US20090099579A1 - Self-adherent implants and methods of preparation - Google Patents

Self-adherent implants and methods of preparation Download PDF

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Publication number
US20090099579A1
US20090099579A1 US12/182,189 US18218908A US2009099579A1 US 20090099579 A1 US20090099579 A1 US 20090099579A1 US 18218908 A US18218908 A US 18218908A US 2009099579 A1 US2009099579 A1 US 2009099579A1
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implant
package
adhesive
combinations
group consisting
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Abandoned
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US12/182,189
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Brian Nentwick
Ahmad Robert Hadba
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Covidien LP
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Covidien LP
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Priority to US12/182,189 priority patent/US20090099579A1/en
Assigned to TYCO HEALTHCARE GROUP LP reassignment TYCO HEALTHCARE GROUP LP ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HADBA, AHMAD ROBERT, NENTWICK, BRIAN
Publication of US20090099579A1 publication Critical patent/US20090099579A1/en
Application status is Abandoned legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0095Packages or dispensers for prostheses or other implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063Implantable repair or support meshes, e.g. hernia meshes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077Special surfaces of prostheses, e.g. for improving ingrowth
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/245Internal membrane, floating cover or the like isolating the contents from the ambient atmosphere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • A61B17/085Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound with adhesive layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063Implantable repair or support meshes, e.g. hernia meshes
    • A61F2002/0072Delivery tools therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30448Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives

Abstract

Implants are described herein which contain an activated adhesive on at least a portion of the surface of the implant. A release sheet may be positioned over at least a portion of the adhesive. Packages which contain the implants and methods of preparing the implants are also described.

Description

    CROSS-REFERENCE TO RELATED APPLICATION
  • The present application claims the benefit of and priority to U.S. Provisional Application Ser. No. 60/999,079, filed on Oct. 16, 2007, the entire disclosure of which is incorporated herein by reference.
  • BACKGROUND
  • 1. Technical Field
  • The present disclosure relates to self-adherent medical implants and packaging for such implants. Methods of preparing self-adherent implants are also disclosed.
  • 2. Background of Related Art
  • Currently methods for securing medical implants, e.g., surgical meshes, to tissue include the use of a variety of fasteners (such as tacks or staples) alone or in combination with adhesives.
  • To work properly fasteners may need to be driven into specific areas of the implant as well as specific areas of the target tissue. As a result, the application of fasteners typically requires the use of graspers or other equipment to manipulate the implants and ensure that the fastener is properly positioned relative to both the implant and the target tissue. Such manipulations, while necessary with conventional fasteners, may undesirably increase the duration of the surgical procedure. In addition, the fasteners support the implants only at the point of penetration and do not distribute the load across the entire surface of the implant.
  • Known methods of using adhesives to secure medical implants to target tissue normally require the implants to be contacted with the adhesive immediately prior to implantation, during the surgery. As a result, the surgeon normally handles implants coated with adhesive materials. These adhesive materials may interact with any surface with which the implant comes into contact, e.g., medical instruments, a surgeon's hands or gloves, tissue other than the intended target tissue, etc.
  • It would be advantageous to provide implants that do not require the use of a fastening device, and that reduce the likelihood that the adhesive-bearing implant will prematurely adhere to unintended surfaces the implant may encounter prior to implantation.
  • SUMMARY
  • Accordingly, the implants described herein contain an adhesive on at least a portion of the surface of the implant and a release sheet overlying at least a portion of the adhesive.
  • Packages for containing implants having an activated adhesive positioned on at least a portion of a surface of the implant are also described. The package includes an internal surface overlying at least a portion of the activated adhesive when the package is closed, wherein at least a portion of the internal surface is a release sheet.
  • In embodiments, the package includes a first cavity containing an adhesive, a second cavity positioned adjacent the first cavity and configured to contain an implant and a rupturable barrier positioned between the first and second cavity. Rupture of the rupturable barrier allows the adhesive to communicate with at least a portion of the second cavity or implant. Dispensers for activating such packaged implants are also contemplated by this disclosure. The dispensers include a compartment containing the above-described packaged implant. The compartment includes a dispensing opening for allowing the passage of the packaged implant therethrough and a structure for rupturing the rupturable barrier of the packaged implant Methods for preparing a self-adherent implant are also described. The methods include the steps of applying an activated adhesive on at least a portion of the implant and overlying at least a portion of the activated adhesive with a release sheet.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 shows a side view of a packaged implant in accordance with an illustrative embodiment described herein.
  • FIG. 2 shows a side view of a packaged implant in accordance with another illustrative embodiment described herein.
  • FIG. 3A shows a side view of a packaged implant in accordance with a two-compartment illustrative embodiment described herein.
  • FIG. 3B shows a top view of the packaged implant of FIG. 3A.
  • FIG. 4 shows a cross-sectional view of an illustrative embodiment of a dispenser for the packaged implant of FIG. 3A.
  • FIG. 5 shows an illustrative embodiment of an apparatus suitable for performing a method of manufacturing an implant in accordance with the present disclosure.
  • FIGS. 6A-6C show an embodiment of a dispenser for the implants described herein.
  • DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
  • Medical implants that are self-adherent, packaging used to contain the implants, dispensers for activating the packaged implants and methods of preparing the self-adherent implants are all described herein. The implants contain an adhesive on at least a portion of the surface of the implant and a release sheet positioned over at least a portion of the adhesive.
  • As used herein, the term “implant” is used in the broadest sense and includes any biocompatible material that can be inserted into a body (human or any other animal) and which may remain in that body for at least some time. Some specific non-limiting examples of suitable implants include surgical meshes, patches, suture anchors, slings, grafts, bone plates, drug delivery devices, wound dressings, woven devices, non-woven devices, braided devices, adhesion barriers, tissue scaffolds, felts, pads, foams, films, fleeces, pledgets, buttresses, and other supportive medical devices. In some embodiments, the self-adherent implant is used to support tissue in pelvic floor prolapse, any type of hernia repair, cosmetic surgeries, arteriole bypass surgeries and wound closures. In embodiments, the implant is a surgical mesh.
  • The implants described herein can be formed from any sterilizable material that has suitable physical properties for the intended use of the implant. For example, the implants can be made from bioabsorbable, non-bioabsorbable, natural or synthetic polymeric materials, metallic materials and combinations thereof. Some specific non-limiting examples of suitable absorbable materials which may be utilized to form the implants include trimethylene carbonate, caprolactone, dioxanone, glycolic acid, lactic acid, glycolide, lactide, alkyl derivatives of trimethylene carbonate, delta.-valerolactone, β-butyrolactone, γ-butyrolactone, ε-decalactone, hydroxybutyrate, hydroxyvalerate, 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclotetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one and polymer blends, homopolymers, copolymers and combinations thereof. Some specific non-limiting examples of suitable non-absorbable materials which may be utilized to form the medical implant include polyethylene, polypropylene, polyester, polyethylene terephthalate, polytetrafluoroethylene, polyaryletherketone, acrylic, polyamides, aramids, fluropolymers, polybutester, silicone and flurocarbons cotton, linen, silk, polyamides, polyhexamethylene adipamide, polyhexamethylene sebacamide, polycapramide, polydodecanamide, and polyhexamethylene isophthalamide, polymer blends, homopolymers, copolymers and combinations thereof. In addition, the polymeric materials can include a naturally occurring biological molecule, or a variant thereof, such as collagen, gelatin, cellulose, starches, polysaccharides, alginate, chitosan, hyaluronic acid and combinations thereof. Also, some examples of metallic materials include, stainless steel, metal alloys, and shape-memory materials, e.g., nitinol.
