US20090118170A1 - Buccal, polar and non-polar spray or capsule - Google Patents

Buccal, polar and non-polar spray or capsule Download PDF

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US20090118170A1
US20090118170A1 US12/350,898 US35089809A US2009118170A1 US 20090118170 A1 US20090118170 A1 US 20090118170A1 US 35089809 A US35089809 A US 35089809A US 2009118170 A1 US2009118170 A1 US 2009118170A1
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active compound
amount
composition
weight
polar
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US12/350,898
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Harry A. Dugger, III
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Dugger Iii Harry A
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Priority to PCT/US1997/017899 priority Critical patent/WO1999016417A1/en
Priority to US53711800A priority
Priority to US10/100,156 priority patent/US6676931B2/en
Priority to US10/663,817 priority patent/US20040062716A1/en
Application filed by Dugger Iii Harry A filed Critical Dugger Iii Harry A
Priority to US12/350,898 priority patent/US20090118170A1/en
Publication of US20090118170A1 publication Critical patent/US20090118170A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/4211,3-Oxazoles, e.g. pemoline, trimethadione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • A61K9/124Aerosols; Foams characterised by the propellant

Abstract

Buccal aerosol sprays or capsule using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprises formulation I: polar solvent 37-98.58%, active compound 0.005-55%, optionally containing flavoring agent 0.1-10%.

Description

    RELATED APPLICATIONS
  • This application is a continuation in part of applicant PCT application PCT/US97/17899 filed Oct. 1, 1997.
  • BACKGROUND OF THE INVENTION
  • It is known that certain biologically active compounds are better absorbed through the oral mucosa than through other routes of administration, such as through the stomach or intestine. However, formulations suitable for such administration by these latter routes present their own problems. For example, the biologically active compound must be compatible with the other components of the composition such as propellants, solvents, etc. Many such formulations have been proposed. For example, U.S. Pat. No. 4,689,233, Dvorsky et al., describes a soft gelatin capsule for the administration of the anti-coronary drug nifedipine dissolved in a mixture of polyether alcohols. U.S. Pat. No. 4,755,389, Jones et al., describes a hard gelatin chewable capsule containing nifedipine. A chewable gelatin capsule containing a solution or dispersion of a drug is described in U.S. Pat. No. 4,935,243, Borkan et al. U.S. Pat. No. 4,919,919, Aouda et al, and U.S. Pat. No. 5,370,862, Klokkers-Bethke, describe a nitroglycerin spray for administration to the oral mucosa comprising nitroglycerin, ethanol, and other components. An orally administered pump spray is described by Cholcha in U.S. Pat. No. 5,186,925. Aerosol compositions containing a hydrocarbon propellant and a drug for administration to a mucosal surface are described in U.K. 2,082,457, Su, U.S. Pat. No. 3,155,574, Silson et al., U.S. Pat. No. 5,011,678, Wang et al., and by Parnell in U.S. Pat. No. 5,128,132. It should be noted that these references discuss bioavailability of solutions by inhalation rather than through the membranes to which they are administered.
  • SUMMARY OF THE INVENTION
  • A buccal aerosol spray or soft bite gelatin capsule using a polar or non-polar solvent has now been developed which provides biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect.
  • The buccal aerosol spray compositions of the present invention, for transmucosal administration of a pharmacologically active compound soluble in a pharmacologically acceptable non-polar solvent comprise in weight % of total composition: pharmaceutically acceptable propellant 5-80%, non-polar solvent 20-85%, active compound 0.05-50%, suitably additionally comprising, by weight of total composition a flavoring agent 0.01-10%. Preferably the composition comprises: propellant 10-85%, non-polar solvent 25-89.9%, active compound 0.01-40%, flavoring agent 1-8%; most suitably propellant 20-70%, non-polar solvent 30-74.75%, active compound 0.25-35%, flavoring agent 2-7.5%.
  • The buccal polar aerosol spray compositions of the present invention, for transmucosal administration of a pharmacologically active compound soluble in a pharmacologically acceptable polar solvent are also administrable in aerosol form driven by a propellant. In this case the composition comprise in weight % of total composition: aqueous polar solvent 10-99%, active compound 0.1-25%, suitably additionally comprising, by weight of total composition a flavoring agent 0.05-10% and propellant: 2-10%. Preferably the composition comprises: polar solvent 20-97%, active compound 0.1-15%, flavoring agent 0.1-5% and propellant: 3-5%; most suitably polar solvent 25-97%, active compound 0.2-25%, flavoring agent 0.1-2.5% and propellant: 3-4%.
  • The buccal pump spray composition of the present invention for transmucosal administration of a pharmacologically active compound where said active compound is soluble in a pharmacologically acceptable non-polar solvent said composition comprise in weight % of total composition: non-polar solvent 30-99.69%, active compound 0.005-55%, and suitably additionally, flavoring agent 0.1-10%.
