Connect public, paid and private patent data with Google Patents Public Datasets

Method and device for lymphatic system monitoring

Download PDF

Info

Publication number
US20090228059A1
US20090228059A1 US12430211 US43021109A US2009228059A1 US 20090228059 A1 US20090228059 A1 US 20090228059A1 US 12430211 US12430211 US 12430211 US 43021109 A US43021109 A US 43021109A US 2009228059 A1 US2009228059 A1 US 2009228059A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
lymphatic
device
circuitry
sensor
system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12430211
Inventor
Allan C. Shuros
Michael J. Kane
Original Assignee
Shuros Allan C
Kane Michael J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/03Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • A61B5/076Permanent implantations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/365Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031Implanted circuitry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/3627Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

A device and method are disclosed for physiological monitoring of the lymphatic system. An implantable device is configured with a lymphatic sensor disposed in a lymphatic vessel for sensing pressure, flow, and/or the concentration of particular markers within the vessel. The device may be further configured to deliver appropriate therapy in accordance with the lymphatic monitoring.

Description

    CROSS REFERENCE TO RELATED APPLICATIONS
  • [0001]
    This application is a divisional of U.S. application Ser. No. 11/422,417, filed Jun. 6, 2006, which is hereby incorporated by reference in its entirety.
  • [0002]
    This application is related to co-pending application Ser. Nos. 11/422,423, 11/422,414, 11/422,418, and 11/422,421 all filed Jun. 6, 2006 and hereby incorporated by reference.
  • FIELD OF THE INVENTION
  • [0003]
    This invention pertains to methods and systems for diagnosing and treating disease with implantable devices.
  • BACKGROUND
  • [0004]
    The lymphatic system and the cardiovascular system are closely related structures that are joined by a capillary system. The lymphatic system is important to the body's defense mechanisms by filtering out organisms that cause disease and producing lymphocytes that attack foreign organisms and generate antibodies. It is also important for the distribution of fluids and nutrients in the body, because it drains excess fluids and protein from interstitial tissues. Lymph is the fluid that seeps outside the blood vessels in interstitial spaces of body tissues and is then absorbed by lymphatic capillaries to flow back into the bloodstream through the lymphatic vessels. The terminal structures of the lymphatic vessels include the right lymphatic duct, which drains lymph fluid from the upper right quarter of the body above the diaphragm and down the midline, and the thoracic duct, located in the mediastinum of the pleural cavity which drains the rest of the body. Through the flow of blood in and out of arteries, into the veins, and through the lymph vessels and nodes, the body is able to eliminate the products of cellular breakdown and bacterial invasion.
  • SUMMARY
  • [0005]
    A device and method are disclosed for physiological monitoring of the lymphatic system. An implantable device is configured with a lymphatic sensor disposed in a lymphatic vessel for sensing pressure, flow, and/or the concentration of particular markers within the vessel. The device may be further configured to deliver appropriate therapy in accordance with the lymphatic monitoring.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0006]
    FIG. 1 illustrates the physical placement of an implanted monitoring device and attached lead.
  • [0007]
    FIG. 2 illustrates the components of an exemplary system for physiological monitoring of the lymphatic system.
  • [0008]
    FIG. 3 illustrates a block diagram of the components of an exemplary implantable monitoring device.
  • [0009]
    FIG. 4 illustrates an embodiment for delivering cardiac pacing therapy.
  • DETAILED DESCRIPTION
  • [0010]
    This disclosure relates to a device and method for monitoring lymphatic function. The lymphatic vessels are part of the body's circulatory system and serve as a pathway by which fluids can flow from the interstitial spaces into blood. Lymphatic vessels also communicate with lymph nodes and facilitate the body's immune function by transporting foreign antigens to the lymph nodes from the interstitial spaces. As described below, an implantable device may be used to monitor lymphatic function and thereby detect particular conditions such as increased inflammation and edema.
  • [0011]
    One of the functions performed by the lymphatic system is the conveying back to the blood of fluid and proteins exuded from the blood vessels into the interstitial space. Exuded fluid and proteins are absorbed by lymphatic capillaries and then flow into the venous system through lymphatic vessels. The lymphatic system is normally very efficient at removing excess fluid from the interstitial space and is even able to maintain a slight negative pressure. Under certain conditions, however, the lymphatic system is so overwhelmed with fluid that a buildup occurs, referred to as edema. When edema occurs, pressure and flow within the lymphatic vessels increases. As described below, an implantable device may be configured to measure these parameters and detect edema. The concentration of particular molecules in the lymphatic fluid may also be detected by the device in order to further characterize edema or detect other clinical states of interest. The device may also be configured to deliver a specific therapy in response to the monitoring of lymphatic function, such as when edema is detected.
  • [0012]
    In one embodiment, a lymphatic function monitor may be incorporated as part of a cardiac pacing device configured to deliver cardiac resynchronization therapy (CRT) in which pacing pulses are used to overcome conduction deficits and cause the heart to contract in a more coordinated manner (e.g., biventricular pacing). CRT is commonly used to treat patients with chronic heart failure. When chronic heart failure worsens, the decreased cardiac output causes diminished renal perfusion. The kidneys compensate for this by absorbing more salt and water from the renal filtrate which raises venous pressure. The increased venous pressure then results in edema when the fluid buildup into the interstitial space overcomes the lymphatic system's ability to remove it. Edema due to heart failure may occur, for example, in the lung or in the extremities. In one embodiment, an implantable device configured to monitor lymphatic function may be further configured to initiate, increase, or modulate the delivery of CRT when edema is detected. The device could also be programmed to adjust certain CRT parameters such as the atrio-ventricular delay interval when edema is detected.
  • [0013]
    Edema can also be caused by kidney disease or liver disease that results in decreased plasma proteins, particularly albumin. This causes increases osmotic pressure that forces more fluid from the blood capillaries into the interstitium. In another embodiment, the device is configured to deliver an appropriate medication when edema is detected (e.g., an ACE inhibitor or angiotensin receptor blocker for the treatment of kidney disease.)
  • [0014]
    The composition of lymphatic fluid may also be monitored to determine if particular clinical states exist. For example, the concentration of cytokines and immunoglobulins may be used to assess certain autoimmune diseases and cancer. When the concentration of such substances reaches a particular level, the device may then be configured to deliver an appropriate medication.
  • [0015]
    FIG. 1 shows an exemplary physical placement of an implantable monitoring device as described herein. In one embodiment, an implantable monitoring device 105 is placed subcutaneously on the patient's chest or abdomen, similar to a standard cardiac pacemaker. The monitoring device is connected to one or more leads 110, each having a distal member that incorporates an electrode or sensor for sensing physiological parameter(s) related to lymphatic function, referred to herein as a lymphatic sensor. The lead is positioned within the lymphatic system using a venous approach which involves initial entry into the venous blood system. In the embodiment depicted in FIG. 1, the lead 110 passes subcutaneously from the device housing 130 to a point of venous access in the upper chest or neck such as the subclavian vein. The lead is then guided into the thoracic duct ostium using standard fluoroscopy techniques and positioned at a selected location within the lymphatic system. An alternative implantation approach includes placing the lymphatic sensor using a direct surgical approach.
  • [0016]
    FIG. 2 shows an exemplary monitoring system. The pulse monitoring device 105 includes a hermetically sealed housing 130 that is placed subcutaneously or submuscularly in a patient's chest or other convenient location as noted above. The housing 130 may be formed from a conductive metal, such as titanium, and may serve as an electrode for delivering electrical stimulation with a unipolar lead. A header 140, which may be formed of an insulating material, is mounted on the housing 130 for receiving the leads 110 which are electrically connected to the circuitry within the housing. Contained within the housing 130 is the electronic circuitry 132 for providing the functionality to the device as described herein which may include a power supply, monitoring circuitry, therapy circuitry, and a programmable electronic controller for controlling the operation of the device.
