the receiving opening 309 .
- the button 278 connected to the cog 282 may be connected to the spine 272 with a single connection member 280 spaced apart from the cog 282 , or may be connected to the spine 272 with one or more flexible connection members 280 . As a result, the buttons 278 can be compressed together, such that the teeth 284 are moved out of engagement with the corresponding detents 310 .
- the cog 282 thus can be moved to a position out of contact with the receiving opening 309 , such that it is located between the paddles 307 . Consequently, the cog 282 and the tissue effector 400 can be freely rotated to a desired orientation.
- the buttons 278 are then released, such that the cog 282 re-enters the receiving opening 309 and the teeth 284 engage the detents 310 in the receiving opening 309 once again.
- the cog 282 engages a corresponding gear or other structure or mechanism in or on the shaft 304 , such that motion of the corresponding gear rotates the cog 282 .
- the cog 282 is connected to the shaft 304 or one or more components in and/or on the shaft 304 in such a way that the cog 282 can be rotated or otherwise manipulated as desired.
- the tissue effector 38 is connected to the shaft 304 with a mechanism or structure other than or in addition to the cog 282 .
- the cog 282 allows the tissue effector 38 to be oriented at a plurality of positions relative to the shaft 304 . That is, the cog 282 allows the tissue effector 38 to move such that the longitudinal centerline of the tissue effector 38 may be positioned at more than one angle relative to the longitudinal centerline of the shaft 304 .
- the cog 282 or other mechanism may allow the tissue effector 38 to move smoothly through a range of orientations relative to the handle 302 , or may allow the tissue effector 38 to move among two or more discrete orientations relative to the handle 302 . Thus, the tissue effector 38 is orientable to two or more different positions relative to the handle 302 .
- the relative motion between the tissue effector 38 and the shaft 304 allows the tissue effector 38 to be utilized on target vessels having a number of different orientations within the patient, while allowing convenient access by the surgeon or other medical professional. That is, the surgeon may hold the handle 302 in a single convenient position, and orient the tissue effector 38 into a selected position relative to the shaft 304 and handle 302 that is optimal for use with a particular target vessel.
- the arms 305 or a mechanism connected to the arms may be capable of rotation relative to the shaft 304 , providing additional freedom of motion for the tissue effector 38 .
- the cog 282 is not present, and the arms 305 otherwise allow motion of the tissue effector 38 relative to the shaft 304 .
- the tissue effector 400 is fixed relative to the shaft 304 .
- the shaft 304 is substantially hollow along at least part of its length, starting at its proximal end and continuing distally.
- the entire shaft 304 may be substantially hollow.
- An aperture 498 or other opening is located in the wall of the shaft 304 at a point along its length where it is hollow.
- the aperture 498 provides access to the lumen of the shaft 304 .
- the cable housing 306 extends through the aperture 498 into the lumen of the shaft 304 .
- the cable housing 306 does not enter the lumen of the shaft 304 , and instead is attached to the outer surface of the shaft 304 with adhesive, clips, pins, and/or any other appropriate attachment mechanisms, structures or methods. If so, the shaft 304 need not include a lumen.
- the cable housing 306 does not connect to the shaft 304 at all, and instead connects to the handle 302 directly. If so, the shaft 304 need not include a lumen, and may be solid.
- the proximal end of the shaft 304 is connected to the handle 302 .
- the handle 302 may be formed from two or more individual handle shell members 502 that are connected to one another. Alternately, the handle 302 may be constructed differently.
- the shaft 304 may be fixed to the handle 302 such that it does not substantially move relative to the handle 302 .
- a member 500 extends from one handle shell member 502 into the hollow interior of the handle 302 . That member 500 may connect at its other end to the other handle shell member 502 .
- the proximal end of the shaft 304 includes a corresponding aperture 504 , such that the member 500 fits within the aperture 504 .
- the aperture 504 is substantially the same size as the cross-section of the member 500 .
- the member 500 engages the aperture 504 of the shaft 304 and holds the shaft 304 in place.
- a member 500 extends from each handle shell member 502 , and those members 500 both engage the aperture 504 of the shaft 304 .
- ribs may be defined in the inner surface of the handle, and a corresponding retainer (not shown) is defined at or near the proximal end of the shaft.
- the retainer is wider than the shaft 304 , and has a selected thickness. The ribs are spaced apart from one another substantially the same distance as the thickness of the retainer.
- the ribs thus substantially prevent the shaft 304 from translating proximally or distally.
- the handle 302 may engage the retainer with a registration feature or other structure or mechanism to substantially prevent rotation of the shaft 304 about its longitudinal axis. Alternately, the handle 302 holds the shaft 304 in a different way.
- the handle 302 has a substantially hollow interior. Where the shaft 304 includes a lumen, the lumen of the shaft 304 opens into the interior of the handle 302 .
- the cables 480 , 490 extend out of the lumen of the shaft 304 into the hollow interior of the handle 302 . Alternately, the cables 480 , 490 extend through the cable housing 306 directly into the handle 302 , bypassing the shaft 304 .
- mechanisms within the handle 302 are utilized to actuate the tissue effector 38 via the cables 480 , 490 . Alternately, at least some of those mechanisms are separate from the handle 302 .
- a single input to the anastomosis tool 300 via the trigger 308 actuates the anastomosis tool 300 . Alternately, one or more additional inputs to the anastomosis tool 300 are required, such as actuation of a safety switch or depression of a second feature.
- the trigger 308 initially extends outward from the upper surface of the handle 302 through an aperture 506 in the handle 302 . Alternately, the trigger 308 initially extends from a different surface of the handle 302 .
- the trigger 308 is initially flush with the surface of the handle 302 , or otherwise configured.
- the handle 302 may be shaped ergonomically for ease of operation.
- the handle 302 is curved and tapered slightly toward its proximal end, and substantially bilaterally symmetrical, such that the proximal end of the handle 302 can be gripped easily with either the left or the right hand.
- the handle 302 may be ergonomically configured in a different way for ease of actuation by the user.
- the trigger 308 is positioned on the handle 302 such that it can be actuated conveniently by a user's thumb.
- the trigger 308 could be placed on the underside of the handle 302 for actuation with the index finger of either hand. More than one finger may be used to actuate the trigger 308 and/or other mechanisms for actuating the anastomosis tool 300 .
- the trigger 308 is connected to a rocker 508 .
- the trigger 308 may be formed into the rocker 508 , or otherwise connected to it.
- the rocker 508 is located inside the handle 302 . Alternately, the rocker 508 is located at least partly outside the handle 302 .
- the rocker 508 is rotatably mounted to a rocker axle 510 .
- the rocker axle 510 extends from one interior surface of the handle 302 , and may extend to a different interior surface of the handle 302 to provide additional stiffness and/or stability to the rocker axle 510 . Alternately, the rocker axle 510 may connect to the handle 302 in a different way.
- the rocker 508 includes a proximal arm 514 extending proximally to the rocker axle 510 .
- the proximal arm 514 may be formed into the rocker 508 , or otherwise connected to it.
- the proximal end 516 of the proximal arm 514 may be tapered to a curved or rounded surface. Alternately, the proximal end 516 of the proximal arm 514 is shaped differently. Alternately, the entire proximal arm 514 is tapered.
- the rocker axle 510 is located proximal to the trigger 308 . As a result, depression of the trigger 308 causes rotation of the rocker 508 such that the proximal end 516 of the proximal arm 514 moves upward.
- the rocker 508 also includes a distal arm 518 extending distal to the trigger 308 , where the distal arm 518 has a distal end 520 .
- the distal arm 518 may be formed into the rocker 508 , or otherwise connected to it. Referring also to FIG. 71 , at least a portion of the distal arm 518 may be bifurcated into two or more spaced-apart members 542 .
- a post 544 may be located at the distal end of each member 542 . At least one post 544 substantially may take the shape of a cylindrical or rectangular solid.
- Each post 544 is angled relative to the corresponding member 542 , protruding at least partly inward. This angle may be substantially ninety degrees, or any other angle. Alternately, at least one post 544 extends outward from the corresponding member. The posts 544 are spaced apart from one another by a distance that is less than the distance separating the spaced-apart members 542 . Alternately, at least one post 544 is located at a position on the corresponding member 542 other than its distal end. As one example, at least one post 544 may be positioned a short distance proximal to the distal end of the corresponding member 542 .
- rocker axle 510 is located proximal to the trigger 308 , depression of the trigger 308 causes the distal end 520 of the distal arm 518 to move downward.
- the arms 514 , 518 of the rocker 508 are configured to move in another manner when the trigger 308 is depressed.
- the rocker 508 may be shaped or configured differently than described above.
- a proximal slider 522 is also included within the handle 302 .
- the proximal slider 522 includes at least one flange 524 extending laterally from at least one side thereof.
- a flange 524 extends from each side of the proximal slider 522 for stability. Additional flanges 524 may be provided, if desired.
- Ribs 526 are molded, formed, connected or otherwise attached to the inner surface of the handle 302 . Two ribs 526 are spaced apart from one another a distance substantially equal to the thickness of the corresponding flange 524 , such that each flange 524 is configured to slide therebetween. Each pair of ribs 526 substantially constrains the motion of the corresponding flange 524 .
- a spring 546 is connected at one end to the handle 302 , and is connected to or engages the proximal slider 522 .
- the spring 546 is in compression, and thereby biases the proximal slider 522 distally.
- a stop 547 may be connected to or defined in the inner surface of one or more of the handle shell members 502 , where the stop or stops 547 are located distal to the proximal slider 522 .
- the stop or stops 547 act to restrain the distal motion of the proximal slider 522 , thereby defining a position that is the most distal the proximal slider 522 can travel.
- a different or additional mechanism, structure or method may be used to bias the proximal slider 522 distally.
- the spring 546 is initially neither in tension nor compression, but is compressed by the rocker 508 during at least a portion of its travel.
- the spring 546 stores energy within itself when it is in tension.
- an energy storage device could be used in lieu of the spring 546 .
- the energy storage device is a reservoir or cylinder of pressurized gas. Valves, tubing and/or other structure may be used to route the pressurized gas to desired locations in the handle 302 such that the energy stored in the gas is used to bias the proximal slider 522 distally, and/or to perform other actuation functions within the handle 302 and/or the tool 300 .
- the gas may be carbon dioxide, nitrogen, a different gas, air, or a combination of gases.
- a cylinder or source of vacuum may be used as an energy storage device.
- Valves, tubing and/or other structure may be used to route the vacuum to desired locations in the handle 302 such that the vacuum can be used to bias the proximal slider 522 distally, and/or to perform other actuation functions within the handle 302 and/or the tool 300 . That is, compressed gas may be used for controlling the operation of the tool 300 instead of or in addition to providing energy storage.
- a battery may be used as an energy storage device. Wiring and actuators such as solenoids or motors may be provided within the handle 302 such that the stored electrical energy in the battery is used to bias or hold the proximal slider 522 distally, and/or to perform other actuation functions within the handle 302 and/or the tool 300 .
- electromagnetic energy may be used for controlling the operation of the tool 300 instead of or in addition to providing energy storage.
- the trigger 308 may be configured differently, such that actuation of the anastomosis tool 300 may be performed simply by contacting the trigger 308 with a finger, or moving the trigger 308 through a more limited range of motion. Alternately, the trigger 308 may be omitted altogether, and the anastomosis tool 300 may be actuated remotely by a computer, dedicated control station, handheld computing device, or other device.
- a contact feature 528 is defined on the distal surface of the proximal slider 522 .
- the contact feature 528 is a separate element connected to the proximal slider 522 .
- the contact feature 528 is configured to engage the proximal end 516 of the proximal arm 514 at or after the time the trigger 308 is depressed, as described in greater detail below.
- the contact feature 528 is angled proximally and downward along a lower portion 530 thereof, and is substantially vertical along an upper portion 532 thereof. Alternately, the contact feature 528 is shaped and/or angled differently.
- the first cable or cables 480 are connected to the proximal slider 522 in any appropriate way.
- at least one aperture or port (not shown) may be formed in the proximal slider 522 , and at least one cable 480 is inserted into at least one aperture and secured thereto.
- an end of the cable or cables 480 may be wound around all of or a portion of, crimped to, welded to, or secured by adhesive to the proximal slider 522 .
- the proximal arm 514 of the rocker 508 may be bifurcated to allow the first cable or cables 480 to extend substantially along the longitudinal centerline of the handle 302 and between the bifurcations substantially without interference.
- the lower portion 530 of the contact feature 528 may be bifurcated as well. Where both the proximal arm 514 and the contact feature 528 are bifurcated, the two are aligned such that they contact one another during at least a portion of the travel of the rocker 508 .
- a distal slider 534 is also included within the handle 302 .
- the distal slider 534 includes a flange 536 extending outward from at least one side thereof.
- a flange 536 extends from each side of the distal slider 534 for stability. Additional flanges 536 may be provided, if desired.
- Ribs 538 are molded, formed, connected or otherwise attached to the inner surface of the handle 302 . Two ribs 538 are spaced apart from one another a distance substantially equal to the thickness of the corresponding flange 536 , such that each flange 536 is configured to slide therebetween. Each pair of ribs 538 substantially constrains the motion of the corresponding flange 536 . Where the ribs 538 are substantially linear, and ribs 538 and corresponding flanges 536 are utilized on opposite sides of the distal slider 534 , the ribs 538 substantially linearly constrain the motion of the corresponding flange 524 .
- a contact surface 548 is defined on at least a portion of the proximal surface of the distal slider 534 .
- the contact surface 548 may be curved or angled. As one example, the contact surface 548 has a concave curvature. Other shapes or configurations of the contact surface 548 may be utilized. Alternately, the contact surface 548 is located on a portion of the distal slider 534 other than its proximal surface.
- the distal slider 534 may include a passage 550 through it to allow the cables 480 , 490 to pass therethrough. Alternately, the passage 550 is not provided in the distal slider 534 , and the distal slider 534 is bifurcated or otherwise shaped to allow the cables 480 , 490 to pass through it. Alternately, the cables 480 , 490 are routed through the handle in such a way as to bypass the distal slider 534 altogether.
- the distal slider 534 may include a lower guide 552 .
- the lower guide 552 extends downward from the remainder of the distal slider 534 , and may extend proximal to the contact surface 548 . Further, the lower guide 552 may be thinner than the remainder of the distal slider 534 . Alternately, the lower guide 552 is not included in the distal slider 534 , or may be configured differently relative to the remainder of the distal slider 534 .
- the lower guide 552 may include a flange 554 extending outward from at least one side thereof.
- a flange 554 extends from each side of the lower guide 552 for stability. Additional flanges 554 may be provided, if desired.
- Ribs 556 are molded, formed, connected or otherwise attached to the inner surface of the handle 302 . Two ribs 556 are spaced apart from one another a distance substantially equal to the thickness of the corresponding flange 554 , such that each flange 554 is configured to slide therebetween. Each pair of ribs 556 substantially constrains the motion of the corresponding flange 554 . Where the ribs 556 are substantially linear, and ribs 556 and corresponding flanges 554 are utilized on opposite sides of the distal slider 534 , the ribs 556 substantially linearly constrain the motion of the corresponding flange 554 .
- a spring 540 is connected at one end to the distal slider 534 and at the other end to the handle 302 .
- An aperture 558 may be provided in the lower guide 552 , or in another part of the distal slider 534 .
- One end of the spring 540 includes a hook or similar structure, which is received into and held by the aperture 558 .
- the spring 540 is connected to the distal slider 534 in a different way. The spring 540 is in tension, and thereby biases the distal slider 534 proximally. Alternately, a different or additional mechanism, structure or method may be used to bias the distal slider 534 proximally.
- a holder 594 is connected to the inner surface of the handle 302 .
- This connection may be accomplished in any appropriate manner.
- a slot 602 may be defined in a member 604 or between two separate members 604 extending inward from the inner surface of each shell member 502 , wherein a portion of the holder 594 is held by the slot 602 such as by a pressure fit.
- the distal end 595 of the holder 594 is held by the slot 602 such that it does not substantially move.
- a different part of the holder 594 is held by the slot 602 , and/or the distal end 595 of the holder 594 is free to move.
- the holder 594 is bifurcated by an opening 598 that extends substantially longitudinally.
- Two spaced-apart members 600 extend substantially proximally, each member 600 on an opposite side of the opening 598 .
- At least the members 600 of the holder 594 have some flexibility, such that the members 600 can move up or down in response to force applied to them. However, the members 600 are stiff enough to remain in a neutral position until that force is applied.
- a stop 596 extends upward from each member 600 .
- the stops 596 are positioned and shaped to engage the bottom edge 570 of the contact surface 548 of the distal slider 534 .
- the holder 594 is substantially restrained against longitudinal motion by its engagement with the slots 602 in the shell members 502 ad/or members 604 defined in or on the shell members 502 .
- the stops 596 substantially restrain the distal slider 534 against proximal motion under the influence of the spring 540 .
- the stops 596 are stiff enough, and extend upward enough, to provide this restraint.
- the stops 596 may be curved to match the curvature of the contact surface 548 , such that they contact a portion of the contact surface.
- contact between the distal slider 534 and the rocker 508 prevents the distal slider 534 from substantially moving proximally. This contact occurs between the contact surface 548 of the distal slider 534 and the distal tip 520 of the distal arm 518 of the rocker 508 . Alternately, this contact occurs between other or additional components of the distal slider 534 and/or the rocker 508 .
- the spring 540 stores energy within itself when it is in tension.
- an energy storage device such as a reservoir or container of pressurized gas, a battery, or other energy storage device could be used in lieu of the spring 540 .
- valves, tubing and other structure may be used to route the pressurized gas to desired locations in the handle 302 such that the energy stored in the gas is used to bias the distal slider 534 proximally, and/or to perform other actuation functions within the handle 302 and/or the tool 300 .
- the trigger 308 may be configured differently, such that actuation of the anastomosis tool 300 may be performed simply by contacting the trigger 308 with a finger, or moving the trigger 308 through a more limited range of motion. Alternately, the trigger 308 may be omitted altogether, and the anastomosis tool 300 may be actuated remotely by a computer, dedicated control station, handheld computing device, or other device.
- the second cable 490 is connected to the distal slider 534 in any appropriate way.
- at least one aperture or port may be formed in the distal slider 534 , and at least one cable 480 is inserted into at least one aperture and secured thereto.
- an end of the cable or cables 480 may be wound around all of or a portion of, crimped to, welded to, or secured by adhesive to the distal slider 534 .
- the second cable 490 may have an amount of slack in it when the distal slider 534 is in the first, predeployment position shown in FIG. 70 .
- the amount of slack, if any, is related to the distance traveled by the distal slider 534 during actuation, as described in greater detail below.
- the distal slider 534 includes a verification stub 560 .
- the verification stub 560 extends substantially upward from the upper end of the distal slider 534 .
- the verification stub 560 extends from a different portion of the distal slider 534 , or in a different direction.
- the verification stub 560 may extend into or through a slot 562 through the handle 302 . Because it is connected to the distal slider 534 , the verification stub 560 moves along the slot 562 in the handle 302 when the distal slider 534 moves during operation, as described below. As a result, the position of the verification stub 560 may be used to confirm visually whether a particular anastomosis tool 300 has been actuated or not.
- the verification stub 560 may be located in a first position before the anastomosis tool 300 is actuated, and in a second position after the anastomosis tool 300 is actuated, such that the user can determine whether the anastomosis tool 300 has been actuated by viewing the position of the verification stub 560 .
- the rocker 508 includes a ratchet 564 extending substantially downward from a location distal to the rocker axle 510 .
- the ratchet 564 extends in a different direction.
- the ratchet 564 includes a member 566 at its lower end extending substantially transverse to the remainder of the ratchet 564 .
- the member 566 extends in a different direction.
- the member 566 is a notch or other element defined in the ratchet 564 .
- the ratchet 564 moves in conjunction with the rocker 508 .
- the ratchet 564 moves downward as well.
- a pawl feature 568 is configured to engage the member 566 of the ratchet 564 after the ratchet 564 has moved downward a particular distance, allowing the ratchet 564 to continue to move downward after engagement, but preventing the ratchet 564 from moving back upward past the pawl feature 568 after engagement.
- the rocker 508 , sliders 522 , 534 , and/or other mechanisms in the handle are not used, and a different mechanism or mechanisms are used to actuate the tissue effector 400 and complete the anastomosis.
- a fluid logic mechanism may be used, where a container of gas within the handle or a connection to a tank outside the handle provides gas under pressure to a switching assembly or other mechanism.
- the switching assembly utilizes and/or directs the pressure of the gas to successively actuate the components of the tissue effector 400 .
- Vacuum or liquid may be used instead of gas, if desired.
- the handle 302 may include an electromechanical assembly under analog or digital control, such that actuation of the trigger 308 or other component causes actuation of the tissue effector.
- an end of the graft vessel 404 is incised substantially in the longitudinal direction to form flaps 404 therein.
- At least one incision may be made in a different direction.
- two incisions are made to create two flaps 404 of substantially the same size.
- the flaps 404 may be of different sizes.
- more than two flaps 404 may be created with more than two incisions.
- a single flap 404 is made with a single incision.
- the graft vessel 404 is loaded onto the staple holder 38 as described above, such that each flap 408 is held between a graft clip 412 in the closed position and a flap receiving surface 406 , and the graft vessel 404 extends between the arms 402 of the staple holder 38 .
- the anastomosis tool 300 is initially in a pre-deployment configuration. In this configuration, the distal arm 518 of the rocker 508 is at an uppermost position, the trigger 308 correspondingly extends outward from the handle 302 to its greatest extent, and the proximal arm 514 of the rocker 508 is at a lowermost position.
- the distal end 520 of the distal arm 518 of the rocker 508 may engage the contact surface 548 of the distal slider 534 at or near the uppermost end of the contact surface 548 .
- This contact may be between the posts 544 of the distal arm 518 and the contact surface 548 , and/or between another portion of the distal arm 518 and the contact surface 548 .
- the stops 596 of the holder 594 hold the distal slider 534 substantially in place against the proximal bias exerted by the spring 540 .
- contact between the rigid distal arm 518 and the contact surface 548 holds the distal slider 534 substantially in place against the proximal bias exerted by the spring 540 .
- the proximal end 516 of the proximal arm 514 may be spaced apart from the lower portion 530 of the proximal slider 522 , or may be in contact with the lower portion 530 of the proximal slider 522 .
- the proximal slider 522 is biased distally to its most distal possible position.
- the proximal slider 522 is positioned differently in the pre-deployment configuration.
- the rocker 508 and/or the trigger 308 may be in a different position in the pre-deployment configuration, particularly where the rocker 508 and/or trigger 308 are shaped or configured differently than shown in FIG. 70 . If so, the rocker 508 may engage the proximal slider 522 and/or the distal slider 534 in a different manner than described above.
- the position 590 of the proximal slider 522 is at an initial position, and the position 592 of the distal slider 534 is also at an initial position.
- the positions 590 , 592 of the sliders 522 , 534 on the graph of FIG. 77 are qualitative, and are shown with respect to an arbitrary point selected between them. That is, the graph of FIG. 77 illustrates an exemplary set of motions of the sliders 522 , 534 over time.
- the first cable or cables 480 are connected to the proximal slider 522 and the second cable 490 is connected to the distal slider 534 , as described above.
- both cables 480 , 490 include some slack, such that a small initial motion of the trigger 308 takes up the slack and causes the cables 480 , 490 to become tensioned. In this way, small motions of the trigger 308 before deployment is intended do not begin the actuation of the anastomosis tool 300 .
- one or more of the cables 480 , 490 are tensioned in the pre-deployment configuration.
- the second cable 490 is also connected to the sled 482 in the tissue effector 400 , as described above.
- the sled 482 in the pre-deployment configuration the sled 482 is positioned such that each ramp element 446 is located within the corresponding passage 440 in the corresponding arm 402 , proximal to the connector bays 448 .
- the sled 482 in the pre-deployment configuration the sled 482 is positioned such that each vein knife 432 is located proximal to the vein flap 408 held between the graft clip 412 and the corresponding flap receiving surface 406 .
- the sled 482 is positioned differently in the pre-deployment configuration.
- each ramp element 446 may be positioned initially in a location distal to the connector bays 448 .
- each flap 408 is held between a graft clip 412 and a flap receiving surface 406 as described above, such that the graft vessel 404 extends between the arms 402 of the tissue effector 400 .
- the flaps 408 are held on the undersides of the arms 402 .
- Each flap 408 is held by the corresponding graft clip 412 such that a portion of the flap 408 at its root 405 , which is the portion of the flap 408 at or in proximity to its intersection with the tubular portion of the graft vessel 404 , is exposed.
- the root 405 of each flap 408 is configured to contact the outer surface of the target vessel, as described in greater detail below.
- the orientation of the tissue effector 400 may be changed relative to the handle 302 .
- the tissue effector 400 can be oriented relative to the target vessel such that the anvil arm 14 is aligned with it, and the handle 302 can be placed in a convenient position for the user.
- the user depresses the buttons 278 , disengaging the teeth 284 of the cog 282 from the detents 310 of the receiving opening 309 .
- the tissue effector 400 is then rotated to the desired orientation.
- the buttons 278 are then released, allowing the teeth 284 of the cog 282 to engage once again the detents 310 of the receiving opening 309 .
- the cog 282 is thus held securely in place in its new orientation.
- the distal end of the anvil arm 14 is spaced apart from the staple holder 38 .
- the anvil arm 14 is inserted through the wall of the target vessel 580 .
- the target vessel 580 may be a coronary artery, if the anastomosis tool 300 is used in the course of a CABG procedure, or any other appropriate bodily vessel or structure.
- the anvil arm 14 has a cross-section small enough to allow it to enter the target vessel 580 easily and to result in minimal or no leakage from the target vessel after the anvil arm 14 is removed.
- the distal tip of the anvil arm 14 may be sharp such that the anvil arm 14 itself penetrates the wall of the target vessel 580 , resulting in an opening in the wall of the target vessel 580 substantially the same size as the cross-section of the anvil arm 14 .
- a sharp retractable projection such as but not limited to the blade 78 of FIGS. 13-14 or the blade 84 of FIGS. 15-16 , is provided at the distal end of the anvil arm 14 . The retractable projection is extended to allow the distal end of the anvil arm 14 to penetrate the wall of the target vessel 580 , then retracted into the anvil arm 14 .
- the retractable projection may be a wire, a blade, a substantially conical member, a screw or a screw-tipped rod, or any other sharp structure or mechanism capable of penetrating the wall of the target vessel 580 .
- a retractable projection alternately may be as described in U.S. patent application Ser. No. 10/134,081, which is herein incorporated by reference in its entirety.
- a separate mechanism or structure is used to penetrate the wall of the target vessel 580 , and the anvil arm 14 is later inserted through that penetration.
- the cutter 200 includes a sharp point at its distal end, where that sharp point extends out of the distal end of the anvil arm 14 to puncture the wall of the target vessel 580 . If so, the cutter 200 may be actuated in a direction the reverse of that described below.
- the distal end of the anvil arm 14 enters the lumen of the target vessel 580 .
- the anvil arm 14 is advanced into the target vessel 580 until a tissue stop 220 on the anvil arm 14 encounters the edge of the penetration in the wall of the target vessel 580 .
- the tissue stop 220 is substantially flat and/or blunt, and extends upward or in another direction relative to the anvil arm 14 to increase the height and/or width of the anvil arm 14 .
- the tissue stop 220 increases the cross-section of the anvil arm 14 such that the anvil arm 14 cannot easily move further into the penetration in the wall of the target vessel 580 after the tissue stop 220 encounters the outer wall of the target vessel 580 .
- tissue stop 220 is blunt, it does not penetrate the wall of the target vessel 580 or act to expand the size of the existing penetration. Thus, the distance between the distal end of the anvil arm 14 and the tissue stop 220 substantially determines how much of the anvil arm 14 is allowed into the lumen of the target vessel 580 .
- the distal end of the anvil arm 14 is stabilized after insertion into the target vessel 580 .
- This stabilization may be performed by, for example, extending pins (not shown) from the staple holder 38 to the anvil arm 14 , where the pins act to hold the distal end of the anvil arm 14 substantially in place.
- the pins may be sized and shaped to fit into depressions, slots or other features on the anvil arm 14 . In this way, potential deflection of the distal end of the anvil arm 14 may be further reduced without the need for increasing the stiffness of the anvil arm 14 .
- the pins are retracted or otherwise moved away from the anvil arm 14 , freeing it.
- Different or additional mechanisms, structures or methods may be used to stabilize the anvil arm 14 .
- a different part of the anvil arm 14 is stabilized in addition to or instead of the distal end of the anvil arm 14 .
- an operator depresses the trigger 308 of the anastomosis tool 300 .
- the rocker 508 begins to rotate about the rocker axle 510 , such that the distal arm 518 moves downward and the proximal arm 514 of the rocker 508 moves upward.
- the distal end 520 of the distal arm 518 moves downward.
- the stops 596 of the holder 594 continue to hold the distal slider 534 substantially in place against the proximal bias exerted by the spring 540 .
- the distal slider 534 does not substantially move as the trigger 308 is initially depressed.
- the contact surface 548 of the distal slider 534 is curved to substantially match the travel of the distal end 520 of the distal arm 518 . That is, the radius of curvature of the contact surface 548 relative to the rocker axle 510 is substantially the same as the path of motion of the distal end 520 of the distal arm 518 as the rocker 508 rotates, and thus does not substantially interfere with the motion of the distal arm 518 .
- the distal end 520 of the distal arm 518 holds the distal slider 534 in substantially the same position as the distal arm 518 moves relative to the contact surface 548 , due to the match between the curvature of the contact surface 548 and the motion of the distal end 520 of the distal arm 518 .
- the contact surface 548 is configured differently.
- the distal slider 534 may be configured to move as the trigger 308 is initially depressed, if desired.
- the proximal end 516 of the proximal arm 514 moves upward as the trigger 308 is depressed, and contacts the lower portion 530 of the contact feature 528 of the proximal slider 522 if it is not initially in contact with the proximal slider 522 . As the proximal end 516 of the proximal arm 514 continues to move upward, it continues to engage the lower portion 530 of the contact feature 528 of the proximal slider 522 .
- the lower portion 530 of the contact feature 528 is shaped such that a component of force exerted by the proximal end 516 of the proximal arm 514 on that lower surface 530 is converted into a substantially translational force acting on the proximal slider 522 to urge it proximally.
- the lower portion 530 of the contact feature 528 is angled proximally and downward.
- the ribs 526 and corresponding flanges 524 of the proximal slider 522 substantially linearly constrain the motion of the proximal slider.
- the angle of the lower surface 530 relative to the arcuate motion of the proximal end 516 of the proximal arm 514 results in the conversion of the substantially arcuate motion of the proximal end 516 of the proximal arm 514 to substantially linear motion of the proximal slider 522 .
- the first cable or cables 480 are fixed to the anvil 10 . Because the anvil 10 is in turn fixed relative to the shaft 304 , the proximal motion of the first cable or cables 480 removes slack from, then tensions, the first cable or cables 480 .
- the first cable or cables 480 pass through at least a portion of the cable housing 306 . As described above, the cable housing 306 curves between the shaft 304 and the tissue effector 400 .
- the tension in the first cable or cables 480 causes the cable housing 306 to move. That is, the tension in the first cable or cables 480 acts upon the flexible cable housing 306 , causing its curvature to decrease.
- the cable housing 306 is at least partially flexible, the cable housing 306 possesses stiffness longitudinally.
- the staple holder 38 is biased away from the anvil 10 by a biasing element 475 , which tends to move the tissue effector 400 to an open position.
- the biasing element 475 may be a coil spring, leaf spring, or any other structure or mechanism capable of applying a biasing force.
- the distal end of the cable housing 306 exerts a force on the anvil 10 that overcomes the bias of the biasing element 475 , causing the anvil 10 to rotate about a pivot point such as the pin 226 to a standby position.
- the anvil arm 14 remains substantially stationary within the target vessel 580 , while the staple holder 38 rotates.
- the staple holder 38 and anvil 10 may be actuated to move between the position shown in FIG. 34 and the position shown in FIG. 44 by any structure, mechanism or method.
- a second cable housing (not shown) is provided. If so, the first cable or cables 480 may extend through the cable housing 306 as described above, and the second cable or cables 490 may extend through the second cable housing. In this way, the forces exerted along the first cable or cables 480 and cable housing 306 are substantially isolated from the forces acting along the second cable or cables 490 and the second cable housing.
- the staple holder 38 holds a root 405 of each flap 408 against or in proximity to the outer surface of the target vessel.
- the flaps and graft vessel are not shown in FIG. 44 . That is, the roots 405 of the flaps 408 are apposed to the outer wall of the target vessel 580 .
- a portion of the intimal layer of the graft vessel 404 at the root 405 of each flap 408 is placed against the outer wall of the target vessel 580 .
- the flaps 408 are held by the staple holder 38 in a substantially fixed position relative to the surface of the target vessel 580 , such that the end of the graft vessel 404 is substantially immobile relative to the wall of the target vessel 580 .
- the position of the end of the graft vessel 404 relative to the wall of the target vessel 580 remains substantially unchanged throughout the duration of the anastomosis procedure.
- the contact surface 206 of the anvil arm 14 is substantially in contact with the inner surface of the wall of the target vessel 580 .
- the perimeter of the end of the graft vessel 404 defines a closed area on the wall of the target vessel.
- connection made between the end of the graft vessel 404 and the wall of the target vessel is substantially registered with an opening made within the closed area in the wall of the target vessel, regardless of the order in which the connection and the opening are made. Further, the position of the end of the graft vessel 404 relative to the wall of the target vessel 580 substantially maintains position registration throughout the duration of the anastomosis procedure relative to the opening in the wall of the target vessel through which the anvil arm 14 is inserted.
- the engagement member 216 engages the receiver 218 .
- the receiver 218 is defined in the sled 482 .
- the receiver 218 may be a separate component from the sled 482 .
- the optional safety feature 210 is utilized, the relative motion of the staple holder 38 and the anvil 10 causes the staple holder 38 to contact the safety feature 210 and urge it downward against its upward bias. Consequently, the tip 212 of the safety feature 210 is moved downward out of engagement with the safety recess 214 of the cutter 200 .
- another structure or mechanism is configured to engage the safety feature 210 when the staple holder 38 and anvil 10 are moved together, so as to urge the tip 212 out of the safety recess 214 .
- the cutter 200 is freed for translation along the channel 246 .
- an interface structure 238 may be connected to or formed into the staple holder 38 .
- the interface structure 238 engages the anvil 10 or a component associated with the anvil 10 as the staple holder 38 and the anvil 10 move to the standby position, such as by snapping onto a corresponding feature (not shown) on the anvil 10 .
- the interface structure 238 holds the staple holder 38 substantially fixed relative to the anvil 10 , in order to maintain registration between the target vessel, the graft vessel, the anvil 10 and the staple holder 38 .
- the interface structure 238 may be a tab, rail, bump, or any other feature that is capable of engaging a corresponding feature and holding the staple holder 38 substantially fixed relative to the anvil 10 .
