US20090299253A1 - Blood clotting compositions and wound dressings - Google Patents

Blood clotting compositions and wound dressings Download PDF

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US20090299253A1
US20090299253A1 US12510203 US51020309A US2009299253A1 US 20090299253 A1 US20090299253 A1 US 20090299253A1 US 12510203 US12510203 US 12510203 US 51020309 A US51020309 A US 51020309A US 2009299253 A1 US2009299253 A1 US 2009299253A1
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blood
zeolite
method
clay material
wound
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US12510203
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Francis X. Hursey
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Z-MEDICA LLC
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Hursey Francis X
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0004Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/04Materials for stopping bleeding

Abstract

In general, the basic material forming the wound dressing, covering, and/or application system of the present invention for use in blood coagulation comprises a combination of one or more components selected from the group consisting of clay materials, a molecular sieve material, principally zeolite, and inorganic oxide materials. Although the actual process which enables the wound dressing, covering, and/or application system of the present invention to effectively coagulate flowing blood is unknown, it is believed that the molecular sieve material selectively absorbs small molecules, such as water, from the blood. Due to the absorption of the water molecules, it is believed that the rate of blood clotting is increased.

Description

    CROSS REFERENCE TO RELATED APPLICATIONS
  • This application is a continuation of U.S. patent application Ser. No. 10/939,869, filed Sep. 13, 2004, which claims the benefit of U.S. Provisional Patent Application No. 60/502,571 filed Sep. 12, 2003, entitled “Blood Clotting Compositions and Wound Dressings,” to Francis X. Hursey, the contents of these priority documents are incorporated herein by reference.
  • TECHNICAL FIELD
  • The present invention relates to blood clotting devices (also referred to as hemostatic agents) and methods of controlling bleeding and, more particularly, to blood clotting materials and compositions for use as bleeding control devices.
  • BACKGROUND OF THE INVENTION
  • Blood is a liquid tissue that includes red cells, white cells, corpuscles, and platelets dispersed in a liquid phase. The liquid phase is plasma, which includes acids, lipids, solublized electrolytes, and proteins. The proteins are suspended in the liquid phase and can be separated out of the liquid phase by any of a variety of methods such as filtration, centrifugation, electrophoresis, and immunochemical techniques. One particular protein suspended in the liquid phase is fibrinogen. When bleeding occurs, the fibrinogen reacts with water and thrombin (an enzyme) to form fibrin, which is insoluble in blood and polymerizes to form clots.
  • In a wide variety of circumstances, animals, including humans, can be wounded. Often bleeding is associated with such wounds. In some instances, the wound and the bleeding are minor, and normal blood clotting functions in addition to the application of simple first aid are all that is required. Unfortunately, however, in other circumstances, substantial bleeding can occur. These situations usually require specialized equipment and materials as well as personnel trained to administer appropriate aid. If such aid is not readily available, excessive blood loss can occur. When bleeding is severe, sometimes the immediate availability of equipment and trained personnel is still insufficient to stanch the flow of blood in a timely manner.
  • Moreover, severe wounds can often be inflicted in very remote areas or in situations, such as on a battlefield, where adequate medical assistance is not immediately available. In these instances, it is important to stop bleeding, even in less severe wounds, long enough to allow the injured person or animal to receive medical attention.
  • In an effort to address the above-described problems, materials have been developed for controlling excessive bleeding in situations where conventional aid is unavailable or less than optimally effective. Although these materials have been shown to be somewhat successful, they are not effective enough for traumatic wounds and tend to be expensive. Furthermore, these materials are sometimes ineffective in all situations and can be difficult to apply as well as remove from a wound. Additionally, or alternatively, they can produce undesirable side effects.
  • Compositions for promoting the formation of clots in blood have also been developed. Such compositions generally comprise zeolites and binders. In a typical zeolite/binder composition, the water content is estimated to be about 1.54% or less. The water content is estimated by measuring the mass of material before and after heating at 550 degrees C. (Loss on Ignition (LOI) at 550 degrees C.). Higher temperatures are sometimes used for LOI calculations, but procedures that utilize these higher temperatures increase the loss of chemical compounds other than water.
  • Based on the foregoing, it is a general object of the present invention to provide a bleeding control device that overcomes or improves upon the prior art.
  • SUMMARY OF THE INVENTION
  • In general, the basic material forming the wound dressing, covering, and/or application system of the present invention for use in blood coagulation comprises a combination of one or more components selected from the group consisting of clay materials, a molecular sieve material, principally zeolite, and inorganic oxide materials. Although the actual process which enables the wound dressing, covering, and/or application system of the present invention to effectively coagulate flowing blood is unknown, it is believed that the molecular sieve material selectively absorbs small molecules, such as water, from the blood. Due to the absorption of the water molecules, it is believed that the rate of blood clotting is increased.
  • According to one aspect of the present invention, a composition for promoting the formation of clots in blood comprises a zeolite and a binder. In such a composition, the moisture content of the zeolite is adjusted by drying, re-hydrating, or a combination of drying and re-hydrating such that the zeolite has a specific moisture content. Alternatively, the composition may be fully saturated with water and subsequently dried to a specific water content. In the drying of the zeolite, the bound water is removed to allow the crystalline structure of the zeolite to remain intact. In the re-hydration of the zeolite, the most active adsorption sites are hydrated first and then less active sites are hydrated. As the zeolite's degree of hydration increases, the heat of hydration decreases. More specifically, when the composition is applied to the blood, water in the blood is adsorbed by the zeolite. Upon adsorption of this water, heat is generated. At higher levels of hydration (hydration of the zeolite prior to its application to blood), less heat is generated when the composition is applied to blood. Thus, when the composition is applied to blood directly at a wound site, the amount of heat transferred to the tissue surrounding the wound site is reduced.
  • According to another aspect of the present invention, a method of forming a blood-clotting composition comprises the steps of providing a zeolite in hydrated form and adjusting a moisture content of the zeolite to have a specific moisture content such that upon application of the composition to a wound, a heat of hydration is reduced and a heat transferred to the wound is reduced.
  • According to another aspect of the present invention, a method of clotting blood flowing from a wound comprises the steps of applying a zeolite to the wound and maintaining the zeolite in contact with the wound for a predetermined amount of time, the zeolite having an adjusted moisture content and being capable of producing a controllable exothermic effect on the wound.
  • One advantage of the present invention is that it is easily applied to an open wound. It can be readily removed from sterilized packaging and deposited directly at the points from which blood emanates to dress the wound.
  • Another advantage of the present invention is that the rate of water adsorption is dramatically reduced as the degree of hydration increases from about 0.1% to about 4%. After about 4%, the rate of adsorption is slower. Also, after about 4%, the rate of adsorption changes more slowly. In application of the composition to promote the clotting of blood, slower water adsorption is advantageous for two reasons. First, the humidity and temperature of the packaging environment has less of an affect, thereby allowing material to be exposed to the environment for a longer period of time without significantly changing the pre-hydration level. Second, the slower rate of water adsorption allows the heat of hydration to be dissipated over a longer period of time. Therefore, the composition is heated to a lower maximum temperature. Thus, less heat is transferred to the tissue of a wound without losing product efficacy (formation of clots in blood).
  • The present invention is able to effectively clot traumatic bleeding of wounds better than other available methods for treating similar wounds. For example, in a lethal femoral swine model in which several blood clotting materials were evaluated, the material of the present invention was the only material proven to have a morbidity rate of 0% including a standard pressure dressing.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • By employing the present invention, all of the difficulties and drawbacks found in the prior art have been eliminated, and a highly effective, reasonably priced, easily used wound dressing, covering, and/or application system is realized. In accordance with the present invention, the wound dressing, covering, and/or application system generally comprises, in its principal basic form, a unique composition or formulation which is easily applied to an open wound and rapidly and effectively promotes the clotting rate of any flowing blood. In this way, blood emanating from the open wound coagulates or clots in a rapid or accelerated manner.
  • In its principal form, the wound dressing, coverings, and/or application system of the present invention comprises a molecular sieve material, which preferably consists of zeolite, in combination with a suitable binder in a sterilized form enabling its application directly to an open wound. Although the wound treatment material may be applied directly to the open wound, as the sole component for inducing blood coagulation, it is preferable that the wound or opening is also treated with sterilized dressings, such as gauze, pads, multiple layer covers, films, permeable bandages, and the like. In this way, the rate of blood clotting is increased and the rate of blood loss from the wound is rapidly reduced.
