US20090234377A1 - Medical closure device - Google Patents

Medical closure device Download PDF

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Publication number
US20090234377A1
US20090234377A1 US12/076,246 US7624608A US2009234377A1 US 20090234377 A1 US20090234377 A1 US 20090234377A1 US 7624608 A US7624608 A US 7624608A US 2009234377 A1 US2009234377 A1 US 2009234377A1
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United States
Prior art keywords
loop
filament
closure device
member
medical closure
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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US12/076,246
Inventor
Fredrik Mahlin
Fredrik Preinitz
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St Jude Medical Systems AB
Original Assignee
St Jude Medical Systems AB
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Publication date
Application filed by St Jude Medical Systems AB filed Critical St Jude Medical Systems AB
Priority to US12/076,246 priority Critical patent/US20090234377A1/en
Assigned to RADI MEDICAL SYSTEMS AB reassignment RADI MEDICAL SYSTEMS AB ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MAHLIN, FREDRIK, PREINITZ, FREDRIK
Publication of US20090234377A1 publication Critical patent/US20090234377A1/en
Assigned to ST. JUDE MEDICAL SYSTEMS AB reassignment ST. JUDE MEDICAL SYSTEMS AB CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: RADI MEDICAL SYSTEMS AB
Application status is Abandoned legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00646Type of implements
    • A61B2017/00659Type of implements located only on one side of the opening
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00778Operations on blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0446Means for attaching and blocking the suture in the suture anchor
    • A61B2017/0461Means for attaching and blocking the suture in the suture anchor with features cooperating with special features on the suture, e.g. protrusions on the suture

Abstract

A medical closure device (1; 20) comprising an inner member (2; 23), which is adapted to be positioned against an inner surface of a tissue wall, and a retaining member (3; 13; 21), which is attached to the inner member, wherein the retaining member is in the form of a loop made up by multiple coils of at least one filament, the coils lying side-by-side one another such that when increasing tension is applied in the loop, at least one of the at least one filament breaks apart before side-by-side portions of the at least one filament slide readily with respect to one another.