  • The buccal polar pump spray compositions of the present invention, for transmucosal administration of a pharmacologically active compound soluble in a pharmacologically acceptable polar solvent comprising in weight % of total composition: aqueous polar solvent 30-99.69%, active compound 0.001-60%, suitably additionally comprising, by weight of total composition a flavoring agent 0.1-10%. Preferably the composition comprises: polar solvent 37-98.58%, active compound 0.005-55%, flavoring agent 0.5-8%; most suitably polar solvent 60.9-97.06%, active compound 0.01-40%, flavoring agent 0.75-7.5%.
  • The soft bite gelatin capsules of the present invention for transmucosal administration of a pharmacologically active compound, at least partially soluble in a pharmacologically acceptable non-polar solvent, having charged thereto a fill composition comprise in weight % of total composition: non-polar solvent 4-99.99%, emulsifier 0-20%, active compound 0.01-80%, provided that said fill composition contains less than 10% of water, suitably additionally comprising, by weight of the composition: flavoring agent 0.01-10%. Preferably, the soft bite gelatin capsule comprises: non-polar solvent 21.5-99.975%, emulsifier 0-15%, active compound 0.025-70%, flavoring agent 1-8%; most suitably: non-polar solvent 28.5-97.9%, emulsifier 0-10%, active compound 0.1-65.0%, flavoring agent 2-6%.
  • The soft bite polar gelatin capsules of the present invention for transmucosal administration of a pharmacologically active compound, at least partially soluble in a pharmacologically acceptable polar solvent, having charged thereto a composition comprising in weight % of total composition: polar solvent 25-99.89%, emulsifier 0-20%, active compound 0.01-65%, provided that said composition contains less than 10% of water, suitably additionally comprising, by weight of the composition: flavoring agent 01-10%. Preferably, the soft bite gelatin capsule comprises: polar solvent 37-99.95%, emulsifier 0-15%, active compound 0.025-55%, flavoring agent 1-8%; most suitably: polar solvent 44-96.925%, emulsifier 0-10%, active compound 0.075-50%, flavoring agent 2-6%.
  • It is an object of the invention to coat the mucosal membranes either with extremely fine droplets of spray containing the active compounds or a solution or paste thereof from bite capsules.
  • It is also an object of the invention to administer to the oral mucosa of a mammalian in need of same, preferably man, by spray or bite capsule, a predetermined amount of a biologically active compound by this method or from a soft gelatin bite capsule.
  • A further object is a sealed aerosol spray container containing a composition of the non polar or polar aerosol spray formulation, and a metered valve suitable for releasing from said container a predetermined amount of said composition.
  • As the propellant evaporates after activation of the aerosol valve, a mist of fine droplets is formed which contains solvent and active compound.
  • The propellant is a non-Freon material, preferably a C3-8 hydrocarbon of a linear or branched configuration. The propellant should be substantially non-aqueous. The propellant produces a pressure in the aerosol container such that under expected normal usage it will produce sufficient pressure to expel the solvent from the container when the valve is activated but not excessive pressure such as to damage the container or valve seals.
  • The non-polar solvent is a non-polar hydrocarbon, preferably a C7-18 hydrocarbon of a linear or branched configuration, fatty acid esters, and triglycerides, such as miglyol. The solvent must dissolve the active compound and be miscible with the propellant, i.e., solvent and propellant must form a single phase at 0-40° C. at a pressure range of 1-3 atm.
  • The polar and non-polar aerosol spray compositions of the invention are intended to be administered from a sealed, pressurized container. Unlike a pump spray, which allows the entry of air into the container after every activation, the aerosol container of the invention is sealed at the time of manufacture. The contents of the container are released by activation of a metered valve, will does not allow entry of atmospheric gasses with each activation. Such containers are commercially available.
  • A further object is a pump spray container containing a composition of the pump spray formulation, and a metered valve suitable for releasing from said container a predetermined amount of said composition.
  • A further object is a soft gelatin bite capsule containing a composition of as set forth above. The formulation may be in the form of a viscous solution or paste containing the active compounds. Although solutions are preferred, paste fills may also be used where the active compound is not soluble or only partially soluble in the solvent of choice. Where water is used to form part of the paste composition, it should not exceed 10% thereof. (All percentages herein are by weight unless otherwise indicated.)
  • The polar or non-polar solvent is chosen such that it is compatible with the gelatin shell and the active compound. The solvent preferably dissolves the active compound. However, other components wherein the active compound is not soluble or only slightly soluble may be used and will form a paste fill.
  • Soft gelatin capsules are well known in the art. See, for example, U.S. Pat. No. 4,935,243, Borkan et al., for its teaching of such capsules. The capsules of the present invention are intended to be bitten into to release the low viscosity solution or paste therein, which will then coat the buccal mucosa with the active compounds. Typical capsules, which are swallowed whole or bitten and then swallowed, deliver the active compounds the stomach, which results in significant lag time before maximum blood levels can be achieved or subject the compound to a large first pass effect. Because of the enhanced absorption of the compounds through the oral mucosa and no chance of a first pass effect, use of the bite capsules of the invention will eliminate much of the lag time, resulting in hastened onset of biological effect. The shell of a soft gelatin capsule of the invention may comprise, for example:
  • Gelatin: 50-75%, glycerin 20-30%, colorants 0.5-1.5%, water 5-10%, and sorbitol 2-10%.