  • [0017]
    FIG. 3 illustrates exemplary components of the electronic circuitry 132 depicted in FIG. 2. A controller 135 is provided which may be made up of discrete circuit elements but is preferably a processing element such as a microprocessor together with associated memory for program and data storage which may be programmed to perform algorithms for delivering therapy. (As the terms are used herein, “circuitry” and “controller” may refer either to a programmed processor or to dedicated hardware components configured to perform a particular task.) The controller is interfaced to monitoring circuitry 136 from which it receives data generated by one or more lymphatic sensors 137. The monitoring circuitry may include, for example, circuitry for amplification, filtering, and/or analog-to-digital conversion of voltages generated by a lymphatic sensor.
  • [0018]
    In one embodiment, the lymphatic sensor 137 is a flow or pressure sensor for sensing conditions within a lymphatic vessel that indicate edema may be present. As noted above, edema may be diagnosed when the lymphatic vessels are overwhelmed with fluid due to, for example, elevated venous pressure caused by heart failure and renal compensation thereof, kidney disease, or liver disease. Under such conditions, the pressure and/or flow of lymph within the lymphatic vessels may be increased. In another embodiment, the lymphatic sensor is a chemo-sensor designed to generate a voltage proportional to the concentration of a particular chemical species. The chemo-sensor may be used to provide the controller an indication of the concentration of a particular molecule in the lymphatic fluid that is of interest, referred to as a marker. Examples of markers whose concentrations may be of diagnostic value include immunoglobulins, cytokines, or specific proteins that could be used to characterize a particular disease state. Such chemo-sensors may use immobilized antibodies with binding affinities specific for the different marker antigens. Upon formation of an Ab-Ag complex between the antibody and the marker, the chemo-sensor may produce an electrical signal by, for example, incorporating a piezoelectric transducer that responds to mechanical stresses induced by the Ab-Ag complex or a transducer that responds to potential changes resulting from the Ab-Ag complex.
  • [0019]
    In another embodiment, the lymphatic sensor is a stretch or volume sensor that monitors the degree of stretch or change in volume within a lymphatic vessel using impedance, ultrasonics, acoustic, capacitance, inductance, or optical-type instruments. In another embodiment, the lymphatic sensor is a pulsatile rate sensor using impedance, ultrasonics, acoustic, piezoelectric, piezoresistive, capacitance, inductance, or optical type instruments to monitor pulsatile flow within a lymphatic vessel or a pulsatile contractility sensor that measures intensity of peristaltic wave motion using impedance, ultrasonics, acoustic, capacitance, inductance, or optical type instruments. In another embodiment, the lymphatic sensor is a density sensor for detecting the concentration of dissolved and suspended particulates in the lymph fluid using an optical, acoustic, or electrical instrument. In another embodiment, the lymphatic sensor is a cell counting sensor that detects the density of lymphocytes in the lymph fluid.
  • [0020]
    In the embodiment illustrated in FIG. 3, the controller 135 is also interfaced to therapy circuitry 140 in order to control the delivery of therapy by the device in response to conditions sensed by the monitoring circuitry. The therapy circuitry 135 may include circuitry for delivery of one or more therapy modalities such as cardiac resynchronization therapy, neural stimulation, and drug therapy. In one embodiment, shown in FIG. 4, the device includes circuitry for delivering bradycardia cardiac pacing and/or cardiac resynchronization therapy and includes pulse generation circuitry 140, cardiac sensing circuitry 142, and pacing/sensing electrodes 111 electrically connected to the device by leads (i.e., intravenous leads such as shown in FIG. 1) adapted for disposition in the heart. In another embodiment, the device includes a drug delivery device 145 actuated by the therapy circuitry that may be used to deliver medication in response detection of particular conditions. Such medications could include anti-inflammatory drugs, cancer chemotherapeutic agents, diuretics, or cardiac drugs.
  • [0021]
    Also interfaced to the controller in FIG. 3 is a telemetry transceiver 150 capable of communicating with an external programmer or a remote monitoring device 190 as illustrated in FIG. 2. An external programmer wirelessly communicates with the device 105 and enables a clinician to receive data and modify the programming of the controller. A remote monitoring device similarly communicates with the device 105 and is further interfaced to a network 195 (e.g., an internet connection) for communicating with a patient management server 196 that allows clinical personnel at remote locations to receive data from the remote monitoring device as well as issue commands. The controller may be programmed such when particular conditions are detected by the monitoring circuitry (such as when a measured parameter exceeds or falls below a specified limit value), the device transmits an alarm message to the remote monitoring device and to the patient management server to alert clinical personnel.
  • [0022]
    In order to implant a lead incorporating a lymphatic sensor(s) into a selected location within lymphatic vessel, the lymphatic system may be visualized using lymphangiography. In this technique, dye is injected into the subcutaneous tissue of an extremity such as the foot, or other peripheral lymph vessel, and the lymphatic system drains the dye making the lymphatic vessels visible. A lymphatic vessel is cannulated, and radiopaque contrast is injected to illuminate major lymph vessels including the thoracic duct and its ostium into the subclavian vein. A catheter or the lead may then be guided into the thoracic duct ostium via the venous system using fluoroscopy techniques and positioned at a selected location within the lymphatic system. Initial cannulation of the lymph ostium with a guide wire or catheter may be achieved through the left or right subclavian vein, the left jugular veins, the epigastric/mammary veins or the femoral veins. In order to facilitate navigation through the lymphatic vessels and position the sensor at a selected anatomical location, an overlapping technique may be employed whereby fluoroscopic images produced by the injected dye are used in conjunction with anatomical images of the patient produced by other modalities such as conventional x-ray, CAT scans, MRI scans, or ultrasonic scans. The fluoroscopic image may be overlaid with the anatomical image and the lead then guided to the selected location.
  • [0023]
    To implant the lead, a catheter or the lead by itself may be introduced into the venous system and from there into the thoracic duct ostium using conventional over-the-wire techniques that employ a guide wire. The guide wire is manually or mechanically pushed and manipulated to guide its travel and upon which catheters and/or leads may be advanced. A stereotaxis technique in which external magnets or other means are used to guide the catheter may also be used to improve maneuverability and precision as well as provide increased safety. An example of this technique is described in U.S. Pat. No. 6,475,223, hereby incorporated by reference. Once the catheter or lead is in the lymphatic system, it must also traverse valves in the lymphatic vessels whose function is to allow flow of lymphatic fluid in only one direction to the thoracic duct. In the case where a catheter is employed, as the catheter is guided through a vessel to one of these valves, the catheter may incorporate a vacuum system to open the valves. When the vacuum system is actuated, it draws negative pressure to create a pressure gradient that opens the valve. An alternative technique for opening lymphatic valves involves using a catheter incorporating a compliant balloon on its distal tip. When the catheter reaches a lymphatic valve, the balloon is inflated to mechanically dilate the vessel which opens the valve and allows a wire or the catheter to pass through. In still another technique, the catheter incorporates an electrode at its tip that is used to cause smooth muscle contraction of the lymphatic vessel. Such smooth muscle contraction can create a pressure gradient that opens the valve and allows the catheter to advance past the valve.
  • [0024]
    Although the invention has been described in conjunction with the foregoing specific embodiments, many alternatives, variations, and modifications will be apparent to those of ordinary skill in the art. Such alternatives, variations, and modifications are intended to fall within the scope of the following appended claims.