Description

    FIELD OF THE INVENTION
  • The present invention relates generally to the field of sealing or closure devices for, e.g., the sealing of a percutaneous puncture in a vessel wall, and in particular to the class of sealing devices that comprises an intra-arterial member, which is held in place by a retaining member, and more particular to the special characteristics of this retaining member.
  • BACKGROUND OF THE INVENTION
  • In U.S. Pat. No. 6,508,828, which is assigned to the present assignee and whose entire contents are incorporated herein by reference for the sealing devices and methods disclosed therein, a sealing device is disclosed for sealing a puncture hole in a vessel wall. This sealing device comprises an inner sealing member, an outer locking member, and a retaining member. The inner sealing member is adapted to be positioned at an inner surface of the vessel wall, while the outer member is adapted to be positioned at an outer surface of the vessel wall. In use, the inner and outer members sandwich the vessel wall, and are held together by the retaining member, to thereby seal the puncture hole in the vessel wall. Other examples of sealing devices that comprise an inner member and an outer member, which are held together by an elongated retaining member, can be found in, for example, U.S. Pat. Nos. 5,593,422 and 5,620,461.
  • The retaining member can be provided in the form of a loop, which has been made from a thread, suture, monofilament, multifilament, or some other thread-like structure, the ends of which have been joined together by means of a knot. As an alternative, the ends of the thread-like element can be glued together to thereby form a loop.
  • In the U.S. Patent Application Publications Nos. 2005/0137625 and 2007/0239209, whose entire contents are incorporated herein by reference for the sealing devices and methods disclosed therein, the drawbacks with knotting and gluing are discussed, and an alternative approach is presented, wherein the ends of, for example, a suture are joined together by embedding one portion of the suture within another portion of the same suture, such that as tension in the suture increases, the different suture portions are held together by the friction then acting between these suture portions.
  • The present invention is therefore directed to an improved method of joining an elongated, thread-like element into a loop suitable for holding at least an inner member being part of a sealing device in place, and a general object of the invention is to provide a sealing device comprising an inner member which is attached to a loop, which is manufactured by this improved method.
  • SUMMARY OF THE INVENTION
  • The above-mentioned object is achieved with a medical sealing device comprising an inner member which is attached to a retaining member described herein.
  • As was stated above, in a medical sealing or closure device it is generally known to hold an inner member thereof by means of a retaining member, which can be provided in the form of a suture or filament. The sealing device is usually delivered into a puncture hole by some kind of insertion and positioning assembly, and to arrange the retaining member in the form of a loop provides thereby certain advantages, because a loop can easily be attached to and handled by the other elements of the insertion and positioning assembly. For this reason it is less favorable to produce a loop from a thread whose ends are tied together, because there is a risk that the resulting knot gets stuck in the insertion and positioning assembly during the delivery procedure. To create a loop by gluing together the ends of a thread is also less practical, because, for example, glue has to harden, and care must be taken to ensure that there is no excess glue that can contaminate the other parts of the insertion and positioning assembly and thereby jeopardize its proper functioning. The most elegant way of creating a loop is perhaps to thread one portion of, for example, a suture into another portion of the same suture, such that when the suture is subjected to tension, friction between the suture portions increases and holds the loop intact. The threading of one portion of a suture into another portion of the suture is, however, a rather time-consuming procedure, and requires a considerable amount of manual dexterity to manufacture, and is less suited for large-scale production.
  • In contrast, the present invention introduces a novel technique for providing a retaining member in the form of a loop made from a thread-like structure. Herein the term “filament” will be used as a common term for all kinds of thread-like structures, including but not limited to threads, sutures, fibers, monofilaments, multifilaments, etc. According to one embodiment of the invention, a loop is created by winding up a single filament multiple times, to thereby create a knotless loop, which holds together purely due to the friction acting between the individual filament coils. It has been found that the winding preferably should be performed at least ten (10), and more preferably at least twenty (20) times, to thereby create a loop comprising at least ten and more preferably at least twenty turns or coils, all made up from the same filament.
  • In another embodiment of the invention, several individual filaments are (preferably simultaneously) wound multiple times into one common loop comprising several coils of each individual filament. In this embodiment, the preferred number of windings can be somewhat smaller, but at least five (5), and more preferably at least ten (10), windings should be performed, such that in the loop an individual filament is represented by at least five and more preferably by at least ten turns or coils. Another way of expressing this feature of a knotless loop according to the present invention is to say that in a cross-section of the loop there are at least five, and more preferably at least ten, smaller cross-sections present, which all originate from the same filament. The number of windings (coils) could, however, be much larger, and for a thin monofilament, the number of coils could exceed one hundred, or even be in excess of two or three hundred, depending on, in particular, the surface characteristics of the filament used.