  • The active compound may include biologically active peptides, central nervous system active amines, sulfonyl ureas, antibiotics, antifungals, anti-virals, sleep inducers, antiasthmatics, bronchial dilators, antiemetics, histamine H-2 receptor antagonists, barbiturates, prostaglandins and neutraceuticals.
  • The active compounds may also include antihistamines, alkaloids, hormones, benzodiazepines and narcotic analgesics. While not limited thereto, these active compounds are particularly suitable for non-polar pump spray formulation and application.
  • BRIEF DESCRIPTION OF THE DRAWING
  • The FIGURE is a schematic diagram showing routes of absorption and processing of pharmacologically active substances in a mammalian system.
  • DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The preferred active compounds of the present invention are in an ionized, salt form or as the free base of the pharmaceutically acceptable salts thereof (provided, for the aerosol or spray compositions, they are soluble in the spray solvent). These compounds are soluble in the non-polar solvents of the invention at useful concentrations or can be prepared as pastes at useful concentrations. These concentrations may be less than the standard accepted dose for these compounds since there is enhanced absorption of the compounds through the oral mucosa. This aspect of the invention is especially important when there is a large (40-99.99%) First pass effect.
  • As propellants for the non polar sprays, propane, N-butane, iso-butane, N-pentane, iso-pentane, and neo-pentane, and mixtures thereof may be used. N-butane and iso-butane, as single gases, are the preferred propellants. It is permissible for the propellant to have a water content of no more than 0.2%, typically 0.1-0.2%. (All percentages herein are by weight unless otherwise indicated.) It is also preferable that the propellant be synthetically produced to minimize the presence of contaminants which are harmful to the active compounds. These contaminants include oxidizing agents, reducing agents, Lewis acids or bases, and water. The concentration of each of these should be less than 0.1%, except that water may be as high as 0.2%.
  • Suitable non-polar solvents for the capsules and the non-polar sprays include (C2-C24) fatty acid C2-C6 esters, C7-C18 hydrocarbon, C2-C6 alkanoyl esters, and the triglycerides of the corresponding acids. When the capsule fill is a paste, other liquid components may be used instead of the above low molecular weight solvents. These include soya oil, corn oil, other vegetable oils.
  • As solvents for the polar capsules or sprays there may be used low molecular weight polyethyleneglycols (PEG) of 400-1000 Mw (preferably 400-600), low molecular weight (C2-C8) mono and polyols and alcohols of C7-C18 linear or branch chain hydrocarbons, glycerin may also be present and water may also be used in the sprays, but only in limited amount in the capsules.
  • It is expected that some glycerin and water used to make the gelatin shell will migrate from the shell to the fill during the curing of the shell. Likewise, there may be some migration of components from the fill to the shell during curing and even throughout the shelf-life of the capsule. Therefore, the values given herein are for the compositions as prepared, it being within the scope of the invention that minor variations will occur.
  • The preferred flavoring agents are synthetic or natural oil of pepper-mint, oil of spearmint, citrus oil, fruit flavors, sweeteners (sugars, aspartame, saccharin, etc.), and combinations thereof.
  • The active substances include the active compounds selected from the group consisting of cyclosporine, sermorelin, Octreotide acetate, calcitonin-salmon, insulin lispro, sumatriptan succinate, clozepine, cyclobenzaprine, dexfenfluramine hydrochloride, glyburide, zidovudine, erythromycin, ciprofloxacin, ondansetron hydrochloride, dimenhydrinate, cimetidine hydrochloride, famotidine, phenyloin sodium, phenyloin, carboprost thromethamine, carboprost, diphenhydramine hydrochloride, isoproterenol hydrochloride, terbutaline sulfate, terbutaline, theophylline, albuterol sulfate and neutraceuticals, that is to say nutrients with pharmacological action such as but not limited to carnitine, valerian, echinacea, and the like.
  • The formulations of the present invention comprise an active compound or a pharmaceutically acceptable salt thereof. The term “pharmaceutically acceptable salts” refers to salts prepared from pharmaceutically acceptable non-toxic acids or bases including organic and inorganic acids or bases.
  • When an active compound of the present invention is acidic, salts may be prepared from pharmaceutically acceptable non-toxic bases. Salts derived from all stable forms of inorganic bases include aluminum, ammonium, calcium, copper, iron, lithium, magnesium, manganese, potassium, sodium, zinc, etc. Particularly preferred are the ammonium, calcium, magnesium, potassium, and sodium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion-exchange resins such as arginine, betaine, caffeine, choline, N,N′-dibenzylethylenediamine, diethylamine, 2-diethylaminoethanol, 2-dimethylaminoethanol, ethanolamine, ethylenediamine, N-ethylmorpholine, N-ethylpiperidine, glucamine, glucosamine, histidine, isopropylamine, lysine, methyl-glucosamine, morpholine, piperazine, piperidine, polyamine resins, procaine, purine, theobromine, triethylamine, trimethylamine, tripropylamine, etc.