  • In general, the basic material forming the wound dressing, covering, and/or application system of the present invention for use in blood coagulation comprises a combination of one or more components selected from the group consisting of clay materials, a molecular sieve material, principally zeolite, and inorganic oxide materials. Although the actual process which enables the wound dressing, covering, and/or application system of the present invention to effectively coagulate flowing blood is unknown, it is believed that the molecular sieve material selectively absorbs small molecules, such as water, from the blood. Due to the absorption of the water molecules, it is believed that the rate of blood clotting is increased.
  • In addition, other factors such as the production of heat and the presence of Ca ions in the inorganic oxide materials are believed to contribute to the efficacy of the compositions of the present invention in providing the desired rapid stoppage wound bleeding and promotion of blood coagulation. Although the precise mechanism or process by which the compositions of the present invention provided the desired results, it has been found that the compositions detailed herein provide a highly effective blood coagulation product capable of being quickly and easily applied to any desired wound site for achieving rapid termination of blood flow.
  • In this regard, the present invention is capable of being employed in a wide variety of applications and/or uses. One principal use is in trauma situations, such as car accidents, where large open wounds may be produced with excessive blood loss. In addition, similar conditions are often found in military applications, particularly during armed conflicts. Furthermore, numerous other applications benefit from the use of the present invention, such as use in a surgical environment as well as in veterinary applications where animal bleeding occurs due to accidents or surgical operations.
  • In order to provide the desired water absorption capabilities, the molecular sieve material or zeolite forming a part of the composition of this invention is typically dehydrated in its final form, usually to a hydration level of about 0.5%. In addition, the application of the dehydrated zeolite material to the open wound produces an exothermic reaction, which often assists with the promotion of the coagulation of the blood. However, in some instances, the exothermic reaction is substantial, causing damage to the surrounding tissue.
  • In order to eliminate any potential harm being caused to surrounding tissue, as well assuring the creation of a wound dressing, covering, and/or application system which achieves all of the desired goals, it has been found that the efficacy provided by the molecular sieve material/zeolite is enhanced by rehydrating the molecular sieve material/zeolite to a hydration level ranging between about 1% and 15%. In addition, it has been found that this hydration level more preferably ranges between about 2% and 8%.
  • By rehydrating the molecular sieve material/zeolite to a level ranging between about 1% and 15%, it has been found that the exothermia cause by the reaction of the molecular sieve material/zeolite with the blood flowing from an open wound is reduced to a level which virtually eliminates any potential damage to the surrounding tissue. In addition, the rate of blood coagulation is substantially unaffected, continuing to provide the desired rapid stoppage of blood flow by clotting the blood and effectively cauterizing the wound area.
  • Disclosed herein are compositions and methods directed to the clotting of blood and the forming of blood clotting compositions. The compositions generally include molecular sieves for minimizing or stopping bleeding by absorbing at least portions of the liquid phases of blood, thereby promoting clotting. The methods generally include the application of molecular sieves to bleeding wounds to provide dressings and removing components of the blood to facilitate the formation of clots.
  • In one embodiment of the present invention, a molecular sieve comprises a zeolite and a binder. As used herein, the term “zeolite” refers to a crystalline form of aluminosilicate that may include several ionic species including sodium and calcium moieties. The preferred molecular structure of the zeolite is referred to as an “A-type” crystal. As used herein, the term “A-type crystal” is intended to indicate a crystal having a cubic crystalline structure and round holes. The zeolite may be ion-exchanged to include a specific cation, for example, calcium, sodium, potassium, silver, or magnesium, or any combination of the foregoing. Suitable zeolites for use in the applications disclosed herein are also preferably nanoporous so as to provide increased surface areas. As used herein, the term “nanoporous” is intended to indicate an average pore diameter of about 3 angstroms to about 5 angstroms.
  • In another embodiment of the present invention, the zeolite comprises irregularly-shaped granular material that is prepared by grinding larger particles and then selecting material that will pass through a 16 mesh sieve screen but will not pass through a 40 mesh sieve screen. The resulting zeolite is a composition of irregular granules that range in size from 0.4 millimeters (mm) in diameter to 0.8 mm in diameter.
  • Zeolites for use in the disclosed applications may be naturally occurring or synthetically produced. Numerous varieties of naturally occurring zeolites are found as deposits in sedimentary environments as well as in other places. Naturally occurring zeolites that may be applicable to the compositions and methods described herein include, but are not limited to, analcite, chabazite, heulandite, natrolite, stilbite, and thomosonite. Synthetically produced zeolites that may also find use in the compositions and methods described herein are generally produced by processes in which rare earth oxides are substituted by silicates, alumina, or alumina in combination with alkali or alkaline earth metal oxides.
  • The binder is preferably clay-based and may further include fillers (e.g., aluminum sulfate) or thickening agents that facilitate the selective application of the zeolite in various forms (e.g., as a paste, gel, powder, or erodible solid member). Natural clays that may provide suitable bases include, but are not limited to, kaolin, kaolinite, bentonite, montmorillonite, combinations of the foregoing clays, and the like. Modified clays such as polyorganosilcate graft polymers may also provide suitable bases.
  • In the preparation of the zeolite for a blood clotting composition, the moisture content of the zeolite is adjusted by drying, re-hydrating, or a combination of drying and re-hydrating the zeolite such that the zeolite has a specific moisture content. A fully hydrated zeolite has a moisture content of about 20 weight percent (wt. %). Drying of the zeolite may be effected by the application of heat. Upon heating, adsorbed water bound in the crystalline structure is driven off without altering the structure itself or detracting from its integrity. The dried zeolite may then be re-hydrated. Upon drying or drying and re-hydrating, the zeolite contains about 1.55 wt. % to about 10 wt. % moisture, and preferably about 1.55 wt. % to about 4 wt. % moisture. Alternatively, the drying process can be stopped before the material is completely dehydrated. The final hydration of the material can be controlled by monitoring and controlling the temperature of zones of a drying apparatus in which the material is dried.
  • The hydrated zeolite material also generates less heat upon being fully-saturated with water in the application of the zeolite to the blood. In particular, the heat of hydration is inversely proportional to the moisture content. Therefore, a zeolite hydrated to a moisture content of 4 wt. % will generate measurably less heat than a zeolite that has been fully dehydrated to less than 0.1 wt. %. Both materials, however, will be fully-saturated with water upon application to a bleeding wound. Thus, when applied to a bleeding wound under conditions of actual use, the exothermic effects and heat transferred to the wound are reduced. Therefore, upon application of the composition of the present invention to a bleeding wound, less heat is transferred to the tissue of the wound.
  • As stated above, upon treating wounds with the present invention, the remaining blood, which includes cells, corpuscles, platelets, and plasma, is concentrated. The platelets aggregate and interact with collagen, phospholipids, and lipid-containing proteins in the plasma. The aggregation of the platelets provide nuclei upon which fibrin binds to form a clot. Cells from the blood subsequently combine with the clot to form a mass. When blood emanates from the wound, the formation of the mass from the clot causes the flow of blood to cease, thereby eliminating further loss of blood. The blood pressure will often noticeably increase upon application of the present invention due to cessation of blood loss.
  • EXAMPLE 1 Comparison of Supernatant Phase of Zeolite-Reacted Plasma With Serum
  • A molecular sieve containing partially re-hydrated zeolite was added to normal pooled plasma. Upon completion of the ensuing reaction, the plasma was separated into two phases, namely, a heavy phase and a supernatant phase. The heavy phase included the typical blood plasma components as well as the reacted zeolite. The supernatant phase was tested to determine the levels of PT, aPTT, and fibrinogen, where “PT” is prothrombin time and “aPTT” is activated partial thromboplastin time. As used herein, PT and aPPT are assays that provide time values that are compared to other samples or to a hemotological standard. The time values are used indirectly to suggest the levels of clotting factors present in pooled plasma. A control comprising serum was also tested to determine the levels of the same components. In a comparison of the supernatant phase to the control, it was noted that the PT, aPTT, and fibrinogen levels were comparable, thereby suggesting that factors indicative of the clotting of blood were depleted by the addition of the molecular sieve containing partially re-hydrated zeolite.