  • The implants may contain any adhesive capable of adhering or attaching the implant to the target tissue. The adhesive may be biodegradable, non-biodegradable, bioabsorbable, non-bioabsorbable, natural, synthetic, and any combination thereof. The adhesives may include, for example, α-cyanoacrylates, isocyanates, polyurethanes, polyamines, polyamides, polymethacrylates, polyacrylates, and other synthetic monomers and polymers and combinations thereof. Some non-limiting examples of natural materials that may be positioned on at least a portion of the implant include fibrin, collagen, albumin, thrombin, gelatin, proteins and combinations thereof.
  • The adhesives may be activated at the time of application to the implant, or may require activation subsequent to application to the implant. By the term activated, it is meant that the adhesive is tacky without any further treatment and will adhere to surfaces with which it comes into contact. In embodiments, the adhesive is a material which is prepared to react with the target tissue to attach the implant without requiring activation or the addition of an initiator, diluent or cross-linker. That is not to say that initiators, diluents and cross-linkers may not be used, but rather that in the interest of efficiency, packaged implants which contain an activated adhesive are advantageous.
  • The adhesive can be positioned on any portion of the implant and in any manner suitable to coating an implant. In some embodiments, the adhesive is positioned on an outer surface of the implant. In some embodiments, the adhesive is allowed to penetrate into the implant. Some suitable methods for applying the adhesive to the medical device include, but are not limited to, dipping, brushing, spraying, painting, dotting, layering, patterning and wiping. In some embodiments, the adhesive may be applied by dip coating the medical implant directly into an adhesive solution. In other embodiments, the adhesive is in the form of a solid, e.g., powder, particulate matter or coating layer which may be sprayed, wiped or brushed onto the surface of the implants.
  • In embodiments in which the implant may be used to support tissue, certain portions of the implant may require more adhesive to fully support a given tissue. It is envisioned that the adhesive may be placed onto the medical implant in any pattern, and in varying concentrations, to further enhance the implant's ability to adhere to and support the target tissue.
  • A release sheet is positioned over at least a portion of the adhesive. The release sheet is designed to prevent contact or interaction with the adhesive prior to implantation thereby allowing medical personnel to handle the implant without fear of prematurely attaching the implant to an unintended surface. The release sheet also allows the implant to be folded, rolled or twisted in any manner while preventing the adhesive from contacting any portion of the implant thereby preventing the implant from sticking to itself. The release sheet may be made from any bioabsorbable or non-bioabsorbable material which is non-reactive to the adhesive. Some examples include, but are not limited to, polylactones, polytetrafluoroethylene, polyolefins, metalized polymer films, metallic foils and combinations thereof In particularly useful embodiments, the release sheet may be made from polytetrafluoroethylene.
  • In some embodiments, the release sheet is made of a material which dissolves when placed in contact with water, saline or other natural bodily fluids including blood, mucous, sweat, saliva and the like. Some examples of dissolvable materials include, but are not limited to, polyvinyl pyrrolidones, polyethylene glycols, polyvinyl alcohols, polyacrylic acids, carboxymethylcellulose, alginates, hyaluronic acids, dextrans, polysaccharides, gelatins, and combinations thereof The dissolvable release sheet is designed to prevent contact or interaction with the adhesive prior to implantation and expose the adhesive after interaction with a particular bodily fluid in which the release sheet is dissolvable.
  • Turning now to FIG. 1, implant 10 is shown containing an adhesive 12 positioned on at least a portion of the surface 11 of implant 10 and a release sheet 15 overlying at least a portion of adhesive 12 to inhibit contact of adhesive 12. Package 20, which includes top layer 22 and bottom layer 24, contains implant 10 including adhesive 12 and release sheet 15. It is envisioned that top layer 22 of package 20 may be opened or peeled away from bottom layer 24 to access implant 10 while adhesive 12 remains covered by release sheet 15. Implant 10 may then be positioned at the site of implantation by medical personnel while release sheet 15 remains in contact with adhesive 12. Medical personnel may then remove release sheet 15 from implant 10 to expose adhesive 12 and position the adhesive 12 directly into contact with the target tissue for a period of time sufficient for adhesive 12 to form a bond with the target tissue.
  • In other embodiments, as shown in FIG. 2, top layer 22 of package 20 includes an internal surface 25, a portion of which is release sheet 15. As described herein top layer 22 of package 20 may be opened or peeled away from bottom layer 24 to access implant 10 including adhesive 12. Top layer 22 includes a portion of which acts as a release sheet. The top layer may itself be made from a material that acts as a release sheet, or as shown in FIG. 2 top layer 22 may have release sheet 15 adhered thereto. Upon removal of bottom layer 24, top layer 22 will remain with implant 10 to protect against inadvertent contact with adhesive 12. Once implant 10 has been properly positioned, medical personnel may then remove top layer 22 (including release sheet 15) from implant 10 to expose adhesive 12 and position adhesive 12 directly into contact with the target tissue for a period of time sufficient for adhesive 12 to form a bond with the target tissue.
  • The package may be any conventional enclosure for storing implants. Some examples of useful packages include, but are not limited too, pouches, paper retainers, plastic retainers, bags, trays, envelopes, Tyvek® bags, foil-packs, and the like. It is envisioned that the packages may be sealable, non-sealable, breathable, non-breathable, peelable, resealable, and combinations thereof.
  • The package may be manufactured from any material known to those skilled in the art which is suitable for receiving or storing an implant. Some examples of suitable materials include, but are not limited to, polycarbonate, high-density polyethylene, polyethylene, polypropylene, thermoplastic elastomers, thermosets, thermoplastic resins, metalized polymers, poly(ethylene terephthalate), polytetrafluoroethylene, ε-caprolactone, glycolide, 1-lactide, d,1-lactide, d-lactide, meso-lactide, trimethylene carbonate, 4,4-dimethyl-1,3-dioxan-2-one, p-dioxanone, dioxepanone, δ-valerolactone, β-butyrolactone, ε-decalactone, 2,5-diketomorpholine, pivalolactone, α,α-diethylpropiolactone, 6,8-dioxabicyclooctan-7-one, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-dimethyl-1,4-dioxane-2,5-dione, polyolefins, polysiloxanes, polyalkylene glycols, polyacrylates, aminoalkyl acrylates, polyvinylalcohols, polyvinylpyrrolidones, polyoxyethylenes, polyacrylamides, poly(2-hydroxy-ethylmethacrylate), polymethacrylamide, dextran, alginic acid, sodium alginate, polysaccharides, gelatin and copolymers, homopolymers, and block copolymers thereof.