  • When an active compound of the present invention is basic, salts may be prepared from pharmaceutically acceptable non-toxic acids. Such acids include acetic, benzenesulfonic, benzoic, camphorsulfonic, citric, ethane-sulfonic, fumaric, gluconic, glutamic, hydrobromic, hydrochloric, isethionic, lactic, maleic, mandelic, methanesulfonic, mucic, nitric, pamoic, pantothenic, phosphoric, succinic, sulfuric, tartaric, p-toluenesulfonic, etc. Particularly preferred are citric, hydrobromic, maleic, phosphoric, sulfuric, and tartaric acids.
  • In the discussion of methods of treatment herein, reference to the active compounds is meant to also include the pharmaceutically acceptable salts thereof. While certain formulations are set forth herein, the actual amounts to be administered to the mammal or man in need of same are to be determined by the treating physician.
  • The invention is further defined by reference to the following examples, which are intended to be illustrative and not limiting.
  • The following are examples of each class (all values unless otherwise specified are in weight percent):
  • EXAMPLE 1 Biologically Active Peptides Including Peptide Hormones
  • A. Cyclosporine lingual spray
    most preferred
    Amounts preferred amount amount
    Cyclosporine 5-50 10-35 15-25
    water 5-20 7.5-50  9.5-12 
    ethanol 5-60 7.5-50  10-20
    polyethylene glycol 20-60  30-45 35-40
    flavors 0.1-5   1-4 2-3
  • B. Cyclosporine Non-Polar lingual spray
    most preferred
    Amounts preferred amount amount
    Cyclosporine  1-50  3-40  5-30
    Migylol 20 25 30-40
    Polyoxyethylated 20 25 30-40
    castor oil
    Butane 25-80 30-70 33-50
    flavors 0.1-5   1-4 2-3
  • C. Cyclosporine non-polar bite capsule
    most preferred
    Amounts preferred amount amount
    Cyclosporine  1-35  5-25 10-20
    olive oil 25-60 35-55 30-45
    polyoxyethylated 25-60 35-55 30-45
    oleic glycerides
    flavors 0.1-5   1-4 2-3
  • D. Cyclosporine bite capsule
    most preferred
    Amounts preferred amount amount
    Cyclosporine 5-50 10-35 15-25
    polyethylene glycol 20-60  30-45 35-40
    glycerin 5-30 7.5-25  10-20
    propylene glycol 5-30 7.5-25  10-20
    flavors 0.1-10   1-8 3-6
  • E. Sermorelin (as the acetate) lingual spray
    Amounts preferred amount most preferred
    sermorelin (as the .01-5   .1-3   .2-1.0
    acetate)
    mannitol, 1-25  5-20 10-15
    monobasic sodium 0.1-5   1-3 1.5-2.5
    phosphate,
    dibasic sodium 0.01-5    .05-3   0.1-0.5
    phosphate water
    ethanol 5-30 7.5-25  9.5-15 
    polyethylene glycol 20-60  30-45 35-40
    propylene glycol 5-25 10-20 12-17
    flavors 0.1-5   1-4 2-3
  • F. Octreotide acetate (Sandostatin*) lingual spray
    most preferred
    Amounts preferred amount amount
    octreotide acetate 0.001-0.5   0.005-0.250 0.01-0.10
    acetic acid 1-10 2-8 4-6
    sodium acetate 1-10 2-8 4-6
    sodium chloride 3-30  5-25 15-20
    flavors 0.1-5   0.5-.4  2-3
    ethanol 5-30 7.5-20  9.5-15 
    water 15-95  35-90 65-85
    flavors 0.1-5   1-4 2-3
  • G. Calcitonin-salmon lingual spray
    most preferred
    Amounts preferred amount amount
    Calcitonin-salmon 0.001-5    0.005-2    01-1.5 
    ethanol 2-15 3-10 7-9.5
    water 30-95  50-90  60-80  
    polyethylene glycol 2-15 3-10 7-9.5
    sodium chloride 2.5-20   5-15 10-12.5
    flavors 0.1-5   1-4  2-3  
  • H. insulin lispro, lingual spray
    most preferred
    Amounts preferred amount amount
    insulin, 20-60   4-55  5-50
    glycerin, 0.1-10   0.25-5   0.1-1.5
    dibasic sodium 1-15 2.5-10  4-8
    phosphate,
    m-cresol, 1-25  5-25  7.5-12.5
    zinc oxide 0.01-0.25   .05-0.15 0.075-0.10 
    m-cresol, 0.1-1   0.2-0.8 0.4-0.6
    phenol trace amounts trace amounts trace amounts
    ethanol 5-20 7.5-15   9-12
    water 30-90  40-80 50-75
    propylene glycol 5-20 7.5-15   9-12
    flavors 0.1-5   0.5-3   0.75-2  
    adjust pH to 7.0-7.8 with HCl or NaOH
  • EXAMPLE 2 CNS Active Amines and their Salts: Including but not Limited to Tricyclic Amines, GABA Analogues, Thiazides, Phenothiazine Derivatives, Serotonin Antagonists and Serotonin Reuptake Inhibitors