- the interface structure 238 is formed into or connected to the anvil 10 and engages a corresponding feature on the staple holder 38 .
- the user continues to depress the trigger 308 .
- the rocker 508 continues to rotate about the rocker axle 510 such that the distal end 520 of the distal arm 518 continues to move downward, and the proximal end 516 of the proximal arm 514 continues to move upward.
- the proximal end 516 of the proximal arm 514 continues to move upward, its contact with the lower portion 530 of the contact feature 528 of the proximal slider 522 continues to urge the proximal slider 522 proximally.
- the user continues to depress the trigger 308 .
- the proximal end 516 of the proximal arm 514 continues to move upward, it moves past the intersection between the two portions 530 , 532 of the contact feature 528 , thereby contacting the upper portion 532 of the contact feature 528 .
- the upper portion 532 of the contact feature 528 provides substantially no resistance to the continued rotation of the rocker 508 , because it is substantially vertical or angled in a proximal direction as it extends upward.
- the proximal end 516 of the proximal arm 514 thus moves upward rapidly.
- the speed of the motion of the proximal end 516 of the proximal arm 514 is controlled to be the same as or slower than its speed while it contacts the lower portion 530 of the contact feature 528 .
- the proximal slider 522 may move distally at least slightly due to the arcuate motion of the proximal end 516 of the proximal arm 514 relative to the non-arcuate upper portion 532 of the contact feature 528 .
- the distal end 520 of the distal arm 518 continues to move downward along the contact surface 548 of the distal slider 534 .
- the posts 544 at the distal end 520 of the distal arm 518 are spaced apart from one another, such that a gap is present between them.
- the distal arm 518 may contact the contact surface 548 via the posts 544 during at least a portion of its travel. As the distal end 520 of the distal arm 518 moves downward, the posts 544 reach the bottom edge 570 of the contact surface 548 .
- the rocker 508 , the proximal slider, and the distal slider 534 are positioned relative to one another and shaped such that the posts 544 reach the bottom edge 570 of the contact surface 548 at substantially the same time that the proximal end 516 of the proximal arm 514 reaches the intersection between the two portions 530 , 532 of the contact feature 528 of the proximal slider 522 .
- the posts 544 When the posts 544 reach the bottom edge 570 of the contact surface 548 , they contact the members 600 of the holder 594 . As the distal end 520 of the distal arm 518 continues to move downward, the posts 544 thereby press the members 600 downward. As a result, the stops 596 are moved out of engagement with the bottom edge 570 of the contact surface 548 , such that the stops 596 no longer contact the distal slider 534 . Consequently, the stops 596 no longer restrain the distal slider 534 against proximal motion under the influence of the spring 540 .
- the width of the lower guide 552 is less than the width of the gap between the posts 544 , and the lower guide 552 is substantially aligned with the gap between the posts 544 .
- the lower guide 552 is free to slide through the gap between the posts 544 and through the proximal end of the holder 594 .
- the proximal motion of the distal slider 534 thus takes up the slack (if any) in the second cable 490 connected to the distal slider 534 , then causes that second cable 490 to move proximally.
- this proximal motion of the second cable 490 urges the sled 482 , which also is connected to the second cable 490 , into motion.
- at least one channel 496 is defined in the staple holder 38 , and the second cable 490 is guided by a corresponding channel 496 .
- the staple holder 38 is shaped such that the channel 496 curves and causes the second cable 490 to curve back in a proximal direction.
- the second cable 490 is connected to the sled 482 .
- the curvature of the channel 496 causes the second cable 490 to curve, such that the proximal motion of the second cable 490 pulls the sled 482 distally. In this way, proximal motion of the distal slider 534 causes the sled 482 to move distally.
- the sled 482 includes one or more ramp elements 446 , each movable within a corresponding passage 440 in an arm 402 of the staple holder 38 , as described above. Initially, the sled 482 is positioned such that each ramp element 446 is proximal to the most proximal connector bay 448 connected to the corresponding passage 440 . Thus, as the second cable 490 is tensioned and moved proximally by the distal slider 534 , and the sled 482 moves distally as a result, each ramp element 446 moves distally in its corresponding passage 440 .
- each additional ramp element 446 through its corresponding passage 440 occurs in the same or a similar manner.
- the ramp element 446 moves distally from its initial position, its distal end 474 contacts the most proximal connector deployer 452 .
- each connector deployer 452 initially is in a first position in which its outer end 454 extends into the passage 440 .
- the distal end 474 of the ramp element 446 contacts the most proximal connector deployer 452 , it urges that connector deployer 452 into the corresponding connector bay 448 .
- the distal end 474 of the ramp element 446 may be shaped such that its inner surface 476 curves or angles relative to the direction of travel of the ramp element 446 .
- a component of the force it exerts on the connector deployer 452 is substantially parallel to the longitudinal centerline of the corresponding connector bay 448 . That centerline may be substantially perpendicular to the direction of travel of the ramp element 446 , or may be otherwise oriented relative to the direction of travel of the ramp element 446 .
- the connector deployer 452 begins to move through the corresponding connector bay 448 , away from the passage 440 .
- a connector 464 is located in the connector bay 448 , inward from the connector deployer 452 .
- the tines 466 of the connector 464 initially may be biased against at least part of the corresponding connector bay 448 as described above, or the connector 464 may otherwise be held within the connector bay 448 prior to motion of the connector deployer 452 .
- the connector deployer 452 moves, it exerts a force on the corresponding connector 464 , overcoming the force with which the connector 464 is initially held in place and pushing the connector 464 inward.
- the registration element 458 (if used) translates along the registration feature 462 of the connector bay 448 .
- the registration element 458 reduces or eliminates lateral cocking of the connector deployer 452 during its translation through the connector bay 448 , such that the connector deployer 452 is maintained in substantially the same orientation throughout its travel.
- the tines 466 of the connector 464 move out of the connector bay 448 , penetrate the root 405 of the flap 408 held against the inner surface 450 of the arm 402 , then penetrate the wall of the target vessel 580 .
- One or more of the arms 402 may be angled relative to a horizontal plane to facilitate connecting the flaps of the graft vessel 404 to the wall of the target vessel 580 , where that angle is chosen to place connectors in a desired orientation relative to the surface of the target vessel 580 .
- the staples 464 enter the target vessel substantially perpendicular to it. However, the staples 464 can enter the target vessel at a different angle, and/or at different angles relative to one another.
- the staple bending features 572 are depressions in the surface of the anvil arm 14 , aligned with the connector bays 448 such that at least one tine 466 of at least one connector 464 encounters a staple bending feature 572 upon being pushed out of its connector bay 448 .
- One or more of the staple bending features 572 may be configured differently, or may be omitted altogether.
- the force transmitted from the ramp element 446 to the connector deployer 452 presses the tines 464 into the staple bending features 572 , causing them to deflect.
- the tines 464 may be deflected in any direction suitable for holding the flap 408 to the graft vessel 404 .
- the connector deployer 452 When the widest portion of the distal end 474 of the ramp element 446 encounters the outer end 454 of the connector deployer 452 , the connector deployer 452 reaches the end of its stroke through the connector bay.
- the connector 464 and the corresponding staple bending feature or features 572 are configured such that the deflection of the tines 446 , and thus the deployment of the connector 464 , is substantially complete when the corresponding connector deployer 452 reaches the end of its stroke.
- the ramp element 446 then continues its motion through the passage 440 to encounter the next connector deployer 452 , such that the staples 464 in each arm 402 are deployed sequentially.
- the ramp element 446 and passage 440 are configured such that the ramp element 446 moves in substantially the same direction as the sliders 452 , or is otherwise connected to the sliders 452 , such that two or more of the sliders 452 are actuated substantially simultaneously. That is, the sliders 452 may be actuated in series, in parallel, or in a different way. For example, the sliders 452 may be selectively actuated, such that a selected number of staples 464 can be deployed. The user can deploy a selected number of staples 464 based on the size of the graft vessel 404 or other relevant factors. That is, the staple line (the length along the target vessel 580 along which staples 464 are deployed) is adjustable.
- Such adjustment may be performed in any appropriate manner, such as by adjusting the distance traveled by each ramp element 446 during deployment of the staples 464 .
- other mechanisms or structures may be used to deploy the staples 464 from the connector bays 448 in a desired sequence.
- the staple holder 38 includes two spaced-apart arms 402 .
- a ramp element 446 proceeds distally through a corresponding passage 440 in each arm 402 .
- the connector bays 448 in each arm 402 are aligned in a substantially bilaterally symmetric manner.
- the staple holder 38 sequentially deploys pairs of staples 446 into tissue as the ramp elements 446 move distally.
- the connector bays 448 are staggered, such that staples 464 from each arm 402 are deployed at different times than staples from the other arm 402 .
- the sled 482 also includes vein knives 432 .
- Each vein knife 432 translates through a corresponding vein knife passage 430 defined by a first channel 426 in the graft clip 412 and a second channel 428 in the flap receiving surface 406 , as described above.
- the distal end 474 of each vein knife 432 is sharp.
- the vein knives 432 are initially in a first position, where the distal end 474 of each vein knife 432 is located proximal to the root 405 of the corresponding flap 408 .
- the sled 482 moves distally.
- the vein knives 432 which are connected to the sled 482 move distally as well through the corresponding vein knife passages 430 .
- each vein knife 432 moves distally, its sharp distal end 474 engages the proximal edge of the root 405 of the corresponding flap 408 , entering the tissue of the flap 408 and beginning to make an incision therein.
- the serrations 438 on the graft clip blades 436 assist in holding the flap 408 as the corresponding vein knife 432 incises it. Alternately, those serrations 438 may assist in incising the flap 408 , depending on their configuration. In addition, the serrations 438 may assist in holding the excess tissue incised from each flap 408 , after the vein knife 432 has made an incision through the entire flap.
- the vein knives 432 do not extend as far in the distal direction as the ramp elements 446 .
- each ramp element 466 reaches any given longitudinal position before the blade 434 of the corresponding vein knife 432 . Consequently, the ramp element 466 causes a staple 446 to deploy at a particular longitudinal position before the corresponding vein knife 432 extends the incision in the flap 408 to that longitudinal position.
- each flap 408 is held securely as it is cut by the corresponding vein knife 432 .
- the flap 408 is incised during or before deployment of a staple 446 at that position.
- Each vein knife 432 is positioned to cut the flap 408 far enough from the deployed staples 446 to minimize or eliminate interference with these staples 446 , but close enough to the staples 446 to cut away excess tissue on the flap 408 that is not needed for the finished anastomosis.
- the cutter 200 has been freed for translation.
- the cutter 200 is urged distally by the receiver 218 , which engages the engagement feature 216 of the cutter 200 .
- the receiver 218 may be defined in the sled 482 , as described above. As the sled 482 is pulled distally by the second cable 490 , the receiver 218 moves distally, thereby urging the engagement feature 216 of the cutter 200 distally. Alternately, the receiver 218 is not defined in the sled 482 . Instead, the receiver 218 is a separate structure that may be connected to the sled 482 , and that is configured to travel along a guide structure 241 .
- the guide structure 241 is a rail or other structure along which the receiver 218 slide, and the receiver 218 interfaces with and translates along the rail. Thus, the guide structure 241 guides the translation of the receiver 218 .
- a cavity 240 is provided in the staple holder 38 adjacent to the guide structure 241 to allow for motion of the receiver 218 along the guide structure 241 .
- the cavity 240 is sized to allow the receiver 218 to translate freely.
- the guide structure 241 is a hollow channel defined within the staple holder 38 , such that the walls of the channel guide the translation of the receiver 218 .
- the guide structure 241 may be any other structure or mechanism capable of guiding the translation of the receiver 218 .
- the guide structure 241 is substantially aligned with the anvil arm 14 . That is, the longitudinal centerline of the guide structure 241 is substantially parallel to the longitudinal centerline of the anvil arm 14 .
- motion of the receiver 218 along the guide structure 241 causes translation of the engagement feature 216 and therefore translation of the cutter 200 substantially parallel to the centerline of the anvil arm 14 .
- the receiver 218 may be actuated to translate along the guide structure 241 by the second cable 490 , which transmits force from the handle 302 .
- the actuator may convert stored energy to force that is applied to the cutter. Such stored energy may be provided by a spring, battery, source of compressed gas, or other source.
- any mechanism, structure or method, using stored energy or not may be used to translate the receiver 218 along the guide structure 241 .
- the particular mechanism, structure or method used to cause translation of the cutter 200 is not critical to the invention.
- the upper surface 252 of the cutter 200 is substantially planar proximal to the projection 208 .
- the biasing element 260 contacts the upper surface 252 of the cutter 200 and biases the cutter 200 downward.
- the cutter 200 includes a keel 264 that extends downward.
- the keel 264 may be formed into the cutter 200 , or may be a separate component connected to the cutter 200 .
- the keel 264 is substantially as wide as the adjacent portion of the cutter 200 . However, the keel 264 may be wider or narrower than the adjacent portion of the cutter 200 .
- the keel 264 is positioned at or near the distal end of the cutter 200 . Alternately, the keel 264 may be positioned at a different location on the cutter 200 .
- the cutter 200 includes at least one projection 208 extending substantially upward from a position at or near its distal end, and an engagement feature 216 extending upward from the upper surface 252 of the cutter 200 .
- the keel 264 of the cutter 200 is spaced apart from the projection 208 , differing from the embodiment of FIG. 37-38 in which the keel 264 is adjacent to the projection 208 .
- the keel 264 can project a smaller distance downward while moving the projection 208 substantially the same amount upward and downward. Consequently, the keel 264 as a whole can be made smaller.
- the cutter 200 includes at least one projection 208 extending substantially upward from a position at or near its distal end, and an engagement feature 216 extending upward from the upper surface 252 of the cutter 200 .
- the cutter 200 includes a first keel 264 and a second keel 265 .
- the first keel 264 may be configured similarly to the keel 264 of FIG. 43
- the second keel 265 may be configured similarly to the keel 265 of FIG. 43A .
- the first keel 264 extends further below the body of the cutter 200 than the second keel 265 .
- a third lower opening (not shown) is defined through a lower surface 256 of the anvil 10 , in addition to the first lower opening 254 and the second lower opening 268 .
- the third lower opening is spaced apart from the second lower opening 268 , and is positioned distal to the second lower opening 268 .
- the first keel 264 initially extends into the second lower opening 268
- the second keel 265 initially extends into the first lower opening 254 .
- the keel 264 initially extends into the first lower opening 254 , which is defined through a lower surface 256 of the anvil 10 .
- the keel 264 may extend completely through the first lower opening 254 , such that its lowest point extends outside the anvil 10 .
- the keel 264 is biased downward into the first lower opening 254 as a result of the downward force exerted on the cutter 200 by the biasing element 260 .
- the projection 208 remains below the contact surface 206 of the anvil arm 14 . In this way, the projection 208 does not extend out of the anvil arm 14 while the anvil arm 14 is inserted into the wall of a target vessel.
- the keel 264 need not extend into or through the first lower opening 254 as far as the keel 264 of the cutter 200 of FIGS. 37-38 . As a result, less clearance for the motion of the keel 264 need be provided, and the tissue effector 400 may be made more compact.
- the first lower opening 254 extends along a fixed length of the lower surface 256 of the anvil 10 . As the cutter 200 translates distally, the keel 264 continues to remain at least partially within the first lower opening 254 , such that the projection 208 continues to remain below the contact surface 206 of the anvil arm 14 .
- the keel 264 may be positioned proximal to the distal end of the first lower opening 254 .
- the length of the first lower opening 254 is selected to cause the projection 208 to remain below the contact surface 206 of the anvil arm 14 across that distance. That is, this distance is selected such that the projection 208 on the cutter 200 does not engage the wall of the target vessel until the projection 208 is positioned within the circumference of the graft vessel. That is, the connection between the graft vessel and the target vessel substantially defines a closed area, and the projection 208 is configured to engage the wall of the target vessel within that closed area.
- the projection 208 makes an incision completely within the connection between the graft vessel and the target vessel, completing the anastomosis between the two vessels and minimizing or eliminating leakage at the anastomosis site. While the projection 208 on the cutter 200 remains below the upper surface of the anvil arm 14 , it neither engages nor cuts the wall of the target vessel.
- the cutter 200 continues to advance distally as the receiver 218 continues to urge the engagement feature 216 distally. As described above, at least the distal end of the cutter 200 is biased downward. As the cutter 200 advances distally, the keel 264 encounters the distal end of the first lower opening 254 . This encounter, and the continued proximal translation of the cutter 200 , causes the keel 264 to move upward relative to the anvil arm 14 .
- the keel 264 and/or the distal end of the first lower opening 254 may be constructed to provide a smooth, gradual upward motion of the keel 264 , such as by providing a gradual slope on the keel 264 and/or the distal end of the first lower opening 254 .
- the keel 264 and/or the distal end of the first lower opening 254 may be constructed to allow or cause the keel 264 to move upward abruptly upon encountering the distal end of the first lower opening 254 .
- the upward motion of the keel 264 causes the distal end of the cutter 200 and the projection 208 to move upward.
- the size and position of the first lower opening 254 including the position of the distal end of the first lower opening 254 , control the motion of the cutter 200 and the projection 208 in the vertical direction.
- the keel 264 contacts the distal end of the first lower opening 254 in the same manner as the cutter of FIGS. 37-38 .
- the projection 208 may be protected from inadvertent contact with the distal end of the first lower opening 254 .
- the initial position of the cutter 200 relative to the remainder of the tissue effector 400 may be different than that of the cutter 200 of FIGS. 37-38 , to ensure that the projection 208 enters the wall of the target vessel at a selected point relative to the tissue effector 400 .
- the second keel 265 and the first lower opening 254 are configured such that the second keel 265 contacts the distal end of the first lower opening 254 before the first keel 264 can contact the distal end of the second lower opening 268 . In this way, the distal end of the cutter 200 is prevented from contacting the distal end of the second lower opening 268 .
- the projection 208 moves upward through the upper opening 248 in the anvil arm 14 .
- the contact surface 206 of the anvil arm 14 is substantially adjacent to the inner surface of the wall of the target vessel.
- upward motion of the projection 208 through the upper opening 248 and above the contact surface 206 of the anvil arm 14 causes the projection 208 to enter the wall of the target vessel.
- the cutter 200 continues to move distally, such that the keel 264 moves out of the first lower opening 254 completely and contacts the bottom surface 266 of the channel 246 of the anvil arm 14 .
- the projection 208 is sized such that the projection 208 completely penetrates the wall of the target vessel when the keel 264 has moved proximally to the first lower opening 254 and is in contact with the bottom surface 266 of the channel 246 . That is, at least a portion of the projection 208 passes through the wall of the target vessel and enters the lumen of the target vessel. This initial penetration of the wall of the target vessel defines the starting point of an arteriotomy performed on the target vessel by the projection 208 . The starting point of the arteriotomy is spaced apart from the location on the target vessel at which the anvil arm 14 is inserted, because the cutter 200 and the projection 208 have moved proximally a selected distance before penetrating or incising the wall of the target vessel.
- tissue bridge The portion of the wall of the target vessel between the arteriotomy and the insertion point of the anvil arm 14 may be referred to as a tissue bridge.
- the incision is referred to as an arteriotomy for convenience, and this terminology does not limit the type of anastomosis that may be performed.
- anastomosis may be performed between two tissue structures that are not blood vessels, such as bile ducts.
- the projection 208 of the cutter 200 enters the wall of the target vessel at a location between the arms 402 of the staple holder 38 .
- Each arm 402 holds at least a portion of a flap 408 of the graft vessel 404 against the wall of the target vessel, such that the projection 208 enters the wall of the target vessel at a location between the flaps 408 .
- the length of the cutter 200 , the position of the projection 208 on the cutter 200 , and the placement of the first lower opening 254 may be selected such that the projection 208 enters the wall of the target vessel after at least one staple 446 is deployed into one of the flaps 408 and the wall of the target vessel.
- the projection 208 enters the wall of the target vessel before any of the staples 446 have been deployed, or after all of the staples 446 have been deployed.
- the length of the cutter 200 , the position of the projection 208 on the cutter 200 , and the placement of the first lower opening 254 may be selected such that the projection enters the wall of the target vessel at substantially the same time that one or more vein knives 432 begin to incise the corresponding flaps 408 .
- each connector deployer 452 actuates each connector deployer 452 in turn, causing the sliders 452 to sequentially deploy the corresponding staples 446 as described above.
- the vein knives 432 continue to move distally as the sled 482 advances distally, lengthening the incision in the root 405 of each flap 408 .
- the cutter 200 continues to advance distally as the receiver 218 continues to urge the engagement feature 216 distally. The cutter 200 incises the wall of the target vessel at a given longitudinal position at substantially the same time as each vein knife 432 incises the corresponding flap 408 at the that longitudinal position.
- the timing of the cutting action of the cutter 200 and the vein knives 432 is different, such that the cutter 200 incises the wall of the target vessel at a given longitudinal position either before or after each vein knife 432 incises the corresponding flap 408 at that longitudinal position.
- the lower surface of the keel 264 contacts the bottom surface 266 of the channel 246 during this translation.
- the contact between the keel 264 and the bottom surface 266 of the channel 246 counteracts the downward bias of the distal end of the cutter 200 .
- the projection 208 is maintained above the contact surface 206 of the anvil arm 14 .
- the projection 208 moves through the tissue of the wall of the target vessel in a direction substantially parallel to the longitudinal centerline of the anvil arm 14 , and incises the tissue of the wall of the target vessel to create an arteriotomy. Because the projection 208 is connected to and translated by the cutter 200 , which is within the target vessel, the arteriotomy is performed from within the target vessel.
- the tip of the projection 208 may maintain substantially the same height relative to the contact surface 206 of the anvil arm 14 during translation of the cutter 200 , or may change its height relative to the contact surface 206 of the anvil arm, as long as the projection 208 continues to incise completely through the wall of the target vessel.
- the lower surface of the second keel 265 and the lower surface of the first keel 264 both contact the bottom surface 266 of the channel 246 .
- the lower surface of the first keel 264 extends downward enough that the lower surface of the second keel 265 does not contact the bottom surface 266 of the channel 246 .
- a second lower opening 268 is defined through the lower surface 256 of the anvil arm 14 .
- the second lower opening 268 is distal to and substantially aligned with the first lower opening 254 .
- the cutter 200 continues to advance distally as the receiver 218 continues to impel the engagement feature 216 distally.
- the keel 264 encounters the proximal end of the second lower opening 268 . Because the distal end of the cutter 200 is biased downward, the keel 264 moves downward at least partially into the second lower opening 268 . The downward motion of the keel 264 causes the distal end of the cutter 200 and the projection 208 to move downward.
- the keel 264 and/or the proximal end of the second lower opening 268 may be constructed to provide a smooth, gradual downward motion of the keel 264 , such as by providing a gradual slope on the keel 264 and/or the proximal end of the second lower opening 268 .
- the keel 264 and/or the proximal end of the second lower opening 268 may be constructed to allow or cause the keel 264 to move downward abruptly upon encountering the proximal end of the second lower opening 268 .
- the first keel 264 moves as least partially into the third lower opening 269
- the second keel 264 moves at least partially into the second lower opening 268 .
- the downward motion of the distal end of the cutter 200 causes the projection 208 to retract into or completely through the upper opening 248 , such that the projection 208 no longer encounters the tissue of the wall of the target vessel.
- the projection 208 may be urged downward completely into the channel 246 , depending on the depth of the channel 246 and the height of the projection 208 .
- the upper tip of the projection 208 may remain within the upper opening 248 .
- the cutter 200 may stop its distal translation at substantially the same time that the projection 208 retracts completely into the upper opening 248 , or may continue to translate distally within the channel 246 before coming to a stop.
- the second lower opening 268 is not provided, and only the first lower opening 254 extends through the lower surface 156 of the anvil arm 14 into the channel 246 . In such a configuration, the cutter 200 is refracted in the proximal direction after the arteriotomy is formed, until the keel 264 moves downward into the first lower opening 254 and the projection 208 consequently retracts completely into the upper opening 248 .
- the sled 482 continues to move distally, such that the distal end 474 of the ramp element 446 actuates the most distal connector deployer 452 and deploys the corresponding staple 446 .
- the connection between the end of the graft vessel 404 and the target vessel 580 is then complete.
- the sled 482 continues to translate, such that each vein knife 432 then moves completely through the corresponding flap 408 .
- a portion of each flap 408 continues to be held between each graft clip 412 and corresponding flap receiving surface 406 .
- the rocker 508 completes its travel when the distal end 520 of the distal arm 516 contacts one or more of the ribs 556 in the handle 302 . This contact prevents further downward motion of the distal arm 518 , and thereby causes the rocker 508 to cease its motion. Alternately, at least a portion of the distal arm 516 and/or the proximal arm 514 contact a stop or other structure in the handle 302 which obstructs further motion of the rocker 508 . Alternately, the motion of the rocker 508 is stopped in a different way, such as by a braking or clutch mechanism. Thus, the corresponding travel of the second cable 490 and the connected sled 482 cease as well.
- the upper portion 532 of the contact feature 528 of the proximal slider 522 contacts the proximal end 516 of the proximal arm 514 .
- the spring 546 biases the proximal slider 522 distally.
- the upper portion 532 of the contact feature 528 is pressed against the proximal end 516 of the proximal arm 514 , holding the proximal arm 514 and the rocker 508 in place and substantially preventing rotation of the rocker 508 in a direction opposite to its previous motion.
- the proximal slider 522 does not contact the rocker 508 after the travel of the rocker 508 is complete.
- the lower guide 552 of the distal slider 534 contacts a stop 553 defined in or connected to the handle 302 .
- the stop 553 may be integrated with at least one of the ribs 556 .
- the stop 553 is positioned to interfere with further proximal motion of the distal slider 534 , such that contact between the lower guide 552 and the stop 553 causes the distal slider 534 to cease moving proximally.
- the distal slider 534 may include a verification stub 560 that extends substantially upward from the upper end of the distal slider 534 through a slot 562 in the handle 302 .
- the verification stub 560 is also in its most distal position.
- the verification stub 560 also translates proximally.
- the verification stub 560 has moved to its most proximal position as well.
- the user can confirm whether the anastomosis tool 300 has been completely actuated.
- the distal end 474 of at least one ramp element 446 may be visible after actuation of the anastomosis tool 300 if the distal end 442 of the passage 440 is open, providing another visual indication that the anastomosis tool 300 has been completely actuated.
- the distal end of the first lower opening 254 and the proximal end of the second lower opening 268 control the motion of the projection 208 and thereby control the penetration of the wall of the target vessel. That is, the distance between the distal end of the first lower opening 254 and the proximal end of the second lower opening 268 determines the length of the arteriotomy.
- the distal end 474 of the corresponding ramp element 446 extends out of the distal end 442 of the passage 440 to disengage the catch 608 of the snap arm 606 . That is, the lobe 610 of the snap arm 606 is positioned relative to the distal end 442 of the passage 440 such that the distal end 474 of the corresponding ramp element 446 encounters the lobe 610 near the end of the travel of the ramp element, pushing the lobe 610 out of engagement of the arm 402 and thus disengaging the catch 608 from the arm 402 .
- the corresponding graft clip 412 is thereby free to move out of the closed position, freeing the flap 408 held by that graft clip 412 .
- the vein knives 432 may be omitted, because the flaps 408 are freed in their entirety.
- the spikes 410 are omitted, such that the flaps 408 are not held in place on the flap receiving surface 406 after the snap arm 606 is disengaged from the arm 402 .
- the cutter 200 After performing the arteriotomy, the cutter 200 is in a distally-extended position. The cutter 200 remains in that position as the anvil arm 14 is removed from the target vessel 580 , where the tissue bridge 582 separates the anastomosis site from the hole 584 in the wall of the target vessel 580 through which the anvil arm 14 entered the target vessel 580 . Thus, the projection 208 does not extend out of the upper opening 248 during removal of the anvil arm 14 from the target vessel 580 . Alternately, after performing the arteriotomy, the cutter 200 may be moved proximally within the channel 246 in the anvil arm 14 before removing the anvil arm 14 from the target vessel 580 .
- the tissue effector 400 is then returned to the open position from the closed position, to allow the anvil arm 14 to be withdrawn from the target vessel 580 .
- the distal arm 518 of the rocker 508 has deflected at least a portion of the holder 594 .
- the deflected holder 594 exerts an opposing bias against the distal arm 518 of the rocker 508 .
- the biased holder 594 then acts against the distal arm 518 , pushing it upward and causing the rocker 508 to rotate about the rocker axle 510 .
- the proximal arm 514 of the rocker 508 moves downward toward its original position.
- the proximal end 516 of the proximal arm 514 moves downward against the upper portion 532 of the contact feature 528 of the proximal slider 522 , and continues to move downward past the intersection between the two portions 530 , 532 of the contact feature 528 .
- the proximal slider 522 is freed to move distally a small amount due to the bias of the spring 546 . This proximal motion relaxes the tension on the first cable 480 .
- the biasing element 475 pushes the staple holder 38 away from the anvil 10 , returning the tissue effector 400 to the open position.
- the tissue effector 400 thus no longer clamps the wall of the target vessel 580 , and the anvil arm 14 can be removed from the lumen of the target vessel 580 .
- the spacing between the staple holder 38 and the anvil 10 in the open position is selected to ensure adequate clearance for separation of the tissue effector 400 from the target vessel 580 .
- the staple holder 38 is moved far enough from the anvil 10 such that the spikes 410 are fully removed from the flaps 408 before the anvil arm 14 is removed from the target vessel 580 .
- the tissue effector 400 is returned to the open position in another manner.
- the completed anastomosis between the graft vessel 404 and the target vessel 580 remains.
- the hole 584 in the wall of the target vessel 580 through which the anvil arm 14 entered the target vessel 580 is small enough to prevent significant bleeding through the puncture site after the anvil arm 14 has been withdrawn.
- the hole 584 is closed by hand suturing.
- the hole 584 is closed with a biocompatible glue, adhesive or the like.
- the hole 584 is closed with a clip, clamp, or other implantable device that remains on the target vessel. Such a device may be positioned on the outer surface and/or inner surface of the target vessel, and may extend into the hole 584 .
- a device for closing the hole 584 may be constructed from nitinol or other superelastic or pseudoelastic material, or from stainless steel or other material, where that device moves between a first configuration and a second configuration during deployment, and where the second configuration holds the hole 584 closed.
- the hole 584 is less than substantially 2 mm wide, and advantageously less than 1 mm wide.
- the cutter 200 incises the wall of the target vessel while the staple holder 38 is stapling or otherwise connecting the graft vessel to the target vessel, as described in greater detail below.
- the staple holder 38 may completely staple or otherwise connect the graft vessel to the target vessel before the cutter 200 is urged forward, such that the two vessels are connected before the cutter 200 makes an incision between them.
- the cutter 200 incises the wall of the target vessel before the staple holder 38 has stapled or otherwise connected the graft vessel to the target vessel.
- a different embodiment of the anvil 10 also includes a cutter 200 moveable relative to the anvil 10 for making an incision in the wall of a target vessel.
- the anvil 10 , anvil arm 14 , staple holder 38 , and other components are substantially as described above with regard to FIGS. 34-38 and 44 - 49 .
- at least the distal end of the cutter 200 is biased upward.
- the actuation of the anastomosis tool 300 , the operation of the mechanisms within the handle 302 , and the operation of the tissue effector 400 are substantially as described above.
- the anvil insert 222 is connected to the anvil 10 .
- An aperture 230 is defined through the distal end of the anvil insert 222 into the cavity 228 defined within the anvil insert 222 , connecting the channel 246 to the cavity 228 .
- the cutter 200 extends through the aperture 230 in the anvil insert 222 , such that the distal end of the cutter 200 is positioned within the channel 246 and the proximal end of the cutter 200 is positioned within the cavity 228 .
- a cam 232 is positioned within the cavity 228 above the aperture 230 . Alternately, the cam 232 may be positioned differently relative to the aperture 230 .
- the cam 232 is a structure used in controlling the motion of the cutter 200 , as is described in greater detail below.
- At least the distal end of the cutter 200 may be biased upward. This biasing may be performed by any appropriate structure or mechanism, such as by one or more springs (not shown). Such a spring or springs may act in compression to push the distal end of the cutter 200 upward, or may act in tension to pull the distal end of the cutter upward.
- the cutter 200 may be constructed from an elastic or superelastic material that is formed in such a way as to produce an upward bias. The entire cutter 200 may be biased upward, if desired. At least the distal end of the cutter 200 is biased upward during the translation of the cutter 200 along the anvil arm 14 . Alternately, the cutter 200 is not biased, either upward or downward. Instead, the cutter 200 is urged upward and downward at different locations during its translation by the interaction between at least one cam follower on the cutter 200 and at least the cam 232 .
- the distal end of the anvil arm 14 is spaced apart from the staple holder 38 .
- the anvil arm 14 is inserted through the wall of the target vessel, as described above, such that the contact surface 206 of the anvil arm 14 is in substantial contact with the inner wall of the target vessel.
- the staple holder 38 and anvil 10 are moved relative to one another into the standby position, as described above. In the standby position, the cutter 200 is freed for translation along the channel 246 , because the tip 212 of the safety feature 210 no longer engages the safety recess 214 of the cutter 200 .
- At least the distal end of the cutter 200 is biased upward, and the cam 232 limits the upward motion of the cutter 200 by contacting at least a portion of the upper surface 252 of the cutter 200 .
- the cam 232 controls the motion of the distal end of the cutter 200 in the vertical direction as the cutter 200 translates within the channel 246 . Because the projection 208 is fixed to the cutter 200 , the cam 232 also controls the motion of the projection 208 in the vertical direction, and thus controls the location at which the projection 208 encounters the wall of the target vessel.
- a first cam follower 242 is defined on the upper surface 252 of the cutter 200 .
- the first cam follower 242 is a raised structure formed into the upper surface 252 of the cutter 200 .
- the first cam follower 242 is a separate structure or mechanism constructed separately from the cutter 200 and later connected to the cutter 200 .
- the first cam follower 242 may be located on a surface of the cutter 200 in addition to or instead of its upper surface 252 , depending on the position and configuration of the cam 232 .
- the first cam follower 242 may be shaped as a trapezoid or similar shape, or may be shaped differently.
- the cam 232 is fixed, and the first cam follower 242 is raised relative to the upper surface 252 of the cutter 200 . At least the distal end of the cutter 200 is biased upward. Thus, as the cutter 200 translates distally, the cam 232 engages the first cam follower 242 and causes the cutter 200 to move downward.
- the cam 232 and the first cam follower 242 are shaped to smoothly engage each other. Alternately, the first cam follower 242 is shaped to induce the cutter 200 to abruptly move downward when the first cam follower 242 initially encounters the cam 232 .
- the height of the first cam follower 242 relative to the contact surface 206 of the anvil arm 14 determines the distance that the distal end of the cutter 200 is moved downward.
- the cutter 200 may include a keel 264 or similar projection extending downward. As the distal end of the cutter 200 moves downward, the keel 264 or other projection moves into the first lower opening 254 .