Claims (12)

1. A device, comprising:
monitoring and therapy circuitry contained within an implantable housing;
a lead electrically connected to the monitoring circuitry that is adapted for implantation into a lymphatic vessel, the lead having a lymphatic sensor incorporated therein for sensing a physiological parameter related to lymphatic function;
a controller interfaced to the therapy circuitry and interfaced to the monitoring circuitry for processing sensing signals generated by the lymphatic sensor;
wherein the controller is programmed to modify the delivery of therapy when edema is detected from the lymphatic sensor signals.
2. The device of claim 1 wherein the lymphatic sensor is a pressure sensor.
3. The device of claim 1 wherein the lymphatic sensor is a flow sensor.
4. The device of claim 1 wherein the lymphatic sensor is a chemo-sensor for generating a voltage proportional to the concentration of a particular chemical species in the lymphatic fluid.
5. The device of claim 1 further comprising a telemetry transceiver interfaced to the controller for enabling wireless communication with the controller.
6. The device of claim 5 wherein the controller is programmed to transmit an alarm message via the telemetry transceiver if a value sensed by the lymphatic sensor reaches a specified limit value.
7. The device of claim 1 wherein the therapy circuitry comprises:
cardiac pacing circuitry, including pulse generation circuitry and cardiac sensing circuitry;
one or more leads with pacing/sensing electrodes electrically connected to the cardiac pacing circuitry; and,
wherein the controller is programmed to deliver bradycardia pacing therapy based upon sensing signals generated by the lymphatic sensor.
8. The device of claim 1 wherein the therapy circuitry comprises:
pulse generation circuitry;
one or more leads with electrodes electrically connected to the pulse generation circuitry for delivering neural stimulation; and,
wherein the controller is programmed to deliver neural stimulation therapy based upon sensing signals generated by the lymphatic sensor.
9. The device of claim 1 wherein the therapy circuitry comprises:
a drug delivery device actuated by the therapy circuitry; and,
wherein the controller is programmed to deliver medication based upon sensing signals generated by the lymphatic sensor.
10. The device of claim 1 wherein the therapy circuitry comprises:
cardiac pacing circuitry, including pulse generation circuitry and cardiac sensing circuitry;
one or more leads with pacing/sensing electrodes electrically connected to the cardiac pacing circuitry; and,
wherein the controller is programmed to deliver cardiac resynchronization therapy based upon sensing signals generated by the lymphatic sensor.
11. The device of claim 10 wherein the controller is programmed to initiate, or increase, the delivery of cardiac resynchronization therapy upon sensing a lymphatic flow or pressure value indicative of edema.
12. The device of claim 10 wherein the controller is programmed to adjust one or more cardiac resynchronization parameters upon sensing a lymphatic flow or pressure value indicative of edema.
US12430211 2006-06-06 2009-04-27 Method and device for lymphatic system monitoring Abandoned US20090228059A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11422417 US7526337B2 (en) 2006-06-06 2006-06-06 Method and device for lymphatic system monitoring
US12430211 US20090228059A1 (en) 2006-06-06 2009-04-27 Method and device for lymphatic system monitoring

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12430211 US20090228059A1 (en) 2006-06-06 2009-04-27 Method and device for lymphatic system monitoring

Publications (1)

Publication Number Publication Date
US20090228059A1 true true US20090228059A1 (en) 2009-09-10

Family

ID=38623969

Family Applications (2)

Application Number Title Priority Date Filing Date
US11422417 Active US7526337B2 (en) 2006-06-06 2006-06-06 Method and device for lymphatic system monitoring
US12430211 Abandoned US20090228059A1 (en) 2006-06-06 2009-04-27 Method and device for lymphatic system monitoring

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US11422417 Active US7526337B2 (en) 2006-06-06 2006-06-06 Method and device for lymphatic system monitoring

Country Status (4)

Country Link
US (2) US7526337B2 (en)
JP (1) JP5235014B2 (en)
EP (1) EP2029003A2 (en)
WO (1) WO2007146489A3 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070282386A1 (en) * 2006-06-06 2007-12-06 Shuros Allan C Method and apparatus for gastrointestinal stimulation via the lymphatic system
US20070282390A1 (en) * 2006-06-06 2007-12-06 Shuros Allan C Amelioration of chronic pain by endolymphatic stimulation
US20080009719A1 (en) * 2006-06-06 2008-01-10 Shuros Allan C Method and apparatus for introducing endolymphatic instrumentation
US20080195171A1 (en) * 2007-02-13 2008-08-14 Sharma Virender K Method and Apparatus for Electrical Stimulation of the Pancreatico-Biliary System
US20110276023A1 (en) * 2010-05-04 2011-11-10 Leeflang Stephen A Apparatus and Methods for Accessing the Lymphatic System
US8369943B2 (en) 2006-06-06 2013-02-05 Cardiac Pacemakers, Inc. Method and apparatus for neural stimulation via the lymphatic system
US8905999B2 (en) 2006-09-01 2014-12-09 Cardiac Pacemakers, Inc. Method and apparatus for endolymphatic drug delivery
WO2015200797A3 (en) * 2014-06-26 2016-02-18 The Trustees Of The University Of Pennsylvania Devices and methods for alleviating lymphatic system congestion