  • A. Sumatriptan succinate lingual spray
    most preferred
    Amounts preferred amount amount
    sumatriptan succinate 0.5-30     1-20 10-15
    ethanol 5-60 7.5-50 10-20
    propylene glycol 5-30 7.5-20 10-15
    polyethylene glycol 0-60  30-45 35-40
    water 5-30 7.5-20 10-15
    flavors 0.1-5    1-4 2-3
  • B. Sumatriptan succinate bite capsule
    most preferred
    Amounts preferred amount amount
    sumatriptan succinate 0.01-5   0.05-3.5  0.075-1.75 
    polyethylene glycol 25-70 30-60 35-50
    glycerin 25-70 30-60 35-50
    flavors 0.1-10  1-8 3-6
  • C. Clozepine lingual spray
    most preferred
    Amounts preferred amount amount
    Clozepine 0.5-30     1-20 10-15
    ethanol 5-60 7.5-50 10-20
    propylene glycol 5-30 7.5-20 10-15
    polyethylene glycol 0-60  30-45 35-40
    water 5-30 7.5-20 10-15
    flavors 0.1-5    1-4 2-3
  • D. Clozepine Non-Polar lingual spray with propellant
    most preferred
    Amounts preferred amount amount
    Clozepine 0.5-30   1-20 10-15
    Migylol 20-85 25-70 30-40
    Butane 15-80 30-75 60-70
    flavors 0.1-5   1-4 2-3
  • E. Clozepine Non-Polar lingual spray without propellant
    most preferred
    Amounts preferred amount amount
    Clozepine 0.5-30  1-20 10-15
    Migylol  70-99.5 80-99 85-90
    flavors 0.1-5  1-4 2-3
  • F. Cyclobenzaprine Non-polar lingual spray
    most preferred
    Amounts preferred amount amount
    Cyclobenzaprine 0.5-30   1-20 10-15
    (base)
    Migylol 20-85 25-70 30-40
    Isobutane 15-80 30-75 60-70
    flavors 0.1-5   1-4 2-3
  • G. dexfenfluramine hydrochloride lingual spray
    most preferred
    Amounts preferred amount amount
    dexfenfluramine Hcl 5-30 7.5-20 10-15
    ethanol 5-60 7.5-50 10-20
    propylene glycol 5-30 7.5-20 10-15
    polyethylene glycol 0-60  30-45 35-40
    water 5-30 7.5-20 10-15
    flavors 0.1-5    1-4 2-3
  • EXAMPLE 3 Sulfonylureas
  • A. Glyburide lingual spray
    most preferred
    Amounts preferred amount amount
    Glyburide 0.25-25   0.5-20 0.75-15  
    ethanol 5-60 7.5-50 10-20
    propylene glycol 5-30 7.5-20 10-15
    polyethylene glycol 0-60  30-45 35-40
    water 2.5-30     5-20  6-15
    flavors 0.1-5    1-4 2-3
  • B. Glyburide non-polar bite capsule
    most preferred
    Amounts preferred amount amount
    Glyburide 0.01-10   0.025-7.5  0.1-4  
    olive oil 30-60 35-55 30-50
    polyoxyethylated 30-60 35-55 30-50
    oleic glycerdes
    flavors 0.1-5   1-4 2-3
  • EXAMPLE 4 Antibiotics Anti-Fungals and Anti-Virals
  • A. zidovudine [formerly called azidothymidine
    (AZT) (Retrovir) non-polar lingual spray
    most preferred
    Amounts preferred amount amount
    zidovudine 10-50 15-40 25-35
    Soya oil 20-85 25-70 30-40
    Butane 15-80 30-75 60-70
    flavors 0.1-5   1-4 2-3
  • B. Erythromycin bite capsule bite capsule
    most preferred
    Amounts preferred amount amount
    Erythromycin 25-65  30-50 35-45
    polyoxyethylene glycol 5-70 30-60 45-55
    glycerin 5-20 7.5-15    10-12.5
    flavors 1-10 2-8 3-6
  • C. Ciprofloxacin hydrochloride bite capsule
    most preferred
    Amounts preferred amount amount
    Ciprofloxacin 25-65 35-55 40-50
    hydrochloride
    glycerin  5-20 7.5-15    10-12.5
    polyethylene glycol 20-75 30-65 40-60
    flavors  1-10 2-8 3-6
  • D. zidovudine [formerly called azidothymidine
    (AZT) (Retrovir) lingual spray
    most preferred
    Amounts preferred amount amount
    zidovudine 10-50 15-40 25-35
    water 30-80 40-75 45-70
    ethanol  5-20 7.5-15   9.5-12.5
    polyethylene glycol  5-20 7.5-15   9.5-12.5
    flavors 0.1-5   1-4 2-3
  • EXAMPLE 5 Anti-Emetics
  • A. Ondansetron hydrochloride lingual spray
    most preferred
    Amounts preferred amount amount
    ondansetron 1-25   2-20 2.5-15
    hydrochloride
    citric acid 1-10  2-8 2.5-5 
    monohydrate
    sodium citrate 0.5-5    1-4 1.25-2.5 
    dihydrate
    water 1-90   5-85  10-75
    ethanol 5-30 7.5-20 9.5-15
    propylene glycol 5-30 7.5-20 9.5-15
    polyethylene glycol 5-30 7.5-20 9.5-15
    flavors 1-10  3-8  5-7.5
  • B. Dimenhydrinate bite capsule
    most preferred
    Amounts preferred amount amount