- the first lower opening 254 does not control the motion of the cutter 200 ; instead, it provides a space for the keel 264 to move downward without interfering with the vertical motion of the distal end of the cutter 200 . If the keel 264 is omitted, the first lower opening 254 and the second lower opening 268 may be omitted as well.
- the connection between the graft vessel and the target vessel substantially defines a closed area
- the projection 208 is configured to engage the wall of the target vessel within that closed area. That is, the end of the graft vessel has a perimeter that contacts the side of the target vessel, such that the perimeter of the end of the graft vessel defines a closed area on the wall of the target vessel.
- the projection 208 makes an incision completely within the connection between the graft vessel and the target vessel, completing the anastomosis between the two vessels and minimizing or eliminating leakage at the anastomosis site. While the projection 208 on the cutter 200 remains below the contact surface 206 of the anvil arm 14 , it neither engages nor cuts the wall of the target vessel.
- the first cam follower 242 is sized to translate the tip of the projection 208 below the contact surface 206 of the anvil arm 14 for a selected distance such that the projection 208 does not engage the tissue of the target vessel until the projection 208 is positioned to enter the closed area on the wall of the target vessel defined by the perimeter of the end of the graft vessel.
- the cutter 200 continues to advance distally as the receiver 218 continues to impel the engagement feature 216 distally.
- the first cam follower 242 of the cutter 200 advances distally relative to the cam 232 .
- at least the distal end of the cutter 200 is biased upward.
- the first cam follower 242 decreases in height at its proximal end.
- the first cam follower 242 is constructed to provide a smooth, gradual upward motion of the distal end of the cutter 200 and the projection 208 , such as by providing a gradual slope between an upper surface 250 of the first cam follower 242 and an upper surface 252 of the cutter 200 .
- the first cam follower 242 may be constructed to allow the distal end of the cutter 200 and the projection 208 to abruptly snap upward as the first cam follower 242 moves distal to the cam 232 .
- the projection 208 moves upward through the upper opening 248 in the anvil arm 14 .
- the contact surface 206 of the anvil arm 14 is adjacent to the inner surface of the wall of the target vessel.
- upward motion of the projection 208 through the upper opening 248 causes the projection 208 to enter the wall of the target vessel.
- the projection 208 is sized, and the first cam follower 242 and cam 232 are shaped, such that the upward motion of the projection 208 after the first cam follower 242 has moved distal to the cam 232 causes the projection 208 to completely penetrate through the wall of the target vessel. That is, at least a portion of the projection 208 passes through the wall of the target vessel and enters the lumen.
- This initial penetration of the wall of the target vessel defines the starting point of an arteriotomy performed on the target vessel by the projection 208 .
- the starting point of the arteriotomy is spaced apart from the location on the target vessel at which the anvil arm 14 is inserted, resulting in a tissue bridge therebetween.
- the cutter 200 continues to advance distally as the receiver 218 continues to impel the engagement feature 216 distally.
- the upper surface 252 of the cutter 200 may contact the cam 232 during this motion, because the distal end of the cutter 200 continues to be biased upward.
- the projection 208 moves through the tissue of the wall of the target vessel in a direction substantially parallel to the longitudinal centerline of the anvil arm 14 . In this way, the projection 208 incises the tissue of the wall of the target vessel to create an arteriotomy.
- the tip of the projection 208 may maintain substantially the same height relative to the contact surface 206 of the anvil arm 14 during its distal translation, or may change its height relative to the contact surface 206 of the anvil arm 14 , as long as the tip of the projection 208 remains in the lumen of the target vessel during that translation.
- a second cam follower 244 is defined on the upper surface 252 of the cutter 200 , proximal to and spaced apart from the first cam follower 242 .
- a single cam follower is defined on the upper surface 252 of the cutter 200 , where that single cam follower includes a feature corresponding to the first cam follower 242 , a feature corresponding to the second cam follower 244 , and a section of reduced height between them corresponding to the upper surface 252 of the cutter 200 .
- the cutter 200 continues to advance distally as the receiver 218 continues to impel the engagement feature 216 distally. As a result of this motion, the second cam follower 244 contacts the cam 232 .
- the shape and size of the second cam follower 244 and cam 232 are selected such that the distal end of the cutter 200 is pushed downward far enough to cause the projection 208 to retract into the upper opening 248 .
- the projection 208 may be urged downward completely into the channel 246 , depending on the depth of the channel 246 and the height of the projection 208 . Alternately, the upper tip of the projection 208 may remain within the upper opening 248 .
- the cutter 200 may stop its distal translation at substantially the same time that the projection 208 retracts completely into the upper opening 248 , or may continue to translate distally within the channel 246 before coming to a stop.
- each cam follower 242 , 244 includes a location thereon having a height relative to the upper surface 252 of the cutter 200 sufficient to cause the projection 208 to be pushed out of contact with the wall of the target vessel. The distance between these locations defines the length of the arteriotomy.
- the cam followers 242 , 244 control the motion of the projection 208 and control the penetration of the wall of the target vessel.
- the cutter 200 After performing the arteriotomy, the cutter 200 is in a distally-extended position. The cutter 200 remains in that position as the anvil arm 14 is removed from the target vessel. Alternately, after performing the arteriotomy, the cutter 200 may be moved proximally within the channel 246 before removing the anvil arm 14 from the target vessel. The anvil arm 14 is removed from the target vessel after the anastomosis between the graft vessel and the target vessel has been completed. The hole at the puncture site and its closure are substantially as described above.
- the cutter 200 is initially in a distally-extended position, and retracted proximally in order to make an incision in the wall of the target vessel.
- the sled 482 is initially at its most distal location.
- the structures and mechanisms are substantially as described above, but operated in substantially the reverse order as described above.
- the channels 496 in the staple holder 38 are not needed, nor it is necessary to reverse the direction of motion of the second cable 490 as applied to the sled 482 ; rather, the sled 482 is deployed by pulling it proximally with the second cable 490 .
- the second cable 490 may be connected to the proximal end or other portion of the sled 482 .
- the cutter 200 and the projection 208 may be moved in a different way in order to incise the tissue of the wall of the target vessel.
- this embodiment is particularly suited for the use of a cutter 200 having a sharp distal end that initially extends out of the distal end of the anvil arm 14 in order to puncture the target vessel, after which the cutter 200 is retracted proximally to move its sharp distal end into the anvil arm 14 .
- each projection 208 is able to form a portion of the incision during translation of the cutter 200 .
- the distance that the cutter 200 is translated to form the incision is related to the distance between the projections 208 . That is, because each projection 208 forms a portion of the incision, no single projection 208 need be translated along the entire length of the incision.
- the projections 208 may be inserted into the wall of the target vessel, after which energy is applied to the projections 208 via the cutter 200 or directly in order to create an incision in the wall of the target vessel.
- an energy source (not shown) is connected to the cutter 200 .
- an ultrasound generator (not shown) may be connected to the cutter 200 and to the energy source.
- the ultrasound generator may be a piezoelectric crystal, as is standard, or a different structure or mechanism. Electrical energy may be applied to the ultrasound generator from the energy source, thereby causing the ultrasound generator to vibrate the projections 208 .
- energy may be applied from the energy source to the ultrasound generator after the projections 208 have been inserted into the wall of the target vessel, causing the projections 208 to move and thereby create an incision.
- a plurality of projections 208 spaced relatively close to one another are utilized.
- Other methods may be used to vibrate, move or oscillate the projections 208 .
- the length of the arteriotomy created by and the number of connectors 464 deployed by the tissue effector 400 are adjustable. By controlling these parameters, graft vessels of different diameters can be attached to a target vessel within a small range of angles relative to the graft vessel.
- the cross-sectional area of the connection between the graft vessel and the target vessel thus can be controlled across a range of two or more sizes while providing for a substantially fixed angle between the target vessel and the graft vessel.
- the number of connectors 464 deployed by the tissue effector 400 can be controlled in any appropriate manner. As one example, by varying the stroke of the sled 482 and therefore the length along each passage 440 that is traversed by the corresponding ramp element 446 of the sled 482 , the number of connectors 464 deployed as a result of motion of the sled 482 can be controlled. Control of the stroke of the sled 482 may be accomplished in any appropriate manner. For example, a control (not shown) connected to the handle 302 may allow the selection of a particular number of connectors 464 for deployment. Such a control may interact with the second cable 490 and/or other components of or connected to the handle 302 , in order to restrict the length that the second cable 490 moves upon actuation.
- a set of controllable stops may be provided within the tissue effector 400 .
- Each stop is positioned in proximity to a connector bay 448 , and is moveable between a first position that is out of the passage 440 adjacent to the connector bay 448 and a second position that is at least partially into the passage 440 . In the second position, the stop contacts and prevents further distal motion of the corresponding ramp element 446 of the sled 482 .
- the control interacts with the stops, such that when the control is used to select a particular number of connectors 464 for deployment, at least one stop is moved to its second position into a passage 440 of the tissue effector 400 . Each stop that is moved to its second position corresponds to the connector bay 448 from which the last of the selected number of connectors 464 is to be deployed. Other mechanisms, structures or methods may be used to control the number of connectors 464 that are deployed.
- the length of the arteriotomy is controlled to correspond to the length of tissue that is connected by the selected number of connectors 464 .
- the length of the arteriotomy can be controlled by controlling the motion of the cutter 200 .
- the motion of the cutter 200 can be controlled in several ways.
- the openings 254 , 268 in the anvil arm 14 can be changed both in length and position, to ensure that the arteriotomy is made to the correct length in the correct position.
- the openings 254 , 268 can be changed in length and position in any appropriate manner.
- one or more pins or other structures are extendable laterally across the openings 254 , 268 , such that the presence of those pins or other structures across the openings 254 , 268 effectively changes their length and position.
- Other mechanisms, structures or methods may be used to control the length and position of the openings 254 , 268 and/or the motion of the cutter 200 .
- FIGS. 17-23 illustrate an alternate anvil 100 that is used with a clamp 102 for controlling an incision site during an anastomosis procedure.
- the anvil 100 includes an anvil arm 104 and a handle 106 .
- the clamp 102 is slidable on the handle 106 to clamp the tissue of the target vessel 30 between the clamp 102 and the anvil arm 104 .
- the anvil arm 104 includes two rows of staple bending features 108 in the form of recesses positioned in two parallel rows along a top surface of the anvil arm 104 .
- the clamp 102 has a central opening 110 .
- a continuous anastomosis staple device 114 may be used to connect the graft vessel 32 to the target vessel 30 at the anastomosis site.
- the staple device 114 as shown in FIG. 19 includes a plurality of linkages forming a tubular configuration and a plurality of staple ends extending from the linkages.
- FIGS. 20-22 illustrate how the staple ends 116 of the staple device 114 are positioned in the end of the graft vessel 32 and are inserted through the incision 118 in the target vessel and bent over by contact with the staple bending features 108 of the anvil. As shown in FIG. 22 , the opposite ends 120 of the staple device 114 are folded over to complete the anastomosis.
- FIG. 23 illustrates a completed anastomosis performed according to the steps illustrated in FIGS. 19-22 .
- FIGS. 24-27 illustrate an alternate example of an anvil arm 14 d having a cutting wire 124 for forming the incision in the wall of the target vessel 30 .
- the cutting wire 124 may be used to form an incision before, during or after performing an end-to-side anastomosis procedure.
- a clamp 126 is used to trap the tissue at the anastomosis site between the clamp 126 and the anvil arm 14 d prior to performing the incision.
- the incision is spaced apart from the entry point of the anvil arm 14 d into the target vessel, creating a tissue bridge between the incision made in the wall of the target vessel and the entry point of the anvil arm 14 d into the target vessel.
- a portion of the contact between the anastomosed graft vessel and target vessel extends across the tissue bridge, such that the incision is located within the closed area defined by the contact between the perimeter of the end of the graft vessel and the wall of the target vessel.
- FIG. 28 shows a system 140 for controlling a tissue site and performing anastomosis.
- the system 140 includes an anvil arm 142 , a cutter 144 , and a graft vessel holder 146 all mounted on a handle 148 .
- the anvil arm 142 is mounted on the handle 148 and connected to a first actuator 150 that allows the anvil to be moved downward against the bias of a spring inside the handle.
- the cutter 144 may be spring biased or fixed and is positioned on the handle 148 directly above the anvil arm 142 .
- the graft vessel holder 146 includes two fixed arms 152 and two movable arms 154 .
- the two movable arms 154 are connected to a second actuator 156 on the handle 148 . Depression of the second actuator 156 against the bias of a spring within the handle causes the movable arms 154 to be moved downward away from the fixed arms to receive portions of a graft vessel between the movable and fixed arms.
- FIG. 29 The operation of the system 140 of FIG. 28 is shown in the cross sectional views of FIGS. 29-31 .
- an end of a graft vessel 32 is split so that each half of the graft vessel 32 can be held between a fixed arm 152 and a movable arm 154 .
- the first actuator 150 and the second actuator 156 are depressed to move the anvil arm 142 and the movable arms 154 downward.
- the split graft vessel 32 is then inserted between the fixed and movable arms 152 , 154 and the second actuator 156 is released to trap the ends of the graft vessel 32 , as shown in FIG. 30 .
- the anvil arm 142 is then inserted into the target vessel 30 in the same or similar manner as described above.
- FIG. 31 illustrates the tented target vessel 30 positioned adjacent the split and trapped graft vessel 32 in a position for performing anastomosis.
- the staple holders 38 are then advanced in the direction of the arrows D toward opposite sides of the anvil to staple the graft vessel and target vessel together.
- the staple holders 38 may hold a staple strip with an expandable backbone as shown in FIGS. 10A and 10B , or may instead or additionally hold different types of staples not connected to a backbone.
- the staple holders 38 may be provided with movable pins which allow the spacing between the staples to be adjusted depending on a size of the graft vessel used.
- staple bending features are provided on the anvil and staples are provided at an exterior of the tissue.
- the staples and/or staple holding strips may be positioned on the anvil and an exterior member with staple bending features may be moved toward the anvil to bend the ends of the staples and secure the graft and target vessels together.
- FIGS. 32-33 illustrate the use of an alternate anvil 130 for controlling the tissue at an anastomosis site.
- the anvil 130 includes a longitudinal opening 132 extending through the anvil 130 for application of a plurality of conventional sutures at the anastomosis site.
- the anvil 130 is inserted into the target vessel 30 and pulled against the interior wall of the target vessel 30 , tenting the target vessel as shown in FIG. 33 .
- Sutures 134 are then passed through the opening 132 in the anvil 130 and through the tissue of the target vessel wall on opposite sides of the anvil 130 . Once the sutures 134 are placed as shown in FIG. 33 , an incision is made in the target vessel along a center of the anvil 130 .
- each of the sutures 34 is then pulled out through the incision in the target vessel and cut so that an even row of sutures is provided along each of the sides of the incision.
- This system eliminates the tedious procedure of placing each individual suture very close to the edge of the incision in the very thin and flexible target vessel wall.
- Each of the sutures 134 is connected to a graft vessel in a conventional manner completing the anastomosis.
- the anvil as shown in FIGS. 32-33 allows quick and easy placement of a plurality of sutures in a very even manner close to the edge of the incision.
- the sutures of a conventional anastomosis are generally within about one millimeter of the edge of the incision and are advantageously within 0.5 millimeters of the edge of the incision.
- the cutter 200 does not include one or more projections 208 .
- the cutter 200 includes or is connected directly or indirectly to an energy source (not shown), which is used to create an opening in the wall of the target vessel.
- an energy source (not shown), which is used to create an opening in the wall of the target vessel.
- an emitter of laser or RF energy may be connected to the cutter 200 and to the energy source.
- the emitter of laser or RF energy is selectively actuated to transmit energy into the wall of the target vessel during translation of the cutter 200 , thereby creating an opening therein.
- the energy source may transmit a first type of energy to the emitter or other mechanism, which is converted by the emitter into a second type of energy delivered into the wall of the target vessel.
- the cutter 200 may include a projection 208 and additionally be connected to an energy source that is selectively actuated in order to assist in creating an opening in the wall of the target vessel.
- the cutter 200 does not translate through the anvil arm 14 . Instead, the cutter 200 is spatially removed from the anvil arm 14 , and creates an opening in the wall of the target vessel before or after the anvil arm 14 is inserted into the target vessel.
- the anvil arm 14 is inserted into a hole in the wall of the target vessel and the staple holder 38 deploys staples or other connectors to connect the graft vessel to the target vessel, as described above.
- the anvil arm 14 is removed, and an independent cutter 200 is then introduced through the hole in the wall of the target vessel.
- the cutter 200 may be configured as described above, including a projection 208 extending therefrom, or may be configured differently.
- the cutter 200 is manipulated relative to the connection between the target vessel and the graft vessel to create an opening at the junction therebetween. That is, registration is maintained between the cutter 200 and the junction between the end of the graft vessel and the wall of the target vessel.
- an imaging device (not shown) or other device may be connected to the cutter 200 or utilized in conjunction with the cutter 200 .
- a standard intravascular ultrasound unit may be connected to or used in conjunction with the cutter 200 .
- the intravascular ultrasound unit is connected to a display device (not shown) visible to the operator.
- the operator controls the intravascular ultrasound unit to visualize the interior of the target vessel and the surrounding area, thereby locating the junction between the target vessel and the graft vessel and allowing the cutter 200 to be controlled to incise an opening in the wall of the target vessel within the closed area on the wall of the target vessel defined by the perimeter of the end of the graft vessel, thereby allowing blood to flow through the opening into the target vessel.
- a different visualization device or devices may be inserted into or positioned outside of the target vessel to locate the junction with the graft vessel.
- the cutter 200 and any visualization device present in the lumen of the target vessel are then removed from the lumen of the target vessel, and the opening in the wall of the target vessel through which they were removed is sealed.
- the anvil arm 14 is inserted into a hole in the wall of the target vessel and the staple holder 38 deploys staples or other connectors to connect the graft vessel to the target vessel, as described above.
- the anvil arm 14 is removed, and the hole in the wall of the target vessel is removed.
- a cannula (not shown) is inserted into the lumen of the graft vessel through the free end of the graft vessel, and a stylet (not shown) is inserted through the lumen of the cannula.
- the cannula and the stylet are surgical instruments that are well known in the art.
- the stylet has a distal end configured to penetrate the wall of the target vessel.
- a sharp point, blade, or other penetrating member may be formed into or connected to the distal end of the stylet.
- the cannula may be inserted into the lumen of the graft vessel such that its distal end contacts the outer wall of the target vessel.
- a force is exerted on the stylet to cause its distal end to penetrate the wall of the target vessel. Consequently, an opening is created between the graft vessel and the target vessel within the circumference of the end of the graft vessel.
- the cannula and stylet are then removed from the lumen of the graft vessel through its free end.
- the anvil arm 14 is inserted into a hole in the wall of the target vessel and the staple holder 38 deploys staples or other connectors to connect the graft vessel to the target vessel, as described above.
- the anvil arm 14 is removed, and the hole in the wall of the target vessel is closed.
- An independent cutter 200 is then introduced through the wall of the graft vessel.
- the cutter 200 itself may create an opening in the wall of the graft vessel through which it can enter, or a separate implement may be used to create an opening in the wall of the graft vessel.
- the cutter 200 may be configured as described above, including a projection 208 extending therefrom, or may be configured differently.
- the cutter 200 may be J-shaped or L-shaped to facilitate creation of the opening between the graft vessel and the target vessel through the wall of the graft vessel.
- the cutter 200 is manipulated relative to the connection between the target vessel and the graft vessel to create an opening in the wall of the target vessel at the junction therebetween. That is, registration is maintained between the cutter 200 and the junction between the end of the graft vessel and the wall of the target vessel.
- the cutter 200 is then removed through the wall of the graft vessel, and the opening in the wall of the graft vessel is sealed.
- the tissue effector 400 may be connected directly to the handle 302 without an intervening shaft 304 , in a substantially rigid or substantially non-rigid manner.
- the mechanisms within the handle 302 may be reversed or otherwise rearranged, while maintaining their ability to actuate the tissue effector 400 . It is to be understood that the invention is not limited to the details of construction, the arrangements of components, and/or the process of performing anastomosis set forth in the above description or illustrated in the drawings.
- the invention is not limited to the performance of anastomosis in the context of a CABG procedure, nor it is limited to the anastomosis of two bodily vessels. Other tissue structures than vessels may be connected together within the body utilizing the present invention. Therefore, the invention is not to be restricted or limited except in accordance with the following claims and their legal equivalents.
Abstract
An exemplary surgical stapler may include a staple holder, staples positioned within the staple holder, and at least one structure slidable within the staple holder to contact directly at least one staple, where that direct contact deploys at least one staple from the staple holder. Another exemplary surgical stapler may include a staple holder, an anvil movably connected to the staple holder, staples positioned within the staple holder; and a sled slidable within the staple holder to contact directly at least one staple, where that direct contact urges at least one staple out of the staple holder and against the anvil.
Description
- This application is a continuation of U.S. patent application Ser. No. 11/378,127, which in turn is a continuation of U.S. Pat. No. 7,766,924, which in turn is a continuation-in-part of U.S. Pat. No. 7,285,131, which in turn is a continuation-in-part of U.S. Pat. No. 6,391,038, all of which are hereby incorporated by reference in their entirety.
- The invention relates to an apparatus and method for performing anastomosis.
- Anastomosis is a procedure by which two hollow tissue structures are joined together. More particularly, vascular anastomosis is a procedure by which two blood vessels within a patient are surgically joined together. Vascular anastomosis is performed during treatment of a variety of conditions including coronary artery disease, diseases of the great and peripheral vessels, organ transplantation, and trauma. In coronary artery disease (CAD) an occlusion or stenosis in a coronary artery interferes with blood flow to the heart muscle. Treatment of CAD involves the grafting of a vessel in the form of a prosthesis or harvested artery or vein to reroute blood flow around the occlusion and restore adequate blood flow to the heart muscle. This treatment is known as coronary artery bypass grafting (CABG).
- In the conventional CABG, a large incision is made in the chest and the sternum is sawed in half to allow access to the heart. In addition, a heart-lung machine is used to circulate the patient's blood so that the heart can be stopped and the anastomosis can be performed. In order to minimize the trauma to the patient induced by conventional CABG, less invasive techniques have been developed in which the surgery is performed through small incisions in the patient's chest with the aid of visualizing scopes. In both conventional and less invasive CABG procedures, the surgeon has to suture one end of the graft vessel to the coronary artery and the other end of the graft vessel to a blood-supplying artery, such as the aorta. The suturing process is a time consuming and difficult procedure requiring a high level of surgical skill. In order to perform the suturing of the graft to a target vessel such as the coronary artery or the blood supplying artery, a surgeon holds the edges of the incision in the target vessel with one handle and holds a needle in the other hand for suturing, or an assistant may hold the edges of the incision in the target vessel while a surgeon makes small stitches as close as possible to the edges of the incision. This suturing requires a high degree of precision and is quite time consuming. In addition, during conventional CABG procedures blood flow at the anastomosis site is stopped during suturing. This prevents bleeding from the incision site but also prevents blood from reaching a portion of the heart muscle served by the vessel. Further, during off-pump CABG procedures a side clamp or other device may be used to isolate a portion of the wall of the aorta to which a graft vessel is sutured. The use of a side clamp or similar device can cause emboli to detach from the wall of the aorta and enter the bloodstream, which is undesirable.
- Accordingly, it would be desirable to provide a vascular anastomosis system that allows the tissue at the anastomosis site to be controlled during suturing or other connection of the graft and target vessels. It would also be desirable to provide a vascular anastomosis system that allows the connection of a graft vessel to a target vessel prior to making an incision in the target vessel which allows blood flow between the target vessel and the graft vessel.
- In one aspect of the invention, an anastomosis tool includes a tissue effector connected to a handle by a shaft or other structure. The tissue effector may be orientable relative to the handle and/or shaft. For example, the tissue effector may be configured to roll, pitch and/or yaw relative to the shaft. In this way, the tissue effector can be placed in a desired orientation at an anastomosis site, and the handle can be held in a convenient position by the user.
- In another aspect of the invention, the tissue effector includes a staple holder moveable relative to an anvil. The staple holder holds at least one staple. The staple holder and the anvil are movable relative to one another, and move between an open position and a closed position. In the open position, the anvil is configured for insertion into a target vessel. The tissue effector may be biased to the open position with a spring or other mechanism or structure. In the closed position, the tissue effector holds the graft vessel against the wall of the target vessel.
- In another aspect of the invention, the staple holder includes two or more spaced-apart arms. An end of the graft vessel is cut to form at least one flap therein, and each flap is folded onto an arm of the staple holder. One or more graft clips are provided on each arm, where each graft clip secures a corresponding flap to the surface of the arm. Each clip is configured to move between an open position for receiving a flap and a closed position for securing the flap to the corresponding arm of the staple holder. Each graft clip may utilize a cam-lock feature or other structure or mechanism to hold itself in the closed position. One or more spikes may be provided on each arm, such that the spike or spikes penetrate and hold the corresponding flap to secure it more thoroughly to the staple holder.
- In another aspect of the invention, at least one of the arms of the staple holder includes at least one connector bay. A staple is held within each connector bay, such as by friction against its walls. One or more of the staples may be coated with sodium stearate or other biocompatible lubricant. A passage extends though each arm of the staple holder, where one end of each connector bay opens to that passage.
- In another aspect of the invention, a connector deployer extends into each connector bay, such that one end of the connector deployer contacts or is in proximity to the corresponding staple. One end of each connector bay faces the anvil when the tissue effector is in the closed position, and the other end of each connector bay opens to a channel or other structure. The ends of the connector bays facing the anvil are against or in proximity to the flaps of the graft vessel held against the arms of the staple holder, such that deployment of the staples from the connector bays causes those staples to penetrate the flaps.
- In another aspect of the invention, a ramp element is movable within each passage. The ramp element may be a component of a sled that is movable relative to the staple holder. Upon contacting a connector deployer, the ramp element urges it into the connector bay. In turn, that connector deployer urges the corresponding staple along the connector bay and out of the open end of the connector bay. As the ramp element translates along the channel, it sequentially encounters the connector deployers, thereby sequentially deploying the staples into the corresponding flap and into the wall of the target vessel. Alternately, at least one ramp element may be configured to deploy the staples in another manner, such as substantially simultaneously.
- In another aspect of the invention, excess tissue may be incised from the flaps of the graft vessel. Such incising may be performed before, during or after the connection of the graft vessel to the target vessel. For example, a vein knife is configured to move relative to a second channel defined in an arm of the staple holder, where the second channel is positioned relative to the flap such that the flap can be to a desired size. Each flap may be incised during or after the anastomosis, freeing the graft vessel from the staple holder. The vein knife may be connected to the sled directly or indirectly. Thus, as the sled translates along the first channel, the vein knife translates along the second channel and incises the corresponding flap.
- In another aspect of the invention, at least one graft clip blade optionally is attached to at least one of the arms of the staple holder. The graft clip blade has a serrated edge oriented to engage the corresponding flap of the graft vessel. The serrations on the edge of the graft clip blade assist in holding the corresponding flap securely, particularly as the vein knife incises excess tissue from the flap. Additionally, the graft clip blade may participate in incising excess tissue from the corresponding flap. Further, the serrations on the edge of the graft clip blade, in conjunction with the spikes, may assist in holding the excess tissue incised from each flap.
- In another aspect of the invention, a cutter translates along a slot in the anvil to create an opening in the wall of the target vessel. The timing of the staple deployments are coordinated with the motion of the cutter. As one example, the sled and the cutter move simultaneously. The sled and the cutter are shaped, positioned and/or otherwise configured to connect the graft vessel to the target vessel and to incise an opening in the wall of the target vessel in a coordinated manner.
- In another aspect of the invention, the distal end of one or more of the arms of the staple holder may be notched. After the staples have been deployed, the sled may be positioned such that its distal ends are located at the distal ends of the channels, such that the sled is visible via the notches. In this way, actuation of the sled and thus deployment of the staples can be visually confirmed.
- In another aspect of the invention, the handle includes a trigger operationally connected to the tissue effector, providing for actuation of the tissue effector with a single motion of the trigger. That is, a single input to the anastomosis tool both deploys staples and incises the target vessel at the anastomosis site, such that a single input to the tool creates a complete anastomosis between the graft vessel and the target vessel.
- In another aspect of the invention, the trigger is connected to a rocker that is configured to engage a proximal slider during actuation of the trigger. A first cable or other force transmission structure or mechanism is connected to the proximal slider, as well as to the anvil. The first cable is movable relative to a cable housing, which is fixed at one end to the staple holder and at the other end to the shaft. The anvil is fixed relative to the shaft as well. As the trigger is actuated, the rocker urges the proximal slider proximally, causing the proximal slider to pull the first cable proximally. Because the anvil is fixed relative to the shaft, the proximal motion of the first cable tensions the first cable. Because the cable housing is fixed to the staple holder, the tensioning of the first cable causes the staple holder to move closer to the anvil, thereby moving the tissue effector from the open position to the closed position. By moving the staple holder and keeping the anvil substantially stationary, the tissue effector closes without damaging the target vessel within which the anvil is positioned.
- In another aspect of the invention, the rocker is configured to engage a distal slider during actuation of the trigger. A second cable or other force transmission structure or mechanism is connected to the distal slider, as well as to the sled. As the trigger is actuated, the rocker releases the distal slider to move proximally, causing the distal slider to pull the second cable proximally. The second cable is routed over a bend on the staple holder such that the motion of the second cable pulls the sled in the distal direction.
- In another aspect of the invention, the flaps are decoupled from the tissue effector after the anastomosis is complete. Advantageously, this decoupling occurs as a result of the depression of the trigger, such that a single control is used to perform the entire anastomosis procedure. Decoupling may be performed by incising the flaps, by releasing the graft clips, or in any other appropriate manner.
-
FIG. 1 is a perspective view of an anvil and a plurality of staples according to a first aspect of the present invention. -
FIG. 2 is a perspective view of the anvil ofFIG. 1 being inserted into a target vessel. -
FIG. 3 is a perspective view of the anvil tenting a wall of a target vessel for an anastomosis procedure. -
FIG. 4 is a perspective view of a graft vessel placed adjacent an exterior of the tented target vessel for the anastomosis procedure. -
FIG. 5 is a perspective view of the staples being applied to the graft vessel and the target vessel during an anastomosis procedure. -
FIG. 6 is a perspective view of the completed anastomosis according to the first aspect of the present invention. -
FIG. 7 is a perspective view of a staple supported on a staple holding strip. -
FIG. 8 is a side view of the staple and staple holding strip ofFIG. 7 when the ends of the staple have been bent by contact with an anvil. -
FIG. 9 is a perspective view of an anvil and staple according to another aspect of the present invention. -
FIGS. 10A and 10B are is a side views of a plurality of staples supported on two examples of expandable staple holding strips. -
FIG. 11 is a perspective view of a portion of an anvil having a movable cutting device. -
FIG. 12 is a side view of an anvil having an external cutting device. -
FIGS. 12A and 12B are side views of a portion of an anvil and two cutting devices that snap onto the anvil. -
FIG. 13 is a side view of a portion of an anvil with an extendable cutting device. -
FIG. 14 is a side view of the anvil ofFIG. 13 with the cutting device extended. -
FIG. 15 is a side view of a portion of an anvil with an alternate extendable cutting device. -
FIG. 16 is a side view of the anvil ofFIG. 15 with the cutting device extended. -
FIG. 17 is a perspective view of an anvil according to a second aspect of the invention being inserted into a target vessel. -
FIG. 18 is a perspective view of the anvil ofFIG. 17 positioning inside a target vessel and a clamp being advanced to clamp the wall of the target vessel between the anvil and the clamp. -
FIG. 19 is a perspective view of a graft vessel being advanced to the target vessel with a continuous anastomosis staple while the anastomosis site on the target vessel is controlled by the anvil and clamp. -
FIGS. 20-22 are side cross sectional views of the steps of performing the anastomosis with the continuous anastomosis staple shown inFIG. 19 . -
FIG. 23 is a perspective view of the completed anastomosis performed as shown inFIGS. 19-22 . -
FIGS. 24-27 are perspective views of the steps of an alternative anvil and clamp system for controlling an anastomosis site and forming an incision through the clamped tissue of the target vessel. -
FIG. 28 is a perspective view of a system for controlling a tissue site and performing anastomosis according to the present invention. -
FIG. 29 is a cross sectional view taken along line C-C ofFIG. 28 , showing a first step of the anastomosis procedure. -
FIG. 30 is a cross sectional view taken along line C-C ofFIG. 28 , showing a second step of the anastomosis procedure. -
FIG. 31 is a cross sectional view taken along line C-C ofFIG. 28 , showing a third step of the anastomosis procedure. -
FIG. 32 is a perspective view of an anvil according to another aspect of the present invention for use with sutures. -
FIG. 33 is a perspective view of the anvil ofFIG. 32 positioned within a target vessel and used to locate a plurality of suture at an anastomosis site. -
FIG. 34 is a side cutaway view of a first embodiment of an anvil, a cutter and a staple holder, where the anvil and staple holder are spaced apart from each other. -
FIG. 35 is an end cross-section view of the anvil ofFIG. 34 . -
FIG. 36 is a side cutaway view of a portion of the anvil inserted into the lumen of a target vessel. -
FIG. 37 is a side view of the cutter. -
FIG. 38 is a perspective view of the cutter ofFIG. 37 . -
FIG. 39 is a side view of the distal end of a second embodiment of a cutter. -
FIG. 40 is a side view of the distal end of a third embodiment of a cutter. -
FIG. 41 is a side view of the distal end of a fourth embodiment of a cutter. -
FIG. 42 is a side view of a portion of a fifth embodiment of a cutter. -
FIG. 43 is a side view of the distal end of a sixth embodiment of a cutter. -
FIG. 43A is a side view of another embodiment of a cutter. -
FIG. 43B is a side view of another embodiment of a cutter. -
FIG. 44 is a side cutaway view of the anvil and staple holder ofFIG. 34 , where the cutter is in a first position. -
FIG. 45 is a side cutaway view of the anvil and staple holder ofFIG. 34 , where the cutter is in a second position. -
FIG. 46 is a side cutaway view of the anvil and staple holder ofFIG. 34 , where the cutter is in a third position. -
FIG. 47 is a side cutaway view of the anvil and staple holder ofFIG. 34 , where the cutter is in a fourth position. -
FIG. 48 is a side cutaway view of the anvil and staple holder ofFIG. 34 , where the cutter is in a fifth position. -
FIG. 49 is a side cutaway view of a second embodiment of an anvil and a staple holder, where the anvil and staple holder are spaced apart from each other. -
FIG. 50 is a side cutaway view of the anvil and staple holder ofFIG. 40 , where the cutter is in a first position. -
FIG. 51 is a side cutaway view of the anvil and staple holder ofFIG. 40 , where the cutter is in a second position. -
FIG. 52 is a side cutaway view of the anvil and staple holder ofFIG. 40 , where the cutter is in a third position. -
FIG. 53 is a side cutaway view of the anvil and staple holder ofFIG. 40 , where the cutter is in a fourth position. -
FIG. 54 is a side cutaway view of the anvil and staple holder ofFIG. 40 , where the cutter is in a fifth position. -
FIG. 55 is a side view of an anastomosis tool having a tissue effector and a handle. -
FIG. 56 is a perspective view of the tissue effector ofFIG. 55 in first position. -
FIG. 57 is a perspective view of the tissue effector ofFIG. 55 in a second position. -
FIG. 58 is another perspective view of the tissue effector ofFIG. 55 in the first position. -
FIG. 59 is a perspective view of the tissue effector ofFIG. 55 in the first position, with a graft vessel being connected to it. -
FIG. 59A is a detail cross-section view of a cam lock used in the tissue effector ofFIG. 55 , where the cam lock is in an open position. -
FIG. 59B is a detail cross-section view of the cam lock ofFIG. 59A in a closed position. -
FIG. 59C is an end view of the left half of the tissue effector ofFIG. 55 , in the closed position. -
FIG. 59D is an end view of the right half of another embodiment of the tissue effector ofFIG. 55 , in the closed position. -
FIG. 60 is a detail side view of a portion of the tissue effector ofFIG. 55 , showing an embodiment of a graft clip. -
FIG. 61 is a detail end view of a portion of the tissue effector ofFIG. 55 . -
FIG. 62 is a side view of a vein knife used in the tissue effector ofFIG. 55 . -
FIG. 63 is a side view of a graft clip blade used in the tissue effector ofFIG. 55 . -
FIG. 64 is a cross-section view of section A-A ofFIG. 57 . -
FIG. 65 is a perspective view of a connector deployer used in the arm ofFIG. 64 . -
FIG. 66 is a side view of a portion of the arm ofFIG. 64 as defined by the line B-B ofFIG. 64 . -
FIG. 67 is a perspective view of a staple configured to be deployed from the tissue effector ofFIG. 55 . -
FIG. 68 is a perspective view of a sled used in the tissue effector ofFIG. 55 . -
FIG. 69 is a bottom view of the sled ofFIG. 68 . -
FIG. 69A is a side view of the sled ofFIG. 68 . -
FIG. 70 is a side cross-section view of the handle ofFIG. 55 in a first position. -
FIG. 71 is a top view of a portion of a rocker utilized in the handle ofFIG. 55 . -
FIG. 72 is a side cross-section view of the handle ofFIG. 55 in a second position. -
FIG. 73 is a perspective view of a completed anastomosis. -
FIG. 74 is a perspective view of the tissue effector ofFIG. 55 with a graft vessel loaded onto it. -
FIG. 75 is a perspective view of the tissue effector ofFIG. 74 , where the anvil of the tissue effector has been inserted into the lumen of a target vessel. -
FIG. 76 is a perspective view of the tissue effector ofFIG. 74 , after the graft vessel has been connected to the target vessel and before the anvil of the tissue effector has been removed from the lumen of the target vessel. -
FIG. 77 is a graph qualitatively illustrating the positions of the distal slider and the proximal slider of the handle over time, with regard to an arbitrary point between them. - The use of the same reference symbols in different figures indicates similar or identical items.