  • The package is dimensioned and configured to receive an implant. In some embodiments, the package may include a single cavity for receiving the implant. In other embodiments, the package may include more than one cavity for receiving the implant and the adhesive separately. For example, as shown in FIGS. 3A and 3B, package 20 may include a first cavity 26 containing an adhesive 12 and a second cavity 28 positioned adjacent first cavity 26 and configured to contain implant 10. Package 20 further includes rupturable barrier 35 which is positioned between first cavity 26 and second cavity 28. Upon rupture of rupturable barrier 35, adhesive 12 can communicate with at least a portion of second cavity 28.
  • It is envisioned that prior to implantation, the barrier may be pierced, broken, removed or opened to allow the adhesive contained in the first cavity to flow onto at least a portion of the implant contained in the second cavity thereby positioning the adhesive on at least a portion of the implant. In embodiments, the barrier may be formed by a portion of the top and bottom layers of packaging. In other embodiments, the barrier may be a separate member positioned between the first and second cavity, which when exposed to a certain force, e.g., pressure, temperature, etc., the barrier will break or move to allow for the passage of the adhesive from the first cavity to the second cavity. As further shown in FIG. 3B, top layer 22 and bottom layer 24 of package 20 may be heat-sealed around the perimeter of package 20 and may be peeled apart to open package 20 to remove implant 10 having at least a portion of adhesive 12 positioned thereon.
  • Turning now to FIG. 4, a dispenser 50 is shown including compartment 60 for containing package 20 of the type shown in FIG. 3A having a first cavity 26 containing a medical adhesive 12, a second cavity 28 configured to contain a medical implant 10 and a rupturable barrier 35 therebetween. Compartment 60 further includes a dispensing opening 70 and a structure 80 for rupturing the rupturable barrier 35. Because compartment 26 is thicker than opening 70, pulling package 20 out of compartment 60 through opening 70 will result in rupture of rupturable barrier 35. Structure 80 in this embodiment is a contoured ridge that reduces the size of opening 70 and provides a smooth surface against which package 20 is compressed to rupture rupturable barrier 35 without tearing open compartment 36. In this manner, adhesive 12 can move into compartment 28 without leaving the interior of package 20. Thus, dispensing opening 70 is designed and configured to allow for the passage of the packaged implant out of compartment 60, but only after the rupturable barrier has been ruptured and at least some of adhesive 12 moves into cavity 28 and into contact with implant 10.
  • As package 20 is withdrawn from dispenser 50, structure 80 applies pressure, pierces or forces open rupturable barrier 35 thereby allowing adhesive 12 to flow from first cavity 26 to second cavity 28. Dispenser 50 may further include structure 90 for distributing the adhesive over at least a portion of implant 10. Examples of structures capable of distributing the adhesive to at least a portion of the implant include, but are not limited to, rollers, brushes, wipers and the like. In particularly useful embodiments, the dispenser will include at least one roller to assist in spreading the adhesive onto the implant as the package is withdrawn from the dispenser.
  • It is envisioned that following the removal of the packaged implant from the dispenser, the package may be opened to expose the coated implant. In some embodiments, the coated implant may remain in a portion of the package, typically the bottom portion of the package, so that the coated implant may be manipulated without prematurely attaching to an unintended surface.
  • In some embodiments, as shown in FIGS. 6A-6C, dispenser 450 includes dispensing opening 470 and compartment 460 for containing implant 410, rupturable barrier 435 and adhesive 412. Dispenser 450 is shown pivotably connected to surgical introducer 500 which is used to position implant 410 at the site of implantation. It is envisioned that introducer 500 may be used to guide dispenser 450 through any surgical opening or trocar to the site of implantation.
  • As shown in FIG. 6B, dispenser 450 may pivot or articulate to one side of introducer 500 thereby breaking open rupturable barrier 435 and releasing adhesive 412 on implant 410. As dispenser 450 is articulated in the opposite direction as shown in FIG. 6C, implant 410 may exit or be withdrawn from dispenser 450 via dispensing opening 470 and positioned at the site of implantation. The adhesive will react with the tissue or fluids at the site of implantation securing the implant to the tissue. Once implant 410 is outside dispenser 450, dispenser 450 may return to the straight position as shown FIG. 6A for removal from inside the body.
  • It is envisioned that dispenser 450 may include additional structures which may be helpful in rupturing rupturable barrier 435 or useful in applying adhesive 412 to implant 410. Some examples are described herein and include, but are not meant to limited to, rollers, brushes, wipers, and the like.
  • In some embodiments implant 410 may be coated with an adhesive which is designed to react only with the tissue located at the site of implantation and as a result does not react with the implant, the dispenser thereby eliminating the need for a rupturable barrier 435. In some embodiments, implant 410 may include adhesive 412 covered by a release sheet which upon implantation may be removed or dissolved to expose the adhesive on the implant.
  • The self-adherent implants described herein may additionally include a bioactive agent. The bioactive agent may be combined with the material used to form the implant and/or the adhesive. In addition, the bioactive agent may be applied to a portion of the implant and/or adhesive. The term “bioactive agent”, as used herein, is used in its broadest sense and includes any substance or mixture of substances that have clinical use. Consequently, bioactive agents may or may not have pharmacological activity per se, e.g., a dye, or fragrance. Alternatively a bioactive agent could be any agent which provides a therapeutic or prophylactic effect, a compound that affects or participates in tissue growth, cell growth, cell differentiation, an anti-adhesive compound, a compound that may be able to invoke a biological action such as an immune response, or could play any other role in one or more biological processes. It is envisioned that the bioactive agent may be applied to the implant in any suitable form of matter, e.g., films, powders, liquids, gels and the like.
  • Examples of classes of bioactive agents which may be utilized in accordance with the present disclosure include anti-adhesives, antimicrobials, analgesics, antipyretics, anesthetics, antiepileptics, antihistamines, anti-inflammatories, cardiovascular drugs, diagnostic agents, sympathomimetics, cholinomimetics, antimuscarinics, antispasmodics, hormones, growth factors, muscle relaxants, adrenergic neuron blockers, antineoplastics, immunogenic agents, immunosuppressants, gastrointestinal drugs, diuretics, steroids, lipids, lipopolysaccharides, polysaccharides, and enzymes. It is also intended that combinations of bioactive agents may be used.
  • Anti-adhesive agents can be used to prevent adhesions from forming between the implants and the surrounding tissues opposite the target tissue. In addition, anti-adhesive agents may be used to prevent adhesions from forming between the implants and the packaging material. Some examples of these agents include, but are not limited to poly(vinyl pyrrolidone), carboxymethyl cellulose, hyaluronic acid, polyethylene oxide, poly vinyl alcohols and combinations thereof.