    Dimenhydrinate 0.5-30    2-25  3-15
    glycerin 5-20 7.5-15    10-12.5
    polyethylene glycol 45-95  50-90 55-85
    flavors 1-10 2-8 3-6
  • C. Dimenhydrinate polar lingual spray
    most preferred
    Amounts preferred amount amount
    Dimenhydrinate 3-50 4-40 5-35
    water 5-90 10-80  15-75 
    ethanol 1-80 3-50 5-10
    polyethylene 1-80 3-50 5-15
    glycol
    Sorbitol 0.1-5   0.2-4   0.4-1.0 
    aspartame 0.01-0.5  0.02-0.4  0.04-0.1 
    flavors 0.1-5   1-4  2-3 
  • EXAMPLE 6 Histamine H-2 Receptor Antagonists
  • A. Cimetidine hydrochloride bite capsule
    most preferred
    Amounts preferred amount amount
    Cimetidine Hcl 10-60 15-55 25-50
    glycerin  5-20 7.5-15    10-12.5
    polyethylene glycol 20-90 25-85 30-75
    flavors  1-10 2-8 3-6
  • B. Famotidine lingual spray
    most preferred
    Amounts preferred amount amount
    Famotidine   1-35 5-30 7-20
    water 2.5-25 3-20 5-10
    L-aspartic acid 0.1-20 1-15 5-10
    polyethylene glycol  20-97 30-95  50-85 
    flavors 0.1-10  1-7.5 2-5 
  • C. Famotidine non-polar lingual spray
    most preferred
    Amounts preferred amount amount
    Famotidine  1-35  5-30  7-20
    Soya oil 10-50 15-40 15-20
    Butane 15-80 30-75 45-70
    polyoxyethylated 10-50 15-40 15-20
    oleic glycerides
    flavors 0.1-5   1-4 2-3
  • EXAMPLE 7 Barbiturates
  • A. Phenytoin sodium lingual spray
    most preferred
    Amounts preferred amount amount
    Phenytoin sodium 10-60   15-55  20-40
    water 2.5-25     3-20   5-10
    ethanol 5-30 7.5-20 9.5-15
    propylene glycol 5-30 7.5-20 9.5-15
    polyethylene glycol 5-30 7.5-20 9.5-15
    flavors 1-10  3-8  5-7.5
  • B. Phenytoin non-polar lingual spray
    most preferred
    Amounts preferred amount amount
    Phenytoin  5-45 10-40 15-35
    migylol 10-50 15-40 15-20
    Butane 15-80 30-75 60-70
    polyoxyethylated 10-50 15-40 15-20
    oleic glycerides
    flavors 0.1-10  1-8   5-7.5
  • EXAMPLE 8 Prostaglandins
  • A. Carboprost thromethamine lingual spray
    most preferred
    Amounts preferred amount amount
    Carboprost 0.05-5    0.1-3   0.25-2.5 
    thromethamine
    water 50-95  60-80 65-75
    ethanol 5-20 7.5-15   9.5-12.5
    polyethylene glycol 5-20 7.5-15   9.5-12.5
    sodium chloride 1-20  3-15 4-8
    flavors 0.1-5   1-4 2-3
    pH is adjusted with sodium hydroxide and/or hydrochloric acid
  • B. Carboprost non-polar lingual spray
    most preferred
    Amounts preferred amount amount
    Carboprost 0.05-5   0.1-3   0.25-2.5 
    migylol 25-50 30-45 35-40
    Butane  5-60 10-50 20-35
    polyoxyethylated 25-50 30-45 35-40
    oleic glycerides
    flavors 0.1-10  1-8   5-7.5
  • EXAMPLE 9
  • A. Carnitine as bite capsule (contents are a paste)
    most preferred
    Amounts preferred amount amount
    Carnitine fumarate 6-80 30-70 45-65
    soya oil 7.5-50   10-40 12.5-35  
    soya lecithin 0.001-1.0   0.005-0.5  .01-0.1
    Soya fats 7.5-50   10-40 12.5-35  
    flavors 1-10 2-8 3-6
  • B. Valerian as lingual spray
    most preferred
    Amounts preferred amount amount
    Valerian extract 0.1-10   0.2-7  0.25-5  
    water 50-95   60-80 65-75
    ethanol 5-20 7.5-15  9.5-12.5
    polyethylene glycol 5-20 7.5-15  9.5-12.5
    flavors 1-10  2-8 3-6
  • B. Echinacea as bite capsule
    most preferred
    Amounts preferred amount amount
    Echinacea extract  30-85 40-75 45-55
    soya oil 7.5-50 10-40 12.5-35  
    soya lecithin 0.001-1.0   0.005-0.5  .01-0.1
    Soya fats 7.5-50 10-40 12.5-35  
    flavors   1-10 2-8 3-6
  • B. Mixtures of ingredients
    most preferred
    Amounts preferred amount amount
    Magnesium oxide 15-40  20-35 25-30
    Chromium picolinate 0.01-1.0  0.02-0.5 .025-0.75
    folic acid .025-3.0  0.05-2.0 0.25-0.5 
    vitamin B-12 0.01-1.0  0.02-0.5 .025-0.75
    vitamin E 15-40  20-35 25-30
    Soya oil 10-40 12.5-35  15-20
    soya lecithin 0.1-5   0.2-4  0.5-1.5
    soya fat 10-40  15-35 17.5-20  
  • EXAMPLE 10 Sleep Inducers (Also CNS Active Amine)
  • A. Diphenhydramine hydrochloride lingual spray
    most preferred
    Amounts preferred amount amount
    Diphenhydramine 3-50 4-40  5-35
    Hcl