- As shown in
FIG. 1 , one embodiment of ananvil 10 includes ahandle 12 and ananvil arm 14 extending from thehandle 12. Theanvil arm 14 may be oriented substantially perpendicular to thehandle 12, or oriented at a different angle. Theanvil arm 14 may be provided with one or more staple bending features 16 on opposite sides of theanvil arm 14. In theanvil 10 shown inFIG. 1 , the staple bending features 16 each include a plurality ofrecesses 20 which receive the ends ofstaples 22 and cause the staple ends to bend over. At least one of the staple bending features 16 may be configured differently or omitted, if desired. Thestaples 22 may be connected to astaple holding strip 24. Thestaples 22 are U-shaped and are arranged in a spaced apart parallel configuration such that thestaples 22 all lie in a single plane. Alternately, thestaples 22 may be shaped differently, and/or lie in one or more different planes. Anexemplary anvil arm 14 has a height and a width of about 2 mm or less, advantageously about 1 mm or less, and a length of about 2 to 15 mm, advantageously 5 to 12 mm. The length of the anvil will vary depending on the diameter of the graft vessel selected. The length to width ratio of theanvil arm 14 is substantially between 2:1 and 15:1. A different length to width ratio may be used, if desired. As one example, thestaples 22 have widths of about 0.2-3 mm. Advantageously, thestaples 22 have widths of substantially 2 mm or less. The leg lengths of thestaples 22 are substantially 0.2-3 mm. Alternately, other staple widths and/or leg lengths may be used. - The
anvil arm 14 has a sharpdistal end 28 for puncturing the tissue of a target vessel to insert theanvil arm 14 into the target vessel. As illustrated inFIG. 2 , theanvil arm 14 is inserted into a pressurized orunpressurized target vessel 30 by puncturing the target vessel with thedistal end 28 of theanvil arm 14. The hole that is formed in the wall of thetarget vessel 30 by theanvil arm 14 is small enough to prevent significant bleeding through the puncture site. Alternately, the hole is closed by hand suturing. Alternately, the hole is closed with a biocompatible glue, adhesive or the like. Alternately, the hole is closed with a clip, clamp, or other implantable device that remains on the target vessel. Such a device may be positioned on the outer surface and/or inner surface of the target vessel, and may extend into the hole. A device for closing the hole may be constructed from nitinol or other superelastic or pseudoelastic material, or from stainless steel or other material, where that device moves between a first configuration and a second configuration during deployment, and where the second configuration holds the hole closed. The hole is less than substantially 2 mm wide, and advantageously less than 1 mm wide. Alternately, theanvil arm 14 has a bluntdistal end 28 that is inserted through a hole created with a separate instrument, by a different instrument connected to theanvil arm 14, or by a sharp member connected to theanvil arm 14 that can be refracted into theanvil arm 14 or otherwise blunted or concealed after puncturing or creating an incision in the wall of the target vessel. - Once the
anvil arm 14 has been inserted into thetarget vessel 30, theanvil arm 14 may be pulled against an inner wall of thetarget vessel 30, causing tenting of the thin tissue of the vessel wall as illustrated inFIG. 3 . This tenting of the vessel wall provides control over the anastomosis site during an anastomosis procedure that is described with respect toFIGS. 4-6 . However, tenting of the target vessel wall need not be tented in order to control the anastomosis site during the anastomosis procedure. - As shown in
FIG. 4 , agraft vessel 32 is advanced to the anastomosis site and anend 34 of thegraft vessel 32 is positioned adjacent an exterior surface of thetarget vessel 30 at the anastomosis site. The tented portion of thetarget vessel 30 is positioned within the perimeter of theend 34 of thegraft vessel 32. As shown inFIG. 5 , astaple holder 38 is provided having twoarms 40 which are pivotally connected to thehandle 12 of theanvil 10. Alternatively, the pivotingarms 40 of thestaple holder 38 may be connected to thehandle 12 in a different way, or may be connected to a separate or additional device. Thearms 40 are spaced apart from one another across at least a part of their length. Thus, the graft vessel can be positioned between thearms 40. That is, thearms 40 are positioned on substantially opposite sides of the graft vessel. In this way, eacharm 40 may be positioned against a flap at an end of the graft vessel, as illustrated inFIGS. 29-31 . Thearms 40 may be configured differently, if desired. - Referring also to
FIG. 1 , thestaple holder 38 may be used to holdindividual staples 22 and/or staple holding strips 24. In one embodiment, eacharm 40 of thestaple holder 38 carries one row ofstaples 22 or onestaple holding strip 24, where thestaples 22 are arranged in a substantially linear row. Alternately,staples 22 or staple strips 24 may be arranged in two or more rows, parallel or otherwise, on one ormore arms 40. Alternately, thestaples 22 may be staggered on one or more arms, such that at least one row ofstaples 22 does not fall along a straight line. Thestaples 22 or staple strips 24 may be arranged or aligned in any manner on eacharm 40 that results in a secure anastomosis between the graft vessel and the target vessel. Thestaples 22 are inserted through the flaps at the end of thegraft vessel 32, or another portion of the target vessel, and into thetarget vessel 30 by pivoting thearms 40 of thestaple holder 38 towards theanvil arm 14. The staple bending features 16 are positioned in a configuration corresponding to the configuration of thestaples 22, such that each staple 22 engages a correspondingstaple bending feature 16 during deployment. When the ends of thestaples 22 engage the staple bending features 16 on theanvil arm 14, the ends of thestaples 22 are bent over, securing thegraft vessel 32 andtarget vessel 30 together. Once the staple ends are bent over, thestaples 22 are released from thestaple holding strip 24 or thestaple holder 38, resulting in spaced apartstaples 22 securing thegraft vessel 32 and thetarget vessel 30 together as shown inFIG. 6 . Alternately, thestaple holder 38 is a mechanism that deploys connectors other than or in addition tostaples 22. - After stapling is complete, an incision is formed in the wall of the
target vessel 30 to allow blood flow between the target vessel and thegraft vessel 32. Some examples of methods and devices for forming the incision will be described in further detail below.FIG. 6 illustrates a completed anastomosis between atarget vessel 30 and agraft vessel 32 with a plurality ofstaples 22. The spacing between thestaples 22 is approximately 1 to 4 mm. This spacing is similar to the spacing between sutures in a conventional sutured anastomosis. A different spacing between thestaples 22 may be used if desired. After completion of the anastomosis, theanvil arm 14 is withdrawn from thetarget vessel 30 betweenadjacent staples 22. The withdrawal of theanvil arm 14 leaves a gap that is approximately the same as the spacing between adjacent staples. Accordingly, substantially no blood leakage occurs at the location where the anvil arm has been withdrawn. -
FIGS. 7 and 8 illustrate one example of a staple 22 connected to astaple holding strip 24. Thisstaple 22 includes barbed staple ends 52 extending from the front portion of the staple 22 and a C-shapedportion 54 extending from a rear of the staple 22 for connecting the staple 22 to thestaple holding strip 24. Thestaple holding strip 24 includes a plurality ofprotrusions 56 for receiving thestaples 22. The C-shapedportion 54 of each staple 22 is received around one of theprotrusions 56 and is secured in place at one or more locations, such as bywelds 58 or by a frangible linkage or connection. Alternately, the C-shapedportion 54 of each staple 22 may be secured to the staple-holdingstrip 24 in a different way. As shown inFIG. 8 , when thestaple holding strip 24 is advanced toward theanvil arm 14, the barbed staple ends 52 are received in therecesses 20 in theanvil arm 14. Contact between eachstaple end 52 and thecorresponding recess 20 generates a moment that causes the barbed staple ends 52 to bend towards one another. At the same time that the barbed staple ends 52 bend over, or after the bending of the staple ends 52, thestaple 22 is detached from thestaple holding strip 24. The staple 22 may be detached from thestaple holding strip 24 by the action of bending the barbed staple ends 52 such that the C-shapedportion 54 of the staple 22 splays outward and breaks apart from the correspondingprotrusion 56 on thestaple holding strip 24, by bending a frangible connection between the staple holding strip and the staples to separate the staples, or any other known separation methods, such as melting of a connection between the staple and the staple holding strip. -
FIG. 9 illustrates analternate staple 22 a having inwardly curved barbed staple ends 52 a. Because the staple ends 52 a are themselves curved, the corresponding staple bending feature or features 16 a need not be curved to bend the ends 52 a of thestaples 22 a. As shown inFIG. 9 , the staple bending features 16 a on each side of the anvil arm 14 a may be formed as a single longitudinal groove along the anvil arm 14 a, where the staple bending feature 16 a has a substantially flat surface. When the curved ends 52 a of the staple 22 a are received in the groove 16 a of the anvil arm 14 a, the ends bend inward to secure the tissue with the staple. Alternately, the staple may be configured differently. Alternately, two or more different kinds of staples are deployed by thestaple holder 38 in order to form a single anastomosis. - Referring also to
FIG. 10A , a plurality ofstaples 22 a are positioned on an expandable staple holding strip called anexpandable backbone 66. Theexpandable backbone 66 includes a plurality ofelements 68 which are interconnected by one or more expandingmembers 70. Each of thebackbone elements 68 is provided with a connectingdiamond member 72 that is connected to one of thestaples 22 a. As shown inFIG. 10A , each staple 22 a is connected to thecorresponding diamond member 72 by a thin connectingsection 74. Theexpandable backbone 66 allows the spacing between thestaples 22 a to be adjusted for the particular anastomosis to be performed. Thebackbone 66 allows expansion of the distance between staples from a distance of approximately 0.1 mm to a distance of approximately 1 to 4 mm, i.e., expansion of up to 40 times the original spacing. Alternately, thebackbone 66 allows a different amount of expansion. The expandingbackbone 66 also includes twoopenings 76 at opposite ends which may be engaged by holding pins (not shown) on an anastomosis system or staple holder. Theopening 76 allow thebackbone 66 to be easily expanded by relative motion of the holding pins. The connectingdiamond members 72 are configured to collapse inwardly toward the backbone when thestaples 22 a engage the staple bending surface or surfaces 16 a of the anvil. The collapsing of eachdiamond member 72 forces the correspondingstaple 22 a to separate from thediamond member 72 at a connectingsection 74. The connectingsection 74 is a frangible linkage connecting a staple 22 a to acorresponding diamond member 72. -
FIG. 10B illustrates another example ofstaples 22 a detachably connected to abackbone 66. Thestaples 22 a are each connected to the associatedbackbone elements 68 at two connectingsections 74. Thestaples 22 a,backbone 66, and associated components are substantially as described above with regard toFIG. 10A . -
FIG. 11 shows a portion of ananvil arm 14 with amovable cutting device 44. The cuttingdevice 44 includes abase 46 and ablade 48. Thebase 46 of the cuttingdevice 44 is positioned in alongitudinal groove 50 in theanvil arm 14. After theanvil arm 14 has been inserted into the target vessel, the cuttingdevice 44 may be moved longitudinally along theanvil arm 14 to form an incision in the target vessel. -
FIGS. 12 , 12A, and 12B illustrate external cutting devices that are advanced down onto theanvil arm 14 after the anastomosis procedure and cut an incision in the target vessel from an exterior of the target vessel as theanvil arm 14 is withdrawn. As shown inFIG. 12 , aknife 62 is positioned on aknife arm 64 that is movable along thehandle 12 of the anvil. Theknife 62 is moved downward in a direction substantially parallel to the longitudinal axis of thehandle 12 until theknife 62 engages arecess 65 in theanvil arm 14. Theknife 62 is thereby positioned substantially at the anastomosis site. The end of the graft vessel is then placed substantially against the wall of the target vessel at the anastomosis site, over theknife 62 andknife arm 64. As theanvil arm 14 is withdrawn from the anastomosis site, theknife 62 forms an incision in the target vessel. Theknife 62 andknife arm 64 exit the anastomosis site via the joint between the graft vessel and the target vessel. The withdrawal of theanvil arm 14,knife 62 andknife arm 64 leaves a gap in the wall of the target vessel that is approximately the same as the spacing between adjacent staples to minimize or eliminate leakage through that gap. Alternately, theknife 62 may be moveable relative to thehandle 12 in at least one direction in addition to a direction substantially parallel to the longitudinal axis of thehandle 12. For example, theknife 62 may be moveable in a direction substantially parallel to the wall of the target vessel to create an arteriotomy in the target vessel at the junction between the graft vessel and the target vessel. -
FIGS. 12A and 12B illustrate two alternate examples of theknife 62 which snap onto acorresponding engagement surface 65 of theanvil arm 14 so that the knife and anvil are secured together for formation of the incision during removal of theanvil arm 14 from the anastomosis site. -
FIGS. 13-16 illustrate two variations of extendable cutting devices for making an incision in the target vessel while withdrawing theanvil arm 14 from the target vessel.FIG. 13 illustrates ananvil arm 14 b having ablade 78 connected to aflexible blade support 80. When theblade support 80 is pulled in the direction of the arrow A with respect to theanvil arm 14 b, theblade 78 moves from a forwardly extending position shown inFIG. 13 to an upwardly extending position shown inFIG. 14 as a result of flexure of theblade support 80. Theblade 78 in the forwardly extending position may be used to form a small opening in the wall of the target vessel through which theanvil arm 14 is inserted into the target vessel. After an anastomosis has been performed, or while an anastomosis is performed, theblade 78 is moved to an upwardly angled or a vertical position in which theblade 78 is used to form an incision in the target vessel as theanvil arm 14 b is removed from the target vessel. -
FIGS. 15-16 illustrate an alternate example of ananvil arm 14 c having ablade 84 and ablade support 86. While theanvil arm 14 c is inserted into the target vessel and during the anastomosis procedure, theblade 84 is positioned in arecess 88 in the anvil arm. Theblade 84 may be moved from the position ofFIG. 15 to the extended position ofFIG. 16 by moving theblade support 86 in the direction of the arrow B with respect to the anvil arm. Theblade 84 is flexible and stressed, such that freeing theblade 84 from therecess 88 causes theblade 84 to move to the extended position. Alternatively, theblade 84 may be extended automatically upon withdrawal of theanvil arm 14 when ablade tip 90 catches on an interior surface of the target vessel wall during withdrawal of the anvil arm. - The extendable cutting devices shown in
FIGS. 13-16 are merely shown as examples of the type of cutting devices which may be used for making the incision. Once these cutting devices or blades have been extended from the anvil arm, they may be fixed to perform cutting as the anvil arm is removed from the target vessel or the blades may be movable along the anvil arm to make an incision prior to removal of the anvil arm from the target vessel. - Referring to
FIG. 55 , anexemplary anastomosis tool 300 is shown. Theanastomosis tool 300 includes ahandle 302, ashaft 304 connected to thehandle 302, acable housing 306 connected at one end to thehandle 302, and atissue effector 400 connected to both theshaft 304 and thecable housing 306. Theanastomosis tool 300 may be configured differently, if desired. For example, thecable housing 306 may be omitted, and the cable or cables (not shown) that would otherwise extend therethrough are instead routed through theshaft 304. Thehandle 302 and/or thetissue effector 400 may be detachable from theshaft 304 to allow for interchangeability of these components. In this way, thesame handle 302 may be used to perform more than one anastomosis within a single patient, where adifferent tissue effector 400 may be connected to that handle 302 for each anastomosis. Further, thehandle 302 may be constructed from materials that can be sterilized, such as by an autoclave, and reused. Thehandle 302 may assume any appropriate configuration; the shape and configuration of thehandle 302 described herein is exemplary and not limiting. Theshaft 304 may be a rigid hollow structure such as a tube of stainless steel, but may be shaped differently and/or fabricated from a different material. Further, theshaft 304 may be flexible at least in part, rather than rigid. Alternately, theshaft 304 may be omitted altogether, such that thehandle 302 is connected to thetissue effector 400 by one or more cables that would otherwise have extended through theshaft 304. Thehandle 302 includes atrigger 308 that provides for actuation of theanastomosis tool 300 based solely on a single input to thattrigger 308, as described in greater detail below. Alternately, additional inputs may be utilized to actuate theanastomosis tool 300. For example, actuation of theanastomosis tool 300 may be based on an input to one or more buttons in addition to thetrigger 308. - The
tissue effector 400 includes ananvil 10 and astaple holder 38. Thetissue effector 400 may be permanently fixed to theshaft 304, or may be detachable from it such that is it decoupled from thehandle 302. That is,tissue effectors 400 may be interchangeable. Alternately, theshaft 304 is not provided, and thetissue effector 400 is directly coupled to thehandle 302. One end of thecable housing 306 is fixed to thestaple holder 38. - The
anvil 10 of thetissue effector 400 may be as described above, or may be configured differently. Advantageously, theanvil 10 also includes acutter 200 that is moveable relative to theanvil 10 for making an incision in the wall of a target vessel. Referring toFIGS. 34 and 35 , atissue stop 220 is formed into or connected to theanvil 10. The portion of theanvil 10 distal to thetissue stop 220 is configured to penetrate into the wall of a target vessel, and may be referred to as theanvil arm 14. Achannel 246 is defined within theanvil arm 14, through which acutter 200 is configured to move. Thecutter 200 is narrower than thechannel 246, such thatinterior surfaces 202 on either side of thechannel 246 may guide the translation of thecutter 200 relative to theanvil arm 14. As used in this document, the term “translation” as used in regard to thecutter 200 refers to motion of thecutter 200 in the distal or proximal direction, whether or not thecutter 200 or a portion thereof moves upward or downward during that motion. For convenience, the direction substantially perpendicular to the longitudinal centerline of theanvil arm 14 toward the wall of the target vessel may be referred to as “upward”, and the direction substantially perpendicular to the longitudinal centerline of theanvil arm 14 away from the wall of the target vessel may be referred to as “downward”. However, the positioning of theanvil arm 14 in use is not limited to an orientation in which these directions correspond to absolute directions measured relative to the ground. Similarly, for convenience, motion upward or downward may be referred to as “vertical” motion, and motion substantially parallel to the longitudinal centerline of theanvil arm 14 may be referred to as “horizontal” motion. - The
anvil arm 14 includes acontact surface 206. Referring also toFIG. 36 , in use, thecontact surface 206 of theanvil arm 14 is placed substantially against theinner surface 203 of atarget vessel 201. Thecontact surface 206 substantially defines a place that is substantially parallel to the longitudinal centerline of theanvil arm 14. Alternately, thecontact surface 206 is contoured and/or oriented differently. Anupper opening 248 extends along at least a portion of thecontact surface 206 in a direction substantially parallel to the longitudinal centerline of theanvil arm 14, and opens into thechannel 246. Theupper opening 248 may divide thecontact surface 206 into symmetrical or asymmetrical sections. Further, thecontact surface 206 may be formed by two substantially planar surfaces, by one substantially planar surface and a differently-shaped surface, or by another set of surfaces. Additionally, thecontact surface 206 may be formed by two thin edges, each edge occurring at the intersection of a wall of theupper opening 248 and an outer surface of theanvil arm 14. Theupper opening 248 need not extend proximally any further than thetissue stop 220. However, theupper opening 248 may extend proximal to thetissue stop 220, if desired. A firstlower opening 254 and a secondlower opening 268 are defined through alower surface 256 of theanvil arm 14. Thelower surface 256 of theanvil arm 14 may be substantially parallel to thecontact surface 206 or may be oriented differently relative to thecontact surface 206. Alternately, the firstlower opening 254 and/or the secondlower opening 268 do not extend completely through theanvil arm 14, and instead are depressions extending along at least part of abottom surface 266 of thechannel 246. - Referring also to
FIGS. 37-38 , thecutter 200 is a thin, rigid member, shaped such that it can be held within thechannel 246 in theanvil arm 14. Thecutter 200 has a substantially constant width along its entire length. Alternately, the width of thecutter 20 may vary along its length. Thecutter 200 may be made of metal, ceramic, plastic, or other material, or from a combination of different materials. Asharp projection 208 extends upward from thecutter 200 at or near its distal end. Theprojection 208 is substantially triangular, but may be shaped differently. Theprojection 208 may be smooth or serrated, or otherwise shaped or formed. A portion of theprojection 208 may be ground or otherwise honed to a sharp edge to facilitate the motion of theprojection 208 through the tissue of the wall of a target vessel, as described in greater detail below. If so, thecutter 200 is composed of a material that can be sharpened adequately to cut tissue. Alternately, thecutter 200 may be flexible, at least in part. Further, theprojection 208 may be located at a different position on thecutter 200 than at or near its distal end. An additional sharp point (not shown) may be provided at the distal end of thecutter 200, extending in a distal direction, in order to create an initial puncture or incision in the wall of the target vessel. Such a point may be as described in U.S. patent application Ser. No. 10/134,081, which is herein incorporated by reference in its entirety. - One or more
additional projections 208 may be provided, if desired. For example, two ormore projections 208 may extend upward from thecutter 200. Wheremultiple projections 208 are used, they may cooperate with one another to create an incision in the wall of the target vessel. Referring also toFIG. 39 , asecond projection 208 extends upward from thecutter 200 proximal to afirst projection 208. Theprojections 208 are both substantially the same triangular shape and the same size. However, theprojections 208 may be shaped and sized differently. Theprojections 208 are both substantially planar, and are aligned such that bothprojections 208 lie in substantially the same plane. Eachprojection 208 may include at least one sharpened orbeveled edge 209 oriented to engage and incise the wall of the target vessel when thecutter 200 is translated, as described below. Referring toFIG. 40 , at least twoprojections 208 extend upward from thecutter 200. Theprojections 208 each have abarb 211 at the tip. However, thebarb 211 may be omitted from some or all of theprojections 208. Under thebarb 211, a sharpened orbeveled edge 209 extends downward and proximally. Theedge 209 may be straight or curved. The upper end of theedge 209 is distal to the lower, proximal end of the corresponding barb. Theedge 209 of eachprojection 208 is oriented to engage and incise the wall of the target vessel when thecutter 200 is translated. Referring toFIG. 41 , at least twoprojections 208 extend upward from thecutter 200, at least one of which has abarb 211 at its tip. Theedge 209 associated with eachprojection 208 is more curved than theedge 209 shown inFIG. 40 . Alternately, theedge 209 is substantially straight, or gently curved, or positioned on a portion of a largercurved segment 213 extending downward from and proximal to thebarb 211. Referring toFIG. 42 , a number ofprojections 208 may be placed along a length of thecutter 200. This length may be comparable to the desired length of the incision in the wall of the target vessel. Theseprojections 208 may be substantially triangular as shown, or may be shaped differently. Where more than oneprojection 208 is used on thecutter 200, theprojections 208 need not have the same configuration. For example,projections 208 such as theexemplary projections 208 shown inFIGS. 39-41 may be mixed together on thesame cutter 200. Alternately, one or more of theprojections 208 are moveable relative to thecutter 200, such that one ormore projections 208 can be moved upward or downward relative to thecutter 200. - As another example of a configuration of the
projections 208, referring toFIG. 43 , theprojections 208 extending upward from thecutter 200 each are substantially planar, and are aligned such that not all of theprojections 208 lie in the same plane. In such a configuration, theprojections 208 may create a wider incision in the wall of the target vessel than would be created if theprojections 208 were substantially aligned. For example, one set ofprojections 208 may be aligned substantially in a first plane, and a second set ofprojections 208 may be aligned substantially in a second plane substantially parallel to the first plane. The second plane and the first plane may be oriented differently relative to one another, if desired. As another example, none of theprojections 208 lie in a common plane with one or moreother projections 208. Referring toFIGS. 39-42 , by using multiple projections, thecutter 200 need not be translated as far to make an incision in the wall of the target vessel as it would if only asingle projection 208 were used, as described in greater detail below. - Referring back to
FIGS. 34-35 , aninterior surface 202 is located on each side of thechannel 246. Eachinterior surface 202 may be substantially planar, curved, or may be shaped differently. Further, eachinterior surface 202 may be oriented at an angle to vertical or substantially vertical. The interior surfaces 202 may be formed such that thechannel 246 is substantially bilaterally symmetrical, or may be formed to result in achannel 246 that is not bilaterally symmetrical. The interior surfaces 202 of thechannel 246 within theanvil arm 14 may include raisedfeatures 204 that correspond to depressed staple bending features (not shown) on the outer surface of theanvil arm 14. That is, if the staple bending features are stamped into theanvil arm 14, or formed in another way that causes deformation of theanvil arm 14, the depressed staple bending features result in corresponding raised features 204 on theinterior surface 202 of thechannel 246. The raised features 204 do not interfere with the motion of thecutter 200 through thechannel 246. Alternately, the raised features 204 are not present on theinterior surface 202 of thechannel 246. - Optionally, a
safety feature 210 may be connected to the underside of theanvil 10. Thesafety feature 210 is biased toward theanvil 10 and thecutter 200. Thesafety feature 210 may be biased into thechannel 246 within theanvil 10. Alternately, thesafety feature 210 is connected to a different location, such as the underside of theanvil arm 14. Thesafety feature 210 may be flexible or rigid. Thesafety feature 210 includes atip 212 that is oriented substantially transverse to the longitudinal centerline of thecutter 200. Alternately, thetip 212 may be oriented in a different direction. If thesafety feature 210 is provided, thecutter 200 may include asafety recess 214 defined in it, corresponding to thetip 212 of thesafety feature 210. Thetip 212 is shaped and sized such that it can engage thesafety recess 214. Thetip 212 may be a bar or rod oriented substantially transverse to the direction of translation of thecutter 200, or may be shaped or oriented differently. - In
FIG. 34 , thestaple holder 38 has not yet been moved into position to perform anastomosis. In this position, if thesafety feature 210 is provided, thetip 212 of thesafety feature 210 is biased upward to engage thesafety recess 214. The engagement between thesafety recess 214 and thetip 212 of thesafety feature 210 substantially prevents translation of thecutter 200 within thechannel 246. Thus, thecutter 200 and theprojection 208 are prevented from deploying until thestaple holder 38 has been moved into the appropriate position relative to theanvil arm 14, and inadvertent deployment of thecutter 200 is prevented. - The
cutter 200 includes anengagement member 216 extending upward from a location at or near its proximal end. Theengagement member 216 instead may extend downward from thecutter 200 or to the side of thecutter 200. Further, theengagement member 216 may be positioned at a location other than at or near the proximal end of thecutter 200. Theengagement member 216 is configured to engage at least a portion of acorresponding receiver 218 in thestaple holder 38. Thus, after engagement between theengagement member 216 and thereceiver 218, translation of thereceiver 218 results in translation of thecutter 200. Thereceiver 218 is a structure that is at least partially open on its underside and that includes at least onesurface 219 configured to engage theengagement member 216. As shown inFIG. 34 , thesurface 219 is a partially-curved surface shaped to receive the curved upper end of theengagement member 216. However, thereceiver 218 may be a flat vertical surface, a curved surface, a structure such as an inverted cup that is open on its underside and that has a wall or walls encircling theengagement member 216, or any other structure or mechanism capable of engaging theengagement member 216 and urging it distally. Referring also to FIGS. 58 and 68-69, thereceiver 218 may be defined in asled 482, which is described in greater detail below. - An
anvil insert 222 is fixed to theanvil 10. As one example, theanvil 10 is wider proximal to theanvil arm 14, open at its top with a space therein. Theanvil insert 222 can be inserted into theanvil 10 through its top, such that theanvil insert 222 is partially or completely positioned within theanvil 10. However, theanvil insert 222 may be connected to theanvil 10 in another way. Alternately, theanvil insert 222 is connected to and capable of motion relative to theanvil 10. Further, theanvil insert 222 instead may be connected to the proximal end of theanvil arm 14, or another location on theanvil arm 14. Acavity 228 is defined within theanvil insert 222. Anaperture 230 is defined through the distal end of theanvil insert 222 into thecavity 228, connecting thechannel 246 in theanvil arm 14 andanvil 10 to thecavity 228. Thecutter 200 extends through theaperture 230, such that the distal end of thecutter 200 is positioned within thechannel 246 and the proximal end of thecutter 200 is positioned within thecavity 228. - A
cutter stop 236 may be formed into or connected to theanvil insert 222, or formed into or connected to theanvil 10 itself or another structure or mechanism. Thecutter stop 236 may engage the proximal end of thecutter 200 if thecutter 200 is moved to a defined position within thecavity 228, thereby restricting its proximal translation. Acavity 262 may be defined within thestaple holder 38 or a separate component connected to thestaple holder 38. Apost 258 is positioned at the upper end of thecavity 262, where thepost 258 is oriented downward. A biasingelement 260 is connected at one end to thepost 258. The biasingelement 260 may be a coil spring, a leaf spring, a different type of spring, an elastomer, a wire form, or other structure or mechanism capable of exerting a biasing force. The biasingelement 260 is positioned within and protected by thecavity 262, where thecavity 262 is used. Thecavity 262 may be a cylindrical opening having a diameter substantially the same as the outer diameter of the biasingelement 260, such that thecavity 262 restricts the biasingelement 260 to motion substantially along the axis of thecavity 262 and thus directs the force exerted by the biasingelement 260 in a substantially downward direction, preventing bending or other undesirable motion of the biasingelement 260. The end of the biasingelement 260 that is not connected to thepost 258 contacts thecutter 200. As an example, the biasingelement 260 may be a compression spring that is compressed between thepost 258 and thecutter 200, resulting in a force on thecutter 200 that biases thecutter 200 downward. Thecutter 200 is slidable relative to the biasingelement 260, such that the biasingelement 260 exerts a downward force on thecutter 200 at different locations along itsupper surface 252 as thecutter 200 translates. Thus, at least the distal end of thecutter 200 is biased downward throughout its translation along theanvil 10. Theentire cutter 200 may be biased downward, if desired. Alternately, thepost 258 is omitted, and the biasingelement 260 is fixed to an upper surface of thecavity 260. Alternately, the biasingelement 260 is omitted, and thecutter 200 is biased downward in another way. For example, thecutter 200 may be constructed from an elastic or superelastic material that is formed in such a way as to produce a downward bias. - Referring also to
FIG. 56 , theanvil 10 may include one or more attachment features 270. The attachment features 270 provide a location for attachment of one or more cables or other force transmission structures or mechanisms. As one example, the attachment features 270 may be one ormore passages 270 through thecutter stop 236. Thecutter stop 236 may include two or more spaced-apart members. If so, the attachment features 270 may be substantially aligned with one another, or offset from one another. However, thecutter stop 236 may be a single member, if desired. As another example, one or more of the attachment features 270 are separate from thecutter stop 236, and are positioned at a different location on theanvil 10. As another example, one or more of the attachment features 270 may extend in a direction from theanvil 10 that is other than upward. - The configuration of the attachment features 270 is related to the configuration of the cable or other force transmission structure or mechanism attached to it, such that the connection between them is secure. As one example, the
cutter stop 236 includes two spaced-apart members, and the attachment features 270 are passages through the upper portion of each member of thecutter stop 236. Two separate cables are connected to the attachment features 270. The end of each cable is passed through one of the attachment features 270, after which it is welded, connected with adhesive, clamped, tied or otherwise secured to thecutter stop 236. Alternately, a single first cable is passed through each of the attachment features 270, such that the free ends of the first cable are spaced apart from the attachment features 270. In this way, no additional steps are needed to secure the first cable to the attachment features 270. However, the cable may be welded, connected with adhesive, clamped, tied or otherwise secured to thecutter stop 236, if desired. - Referring also to
FIG. 44 , theanvil 10 extends proximally to a pivot point such as apin 226. The pivot point may be any other structure or mechanism that allows theanvil 10 to rotate about it. Alternately, theanvil insert 222 extends to thepin 226 instead of or in addition to theanvil 10. Thepin 226 pivotally connects thestaple holder 38 to theanvil 10. Thepin 226 may be formed into or otherwise fixed to thestaple holder 38 oranvil 10, if desired. Theanvil 10 and/oranvil insert 222 may extend still further proximally from thepin 226. As one example, theanvil 10 extends proximally to thepin 226. Theanvil insert 222 also extends proximally to thepin 226, and additionally extends as far as or further proximally to the proximal end of theanvil 10. - Referring also to
FIG. 57 , a proximal portion of theanvil insert 222 may be bent upward relative to a distal portion of theanvil insert 222. The proximal portion of theanvil insert 222 may be referred to as the spine 272. The spine 272 need not be bent upward relative to the proximal portion of theanvil insert 222, and instead may be bent downward or oriented substantially parallel to the proximal portion of theanvil insert 222. Alternately, the spine 272 is a separate structure or mechanism that is connected to theanvil insert 222. Apost 274 may be defined in or connected to the spine 272. Thepost 274 may be cylindrical, or may be shaped differently. One end of aspring 276 is connected to thepost 274. Thespring 276 is a coil spring, but may be a different type of spring if desired. The other end of thespring 276 is connected to thestaple holder 38, such as to anattachment member 275 defined in or connected to thestaple holder 38. Theattachment member 275 may be cylindrical, or may be shaped differently. Thespring 276 may be connected to thepost 274 and to theattachment member 275 by hooking an end of thespring 276 to each, by welding, by adhesive, or by any other appropriate structure, mechanism or method. Thespring 276 may be connected to thestaple holder 38 and/or the spine 272 in a different way, if desired. Thespring 276 is sized and configured to be in tension, so as to bias thetissue effector 400 to an open position. That is, thespring 276 presses thestaple holder 38 about thepin 226, toward the spine 272 of theanvil insert 222. - Optionally, one or
more buttons 278 are connected to the spine 272. The wing orbuttons 278 may be spaced apart from the spine 272 and connected to it by one ormore connection members 280. Thebuttons 278 each may be sized and shaped for contact with a user's finger. For example, twobuttons 278 may be sized and shaped such that a user may conveniently press one with a thumb and the other with a forefinger. The precise shape and size of thebuttons 278 is not critical to the invention. Optionally, at least onebutton 278 is connected to acog 282 that in turn connects to theshaft 304 of theanastomosis tool 300, as described in greater detail below. Thecog 282 includes one ormore teeth 284. Advantageously, thecog 282 is substantially circular, and theteeth 284 extend substantially radially outward from it. - Referring to
FIG. 58 , the underside of thestaple holder 38 is seen. Thestaple holder 38 includes twoarms 402, where thosearms 402 are spaced apart from one another at least at one end. More orfewer arms 402 may be provided. Thearms 402 extend distally from the remainder of thestaple holder 38. However, thearms 402 may be positioned differently, if desired. Thearms 402 are generally linear in configuration, and the longitudinal centerlines of thearms 402 are substantially parallel to one another. However, thearms 402 may be shaped differently and/or oriented differently relative to one another. One or more of thearms 402 may be angled relative to a horizontal plane to facilitate connecting the flaps of the graft vessel to the wall of the target vessel. Referring also toFIG. 59 , thearms 402 are spaced apart from one another at least at one end to allow agraft vessel 404 to be placed between them, and to allow thetissue effector 400 to be freed from the completed anastomosis. - The underside of each