  • EXAMPLE 2 Determination of Exothermic Effect of Zeolite-Reacted Plasma
  • Varying amounts of a molecular sieve containing zeolite were added to 1 milliliter (ml) samples of normal pooled plasma. In the first sample, 200 milligram (mg) of the molecular sieve was added and reacted, and a temperature increase of 9 centigrade (C.) degrees was observed. In the second sample, about 3.8 mg of the molecular sieve was added and reacted, and a temperature increase of less than 1 C. degree was observed.
  • Although this invention has been shown and described with respect to the detailed embodiments thereof, it will be understood by those of skill in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In addition, modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiments disclosed in the above detailed description, but that the invention will include all embodiments falling within the scope of the appended claims.

Claims (14)

  1. 1. A method for promoting blood coagulation comprising: applying a wound dressing, covering, or application system to a bleeding area, wherein the wound dressing, covering, or application system comprises:
    a clay material; and
    a gauze pad, a multiple layer cover, or a permeable bandage.
  2. 2. The method of claim 1, wherein the clay material comprises kaolin or kaolinite.
  3. 3. The method of claim 1, wherein the clay material consists essentially of kaolin or kaolinite.
  4. 4. The method of claim 1, wherein the clay material comprises bentonite.
  5. 5. The method of claim 1, wherein the clay material consists essentially of bentonite.
  6. 6. The method of claim 1, wherein the clay material comprises montmorillonite.
  7. 7. The method of claim 1, wherein the clay material consists essentially of montmorillonite.
  8. 8. A method for promoting blood coagulation comprising:
    applying a clay material to a bleeding area; and
    applying a gauze pad, a multiple layer cover, or a permeable bandage to a bleeding area.
  9. 9. The method of claim 8, wherein the clay material comprises kaolin or kaolinite.
  10. 10. The method of claim 8, wherein the clay material consists essentially of kaolin or kaolinite.
  11. 11. The method of claim 8, wherein the clay material comprises bentonite.
  12. 12. The method of claim 8, wherein the clay material consists essentially of bentonite.
  13. 13. The method of claim 8, wherein the clay material comprises montmorillonite.
  14. 14. The method of claim 8, wherein the clay material consists essentially of montmorillonite.
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US10939869 US8252344B2 (en) 2003-09-12 2004-09-13 Partially hydrated hemostatic agent
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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968114B2 (en) 2006-05-26 2011-06-28 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US8066874B2 (en) 2006-12-28 2011-11-29 Molycorp Minerals, Llc Apparatus for treating a flow of an aqueous solution containing arsenic
US8114433B2 (en) 2006-05-26 2012-02-14 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
CN102366640A (en) * 2011-10-14 2012-03-07 浙江安吉华埠实业有限公司 Zeolite tourniquet bandage
US8202532B2 (en) 2006-05-26 2012-06-19 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US8252344B2 (en) 2003-09-12 2012-08-28 Z-Medica Corporation Partially hydrated hemostatic agent
US8252087B2 (en) 2007-10-31 2012-08-28 Molycorp Minerals, Llc Process and apparatus for treating a gas containing a contaminant
US8257731B2 (en) 2005-02-09 2012-09-04 Z-Medica Corporation Devices and methods for the delivery of molecular sieve materials for the formation of blood clots
US8349764B2 (en) 2007-10-31 2013-01-08 Molycorp Minerals, Llc Composition for treating a fluid
WO2013040080A1 (en) * 2011-09-12 2013-03-21 Protege Biomedical, Llc Composition and dressing for wound treatment
US8475658B2 (en) 2003-01-29 2013-07-02 Molycorp Minerals, Llc Water purification device for arsenic removal
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
US8938898B2 (en) 2006-04-27 2015-01-27 Z-Medica, Llc Devices for the identification of medical products
US9072806B2 (en) 2012-06-22 2015-07-07 Z-Medica, Llc Hemostatic devices
US9233863B2 (en) 2011-04-13 2016-01-12 Molycorp Minerals, Llc Rare earth removal of hydrated and hydroxyl species
US9975787B2 (en) 2014-03-07 2018-05-22 Secure Natural Resources Llc Removal of arsenic from aqueous streams with cerium (IV) oxide compositions

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1663090A4 (en) * 2003-09-12 2010-07-21 Z Medica Corp Calcium zeolite hemostatic agent
US8916208B2 (en) * 2004-06-24 2014-12-23 California Institute Of Technology Aluminophosphate-based materials for the treatment of wounds
CN101160143A (en) 2005-02-15 2008-04-09 弗吉尼亚大学 Mineral technologies (mt) for acute hemostasis and for the treatment of acute wounds and chronic ulcers
US20060211965A1 (en) * 2005-03-16 2006-09-21 Z-Medica, Llc Device for the delivery of blood clotting materials to a wound site
US9326995B2 (en) * 2005-04-04 2016-05-03 The Regents Of The University Of California Oxides for wound healing and body repair
US20060282046A1 (en) * 2005-04-13 2006-12-14 Horn Jeffrey L Device and method for subcutaneous delivery of blood clotting agent
JP2007144154A (en) * 2005-11-07 2007-06-14 Jeffrey L Horn Devices for delivery of molecular sieve materials for formation of blood clots
US20070104768A1 (en) * 2005-11-07 2007-05-10 Z-Medica Corporation Devices for the delivery of molecular sieve materials for the formation of blood clots
US20070154510A1 (en) * 2005-12-30 2007-07-05 Wilcher Steve A Adsorbent-Containing Hemostatic Devices
US20070154509A1 (en) * 2005-12-30 2007-07-05 Wilcher Steve A Adsorbent-Containing Hemostatic Devices
DE102006006905A1 (en) * 2006-02-09 2007-08-23 Durtec Gmbh Means for hemostasis
DE102006006904A1 (en) * 2006-02-09 2007-08-23 Ernst-Moritz-Arndt Universität Greifswald New means of hemostasis and adhesives for medical applications
US20070276308A1 (en) * 2006-05-26 2007-11-29 Huey Raymond J Hemostatic agents and devices for the delivery thereof
US20080063697A1 (en) * 2006-09-08 2008-03-13 Bedard Robert L Use of Unactivated Calcium Exchanged Zeolites in Hemostatic Devices and Products
US20080125686A1 (en) * 2006-11-29 2008-05-29 Denny Lo Heat mitigating hemostatic agent
US20080145455A1 (en) * 2006-12-13 2008-06-19 Bedard Robert L Combination of Inorganic Hemostatic Agents with Other Hemostatic Agents
US8703634B2 (en) * 2007-02-21 2014-04-22 The Regents Of The University Of California Hemostatic compositions and methods of use
US20080317831A1 (en) * 2007-06-21 2008-12-25 Denny Lo Hemostatic sponge and method of making the same
US8202549B2 (en) 2007-08-14 2012-06-19 The Regents Of The University Of California Mesocellular oxide foams as hemostatic compositions and methods of use
US20090047366A1 (en) * 2007-08-15 2009-02-19 Bedard Robert L Inorganic Coagulation Accelerators for Individuals taking Platelet Blockers or Anticoagulants
US20090162406A1 (en) * 2007-09-05 2009-06-25 Z-Medica Corporation Wound healing with zeolite-based hemostatic devices
US8883194B2 (en) * 2007-11-09 2014-11-11 Honeywell International, Inc. Adsorbent-containing hemostatic devices
US8795718B2 (en) * 2008-05-22 2014-08-05 Honeywell International, Inc. Functional nano-layered hemostatic material/device
WO2011066471A1 (en) 2009-11-25 2011-06-03 Loma Linda University Medical Center Chitosan-based hemostatic textile