  • Suitable antimicrobial agents which may be included as a bioactive agent in the present disclosure include triclosan, also known as 2,4,4′-trichloro-2′-hydroxydiphenyl ether, chlorhexidine and its salts, including chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, and chlorhexidine sulfate, silver and its salts, including silver acetate, silver benzoate, silver carbonate, silver citrate, silver iodate, silver iodide, silver lactate, silver laurate, silver nitrate, silver oxide, silver palmitate, silver protein, and silver sulfadiazine, polymyxin, tetracycline, aminoglycosides, such as tobramycin and gentamicin, rifampicin, bacitracin, neomycin, chloramphenicol, miconazole, quinolones such as oxolinic acid, norfloxacin, nalidixic acid, pefloxacin, enoxacin and ciprofloxacin, penicillins such as oxacillin and pipracil, nonoxynol 9, fusidic acid, cephalosporins, and combinations thereof. In addition, antimicrobial proteins and peptides such as bovine lactoferrin and lactoferricin B may be included as a bioactive agent in the present disclosure.
  • Other bioactive agents which may be included as a bioactive agent in accordance with the present disclosure include: local anesthetics; non-steroidal antifertility agents; parasympathomimetic agents; psychotherapeutic agents; tranquilizers; decongestants; sedative hypnotics; steroids; sulfonamides; sympathomimetic agents; vaccines; vitamins; antimalarials; anti-migraine agents; anti-parkinson agents such as L-dopa; anti-spasmodics; anticholinergic agents (e.g. oxybutynin); antitussives; bronchodilators; cardiovascular agents such as coronary vasodilators and nitroglycerin; alkaloids; analgesics; narcotics such as codeine, dihydrocodeinone, meperidine, morphine and the like; non-narcotics such as salicylates, aspirin, acetaminophen, d-propoxyphene and the like; opioid receptor antagonists, such as naltrexone and naloxone; anti-cancer agents; anti-convulsants; anti-emetics; antihistamines; anti-inflammatory agents such as hormonal agents, hydrocortisone, prednisolone, prednisone, non-hormonal agents, allopurinol, indomethacin, phenylbutazone and the like; prostaglandins and cytotoxic drugs; estrogens; antibacterials; antibiotics; anti-fungals; anti-virals; anticoagulants; anticonvulsants; antidepressants; antihistamines; and immunological agents.
  • Other examples of suitable bioactive agents include viruses and cells, peptides, polypeptides and proteins, analogs, muteins, and active fragments thereof, such as immunoglobulins, antibodies, cytokines (e.g. lymphokines, monokines, chemokines), blood clotting factors, hemopoietic factors, interleukins (IL-2, IL-3, IL4, IL-6), interferons (β-IFN, (α-IFN and γ-IFN), erythropoietin, nucleases, tumor necrosis factor, colony stimulating factors (e.g., GCSF, GM-CSF, MCSF), insulin, anti-tumor agents and tumor suppressors, blood proteins, gonadotropins (e.g., FSH, LH, CG, etc.), hormones and hormone analogs (e.g., growth hormone), vaccines (e.g., tumoral, bacterial and viral antigens); somatostatin; antigens; blood coagulation factors; growth factors (e.g., nerve growth factor, insulin-like growth factor); protein inhibitors, protein antagonists, and protein agonists; nucleic acids, such as antisense molecules, DNA and RNA; oligonucleotides; polynucleotides; and ribozymes.
  • Now turning to FIG. 5, a particularly useful method of preparing self-adherent implants as described herein is shown. Implant 150 is shown being moved horizontally around a series of rollers 130A-D. Implant 150, e.g., a polypropylene surgical mesh, is moved through bath 140 which contains an adhesive solution 160 to be applied to at least a portion of implant 150. Although specifically shown as being dipped in bath 140, adhesive solution 160 can be applied to medical implant 150 in any suitable manner for coating the implant. After exiting bath 140, implant 150 proceeds between a set of pinch rollers 180, 190 which may remove excess adhesive solution 160 and continues through a pair of cutting edges 212, 214. The cutting edges 212, 214 may be forced together to separate implant 150 into predetermined lengths and widths. Once the implant 150 is cut into size, a top layer 224 and a bottom layer 222 of packaging material may be used to “sandwich” the cut implant 150. Medical implant 150, sandwiched between top layer 224 and bottom layer 222, proceeds to enter a sealing device 230 wherein top layer 224 and bottom layer 222 are cut and sealed along the outer perimeter around implant 150. Although specifically shown as being cut by cutting edges 212, 214 prior to being packaged and sealed, implant 150 may be cut, packaged and sealed in any order suitable to producing a sterilized medical implant as described herein.
  • Since the self-adherent implant is intended and designed to be inserted into the human body, the implant must be sterilized prior to use. The sterilization of the implant, the package which contains the implant and the dispenser which dispenses the packaged implant may be sterilized at anytime, including before and after packaging of the implant. The sterilization process can be performed using various methods known to one skilled in the art, including, gamma radiation and gaseous sterilization with steam or ethylene oxide.
  • It will be understood that various modifications may be made to the embodiments disclosed herein. For example, it is contemplated that both sides of the implant can be coated with adhesive and that both layers of the package may serve as or include a release sheet. As another example, the structure for rupturing the rupturable barrier may be spring loaded, rather than a simple pair of rollers. As yet another example, the dual compartment package may include in one compartment an implant coated with an inactivated adhesive and an activation solution in the second compartment, rather than an uncoated implant and an adhesive as described above. The activating solution may be water or a composition containing initiators, crosslinkers, diluents and the like. Therefore, the above description should not be construed as limiting, but merely as exemplifications of preferred embodiments. Those skilled in art will envision other modifications within the scope and spirit of the claims appended hereto.

Claims (36)

1. An implant comprising:
an activated adhesive positioned on at least a portion of a surface of said implant and
a release sheet overlying at least a portion of said adhesive to inhibit contact of said adhesive.
2. The implant of claim 1 wherein the implant is selected from the group consisting of surgical meshes, suture anchors, slings, pins, screws, drug delivery devices, adhesion barriers, patches, clips, pledgets, and combinations thereof.
3. The implant of claim 1 wherein the implant is a surgical mesh.
4. The implant of claim 1 wherein the activated adhesive is selected from the group consisting of polyurethanes, isocyanates and combinations thereof.
5. The implant of claim 1 wherein the activated adhesive penetrates into the implant
6. The implant of claim 1 wherein the release sheet comprises a bioabsorbable material.
7. The implant of claim 6 wherein the release sheet is selected from the group consisting of polylactide, polyglycolide, polycaprolactone, polydioxanone and combinations thereof.
8. The implant of claim 1 wherein the release sheet comprises a non-bioabsorbable material.
9. The implant of claim 8 wherein the release sheet comprises a material selected from the group consisting of polytetrafluoroethylene, polyethylene, polypropylene, metalized polymer films, and combinations thereof.