    water 5-90 10-80  50-75
    ethanol 1-80 3-50  5-10
    polyethylene 1-80 3-50  5-15
    glycol
    Sorbitol 0.1-5   0.2-4   0.4-1.0
    aspartame 0.01-0.5  0.02-0.4  0.04-0.1 
    flavors 0.1-5   1-4  2-3
  • EXAMPLE 11 Anti-Asthmatics-Bronchodilators
  • A. Isoproterenol Hydrochloride as polar lingual spray
    most preferred
    Amounts preferred amount amount
    Isoproterenol 0.1-10   0.2-7.5 0.5-6  
    Hydrochloride
    water 5-90 10-80 50-75
    ethanol 1-80  3-50  5-10
    polyethylene 1-80  3-50  5-15
    glycol
    Sorbitol 0.1-5   0.2-4   0.4-1.0
    aspartame 0.01-0.5  0.02-0.4  0.04-0.1 
    flavors 0.1-5   1-4 2-3
  • B. Terbutaline sulfate as polar lingual spray
    most preferred
    Amounts preferred amount amount
    Terbutaline 0.1-10   0.2-7.5 0.5-6  
    sulfate
    water 5-90 10-80 50-75
    ethanol 1-10 2-8 2.5-5  
    Sorbitol 0.1-5   0.2-4   0.4-1.0
    aspartame 0.01-0.5  0.02-0.4  0.04-0.1 
    flavors 0.1-5   1-4 2-3
  • C. Terbutaline as non-polar lingual spray
    most preferred
    Amounts preferred amount amount
    Terbutaline 0.1-10  0.2-7.5 0.5-6  
    migylol 25-50 30-45 35-40
    isobutane  5-60 10-50 20-35
    polyoxyethylated 25-50 30-45 35-40
    oleic glycerides
    flavors 0.1-10  1-8   5-7.5
  • D. Theophylline polar bite capsule
    most preferred
    Amounts preferred amount amount
    Theophylline  5-50 10-40 15-30
    polyethylene 20-60 25-50 30-40
    glycol
    glycerin 25-50 35-45 30-40
    propylene glycol 25-50 35-45 30-40
    flavors 0.1-5   1-4 2-3
  • E. Albuterol sulfate as polar lingual spray
    most preferred
    Amounts preferred amount amount
    Albuterol sulfate 0.1-10   0.2-7.5 0.5-6  
    water 5-90 10-80 50-75
    ethanol 1-10 2-8 2.5-5  
    Sorbitol 0.1-5   0.2-4   0.4-1.0
    aspartame 0.01-0.5  0.02-0.4  0.04-0.1 
    flavors 0.1-5   1-4 2-3
  • EXAMPLE 12 Polar Solvent Formulations Using a Propellant
  • A. Sulfonylurea
    Most-Preferred
    Amount Preferred Amount Amount
    Glyburide 0.1-25%  0.5-15%  0.6-10% 
    Ethanol 40-99% 60-97% 70-97%
    Water 0.01-5%   0.1-4%   0.2-2%  
    Flavors 0.05-10%   0.1-5%   0.1-2.5%
    Propellant  2-10% 3-5% 3-4%
  • B. Prostaglandin E1 (vasodilator)
    Most-Preferred
    Amount Preferred Amount Amount
    Prostaglandin E1 0.01-10%   0.1-5% 0.2-3%  
    Ethanol 10-90%    20-75% 25-50%
    Propylene glycol 1-90%   5-80% 10-75%
    Water 0.01-5%    0.1-4% 0.2-2%  
    Flavors 0.05-10%   0.1-5% 0.1-2.5%
    Propellant 2-10%   3-5% 3-4%
  • C. Promethazine (antiemetic, sleep
    inducer, and CNS active amine)
    Most-Preferred
    Amount Preferred Amount Amount
    Promethazine 1-25%  3-15%  5-12%
    Ethanol 10-90%  20-75% 25-50%
    Propylene glycol 1-90%  5-80% 10-75%
    Water 0.01-5%    0.1-4%   0.2-2%  
    Flavors 0.05-10%   0.1-5%   0.1-2.5%
    Propellant 2-10% 3-5% 3-4%
  • D. Meclizine
    Most-Preferred
    Amount Preferred Amount Amount
    Meclizine 1-25% 3-15%  5-12%
    Ethanol 1-15% 2-10% 3-6
    Propylene glycol 20-98%  5-90% 10-85%
    Water 0.01-5%    0.1-4%   0.2-2%  
    Flavors 0.05-10%   0.1-5%   0.1-2.5%
    Propellant 2-10% 3-5%  3-4%

Claims (10)

1-29. (canceled)
30. A method for administering an effective amount of a pharmacologically active compound to a mammal to provide transmucosal absorption of a therapeutically effective amount of the active compound through the oral mucosa of the mammal to the systemic circulatory system of the mammal, comprising:
spraying the oral mucosa of the mammal with a propellant free buccal spray composition, containing a pharmacologically active compound dissolved in a pharmacologically acceptable solvent, comprising in weight percent of the composition:
a polar solvent in an amount ranging from 30-99.69%; and
an active compound in an amount ranging from 0.005-55% by weight of the total composition; wherein the active compound is selected from the group consisting of a central nervous system active amine, a sulfonyl urea, an antibiotic, an antiviral, a sleep inducer, an antiasthmatic, an antiemetic, a histamine H-2 receptor antagonist, a barbiturate, a prostaglandin or a bronchial dilator.