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US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications

Citations (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2969145A (en) * 1956-05-07 1961-01-24 Johnson & Johnson Packaged adhesive bandage
US3122140A (en) * 1962-03-29 1964-02-25 Johnson & Johnson Flexible absorbent sheet
US3181231A (en) * 1963-08-06 1965-05-04 Union Carbide Corp Molecular sieve-metal agglomerates and their preparation
US3189227A (en) * 1962-12-07 1965-06-15 American Home Prod Fluid dispenser
US3366578A (en) * 1964-12-07 1968-01-30 Universal Oil Prod Co Zeolite and method for making the improved zeolite
US3386802A (en) * 1967-07-28 1968-06-04 Universal Oil Prod Co Method for preparing spherically-shaped crystalline zeolite particles
US3698392A (en) * 1971-04-21 1972-10-17 Kewanee Oil Co Topical dressing
US3723352A (en) * 1971-01-25 1973-03-27 Air Prod & Chem Supported silver catalysts
US4373519A (en) * 1981-06-26 1983-02-15 Minnesota Mining And Manufacturing Company Composite wound dressing
US4374044A (en) * 1981-01-19 1983-02-15 General Motors Corporation Cordierite bead catalyst support and method of preparation
US4379143A (en) * 1980-12-05 1983-04-05 Pq Corporation Topical liquid or ointment
US4435512A (en) * 1980-11-28 1984-03-06 Nippondenso Co., Ltd. Process for producing cordierite ceramic products
US4460642A (en) * 1981-06-26 1984-07-17 Minnesota Mining And Manufacturing Company Water-swellable composite sheet of microfibers of PTFE and hydrophilic absorptive particles
US4514510A (en) * 1983-09-08 1985-04-30 American Colloid Company Hydrogen enriched water swellable clay having reduced acid demand and stable at low pH
US4524064A (en) * 1982-05-26 1985-06-18 Nippon Oil Company, Limited Wound-covering materials
US4525410A (en) * 1982-08-24 1985-06-25 Kanebo, Ltd. Particle-packed fiber article having antibacterial property
US4569343A (en) * 1982-09-30 1986-02-11 Firma Carl Freudenberg Skin application medicament
US4651725A (en) * 1985-04-18 1987-03-24 Unitika Ltd. Wound dressing
US4717735A (en) * 1986-04-10 1988-01-05 European Body Wrap, Inc. Composition for body wrap
US4728323A (en) * 1986-07-24 1988-03-01 Minnesota Mining And Manufacturing Company Antimicrobial wound dressings
US4748978A (en) * 1984-09-27 1988-06-07 Kamp Herman F Therapeutic dressing having mineral components
US4822349A (en) * 1984-04-25 1989-04-18 Hursey Francis X Method of treating wounds
US4828832A (en) * 1983-09-07 1989-05-09 Laboratorios Biochemie De Mexico Method of manufacturing a composition for treating skin lesions
US4828081A (en) * 1988-03-04 1989-05-09 Samsonite Corporation Luggage identification system
US4911898A (en) * 1983-01-21 1990-03-27 Kanebo Limited Zeolite particles retaining silver ions having antibacterial properties
US5486195A (en) * 1993-07-26 1996-01-23 Myers; Gene Method and apparatus for arteriotomy closure
US5502042A (en) * 1994-07-22 1996-03-26 United States Surgical Corporation Methods and compositions for treating wounds
US5597581A (en) * 1993-07-09 1997-01-28 Karl W. An Haak Chitosan foil for wound sealing and process for its preparation
US5599578A (en) * 1986-04-30 1997-02-04 Butland; Charles L. Technique for labeling an object for its identification and/or verification
US5716337A (en) * 1992-06-10 1998-02-10 Johnson & Johnson Medical, Inc. Absorbent product
US5725551A (en) * 1993-07-26 1998-03-10 Myers; Gene Method and apparatus for arteriotomy closure
US5728451A (en) * 1994-11-28 1998-03-17 Langley; John D. Breathable non-woven composite viral penetration barrier fabric and fabrication process
US5766715A (en) * 1995-04-10 1998-06-16 Michel Garçonnet Compact disposable packing that forms a kit
US5801116A (en) * 1995-04-07 1998-09-01 Rhodia Inc. Process for producing polysaccharides and their use as absorbent materials
US5855570A (en) * 1995-04-12 1999-01-05 Scherson; Daniel A. Oxygen producing bandage
US5916511A (en) * 1997-08-19 1999-06-29 Ngk Insulators, Ltd. Production method of cordierite ceramic honeycomb structure
US6037280A (en) * 1997-03-21 2000-03-14 Koala Konnection Ultraviolet ray (UV) blocking textile containing particles
US6060461A (en) * 1999-02-08 2000-05-09 Drake; James Franklin Topically applied clotting material
US6187347B1 (en) * 2000-02-09 2001-02-13 Ecosafe, Llc. Composition for arresting the flow of blood and method
US6203512B1 (en) * 1999-06-28 2001-03-20 The Procter & Gamble Company Method for opening a packaging device and retrieving an interlabial absorbent article placed therein
US6251423B1 (en) * 1995-05-20 2001-06-26 Smith & Nephew Plc Sterilizable paste product for topical application
US6372333B1 (en) * 1998-02-25 2002-04-16 Rengo Co., Ltd. Composition containing inorganic porous crystals-hydrophilic macromolecule composite and product made therefrom
US20020077653A1 (en) * 1998-04-08 2002-06-20 Hudson John Overton Hemostatic system for body cavities
US20030018357A1 (en) * 2001-05-09 2003-01-23 Luthra Ajay K. Wound closure system and methods
US6523778B2 (en) * 2000-06-29 2003-02-25 The Night Fun Co., Llc Illuminated emergency signaling device and flying balloon
US6573419B2 (en) * 2000-08-25 2003-06-03 Sody Naimer Elastic adhesive wound dressing for control of bleeding and for dressing bleeding wounds
US20040005350A1 (en) * 2002-06-28 2004-01-08 Looney Dwayne Lee Hemostatic wound dressings and methods of making same
US6685227B2 (en) * 2000-07-14 2004-02-03 Safer Sleep Limited Label, a label system and method
US20040038893A1 (en) * 2002-06-07 2004-02-26 Dyax Corp. Prevention and reduction of blood loss
US6700032B1 (en) * 1996-03-07 2004-03-02 Leatherite Pty Limited Wound care management
US6701649B1 (en) * 2002-12-12 2004-03-09 Gunter Brosi Combat identification marker
US6745720B2 (en) * 2002-10-29 2004-06-08 Cycle Group Limited Of Delaware Clumping animal litter and method of making same
US20040121438A1 (en) * 2002-12-19 2004-06-24 Stephen Quirk Wound care compositions
US20050023956A1 (en) * 2003-07-29 2005-02-03 Samsung Sdi Co., Ltd. Flat panel display
US20050058721A1 (en) * 2003-09-12 2005-03-17 Hursey Francis X. Partially hydrated hemostatic agent
US20050070693A1 (en) * 2003-07-31 2005-03-31 Immunomedics, Inc. Therapy using anti-CD-19 antibodies
US20050074505A1 (en) * 2003-09-12 2005-04-07 Hursey Francis X. Calcium zeolite hemostatic agent
US6890177B2 (en) * 2002-12-02 2005-05-10 Centrix, Inc. Method and device for the retraction and hemostasis of tissue during crown and bridge procedures
US20050107826A1 (en) * 2003-08-14 2005-05-19 Zhu Yong H. Vascular wound closure device and method
US20050118230A1 (en) * 2003-10-22 2005-06-02 Encelle, Inc. Methods and compositions for regenerating connective tissue
US20050119112A1 (en) * 2002-01-22 2005-06-02 Zeochem, Llc Process for production of molecular sieve adsorbent blends
US20050137512A1 (en) * 2003-12-23 2005-06-23 Campbell Todd D. Wound dressing and method for controlling severe, life-threatening bleeding
US20050143689A1 (en) * 2003-08-17 2005-06-30 Ramsey Maynard Iii Internal compression tourniquet catheter system and method for wound track navigation and hemorrhage control
US6998510B2 (en) * 2002-02-04 2006-02-14 Damage Control Surgical Technologies, Inc. Method and apparatus for improved hemostasis and damage control operations
US20060034935A1 (en) * 2004-07-22 2006-02-16 Pronovost Allan D Compositions and methods for treating excessive bleeding