10. The implant of claim 1 wherein the release sheet comprises a dissolvable material.
11. The implant of claim 10 wherein the dissolvable material is selected from the group consisting of polyvinyl pyrrolidone, polyethylene glycol, polyvinyl alcohols, polyacrylic acid, carboxymethylcellulose, alginate, hyaluronic acid, dextran, polysaccharides, gelatin, and combinations thereof.
12. A package containing an implant comprising:
an activated adhesive positioned on at least a portion of a surface of the implant, the package including an internal surface, overlying at least a portion of said activated adhesive when said package is closed, wherein at least a portion of said internal surface is a release sheet.
13. The package of claim 12 wherein the implant is selected from the group consisting of surgical mesh, suture anchors, slings, pins, screws, drug delivery devices, adhesion barriers, patches, clips, pledgets, and combinations thereof.
14. The package of claim 12 wherein the implant is a surgical mesh.
15. The package of claim 12 wherein the activated adhesive is selected from the group consisting of polyurethanes, isocyanates and combinations thereof.
16. The package of claim 12 wherein the activated adhesive penetrates into the implant.
17. The package of claim 12 wherein the release sheet comprises a bioabsorbable material.
18. The package of claim 17 wherein the release sheet is selected from the group consisting of polylactide, polyglycolide, polycaprolactone, polydioxanone and combinations thereof.
19. The package of claim 12 wherein the release sheet comprises a non-bioabsorbable material.
20. The package of claim 19 wherein the release sheet comprises a material selected from the group consisting of polytetrafluoroethylene, polyethylene, polypropylene, metalized polymer films, and combinations thereof.
21. The implant of claim 12 wherein the release sheet comprises a dissolvable material.
22. The implant of claim 21 wherein the dissolvable material is selected from the group consisting of polyvinyl pyrrolidone, polyethylene glycol, polyvinyl alcohols, polyacrylic acid, carboxymethylcellulose, alginate, hyaluronic acid, dextran, polysaccharides, gelatin, and combinations thereof.
23. A package for containing an implant, said package comprising:
a first cavity containing a medical adhesive;
a second cavity positioned adjacent said first cavity and configured to contain an implant and
a rupturable barrier positioned between said first and second cavity wherein, upon rupture of said rupturable barrier, said adhesive can communicate with at least a portion of said second cavity.
24. The package of claim 23 wherein the implant is selected from the group consisting of surgical mesh, suture anchors, slings, pins, screws, drug delivery devices, adhesion barriers, patches, clips, pledgets, and combinations thereof.
25. The package of claim 23 wherein the implant is a surgical mesh.
26. The package of claim 23 wherein the medical adhesive is selected from the group consisting of polyurethanes, isocyanates and combinations thereof.
27. The package of claim 23 wherein the medical adhesive is a polyurethane.
28. The package of claim 23 wherein the rupturable barrier is formed from at least a portion of the packaging materials.
29. A dispenser for activating packaged implants, said packaged implants having a first cavity containing a medical adhesive, a second cavity configured to contain a medical implant and a rupturable barrier therebetween, said packaged implants being activated by the rupture of said rupturable barrier said dispenser comprising:
a compartment for containing said packaged implant, said compartment including a dispensing opening and structure for rupturing said rupturable barrier.
30. The package of claim 29 wherein the implant is selected from the group consisting of surgical mesh, suture anchors, slings, pins, screws, drug delivery devices, adhesion barriers, patches, clips, pledgets, and combinations thereof.
31. The package of claim 29 wherein the implant is a surgical mesh.
32. The package of claim 29 wherein the medical adhesive is selected from the group consisting of polyurethanes, isocyanates and combinations thereof.
33. The package of claim 29 further comprising a structure for applying the medical adhesive to at least apportion of the implant.
34. The package of claim 33 wherein the structure for applying the medical adhesive is selected from the group consisting of wipers, rollers, brushes and combinations thereof.
35. The package of claim 34 wherein the structure for applying the medical adhesive is a roller.
36. A method for preparing a self-adherent implant comprising the steps of: applying an activated adhesive on at least a portion of the implant; and overlying at least a portion of the activated adhesive with a release sheet.
US12/182,189 2007-10-16 2008-07-30 Self-adherent implants and methods of preparation Abandoned US20090099579A1 (en)

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CA002639472A CA2639472A1 (en) 2007-10-16 2008-09-11 Self-adherent implants and methods of preparation
EP11191001.4A EP2436404B1 (en) 2007-10-16 2008-09-30 Self-adherent implants and methods of preparation
ES08253182T ES2380410T3 (en) 2007-10-16 2008-09-30 Self-adhesive medical implants and methods of preparation
EP08253182A EP2050474B1 (en) 2007-10-16 2008-09-30 Self- adherent implants and methods of preparation
JP2008259098A JP2009095667A (en) 2007-10-16 2008-10-03 Self-adherent implants and methods of preparation
US13/549,915 US9241781B2 (en) 2007-10-16 2012-07-16 Self-adherent implants and methods of preparation
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Cited By (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090206125A1 (en) * 2008-02-15 2009-08-20 Ethicon Endo-Surgery, Inc. Packaging for attaching buttress material to a surgical stapling instrument
US20100318121A1 (en) * 2008-10-20 2010-12-16 PolyTouch Medical, Inc. Device and method for attaching an implant to biological tissue
WO2011055368A2 (en) * 2009-11-09 2011-05-12 Ionmed Ltd Plasma head for tissue welding
US20120312860A1 (en) * 2010-09-30 2012-12-13 Xintian Ming Tissue stapler having a thickness compensator incorporating an anti-microbial agent
US20130178947A1 (en) * 2012-01-09 2013-07-11 Zimmer, Inc. Porous metal implants with bone cement
US20130225918A1 (en) * 2011-08-30 2013-08-29 Boston Scientific Scimed, Inc. Materials and methods for securing bodily implants
US8608775B2 (en) 2011-01-24 2013-12-17 Covidien Lp Two part tape adhesive for wound closure