arm 402 includes aflap receiving surface 406. Eachflap receiving surface 406 is substantially flat across at least a portion of its area. Eachflap 408 at the end of thegraft vessel 404 is placed onto a correspondingflap receiving surface 406, and the main body of thegraft vessel 404 extends between thearms 402 of thestaple holder 38. Advantageously, eachflap 408 is substantially flat against the correspondingflap receiving surface 406. One or more of theflap receiving surfaces 406 may include a ridgedregion 413 that hasindividual ridges 416 spaced apart from one another. Theindividual ridges 416 may be parallel to one another, or oriented differently. Theridges 416 extend away from theflap receiving surface 406. As one example, eachflap receiving surface 406 includes a ridgedregion 413 in proximity to its inner edge. As used in this document in the context of thestaple holder 38, the term “inner” refers to proximity to the space between thearms 402, and the term “outer” refers to distance from the space between thearms 402. - Advantageously, two
flaps 408 are present at the end of thegraft vessel 404. Theseflaps 408 may be created in any appropriate manner, such as by incising the end of thegraft vessel 404 with a scalpel. However, the end of thegraft vessel 404 may have more than twoflaps 408. Further, the end of thegraft vessel 404 may have asingle flap 408. That is, a single incision may be made at the end of thegraft vessel 404, substantially parallel to its centerline. As a result, asingle flap 408 is created that extends substantially continuously around the circumference of the end of thegraft vessel 404, where the opposite ends of theflap 408 are adjacent to the incision. - Optionally, one or
more spikes 410 may extend outward from at least one of the flap receiving surfaces 406. As at least one of theflaps 408 is placed onto the correspondingflap receiving surface 406, one or more of thespikes 410 penetrate thatflap 408 partially or completely, thereby assisting in holding theflap 408 in place against theflap receiving surface 406. - A
graft clip 412 is connected to eacharm 402. Eachgraft clip 412 may be configured to rotate relative to thecorresponding arm 402. As one example, eachgraft clip 412 is pivotally connected to thecorresponding arm 402 at or near theouter edge 414 of thatarm 402. Alternately, at least onegraft clip 412 is movable relative to thecorresponding arm 402 in a different way, such as by sliding. Alternately, at least onegraft clip 412 is initially a separate component from thearm 402, and is connectable to thecorresponding arm 402. Eachgraft clip 412 is moveable between an open position and a closed position relative to thecorresponding arm 402. Thegraft clip 412 is positioned relative to theflap receiving surface 406 on thecorresponding arm 402 such that, in the closed position, thegraft clip 412 is configured to engage aflap 408 of thegraft vessel 404. Thegraft clip 412 may engage substantially all of theflap 408, or less than all of theflap 408. Optionally, thegraft clip 412 may includeridges 416 corresponding toridges 416 extending from theflap receiving surface 406. - Alternately, the
spikes 410 alone hold theflaps 408 onto the correspondingflap receiving surfaces 406, and one or more graft clips 412 are not used. Thespikes 410 are oriented at an angle that facilitates the opening of thetissue effector 400 after theflaps 408 are connected to the target vessel. Where thespikes 410 alone hold theflaps 408, thevein knives 432 that are described below may be omitted, because thestaple holder 38 is disengaged from theflaps 408 simply by removal of thespikes 410 from theflaps 408. Thus, by eliminating the graft clips 412, construction of thetissue effector 400 may be simplified. Alternately, a structure or mechanism other than or in addition to thespikes 410 may be used to hold theflaps 408 onto the corresponding flap receiving surfaces 406. - Each
graft clip 412 is locked or otherwise held in the closed position to securely hold theflap 408 between itself and the correspondingflap receiving surface 406. The pressure between thegraft clip 412 and theflap receiving surface 406, alone or in conjunction withridges 416 on thegraft clip 412 and theflap receiving surface 406 and/orspikes 410 extending upward from the flap receiving surface, holds theflap 408 firmly in place. Thespikes 410, if used, may engage thegraft clip 412 when it is in the closed position. Theridges 416 on thegraft clip 412 and theflap receiving surface 406, if used, engage opposite sides of at least oneflap 408, thereby gripping theflap 408 firmly and resisting motion of theflap 408 in a direction substantially perpendicular to the orientation of theridges 416. However, eachgraft clip 412 may be shaped or configured in any manner that allows it to participate in holding thecorresponding flap 408 to the correspondingflap receiving surface 406. - The
graft clip 412 may be locked or otherwise held in the closed position with any appropriate mechanism, structure or method. As one example, thegraft clip 412 uses a cam lock to hold itself in the closed position. Referring also toFIG. 59A , thegraft clip 412 is in an open position. In the open position, thegraft clip 412 is positioned to receive aflap 408 of thegraft vessel 404 between it and theflap receiving surface 406. Thegraft clip 412 is rotatable about anaxle 418 that is spaced apart from awall 420 defined on anarm 402 of thestaple holder 38. Thewall 420 may be perpendicular or otherwise angled to theflap receiving surface 406. Theaxle 418 is connected to thearm 402, and is substantially fixed relative to thewall 420. Alternately, theaxle 418 is movable relative to thewall 420. Theaxle 418 extends substantially longitudinally, but may be angled relative to the longitudinal direction. Thearm 402 also includes anoverhang 586 that extends outward and downward from the main portion of thearm 402. Alternately, theoverhang 586 extends in a different direction. Theoverhang 586 may extend laterally outward at least as far as the longitudinal centerline of theaxle 418, but need not do so. - The
graft clip 412 includes alobe 422 in proximity to theaxle 418, where thelobe 422 has a non-circular cross section. Thelobe 422 has a variable thickness, where thickness is defined as the distance between the surface of theaxle 418 and the surface of thelobe 422. Thelobe 422 includes afirst portion 588 that has a relatively small thickness. When thegraft clip 412 is in the open position, thefirst portion 588 is substantially adjacent to theoverhang 586. The thickness of thefirst portion 588 of thelobe 422 is substantially equal to the distance between theaxle 418 and theoverhang 586. Alternately, thefirst portion 588 of thelobe 422 may have a different thickness. Moving counterclockwise along thelobe 422, its thickness increases, then decreases rapidly to form astep 590, which may be substantially aligned with the centerline of theaxle 418. Continuing to move counterclockwise along thelobe 422, its thickness once again increases. Thegraft clip 412 may be a mirror image of theclip 412 shown inFIG. 59A , such that the thickness of thelobe 422 relative to the angular position thereon is reversed from the description above. Similarly, if thegraft clip 412 is viewed from the opposite direction, the thickness of thelobe 422 will be reversed from the description above. The operation of thegraft clip 412 is the same. - In the open position, which is the initial position of the
graft clip 412, thefirst portion 588 of thelobe 422 is adjacent to theoverhang 586. Thisfirst portion 588 may be substantially as thick as the distance between theaxle 418 and theoverhang 586. The portion of thelobe 422 adjacent to and immediately clockwise from thestep 590 may be in contact with or in proximity to thewall 420. Thegraft clip 412 is rotated about theaxle 418 from the open position to the closed position in a clockwise direction by the user or by a mechanism associated with thetissue effector 400. As this rotation begins, increasingly-thick portions of thelobe 422 move between theaxle 418 and theoverhang 586. As a result, theoverhang 586,axle 418, and/orlobe 422 may flex to accommodate the increased amount of thickness of thelobe 422 between theaxle 418 and theoverhang 586. Further, this increase in thickness between theaxle 418 and the overhand 586 may provide at least some resistance to the motion of thegraft clip 412. - Referring also to
FIG. 60 , as the rotation of thegraft clip 412 continues, thestep 590 encounters theoverhang 586, then moves past theoverhang 586. As a result, the thickness of thelobe 422 between theoverhang 586 and theaxle 418 decreases abruptly. The stiffness of theoverhang 586 is such that theoverhang 586 can flex enough to allow thegraft clip 412 to rotate past thestep 590. Rotation of thegraft clip 412 may stop at or shortly after the motion of thestep 590 past theoverhang 586, such that thegraft clip 412 stops at the closed position shown inFIG. 59C . Motion of thegraft clip 412 in the counterclockwise direction would cause thestep 590 to encounter the end of theoverhang 586, stopping the rotation of thegraft clip 412. Thus, thestep 590 acts to hold thegraft clip 412 in the closed position. - Alternately, a structure or mechanism other than a cam lock may be used to hold the
graft clip 412 in a closed position. As one example, at least one elastic band (not shown) may be used to hold thegraft clip 412 against thestaple holder 38. Each elastic band may be fixed to either thegraft clip 412 or thestaple holder 38. As another example, thegraft clip 412 and thecorresponding arm 402 may each include corresponding magnets (not shown), such that magnetic force holds thegraft clip 412 in contact with thearm 402 in the closed position. - As another example, referring to
FIG. 60 , asnap arm 606 may be used to hold thegraft clip 412 in a closed position. Thesnap arm 606 is connected at one end to thecorresponding arm 402. This connection may be a hinge, or may be any other connection that allows thesnap arm 606 to move between an open position, in which thegraft clip 412 may be opened, and a closed position, in which thegraft clip 412 is held closed. The connection between the proximal end of thesnap arm 606 and thearm 402 is made proximal to theflap receiving surface 406. Alternately, the connection between thesnap arm 606 and thestaple holder 38 is made at a different location. Alternately, a different part of thesnap arm 606 than its proximal end is connected to thearm 402. - The distal end of the
snap arm 606 includes acatch 608 that is shaped to engage the distal end of thecorresponding arm 402. For example, thecatch 608 may be curved such that alobe 610 of thecatch 608 is proximal to the distal end of thearm 402 when thesnap arm 606 is in the closed position, thereby holding thesnap arm 606, and thegraft clip 412, in place. Thecatch 608 is at least partially flexible such that thecatch 608 can be snapped down onto the distal end of the corresponding arm, thereby holding thesnap arm 606 in the closed position. Thecatch 608 may be configured differently, if desired. When thesnap arm 606 is in the closed position, at least a portion of thegraft clip 412 is positioned between thesnap arm 606 and thecorresponding arm 402. Thus, in the closed position, thesnap arm 606 presses thegraft clip 412 against thearm 402, holding it in place. As a result, thegraft clip 412 holds thecorresponding flap 408 against theflap receiving surface 406. - Alternately, a
separate snap arm 606 is not used, and thegraft clip 412 itself includes acatch 608 that engages thecorresponding arm 402 of thetissue effector 400. Alternately, thesnap arm 606, or thegraft clip 412 that includes acatch 608, is oriented differently, such as described above with regard toFIGS. 59A-59B . - Referring also to
FIG. 61 , in the closed position, eachgraft clip 412 is configured to press aflap 408 of the target vessel against the correspondingflap receiving surface 406. Theflap 408 is not shown for clarity. In the closed position, thegraft clip 412 and theflap receiving surface 406 are substantially fixed relative to one another. Thegraft clip 412 and the correspondingflap receiving surface 406 may be configured such that a portion of each would contact the other in the closed position, absent theflap 408. Thus, where theflap 408 is present, thegraft clip 412 compresses theflap 408 against theflap receiving surface 406. Additionally, thegraft clip 412 may include anoverhang 424, which extends along at least a portion of the edge of thegraft clip 412. Theoverhang 424 may be substantially parallel to and in proximity to the correspondinginner edge 411 of thearm 402 in the closed position. Alternately, theoverhang 424 may be configured differently relative to thearm 402. Theoverhang 402 may bend theflap 408 and/or press, pinch or otherwise hold it against the corresponding edge of thearm 402. - Still referring to
FIG. 61 , afirst channel 426 may be defined in thegraft clip 412, and a correspondingsecond channel 428 may be defined in thearm 402. Thefirst channel 426 and thesecond channel 428 are substantially linear and substantially aligned with one another. Alternately, thefirst channel 426 and thesecond channel 428 are configured differently, aligned differently with respect to one another and/or have a different cross-section. Eachchannel first channel 426 and thesecond channel 428 are oriented and aligned relative to one another such that the openings in thechannels vein knife passage 430. Thechannels vein knife passage 430; that is, thevein knife passage 430 need not be bounded around its entire periphery. Alternately, thechannels vein knife passage 430 is formed differently. Eachvein knife passage 430 is oriented such that, when thetissue effector 40 is in the closed position, the longitudinal centerline of thevein knife passage 430 is substantially parallel to the longitudinal axis of theanvil 10. Alternately, thevein knife passages 430 are aligned differently relative to the longitudinal axis of theanvil 10 when thetissue effector 400 is in the closed position. - Referring also to
FIG. 62 , at least onevein knife passage 430 is configured to receive acorresponding vein knife 432. The fit between the dimensions of thevein knife 432 and the correspondingvein knife passage 430 is close enough that thevein knife passage 430 guides thevein knife 432 and substantially prevents wobbling or other disruption of the motion of thevein knife 432 as it travels along thevein knife passage 430, and loose enough to allow thevein knife 432 to slide easily along thatvein knife passage 430 substantially without binding or interference. Eachvein knife 432 has ablade 434 or other sharp element at its distal end. Theblade 434 of at least onevein knife 432 may be angled. Alternately, theblade 434 of at least one vein knife may be curved or otherwise shaped. The proximal end of eachvein knife 432 is connected to a sled, which is described in greater detail below. Thevein knife 432 is configured to translate or otherwise move between a first position and a second position. In the first position, theblade 434 of thevein knife 432 is located proximal to theflap 408 held between thegraft clip 412 and theflap receiving surface 406. Thevein knife 432 translates or otherwise moves to the second position and cuts theflap 408 as it does so. In the second position, theblade 434 of thevein knife 432 is located adjacent or distal to the portion of theflap 408 held between thegraft clip 412 and theflap receiving surface 406. The first and second positions are reversed when thevein knife 432 is moved in the opposite direction. - Optionally, one or more
graft clip blades 436 are connected to at least onegraft clip 412. Referring also toFIG. 63 , one or more of thegraft clip blades 436 may be serrated. Eachgraft clip blade 436 is located in and against one side of thefirst channel 426, such that it does not interfere with the motion of thevein knife 432. Alternately, one or moregraft clip blades 436 are located in a different position on thecorresponding graft clip 412 orarm 402.Serrations 438 on thegraft clip blade 436 are oriented toward the open face of thefirst channel 426 in thegraft clip 412. Theserrations 438 may be sized and shaped in any appropriate manner. Theserrations 438 assist in holding theflap 408 between thegraft clip 412 and theflap receiving surface 406. That is, one or more of theserrations 438 may penetrate into or through theflap 408, thereby holding the tissue of theflap 408 substantially fixed relative to thegraft clip 412 and theflap receiving surface 406. When thevein knife 432 translates along thevein knife passage 430 to incise theflap 408, theserrations 438 hold theflap 408. The motion of thevein knife 432 may apply stress to the tissue of theflap 408 such that theserrations 438 themselves act to cut the tissue of theflap 408. Thus, the cutting action may be a scissors-like action resulting from the relative motion of thevein knife 432 and thegraft clip blade 436. More than onegraft clip blade 436 can be provided in at least onevein knife passage 430. For example, twograft clip blades 436 may be located in onefirst channel 426, in and against two different sides of thefirst channel 426 and spaced apart from one another a sufficient distance to allow thevein knife 432 to slide therebetween. Other configurations or numbers ofgraft clip blades 436 may be utilized, if desired. - Alternately, referring to
FIG. 59D , at least onegraft clip 412 may have a thinner cross-section than thegraft clip 412 ofFIGS. 59-59B . This thinner cross-section may be achieved by utilizing metal, such as sheet metal, to form at least part of thegraft clip 412. However, metal need not be used in order for thegraft clip 412 to be made thinner. As shown inFIG. 59C , thegraft clip 412 may be an assembly having afirst piece 407 connected to asecond piece 409. Thefirst piece 407 is located at or near thefirst channel 426 of thegraft clip 412. Alternately, thegraft clip 412 may be a single-piece, or may be an assembly having additional components. Thesecond piece 409 may be made of plastic or any other suitable material. Other materials may be used to form thepieces graft clip blades 436 may be formed into thefirst piece 407, particularly where at least thefirst piece 407 of thegraft clip 412 is metal. By forming thegraft clip blades 436 into a portion of thegraft clip 412 rather than connecting them to thegraft clip 412, construction of thegraft clip 412 may be simplified. - The use of a
thinner graft clip 412 results in less compression of the surface of the heart, where the target vessel is a coronary artery and theanvil arm 14 is inserted into that coronary artery. The vertical distance between the bottom of theanvil arm 14 and the bottom of thegraft clip 412 substantially defines the distance across which the heart tissue near the coronary artery is compressed as thetissue effector 400 moves from the open to the closed position. By decreasing that distance, the heart tissue around the coronary artery is compressed a lesser distance. As a result, the amount of force required to move thetissue effector 400 from an open position to a closed position, in which compressive force is applied against the heart tissue, may be decreased. This reduction in force may simplify the construction of thetissue effector 400. - Referring also to
FIG. 64 , a cross-section of onearm 402 of thestaple holder 38 is shown. Thestaple holder 38 is substantially symmetrical, such that thearm 402 shown is substantially a mirror image of theother arm 402. Alternately, thestaple holder 38 is not symmetrical, and/or thearms 402 are not mirror images of one another. Apassage 440 is defined within eacharm 402. Eachpassage 440 extends substantially longitudinally within thecorresponding arm 402, and the longitudinal centerline of eachpassage 440 is substantially parallel to the longitudinal centerline of theanvil 10 when thetissue effector 400 is in the closed position. Alternately, at least onepassage 440 is oriented differently relative to itscorresponding arm 402. Thepassage 440 may have a rectangular cross-section, or a different cross-section. Further, the dimensions of thepassage 440 may be substantially constant along its entire length, or may change along at least part of its length. Optionally, thedistal end 442 of thepassage 440 is open, and/or theproximal end 444 of thepassage 440 is open. - A
ramp element 446 is configured to translate or otherwise move through at least a portion of eachpassage 440. Referring also toFIGS. 68-69A , theramp elements 446 may be molded or otherwise formed into a unitaryramp element assembly 484, or may be molded or otherwise formed separately and then connected together. Theramp elements 446 may be formed from stainless steel or other appropriate material. Thevein knives 432 are connected to theramp element assembly 484 to form asled 482. As an example,apertures 486 are defined in theramp element assembly 484, and the proximal end of eachvein knife 432 is sized and shaped to provide for a pressure or interference fit within the correspondingaperture 486. However, any other appropriate mechanism, structure or method may be used to connect eachvein knife 432 to theramp element assembly 484. Alternately, theramp elements 446 and thevein knives 432 are cast, molded or otherwise formed as a single unit. Thevein knives 432 are fixed to theramp element assembly 484, such that theramp elements 446 and thevein knives 432 translate as a unit substantially simultaneously. Alternately, at least oneramp element 446 is moveable relative to at least onevein knife 432. As another example of thesled 482, eachramp element 446 is connected to thecorresponding vein knife 432, but theramp elements 446 are not connected to one another. - The
sled 482 includes anattachment feature 488. Theattachment feature 488 may be an aperture through a portion of theramp element assembly 484 that is configured to receive asecond cable 490 or other force transmission mechanism or structure. Where a cable is used and theattachment feature 488 is an aperture, thesecond cable 490 may be inserted into and/or through theattachment feature 488, and held in place there such as by tying off one end of the cable, by welding, by adhesive, or any other appropriate connection method. Alternately, theattachment feature 488 may be a ring, a hook, a raised area, a depression, or any other structure or mechanism appropriate for connection to a cable or other force transmission mechanism or structure. - One or
more connector bays 448 are defined in eacharm 402, between thepassage 440 within thearm 402 and aninner surface 450 of thearm 402. Theconnector bays 448 and thepassages 440 are substantially hollow. The cross-sectional shape of eachconnector bay 448 is selected to allow it to receive and hold a staple, as described below. Theconnector bays 448 are oriented such that the longitudinal centerline of eachconnector bay 448 is substantially perpendicular to the longitudinal centerline of thecorresponding passage 440. Alternately, at least oneconnector bay 448 is oriented differently relative to thecorresponding passage 440. Eachconnector bay 448 has substantially the same cross-section and length. Alternately, at least oneconnector bay 448 has a different cross-section and/or length than at least oneother connector bay 448. Theconnector bays 448 may be oriented relative to a local horizontal such that the longitudinal centerline of eachconnector bay 448 forms an angle of between 0° and 45° relative to that local horizontal. A different orientation may be used, if desired. The use of the term “horizontal” here and elsewhere in this document is used for convenience in description only, and does not restrict the orientation in which theanastomosis tool 300 may be used. - Referring also to
FIG. 65 , at least oneconnector bay 448 is configured to receive aconnector deployer 452. Eachconnector bay 448 is shaped to allow thecorresponding connector deployer 452 to translate or otherwise move within it. Thesliders 452 may be shaped in any appropriate manner. As one example, aconnector deployer 452 is substantially curved at itsouter end 454 and substantially flat at itsinner end 456. Theconnector deployer 452 may vary in height along at least a portion of its length and/or width. As one example, aregistration element 458 may extend upward from theupper surface 460 of theconnector deployer 452. Theregistration element 458 may be formed into theconnector deployer 452, or otherwise manufactured into it or connected to it. - Where a
registration element 458 is used, the correspondingconnector bay 448 is shaped accordingly. That is, the size, shape and orientation of theregistration element 458 of theconnector deployer 452 corresponds to the size, shape and orientation of aregistration feature 462 of theconnector bay 448. For example, where theconnector deployer 452 andregistration element 458 ofFIG. 65 is used, the correspondingconnector bay 448 is shaped as shown inFIG. 66 . Theregistration element 458 translates along theregistration feature 462 as theconnector deployer 452 translates along theconnector bay 448. In this way, theconnector deployer 452 is maintained in a desired orientation throughout its translation relative to theconnector bay 448, and theconnector deployer 452 is prevented from cocking in theconnector bay 448 during that translation. Thesliders 452 andcorresponding connector bays 448 may be shaped differently, if desired. Thesliders 452 are all shaped substantially identically. Alternately, at least one of thesliders 452 is shaped differently from at least one of the others, and the corresponding connector bay orbays 448 are shaped accordingly. Optionally, a biocompatible lubricant such as sodium stearate may be used between at least oneconnector deployer 452 and the correspondingconnector bay 448 to facilitate the translation of theconnector deployer 452 relative to theconnector bay 448. - Each
connector deployer 452 is moveable between a first position and a second position. In the first position, theouter end 454 of theconnector deployer 452 extends at least partially into thepassage 440. Alternately, the outer end of theconnector deployer 452 does not extend into thepassage 440. In the second position, theconnector deployer 452 has translated relative to the correspondingconnector bay 448 and completed its motion. Theouter end 454 of theconnector deployer 452 no longer extends into thepassage 440. Alternately, theouter end 454 of theconnector deployer 452 still extends into thepassage 440 in the second position. Eachconnector deployer 452 translates or otherwise moves from the first position to the second position as a result of contact with theramp element 446. This translation is described in greater detail below. - A
connector 464 is placed in at least oneconnector bay 448. In an exemplary embodiment shown inFIG. 64 , theconnector 464 is a staple. Eachconnector 464 is located closer to theinner surface 450 of thearm 402 than the correspondingconnector deployer 452. Theconnector 464 may be configured as disclosed in pending U.S. patent application Ser. No. 10/309,519 filed on Dec. 4, 2002, which is hereby incorporated by reference in its entirety. As one example, referring also toFIG. 67 , theconnector 464 includes fourtines 466 extending from abase 468. Thetines 466 may be offset from one another. A different configuration ofconnector 464 may be used, if desired. Theconnector 464 is constructed from 316L stainless steel, but may be constructed from a different type of stainless steel, or from a different material. As another example, theconnector 464 may be a connector other than a staple, such as a pin or clip. - Each
connector 464 is oriented in theconnector bay 448 such that thetines 466 extend in a direction facing substantially out of theconnector bay 448. Alternately, eachconnector 464 is oriented differently. Thebase 468 of theconnector 464 may be in contact with the inner end of the correspondingconnector deployer 452 when thatconnector deployer 452 is in the first position, or may be spaced apart from the inner end of thatconnector deployer 452 in the first position. When theconnector deployer 452 is in the first position, the correspondingconnector 464 is held within theconnector bay 448 in any appropriate way. Referring also toFIG. 66 , as one example, thetines 466 of eachconnector 464 may be biased against at least part of the correspondingconnector bay 448. For example, at least onetine 468 may be biased against alower surface 470 of theconnector bay 448 and at least one other tine 469 may be biased against anupper surface 472 of theconnector bay 448. The biasing force exerted by eachtine 468 against thecorresponding surface connector bay 448 holds theconnector 464 in place when theconnector deployer 452 is in the first position. The biasing forces exerted by thetines 468 are high enough to hold theconnector 464 securely within theconnector bay 448, and are low enough to allow theconnector 464 to translate easily as a result of contact with the correspondingconnector deployer 452. As another example, eachconnector 464 may be held in place in the correspondingconnector bay 448 with a biocompatible substance that provides friction between thatconnector 464 and theconnector bay 448, where the amount of force required to overcome that friction and move theconnector 464 is selected to be less than the amount of deployment force to be exerted on theconnector 464 by the correspondingconnector deployer 452. The translation of aconnector deployer 452 from the first position to the second position causes deployment of thecorresponding connector 464, as described in greater detail below. - The
ramp element 446 translates or otherwise moves within thepassage 440, as described above. Thedistal end 474 of theramp element 446 is configured to engage thesliders 452 as it moves, causing thosesliders 452 in turn to translate or otherwise move relative to theirrespective connector bays 448. As one example, theramp element 446 is curved and/or angled at itsdistal end 474, where the curvature and/or angularity begins at or near the most distal point of theramp element 446 and continues proximally along theinner surface 476 of theramp element 446. That is, theramp element 446 increases in width from its most distal point to a selected point spaced apart from and proximal to that most distal point. Theramp element 446 may be shaped such that the curvature and/or angularity of thedistal end 474 is present on theinner surface 476 of theramp element 446, and such that theouter surface 478 of theramp element 446 is substantially flat against a wall of thepassage 440. However, theramp element 446 may be shaped in any other appropriate manner. Theramp element 446 may be translated distally along at least a portion of thepassage 440. In the course of this translation, thedistal end 474 of theramp element 446 sequentially contacts and thereby actuates thesliders 452, beginning with the most proximal and concluding with the most distal. Alternately, theramp element 446 translates proximally to contact and actuate sequentially thesliders 452, beginning with the most distal and concluding with the most proximal. Alternately, theramp element 446 is configured to move in such a manner that at least a component of its motion is toward theinner surface 450 of thearm 402, such that theramp element 446 engages more than oneconnector deployer 452 at a time. Thus, theramp element 446, another component of thesled 482, or a different component may actuate thesliders 452 serially or in parallel. - Optionally, one or more of the
sliders 452 are omitted from thetissue effector 400, such that theramp element 446 and/or a different component of thesled 482 directly contacts one or more of thestaples 464 to urge that staple orstaples 464 out of thecorresponding arm 402. That is, the intermediate mechanism between thesled 482 and at least one of thestaples 464 may be omitted. If so, thesled 482 and/or at least oneconnector 464 are configured such that contact between them urges theconnector 464 in the desired direction. For example, one or more of thestaples 464 may include a structure analogous to theconnector deployer 452 formed into it, where that structure is implanted into the patient along with theconnector 464. This additional structure is small, and is positioned outside the lumen of both the graft vessel and the target vessel, such that its presence in the patient has no effect. Such a structure may be composed of stainless steel or other biocompatible material, or from bioabsorbable material that is gradually absorbed by the patient. Such biocompatible and bioabsorbable materials are standard in the art. - Optionally, one or more of the
connector bays 448 may be omitted from one or more of thearms 402 of thetissue effector 400. For example, if thestaples 464 are deployed in parallel, thestaples 464 may be connected to thesled 482 or other component such as by adhesive, where that connection is able to withstand an amount of force less than the force with which the deployedconnector 464 grips thegraft vessel 404 and thetarget vessel 580. As a result, after thestaples 464 are deployed into tissue and grip thevessels sled 482 or other component is pulled away from the anastomosis, the connection between eachconnector 464 and thesled 482 or other component is broken, thereby freeing thestaples 464 from thetissue effector 400. - Referring also to
FIGS. 58 and 74 , theanvil 10 is connected to a force transmission mechanism such as afirst cable 480. As described above, theanvil 10 may include acutter stop 236 having one or more attachment features 270 to which thefirst cable 480 is connected. However, thefirst cable 480 may be connected to a different or an additional part of theanvil 10. - The
sled 482 is connected to a force transmission mechanism such as asecond cable 490. As described above, thesled 482 includes anattachment feature 488 to which thesecond cable 490 is connected. However, thesecond cable 490 may be connected to a different or an additional part of thesled 482. Alternately, one or both of thecables - The
cables tissue effector 400. Optionally, acable housing 306 is provided. Thecable housing 306 is a tube that is at least partially flexible, through which at least a portion of thecables cable housing 306, such that eachcable FIG. 57 , thestaple holder 38 includes acollar 492. Thecollar 492 may be formed into thestaple holder 38, or formed separately from and attached to thestaple holder 38. Thecollar 492 includes apassage 494 therethrough. The diameter of thepassage 494 may be substantially the same as the outer diameter of thecable housing 306, such that the distal end of thecable housing 306 may be received into and/or through thecollar 492 and held therein. Similarly, the shape of thepassage 494 may substantially correspond to the shape of the distal end of thecable housing 306. The distal end of thecable housing 306 is fixed to thecollar 492 via a friction fit, adhesive, welding, or any other appropriate structure, mechanism or method. Thecable housing 306 need not have a uniform shape, size or cross-section along its entire length. Alternately, the distal end of thecable housing 306 may connect to a different portion of thetissue effector 400, or may not connect to thetissue effector 400 at all. Additionally, thecable housing 306 may pass over and/or connect to one or more of theconnection members 280 of thetissue effector 400, and/or one or more other components of thetissue effector 400. - One or
more channels 496 may be defined on the surface of thestaple holder 38 distal to thecollar 492. Eachchannel 496 receives acable channel 496 may be curved in a convex manner, such that thecorresponding cable channel 496 to be located between the upper and lower ends of thechannel 496. Thecable channel 496 may be under tension, such that it follows the curvature of thatchannel 496. Thus, thechannel 496 causes thecable second cable 490 is connected to thesled 482. Tension on thesecond cable 490 that results from proximal motion of its proximal end also results in distal motion of thesled 482. - Referring also to
FIG. 56 , theshaft 304 may be bifurcated at its distal end, forming two spaced-apartarms 305. Thecable housing 306 passes between thearms 305, such that thearms 305 constrain the potential lateral motion of thecable housing 306. Alternately, thecable housing 306 does not pass between thearms 305. At least onearm 305 forms or connects to apaddle 307 at its distal end. Thecable housing 306 extends in a curved configuration, such as an S-shaped or serpentine configuration, between theshaft 304 and thetissue effector 400. The paddle or paddles 307 may be substantially planar and parallel to one another. A receivingopening 309 is provided through at least onepaddle 307, each opening corresponding to acog 282 of thetissue effector 400. One ormore detents 310 are present along the perimeter of the receivingopening 309, corresponding to theteeth 284 of thecog 282. Theteeth 284 are configured to engage thedetents 310 in the receivingopening 309. Thebutton 278 connected to thecog 282 may be connected to the spine 272 with asingle connection member 280 spaced apart from thecog 282, or may be connected to the spine 272 with one or moreflexible connection members 280. As a result, thebuttons 278 can be compressed together, such that theteeth 284 are moved out of engagement with thecorresponding detents 310. Thecog 282 thus can be moved to a position out of contact with the receivingopening 309, such that it is located between thepaddles 307. Consequently, thecog 282 and thetissue effector 400 can be freely rotated to a desired orientation. Thebuttons 278 are then released, such that thecog 282 re-enters the receivingopening 309 and theteeth 284 engage thedetents 310 in the receivingopening 309 once again. Alternately, thecog 282 engages a corresponding gear or other structure or mechanism in or on theshaft 304, such that motion of the corresponding gear rotates thecog 282. Alternately, thecog 282 is connected to theshaft 304 or one or more components in and/or on theshaft 304 in such a way that thecog 282 can be rotated or otherwise manipulated as desired. Alternately, thetissue effector 38 is connected to theshaft 304 with a mechanism or structure other than or in addition to thecog 282. - The
cog 282 allows thetissue effector 38 to be oriented at a plurality of positions relative to theshaft 304. That is, thecog 282 allows thetissue effector 38 to move such that the longitudinal centerline of thetissue effector 38 may be positioned at more than one angle relative to the longitudinal centerline of theshaft 304. Thecog 282 or other mechanism may allow thetissue effector 38 to move smoothly through a range of orientations relative to thehandle 302, or may allow thetissue effector 38 to move among two or more discrete orientations relative to thehandle 302. Thus, thetissue effector 38 is orientable to two or more different positions relative to thehandle 302. The relative motion between thetissue effector 38 and theshaft 304 allows thetissue effector 38 to be utilized on target vessels having a number of different orientations within the patient, while allowing convenient access by the surgeon or other medical professional. That is, the surgeon may hold thehandle 302 in a single convenient position, and orient thetissue effector 38 into a selected position relative to theshaft 304 and handle 302 that is optimal for use with a particular target vessel. Optionally, thearms 305 or a mechanism connected to the arms may be capable of rotation relative to theshaft 304, providing additional freedom of motion for thetissue effector 38. Alternately, thecog 282 is not present, and thearms 305 otherwise allow motion of thetissue effector 38 relative to theshaft 304. Alternately, thetissue effector 400 is fixed relative to theshaft 304. - Referring also to
FIG. 55 , theshaft 304 is substantially hollow along at least part of its length, starting at its proximal end and continuing distally. Theentire shaft 304 may be substantially hollow. Anaperture 498 or other opening is located in the wall of theshaft 304 at a point along its length where it is hollow. Thus, theaperture 498 provides access to the lumen of theshaft 304. Thecable housing 306 extends through theaperture 498 into the lumen of theshaft 304. Alternately, thecable housing 306 does not enter the lumen of theshaft 304, and instead is attached to the outer surface of theshaft 304 with adhesive, clips, pins, and/or any other appropriate attachment mechanisms, structures or methods. If so, theshaft 304 need not include a lumen. Alternately, thecable housing 306 does not connect to theshaft 304 at all, and instead connects to thehandle 302 directly. If so, theshaft 304 need not include a lumen, and may be solid. - The proximal end of the