US20060078628A1 (en) * 2004-10-09 2006-04-13 Karl Koman Wound treating agent
US20060116635A1 (en) * 2004-11-29 2006-06-01 Med Enclosure L.L.C. Arterial closure device
US20060121101A1 (en) * 2004-12-08 2006-06-08 Ladizinsky Daniel A Method for oxygen treatment of intact skin
US20060141060A1 (en) * 2004-12-27 2006-06-29 Z-Medica, Llc Molecular sieve materials having increased particle size for the formation of blood clots
US20060141018A1 (en) * 2001-12-31 2006-06-29 Crosslink-D, Incorporated, A Delaware Corporation Hemostatic compositions and methods for controlling bleeding
US20070016152A1 (en) * 2005-07-14 2007-01-18 Boehringer Laboratories, Inc. System for treating a wound with suction and method detecting loss of suction
US20070031515A1 (en) * 2005-04-04 2007-02-08 Stucky Galen D Inorganic materials for hemostatic modulation and therapeutic wound healing
US20070065491A1 (en) * 2005-02-09 2007-03-22 Z-Medica Corporation Devices and methods for the delivery of blood clotting materials to bleeding wounds
US20070104792A1 (en) * 2005-09-13 2007-05-10 Elan Pharma International, Limited Nanoparticulate tadalafil formulations
US20070104768A1 (en) * 2005-11-07 2007-05-10 Z-Medica Corporation Devices for the delivery of molecular sieve materials for the formation of blood clots
US20070276345A1 (en) * 2006-05-26 2007-11-29 Raymond Huey Clay-based hemostatic agents and devices for the delivery thereof
US20080027365A1 (en) * 2006-06-01 2008-01-31 Huey Raymond J Hemostatic device with oxidized cellulose pad
US20080085300A1 (en) * 2006-10-06 2008-04-10 Z-Medica Corporation Hemostatic compositions and method of manufacture
US20080097271A1 (en) * 2006-10-20 2008-04-24 Z-Medica Corporation Devices and methods for the delivery of hemostatic agents to bleeding wounds
US7371403B2 (en) * 2002-06-14 2008-05-13 Providence Health System-Oregon Wound dressing and method for controlling severe, life-threatening bleeding
US20080125686A1 (en) * 2006-11-29 2008-05-29 Denny Lo Heat mitigating hemostatic agent
US20090008261A1 (en) * 2005-03-03 2009-01-08 Cambridge Enterprise Limited Oxygen Generation Apparatus and Method
US20090018479A1 (en) * 2002-06-14 2009-01-15 Hemcon Medical Technologies, Inc. Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chistosan
US20090043268A1 (en) * 2007-08-06 2009-02-12 Eddy Patrick E Wound treatment system and suction regulator for use therewith
US20090047366A1 (en) * 2007-08-15 2009-02-19 Bedard Robert L Inorganic Coagulation Accelerators for Individuals taking Platelet Blockers or Anticoagulants
US20090053288A1 (en) * 2007-08-20 2009-02-26 Eskridge Jr E Stan Hemostatic woven fabric
US20090076475A1 (en) * 2005-11-09 2009-03-19 Oxysure Systems Inc. Method and apparatus for delivering therapeutic oxygen treatments
US20090112170A1 (en) * 2007-10-26 2009-04-30 Electrochemical Oxygen Concepts, Inc Apparatus and methods for controlling tissue oxygenation for wound healing and promoting tissue viability
US20090123525A1 (en) * 2007-11-09 2009-05-14 Bedard Robert L Adsorbent-Containing Hemostatic Devices
US20100035045A1 (en) * 2008-01-21 2010-02-11 Imerys Pigments, Inc. Fibers comprising at least one filler and processes for their production
US20110015565A1 (en) * 2009-07-15 2011-01-20 Hursey Francis X Gas dispenser with therapeutic agent
US20110059287A1 (en) * 2008-01-21 2011-03-10 Imerys Pigments, Inc. Fibers comprising at least one filler, processes for their production, and uses thereof
US20110064785A1 (en) * 2007-12-06 2011-03-17 Nanosys, Inc. Nanostructure-Enhanced Platelet Binding and Hemostatic Structures
US20120004636A1 (en) * 2010-07-02 2012-01-05 Denny Lo Hemostatic fibrous material
US20120070470A1 (en) * 2010-09-22 2012-03-22 Z-Medica Corporation Hemostatic compositions, devices, and methods
US8383148B2 (en) * 2006-05-26 2013-02-26 Z-Medica, Llc Clay-based hemostatic agents and devices for the delivery thereof

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688586A (en) 1950-03-17 1954-09-07 Johnson & Johnson Improved hemostatic alginic surgical dressings and method of making
US3550593A (en) 1967-02-02 1970-12-29 Jack W Kaufman Therapeutic apparatus
US3538508A (en) 1968-08-08 1970-11-10 Samuel Young Combination pillow and crash helmet
US3979335A (en) * 1974-12-27 1976-09-07 Georgy Anatolievich Golovko Process for the preparation of synthetic zeolites
US4626550A (en) * 1985-01-14 1986-12-02 Pq Corporation Zeolite for personal care products
US4631845A (en) 1985-05-17 1986-12-30 Intermec Corporation Luggage tag
US4938958A (en) 1986-12-05 1990-07-03 Shinagawa Fuel Co., Ltd. Antibiotic zeolite
JPH0618899B2 (en) 1987-06-30 1994-03-16 品川燃料株式会社 Antibacterial zeolite-containing film
JPH0567282B2 (en) 1988-08-03 1993-09-24 Terumo Corp
US4956350A (en) 1988-08-18 1990-09-11 Minnesota Mining And Manufacturing Company Wound filling compositions
US5140949A (en) * 1989-09-19 1992-08-25 Mobil Oil Corporation Zeolite-clay composition and uses thereof
JP2777279B2 (en) 1990-10-08 1998-07-16 リンテック株式会社 Wound dressing and a method of manufacturing the same
US5146932A (en) 1990-11-01 1992-09-15 Mccabe Francis J Elastic counterpressure garment
GB9117998D0 (en) 1991-08-21 1991-10-09 Williams Glanmor T Odour adsorbing means
US5474545A (en) 1992-12-07 1995-12-12 Chikazawa; Osamu Diaper and/or sanitary napkin
GB9317180D0 (en) * 1993-08-18 1993-10-06 Unilever Plc Granular detergent compositions containing zeolite and process for their preparation
CA2176969A1 (en) 1994-09-19 1996-03-28 Hironobu Isogawa A blood component deposition-preventing agent, a blood coagulation accelerator, methods using them, and blood test ware and matrixes
JPH0877746A (en) 1994-08-31 1996-03-22 Sony Corp Recording medium housing cassette and cassette keeping case and label adhered thereto
US5826543A (en) 1995-01-20 1998-10-27 Ralston Purina Company Clumpable animal litter containing a dust reducing agent
US5538500A (en) 1995-02-08 1996-07-23 Peterson; Donald A. Postoperative wound dressing
US5788682A (en) 1995-04-28 1998-08-04 Maget; Henri J.R. Apparatus and method for controlling oxygen concentration in the vicinity of a wound
GB9520160D0 (en) 1995-10-03 1995-12-06 British Nuclear Fuels Plc An energy storage and conversion apparatus
US5696101A (en) 1996-04-16 1997-12-09 Eastman Chemical Company Oxidized cellulose and vitamin E blend for topical hemostatic applications
US5964239A (en) 1996-05-23 1999-10-12 Hewlett-Packard Company Housing assembly for micromachined fluid handling structure
GB2314842B (en) 1996-06-28 2001-01-17 Johnson & Johnson Medical Collagen-oxidized regenerated cellulose complexes
DE69729412T2 (en) 1996-08-27 2005-06-16 Rengo Co., Ltd. The composite material of a hydrophilic macromolecular substrate and inorganic porous crystals
US5834008A (en) 1996-09-19 1998-11-10 U.S. Biomaterials Corp. Composition and method for acceleration of wound and burn healing
JPH10298824A (en) 1997-04-22 1998-11-10 Chisso Corp Fiber and fibrous formed product using the same
US5941897A (en) 1997-05-09 1999-08-24 Myers; Gene E. Energy activated fibrin plug
GB2326827B (en) 1997-06-30 2002-02-20 Johnson & Johnson Medical Use of molecular sieves to promote wound healing
US6159232A (en) 1997-12-16 2000-12-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
WO1999045777A1 (en) 1998-03-10 1999-09-16 The Children's Hospital Of Philadelphia Compositions and methods for treatment of asthma