US9084601B2 (en) 2008-02-14 2015-07-21 Ethicon Endo-Surgery, Inc. Detachable motor powered surgical instrument
US20150209129A1 (en) * 2012-09-28 2015-07-30 Sofradim Production Packaging for a Hernia Repair Device
US9096367B2 (en) 2009-05-30 2015-08-04 Jiangsu Synecoun Medical Technology Co., Ltd. Product having bioresorbable carrier materials and packaging
US9101358B2 (en) 2012-06-15 2015-08-11 Ethicon Endo-Surgery, Inc. Articulatable surgical instrument comprising a firing drive
US9101385B2 (en) 2012-06-28 2015-08-11 Ethicon Endo-Surgery, Inc. Electrode connections for rotary driven surgical tools
US9113874B2 (en) 2006-01-31 2015-08-25 Ethicon Endo-Surgery, Inc. Surgical instrument system
US9179911B2 (en) 2006-09-29 2015-11-10 Ethicon Endo-Surgery, Inc. End effector for use with a surgical fastening instrument
US9186143B2 (en) 2007-06-04 2015-11-17 Ethicon Endo-Surgery, Inc. Robotically-controlled shaft based rotary drive systems for surgical instruments
US9198662B2 (en) 2012-03-28 2015-12-01 Ethicon Endo-Surgery, Inc. Tissue thickness compensator having improved visibility
US9204880B2 (en) 2012-03-28 2015-12-08 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising capsules defining a low pressure environment
US9204878B2 (en) 2008-02-14 2015-12-08 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
US9211120B2 (en) 2011-04-29 2015-12-15 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a plurality of medicaments
US9211121B2 (en) 2008-02-14 2015-12-15 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus
US9220500B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising structure to produce a resilient load
US9220501B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensators
US9271799B2 (en) 2011-05-27 2016-03-01 Ethicon Endo-Surgery, Llc Robotic surgical system with removable motor housing
US9272406B2 (en) 2010-09-30 2016-03-01 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a cutting member for releasing a tissue thickness compensator
US9283054B2 (en) 2013-08-23 2016-03-15 Ethicon Endo-Surgery, Llc Interactive displays
US9289206B2 (en) 2007-06-29 2016-03-22 Ethicon Endo-Surgery, Llc Lateral securement members for surgical staple cartridges
US9289256B2 (en) 2012-06-28 2016-03-22 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US9301752B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising a plurality of capsules
US9301759B2 (en) 2006-03-23 2016-04-05 Ethicon Endo-Surgery, Llc Robotically-controlled surgical instrument with selectively articulatable end effector
US9307988B2 (en) 2005-08-31 2016-04-12 Ethicon Endo-Surgery, Llc Staple cartridges for forming staples having differing formed staple heights
US9307989B2 (en) 2012-03-28 2016-04-12 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorportating a hydrophobic agent
US9307986B2 (en) 2013-03-01 2016-04-12 Ethicon Endo-Surgery, Llc Surgical instrument soft stop
US9314246B2 (en) 2010-09-30 2016-04-19 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent
US9320523B2 (en) 2012-03-28 2016-04-26 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising tissue ingrowth features
US9326769B2 (en) 2006-01-31 2016-05-03 Ethicon Endo-Surgery, Llc Surgical instrument
US9326768B2 (en) 2005-08-31 2016-05-03 Ethicon Endo-Surgery, Llc Staple cartridges for forming staples having differing formed staple heights
US9332974B2 (en) 2010-09-30 2016-05-10 Ethicon Endo-Surgery, Llc Layered tissue thickness compensator
US9332987B2 (en) 2013-03-14 2016-05-10 Ethicon Endo-Surgery, Llc Control arrangements for a drive member of a surgical instrument
US9332984B2 (en) 2013-03-27 2016-05-10 Ethicon Endo-Surgery, Llc Fastener cartridge assemblies
US9345481B2 (en) 2013-03-13 2016-05-24 Ethicon Endo-Surgery, Llc Staple cartridge tissue thickness sensor system
US9351726B2 (en) 2013-03-14 2016-05-31 Ethicon Endo-Surgery, Llc Articulation control system for articulatable surgical instruments
US9358005B2 (en) 2010-09-30 2016-06-07 Ethicon Endo-Surgery, Llc End effector layer including holding features
US9364233B2 (en) 2010-09-30 2016-06-14 Ethicon Endo-Surgery, Llc Tissue thickness compensators for circular surgical staplers
US9364230B2 (en) 2012-06-28 2016-06-14 Ethicon Endo-Surgery, Llc Surgical stapling instruments with rotary joint assemblies
US9370358B2 (en) 2006-01-31 2016-06-21 Ethicon Endo-Surgery, Llc Motor-driven surgical cutting and fastening instrument with tactile position feedback
US9370364B2 (en) 2008-10-10 2016-06-21 Ethicon Endo-Surgery, Llc Powered surgical cutting and stapling apparatus with manually retractable firing system
US9386984B2 (en) 2013-02-08 2016-07-12 Ethicon Endo-Surgery, Llc Staple cartridge comprising a releasable cover
US9393015B2 (en) 2009-02-06 2016-07-19 Ethicon Endo-Surgery, Llc Motor driven surgical fastener device with cutting member reversing mechanism
US9402626B2 (en) 2006-03-23 2016-08-02 Ethicon Endo-Surgery, Llc Rotary actuatable surgical fastener and cutter
US9408606B2 (en) 2012-06-28 2016-08-09 Ethicon Endo-Surgery, Llc Robotically powered surgical device with manually-actuatable reversing system
US9486214B2 (en) 2009-02-06 2016-11-08 Ethicon Endo-Surgery, Llc Motor driven surgical fastener device with switching system configured to prevent firing initiation until activated
US9510830B2 (en) 2004-07-28 2016-12-06 Ethicon Endo-Surgery, Llc Staple cartridge
US9522029B2 (en) 2008-02-14 2016-12-20 Ethicon Endo-Surgery, Llc Motorized surgical cutting and fastening instrument having handle based power source
US9572577B2 (en) 2013-03-27 2017-02-21 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a tissue thickness compensator including openings therein
US9574644B2 (en) 2013-05-30 2017-02-21 Ethicon Endo-Surgery, Llc Power module for use with a surgical instrument
US9585657B2 (en) 2008-02-15 2017-03-07 Ethicon Endo-Surgery, Llc Actuator for releasing a layer of material from a surgical end effector
US9592052B2 (en) 2005-08-31 2017-03-14 Ethicon Endo-Surgery, Llc Stapling assembly for forming different formed staple heights
US9592054B2 (en) 2011-09-23 2017-03-14 Ethicon Endo-Surgery, Llc Surgical stapler with stationary staple drivers
US9592053B2 (en) 2010-09-30 2017-03-14 Ethicon Endo-Surgery, Llc Staple cartridge comprising multiple regions
US9597075B2 (en) 2010-07-30 2017-03-21 Ethicon Endo-Surgery, Inc. Tissue acquisition arrangements and methods for surgical stapling devices
US9603991B2 (en) 2004-07-28 2017-03-28 Ethicon Endo-Surgery, Llc Surgical stapling instrument having a medical substance dispenser
US9603598B2 (en) 2007-01-11 2017-03-28 Ethicon Endo-Surgery, Llc Surgical stapling device with a curved end effector