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7526337B2 (en) 2006-06-06 2009-04-28 Cardiac Pacemakers, Inc. Method and device for lymphatic system monitoring
US20080294228A1 (en) * 2007-05-23 2008-11-27 Cardiac Pacemakers Method and device for controlled stimulation of lymphatic flow
US8105261B2 (en) 2007-07-02 2012-01-31 Cardiac Pacemakers, Inc. Osmotic devices and methods for diuretic therapy
WO2010039527A1 (en) * 2008-09-23 2010-04-08 Cardiac Pacemakers, Inc. Method and apparatus for organ specific inflammation monitoring
WO2010080717A1 (en) 2009-01-12 2010-07-15 The Board Of Trustees Of The Leland Stanford Junior University Drainage device and method
EP2416848A1 (en) * 2009-04-07 2012-02-15 Cardiac Pacemakers, Inc. Apparatus for organ-specific inflammation therapy
WO2010137358A1 (en) * 2009-05-29 2010-12-02 国立大学法人浜松医科大学 Lymphatic pressure-measuring system and method for controlling same
WO2014145301A1 (en) * 2013-03-15 2014-09-18 Matthew John Callaghan Apparatus and methods for accessing the lymphatic system

Citations (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3814080A (en) * 1972-11-13 1974-06-04 Becton Dickinson Co Vessel cannulator and clamp for lymphangiography
US3916875A (en) * 1974-01-02 1975-11-04 Herbert Toch Lymph duct cannulation facilitator
US4650467A (en) * 1984-08-22 1987-03-17 Sarcem S.A. Remote control catheter
US4792330A (en) * 1987-07-13 1988-12-20 Lazarus Medical Innovations, Inc. Combination catheter and duct clamp apparatus and method
US4909787A (en) * 1986-08-14 1990-03-20 Danforth John W Controllable flexibility catheter with eccentric stiffener
US4957484A (en) * 1988-07-26 1990-09-18 Automedix Sciences, Inc. Lymph access catheters and methods of administration
US5112303A (en) * 1991-05-02 1992-05-12 Pudenz-Schulte Medical Research Corporation Tumor access device and method for delivering medication into a body cavity
US5284153A (en) * 1992-04-14 1994-02-08 Brigham And Women's Hospital Method for locating a nerve and for protecting nerves from injury during surgery
US5305745A (en) * 1988-06-13 1994-04-26 Fred Zacouto Device for protection against blood-related disorders, notably thromboses, embolisms, vascular spasms, hemorrhages, hemopathies and the presence of abnormal elements in the blood
US5333609A (en) * 1992-05-19 1994-08-02 Minnesota Mining And Manufacturing Company Catheter and probe-catheter assembly
US5387231A (en) * 1992-07-21 1995-02-07 Sporer; Patsy Electrotherapy method
US5391143A (en) * 1993-03-12 1995-02-21 Kensey Nash Corporation Method and system for effecting weight reduction of living beings
US5405363A (en) * 1991-03-15 1995-04-11 Angelon Corporation Implantable cardioverter defibrillator having a smaller displacement volume
US5596988A (en) * 1993-06-30 1997-01-28 Biomedical Sensors, Ltd. Multi-parameter sensor apparatus
US5655548A (en) * 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US5658318A (en) * 1994-06-24 1997-08-19 Pacesetter Ab Method and apparatus for detecting a state of imminent cardiac arrhythmia in response to a nerve signal from the autonomic nerve system to the heart, and for administrating anti-arrhythmia therapy in response thereto
US5662689A (en) * 1995-09-08 1997-09-02 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain
US5697953A (en) * 1993-03-13 1997-12-16 Angeion Corporation Implantable cardioverter defibrillator having a smaller displacement volume
US5817138A (en) * 1996-11-27 1998-10-06 Suzuki; James Y. Multi-channel, interferential wave, micro current device and methods for treatment using micro current
US5865744A (en) * 1996-09-16 1999-02-02 Lemelson; Jerome H. Method and system for delivering therapeutic agents
US5891084A (en) * 1994-12-27 1999-04-06 Lee; Vincent W. Multiple chamber catheter delivery system
US6024704A (en) * 1998-04-30 2000-02-15 Medtronic, Inc Implantable medical device for sensing absolute blood pressure and barometric pressure
US6077227A (en) * 1998-12-28 2000-06-20 Medtronic, Inc. Method for manufacture and implant of an implantable blood vessel cuff
US6106477A (en) * 1998-12-28 2000-08-22 Medtronic, Inc. Chronically implantable blood vessel cuff with sensor
US6115637A (en) * 1998-12-22 2000-09-05 Universities Research Association, Inc. Microcurrent therapeutic technique for treatment of radiation toxicity
US6129685A (en) * 1994-02-09 2000-10-10 The University Of Iowa Research Foundation Stereotactic hypothalamic obesity probe
US6238423B1 (en) * 1997-01-13 2001-05-29 Medtronic, Inc. Apparatus and method for treating chronic constipation
US20010007924A1 (en) * 1999-12-28 2001-07-12 Tanita Corporation Apparatus for detemining degree of restoration of diseased part
US6272370B1 (en) * 1998-08-07 2001-08-07 The Regents Of University Of Minnesota MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging
US6292695B1 (en) * 1998-06-19 2001-09-18 Wilton W. Webster, Jr. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US20010037061A1 (en) * 2000-04-28 2001-11-01 Rolf Eckmiller Microcontact structure for neuroprostheses for implantation on nerve tissue and method therefor
US20010041870A1 (en) * 1999-03-09 2001-11-15 Edward M. Gillis Implantable device for access to a treatment site
US6321109B2 (en) * 1996-02-15 2001-11-20 Biosense, Inc. Catheter based surgery
US20020016615A1 (en) * 1998-05-08 2002-02-07 Dev Nagendu B. Electrically induced vessel vasodilation
US20020029037A1 (en) * 2000-09-06 2002-03-07 Kim Young D. Method and apparatus for percutaneous trans-endocardial reperfusion
US6370417B1 (en) * 1998-09-22 2002-04-09 Siemens Akiengesellschaft Method for positioning a catheter in a vessel, and device for implementing the method
US6368274B1 (en) * 1999-07-01 2002-04-09 Medtronic Minimed, Inc. Reusable analyte sensor site and method of using the same
US20020123674A1 (en) * 2001-03-01 2002-09-05 Gianni Plicchi Process and implantable device for the intrapulmonary assessing of density dependant physical properties of the lung tissue
US20020156462A1 (en) * 2001-04-18 2002-10-24 Stultz Mark R. Programmable implantable pump with accessory reservoirs and multiple independent lumen catheter
US6475223B1 (en) * 1997-08-29 2002-11-05 Stereotaxis, Inc. Method and apparatus for magnetically controlling motion direction of a mechanically pushed catheter
US20020188253A1 (en) * 2001-06-07 2002-12-12 Pharmaspec Corporation Method and apparatus for drug delivery in veins
US20030018247A1 (en) * 2001-06-29 2003-01-23 George Gonzalez Process for testing and treating aberrant sensory afferents and motors efferents
US20030036773A1 (en) * 2001-08-03 2003-02-20 Whitehurst Todd K. Systems and methods for treatment of coronary artery disease