31. The method of claim 30, wherein the amount of the spray is predetermined.
32. The method of claim 30, further comprising a flavoring agent in an amount ranging from 0.1 to 10 percent by weight of the composition.
33. The method of claim 32, wherein the polar solvent is present in an amount ranging from 60.9-97.06 percent by weight of the composition, the active compound is present in an amount ranging from 0.01 to 40 percent by weight of the composition, and the flavoring agent is present in an amount ranging from 0.75 to 7.5 percent by weight of the composition.
34. The method of claim 30, wherein the polar solvent comprises a low molecular weight polyethylene glycol (PEG) having a molecular weight ranging from 400 to 1,000, a C2 to C8 mono- and polyalcohol, or an alcohol of C7 to C18 hydrocarbon of linear or branched configuration.
35. The method of claim 30, wherein the solvent comprises aqueous polyethylene alcohol.
36. The method of claim 30, wherein the solvent comprises aqueous ethanol.
37. The method of claim 30, wherein the active compound is selected from the group consisting of cyclosporine, clozapine, zidevudine, ondansetron, carboprost, thromethamine or a pharmaceutically acceptable salt thereof.
38. A method for administering an effective amount of a pharmacologically active compound to a mammal to provide transmucosal absorption of a therapeutically effective amount of the active compound through the oral mucosa of the mammal to the systemic circulatory system of the mammal, comprising:
spraying the oral mucosa of the mammal with a propellant free buccal spray composition, containing a pharmacologically active compound dissolved in a pharmacologically acceptable solvent, comprising in weight percent of the composition:
propylene glycol in an amount of about 60%; and
ondansetron hydrochloride in an amount ranging from 2.5 to 15% by weight of the total composition; wherein a therapeutically effective amount of the active compound is absorbed through the oral mucosa to the systemic circulatory system of the mammal.
US12/350,898 1997-10-01 2009-01-08 Buccal, polar and non-polar spray or capsule Abandoned US20090118170A1 (en)

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PCT/US1997/017899 WO1999016417A1 (en) 1997-10-01 1997-10-01 Buccal, polar and non-polar spray or capsule
US53711800A true 2000-03-29 2000-03-29
US10/100,156 US6676931B2 (en) 1997-10-01 2002-03-18 Buccal, polar and non-polar spray or capsule
US10/663,817 US20040062716A1 (en) 1997-10-01 2003-09-17 Buccal, polar and non-polar spray of capsule
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US10/663,817 Abandoned US20040062716A1 (en) 1997-10-01 2003-09-17 Buccal, polar and non-polar spray of capsule
US11/211,549 Abandoned US20050281753A1 (en) 1997-10-01 2005-08-26 Buccal, polar and non-polar spray or capsule
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US10/663,817 Abandoned US20040062716A1 (en) 1997-10-01 2003-09-17 Buccal, polar and non-polar spray of capsule
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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080170995A1 (en) * 1997-10-01 2008-07-17 Novadel Pharma Inc. Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs
US20090124554A1 (en) * 1997-10-01 2009-05-14 Dugger Iii Harry A Buccal, polar and non-polar spray or capsule containing drugs for treating pain
US20090131514A1 (en) * 1997-10-01 2009-05-21 Dugger Iii Harry A Buccal, polar and non-polar sprays containing propofol
US20090162298A1 (en) * 1997-10-01 2009-06-25 Dugger Iii Harry A Buccal, polar and non-polar spray containing sumatriptan
US20090162297A1 (en) * 1997-10-01 2009-06-25 Dugger Iii Harry A Buccal, polar and non-polar spray containing ondansetron
US20090162300A1 (en) * 1997-10-01 2009-06-25 Dugger Iii Harry A Buccal, polar and non-polar spray containing alprazolam
US20090186035A1 (en) * 1997-10-01 2009-07-23 Dugger Iii Harry A Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer
US20090186099A1 (en) * 1997-10-01 2009-07-23 Dugger Iii Harry A Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
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CA2306024C (en) 2011-04-26

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