US9615826B2 (en) 2010-09-30 2017-04-11 Ethicon Endo-Surgery, Llc Multiple thickness implantable layers for surgical stapling devices
US9629629B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgey, LLC Control systems for surgical instruments
US9629814B2 (en) 2010-09-30 2017-04-25 Ethicon Endo-Surgery, Llc Tissue thickness compensator configured to redistribute compressive forces
US9649111B2 (en) 2012-06-28 2017-05-16 Ethicon Endo-Surgery, Llc Replaceable clip cartridge for a clip applier
US9649110B2 (en) 2013-04-16 2017-05-16 Ethicon Llc Surgical instrument comprising a closing drive and a firing drive operated from the same rotatable output
US9655614B2 (en) 2008-09-23 2017-05-23 Ethicon Endo-Surgery, Llc Robotically-controlled motorized surgical instrument with an end effector
US9662110B2 (en) 2007-06-22 2017-05-30 Ethicon Endo-Surgery, Llc Surgical stapling instrument with an articulatable end effector
US9690362B2 (en) 2014-03-26 2017-06-27 Ethicon Llc Surgical instrument control circuit having a safety processor
US9687237B2 (en) 2011-09-23 2017-06-27 Ethicon Endo-Surgery, Llc Staple cartridge including collapsible deck arrangement
US9693777B2 (en) 2014-02-24 2017-07-04 Ethicon Llc Implantable layers comprising a pressed region
US9724098B2 (en) 2012-03-28 2017-08-08 Ethicon Endo-Surgery, Llc Staple cartridge comprising an implantable layer
US9724094B2 (en) 2014-09-05 2017-08-08 Ethicon Llc Adjunct with integrated sensors to quantify tissue compression
US9730697B2 (en) 2012-02-13 2017-08-15 Ethicon Endo-Surgery, Llc Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US9743929B2 (en) 2014-03-26 2017-08-29 Ethicon Llc Modular powered surgical instrument with detachable shaft assemblies
US9757123B2 (en) 2007-01-10 2017-09-12 Ethicon Llc Powered surgical instrument having a transmission system
US9795384B2 (en) 2013-03-27 2017-10-24 Ethicon Llc Fastener cartridge comprising a tissue thickness compensator and a gap setting element
US9795382B2 (en) 2005-08-31 2017-10-24 Ethicon Llc Fastener cartridge assembly comprising a cam and driver arrangement
US9801627B2 (en) 2014-09-26 2017-10-31 Ethicon Llc Fastener cartridge for creating a flexible staple line
US9801628B2 (en) 2014-09-26 2017-10-31 Ethicon Llc Surgical staple and driver arrangements for staple cartridges
US9808246B2 (en) 2015-03-06 2017-11-07 Ethicon Endo-Surgery, Llc Method of operating a powered surgical instrument
US9814462B2 (en) 2010-09-30 2017-11-14 Ethicon Llc Assembly for fastening tissue comprising a compressible layer
US9820738B2 (en) 2014-03-26 2017-11-21 Ethicon Llc Surgical instrument comprising interactive systems
US9820838B2 (en) 2012-04-10 2017-11-21 Ethicon, Inc. Single plane tissue repair patch
US9820837B2 (en) 2012-04-10 2017-11-21 Ethicon, Inc. Single plane tissue repair patch
US9820839B2 (en) 2012-04-10 2017-11-21 Ethicon, Inc. Single plane tissue repair patch having a locating structure
US9826978B2 (en) 2010-09-30 2017-11-28 Ethicon Llc End effectors with same side closure and firing motions
US9833241B2 (en) 2014-04-16 2017-12-05 Ethicon Llc Surgical fastener cartridges with driver stabilizing arrangements
US9839427B2 (en) 2005-08-31 2017-12-12 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and a staple driver arrangement
US9839420B2 (en) 2010-09-30 2017-12-12 Ethicon Llc Tissue thickness compensator comprising at least one medicament
US9844376B2 (en) 2014-11-06 2017-12-19 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US9844375B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Drive arrangements for articulatable surgical instruments
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US9861359B2 (en) 2006-01-31 2018-01-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US9895148B2 (en) 2015-03-06 2018-02-20 Ethicon Endo-Surgery, Llc Monitoring speed control and precision incrementing of motor for powered surgical instruments
US9895147B2 (en) 2005-11-09 2018-02-20 Ethicon Llc End effectors for surgical staplers
US9901342B2 (en) 2015-03-06 2018-02-27 Ethicon Endo-Surgery, Llc Signal and power communication system positioned on a rotatable shaft
US9913642B2 (en) 2014-03-26 2018-03-13 Ethicon Llc Surgical instrument comprising a sensor system
US9924961B2 (en) 2015-03-06 2018-03-27 Ethicon Endo-Surgery, Llc Interactive feedback system for powered surgical instruments
US9924944B2 (en) 2014-10-16 2018-03-27 Ethicon Llc Staple cartridge comprising an adjunct material
US9931118B2 (en) 2015-02-27 2018-04-03 Ethicon Endo-Surgery, Llc Reinforced battery for a surgical instrument
US9943309B2 (en) 2014-12-18 2018-04-17 Ethicon Llc Surgical instruments with articulatable end effectors and movable firing beam support arrangements
US9962161B2 (en) 2014-02-12 2018-05-08 Ethicon Llc Deliverable surgical instrument
US9987000B2 (en) 2014-12-18 2018-06-05 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US9993248B2 (en) 2015-03-06 2018-06-12 Ethicon Endo-Surgery, Llc Smart sensors with local signal processing
US9993258B2 (en) 2015-02-27 2018-06-12 Ethicon Llc Adaptable surgical instrument handle
US10004498B2 (en) 2006-01-31 2018-06-26 Ethicon Llc Surgical instrument comprising a plurality of articulation joints
US10045781B2 (en) 2014-06-13 2018-08-14 Ethicon Llc Closure lockout systems for surgical instruments
US10045776B2 (en) 2015-03-06 2018-08-14 Ethicon Llc Control techniques and sub-processor contained within modular shaft with select control processing from handle
US10052102B2 (en) 2015-06-18 2018-08-21 Ethicon Llc Surgical end effectors with dual cam actuated jaw closing features
US10052044B2 (en) 2015-03-06 2018-08-21 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10058963B2 (en) 2006-01-31 2018-08-28 Ethicon Llc Automated end effector component reloading system for use with a robotic system
US10076326B2 (en) 2015-09-23 2018-09-18 Ethicon Llc Surgical stapler having current mirror-based motor control
US10076325B2 (en) 2014-10-13 2018-09-18 Ethicon Llc Surgical stapling apparatus comprising a tissue stop
US10085748B2 (en) 2014-12-18 2018-10-02 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US10085751B2 (en) 2015-09-23 2018-10-02 Ethicon Llc Surgical stapler having temperature-based motor control
US10098642B2 (en) 2015-08-26 2018-10-16 Ethicon Llc Surgical staples comprising features for improved fastening of tissue
US10105139B2 (en) 2015-09-23 2018-10-23 Ethicon Llc Surgical stapler having downstream current-based motor control
US10117649B2 (en) 2014-12-18 2018-11-06 Ethicon Llc Surgical instrument assembly comprising a lockable articulation system