US6086970A (en) 1998-04-28 2000-07-11 Scimed Life Systems, Inc. Lubricious surface extruded tubular members for medical devices
US6123925A (en) 1998-07-27 2000-09-26 Healthshield Technologies L.L.C. Antibiotic toothpaste
WO2000018364A1 (en) 1998-09-25 2000-04-06 Kao Corporation Compositions for oral cavity
US20020197302A1 (en) 1998-11-12 2002-12-26 Cochrum Kent C. Hemostatic polymer useful for rapid blood coagulation and hemostasis
JP3423261B2 (en) 1999-09-29 2003-07-07 三洋電機株式会社 Display device
US6763373B2 (en) 1999-10-13 2004-07-13 Datahouse Labs, Inc. Method and system for creating and sending handwritten or handdrawn messages
US20040166172A1 (en) 2001-03-27 2004-08-26 Coni Rosati Bioctive tissue abrasives
US6450537B2 (en) 2000-01-24 2002-09-17 Polaroid Corporation Self-service postage stamp assemblage
KR100721752B1 (en) 2000-01-24 2007-05-25 쿠라레 메디카루 가부시키가이샤 Water-swellable polymer gel and process for preparing the same
EP1276463B1 (en) * 2000-04-28 2010-12-15 Biolife, L.L.C. Hemostatic agent, method and carrier for applying a blood clotting agent
US6592888B1 (en) 2000-05-31 2003-07-15 Jentec, Inc. Composition for wound dressings safely using metallic compounds to produce anti-microbial properties
US8524973B2 (en) 2000-09-15 2013-09-03 Bruder Healthcare Company Wound and therapy compress and dressing
WO2002030479A1 (en) * 2000-10-13 2002-04-18 On Site Gas Systems, Inc. Bandage using molecular sieves
EP1359876B1 (en) 2001-01-31 2005-12-14 Missak Kechichian Absorbent product
JP2004525921A (en) 2001-03-19 2004-08-26 イオマイ コーポレイシヨン Patch for transcutaneous immunization
US6481134B1 (en) 2001-04-02 2002-11-19 Alicia Aledo Tag for attaching to a garment having an attribute and identifying the attribute to a person unable to visually identify the attribute
US6622856B2 (en) 2001-04-25 2003-09-23 Johnson & Johnson Consumer Companies, Inc. Relief kit
US7429252B2 (en) 2001-12-12 2008-09-30 Ogenix Corporation Oxygen producing device for woundcare
US20030175333A1 (en) 2002-03-06 2003-09-18 Adi Shefer Invisible patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients onto the skin
US20030199922A1 (en) 2002-04-22 2003-10-23 Buckman James S. Pneumatic pressure bandage for medical applications
US20030212357A1 (en) 2002-05-10 2003-11-13 Pace Edgar Alan Method and apparatus for treating wounds with oxygen and reduced pressure
US20060193905A1 (en) 2002-05-14 2006-08-31 University Of Louisville Research Foundation, Inc. Direct cellular energy delivery system
GB0221688D0 (en) 2002-09-18 2002-10-30 Johnson & Johnson Medical Ltd Compositions for wound treatment
JP3794365B2 (en) 2002-10-04 2006-07-05 憲司 中村 Warm deodorant sterilization for formulations and warm deodorant sterilization timber
US20040101546A1 (en) 2002-11-26 2004-05-27 Gorman Anne Jessica Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents
JP3975944B2 (en) 2003-02-27 2007-09-12 住友電気工業株式会社 Semiconductor or liquid crystal manufacturing device supporting and semiconductor or liquid crystal manufacturing apparatus equipped with it
US7125821B2 (en) 2003-09-05 2006-10-24 Exxonmobil Chemical Patents Inc. Low metal content catalyst compositions and processes for making and using same
CA2545813C (en) 2003-11-14 2011-01-04 Shanghai Genomics, Inc. The derivatives of pyridone and use thereof
GB0407502D0 (en) 2004-04-02 2004-05-05 Inotec Amd Ltd Hyperbaric dressing
US20050248270A1 (en) 2004-05-05 2005-11-10 Eastman Kodak Company Encapsulating OLED devices
US8916208B2 (en) 2004-06-24 2014-12-23 California Institute Of Technology Aluminophosphate-based materials for the treatment of wounds
CN101160143A (en) 2005-02-15 2008-04-09 弗吉尼亚大学 Mineral technologies (mt) for acute hemostasis and for the treatment of acute wounds and chronic ulcers
US20060211971A1 (en) 2005-03-16 2006-09-21 Z-Medica, Llc Pillow for the delivery of blood clotting materials to a wound site
US20060211965A1 (en) 2005-03-16 2006-09-21 Z-Medica, Llc Device for the delivery of blood clotting materials to a wound site
US9326995B2 (en) 2005-04-04 2016-05-03 The Regents Of The University Of California Oxides for wound healing and body repair
US20060282046A1 (en) 2005-04-13 2006-12-14 Horn Jeffrey L Device and method for subcutaneous delivery of blood clotting agent
EP1714642A1 (en) 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
US8063264B2 (en) 2005-08-26 2011-11-22 Michael Spearman Hemostatic media
JP2007144154A (en) 2005-11-07 2007-06-14 Jeffrey L Horn Devices for delivery of molecular sieve materials for formation of blood clots
US20070142783A1 (en) 2005-12-16 2007-06-21 Huey Raymond J Devices and methods for promoting the formation of blood clots at dialysis access sites
US20070154509A1 (en) 2005-12-30 2007-07-05 Wilcher Steve A Adsorbent-Containing Hemostatic Devices
US20070154510A1 (en) 2005-12-30 2007-07-05 Wilcher Steve A Adsorbent-Containing Hemostatic Devices
US8409629B2 (en) 2006-01-09 2013-04-02 Jack Mentkow Hemostatic agent composition and method of delivery
US9474652B2 (en) 2006-01-09 2016-10-25 Jack Mentkow Hemostatic agent delivery system
US8277837B2 (en) 2006-01-11 2012-10-02 Entegrion, Inc. Hemostatic textile
US20070167971A1 (en) 2006-01-17 2007-07-19 Raymond Huey Devices and methods for promoting the formation of blood clots in esophageal varices
US8938898B2 (en) 2006-04-27 2015-01-27 Z-Medica, Llc Devices for the identification of medical products
US7968114B2 (en) 2006-05-26 2011-06-28 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US20070276308A1 (en) 2006-05-26 2007-11-29 Huey Raymond J Hemostatic agents and devices for the delivery thereof
CN101495096A (en) 2006-05-30 2009-07-29 伊兰制药国际有限公司 Nanoparticulate posaconazole formulations
CN1970090B (en) 2006-09-14 2015-11-25 华东理工大学 Mesoporous xerogel hemostatic material and its preparation method and application
WO2008036225A3 (en) 2006-09-20 2008-05-15 Entek Mfg Inc Conformable structured therapeutic dressing
US8703634B2 (en) 2007-02-21 2014-04-22 The Regents Of The University Of California Hemostatic compositions and methods of use
US20080206134A1 (en) 2007-02-22 2008-08-28 Denny Lo Radio-opaque hemostatic agents and devices and methods for the delivery thereof
US20080254147A1 (en) 2007-04-13 2008-10-16 Z-Medica Corporation Method of providing hemostasis in anti-coagulated blood
CN101104080B (en) 2007-04-24 2011-06-22 深圳市鸿华投资有限公司 Zeolite hemostatic dressings and preparation method and application thereof
WO2008153714A1 (en) 2007-05-22 2008-12-18 Virginia Commonwealth University Hemostatic mineral compositions and uses thereof
US20080317831A1 (en) 2007-06-21 2008-12-25 Denny Lo Hemostatic sponge and method of making the same
US20090162406A1 (en) 2007-09-05 2009-06-25 Z-Medica Corporation Wound healing with zeolite-based hemostatic devices

Patent Citations (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2969145A (en) * 1956-05-07 1961-01-24 Johnson & Johnson Packaged adhesive bandage
US3122140A (en) * 1962-03-29 1964-02-25 Johnson & Johnson Flexible absorbent sheet
US3189227A (en) * 1962-12-07 1965-06-15 American Home Prod Fluid dispenser
US3181231A (en) * 1963-08-06 1965-05-04 Union Carbide Corp Molecular sieve-metal agglomerates and their preparation
US3366578A (en) * 1964-12-07 1968-01-30 Universal Oil Prod Co Zeolite and method for making the improved zeolite
US3386802A (en) * 1967-07-28 1968-06-04 Universal Oil Prod Co Method for preparing spherically-shaped crystalline zeolite particles