shaft 304 is connected to thehandle 302. Thehandle 302 may be formed from two or more individualhandle shell members 502 that are connected to one another. Alternately, thehandle 302 may be constructed differently. Theshaft 304 may be fixed to thehandle 302 such that it does not substantially move relative to thehandle 302. Referring also toFIG. 70 , as one example, amember 500 extends from onehandle shell member 502 into the hollow interior of thehandle 302. Thatmember 500 may connect at its other end to the otherhandle shell member 502. The proximal end of theshaft 304 includes acorresponding aperture 504, such that themember 500 fits within theaperture 504. Theaperture 504 is substantially the same size as the cross-section of themember 500. When theshell members 502 are assembled, themember 500 engages theaperture 504 of theshaft 304 and holds theshaft 304 in place. Alternately, amember 500 extends from eachhandle shell member 502, and thosemembers 500 both engage theaperture 504 of theshaft 304. As another example, ribs (not shown) may be defined in the inner surface of the handle, and a corresponding retainer (not shown) is defined at or near the proximal end of the shaft. The retainer is wider than theshaft 304, and has a selected thickness. The ribs are spaced apart from one another substantially the same distance as the thickness of the retainer. The ribs thus substantially prevent theshaft 304 from translating proximally or distally. Thehandle 302 may engage the retainer with a registration feature or other structure or mechanism to substantially prevent rotation of theshaft 304 about its longitudinal axis. Alternately, thehandle 302 holds theshaft 304 in a different way. - The
handle 302 has a substantially hollow interior. Where theshaft 304 includes a lumen, the lumen of theshaft 304 opens into the interior of thehandle 302. Thecables shaft 304 into the hollow interior of thehandle 302. Alternately, thecables cable housing 306 directly into thehandle 302, bypassing theshaft 304. - Referring to
FIG. 70 , mechanisms within thehandle 302 are utilized to actuate thetissue effector 38 via thecables handle 302. A single input to theanastomosis tool 300 via thetrigger 308 actuates theanastomosis tool 300. Alternately, one or more additional inputs to theanastomosis tool 300 are required, such as actuation of a safety switch or depression of a second feature. Thetrigger 308 initially extends outward from the upper surface of thehandle 302 through anaperture 506 in thehandle 302. Alternately, thetrigger 308 initially extends from a different surface of thehandle 302. Alternately, thetrigger 308 is initially flush with the surface of thehandle 302, or otherwise configured. Thehandle 302 may be shaped ergonomically for ease of operation. For example, as shown inFIG. 70 , thehandle 302 is curved and tapered slightly toward its proximal end, and substantially bilaterally symmetrical, such that the proximal end of thehandle 302 can be gripped easily with either the left or the right hand. Alternately, thehandle 302 may be ergonomically configured in a different way for ease of actuation by the user. Thetrigger 308 is positioned on thehandle 302 such that it can be actuated conveniently by a user's thumb. Alternately, thetrigger 308 could be placed on the underside of thehandle 302 for actuation with the index finger of either hand. More than one finger may be used to actuate thetrigger 308 and/or other mechanisms for actuating theanastomosis tool 300. - The
trigger 308 is connected to arocker 508. Thetrigger 308 may be formed into therocker 508, or otherwise connected to it. Therocker 508 is located inside thehandle 302. Alternately, therocker 508 is located at least partly outside thehandle 302. Therocker 508 is rotatably mounted to arocker axle 510. Therocker axle 510 extends from one interior surface of thehandle 302, and may extend to a different interior surface of thehandle 302 to provide additional stiffness and/or stability to therocker axle 510. Alternately, therocker axle 510 may connect to thehandle 302 in a different way. - The
rocker 508 includes aproximal arm 514 extending proximally to therocker axle 510. Theproximal arm 514 may be formed into therocker 508, or otherwise connected to it. Theproximal end 516 of theproximal arm 514 may be tapered to a curved or rounded surface. Alternately, theproximal end 516 of theproximal arm 514 is shaped differently. Alternately, the entireproximal arm 514 is tapered. Therocker axle 510 is located proximal to thetrigger 308. As a result, depression of thetrigger 308 causes rotation of therocker 508 such that theproximal end 516 of theproximal arm 514 moves upward. Alternately, thetrigger 308 and therocker axle 510 are positioned differently relative to one another. Therocker 508 also includes adistal arm 518 extending distal to thetrigger 308, where thedistal arm 518 has adistal end 520. Thedistal arm 518 may be formed into therocker 508, or otherwise connected to it. Referring also toFIG. 71 , at least a portion of thedistal arm 518 may be bifurcated into two or more spaced-apartmembers 542. Apost 544 may be located at the distal end of eachmember 542. At least onepost 544 substantially may take the shape of a cylindrical or rectangular solid. Eachpost 544 is angled relative to the correspondingmember 542, protruding at least partly inward. This angle may be substantially ninety degrees, or any other angle. Alternately, at least onepost 544 extends outward from the corresponding member. Theposts 544 are spaced apart from one another by a distance that is less than the distance separating the spaced-apartmembers 542. Alternately, at least onepost 544 is located at a position on the correspondingmember 542 other than its distal end. As one example, at least onepost 544 may be positioned a short distance proximal to the distal end of the correspondingmember 542. - Because the
rocker axle 510 is located proximal to thetrigger 308, depression of thetrigger 308 causes thedistal end 520 of thedistal arm 518 to move downward. Alternately, thearms rocker 508 are configured to move in another manner when thetrigger 308 is depressed. Alternately, therocker 508 may be shaped or configured differently than described above. - A
proximal slider 522 is also included within thehandle 302. Theproximal slider 522 includes at least oneflange 524 extending laterally from at least one side thereof. Advantageously, aflange 524 extends from each side of theproximal slider 522 for stability.Additional flanges 524 may be provided, if desired.Ribs 526 are molded, formed, connected or otherwise attached to the inner surface of thehandle 302. Tworibs 526 are spaced apart from one another a distance substantially equal to the thickness of thecorresponding flange 524, such that eachflange 524 is configured to slide therebetween. Each pair ofribs 526 substantially constrains the motion of thecorresponding flange 524. Where theribs 526 are substantially linear, andribs 526 andcorresponding flanges 524 are utilized on opposite sides of theproximal slider 522, theribs 526 substantially linearly constrain the motion of thecorresponding flange 524. Aspring 546 is connected at one end to thehandle 302, and is connected to or engages theproximal slider 522. Thespring 546 is in compression, and thereby biases theproximal slider 522 distally. Astop 547 may be connected to or defined in the inner surface of one or more of thehandle shell members 502, where the stop or stops 547 are located distal to theproximal slider 522. The stop or stops 547 act to restrain the distal motion of theproximal slider 522, thereby defining a position that is the most distal theproximal slider 522 can travel. Alternately, a different or additional mechanism, structure or method may be used to bias theproximal slider 522 distally. Alternately, thespring 546 is initially neither in tension nor compression, but is compressed by therocker 508 during at least a portion of its travel. - The
spring 546 stores energy within itself when it is in tension. Alternately, an energy storage device could be used in lieu of thespring 546. As one example, the energy storage device is a reservoir or cylinder of pressurized gas. Valves, tubing and/or other structure may be used to route the pressurized gas to desired locations in thehandle 302 such that the energy stored in the gas is used to bias theproximal slider 522 distally, and/or to perform other actuation functions within thehandle 302 and/or thetool 300. The gas may be carbon dioxide, nitrogen, a different gas, air, or a combination of gases. As another example, a cylinder or source of vacuum may be used as an energy storage device. Valves, tubing and/or other structure may be used to route the vacuum to desired locations in thehandle 302 such that the vacuum can be used to bias theproximal slider 522 distally, and/or to perform other actuation functions within thehandle 302 and/or thetool 300. That is, compressed gas may be used for controlling the operation of thetool 300 instead of or in addition to providing energy storage. As another example, a battery may be used as an energy storage device. Wiring and actuators such as solenoids or motors may be provided within thehandle 302 such that the stored electrical energy in the battery is used to bias or hold theproximal slider 522 distally, and/or to perform other actuation functions within thehandle 302 and/or thetool 300. That is, electromagnetic energy may be used for controlling the operation of thetool 300 instead of or in addition to providing energy storage. Where such an alternate energy storage device is provided, thetrigger 308 may be configured differently, such that actuation of theanastomosis tool 300 may be performed simply by contacting thetrigger 308 with a finger, or moving thetrigger 308 through a more limited range of motion. Alternately, thetrigger 308 may be omitted altogether, and theanastomosis tool 300 may be actuated remotely by a computer, dedicated control station, handheld computing device, or other device. - A
contact feature 528 is defined on the distal surface of theproximal slider 522. Alternately, thecontact feature 528 is a separate element connected to theproximal slider 522. Thecontact feature 528 is configured to engage theproximal end 516 of theproximal arm 514 at or after the time thetrigger 308 is depressed, as described in greater detail below. Thecontact feature 528 is angled proximally and downward along alower portion 530 thereof, and is substantially vertical along anupper portion 532 thereof. Alternately, thecontact feature 528 is shaped and/or angled differently. - The first cable or
cables 480 are connected to theproximal slider 522 in any appropriate way. As an example, at least one aperture or port (not shown) may be formed in theproximal slider 522, and at least onecable 480 is inserted into at least one aperture and secured thereto. As other examples, an end of the cable orcables 480 may be wound around all of or a portion of, crimped to, welded to, or secured by adhesive to theproximal slider 522. Theproximal arm 514 of therocker 508 may be bifurcated to allow the first cable orcables 480 to extend substantially along the longitudinal centerline of thehandle 302 and between the bifurcations substantially without interference. Similarly, thelower portion 530 of thecontact feature 528 may be bifurcated as well. Where both theproximal arm 514 and thecontact feature 528 are bifurcated, the two are aligned such that they contact one another during at least a portion of the travel of therocker 508. - A
distal slider 534 is also included within thehandle 302. Thedistal slider 534 includes aflange 536 extending outward from at least one side thereof. Advantageously, aflange 536 extends from each side of thedistal slider 534 for stability.Additional flanges 536 may be provided, if desired.Ribs 538 are molded, formed, connected or otherwise attached to the inner surface of thehandle 302. Tworibs 538 are spaced apart from one another a distance substantially equal to the thickness of thecorresponding flange 536, such that eachflange 536 is configured to slide therebetween. Each pair ofribs 538 substantially constrains the motion of thecorresponding flange 536. Where theribs 538 are substantially linear, andribs 538 andcorresponding flanges 536 are utilized on opposite sides of thedistal slider 534, theribs 538 substantially linearly constrain the motion of thecorresponding flange 524. - A contact surface 548 is defined on at least a portion of the proximal surface of the
distal slider 534. The contact surface 548 may be curved or angled. As one example, the contact surface 548 has a concave curvature. Other shapes or configurations of the contact surface 548 may be utilized. Alternately, the contact surface 548 is located on a portion of thedistal slider 534 other than its proximal surface. Thedistal slider 534 may include apassage 550 through it to allow thecables passage 550 is not provided in thedistal slider 534, and thedistal slider 534 is bifurcated or otherwise shaped to allow thecables cables distal slider 534 altogether. - The
distal slider 534 may include alower guide 552. Thelower guide 552 extends downward from the remainder of thedistal slider 534, and may extend proximal to the contact surface 548. Further, thelower guide 552 may be thinner than the remainder of thedistal slider 534. Alternately, thelower guide 552 is not included in thedistal slider 534, or may be configured differently relative to the remainder of thedistal slider 534. Optionally, thelower guide 552 may include aflange 554 extending outward from at least one side thereof. Advantageously, aflange 554 extends from each side of thelower guide 552 for stability.Additional flanges 554 may be provided, if desired. Theseflanges 554 provide additional stability to thedistal slider 534.Ribs 556 are molded, formed, connected or otherwise attached to the inner surface of thehandle 302. Tworibs 556 are spaced apart from one another a distance substantially equal to the thickness of thecorresponding flange 554, such that eachflange 554 is configured to slide therebetween. Each pair ofribs 556 substantially constrains the motion of thecorresponding flange 554. Where theribs 556 are substantially linear, andribs 556 andcorresponding flanges 554 are utilized on opposite sides of thedistal slider 534, theribs 556 substantially linearly constrain the motion of thecorresponding flange 554. - A
spring 540 is connected at one end to thedistal slider 534 and at the other end to thehandle 302. Anaperture 558 may be provided in thelower guide 552, or in another part of thedistal slider 534. One end of thespring 540 includes a hook or similar structure, which is received into and held by theaperture 558. Alternately, thespring 540 is connected to thedistal slider 534 in a different way. Thespring 540 is in tension, and thereby biases thedistal slider 534 proximally. Alternately, a different or additional mechanism, structure or method may be used to bias thedistal slider 534 proximally. - A
holder 594 is connected to the inner surface of thehandle 302. This connection may be accomplished in any appropriate manner. As one example, a slot 602 may be defined in a member 604 or between two separate members 604 extending inward from the inner surface of eachshell member 502, wherein a portion of theholder 594 is held by the slot 602 such as by a pressure fit. The distal end 595 of theholder 594 is held by the slot 602 such that it does not substantially move. Alternately, a different part of theholder 594 is held by the slot 602, and/or the distal end 595 of theholder 594 is free to move. Moving proximally from the distal end 595 of theholder 594, theholder 594 is bifurcated by an opening 598 that extends substantially longitudinally. Two spaced-apart members 600 extend substantially proximally, each member 600 on an opposite side of the opening 598. At least the members 600 of theholder 594 have some flexibility, such that the members 600 can move up or down in response to force applied to them. However, the members 600 are stiff enough to remain in a neutral position until that force is applied. - A stop 596 extends upward from each member 600. The stops 596 are positioned and shaped to engage the
bottom edge 570 of the contact surface 548 of thedistal slider 534. Theholder 594 is substantially restrained against longitudinal motion by its engagement with the slots 602 in theshell members 502 ad/or members 604 defined in or on theshell members 502. Thus, by engaging thebottom edge 570 of the contact surface 548 of thedistal slider 534, the stops 596 substantially restrain thedistal slider 534 against proximal motion under the influence of thespring 540. The stops 596 are stiff enough, and extend upward enough, to provide this restraint. For example, the stops 596 may be curved to match the curvature of the contact surface 548, such that they contact a portion of the contact surface. Alternately, contact between thedistal slider 534 and therocker 508 prevents thedistal slider 534 from substantially moving proximally. This contact occurs between the contact surface 548 of thedistal slider 534 and thedistal tip 520 of thedistal arm 518 of therocker 508. Alternately, this contact occurs between other or additional components of thedistal slider 534 and/or therocker 508. - The
spring 540 stores energy within itself when it is in tension. Alternately, an energy storage device such as a reservoir or container of pressurized gas, a battery, or other energy storage device could be used in lieu of thespring 540. Where a reservoir of pressurized gas is utilized, valves, tubing and other structure may be used to route the pressurized gas to desired locations in thehandle 302 such that the energy stored in the gas is used to bias thedistal slider 534 proximally, and/or to perform other actuation functions within thehandle 302 and/or thetool 300. Similarly, where a battery is utilized, wiring and actuators such as solenoids or motors may be provided within thehandle 302 such that the stored electrical energy in the battery is used to bias or hold thedistal slider 534 proximally, and/or to perform other actuation functions within thehandle 302 and/or thetool 300. Where such an alternate energy storage device is provided, thetrigger 308 may be configured differently, such that actuation of theanastomosis tool 300 may be performed simply by contacting thetrigger 308 with a finger, or moving thetrigger 308 through a more limited range of motion. Alternately, thetrigger 308 may be omitted altogether, and theanastomosis tool 300 may be actuated remotely by a computer, dedicated control station, handheld computing device, or other device. - The
second cable 490 is connected to thedistal slider 534 in any appropriate way. As an example, at least one aperture or port (not shown) may be formed in thedistal slider 534, and at least onecable 480 is inserted into at least one aperture and secured thereto. As other examples, an end of the cable orcables 480 may be wound around all of or a portion of, crimped to, welded to, or secured by adhesive to thedistal slider 534. Thesecond cable 490 may have an amount of slack in it when thedistal slider 534 is in the first, predeployment position shown inFIG. 70 . The amount of slack, if any, is related to the distance traveled by thedistal slider 534 during actuation, as described in greater detail below. - Optionally, the
distal slider 534 includes averification stub 560. Theverification stub 560 extends substantially upward from the upper end of thedistal slider 534. Alternately, theverification stub 560 extends from a different portion of thedistal slider 534, or in a different direction. Theverification stub 560 may extend into or through aslot 562 through thehandle 302. Because it is connected to thedistal slider 534, theverification stub 560 moves along theslot 562 in thehandle 302 when thedistal slider 534 moves during operation, as described below. As a result, the position of theverification stub 560 may be used to confirm visually whether aparticular anastomosis tool 300 has been actuated or not. That is, theverification stub 560 may be located in a first position before theanastomosis tool 300 is actuated, and in a second position after theanastomosis tool 300 is actuated, such that the user can determine whether theanastomosis tool 300 has been actuated by viewing the position of theverification stub 560. - Optionally, the
rocker 508 includes aratchet 564 extending substantially downward from a location distal to therocker axle 510. Alternately, theratchet 564 extends in a different direction. Theratchet 564 includes amember 566 at its lower end extending substantially transverse to the remainder of theratchet 564. Alternately, themember 566 extends in a different direction. Alternately, themember 566 is a notch or other element defined in theratchet 564. Theratchet 564 moves in conjunction with therocker 508. Thus, when thetrigger 308 is depressed and the distal end of therocker 508 moves downward, theratchet 564 moves downward as well. Apawl feature 568 is configured to engage themember 566 of theratchet 564 after theratchet 564 has moved downward a particular distance, allowing theratchet 564 to continue to move downward after engagement, but preventing theratchet 564 from moving back upward past thepawl feature 568 after engagement. - Alternately, the
rocker 508,sliders tissue effector 400 and complete the anastomosis. For example, a fluid logic mechanism may be used, where a container of gas within the handle or a connection to a tank outside the handle provides gas under pressure to a switching assembly or other mechanism. The switching assembly utilizes and/or directs the pressure of the gas to successively actuate the components of thetissue effector 400. Vacuum or liquid may be used instead of gas, if desired. As another example, thehandle 302 may include an electromechanical assembly under analog or digital control, such that actuation of thetrigger 308 or other component causes actuation of the tissue effector. - The operation of the
anastomosis tool 300 will now be described. Referring toFIGS. 59 and 74 , an end of thegraft vessel 404 is incised substantially in the longitudinal direction to formflaps 404 therein. At least one incision may be made in a different direction. Advantageously, two incisions are made to create twoflaps 404 of substantially the same size. However, theflaps 404 may be of different sizes. Further, more than twoflaps 404 may be created with more than two incisions. Alternately, asingle flap 404 is made with a single incision. Thegraft vessel 404 is loaded onto thestaple holder 38 as described above, such that eachflap 408 is held between agraft clip 412 in the closed position and aflap receiving surface 406, and thegraft vessel 404 extends between thearms 402 of thestaple holder 38. Referring also toFIG. 70 , theanastomosis tool 300 is initially in a pre-deployment configuration. In this configuration, thedistal arm 518 of therocker 508 is at an uppermost position, thetrigger 308 correspondingly extends outward from thehandle 302 to its greatest extent, and theproximal arm 514 of therocker 508 is at a lowermost position. Thedistal end 520 of thedistal arm 518 of therocker 508 may engage the contact surface 548 of thedistal slider 534 at or near the uppermost end of the contact surface 548. This contact may be between theposts 544 of thedistal arm 518 and the contact surface 548, and/or between another portion of thedistal arm 518 and the contact surface 548. The stops 596 of theholder 594 hold thedistal slider 534 substantially in place against the proximal bias exerted by thespring 540. Alternately, where theholder 594 is not used, contact between the rigiddistal arm 518 and the contact surface 548 holds thedistal slider 534 substantially in place against the proximal bias exerted by thespring 540. In the pre-deployment configuration, theproximal end 516 of theproximal arm 514 may be spaced apart from thelower portion 530 of theproximal slider 522, or may be in contact with thelower portion 530 of theproximal slider 522. Theproximal slider 522 is biased distally to its most distal possible position. Alternately, theproximal slider 522 is positioned differently in the pre-deployment configuration. Alternately, therocker 508 and/or thetrigger 308 may be in a different position in the pre-deployment configuration, particularly where therocker 508 and/or trigger 308 are shaped or configured differently than shown inFIG. 70 . If so, therocker 508 may engage theproximal slider 522 and/or thedistal slider 534 in a different manner than described above. - Referring also to
FIG. 77 , when thehandle 302 is in the pre-deployment configuration, the time is t=0. Theposition 590 of theproximal slider 522 is at an initial position, and theposition 592 of thedistal slider 534 is also at an initial position. Thepositions sliders FIG. 77 are qualitative, and are shown with respect to an arbitrary point selected between them. That is, the graph ofFIG. 77 illustrates an exemplary set of motions of thesliders - The first cable or
cables 480 are connected to theproximal slider 522 and thesecond cable 490 is connected to thedistal slider 534, as described above. In the pre-deployment configuration, bothcables trigger 308 takes up the slack and causes thecables trigger 308 before deployment is intended do not begin the actuation of theanastomosis tool 300. Alternately, one or more of thecables - The
second cable 490 is also connected to thesled 482 in thetissue effector 400, as described above. Referring also to FIGS. 64 and 68-69, in the pre-deployment configuration thesled 482 is positioned such that eachramp element 446 is located within thecorresponding passage 440 in thecorresponding arm 402, proximal to theconnector bays 448. Similarly, in the pre-deployment configuration thesled 482 is positioned such that eachvein knife 432 is located proximal to thevein flap 408 held between thegraft clip 412 and the correspondingflap receiving surface 406. Alternately, thesled 482 is positioned differently in the pre-deployment configuration. For example, eachramp element 446 may be positioned initially in a location distal to theconnector bays 448. Referring also toFIG. 72 , eachflap 408 is held between agraft clip 412 and aflap receiving surface 406 as described above, such that thegraft vessel 404 extends between thearms 402 of thetissue effector 400. Theflaps 408 are held on the undersides of thearms 402. Eachflap 408 is held by the correspondinggraft clip 412 such that a portion of theflap 408 at itsroot 405, which is the portion of theflap 408 at or in proximity to its intersection with the tubular portion of thegraft vessel 404, is exposed. Theroot 405 of eachflap 408 is configured to contact the outer surface of the target vessel, as described in greater detail below. - Optionally, the orientation of the
tissue effector 400 may be changed relative to thehandle 302. Thus, thetissue effector 400 can be oriented relative to the target vessel such that theanvil arm 14 is aligned with it, and thehandle 302 can be placed in a convenient position for the user. To re-orient thetissue effector 400, the user depresses thebuttons 278, disengaging theteeth 284 of thecog 282 from thedetents 310 of the receivingopening 309. Thetissue effector 400 is then rotated to the desired orientation. Thebuttons 278 are then released, allowing theteeth 284 of thecog 282 to engage once again thedetents 310 of the receivingopening 309. Thecog 282 is thus held securely in place in its new orientation. - Referring to
FIGS. 34 and 74 , in the pre-deployment configuration, the distal end of theanvil arm 14 is spaced apart from thestaple holder 38. Referring also toFIG. 75 , theanvil arm 14 is inserted through the wall of thetarget vessel 580. Thetarget vessel 580 may be a coronary artery, if theanastomosis tool 300 is used in the course of a CABG procedure, or any other appropriate bodily vessel or structure. Advantageously, theanvil arm 14 has a cross-section small enough to allow it to enter thetarget vessel 580 easily and to result in minimal or no leakage from the target vessel after theanvil arm 14 is removed. The distal tip of theanvil arm 14 may be sharp such that theanvil arm 14 itself penetrates the wall of thetarget vessel 580, resulting in an opening in the wall of thetarget vessel 580 substantially the same size as the cross-section of theanvil arm 14. Alternately, a sharp retractable projection, such as but not limited to theblade 78 ofFIGS. 13-14 or theblade 84 ofFIGS. 15-16 , is provided at the distal end of theanvil arm 14. The retractable projection is extended to allow the distal end of theanvil arm 14 to penetrate the wall of thetarget vessel 580, then retracted into theanvil arm 14. The retractable projection may be a wire, a blade, a substantially conical member, a screw or a screw-tipped rod, or any other sharp structure or mechanism capable of penetrating the wall of thetarget vessel 580. Such a retractable projection alternately may be as described in U.S. patent application Ser. No. 10/134,081, which is herein incorporated by reference in its entirety. Alternately, a separate mechanism or structure is used to penetrate the wall of thetarget vessel 580, and theanvil arm 14 is later inserted through that penetration. Alternately, thecutter 200 includes a sharp point at its distal end, where that sharp point extends out of the distal end of theanvil arm 14 to puncture the wall of thetarget vessel 580. If so, thecutter 200 may be actuated in a direction the reverse of that described below. - Referring also to
FIGS. 36 and 75 , after insertion, the distal end of theanvil arm 14 enters the lumen of thetarget vessel 580. Theanvil arm 14 is advanced into thetarget vessel 580 until atissue stop 220 on theanvil arm 14 encounters the edge of the penetration in the wall of thetarget vessel 580. Thetissue stop 220 is substantially flat and/or blunt, and extends upward or in another direction relative to theanvil arm 14 to increase the height and/or width of theanvil arm 14. Thetissue stop 220 increases the cross-section of theanvil arm 14 such that theanvil arm 14 cannot easily move further into the penetration in the wall of thetarget vessel 580 after the tissue stop 220 encounters the outer wall of thetarget vessel 580. Because thetissue stop 220 is blunt, it does not penetrate the wall of thetarget vessel 580 or act to expand the size of the existing penetration. Thus, the distance between the distal end of theanvil arm 14 and the tissue stop 220 substantially determines how much of theanvil arm 14 is allowed into the lumen of thetarget vessel 580. - Optionally, the distal end of the
anvil arm 14 is stabilized after insertion into thetarget vessel 580. This stabilization may be performed by, for example, extending pins (not shown) from thestaple holder 38 to theanvil arm 14, where the pins act to hold the distal end of theanvil arm 14 substantially in place. The pins may be sized and shaped to fit into depressions, slots or other features on theanvil arm 14. In this way, potential deflection of the distal end of theanvil arm 14 may be further reduced without the need for increasing the stiffness of theanvil arm 14. After theconnectors 464 have been deployed, the pins are retracted or otherwise moved away from theanvil arm 14, freeing it. Different or additional mechanisms, structures or methods may be used to stabilize theanvil arm 14. Optionally, a different part of theanvil arm 14 is stabilized in addition to or instead of the distal end of theanvil arm 14. - Next, referring also to
FIGS. 44 and 70 , an operator depresses thetrigger 308 of theanastomosis tool 300. As a result, therocker 508 begins to rotate about therocker axle 510, such that thedistal arm 518 moves downward and theproximal arm 514 of therocker 508 moves upward. As thetrigger 308 is depressed, thedistal end 520 of thedistal arm 518 moves downward. The stops 596 of theholder 594 continue to hold thedistal slider 534 substantially in place against the proximal bias exerted by thespring 540. Thus, thedistal slider 534 does not substantially move as thetrigger 308 is initially depressed. The contact surface 548 of thedistal slider 534 is curved to substantially match the travel of thedistal end 520 of thedistal arm 518. That is, the radius of curvature of the contact surface 548 relative to therocker axle 510 is substantially the same as the path of motion of thedistal end 520 of thedistal arm 518 as therocker 508 rotates, and thus does not substantially interfere with the motion of thedistal arm 518. If theholder 594 is not used, thedistal end 520 of thedistal arm 518 holds thedistal slider 534 in substantially the same position as thedistal arm 518 moves relative to the contact surface 548, due to the match between the curvature of the contact surface 548 and the motion of thedistal end 520 of thedistal arm 518. Alternately, the contact surface 548 is configured differently. Further, thedistal slider 534 may be configured to move as thetrigger 308 is initially depressed, if desired. - The
proximal end 516 of theproximal arm 514 moves upward as thetrigger 308 is depressed, and contacts thelower portion 530 of thecontact feature 528 of theproximal slider 522 if it is not initially in contact with theproximal slider 522. As theproximal end 516 of theproximal arm 514 continues to move upward, it continues to engage thelower portion 530 of thecontact feature 528 of theproximal slider 522. Thelower portion 530 of thecontact feature 528 is shaped such that a component of force exerted by theproximal end 516 of theproximal arm 514 on thatlower surface 530 is converted into a substantially translational force acting on theproximal slider 522 to urge it proximally. As one example, thelower portion 530 of thecontact feature 528 is angled proximally and downward. Further, theribs 526 andcorresponding flanges 524 of theproximal slider 522 substantially linearly constrain the motion of the proximal slider. The angle of thelower surface 530 relative to the arcuate motion of theproximal end 516 of theproximal arm 514 results in the conversion of the substantially arcuate motion of theproximal end 516 of theproximal arm 514 to substantially linear motion of theproximal slider 522. - Thus, the upward motion of the
rocker 508 against thelower portion 530 of thecontact feature 528 of theproximal slider 522 urges theproximal slider 522 in the proximal direction, against the bias of thespring 546 connected to theproximal slider 522 and thehandle 302. Referring also toFIG. 77 , this is time t=1, theproximal slider 522 has moved proximally from time t=0, and thedistal slider 534 has remained in substantially the same position it occupied at time t=0. As theproximal slider 522 moves proximally, it takes up slack in the first cable orcables 480 connected thereto, if slack is present. The first cable orcables 480 are fixed to theanvil 10. Because theanvil 10 is in turn fixed relative to theshaft 304, the proximal motion of the first cable orcables 480 removes slack from, then tensions, the first cable orcables 480. The first cable orcables 480 pass through at least a portion of thecable housing 306. As described above, thecable housing 306 curves between theshaft 304 and thetissue effector 400. The tension in the first cable orcables 480 causes thecable housing 306 to move. That is, the tension in the first cable orcables 480 acts upon theflexible cable housing 306, causing its curvature to decrease. Although thecable housing 306 is at least partially flexible, thecable housing 306 possesses stiffness longitudinally. Thus, as the curvature of thecable housing 306 decreases, the distal end of thecable housing 306 moves distally. Referring also toFIG. 58 , thestaple holder 38 is biased away from theanvil 10 by a biasingelement 475, which tends to move thetissue effector 400 to an open position. The biasingelement 475 may be a coil spring, leaf spring, or any other structure or mechanism capable of applying a biasing force. When the tension in the first cable orcables 480 causes the distal end of thecable housing 306 to move distally, the distal end of thecable housing 306 exerts a force on theanvil 10 that overcomes the bias of the biasingelement 475, causing theanvil 10 to rotate about a pivot point such as thepin 226 to a standby position. In this way, theanvil arm 14 remains substantially stationary within thetarget vessel 580, while thestaple holder 38 rotates. Alternately, thestaple holder 38 andanvil 10 may be actuated to move between the position shown inFIG. 34 and the position shown inFIG. 44 by any structure, mechanism or method. - Alternately, a second cable housing (not shown) is provided. If so, the first cable or
cables 480 may extend through thecable housing 306 as described above, and the second cable orcables 490 may extend through the second cable housing. In this way, the forces exerted along the first cable orcables 480 andcable housing 306 are substantially isolated from the forces acting along the second cable orcables 490 and the second cable housing. - Referring also to
FIGS. 29-31 , 44 and 76, as thestaple holder 38 andanvil 10 move closer together, thestaple holder 38 holds aroot 405 of eachflap 408 against or in proximity to the outer surface of the target vessel. For clarity, the flaps and graft vessel are not shown inFIG. 44 . That is, theroots 405 of theflaps 408 are apposed to the outer wall of thetarget vessel 580. As a result, a portion of the intimal layer of thegraft vessel 404 at theroot 405 of eachflap 408 is placed against the outer wall of thetarget vessel 580. Theflaps 408 are held by thestaple holder 38 in a substantially fixed position relative to the surface of thetarget vessel 580, such that the end of thegraft vessel 404 is substantially immobile relative to the wall of thetarget vessel 580. Thus, the position of the end of thegraft vessel 404 relative to the wall of thetarget vessel 580 remains substantially unchanged throughout the duration of the anastomosis procedure. Further, after theanvil arm 14 has been inserted into the lumen of thetarget vessel 580, thecontact surface 206 of theanvil arm 14 is substantially in contact with the inner surface of the wall of thetarget vessel 580. The perimeter of the end of thegraft vessel 404 defines a closed area on the wall of the target vessel. The location of a connection made between the end of thegraft vessel 404 and the wall of the target vessel is substantially registered with an opening made within the closed area in the wall of the target vessel, regardless of the order in which the connection and the opening are made. Further, the position of the end of thegraft vessel 404 relative to the wall of thetarget vessel 580 substantially maintains position registration throughout the duration of the anastomosis procedure relative to the opening in the wall of the target vessel through which theanvil arm 14 is inserted. - As the
staple holder 38 andanvil 10 move together, theengagement member 216 engages thereceiver 218. As described above, thereceiver 218 is defined in thesled 482. However, thereceiver 218 may be a separate component from thesled 482. Further, if theoptional safety feature 210 is utilized, the relative motion of thestaple holder 38 and theanvil 10 causes thestaple holder 38 to contact thesafety feature 210 and urge it downward against its upward bias. Consequently, thetip 212 of thesafety feature 210 is moved downward out of engagement with thesafety recess 214 of thecutter 200. Alternately, another structure or mechanism is configured to engage thesafety feature 210 when thestaple holder 38 andanvil 10 are moved together, so as to urge thetip 212 out of thesafety recess 214. Thus, in the standby position, thecutter 200 is freed for translation along thechannel 246. - Optionally, an
interface structure 238 may be connected to or formed into thestaple holder 38. Theinterface structure 238 engages theanvil 10 or a component associated with theanvil 10 as thestaple holder 38 and theanvil 10 move to the standby position, such as by snapping onto a corresponding feature (not shown) on theanvil 10. By doing so, theinterface structure 238 holds thestaple holder 38 substantially fixed relative to theanvil 10, in order to maintain registration between the target vessel, the graft vessel, theanvil 10 and thestaple holder 38. Theinterface structure 238 may be a tab, rail, bump, or any other feature that is capable of engaging a corresponding feature and holding thestaple holder 38 substantially fixed relative to theanvil 10. Alternately, theinterface structure 238 is formed into or connected to theanvil 10 and engages a corresponding feature on thestaple holder 38. - Referring also to