US20030078623A1 (en) * 2001-10-22 2003-04-24 Weinberg Lisa P. Implantable lead and method for stimulating the vagus nerve
US20030105506A1 (en) * 2001-12-04 2003-06-05 Cardiac Pacemakers, Inc. Apparatus and method for stabilizing an implantable lead
US20030113303A1 (en) * 1998-02-05 2003-06-19 Yitzhack Schwartz Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances
US6584362B1 (en) * 2000-08-30 2003-06-24 Cardiac Pacemakers, Inc. Leads for pacing and/or sensing the heart from within the coronary veins
US6629534B1 (en) * 1999-04-09 2003-10-07 Evalve, Inc. Methods and apparatus for cardiac valve repair
US20030204185A1 (en) * 2002-04-26 2003-10-30 Sherman Marshall L. System and method for monitoring use of disposable catheters
US20040006795A1 (en) * 2002-06-13 2004-01-08 Mcgonigle Brian Methods to increase the isoflavonoid levels in plants and plants producing increased levels of isoflavonoids
US6676686B2 (en) * 2000-04-25 2004-01-13 Harumi Naganuma Noninvasive detection and activation of the lymphatic system in treating disease and alleviating pain
US6741882B2 (en) * 1999-12-02 2004-05-25 Koninklijke Philips Electronics N.V. MR device and MR method for localizing and/or visualizing a medical instrument provided with a passive magnet device
US20040102804A1 (en) * 1999-08-10 2004-05-27 Chin Albert K. Apparatus and methods for endoscopic surgical procedures
US20040106953A1 (en) * 2002-10-04 2004-06-03 Yomtov Barry M. Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
US20040158297A1 (en) * 2001-06-29 2004-08-12 George Gonzalez Process for testing and treating motor and muscle function, sensory, autonomic, cognitive and neurologic disorders
US20040172080A1 (en) * 2002-12-04 2004-09-02 Stadler Robert W. Method and apparatus for detecting change in intrathoracic electrical impedance
US20040172102A1 (en) * 2000-04-13 2004-09-02 Cochlear Limited At least partially implantable system for rehabilitation of a hearing disorder
US6804558B2 (en) * 1999-07-07 2004-10-12 Medtronic, Inc. System and method of communicating between an implantable medical device and a remote computer system or health care provider
US20040210118A1 (en) * 2003-04-18 2004-10-21 Michel Letort In situ detection of endoleak and endotension
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US20050043894A1 (en) * 2003-08-22 2005-02-24 Fernandez Dennis S. Integrated biosensor and simulation system for diagnosis and therapy
US20050043675A1 (en) * 2003-08-21 2005-02-24 Pastore Joseph M. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US20050049472A1 (en) * 2003-08-29 2005-03-03 Medtronic, Inc. Implantable biosensor devices for monitoring cardiac marker molecules
US20050075701A1 (en) * 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for attenuating an immune response
US20050075702A1 (en) * 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for inhibiting release of pro-inflammatory mediator
US20050080346A1 (en) * 2002-12-16 2005-04-14 The Regents Of The University Of Michigan Antenna stent device for wireless, intraluminal monitoring
US6893429B2 (en) * 2001-08-30 2005-05-17 Medtronic, Inc. Convection enhanced delivery catheter to treat brain and other tumors
US20050143765A1 (en) * 2002-09-04 2005-06-30 Endoart Sa Telemetrically controlled band for regulating functioning of a body organ or duct, and methods of making, implantation and use
US20050149014A1 (en) * 2001-11-15 2005-07-07 Quantumcor, Inc. Cardiac valve leaflet attachment device and methods thereof
US6918873B1 (en) * 2002-09-19 2005-07-19 Millar Instruments, Inc. Inverted sensor module
US20050187584A1 (en) * 2001-01-16 2005-08-25 Stephen Denker Vagal nerve stimulation using vascular implanted devices for treatment of atrial fibrillation
US20050240243A1 (en) * 2004-02-25 2005-10-27 Giancarlo Barolat System and method for neurological stimulation of peripheral nerves to treat low back pain
US20050246006A1 (en) * 2004-04-30 2005-11-03 Algotec Limited Electrical nerve stimulation device
US20050261741A1 (en) * 2004-05-20 2005-11-24 Imad Libbus Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device
US20050267440A1 (en) * 2004-06-01 2005-12-01 Herman Stephen J Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant
US20060020333A1 (en) * 2004-05-05 2006-01-26 Lashinski Randall T Method of in situ formation of translumenally deployable heart valve support
US20060030837A1 (en) * 2004-01-29 2006-02-09 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US20060074453A1 (en) * 2004-10-04 2006-04-06 Cvrx, Inc. Baroreflex activation and cardiac resychronization for heart failure treatment
US20060149337A1 (en) * 2005-01-21 2006-07-06 John Michael S Systems and methods for tissue stimulation in medical treatment
US20060149331A1 (en) * 2003-12-19 2006-07-06 Brian Mann Method for digital cardiac rhythm management
US7123961B1 (en) * 2002-06-13 2006-10-17 Pacesetter, Inc. Stimulation of autonomic nerves
US20060247601A1 (en) * 2005-04-19 2006-11-02 Ellin Philip J Method of improved drug delivery and for treatment of cellulitis
US20070021731A1 (en) * 1997-11-12 2007-01-25 Garibaldi Jeffrey M Method of and apparatus for navigating medical devices in body lumens
US20070027460A1 (en) * 2005-07-27 2007-02-01 Cook Incorporated Implantable remodelable materials comprising magnetic material
US7277761B2 (en) * 2002-06-12 2007-10-02 Pacesetter, Inc. Vagal stimulation for improving cardiac function in heart failure or CHF patients
US20070255340A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Electrical stimulation of iliohypogastric nerve to alleviate chronic pelvic pain
US20070270675A1 (en) * 2006-05-17 2007-11-22 Michael John Kane Implantable Medical Device with Chemical Sensor and Related Methods
US20080009719A1 (en) * 2006-06-06 2008-01-10 Shuros Allan C Method and apparatus for introducing endolymphatic instrumentation
US20080260861A1 (en) * 2004-04-07 2008-10-23 The General Hospital Corporation Modulating Lymphatic Function
US7526337B2 (en) * 2006-06-06 2009-04-28 Cardiac Pacemakers, Inc. Method and device for lymphatic system monitoring
US20100042170A1 (en) * 2006-06-06 2010-02-18 Shuros Allan C Method and apparatus for neural stimulation via the lymphatic system
US7734341B2 (en) * 2006-06-06 2010-06-08 Cardiac Pacemakers, Inc. Method and apparatus for gastrointestinal stimulation via the lymphatic system
US7774055B1 (en) * 2005-11-07 2010-08-10 Pacesetter, Inc. Left atrial pressure-based criteria for monitoring intrathoracic impedance
US20100227807A1 (en) * 2006-03-15 2010-09-09 The Brigham And Women's Hospital, Inc. Use of Gelsolin to Diagnose and Treat Inflammatory Desease (Stossel)
US20110106202A1 (en) * 2003-12-22 2011-05-05 Jiang Ding Method and system for setting cardiac resynchronization therapy parameters