  • To prevent any tendency of unwinding of the filament(s) in a loop, some adherent material or property can be provided to cause the filaments to adhere to one another. Such an adherent, which could be an adhesive or a tacky material, e.g. wax or grease, or a conventional suture coating material, can be applied either to the surface of the loop itself, or to the surface of the individual filaments constituting the loop. Herein, the term “adherent” is meant to encompass all such adherent materials. An adherent should, however, not be confused with an adhesive such as glue which is used as the actual means that holds the loop together. Herein, an adherent is mainly used to prevent the filaments of the loop from fraying, but such an adherent can also increase the friction between the surfaces of neighbouring filament coils in a loop.
  • In a particular embodiment of a loop according to the present invention, the loop can be provided with a thickened section created by winding at least one filament around a portion of the loop, i.e. this thickening winding is perpendicular to the coils making up the loop itself. Such a thickened section can, in a sealing device comprising an outer member, be used for friction locking of the outer member. A friction lock for an outer member is disclosed in, for example, the above-referenced U.S. Pat. No. 6,508,828, whose entire contents are incorporated herein by reference.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 a illustrates schematically a sealing device comprising an inner member and a retaining loop member according to a first embodiment of the present invention.
  • FIG. 1 b shows a cross-section taken at B-B of the loop member shown in FIG. 1 a.
  • FIG. 2 shows a cross-section of an alternative retaining loop member according to a second embodiment of the present invention.
  • FIG. 3 illustrates a sealing device comprising an outer member, an inner member, and a retaining loop member according to another embodiment of the present invention.
  • DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
  • For ease of understanding, embodiments of the present invention will be described with reference to a sealing device adapted for the sealing of a percutaneous puncture in a vessel wall, such as an artery wall. The invention could, however, be applied to other types of medical sealing or closure devices, for example devices for the closing of an opening or defect in a patient's heart (e.g. a so-called patent foramen ovale).
  • In FIG. 1 a, a first embodiment of a sealing device 1 comprising an inner member 2 and retaining member 3 in the form of a loop 3 according to the present invention is schematically illustrated. The inner member 2 is adapted to be introduced into a vessel (for example, a blood vessel) and positioned at an inner surface of the vessel wall, where the inner member 2 is held in place by tension applied in the retaining member 3. The retainer loop 3 has been created by winding up a thin filament multiple times such that the loop 3 has several coils of the same filament. Depending on in particular the surface characteristics of the filament used, the number of windings can easily be made sufficiently large such that a loop that holds together without the use of, for example, a knot or glue is produced. To prevent any tendency of the filament coils to fray, an adherent, like wax or suture coating, can be applied to the surface of the filament during winding. As an alternative, an adherent could be applied to the surface of the loop after the loop has been produced. Such an adherent can also enhance the friction characteristics of the filament surface, such that fewer turns are needed to create a loop that reliably holds together.
  • FIG. 1 b illustrates very schematically a cross-section of the loop 3 shown in FIG. 1 a. The cross-section of FIG. 1 b, which is taken at B-B in FIG. 1 a, is only intended to show that in a cross-section of a loop according to the first embodiment of the present invention, the same filament appears multiple times, in this case over hundred times. By providing multiple coils of the same filament, a loop which reliably holds together can thus be provided without using any knotting or gluing techniques.
  • In FIG. 2 a cross-section of a second embodiment of a loop 13 according to the present invention is schematically illustrated. In this embodiment, several monofilaments have simultaneously been wound multiple times to create a composite loop 13. For illustrating purposes the number of monofilaments has been reduced to five (5), and the number of turns is ten (10), resulting in that each monofilament appears ten times in the cross-section and that the cross-section comprises a total of fifty (50) individual monofilament cross-sections. In practise, it may be preferred that these numbers, for example, are doubled, i.e. the number of monofilaments is ten (10) and the number of coils is twenty (20). It should, however, be emphasized that for a given situation, the adequate number of monofilaments as well as the adequate number of turns are very easily established by a few simple trials.