FIG. 70 , the user continues to depress thetrigger 308. As a result, therocker 508 continues to rotate about therocker axle 510 such that thedistal end 520 of thedistal arm 518 continues to move downward, and theproximal end 516 of theproximal arm 514 continues to move upward. As theproximal end 516 of theproximal arm 514 continues to move upward, its contact with thelower portion 530 of thecontact feature 528 of theproximal slider 522 continues to urge theproximal slider 522 proximally. When theproximal end 516 of theproximal arm 514 has reached a position at or near the intersection between the twoportions contact feature 528, theproximal slider 522 has moved substantially as far proximally as it will move during actuation of theanastomosis tool 300. Further, when theproximal end 516 of theproximal arm 514 has reached that position, thestaple holder 38 and theanvil arm 14 are still in the standby position. Referring also toFIG. 77 , this is time t=2, at which theproximal slider 522 has moved proximally from its position at time t=1, and has reached its most proximal position. Thedistal slider 534 is in substantially the same position that it was in at time t=1. - The user continues to depress the
trigger 308. As theproximal end 516 of theproximal arm 514 continues to move upward, it moves past the intersection between the twoportions contact feature 528, thereby contacting theupper portion 532 of thecontact feature 528. Theupper portion 532 of thecontact feature 528 provides substantially no resistance to the continued rotation of therocker 508, because it is substantially vertical or angled in a proximal direction as it extends upward. Theproximal end 516 of theproximal arm 514 thus moves upward rapidly. Alternately, the speed of the motion of theproximal end 516 of theproximal arm 514 is controlled to be the same as or slower than its speed while it contacts thelower portion 530 of thecontact feature 528. During the upward motion of theproximal end 516 of theproximal arm 514, theproximal slider 522 may move distally at least slightly due to the arcuate motion of theproximal end 516 of theproximal arm 514 relative to the non-arcuateupper portion 532 of thecontact feature 528. - As the
proximal end 516 of theproximal arm 514 moves upward along theupper portion 532 of thecontact feature 528, thedistal end 520 of thedistal arm 518 continues to move downward along the contact surface 548 of thedistal slider 534. As described above, theposts 544 at thedistal end 520 of thedistal arm 518 are spaced apart from one another, such that a gap is present between them. Thedistal arm 518 may contact the contact surface 548 via theposts 544 during at least a portion of its travel. As thedistal end 520 of thedistal arm 518 moves downward, theposts 544 reach thebottom edge 570 of the contact surface 548. Therocker 508, the proximal slider, and thedistal slider 534 are positioned relative to one another and shaped such that theposts 544 reach thebottom edge 570 of the contact surface 548 at substantially the same time that theproximal end 516 of theproximal arm 514 reaches the intersection between the twoportions contact feature 528 of theproximal slider 522. - When the
posts 544 reach thebottom edge 570 of the contact surface 548, they contact the members 600 of theholder 594. As thedistal end 520 of thedistal arm 518 continues to move downward, theposts 544 thereby press the members 600 downward. As a result, the stops 596 are moved out of engagement with thebottom edge 570 of the contact surface 548, such that the stops 596 no longer contact thedistal slider 534. Consequently, the stops 596 no longer restrain thedistal slider 534 against proximal motion under the influence of thespring 540. The width of thelower guide 552 is less than the width of the gap between theposts 544, and thelower guide 552 is substantially aligned with the gap between theposts 544. Thus, after the stops 596 have been pushed below thebottom edge 570 of the contact surface 548 of thedistal slider 534, thelower guide 552 is free to slide through the gap between theposts 544 and through the proximal end of theholder 594. The proximal motion of thedistal slider 534 thus takes up the slack (if any) in thesecond cable 490 connected to thedistal slider 534, then causes thatsecond cable 490 to move proximally. Referring also toFIG. 77 , this is time t=3, at which thedistal slider 534 has rapidly moved proximally from its position at time t=2, and theproximal slider 522 has moved slightly in the distal direction from its position at time t=2. - Referring also to
FIG. 58 , this proximal motion of thesecond cable 490 urges thesled 482, which also is connected to thesecond cable 490, into motion. As described above, at least onechannel 496 is defined in thestaple holder 38, and thesecond cable 490 is guided by a correspondingchannel 496. Thestaple holder 38 is shaped such that thechannel 496 curves and causes thesecond cable 490 to curve back in a proximal direction. Thesecond cable 490 is connected to thesled 482. Thus, the curvature of thechannel 496 causes thesecond cable 490 to curve, such that the proximal motion of thesecond cable 490 pulls thesled 482 distally. In this way, proximal motion of thedistal slider 534 causes thesled 482 to move distally. - Referring also to FIGS. 64 and 68-69, the
sled 482 includes one ormore ramp elements 446, each movable within acorresponding passage 440 in anarm 402 of thestaple holder 38, as described above. Initially, thesled 482 is positioned such that eachramp element 446 is proximal to the mostproximal connector bay 448 connected to thecorresponding passage 440. Thus, as thesecond cable 490 is tensioned and moved proximally by thedistal slider 534, and thesled 482 moves distally as a result, eachramp element 446 moves distally in itscorresponding passage 440. - For convenience in describing the deployment of
staples 464, the motion of oneramp element 446 through thecorresponding passage 440 will be described; the motion of eachadditional ramp element 446 through itscorresponding passage 440 occurs in the same or a similar manner. Referring toFIG. 64 , as theramp element 446 moves distally from its initial position, itsdistal end 474 contacts the mostproximal connector deployer 452. As described above, eachconnector deployer 452 initially is in a first position in which itsouter end 454 extends into thepassage 440. When thedistal end 474 of theramp element 446 contacts the mostproximal connector deployer 452, it urges thatconnector deployer 452 into the correspondingconnector bay 448. Thedistal end 474 of theramp element 446 may be shaped such that itsinner surface 476 curves or angles relative to the direction of travel of theramp element 446. Thus, when thedistal end 474 of theramp element 446 encounters theouter end 454 of the mostproximal connector deployer 452, a component of the force it exerts on theconnector deployer 452 is substantially parallel to the longitudinal centerline of the correspondingconnector bay 448. That centerline may be substantially perpendicular to the direction of travel of theramp element 446, or may be otherwise oriented relative to the direction of travel of theramp element 446. - As a result of contact with the
distal end 474 of theramp element 446, theconnector deployer 452 begins to move through the correspondingconnector bay 448, away from thepassage 440. Aconnector 464 is located in theconnector bay 448, inward from theconnector deployer 452. Thetines 466 of theconnector 464 initially may be biased against at least part of the correspondingconnector bay 448 as described above, or theconnector 464 may otherwise be held within theconnector bay 448 prior to motion of theconnector deployer 452. As theconnector deployer 452 moves, it exerts a force on thecorresponding connector 464, overcoming the force with which theconnector 464 is initially held in place and pushing theconnector 464 inward. As theconnector 464 is urged inward, the registration element 458 (if used) translates along theregistration feature 462 of theconnector bay 448. Theregistration element 458 reduces or eliminates lateral cocking of theconnector deployer 452 during its translation through theconnector bay 448, such that theconnector deployer 452 is maintained in substantially the same orientation throughout its travel. - Referring also to
FIG. 61 (in which the graft vessel and target vessel are not shown for clarity), as theconnector deployer 452 urges theconnector 464 out of theconnector bay 448, thetines 466 of theconnector 464 move out of theconnector bay 448, penetrate theroot 405 of theflap 408 held against theinner surface 450 of thearm 402, then penetrate the wall of thetarget vessel 580. One or more of thearms 402 may be angled relative to a horizontal plane to facilitate connecting the flaps of thegraft vessel 404 to the wall of thetarget vessel 580, where that angle is chosen to place connectors in a desired orientation relative to the surface of thetarget vessel 580. Advantageously, thestaples 464 enter the target vessel substantially perpendicular to it. However, thestaples 464 can enter the target vessel at a different angle, and/or at different angles relative to one another. - After the
tines 464 have completely penetrated the wall of the target vessel, they encounter corresponding staple bending features 572 in theanvil arm 14. The staple bending features 572 are depressions in the surface of theanvil arm 14, aligned with theconnector bays 448 such that at least onetine 466 of at least oneconnector 464 encounters astaple bending feature 572 upon being pushed out of itsconnector bay 448. One or more of the staple bending features 572 may be configured differently, or may be omitted altogether. As theconnector deployer 452 continues to urge theconnector 464 out of theconnector bay 448 and toward theanvil arm 14, thetines 464 of theconnector 464 are pressed into the staple bending features 572. Thus, the force transmitted from theramp element 446 to theconnector deployer 452 presses thetines 464 into the staple bending features 572, causing them to deflect. Thetines 464 may be deflected in any direction suitable for holding theflap 408 to thegraft vessel 404. - When the widest portion of the
distal end 474 of theramp element 446 encounters theouter end 454 of theconnector deployer 452, theconnector deployer 452 reaches the end of its stroke through the connector bay. Theconnector 464 and the corresponding staple bending feature or features 572 are configured such that the deflection of thetines 446, and thus the deployment of theconnector 464, is substantially complete when the correspondingconnector deployer 452 reaches the end of its stroke. Theramp element 446 then continues its motion through thepassage 440 to encounter thenext connector deployer 452, such that thestaples 464 in eacharm 402 are deployed sequentially. Alternately, theramp element 446 andpassage 440 are configured such that theramp element 446 moves in substantially the same direction as thesliders 452, or is otherwise connected to thesliders 452, such that two or more of thesliders 452 are actuated substantially simultaneously. That is, thesliders 452 may be actuated in series, in parallel, or in a different way. For example, thesliders 452 may be selectively actuated, such that a selected number ofstaples 464 can be deployed. The user can deploy a selected number ofstaples 464 based on the size of thegraft vessel 404 or other relevant factors. That is, the staple line (the length along thetarget vessel 580 along whichstaples 464 are deployed) is adjustable. Such adjustment may be performed in any appropriate manner, such as by adjusting the distance traveled by eachramp element 446 during deployment of thestaples 464. Alternately, other mechanisms or structures may be used to deploy thestaples 464 from theconnector bays 448 in a desired sequence. - As described above, the
staple holder 38 includes two spaced-apartarms 402. Aramp element 446 proceeds distally through acorresponding passage 440 in eacharm 402. Further, theconnector bays 448 in eacharm 402 are aligned in a substantially bilaterally symmetric manner. Thus, as thesled 482 translates distally, thedistal end 474 of eachramp element 446 encounters aconnector deployer 452 at substantially the same time, such that aconnector 464 is deployed from eacharm 402 at substantially the same time. As a result, thestaple holder 38 sequentially deploys pairs ofstaples 446 into tissue as theramp elements 446 move distally. Alternately, theconnector bays 448 are staggered, such thatstaples 464 from eacharm 402 are deployed at different times than staples from theother arm 402. - The
sled 482 also includesvein knives 432. Eachvein knife 432 translates through a correspondingvein knife passage 430 defined by afirst channel 426 in thegraft clip 412 and asecond channel 428 in theflap receiving surface 406, as described above. Thedistal end 474 of eachvein knife 432 is sharp. As described above, thevein knives 432 are initially in a first position, where thedistal end 474 of eachvein knife 432 is located proximal to theroot 405 of thecorresponding flap 408. As thesecond cable 490 is tensioned and pulled toward thehandle 302 by thedistal slider 534, thesled 482 moves distally. Thevein knives 432, which are connected to thesled 482 move distally as well through the correspondingvein knife passages 430. - As each
vein knife 432 moves distally, its sharpdistal end 474 engages the proximal edge of theroot 405 of thecorresponding flap 408, entering the tissue of theflap 408 and beginning to make an incision therein. Theserrations 438 on thegraft clip blades 436 assist in holding theflap 408 as thecorresponding vein knife 432 incises it. Alternately, thoseserrations 438 may assist in incising theflap 408, depending on their configuration. In addition, theserrations 438 may assist in holding the excess tissue incised from eachflap 408, after thevein knife 432 has made an incision through the entire flap. Thevein knives 432 do not extend as far in the distal direction as theramp elements 446. Thus, as thesled 482 translates distally, thedistal end 474 of eachramp element 466 reaches any given longitudinal position before theblade 434 of thecorresponding vein knife 432. Consequently, theramp element 466 causes a staple 446 to deploy at a particular longitudinal position before thecorresponding vein knife 432 extends the incision in theflap 408 to that longitudinal position. By stapling before incising at any given longitudinal position, eachflap 408 is held securely as it is cut by thecorresponding vein knife 432. Alternately, at any given longitudinal position, theflap 408 is incised during or before deployment of a staple 446 at that position. Eachvein knife 432 is positioned to cut theflap 408 far enough from the deployedstaples 446 to minimize or eliminate interference with thesestaples 446, but close enough to thestaples 446 to cut away excess tissue on theflap 408 that is not needed for the finished anastomosis. - Referring also to
FIGS. 45 , 58 and 68, thecutter 200 has been freed for translation. Thecutter 200 is urged distally by thereceiver 218, which engages theengagement feature 216 of thecutter 200. Thereceiver 218 may be defined in thesled 482, as described above. As thesled 482 is pulled distally by thesecond cable 490, thereceiver 218 moves distally, thereby urging theengagement feature 216 of thecutter 200 distally. Alternately, thereceiver 218 is not defined in thesled 482. Instead, thereceiver 218 is a separate structure that may be connected to thesled 482, and that is configured to travel along aguide structure 241. Theguide structure 241 is a rail or other structure along which thereceiver 218 slide, and thereceiver 218 interfaces with and translates along the rail. Thus, theguide structure 241 guides the translation of thereceiver 218. Acavity 240 is provided in thestaple holder 38 adjacent to theguide structure 241 to allow for motion of thereceiver 218 along theguide structure 241. Thecavity 240 is sized to allow thereceiver 218 to translate freely. Alternately, theguide structure 241 is a hollow channel defined within thestaple holder 38, such that the walls of the channel guide the translation of thereceiver 218. Alternately, theguide structure 241 may be any other structure or mechanism capable of guiding the translation of thereceiver 218. Theguide structure 241 is substantially aligned with theanvil arm 14. That is, the longitudinal centerline of theguide structure 241 is substantially parallel to the longitudinal centerline of theanvil arm 14. Thus, motion of thereceiver 218 along theguide structure 241 causes translation of theengagement feature 216 and therefore translation of thecutter 200 substantially parallel to the centerline of theanvil arm 14. Thereceiver 218 may be actuated to translate along theguide structure 241 by thesecond cable 490, which transmits force from thehandle 302. Alternately, the actuator may convert stored energy to force that is applied to the cutter. Such stored energy may be provided by a spring, battery, source of compressed gas, or other source. Alternately, any mechanism, structure or method, using stored energy or not, may be used to translate thereceiver 218 along theguide structure 241. The particular mechanism, structure or method used to cause translation of thecutter 200 is not critical to the invention. - The
upper surface 252 of thecutter 200 is substantially planar proximal to theprojection 208. The biasingelement 260 contacts theupper surface 252 of thecutter 200 and biases thecutter 200 downward. Thecutter 200 includes akeel 264 that extends downward. Thekeel 264 may be formed into thecutter 200, or may be a separate component connected to thecutter 200. Thekeel 264 is substantially as wide as the adjacent portion of thecutter 200. However, thekeel 264 may be wider or narrower than the adjacent portion of thecutter 200. Thekeel 264 is positioned at or near the distal end of thecutter 200. Alternately, thekeel 264 may be positioned at a different location on thecutter 200. - Referring to
FIG. 43A , another embodiment of acutter 200 is shown. As described above, thecutter 200 includes at least oneprojection 208 extending substantially upward from a position at or near its distal end, and anengagement feature 216 extending upward from theupper surface 252 of thecutter 200. In this embodiment, thekeel 264 of thecutter 200 is spaced apart from theprojection 208, differing from the embodiment ofFIG. 37-38 in which thekeel 264 is adjacent to theprojection 208. By spacing thekeel 264 apart from theprojection 208, thekeel 264 can project a smaller distance downward while moving theprojection 208 substantially the same amount upward and downward. Consequently, thekeel 264 as a whole can be made smaller. - Referring to
FIG. 43B , another embodiment of acutter 200 is shown. As described above, thecutter 200 includes at least oneprojection 208 extending substantially upward from a position at or near its distal end, and anengagement feature 216 extending upward from theupper surface 252 of thecutter 200. In this embodiment, thecutter 200 includes afirst keel 264 and asecond keel 265. Thefirst keel 264 may be configured similarly to thekeel 264 ofFIG. 43 , and thesecond keel 265 may be configured similarly to thekeel 265 ofFIG. 43A . Thefirst keel 264 extends further below the body of thecutter 200 than thesecond keel 265. A third lower opening (not shown) is defined through alower surface 256 of theanvil 10, in addition to the firstlower opening 254 and the secondlower opening 268. The third lower opening is spaced apart from the secondlower opening 268, and is positioned distal to the secondlower opening 268. Thefirst keel 264 initially extends into the secondlower opening 268, and thesecond keel 265 initially extends into the firstlower opening 254. - As shown in
FIG. 45 , thekeel 264 initially extends into the firstlower opening 254, which is defined through alower surface 256 of theanvil 10. Thekeel 264 may extend completely through the firstlower opening 254, such that its lowest point extends outside theanvil 10. Thekeel 264 is biased downward into the firstlower opening 254 as a result of the downward force exerted on thecutter 200 by the biasingelement 260. While thekeel 264 is biased into the firstlower opening 254, theprojection 208 remains below thecontact surface 206 of theanvil arm 14. In this way, theprojection 208 does not extend out of theanvil arm 14 while theanvil arm 14 is inserted into the wall of a target vessel. Where thecutter 200 ofFIG. 43A is used, thekeel 264 need not extend into or through the firstlower opening 254 as far as thekeel 264 of thecutter 200 ofFIGS. 37-38 . As a result, less clearance for the motion of thekeel 264 need be provided, and thetissue effector 400 may be made more compact. The firstlower opening 254 extends along a fixed length of thelower surface 256 of theanvil 10. As thecutter 200 translates distally, thekeel 264 continues to remain at least partially within the firstlower opening 254, such that theprojection 208 continues to remain below thecontact surface 206 of theanvil arm 14. Initially, thekeel 264 may be positioned proximal to the distal end of the firstlower opening 254. The length of the firstlower opening 254 is selected to cause theprojection 208 to remain below thecontact surface 206 of theanvil arm 14 across that distance. That is, this distance is selected such that theprojection 208 on thecutter 200 does not engage the wall of the target vessel until theprojection 208 is positioned within the circumference of the graft vessel. That is, the connection between the graft vessel and the target vessel substantially defines a closed area, and theprojection 208 is configured to engage the wall of the target vessel within that closed area. In this way, theprojection 208 makes an incision completely within the connection between the graft vessel and the target vessel, completing the anastomosis between the two vessels and minimizing or eliminating leakage at the anastomosis site. While theprojection 208 on thecutter 200 remains below the upper surface of theanvil arm 14, it neither engages nor cuts the wall of the target vessel. - Referring also to
FIG. 46 , thecutter 200 continues to advance distally as thereceiver 218 continues to urge theengagement feature 216 distally. As described above, at least the distal end of thecutter 200 is biased downward. As thecutter 200 advances distally, thekeel 264 encounters the distal end of the firstlower opening 254. This encounter, and the continued proximal translation of thecutter 200, causes thekeel 264 to move upward relative to theanvil arm 14. Thekeel 264 and/or the distal end of the firstlower opening 254 may be constructed to provide a smooth, gradual upward motion of thekeel 264, such as by providing a gradual slope on thekeel 264 and/or the distal end of the firstlower opening 254. Alternately, thekeel 264 and/or the distal end of the firstlower opening 254 may be constructed to allow or cause thekeel 264 to move upward abruptly upon encountering the distal end of the firstlower opening 254. The upward motion of thekeel 264 causes the distal end of thecutter 200 and theprojection 208 to move upward. Thus, the size and position of the firstlower opening 254, including the position of the distal end of the firstlower opening 254, control the motion of thecutter 200 and theprojection 208 in the vertical direction. - Where the
cutter 200 ofFIG. 43A is used, thekeel 264 contacts the distal end of the firstlower opening 254 in the same manner as the cutter ofFIGS. 37-38 . By spacing thekeel 264 apart from theprojection 208, theprojection 208 may be protected from inadvertent contact with the distal end of the firstlower opening 254. The initial position of thecutter 200 relative to the remainder of thetissue effector 400 may be different than that of thecutter 200 ofFIGS. 37-38 , to ensure that theprojection 208 enters the wall of the target vessel at a selected point relative to thetissue effector 400. Where thecutter 200 ofFIG. 43B is used, as thecutter 200 is urged distally, thesecond keel 265 and the firstlower opening 254 are configured such that thesecond keel 265 contacts the distal end of the firstlower opening 254 before thefirst keel 264 can contact the distal end of the secondlower opening 268. In this way, the distal end of thecutter 200 is prevented from contacting the distal end of the secondlower opening 268. - As the distal end of the
cutter 200 moves upward, theprojection 208 moves upward through theupper opening 248 in theanvil arm 14. Thecontact surface 206 of theanvil arm 14 is substantially adjacent to the inner surface of the wall of the target vessel. Thus, upward motion of theprojection 208 through theupper opening 248 and above thecontact surface 206 of theanvil arm 14 causes theprojection 208 to enter the wall of the target vessel. Thecutter 200 continues to move distally, such that thekeel 264 moves out of the firstlower opening 254 completely and contacts thebottom surface 266 of thechannel 246 of theanvil arm 14. Theprojection 208 is sized such that theprojection 208 completely penetrates the wall of the target vessel when thekeel 264 has moved proximally to the firstlower opening 254 and is in contact with thebottom surface 266 of thechannel 246. That is, at least a portion of theprojection 208 passes through the wall of the target vessel and enters the lumen of the target vessel. This initial penetration of the wall of the target vessel defines the starting point of an arteriotomy performed on the target vessel by theprojection 208. The starting point of the arteriotomy is spaced apart from the location on the target vessel at which theanvil arm 14 is inserted, because thecutter 200 and theprojection 208 have moved proximally a selected distance before penetrating or incising the wall of the target vessel. The portion of the wall of the target vessel between the arteriotomy and the insertion point of theanvil arm 14 may be referred to as a tissue bridge. The incision is referred to as an arteriotomy for convenience, and this terminology does not limit the type of anastomosis that may be performed. For example, anastomosis may be performed between two tissue structures that are not blood vessels, such as bile ducts. - The
projection 208 of thecutter 200 enters the wall of the target vessel at a location between thearms 402 of thestaple holder 38. Eacharm 402 holds at least a portion of aflap 408 of thegraft vessel 404 against the wall of the target vessel, such that theprojection 208 enters the wall of the target vessel at a location between theflaps 408. The length of thecutter 200, the position of theprojection 208 on thecutter 200, and the placement of the firstlower opening 254 may be selected such that theprojection 208 enters the wall of the target vessel after at least onestaple 446 is deployed into one of theflaps 408 and the wall of the target vessel. Alternately, theprojection 208 enters the wall of the target vessel before any of thestaples 446 have been deployed, or after all of thestaples 446 have been deployed. Further, the length of thecutter 200, the position of theprojection 208 on thecutter 200, and the placement of the firstlower opening 254 may be selected such that the projection enters the wall of the target vessel at substantially the same time that one ormore vein knives 432 begin to incise the corresponding flaps 408. - As the
sled 482 continues to advance distally, thedistal end 474 of eachramp element 476 actuates eachconnector deployer 452 in turn, causing thesliders 452 to sequentially deploy the correspondingstaples 446 as described above. Additionally, thevein knives 432 continue to move distally as thesled 482 advances distally, lengthening the incision in theroot 405 of eachflap 408. Further, referring also toFIG. 47 , thecutter 200 continues to advance distally as thereceiver 218 continues to urge theengagement feature 216 distally. Thecutter 200 incises the wall of the target vessel at a given longitudinal position at substantially the same time as eachvein knife 432 incises thecorresponding flap 408 at the that longitudinal position. Alternately, the timing of the cutting action of thecutter 200 and thevein knives 432 is different, such that thecutter 200 incises the wall of the target vessel at a given longitudinal position either before or after eachvein knife 432 incises thecorresponding flap 408 at that longitudinal position. - The lower surface of the
keel 264 contacts thebottom surface 266 of thechannel 246 during this translation. The contact between thekeel 264 and thebottom surface 266 of thechannel 246 counteracts the downward bias of the distal end of thecutter 200. In this way, theprojection 208 is maintained above thecontact surface 206 of theanvil arm 14. As thecutter 200 continues to translate distally, theprojection 208 moves through the tissue of the wall of the target vessel in a direction substantially parallel to the longitudinal centerline of theanvil arm 14, and incises the tissue of the wall of the target vessel to create an arteriotomy. Because theprojection 208 is connected to and translated by thecutter 200, which is within the target vessel, the arteriotomy is performed from within the target vessel. The tip of theprojection 208 may maintain substantially the same height relative to thecontact surface 206 of theanvil arm 14 during translation of thecutter 200, or may change its height relative to thecontact surface 206 of the anvil arm, as long as theprojection 208 continues to incise completely through the wall of the target vessel. - Where the cutter of
FIG. 43B is used, the lower surface of thesecond keel 265 and the lower surface of thefirst keel 264 both contact thebottom surface 266 of thechannel 246. Alternately, the lower surface of thefirst keel 264 extends downward enough that the lower surface of thesecond keel 265 does not contact thebottom surface 266 of thechannel 246. - Referring also to
FIG. 48 , a secondlower opening 268 is defined through thelower surface 256 of theanvil arm 14. The secondlower opening 268 is distal to and substantially aligned with the firstlower opening 254. Thecutter 200 continues to advance distally as thereceiver 218 continues to impel theengagement feature 216 distally. As a result of this translation, thekeel 264 encounters the proximal end of the secondlower opening 268. Because the distal end of thecutter 200 is biased downward, thekeel 264 moves downward at least partially into the secondlower opening 268. The downward motion of thekeel 264 causes the distal end of thecutter 200 and theprojection 208 to move downward. Thekeel 264 and/or the proximal end of the secondlower opening 268 may be constructed to provide a smooth, gradual downward motion of thekeel 264, such as by providing a gradual slope on thekeel 264 and/or the proximal end of the secondlower opening 268. Alternately, thekeel 264 and/or the proximal end of the secondlower opening 268 may be constructed to allow or cause thekeel 264 to move downward abruptly upon encountering the proximal end of the secondlower opening 268. Alternately, where thecutter 200 ofFIG. 43B is used, thefirst keel 264 moves as least partially into the third lower opening 269, and thesecond keel 264 moves at least partially into the secondlower opening 268. The downward motion of the distal end of thecutter 200 causes theprojection 208 to retract into or completely through theupper opening 248, such that theprojection 208 no longer encounters the tissue of the wall of the target vessel. Theprojection 208 may be urged downward completely into thechannel 246, depending on the depth of thechannel 246 and the height of theprojection 208. - Alternately, the upper tip of the
projection 208 may remain within theupper opening 248. Thecutter 200 may stop its distal translation at substantially the same time that theprojection 208 retracts completely into theupper opening 248, or may continue to translate distally within thechannel 246 before coming to a stop. Alternately, the secondlower opening 268 is not provided, and only the firstlower opening 254 extends through thelower surface 156 of theanvil arm 14 into thechannel 246. In such a configuration, thecutter 200 is refracted in the proximal direction after the arteriotomy is formed, until thekeel 264 moves downward into the firstlower opening 254 and theprojection 208 consequently retracts completely into theupper opening 248. - The
sled 482 continues to move distally, such that thedistal end 474 of theramp element 446 actuates the mostdistal connector deployer 452 and deploys thecorresponding staple 446. Referring also toFIG. 76 , the connection between the end of thegraft vessel 404 and thetarget vessel 580 is then complete. Thesled 482 continues to translate, such that eachvein knife 432 then moves completely through thecorresponding flap 408. A portion of eachflap 408 continues to be held between eachgraft clip 412 and correspondingflap receiving surface 406. Thus, when theroot 405 of eachflap 408 has been completely incised through by thecorresponding vein knife 432, thestaple holder 38 no longer holds thegraft vessel 404, and is freed from the anastomosis site. - Referring to
FIG. 73 , therocker 508 completes its travel when thedistal end 520 of thedistal arm 516 contacts one or more of theribs 556 in thehandle 302. This contact prevents further downward motion of thedistal arm 518, and thereby causes therocker 508 to cease its motion. Alternately, at least a portion of thedistal arm 516 and/or theproximal arm 514 contact a stop or other structure in thehandle 302 which obstructs further motion of therocker 508. Alternately, the motion of therocker 508 is stopped in a different way, such as by a braking or clutch mechanism. Thus, the corresponding travel of thesecond cable 490 and theconnected sled 482 cease as well. After therocker 508 has completed its travel, theupper portion 532 of thecontact feature 528 of theproximal slider 522 contacts theproximal end 516 of theproximal arm 514. Thespring 546 biases theproximal slider 522 distally. Thus, theupper portion 532 of thecontact feature 528 is pressed against theproximal end 516 of theproximal arm 514, holding theproximal arm 514 and therocker 508 in place and substantially preventing rotation of therocker 508 in a direction opposite to its previous motion. Alternately, theproximal slider 522 does not contact therocker 508 after the travel of therocker 508 is complete. At substantially the same time as the motion of therocker 508 stops, thelower guide 552 of thedistal slider 534 contacts astop 553 defined in or connected to thehandle 302. Thestop 553 may be integrated with at least one of theribs 556. Thestop 553 is positioned to interfere with further proximal motion of thedistal slider 534, such that contact between thelower guide 552 and thestop 553 causes thedistal slider 534 to cease moving proximally. Alternately, thestop 553 is not used, and thedistal slider 534 is allowed to continue to move proximally after deployment of thestaples 446. Referring also toFIG. 77 , this is time t=4, at which thedistal slider 534 has moved proximally from its position at time t=3, and the proximal slider has moved slightly distally from its position at time t=3. - As described above, the
distal slider 534 may include averification stub 560 that extends substantially upward from the upper end of thedistal slider 534 through aslot 562 in thehandle 302. Initially, when thedistal slider 534 is in its most distal position, theverification stub 560 is also in its most distal position. As thedistal slider 534 translates proximally during actuation of theanastomosis tool 300, theverification stub 560 also translates proximally. Thus, after theanastomosis tool 300 has been actuated and thedistal slider 534 has moved to its most proximal position, theverification stub 560 has moved to its most proximal position as well. By visually inspecting the position of theverification stub 560, the user can confirm whether theanastomosis tool 300 has been completely actuated. In addition, thedistal end 474 of at least oneramp element 446 may be visible after actuation of theanastomosis tool 300 if thedistal end 442 of thepassage 440 is open, providing another visual indication that theanastomosis tool 300 has been completely actuated. The distal end of the firstlower opening 254 and the proximal end of the secondlower opening 268 control the motion of theprojection 208 and thereby control the penetration of the wall of the target vessel. That is, the distance between the distal end of the firstlower opening 254 and the proximal end of the secondlower opening 268 determines the length of the arteriotomy. - Alternately, where the
snap arm 606 is used instead of the cam lock to hold acorresponding graft clip 412 in the closed position, thedistal end 474 of thecorresponding ramp element 446 extends out of thedistal end 442 of thepassage 440 to disengage thecatch 608 of thesnap arm 606. That is, thelobe 610 of thesnap arm 606 is positioned relative to thedistal end 442 of thepassage 440 such that thedistal end 474 of thecorresponding ramp element 446 encounters thelobe 610 near the end of the travel of the ramp element, pushing thelobe 610 out of engagement of thearm 402 and thus disengaging thecatch 608 from thearm 402. Thecorresponding graft clip 412 is thereby free to move out of the closed position, freeing theflap 408 held by thatgraft clip 412. In such an embodiment, thevein knives 432 may be omitted, because theflaps 408 are freed in their entirety. Further, thespikes 410 are omitted, such that theflaps 408 are not held in place on theflap receiving surface 406 after thesnap arm 606 is disengaged from thearm 402. - After performing the arteriotomy, the
cutter 200 is in a distally-extended position. Thecutter 200 remains in that position as theanvil arm 14 is removed from thetarget vessel 580, where thetissue bridge 582 separates the anastomosis site from thehole 584 in the wall of thetarget vessel 580 through which theanvil arm 14 entered thetarget vessel 580. Thus, theprojection 208 does not extend out of theupper opening 248 during removal of theanvil arm 14 from thetarget vessel 580. Alternately, after performing the arteriotomy, thecutter 200 may be moved proximally within thechannel 246 in theanvil arm 14 before removing theanvil arm 14 from thetarget vessel 580. - The
tissue effector 400 is then returned to the open position from the closed position, to allow theanvil arm 14 to be withdrawn from thetarget vessel 580. After thetrigger 308 has been depressed to deploy one ormore connectors 464, thedistal arm 518 of therocker 508 has deflected at least a portion of theholder 594. As a result, the deflectedholder 594 exerts an opposing bias against thedistal arm 518 of therocker 508. When the user releases thetrigger 308, thebiased holder 594 then acts against thedistal arm 518, pushing it upward and causing therocker 508 to rotate about therocker axle 510. As a result, theproximal arm 514 of therocker 508 moves downward toward its original position. Thus, theproximal end 516 of theproximal arm 514 moves downward against theupper portion 532 of thecontact feature 528 of theproximal slider 522, and continues to move downward past the intersection between the twoportions contact feature 528. As theproximal end 516 of theproximal arm 514 moves past that intersection to contact thelower portion 530 of thecontact feature 528, theproximal slider 522 is freed to move distally a small amount due to the bias of thespring 546. This proximal motion relaxes the tension on thefirst cable 480. As a result, the biasingelement 475 pushes thestaple holder 38 away from theanvil 10, returning thetissue effector 400 to the open position. Thetissue effector 400 thus no longer clamps the wall of thetarget vessel 580, and theanvil arm 14 can be removed from the lumen of thetarget vessel 580. The spacing between thestaple holder 38 and theanvil 10 in the open position is selected to ensure adequate clearance for separation of thetissue effector 400 from thetarget vessel 580. For example, thestaple holder 38 is moved far enough from theanvil 10 such that thespikes 410 are fully removed from theflaps 408 before theanvil arm 14 is removed from thetarget vessel 580. Alternately, thetissue effector 400 is returned to the open position in another manner. When theprojection 208 is retracted out of the tissue of the wall of the target vessel, the distal end of the arteriotomy is defined, and the arteriotomy is complete. Thus, the anastomosis is complete as well. - Referring also to