US3723352A (en) * 1971-01-25 1973-03-27 Air Prod & Chem Supported silver catalysts
US3698392A (en) * 1971-04-21 1972-10-17 Kewanee Oil Co Topical dressing
US4435512A (en) * 1980-11-28 1984-03-06 Nippondenso Co., Ltd. Process for producing cordierite ceramic products
US4379143A (en) * 1980-12-05 1983-04-05 Pq Corporation Topical liquid or ointment
US4374044A (en) * 1981-01-19 1983-02-15 General Motors Corporation Cordierite bead catalyst support and method of preparation
US4373519A (en) * 1981-06-26 1983-02-15 Minnesota Mining And Manufacturing Company Composite wound dressing
US4460642A (en) * 1981-06-26 1984-07-17 Minnesota Mining And Manufacturing Company Water-swellable composite sheet of microfibers of PTFE and hydrophilic absorptive particles
US4524064A (en) * 1982-05-26 1985-06-18 Nippon Oil Company, Limited Wound-covering materials
US4525410A (en) * 1982-08-24 1985-06-25 Kanebo, Ltd. Particle-packed fiber article having antibacterial property
US4569343A (en) * 1982-09-30 1986-02-11 Firma Carl Freudenberg Skin application medicament
US4911898A (en) * 1983-01-21 1990-03-27 Kanebo Limited Zeolite particles retaining silver ions having antibacterial properties
US4828832A (en) * 1983-09-07 1989-05-09 Laboratorios Biochemie De Mexico Method of manufacturing a composition for treating skin lesions
US4514510A (en) * 1983-09-08 1985-04-30 American Colloid Company Hydrogen enriched water swellable clay having reduced acid demand and stable at low pH
US4822349A (en) * 1984-04-25 1989-04-18 Hursey Francis X Method of treating wounds
US4748978A (en) * 1984-09-27 1988-06-07 Kamp Herman F Therapeutic dressing having mineral components
US4651725A (en) * 1985-04-18 1987-03-24 Unitika Ltd. Wound dressing
US4717735A (en) * 1986-04-10 1988-01-05 European Body Wrap, Inc. Composition for body wrap
US5599578A (en) * 1986-04-30 1997-02-04 Butland; Charles L. Technique for labeling an object for its identification and/or verification
US4728323A (en) * 1986-07-24 1988-03-01 Minnesota Mining And Manufacturing Company Antimicrobial wound dressings
US4828081A (en) * 1988-03-04 1989-05-09 Samsonite Corporation Luggage identification system
US5716337A (en) * 1992-06-10 1998-02-10 Johnson & Johnson Medical, Inc. Absorbent product
US5597581A (en) * 1993-07-09 1997-01-28 Karl W. An Haak Chitosan foil for wound sealing and process for its preparation
US5725551A (en) * 1993-07-26 1998-03-10 Myers; Gene Method and apparatus for arteriotomy closure
US5486195A (en) * 1993-07-26 1996-01-23 Myers; Gene Method and apparatus for arteriotomy closure
US5502042A (en) * 1994-07-22 1996-03-26 United States Surgical Corporation Methods and compositions for treating wounds
US5728451A (en) * 1994-11-28 1998-03-17 Langley; John D. Breathable non-woven composite viral penetration barrier fabric and fabrication process
US5801116A (en) * 1995-04-07 1998-09-01 Rhodia Inc. Process for producing polysaccharides and their use as absorbent materials
US5766715A (en) * 1995-04-10 1998-06-16 Michel Garçonnet Compact disposable packing that forms a kit
US5855570A (en) * 1995-04-12 1999-01-05 Scherson; Daniel A. Oxygen producing bandage
US6251423B1 (en) * 1995-05-20 2001-06-26 Smith & Nephew Plc Sterilizable paste product for topical application
US6700032B1 (en) * 1996-03-07 2004-03-02 Leatherite Pty Limited Wound care management
US6037280A (en) * 1997-03-21 2000-03-14 Koala Konnection Ultraviolet ray (UV) blocking textile containing particles
US5916511A (en) * 1997-08-19 1999-06-29 Ngk Insulators, Ltd. Production method of cordierite ceramic honeycomb structure
US6372333B1 (en) * 1998-02-25 2002-04-16 Rengo Co., Ltd. Composition containing inorganic porous crystals-hydrophilic macromolecule composite and product made therefrom
US20020077653A1 (en) * 1998-04-08 2002-06-20 Hudson John Overton Hemostatic system for body cavities
US6060461A (en) * 1999-02-08 2000-05-09 Drake; James Franklin Topically applied clotting material
US6203512B1 (en) * 1999-06-28 2001-03-20 The Procter & Gamble Company Method for opening a packaging device and retrieving an interlabial absorbent article placed therein
US6187347B1 (en) * 2000-02-09 2001-02-13 Ecosafe, Llc. Composition for arresting the flow of blood and method
US6523778B2 (en) * 2000-06-29 2003-02-25 The Night Fun Co., Llc Illuminated emergency signaling device and flying balloon
US6685227B2 (en) * 2000-07-14 2004-02-03 Safer Sleep Limited Label, a label system and method
US6573419B2 (en) * 2000-08-25 2003-06-03 Sody Naimer Elastic adhesive wound dressing for control of bleeding and for dressing bleeding wounds
US20030018357A1 (en) * 2001-05-09 2003-01-23 Luthra Ajay K. Wound closure system and methods
US20060141018A1 (en) * 2001-12-31 2006-06-29 Crosslink-D, Incorporated, A Delaware Corporation Hemostatic compositions and methods for controlling bleeding
US20050119112A1 (en) * 2002-01-22 2005-06-02 Zeochem, Llc Process for production of molecular sieve adsorbent blends
US6998510B2 (en) * 2002-02-04 2006-02-14 Damage Control Surgical Technologies, Inc. Method and apparatus for improved hemostasis and damage control operations
US20040038893A1 (en) * 2002-06-07 2004-02-26 Dyax Corp. Prevention and reduction of blood loss
US20090018479A1 (en) * 2002-06-14 2009-01-15 Hemcon Medical Technologies, Inc. Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chistosan
US7371403B2 (en) * 2002-06-14 2008-05-13 Providence Health System-Oregon Wound dressing and method for controlling severe, life-threatening bleeding
US20040005350A1 (en) * 2002-06-28 2004-01-08 Looney Dwayne Lee Hemostatic wound dressings and methods of making same
US6745720B2 (en) * 2002-10-29 2004-06-08 Cycle Group Limited Of Delaware Clumping animal litter and method of making same
US6890177B2 (en) * 2002-12-02 2005-05-10 Centrix, Inc. Method and device for the retraction and hemostasis of tissue during crown and bridge procedures
US6701649B1 (en) * 2002-12-12 2004-03-09 Gunter Brosi Combat identification marker
US20040121438A1 (en) * 2002-12-19 2004-06-24 Stephen Quirk Wound care compositions
US20050023956A1 (en) * 2003-07-29 2005-02-03 Samsung Sdi Co., Ltd. Flat panel display
US20050070693A1 (en) * 2003-07-31 2005-03-31 Immunomedics, Inc. Therapy using anti-CD-19 antibodies
US20050107826A1 (en) * 2003-08-14 2005-05-19 Zhu Yong H. Vascular wound closure device and method
US20050143689A1 (en) * 2003-08-17 2005-06-30 Ramsey Maynard Iii Internal compression tourniquet catheter system and method for wound track navigation and hemorrhage control
US20050074505A1 (en) * 2003-09-12 2005-04-07 Hursey Francis X. Calcium zeolite hemostatic agent
US20050058721A1 (en) * 2003-09-12 2005-03-17 Hursey Francis X. Partially hydrated hemostatic agent
US20050118230A1 (en) * 2003-10-22 2005-06-02 Encelle, Inc. Methods and compositions for regenerating connective tissue
US20050137512A1 (en) * 2003-12-23 2005-06-23 Campbell Todd D. Wound dressing and method for controlling severe, life-threatening bleeding
US20060034935A1 (en) * 2004-07-22 2006-02-16 Pronovost Allan D Compositions and methods for treating excessive bleeding
US20060078628A1 (en) * 2004-10-09 2006-04-13 Karl Koman Wound treating agent
US20060116635A1 (en) * 2004-11-29 2006-06-01 Med Enclosure L.L.C. Arterial closure device
US20060121101A1 (en) * 2004-12-08 2006-06-08 Ladizinsky Daniel A Method for oxygen treatment of intact skin
US20090074880A1 (en) * 2004-12-08 2009-03-19 Ladizinsky Daniel A Method for oxygen treatment of intact skin