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2637807B1 (en) * 1988-10-14 1997-10-31 Zacouto Fred Device for protecting against diseases related to the blood, in particular thromboses, embolisms, haemorrhages, hemopathies and presence of abnormal findings in the blood
WO1993014694A1 (en) 1992-01-16 1993-08-05 The General Hospital Corporation Method and apparatus for locating tumors
JP2003327992A (en) * 2002-05-08 2003-11-19 Egredior Kk Essential oil composition and patch
US7195594B2 (en) 2002-05-14 2007-03-27 Pacesetter, Inc. Method for minimally invasive calibration of implanted pressure transducers
US7769427B2 (en) 2002-07-16 2010-08-03 Magnetics, Inc. Apparatus and method for catheter guidance control and imaging
US7134999B2 (en) * 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
US7366572B2 (en) 2004-03-16 2008-04-29 Medtronic, Inc. Controlling therapy based on sleep quality
US20070163353A1 (en) 2005-12-07 2007-07-19 Drexel University Detection of blood pressure and blood pressure waveform
US7894906B2 (en) * 2006-06-06 2011-02-22 Cardiac Pacemakers, Inc. Amelioration of chronic pain by endolymphatic stimulation

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3814080A (en) * 1972-11-13 1974-06-04 Becton Dickinson Co Vessel cannulator and clamp for lymphangiography
US3916875A (en) * 1974-01-02 1975-11-04 Herbert Toch Lymph duct cannulation facilitator
US4650467A (en) * 1984-08-22 1987-03-17 Sarcem S.A. Remote control catheter
US4909787A (en) * 1986-08-14 1990-03-20 Danforth John W Controllable flexibility catheter with eccentric stiffener
US4792330A (en) * 1987-07-13 1988-12-20 Lazarus Medical Innovations, Inc. Combination catheter and duct clamp apparatus and method
US5305745A (en) * 1988-06-13 1994-04-26 Fred Zacouto Device for protection against blood-related disorders, notably thromboses, embolisms, vascular spasms, hemorrhages, hemopathies and the presence of abnormal elements in the blood
US4957484A (en) * 1988-07-26 1990-09-18 Automedix Sciences, Inc. Lymph access catheters and methods of administration
US5405363A (en) * 1991-03-15 1995-04-11 Angelon Corporation Implantable cardioverter defibrillator having a smaller displacement volume
US5112303A (en) * 1991-05-02 1992-05-12 Pudenz-Schulte Medical Research Corporation Tumor access device and method for delivering medication into a body cavity
US5284153A (en) * 1992-04-14 1994-02-08 Brigham And Women's Hospital Method for locating a nerve and for protecting nerves from injury during surgery
US5333609A (en) * 1992-05-19 1994-08-02 Minnesota Mining And Manufacturing Company Catheter and probe-catheter assembly
US5387231A (en) * 1992-07-21 1995-02-07 Sporer; Patsy Electrotherapy method
US5391143A (en) * 1993-03-12 1995-02-21 Kensey Nash Corporation Method and system for effecting weight reduction of living beings
US5697953A (en) * 1993-03-13 1997-12-16 Angeion Corporation Implantable cardioverter defibrillator having a smaller displacement volume
US5596988A (en) * 1993-06-30 1997-01-28 Biomedical Sensors, Ltd. Multi-parameter sensor apparatus
US6129685A (en) * 1994-02-09 2000-10-10 The University Of Iowa Research Foundation Stereotactic hypothalamic obesity probe
US5658318A (en) * 1994-06-24 1997-08-19 Pacesetter Ab Method and apparatus for detecting a state of imminent cardiac arrhythmia in response to a nerve signal from the autonomic nerve system to the heart, and for administrating anti-arrhythmia therapy in response thereto
US5891084A (en) * 1994-12-27 1999-04-06 Lee; Vincent W. Multiple chamber catheter delivery system
US5662689A (en) * 1995-09-08 1997-09-02 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain
US6321109B2 (en) * 1996-02-15 2001-11-20 Biosense, Inc. Catheter based surgery
US5865744A (en) * 1996-09-16 1999-02-02 Lemelson; Jerome H. Method and system for delivering therapeutic agents
US5655548A (en) * 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US5817138A (en) * 1996-11-27 1998-10-06 Suzuki; James Y. Multi-channel, interferential wave, micro current device and methods for treatment using micro current
US6238423B1 (en) * 1997-01-13 2001-05-29 Medtronic, Inc. Apparatus and method for treating chronic constipation
US6475223B1 (en) * 1997-08-29 2002-11-05 Stereotaxis, Inc. Method and apparatus for magnetically controlling motion direction of a mechanically pushed catheter
US20070021731A1 (en) * 1997-11-12 2007-01-25 Garibaldi Jeffrey M Method of and apparatus for navigating medical devices in body lumens
US20030113303A1 (en) * 1998-02-05 2003-06-19 Yitzhack Schwartz Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances
US6024704A (en) * 1998-04-30 2000-02-15 Medtronic, Inc Implantable medical device for sensing absolute blood pressure and barometric pressure
US6347247B1 (en) * 1998-05-08 2002-02-12 Genetronics Inc. Electrically induced vessel vasodilation
US20020016615A1 (en) * 1998-05-08 2002-02-07 Dev Nagendu B. Electrically induced vessel vasodilation
US6292695B1 (en) * 1998-06-19 2001-09-18 Wilton W. Webster, Jr. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US6272370B1 (en) * 1998-08-07 2001-08-07 The Regents Of University Of Minnesota MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging
US6370417B1 (en) * 1998-09-22 2002-04-09 Siemens Akiengesellschaft Method for positioning a catheter in a vessel, and device for implementing the method
US6115637A (en) * 1998-12-22 2000-09-05 Universities Research Association, Inc. Microcurrent therapeutic technique for treatment of radiation toxicity
US6077227A (en) * 1998-12-28 2000-06-20 Medtronic, Inc. Method for manufacture and implant of an implantable blood vessel cuff
US6106477A (en) * 1998-12-28 2000-08-22 Medtronic, Inc. Chronically implantable blood vessel cuff with sensor
US20010041870A1 (en) * 1999-03-09 2001-11-15 Edward M. Gillis Implantable device for access to a treatment site
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US6629534B1 (en) * 1999-04-09 2003-10-07 Evalve, Inc. Methods and apparatus for cardiac valve repair
US6368274B1 (en) * 1999-07-01 2002-04-09 Medtronic Minimed, Inc. Reusable analyte sensor site and method of using the same
US6804558B2 (en) * 1999-07-07 2004-10-12 Medtronic, Inc. System and method of communicating between an implantable medical device and a remote computer system or health care provider
US20040102804A1 (en) * 1999-08-10 2004-05-27 Chin Albert K. Apparatus and methods for endoscopic surgical procedures
US6741882B2 (en) * 1999-12-02 2004-05-25 Koninklijke Philips Electronics N.V. MR device and MR method for localizing and/or visualizing a medical instrument provided with a passive magnet device
US20010007924A1 (en) * 1999-12-28 2001-07-12 Tanita Corporation Apparatus for detemining degree of restoration of diseased part
US20040172102A1 (en) * 2000-04-13 2004-09-02 Cochlear Limited At least partially implantable system for rehabilitation of a hearing disorder
US6676686B2 (en) * 2000-04-25 2004-01-13 Harumi Naganuma Noninvasive detection and activation of the lymphatic system in treating disease and alleviating pain