FIG. 74 , the completed anastomosis between thegraft vessel 404 and thetarget vessel 580 remains. Thehole 584 in the wall of thetarget vessel 580 through which theanvil arm 14 entered thetarget vessel 580 is small enough to prevent significant bleeding through the puncture site after theanvil arm 14 has been withdrawn. Alternately, thehole 584 is closed by hand suturing. Alternately, thehole 584 is closed with a biocompatible glue, adhesive or the like. Alternately, thehole 584 is closed with a clip, clamp, or other implantable device that remains on the target vessel. Such a device may be positioned on the outer surface and/or inner surface of the target vessel, and may extend into thehole 584. A device for closing thehole 584 may be constructed from nitinol or other superelastic or pseudoelastic material, or from stainless steel or other material, where that device moves between a first configuration and a second configuration during deployment, and where the second configuration holds thehole 584 closed. Thehole 584 is less than substantially 2 mm wide, and advantageously less than 1 mm wide. - As described above, the
cutter 200 incises the wall of the target vessel while thestaple holder 38 is stapling or otherwise connecting the graft vessel to the target vessel, as described in greater detail below. Alternately, thestaple holder 38 may completely staple or otherwise connect the graft vessel to the target vessel before thecutter 200 is urged forward, such that the two vessels are connected before thecutter 200 makes an incision between them. Alternately, thecutter 200 incises the wall of the target vessel before thestaple holder 38 has stapled or otherwise connected the graft vessel to the target vessel. - Referring to
FIG. 49 , a different embodiment of theanvil 10 also includes acutter 200 moveable relative to theanvil 10 for making an incision in the wall of a target vessel. Theanvil 10,anvil arm 14,staple holder 38, and other components are substantially as described above with regard toFIGS. 34-38 and 44-49. In this embodiment, at least the distal end of thecutter 200 is biased upward. In other regards, the actuation of theanastomosis tool 300, the operation of the mechanisms within thehandle 302, and the operation of thetissue effector 400 are substantially as described above. Referring toFIGS. 35 and 49 , theanvil insert 222 is connected to theanvil 10. Anaperture 230 is defined through the distal end of theanvil insert 222 into thecavity 228 defined within theanvil insert 222, connecting thechannel 246 to thecavity 228. Thecutter 200 extends through theaperture 230 in theanvil insert 222, such that the distal end of thecutter 200 is positioned within thechannel 246 and the proximal end of thecutter 200 is positioned within thecavity 228. Acam 232 is positioned within thecavity 228 above theaperture 230. Alternately, thecam 232 may be positioned differently relative to theaperture 230. Thecam 232 is a structure used in controlling the motion of thecutter 200, as is described in greater detail below. - At least the distal end of the
cutter 200 may be biased upward. This biasing may be performed by any appropriate structure or mechanism, such as by one or more springs (not shown). Such a spring or springs may act in compression to push the distal end of thecutter 200 upward, or may act in tension to pull the distal end of the cutter upward. As another example, thecutter 200 may be constructed from an elastic or superelastic material that is formed in such a way as to produce an upward bias. Theentire cutter 200 may be biased upward, if desired. At least the distal end of thecutter 200 is biased upward during the translation of thecutter 200 along theanvil arm 14. Alternately, thecutter 200 is not biased, either upward or downward. Instead, thecutter 200 is urged upward and downward at different locations during its translation by the interaction between at least one cam follower on thecutter 200 and at least thecam 232. - As shown in
FIG. 49 , the distal end of theanvil arm 14 is spaced apart from thestaple holder 38. Theanvil arm 14 is inserted through the wall of the target vessel, as described above, such that thecontact surface 206 of theanvil arm 14 is in substantial contact with the inner wall of the target vessel. Next, referring toFIG. 50 , thestaple holder 38 andanvil 10 are moved relative to one another into the standby position, as described above. In the standby position, thecutter 200 is freed for translation along thechannel 246, because thetip 212 of thesafety feature 210 no longer engages thesafety recess 214 of thecutter 200. At least the distal end of thecutter 200 is biased upward, and thecam 232 limits the upward motion of thecutter 200 by contacting at least a portion of theupper surface 252 of thecutter 200. Thecam 232 controls the motion of the distal end of thecutter 200 in the vertical direction as thecutter 200 translates within thechannel 246. Because theprojection 208 is fixed to thecutter 200, thecam 232 also controls the motion of theprojection 208 in the vertical direction, and thus controls the location at which theprojection 208 encounters the wall of the target vessel. - Referring also to
FIG. 51 , after thecutter 200 has been freed for translation, it is urged distally by thereceiver 218 as described above. Afirst cam follower 242 is defined on theupper surface 252 of thecutter 200. Thefirst cam follower 242 is a raised structure formed into theupper surface 252 of thecutter 200. Alternately, thefirst cam follower 242 is a separate structure or mechanism constructed separately from thecutter 200 and later connected to thecutter 200. Alternately, thefirst cam follower 242 may be located on a surface of thecutter 200 in addition to or instead of itsupper surface 252, depending on the position and configuration of thecam 232. Thefirst cam follower 242 may be shaped as a trapezoid or similar shape, or may be shaped differently. - The
cam 232 is fixed, and thefirst cam follower 242 is raised relative to theupper surface 252 of thecutter 200. At least the distal end of thecutter 200 is biased upward. Thus, as thecutter 200 translates distally, thecam 232 engages thefirst cam follower 242 and causes thecutter 200 to move downward. Thecam 232 and thefirst cam follower 242 are shaped to smoothly engage each other. Alternately, thefirst cam follower 242 is shaped to induce thecutter 200 to abruptly move downward when thefirst cam follower 242 initially encounters thecam 232. The height of thefirst cam follower 242 relative to thecontact surface 206 of theanvil arm 14 determines the distance that the distal end of thecutter 200 is moved downward. As described above, thecutter 200 may include akeel 264 or similar projection extending downward. As the distal end of thecutter 200 moves downward, thekeel 264 or other projection moves into the firstlower opening 254. In this embodiment, the firstlower opening 254 does not control the motion of thecutter 200; instead, it provides a space for thekeel 264 to move downward without interfering with the vertical motion of the distal end of thecutter 200. If thekeel 264 is omitted, the firstlower opening 254 and the secondlower opening 268 may be omitted as well. - The connection between the graft vessel and the target vessel substantially defines a closed area, and the
projection 208 is configured to engage the wall of the target vessel within that closed area. That is, the end of the graft vessel has a perimeter that contacts the side of the target vessel, such that the perimeter of the end of the graft vessel defines a closed area on the wall of the target vessel. In this way, theprojection 208 makes an incision completely within the connection between the graft vessel and the target vessel, completing the anastomosis between the two vessels and minimizing or eliminating leakage at the anastomosis site. While theprojection 208 on thecutter 200 remains below thecontact surface 206 of theanvil arm 14, it neither engages nor cuts the wall of the target vessel. Thus, thefirst cam follower 242 is sized to translate the tip of theprojection 208 below thecontact surface 206 of theanvil arm 14 for a selected distance such that theprojection 208 does not engage the tissue of the target vessel until theprojection 208 is positioned to enter the closed area on the wall of the target vessel defined by the perimeter of the end of the graft vessel. - Referring also to
FIG. 52 , thecutter 200 continues to advance distally as thereceiver 218 continues to impel theengagement feature 216 distally. Thus, thefirst cam follower 242 of thecutter 200 advances distally relative to thecam 232. As described above, at least the distal end of thecutter 200 is biased upward. Thefirst cam follower 242 decreases in height at its proximal end. Thus, as the upwardly-biasedfirst cam follower 242 moves distally relative to thecam 232, thecam 232 and thefirst cam follower 242 gradually disengage, causing both the distal end of thecutter 200 and theprojection 208 to move upward. Thefirst cam follower 242 is constructed to provide a smooth, gradual upward motion of the distal end of thecutter 200 and theprojection 208, such as by providing a gradual slope between anupper surface 250 of thefirst cam follower 242 and anupper surface 252 of thecutter 200. Alternately, thefirst cam follower 242 may be constructed to allow the distal end of thecutter 200 and theprojection 208 to abruptly snap upward as thefirst cam follower 242 moves distal to thecam 232. - As the distal end of the
cutter 200 moves upward, theprojection 208 moves upward through theupper opening 248 in theanvil arm 14. Thecontact surface 206 of theanvil arm 14 is adjacent to the inner surface of the wall of the target vessel. Thus, upward motion of theprojection 208 through theupper opening 248 causes theprojection 208 to enter the wall of the target vessel. Theprojection 208 is sized, and thefirst cam follower 242 andcam 232 are shaped, such that the upward motion of theprojection 208 after thefirst cam follower 242 has moved distal to thecam 232 causes theprojection 208 to completely penetrate through the wall of the target vessel. That is, at least a portion of theprojection 208 passes through the wall of the target vessel and enters the lumen. This initial penetration of the wall of the target vessel defines the starting point of an arteriotomy performed on the target vessel by theprojection 208. The starting point of the arteriotomy is spaced apart from the location on the target vessel at which theanvil arm 14 is inserted, resulting in a tissue bridge therebetween. - Referring also to
FIG. 53 , thecutter 200 continues to advance distally as thereceiver 218 continues to impel theengagement feature 216 distally. Theupper surface 252 of thecutter 200 may contact thecam 232 during this motion, because the distal end of thecutter 200 continues to be biased upward. As thecutter 200 translates, theprojection 208 moves through the tissue of the wall of the target vessel in a direction substantially parallel to the longitudinal centerline of theanvil arm 14. In this way, theprojection 208 incises the tissue of the wall of the target vessel to create an arteriotomy. The tip of theprojection 208 may maintain substantially the same height relative to thecontact surface 206 of theanvil arm 14 during its distal translation, or may change its height relative to thecontact surface 206 of theanvil arm 14, as long as the tip of theprojection 208 remains in the lumen of the target vessel during that translation. - Referring also to
FIG. 54 , asecond cam follower 244 is defined on theupper surface 252 of thecutter 200, proximal to and spaced apart from thefirst cam follower 242. Alternately, a single cam follower is defined on theupper surface 252 of thecutter 200, where that single cam follower includes a feature corresponding to thefirst cam follower 242, a feature corresponding to thesecond cam follower 244, and a section of reduced height between them corresponding to theupper surface 252 of thecutter 200. Thecutter 200 continues to advance distally as thereceiver 218 continues to impel theengagement feature 216 distally. As a result of this motion, thesecond cam follower 244 contacts thecam 232. Engagement between thesecond cam follower 244 and thecam 232 pushes the distal end of thecutter 200 downward. The shape and size of thesecond cam follower 244 andcam 232 are selected such that the distal end of thecutter 200 is pushed downward far enough to cause theprojection 208 to retract into theupper opening 248. Theprojection 208 may be urged downward completely into thechannel 246, depending on the depth of thechannel 246 and the height of theprojection 208. Alternately, the upper tip of theprojection 208 may remain within theupper opening 248. Thecutter 200 may stop its distal translation at substantially the same time that theprojection 208 retracts completely into theupper opening 248, or may continue to translate distally within thechannel 246 before coming to a stop. - When the
projection 208 is retracted out of the tissue of the wall of the target vessel, the distal end of the arteriotomy is defined, and the arteriotomy is complete. The distance between thefirst cam follower 242 and thesecond cam follower 244, and the shape of thecam followers cam follower upper surface 252 of thecutter 200 sufficient to cause theprojection 208 to be pushed out of contact with the wall of the target vessel. The distance between these locations defines the length of the arteriotomy. Thus, thecam followers projection 208 and control the penetration of the wall of the target vessel. - After performing the arteriotomy, the
cutter 200 is in a distally-extended position. Thecutter 200 remains in that position as theanvil arm 14 is removed from the target vessel. Alternately, after performing the arteriotomy, thecutter 200 may be moved proximally within thechannel 246 before removing theanvil arm 14 from the target vessel. Theanvil arm 14 is removed from the target vessel after the anastomosis between the graft vessel and the target vessel has been completed. The hole at the puncture site and its closure are substantially as described above. - Alternately, the
cutter 200 is initially in a distally-extended position, and retracted proximally in order to make an incision in the wall of the target vessel. Similarly, thesled 482 is initially at its most distal location. The structures and mechanisms are substantially as described above, but operated in substantially the reverse order as described above. In this embodiment, thechannels 496 in thestaple holder 38 are not needed, nor it is necessary to reverse the direction of motion of thesecond cable 490 as applied to thesled 482; rather, thesled 482 is deployed by pulling it proximally with thesecond cable 490. Thus, thesecond cable 490 may be connected to the proximal end or other portion of thesled 482. Alternately, thecutter 200 and theprojection 208 may be moved in a different way in order to incise the tissue of the wall of the target vessel. Further, this embodiment is particularly suited for the use of acutter 200 having a sharp distal end that initially extends out of the distal end of theanvil arm 14 in order to puncture the target vessel, after which thecutter 200 is retracted proximally to move its sharp distal end into theanvil arm 14. - Where
multiple projections 208 are provided on thecutter 200 as shown inFIGS. 39-43 , thecutter 200 need not be translated as far to make an incision in the wall of the target vessel as it would if only a single projection were used. Because theprojections 208 are spaced apart from each other along the direction of translation of thecutter 200, eachprojection 208 is able to form a portion of the incision during translation of thecutter 200. Thus, by translating eachprojection 208 across a distance less then the intended length of the entire incision, the complete incision can be formed. The distance that thecutter 200 is translated to form the incision is related to the distance between theprojections 208. That is, because eachprojection 208 forms a portion of the incision, nosingle projection 208 need be translated along the entire length of the incision. - Alternately, where
multiple projections 208 are utilized, theprojections 208 may be inserted into the wall of the target vessel, after which energy is applied to theprojections 208 via thecutter 200 or directly in order to create an incision in the wall of the target vessel. In such an embodiment, an energy source (not shown) is connected to thecutter 200. For example, an ultrasound generator (not shown) may be connected to thecutter 200 and to the energy source. The ultrasound generator may be a piezoelectric crystal, as is standard, or a different structure or mechanism. Electrical energy may be applied to the ultrasound generator from the energy source, thereby causing the ultrasound generator to vibrate theprojections 208. Thus, energy may be applied from the energy source to the ultrasound generator after theprojections 208 have been inserted into the wall of the target vessel, causing theprojections 208 to move and thereby create an incision. Advantageously, a plurality ofprojections 208 spaced relatively close to one another are utilized. Other methods may be used to vibrate, move or oscillate theprojections 208. - Alternately, the length of the arteriotomy created by and the number of
connectors 464 deployed by thetissue effector 400 are adjustable. By controlling these parameters, graft vessels of different diameters can be attached to a target vessel within a small range of angles relative to the graft vessel. The cross-sectional area of the connection between the graft vessel and the target vessel thus can be controlled across a range of two or more sizes while providing for a substantially fixed angle between the target vessel and the graft vessel. - The number of
connectors 464 deployed by thetissue effector 400 can be controlled in any appropriate manner. As one example, by varying the stroke of thesled 482 and therefore the length along eachpassage 440 that is traversed by thecorresponding ramp element 446 of thesled 482, the number ofconnectors 464 deployed as a result of motion of thesled 482 can be controlled. Control of the stroke of thesled 482 may be accomplished in any appropriate manner. For example, a control (not shown) connected to thehandle 302 may allow the selection of a particular number ofconnectors 464 for deployment. Such a control may interact with thesecond cable 490 and/or other components of or connected to thehandle 302, in order to restrict the length that thesecond cable 490 moves upon actuation. By restricting the motion of thesecond cable 490, the stroke of thesled 482 is controlled, and hence the number ofconnectors 464 deployed is controlled. As another example, a set of controllable stops (not shown) may be provided within thetissue effector 400. Each stop is positioned in proximity to aconnector bay 448, and is moveable between a first position that is out of thepassage 440 adjacent to theconnector bay 448 and a second position that is at least partially into thepassage 440. In the second position, the stop contacts and prevents further distal motion of thecorresponding ramp element 446 of thesled 482. The control interacts with the stops, such that when the control is used to select a particular number ofconnectors 464 for deployment, at least one stop is moved to its second position into apassage 440 of thetissue effector 400. Each stop that is moved to its second position corresponds to theconnector bay 448 from which the last of the selected number ofconnectors 464 is to be deployed. Other mechanisms, structures or methods may be used to control the number ofconnectors 464 that are deployed. - Similarly, the length of the arteriotomy is controlled to correspond to the length of tissue that is connected by the selected number of
connectors 464. The length of the arteriotomy can be controlled by controlling the motion of thecutter 200. The motion of thecutter 200 can be controlled in several ways. As one example, theopenings anvil arm 14 can be changed both in length and position, to ensure that the arteriotomy is made to the correct length in the correct position. Theopenings openings openings openings cutter 200. -
FIGS. 17-23 illustrate analternate anvil 100 that is used with aclamp 102 for controlling an incision site during an anastomosis procedure. As shown inFIGS. 17 and 18 , theanvil 100 includes ananvil arm 104 and ahandle 106. Theclamp 102 is slidable on thehandle 106 to clamp the tissue of thetarget vessel 30 between theclamp 102 and theanvil arm 104. As with theanvil arm 104 described above, theanvil arm 104 includes two rows of staple bending features 108 in the form of recesses positioned in two parallel rows along a top surface of theanvil arm 104. Theclamp 102 has acentral opening 110. Once the tissue of the target vessel wall has been trapped between theclamp 102 and theanvil arm 104, an incision may be made through the target vessel wall and the edges of the incision are controlled by the combination of theanvil arm 104 and theclamp 102. - As shown in
FIG. 19 , a continuous anastomosisstaple device 114 may be used to connect thegraft vessel 32 to thetarget vessel 30 at the anastomosis site. Thestaple device 114 as shown inFIG. 19 includes a plurality of linkages forming a tubular configuration and a plurality of staple ends extending from the linkages.FIGS. 20-22 illustrate how the staple ends 116 of thestaple device 114 are positioned in the end of thegraft vessel 32 and are inserted through theincision 118 in the target vessel and bent over by contact with the staple bending features 108 of the anvil. As shown inFIG. 22 , the opposite ends 120 of thestaple device 114 are folded over to complete the anastomosis.FIG. 23 illustrates a completed anastomosis performed according to the steps illustrated inFIGS. 19-22 . -
FIGS. 24-27 illustrate an alternate example of ananvil arm 14 d having acutting wire 124 for forming the incision in the wall of thetarget vessel 30. Thecutting wire 124 may be used to form an incision before, during or after performing an end-to-side anastomosis procedure. Referring particularly toFIGS. 26-27 , for forming the incision after the anastomosis procedure, aclamp 126 is used to trap the tissue at the anastomosis site between theclamp 126 and theanvil arm 14 d prior to performing the incision. The incision is spaced apart from the entry point of theanvil arm 14 d into the target vessel, creating a tissue bridge between the incision made in the wall of the target vessel and the entry point of theanvil arm 14 d into the target vessel. A portion of the contact between the anastomosed graft vessel and target vessel extends across the tissue bridge, such that the incision is located within the closed area defined by the contact between the perimeter of the end of the graft vessel and the wall of the target vessel. -
FIG. 28 shows asystem 140 for controlling a tissue site and performing anastomosis. For purposes of clarity, the staple holder and staples have been omitted fromFIG. 28 . Thesystem 140 includes ananvil arm 142, acutter 144, and agraft vessel holder 146 all mounted on ahandle 148. Theanvil arm 142 is mounted on thehandle 148 and connected to afirst actuator 150 that allows the anvil to be moved downward against the bias of a spring inside the handle. Thecutter 144 may be spring biased or fixed and is positioned on thehandle 148 directly above theanvil arm 142. Thegraft vessel holder 146 includes two fixedarms 152 and twomovable arms 154. The twomovable arms 154 are connected to asecond actuator 156 on thehandle 148. Depression of thesecond actuator 156 against the bias of a spring within the handle causes themovable arms 154 to be moved downward away from the fixed arms to receive portions of a graft vessel between the movable and fixed arms. - The operation of the
system 140 ofFIG. 28 is shown in the cross sectional views ofFIGS. 29-31 . As shown inFIG. 29 , an end of agraft vessel 32 is split so that each half of thegraft vessel 32 can be held between afixed arm 152 and amovable arm 154. In order to load thegraft vessel 32 into thesystem 140, thefirst actuator 150 and thesecond actuator 156 are depressed to move theanvil arm 142 and themovable arms 154 downward. Thesplit graft vessel 32 is then inserted between the fixed andmovable arms second actuator 156 is released to trap the ends of thegraft vessel 32, as shown inFIG. 30 . Theanvil arm 142 is then inserted into thetarget vessel 30 in the same or similar manner as described above. - Once the anvil has been inserted in the
target vessel 30 as shown inFIG. 30 , thefirst actuator 150 is released to allow the anvil to move upward to tent the wall of the target vessel.FIG. 31 illustrates thetented target vessel 30 positioned adjacent the split and trappedgraft vessel 32 in a position for performing anastomosis. Thestaple holders 38 are then advanced in the direction of the arrows D toward opposite sides of the anvil to staple the graft vessel and target vessel together. Thestaple holders 38 may hold a staple strip with an expandable backbone as shown inFIGS. 10A and 10B , or may instead or additionally hold different types of staples not connected to a backbone. Thestaple holders 38 may be provided with movable pins which allow the spacing between the staples to be adjusted depending on a size of the graft vessel used. Once the staples have been placed, theanvil arm 142 is removed and thecutter 144 makes an incision in the target vessel before or during removal of the anvil. - As described above, staple bending features are provided on the anvil and staples are provided at an exterior of the tissue. Alternately, the staples and/or staple holding strips may be positioned on the anvil and an exterior member with staple bending features may be moved toward the anvil to bend the ends of the staples and secure the graft and target vessels together.
-
FIGS. 32-33 illustrate the use of analternate anvil 130 for controlling the tissue at an anastomosis site. Theanvil 130 includes alongitudinal opening 132 extending through theanvil 130 for application of a plurality of conventional sutures at the anastomosis site. According to this method, theanvil 130 is inserted into thetarget vessel 30 and pulled against the interior wall of thetarget vessel 30, tenting the target vessel as shown inFIG. 33 .Sutures 134 are then passed through theopening 132 in theanvil 130 and through the tissue of the target vessel wall on opposite sides of theanvil 130. Once thesutures 134 are placed as shown inFIG. 33 , an incision is made in the target vessel along a center of theanvil 130. A center portion of each of thesutures 34 is then pulled out through the incision in the target vessel and cut so that an even row of sutures is provided along each of the sides of the incision. This system eliminates the tedious procedure of placing each individual suture very close to the edge of the incision in the very thin and flexible target vessel wall. Each of thesutures 134 is connected to a graft vessel in a conventional manner completing the anastomosis. The anvil as shown inFIGS. 32-33 allows quick and easy placement of a plurality of sutures in a very even manner close to the edge of the incision. For example, the sutures of a conventional anastomosis are generally within about one millimeter of the edge of the incision and are advantageously within 0.5 millimeters of the edge of the incision. - In an alternate embodiment, the
cutter 200 does not include one ormore projections 208. Instead, thecutter 200 includes or is connected directly or indirectly to an energy source (not shown), which is used to create an opening in the wall of the target vessel. For example, an emitter of laser or RF energy, or another type of energy, may be connected to thecutter 200 and to the energy source. As thecutter 200 translates along theanvil arm 14, it translates the emitter of laser or RF energy relative to the wall of the target vessel. The emitter of laser or RF energy is selectively actuated to transmit energy into the wall of the target vessel during translation of thecutter 200, thereby creating an opening therein. The energy source may transmit a first type of energy to the emitter or other mechanism, which is converted by the emitter into a second type of energy delivered into the wall of the target vessel. Alternately, thecutter 200 may include aprojection 208 and additionally be connected to an energy source that is selectively actuated in order to assist in creating an opening in the wall of the target vessel. - In an alternate embodiment, the
cutter 200 does not translate through theanvil arm 14. Instead, thecutter 200 is spatially removed from theanvil arm 14, and creates an opening in the wall of the target vessel before or after theanvil arm 14 is inserted into the target vessel. In one example of such an embodiment, theanvil arm 14 is inserted into a hole in the wall of the target vessel and thestaple holder 38 deploys staples or other connectors to connect the graft vessel to the target vessel, as described above. Theanvil arm 14 is removed, and anindependent cutter 200 is then introduced through the hole in the wall of the target vessel. Thecutter 200 may be configured as described above, including aprojection 208 extending therefrom, or may be configured differently. Thecutter 200 is manipulated relative to the connection between the target vessel and the graft vessel to create an opening at the junction therebetween. That is, registration is maintained between thecutter 200 and the junction between the end of the graft vessel and the wall of the target vessel. In order to position and manipulate thecutter 200 to create an opening at the location of the junction between the target vessel and the graft vessel, an imaging device (not shown) or other device may be connected to thecutter 200 or utilized in conjunction with thecutter 200. For example, a standard intravascular ultrasound unit may be connected to or used in conjunction with thecutter 200. The intravascular ultrasound unit is connected to a display device (not shown) visible to the operator. The operator controls the intravascular ultrasound unit to visualize the interior of the target vessel and the surrounding area, thereby locating the junction between the target vessel and the graft vessel and allowing thecutter 200 to be controlled to incise an opening in the wall of the target vessel within the closed area on the wall of the target vessel defined by the perimeter of the end of the graft vessel, thereby allowing blood to flow through the opening into the target vessel. A different visualization device or devices may be inserted into or positioned outside of the target vessel to locate the junction with the graft vessel. Thecutter 200 and any visualization device present in the lumen of the target vessel are then removed from the lumen of the target vessel, and the opening in the wall of the target vessel through which they were removed is sealed. - In another example of such an embodiment, the
anvil arm 14 is inserted into a hole in the wall of the target vessel and thestaple holder 38 deploys staples or other connectors to connect the graft vessel to the target vessel, as described above. Theanvil arm 14 is removed, and the hole in the wall of the target vessel is removed. A cannula (not shown) is inserted into the lumen of the graft vessel through the free end of the graft vessel, and a stylet (not shown) is inserted through the lumen of the cannula. The cannula and the stylet are surgical instruments that are well known in the art. The stylet has a distal end configured to penetrate the wall of the target vessel. Thus, a sharp point, blade, or other penetrating member may be formed into or connected to the distal end of the stylet. The cannula may be inserted into the lumen of the graft vessel such that its distal end contacts the outer wall of the target vessel. After the stylet has been inserted into the cannula, a force is exerted on the stylet to cause its distal end to penetrate the wall of the target vessel. Consequently, an opening is created between the graft vessel and the target vessel within the circumference of the end of the graft vessel. The cannula and stylet are then removed from the lumen of the graft vessel through its free end. - In another example of such an embodiment, the
anvil arm 14 is inserted into a hole in the wall of the target vessel and thestaple holder 38 deploys staples or other connectors to connect the graft vessel to the target vessel, as described above. Theanvil arm 14 is removed, and the hole in the wall of the target vessel is closed. Anindependent cutter 200 is then introduced through the wall of the graft vessel. Thecutter 200 itself may create an opening in the wall of the graft vessel through which it can enter, or a separate implement may be used to create an opening in the wall of the graft vessel. Thecutter 200 may be configured as described above, including aprojection 208 extending therefrom, or may be configured differently. For example, thecutter 200 may be J-shaped or L-shaped to facilitate creation of the opening between the graft vessel and the target vessel through the wall of the graft vessel. Thecutter 200 is manipulated relative to the connection between the target vessel and the graft vessel to create an opening in the wall of the target vessel at the junction therebetween. That is, registration is maintained between thecutter 200 and the junction between the end of the graft vessel and the wall of the target vessel. Thecutter 200 is then removed through the wall of the graft vessel, and the opening in the wall of the graft vessel is sealed. - While the invention has been described in detail, it will be apparent to one skilled in the art that various changes and modifications can be made and equivalents employed, without departing from the present invention. For example, the
tissue effector 400 may be connected directly to thehandle 302 without an interveningshaft 304, in a substantially rigid or substantially non-rigid manner. As another example, the mechanisms within thehandle 302 may be reversed or otherwise rearranged, while maintaining their ability to actuate thetissue effector 400. It is to be understood that the invention is not limited to the details of construction, the arrangements of components, and/or the process of performing anastomosis set forth in the above description or illustrated in the drawings. Further, the invention is not limited to the performance of anastomosis in the context of a CABG procedure, nor it is limited to the anastomosis of two bodily vessels. Other tissue structures than vessels may be connected together within the body utilizing the present invention. Therefore, the invention is not to be restricted or limited except in accordance with the following claims and their legal equivalents.
Claims (18)
1. A surgical stapler, comprising:
a staple holder;
a plurality of staples positioned within said staple holder; and
at least one structure slidable within said staple holder to contact directly at least one said staple, wherein said direct contact deploys said at least one said staple from said staple holder.
2. The surgical stapler of claim 1 , wherein said staple holder includes two arms spaced apart from one another; further comprising at least two staples, wherein each said arm holds at least one said staple.
3. The surgical stapler of claim 1 , further comprising a shaft connected to said staple holder, and a handle connected to said shaft; wherein said staple holder is orientable in a plurality of orientations relative to said shaft.
4. The surgical stapler of claim 1 , further comprising a shaft connected to said staple holder, and a handle connected to said shaft; wherein at least a portion of said shaft is flexible.
5. The surgical stapler of claim 1 , wherein at least a subset of said staples are arranged in a substantially linear row.
6. The surgical stapler of claim 1 , wherein said structure is a ramp element having a curved surface, wherein said curved surface directly contacts at least one said staple when said ramp element slides within said staple holder.
7. The surgical stapler of claim 1 , wherein said structure is slidable in a single motion to deploy a plurality of said staples.
8. The surgical stapler of claim 1 , further comprising a sled, wherein at least one said structure is a portion of said sled.
9. A surgical stapler, comprising:
a staple holder;
an anvil movably connected to said staple holder;
a plurality of staples positioned within said staple holder; and
a sled slidable within said staple holder to contact directly at least one said staple, wherein said direct contact urges at least one said staple out of said staple holder and against said anvil.
10. The surgical stapler of claim 9 , wherein said sled comprises at least one ramp element, wherein said sled contacts directly at least one said staple by direct contact between at least one said staple and at least one said ramp element.
11. The surgical stapler of claim 10 , wherein at least part of at least one said ramp element is curved.
12. The surgical stapler of claim 10 , wherein said sled includes at least two said ramp elements laterally spaced from one another.
13. The surgical stapler of claim 10 , wherein said sled includes at least two said ramp elements each having a longitudinal centerline, wherein said longitudinal centerlines are substantially parallel to one another.
14. The surgical stapler of claim 9 , wherein said sled is slidable in a single motion to urge a plurality of said staples out of said staple holder and against said anvil.
15. The surgical stapler of claim 9 , wherein said sled is slidable in a longitudinal direction.
16. The surgical stapler of claim 9 , wherein said sled is slidable distally to contact directly at least one said staple.
17. The surgical stapler of claim 9 , further comprising a shaft connected to said staple holder, and a handle connected to said shaft; wherein said staple holder is orientable in a plurality of orientations relative to said shaft.
18. The surgical stapler of claim 9 , further comprising a shaft connected to said staple holder, and a handle connected to said shaft; wherein at least a portion of said shaft is flexible.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/970,678 US20110101069A1 (en) | 1999-07-28 | 2010-12-16 | Surgical Stapler with Direct Sled to Staple Contact |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/363,255 US6391038B2 (en) | 1999-07-28 | 1999-07-28 | Anastomosis system and method for controlling a tissue site |
US10/151,441 US7285131B1 (en) | 1999-07-28 | 2002-05-20 | System for performing anastomosis |
US10/392,336 US7766924B1 (en) | 1999-07-28 | 2003-03-19 | System for performing anastomosis |
US11/378,127 US9622748B2 (en) | 1999-07-28 | 2006-03-17 | Anastomosis system with flexible shaft |
US12/970,678 US20110101069A1 (en) | 1999-07-28 | 2010-12-16 | Surgical Stapler with Direct Sled to Staple Contact |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/378,127 Continuation US9622748B2 (en) | 1999-07-28 | 2006-03-17 | Anastomosis system with flexible shaft |
Publications (1)
Publication Number | Publication Date |
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US20110101069A1 true US20110101069A1 (en) | 2011-05-05 |
Family
ID=34396925
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
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US10/988,326 Abandoned US20050154406A1 (en) | 1999-07-28 | 2004-11-12 | Method for anastomosing vessels |
US10/988,335 Expired - Lifetime US7303570B2 (en) | 1999-07-28 | 2004-11-12 | Anastomosis tool having a connector holder |
US11/378,127 Expired - Lifetime US9622748B2 (en) | 1999-07-28 | 2006-03-17 | Anastomosis system with flexible shaft |
US12/970,678 Abandoned US20110101069A1 (en) | 1999-07-28 | 2010-12-16 | Surgical Stapler with Direct Sled to Staple Contact |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
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US10/988,326 Abandoned US20050154406A1 (en) | 1999-07-28 | 2004-11-12 | Method for anastomosing vessels |
US10/988,335 Expired - Lifetime US7303570B2 (en) | 1999-07-28 | 2004-11-12 | Anastomosis tool having a connector holder |
US11/378,127 Expired - Lifetime US9622748B2 (en) | 1999-07-28 | 2006-03-17 | Anastomosis system with flexible shaft |
Country Status (1)
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US (4) | US20050154406A1 (en) |
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Also Published As
Publication number | Publication date |
---|---|
US20050154406A1 (en) | 2005-07-14 |
US20060241660A1 (en) | 2006-10-26 |
US9622748B2 (en) | 2017-04-18 |
US7303570B2 (en) | 2007-12-04 |
US20050131428A1 (en) | 2005-06-16 |
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