US20060141060A1 (en) * 2004-12-27 2006-06-29 Z-Medica, Llc Molecular sieve materials having increased particle size for the formation of blood clots
US20070065491A1 (en) * 2005-02-09 2007-03-22 Z-Medica Corporation Devices and methods for the delivery of blood clotting materials to bleeding wounds
US20130041332A1 (en) * 2005-02-09 2013-02-14 Z-Medica Corporation Devices and methods for the delivery of blood clotting materials to bleeding wounds
US20100121244A1 (en) * 2005-02-09 2010-05-13 Z-Medica Corporation Devices and methods for the delivery of molecular sieve materials for the formation of blood clots
US20090008261A1 (en) * 2005-03-03 2009-01-08 Cambridge Enterprise Limited Oxygen Generation Apparatus and Method
US20070031515A1 (en) * 2005-04-04 2007-02-08 Stucky Galen D Inorganic materials for hemostatic modulation and therapeutic wound healing
US20070016152A1 (en) * 2005-07-14 2007-01-18 Boehringer Laboratories, Inc. System for treating a wound with suction and method detecting loss of suction
US20070104792A1 (en) * 2005-09-13 2007-05-10 Elan Pharma International, Limited Nanoparticulate tadalafil formulations
US20070104768A1 (en) * 2005-11-07 2007-05-10 Z-Medica Corporation Devices for the delivery of molecular sieve materials for the formation of blood clots
US20090076475A1 (en) * 2005-11-09 2009-03-19 Oxysure Systems Inc. Method and apparatus for delivering therapeutic oxygen treatments
US20130079695A1 (en) * 2006-05-26 2013-03-28 Z-Medica, Llc Hemostatic sponge
US20120130296A1 (en) * 2006-05-26 2012-05-24 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US8114433B2 (en) * 2006-05-26 2012-02-14 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US8383148B2 (en) * 2006-05-26 2013-02-26 Z-Medica, Llc Clay-based hemostatic agents and devices for the delivery thereof
US20070276345A1 (en) * 2006-05-26 2007-11-29 Raymond Huey Clay-based hemostatic agents and devices for the delivery thereof
US20080027365A1 (en) * 2006-06-01 2008-01-31 Huey Raymond J Hemostatic device with oxidized cellulose pad
US20080085300A1 (en) * 2006-10-06 2008-04-10 Z-Medica Corporation Hemostatic compositions and method of manufacture
US20080097271A1 (en) * 2006-10-20 2008-04-24 Z-Medica Corporation Devices and methods for the delivery of hemostatic agents to bleeding wounds
US20080125686A1 (en) * 2006-11-29 2008-05-29 Denny Lo Heat mitigating hemostatic agent
US20090043268A1 (en) * 2007-08-06 2009-02-12 Eddy Patrick E Wound treatment system and suction regulator for use therewith
US20090047366A1 (en) * 2007-08-15 2009-02-19 Bedard Robert L Inorganic Coagulation Accelerators for Individuals taking Platelet Blockers or Anticoagulants
US20090053288A1 (en) * 2007-08-20 2009-02-26 Eskridge Jr E Stan Hemostatic woven fabric
US20090112170A1 (en) * 2007-10-26 2009-04-30 Electrochemical Oxygen Concepts, Inc Apparatus and methods for controlling tissue oxygenation for wound healing and promoting tissue viability
US20090123525A1 (en) * 2007-11-09 2009-05-14 Bedard Robert L Adsorbent-Containing Hemostatic Devices
US20110064785A1 (en) * 2007-12-06 2011-03-17 Nanosys, Inc. Nanostructure-Enhanced Platelet Binding and Hemostatic Structures
US20110059287A1 (en) * 2008-01-21 2011-03-10 Imerys Pigments, Inc. Fibers comprising at least one filler, processes for their production, and uses thereof
US20100035045A1 (en) * 2008-01-21 2010-02-11 Imerys Pigments, Inc. Fibers comprising at least one filler and processes for their production
US20110015565A1 (en) * 2009-07-15 2011-01-20 Hursey Francis X Gas dispenser with therapeutic agent
US20120004636A1 (en) * 2010-07-02 2012-01-05 Denny Lo Hemostatic fibrous material
US20120070470A1 (en) * 2010-09-22 2012-03-22 Z-Medica Corporation Hemostatic compositions, devices, and methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Webster's Dictionary definition of "expose" (1993) *

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8475658B2 (en) 2003-01-29 2013-07-02 Molycorp Minerals, Llc Water purification device for arsenic removal
US8252344B2 (en) 2003-09-12 2012-08-28 Z-Medica Corporation Partially hydrated hemostatic agent
US8257731B2 (en) 2005-02-09 2012-09-04 Z-Medica Corporation Devices and methods for the delivery of molecular sieve materials for the formation of blood clots
US8512743B2 (en) 2005-02-09 2013-08-20 Z-Medica, Llc Devices and methods for the delivery of molecular sieve materials for the formation of blood clots
US8557278B2 (en) 2005-02-09 2013-10-15 Z-Medica, Llc Devices and methods for the delivery of blood clotting materials to bleeding wounds
US8938898B2 (en) 2006-04-27 2015-01-27 Z-Medica, Llc Devices for the identification of medical products
US8343537B2 (en) 2006-05-26 2013-01-01 Z-Medica, Llc Clay-based hemostatic agents and devices for the delivery thereof
US9078782B2 (en) 2006-05-26 2015-07-14 Z-Medica, Llc Hemostatic fibers and strands
US8257732B2 (en) 2006-05-26 2012-09-04 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US8202532B2 (en) 2006-05-26 2012-06-19 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US9333117B2 (en) 2006-05-26 2016-05-10 Z-Medica, Llc Clay-based hemostatic agents and devices for the delivery thereof
US8383148B2 (en) 2006-05-26 2013-02-26 Z-Medica, Llc Clay-based hemostatic agents and devices for the delivery thereof
US8846076B2 (en) 2006-05-26 2014-09-30 Z-Medica, Llc Hemostatic sponge
US8460699B2 (en) 2006-05-26 2013-06-11 Z-Medica, Llc Clay-based hemostatic agents and devices for the delivery thereof
US8114433B2 (en) 2006-05-26 2012-02-14 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US9867898B2 (en) 2006-05-26 2018-01-16 Z-Medica, Llc Clay-based hemostatic agents
US7968114B2 (en) 2006-05-26 2011-06-28 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US8784876B2 (en) 2006-05-26 2014-07-22 Z-Medica, Llc Clay-based hemostatic agents and devices for the delivery thereof
US10086106B2 (en) 2006-05-26 2018-10-02 Z-Medica, Llc Clay-based hemostatic agents
US8066874B2 (en) 2006-12-28 2011-11-29 Molycorp Minerals, Llc Apparatus for treating a flow of an aqueous solution containing arsenic
US8557730B2 (en) 2007-10-31 2013-10-15 Molycorp Minerals, Llc Composition and process for making the composition
US8349764B2 (en) 2007-10-31 2013-01-08 Molycorp Minerals, Llc Composition for treating a fluid
US8252087B2 (en) 2007-10-31 2012-08-28 Molycorp Minerals, Llc Process and apparatus for treating a gas containing a contaminant
US9889154B2 (en) 2010-09-22 2018-02-13 Z-Medica, Llc Hemostatic compositions, devices, and methods
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
US9233863B2 (en) 2011-04-13 2016-01-12 Molycorp Minerals, Llc Rare earth removal of hydrated and hydroxyl species
US9408913B2 (en) 2011-09-12 2016-08-09 Protege Biomedical, Llc Composition and dressing for wound treatment
WO2013040080A1 (en) * 2011-09-12 2013-03-21 Protege Biomedical, Llc Composition and dressing for wound treatment
CN102366640A (en) * 2011-10-14 2012-03-07 浙江安吉华埠实业有限公司 Zeolite tourniquet bandage
US9603964B2 (en) 2012-06-22 2017-03-28 Z-Medica, Llc Hemostatic devices
US9072806B2 (en) 2012-06-22 2015-07-07 Z-Medica, Llc Hemostatic devices
US9352066B2 (en) 2012-06-22 2016-05-31 Z-Medica, Llc Hemostatic devices
US9975787B2 (en) 2014-03-07 2018-05-22 Secure Natural Resources Llc Removal of arsenic from aqueous streams with cerium (IV) oxide compositions

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