US20010037061A1 (en) * 2000-04-28 2001-11-01 Rolf Eckmiller Microcontact structure for neuroprostheses for implantation on nerve tissue and method therefor
US6584362B1 (en) * 2000-08-30 2003-06-24 Cardiac Pacemakers, Inc. Leads for pacing and/or sensing the heart from within the coronary veins
US20020029037A1 (en) * 2000-09-06 2002-03-07 Kim Young D. Method and apparatus for percutaneous trans-endocardial reperfusion
US20050187584A1 (en) * 2001-01-16 2005-08-25 Stephen Denker Vagal nerve stimulation using vascular implanted devices for treatment of atrial fibrillation
US20020123674A1 (en) * 2001-03-01 2002-09-05 Gianni Plicchi Process and implantable device for the intrapulmonary assessing of density dependant physical properties of the lung tissue
US20020156462A1 (en) * 2001-04-18 2002-10-24 Stultz Mark R. Programmable implantable pump with accessory reservoirs and multiple independent lumen catheter
US20020188253A1 (en) * 2001-06-07 2002-12-12 Pharmaspec Corporation Method and apparatus for drug delivery in veins
US20040158297A1 (en) * 2001-06-29 2004-08-12 George Gonzalez Process for testing and treating motor and muscle function, sensory, autonomic, cognitive and neurologic disorders
US20030018247A1 (en) * 2001-06-29 2003-01-23 George Gonzalez Process for testing and treating aberrant sensory afferents and motors efferents
US20030036773A1 (en) * 2001-08-03 2003-02-20 Whitehurst Todd K. Systems and methods for treatment of coronary artery disease
US6893429B2 (en) * 2001-08-30 2005-05-17 Medtronic, Inc. Convection enhanced delivery catheter to treat brain and other tumors
US20030078623A1 (en) * 2001-10-22 2003-04-24 Weinberg Lisa P. Implantable lead and method for stimulating the vagus nerve
US20050149014A1 (en) * 2001-11-15 2005-07-07 Quantumcor, Inc. Cardiac valve leaflet attachment device and methods thereof
US20030105506A1 (en) * 2001-12-04 2003-06-05 Cardiac Pacemakers, Inc. Apparatus and method for stabilizing an implantable lead
US20030204185A1 (en) * 2002-04-26 2003-10-30 Sherman Marshall L. System and method for monitoring use of disposable catheters
US7277761B2 (en) * 2002-06-12 2007-10-02 Pacesetter, Inc. Vagal stimulation for improving cardiac function in heart failure or CHF patients
US7123961B1 (en) * 2002-06-13 2006-10-17 Pacesetter, Inc. Stimulation of autonomic nerves
US20040006795A1 (en) * 2002-06-13 2004-01-08 Mcgonigle Brian Methods to increase the isoflavonoid levels in plants and plants producing increased levels of isoflavonoids
US20050143765A1 (en) * 2002-09-04 2005-06-30 Endoart Sa Telemetrically controlled band for regulating functioning of a body organ or duct, and methods of making, implantation and use
US6918873B1 (en) * 2002-09-19 2005-07-19 Millar Instruments, Inc. Inverted sensor module
US20040106953A1 (en) * 2002-10-04 2004-06-03 Yomtov Barry M. Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
US20040172080A1 (en) * 2002-12-04 2004-09-02 Stadler Robert W. Method and apparatus for detecting change in intrathoracic electrical impedance
US20050080346A1 (en) * 2002-12-16 2005-04-14 The Regents Of The University Of Michigan Antenna stent device for wireless, intraluminal monitoring
US20040210118A1 (en) * 2003-04-18 2004-10-21 Michel Letort In situ detection of endoleak and endotension
US20050043675A1 (en) * 2003-08-21 2005-02-24 Pastore Joseph M. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US20050043894A1 (en) * 2003-08-22 2005-02-24 Fernandez Dennis S. Integrated biosensor and simulation system for diagnosis and therapy
US20050049472A1 (en) * 2003-08-29 2005-03-03 Medtronic, Inc. Implantable biosensor devices for monitoring cardiac marker molecules
US20050075702A1 (en) * 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for inhibiting release of pro-inflammatory mediator
US20050075701A1 (en) * 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for attenuating an immune response
US7616991B2 (en) * 2003-12-19 2009-11-10 Pacesetter, Inc. Method for digital cardiac rhythm management
US20060149331A1 (en) * 2003-12-19 2006-07-06 Brian Mann Method for digital cardiac rhythm management
US20110106202A1 (en) * 2003-12-22 2011-05-05 Jiang Ding Method and system for setting cardiac resynchronization therapy parameters
US20060030837A1 (en) * 2004-01-29 2006-02-09 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US20050240243A1 (en) * 2004-02-25 2005-10-27 Giancarlo Barolat System and method for neurological stimulation of peripheral nerves to treat low back pain
US20080260861A1 (en) * 2004-04-07 2008-10-23 The General Hospital Corporation Modulating Lymphatic Function
US20050246006A1 (en) * 2004-04-30 2005-11-03 Algotec Limited Electrical nerve stimulation device
US20060020333A1 (en) * 2004-05-05 2006-01-26 Lashinski Randall T Method of in situ formation of translumenally deployable heart valve support
US20050261741A1 (en) * 2004-05-20 2005-11-24 Imad Libbus Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device
US7260431B2 (en) * 2004-05-20 2007-08-21 Cardiac Pacemakers, Inc. Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device
US20050267440A1 (en) * 2004-06-01 2005-12-01 Herman Stephen J Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant
US20060074453A1 (en) * 2004-10-04 2006-04-06 Cvrx, Inc. Baroreflex activation and cardiac resychronization for heart failure treatment
US20060149337A1 (en) * 2005-01-21 2006-07-06 John Michael S Systems and methods for tissue stimulation in medical treatment
US20060247601A1 (en) * 2005-04-19 2006-11-02 Ellin Philip J Method of improved drug delivery and for treatment of cellulitis
US20070027460A1 (en) * 2005-07-27 2007-02-01 Cook Incorporated Implantable remodelable materials comprising magnetic material
US7774055B1 (en) * 2005-11-07 2010-08-10 Pacesetter, Inc. Left atrial pressure-based criteria for monitoring intrathoracic impedance
US20100227807A1 (en) * 2006-03-15 2010-09-09 The Brigham And Women's Hospital, Inc. Use of Gelsolin to Diagnose and Treat Inflammatory Desease (Stossel)
US20070255340A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Electrical stimulation of iliohypogastric nerve to alleviate chronic pelvic pain
US20070270675A1 (en) * 2006-05-17 2007-11-22 Michael John Kane Implantable Medical Device with Chemical Sensor and Related Methods
US7734341B2 (en) * 2006-06-06 2010-06-08 Cardiac Pacemakers, Inc. Method and apparatus for gastrointestinal stimulation via the lymphatic system
US20100042170A1 (en) * 2006-06-06 2010-02-18 Shuros Allan C Method and apparatus for neural stimulation via the lymphatic system
US20100217346A1 (en) * 2006-06-06 2010-08-26 Shuros Allan C Method and apparatus for gastrointestinal stimulation via the lymphatic system
US7526337B2 (en) * 2006-06-06 2009-04-28 Cardiac Pacemakers, Inc. Method and device for lymphatic system monitoring
US20080009719A1 (en) * 2006-06-06 2008-01-10 Shuros Allan C Method and apparatus for introducing endolymphatic instrumentation