  • A similar way of manufacture a loop comprising multiple coils of the same filaments is to wind a multifilament multiple times. A multifilament consists of several filaments, which, for example, have been braided or twined into a multifilament. Also in this case, the result of the winding process is that a cross-section of the loop comprises several individual filament cross-sections, i.e. very similar to the cross-section shown in FIG. 2. In a test it was demonstrated that by winding a multifilament several times and thus providing a loop comprising several coils of the same filaments, the resulting loop would rather break than be drawn apart when large tension was applied. The test data is summarized in Table 1 below.
  • Maximum tension applied
    Number of to loop (Newton) just prior
    coils to failure Mode of failure
    2 4.3 Sliding
    4 11.5 Break
    8 33.5 Break
    20 79.0 Break
    30 108.1 Break
  • Table 1 shows the test results for a multifilament braided from twenty (20) filaments made from a segmented copolymer composed of L,L-lactide, trimethylene carbonate and ε-caprolactone with the weight percentage 88:8:4 and made by Poly-Med, Inc., South Carolina, U.S. The multifilament was wound into loops consisting of different numbers of coils. Each loop was then subjected to tension, and the maximum tension (in Newton) before failure as well as mode of failure were recorded. To prevent any unravelling tendencies of the loops, an adherent in the form of ordinary hair wax (Sportin' Waves® sold by Soft Sheen Products, Inc., Illinois, U.S.) was applied to the surface of the loops. As evident from Table 1, when the multifilament was wound only two (2) times, the mode of failure was sliding, whereas already four (4) windings produced a loop which instead broke. Herein, the failure mode “break” indicates that the filaments themselves break apart, while the failure mode “sliding” indicates that the filaments slide readily with respect to one another such that the loop unravels. The term “readily” is meant to distinguish this catastrophic unravelling of the filaments in a loop from a small and insignificant (initial) displacement or rearrangement of the filaments in a loop. Such a displacement or rearrangement can typically occur at the start of the tensioning of the loop in question.
  • The general purpose of a loop according to the invention is to function as a retaining member in a sealing device, wherein the retaining member holds an inner member. When the sealing device further comprises an outer member, which can slide along the retaining member until it is to be held in place by a friction lock created between the retaining member and a bore or hole in the outer member, a loop according to the invention can preferably be provided with a thickened portion. This thickened portion is advantageously also provided as a knotless portion in that one or several filaments are wound around a portion of a loop already created in accordance with the method described above. The windings of this thickened portion are thus directed perpendicular to the windings (or coils) of the basic loop. Alternatively, the transverse coils of a thickened portion can be made by winding of at least one filament which is not a continuous part of a filament forming the basic longitudinal loop.
  • Such a thickened portion is disclosed in FIG. 3, where a loop 21 is provided with a thickened portion 22 is schematically illustrated. A corresponding sealing device 20 can consequently comprise a retaining member 21 in the form of the loop 21 with the thickened portion 22, an inner member 23, which is connected to the retaining member 21, and an outer member 24, which is slidably attached to the retaining member 21 by a bore, which has been made through the outer member 24 and through which the loop 21 has been threaded. When the sealing device 20 is positioned at a vessel wall in order to stop bleeding through a puncture hole made therein, the inner member 23 is first positioned at an inner surface of the vessel wall, and then the outer member 24 is slid along the retaining member 21 until it is pushed up and over the thickened portion 22 into contact with an outer surface of the vessel wall, such that the inner member 23 and the outer member 24 sandwich the vessel wall and the outer member 24 is held in place by friction acting on the thickened portion 22 of the loop 21 and the bore made in the outer member 24, to thereby seal the puncture hole made in the vessel wall. As should be appreciated from FIG. 3, the thickened portion 22 has been created by multiple winding of at least one filament around a portion of the basic loop 21. The number of windings around the main loop 21 can easily be increased until the thickness of the thickened portion 22 is sufficiently large to reliably hold the outer member 24 in place.
  • As with the first embodiment of the invention shown in FIGS. 1 a and 1 b, the loop 21 including the thickened portion 22 can be provided with an adherent, whose main purpose is to prevent any fraying tendencies of the filaments constituting the loop 21 and the thickened portion 22. Such an adherent can also enhance the friction acting between neighbouring filament coils in the loop, such that less coils are needed to provide a loop that reliably holds together.
  • Although the present invention has been described with reference to specific embodiments, also shown in the appended drawings, it will be apparent to those skilled in the art that many variations and modifications can be done within the scope of the invention as described in the specification and defined with reference to the claims below. It is in particular contemplated that the number of windings and thereby the number of resulting coils of a loop can range from a rather small number, e.g. five or ten, to a rather large number like several hundreds, depending on the specifics of the filament(s) used and the final strength required. A suitable number can easily be determined by a few simple experiments.

Claims (5)

1. A medical closure device (1; 20) comprising an inner member (2; 23), which is adapted to be positioned against an inner surface of a tissue wall, and a retaining member (3; 13; 21), which is attached to the inner member, wherein the retaining member is in the form of a loop made up by multiple coils of at least one filament, the coils lying side-by-side one another such that when increasing tension is applied in the loop, at least one of the at least one filament breaks apart before side-by-side portions of the at least one filament slide readily with respect to one another.
2. A medical closure device according to claim 1, wherein the closure device further comprises an outer member (24), which is adapted to be positioned against an outer surface of the tissue wall, wherein the retaining member is provided with a thickened portion (22) made by multiple winding of at least one filament around the circumference of a portion of the loop.
3. A medical closure device according to claim 1, wherein the loop is knotless.
4. A medical closure device according to claim 1, wherein the medical closure device is adapted for closing a puncture in a vessel wall.
5. A medical closure device according to claim 1, wherein the medical closure device is adapted for closing a septal defect in a heart.
US12/076,246 2008-03-14 2008-03-14 Medical closure device Abandoned US20090234377A1 (en)

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Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US12/076,246 US20090234377A1 (en) 2008-03-14 2008-03-14 Medical closure device
US12/921,993 US8308762B2 (en) 2008-03-14 2009-03-10 Medical closure device
PCT/IB2009/000478 WO2009112930A2 (en) 2008-03-14 2009-03-10 Medical closure device
EP09720559.5A EP2173256B1 (en) 2008-03-14 2009-03-10 Medical closure device
AU2009223926A AU2009223926B2 (en) 2008-03-14 2009-03-10 Medical closure device
CA 2695872 CA2695872A1 (en) 2008-03-14 2009-03-10 Medical closure device
JP2010550280A JP5624895B2 (en) 2008-03-14 2009-03-10 Medical closure device
CR11377A CR11377A (en) 2008-03-14 2010-04-19 Closing device for medical use

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US12/921,993 Continuation US8308762B2 (en) 2008-03-14 2009-03-10 Medical closure device
US12/921,993 Continuation-In-Part US8308762B2 (en) 2008-03-14 2009-03-10 Medical closure device

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US20090234377A1 true US20090234377A1 (en) 2009-09-17

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US12/921,993 Active 2028-07-15 US8308762B2 (en) 2008-03-14 2009-03-10 Medical closure device

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EP (1) EP2173256B1 (en)
JP (1) JP5624895B2 (en)
AU (1) AU2009223926B2 (en)
CA (1) CA2695872A1 (en)
CR (1) CR11377A (en)
WO (1) WO2009112930A2 (en)

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US20110029014A1 (en) * 2008-03-14 2011-02-03 St. Jude Medical Systems Ab Medical closure device
US20110213414A1 (en) * 2008-02-15 2011-09-01 Mcguckin Jr James F Vascular hole closure device
US20120143249A1 (en) * 2010-12-03 2012-06-07 Boston Scientific Scimed, Inc. Closure device
WO2013133777A3 (en) * 2012-03-08 2013-12-19 Ozer Tahir M Silicon fistula plug for intestinal fistulas
US8932325B2 (en) 2010-05-19 2015-01-13 Cook Medical Technologies Llc Devices and methods useful for sealing bodily openings
US8968361B2 (en) 2008-02-15 2015-03-03 Rex Medical, L.P. Vascular hole closure device
US9226738B2 (en) 2008-02-15 2016-01-05 Rex Medical, L.P. Vascular hole closure delivery device
US9277904B2 (en) 2010-05-19 2016-03-08 Cook Medical Technologies Llc Devices and methods useful for sealing bodily openings
US9295458B2 (en) 2008-02-15 2016-03-29 Rex Medical, L.P. Vascular hole closure delivery device
US20160228109A1 (en) * 2015-02-10 2016-08-11 Vascular Solution, Inc. Closure device for sealing percutaneous opening in a vessel
US9463005B2 (en) 2008-02-15 2016-10-11 Rex Medical, L.P. Vascular hole closure device
US9724082B2 (en) 2013-03-15 2017-08-08 Cook Medical Technologies Llc Delivery system for tissue opening closures
US9757113B2 (en) 2013-07-31 2017-09-12 Medos International Sàrl Adjustable graft fixation device
US9782155B2 (en) 2008-02-15 2017-10-10 Rex Medical, L.P. Vascular hole closure device
US9943298B2 (en) 2012-10-19 2018-04-17 Cook Medical Technologies Llc Vascular closure with shape memory characteristic
US9968345B2 (en) 1999-09-13 2018-05-15 Rex Medical, L.P. Vascular hole closure device
US9974643B2 (en) 2013-03-11 2018-05-22 Medos International Sàrl Implant having adjustable filament coils
US10052094B2 (en) 2013-03-11 2018-08-21 Medos International Sàrl Implant having adjustable filament coils
US10070850B2 (en) 2012-10-19 2018-09-11 Cook Medical Technologies Llc Vascular closure with multiple connections
US10154835B2 (en) 2013-05-09 2018-12-18 Essential Medical, Inc. Vascular closure device with conforming plug member

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CA2695872A1 (en) 2009-09-17
EP2173256B1 (en) 2018-01-31
AU2009223926B2 (en) 2013-06-20
US20110029014A1 (en) 2011-02-03
AU2009223926A1 (en) 2009-09-17
WO2009112930A2 (en) 2009-09-17
EP2173256A2 (en) 2010-04-14
WO2009112930A8 (en) 2010-09-10
JP5624895B2 (en) 2014-11-12
JP2011515122A (en) 2011-05-19
US8308762B2 (en) 2012-11-13
WO2009112930A3 (en) 2009-12-03

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