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8126538B2 (en) 2006-06-06 2012-02-28 Cardiac Pacemakers, Inc. Method and apparatus for introducing endolymphatic instrumentation
US20070282390A1 (en) * 2006-06-06 2007-12-06 Shuros Allan C Amelioration of chronic pain by endolymphatic stimulation
US20080009719A1 (en) * 2006-06-06 2008-01-10 Shuros Allan C Method and apparatus for introducing endolymphatic instrumentation
US8897878B2 (en) 2006-06-06 2014-11-25 Cardiac Pacemakers, Inc. Method and apparatus for gastrointestinal stimulation via the lymphatic system
US7734341B2 (en) 2006-06-06 2010-06-08 Cardiac Pacemakers, Inc. Method and apparatus for gastrointestinal stimulation via the lymphatic system
US7894906B2 (en) 2006-06-06 2011-02-22 Cardiac Pacemakers, Inc. Amelioration of chronic pain by endolymphatic stimulation
US8369943B2 (en) 2006-06-06 2013-02-05 Cardiac Pacemakers, Inc. Method and apparatus for neural stimulation via the lymphatic system
US20070282386A1 (en) * 2006-06-06 2007-12-06 Shuros Allan C Method and apparatus for gastrointestinal stimulation via the lymphatic system
US8905999B2 (en) 2006-09-01 2014-12-09 Cardiac Pacemakers, Inc. Method and apparatus for endolymphatic drug delivery
US20080195171A1 (en) * 2007-02-13 2008-08-14 Sharma Virender K Method and Apparatus for Electrical Stimulation of the Pancreatico-Biliary System
US9037244B2 (en) 2007-02-13 2015-05-19 Virender K. Sharma Method and apparatus for electrical stimulation of the pancreatico-biliary system
US20110276023A1 (en) * 2010-05-04 2011-11-10 Leeflang Stephen A Apparatus and Methods for Accessing the Lymphatic System
US9421316B2 (en) * 2010-05-04 2016-08-23 Stephen A. Leeflang Apparatus and methods for accessing the lymphatic system
WO2015200797A3 (en) * 2014-06-26 2016-02-18 The Trustees Of The University Of Pennsylvania Devices and methods for alleviating lymphatic system congestion

Also Published As

Publication number Publication date Type
JP2009539488A (en) 2009-11-19 application
JP5235014B2 (en) 2013-07-10 grant
US20070282382A1 (en) 2007-12-06 application
EP2029003A2 (en) 2009-03-04 application
WO2007146489A3 (en) 2008-02-14 application
US7526337B2 (en) 2009-04-28 grant
WO2007146489A2 (en) 2007-12-21 application

Similar Documents

Publication Publication Date Title
US7335161B2 (en) Techniques for blood pressure measurement by implantable device
US7347843B2 (en) Vascular access port with needle detector
US7206637B2 (en) Cardiac pacing using sensed coronary vein blood temperature and left ventricular flow rate
US6501983B1 (en) Implantable myocardial ischemia detection, indication and action technology
US7024244B2 (en) Estimation of stroke volume cardiac output using an intracardiac pressure sensor
US6033366A (en) Pressure measurement device
US7184835B2 (en) Method and apparatus for adjustable AVD programming using a table
US5188106A (en) Method and apparatus for chronically monitoring the hemodynamic state of a patient using doppler ultrasound
US20080082001A1 (en) Physiological response to posture change
US6937899B2 (en) Ischemia detection
US20050004476A1 (en) Method and apparatus for detecting ischemia
US5454838A (en) Method and a device for monitoring heart function
US5156154A (en) Monitoring the hemodynamic state of a patient from measurements of myocardial contractility using doppler ultrasound techniques
US7181268B2 (en) Ischemia detection
US20050283197A1 (en) Systems and methods for hypotension
US6309350B1 (en) Pressure/temperature/monitor device for heart implantation
US7340296B2 (en) Detection of pleural effusion using transthoracic impedance
US20060247685A1 (en) System and method for detecting hypoglycemia based on a paced depolarization integral using an implantable medical device
US20050137626A1 (en) Drug delivery system and method employing external drug delivery device in conjunction with computer network
US20060271119A1 (en) Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods
US5651767A (en) Replaceable catheter system for physiological sensors, stimulating electrodes and/or implantable fluid delivery systems
US20080114219A1 (en) Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device
US6473640B1 (en) Implantable device and method for long-term detection and monitoring of congestive heart failure
US7387610B2 (en) Thoracic impedance detection with blood resistivity compensation
US20060258952A1 (en) Enhancements to the detection of pulmonary edema when using transthoracic impedance