US10130359B2 (en) 2006-09-29 2018-11-20 Ethicon Llc Method for forming a staple
US10172620B2 (en) 2015-09-30 2019-01-08 Ethicon Llc Compressible adjuncts with bonding nodes
US10172619B2 (en) 2015-09-02 2019-01-08 Ethicon Llc Surgical staple driver arrays
US10180463B2 (en) 2015-02-27 2019-01-15 Ethicon Llc Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band
US10188385B2 (en) 2014-12-18 2019-01-29 Ethicon Llc Surgical instrument system comprising lockable systems
US10211586B2 (en) 2017-06-28 2019-02-19 Ethicon Llc Surgical shaft assemblies with watertight housings
US10206676B2 (en) 2008-02-14 2019-02-19 Ethicon Llc Surgical cutting and fastening instrument
US10213201B2 (en) 2015-03-31 2019-02-26 Ethicon Llc Stapling end effector configured to compensate for an uneven gap between a first jaw and a second jaw
US10226249B2 (en) 2013-03-01 2019-03-12 Ethicon Llc Articulatable surgical instruments with conductive pathways for signal communication
US10238386B2 (en) 2015-09-23 2019-03-26 Ethicon Llc Surgical stapler having motor control based on an electrical parameter related to a motor current
US10245033B2 (en) 2015-03-06 2019-04-02 Ethicon Llc Surgical instrument comprising a lockable battery housing
US10245030B2 (en) 2016-02-09 2019-04-02 Ethicon Llc Surgical instruments with tensioning arrangements for cable driven articulation systems
US10258331B2 (en) 2016-02-12 2019-04-16 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10258333B2 (en) 2012-06-28 2019-04-16 Ethicon Llc Surgical fastening apparatus with a rotary end effector drive shaft for selective engagement with a motorized drive system
US10258418B2 (en) 2017-06-29 2019-04-16 Ethicon Llc System for controlling articulation forces
US10258336B2 (en) 2008-09-19 2019-04-16 Ethicon Llc Stapling system configured to produce different formed staple heights
US10265065B2 (en) 2013-12-23 2019-04-23 Ethicon Llc Surgical staples and staple cartridges
US10265068B2 (en) 2015-12-30 2019-04-23 Ethicon Llc Surgical instruments with separable motors and motor control circuits
US10278780B2 (en) 2007-01-10 2019-05-07 Ethicon Llc Surgical instrument for use with robotic system
USD847989S1 (en) 2016-06-24 2019-05-07 Ethicon Llc Surgical fastener cartridge
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
USD850617S1 (en) 2016-06-24 2019-06-04 Ethicon Llc Surgical fastener cartridge
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10314589B2 (en) 2006-06-27 2019-06-11 Ethicon Llc Surgical instrument including a shifting assembly
USD851762S1 (en) 2017-06-28 2019-06-18 Ethicon Llc Anvil
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US10335148B2 (en) 2015-06-17 2019-07-02 Ethicon Llc Staple cartridge including a tissue thickness compensator for a surgical stapler

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090099579A1 (en) 2007-10-16 2009-04-16 Tyco Healthcare Group Lp Self-adherent implants and methods of preparation
EP2219620B1 (en) 2007-11-13 2017-07-19 Surmodics, Inc. Viscous terpolymers as drug delivery platform
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US8758373B2 (en) 2008-02-18 2014-06-24 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
WO2009104182A2 (en) 2008-02-18 2009-08-27 Polytouch Medical Ltd A device and method for deploying and attaching a patch to a biological tissue
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US9415197B2 (en) 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US8951546B2 (en) 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
CA2748296C (en) * 2008-12-23 2017-03-21 Surmodics Pharmaceuticals, Inc. Implantable composites and compositions comprising releasable bioactive agents
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
AU2010286116B2 (en) 2009-08-17 2014-06-26 Covidien Lp Means and method for reversibly connecting an implant to a deployment device
WO2012030822A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Process for reducing moisture in a biodegradable implant device
US9220586B2 (en) 2012-09-28 2015-12-29 Covidien Lp Surgical implant and applicator
CN106572920A (en) * 2014-03-14 2017-04-19 奥西里斯治疗公司 Support and packaging for membranes
CN107583631B (en) * 2017-09-11 2019-03-15 济南大学 A kind of preparation method of the porous cotton complex microsphere of dimercaprol dimercaptopropanol modified magnetic

Citations (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3612265A (en) * 1969-03-10 1971-10-12 Minnesota Mining & Mfg Adhesive bandage and envelope
US3636956A (en) * 1970-05-13 1972-01-25 Ethicon Inc Polylactide sutures
US3797499A (en) * 1970-05-13 1974-03-19 Ethicon Inc Polylactide fabric graphs for surgical implantation
US3861985A (en) * 1973-10-31 1975-01-21 Thomas J Parlagreco Bandage storage and dispensing container
US4394904A (en) * 1981-01-12 1983-07-26 Minnesota Mining And Manufacturing Company Peripherally supported package for adhesive-surfaced articles
US4655221A (en) * 1985-05-06 1987-04-07 American Cyanamid Company Method of using a surgical repair mesh
US5114421A (en) * 1986-09-22 1992-05-19 Polak Robert B Medicament container/dispenser assembly
US5292328A (en) * 1991-10-18 1994-03-08 United States Surgical Corporation Polypropylene multifilament warp knitted mesh and its use in surgery
US5333753A (en) * 1993-12-06 1994-08-02 The Kendall Company Finger bandage package and dispenser
US5341815A (en) * 1993-03-25 1994-08-30 Ethicon, Inc. Endoscopic surgical pouch
US5593441A (en) * 1992-03-04 1997-01-14 C. R. Bard, Inc. Method for limiting the incidence of postoperative adhesions
US5722943A (en) * 1985-03-01 1998-03-03 Ferris Mfg. Corporation Non-stretching wound dressing
US5844016A (en) * 1995-03-23 1998-12-01 Focal, Inc. Redox and photoinitiator priming for improved adherence of gels to substrates
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US5972008A (en) * 1998-04-29 1999-10-26 Kalinski; Robert J. Method and apparatus for retaining a surgical mesh
US6042592A (en) * 1997-08-04 2000-03-28 Meadox Medicals, Inc. Thin soft tissue support mesh
US6090116A (en) * 1997-10-03 2000-07-18 D'aversa; Margaret M. Knitted surgical mesh
US6287316B1 (en) * 1999-03-26 2001-09-11 Ethicon, Inc. Knitted surgical mesh
US20010046518A1 (en) * 1998-08-14 2001-11-29 Amarpreet S. Sawhney Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US20020045919A1 (en) * 1996-06-05 2002-04-18 Gunilla Johansson-Ruden Biocompatible glue
US20020049503A1 (en) * 2000-10-20 2002-04-25 Michael Milbocker Surgical repair of tissue defects
US6410044B1 (en) * 1998-03-19 2002-06-25 Surmodics, Inc. Crosslinkable macromers
US20020111652A1 (en) * 1992-06-02 2002-08-15 General Surgical Innovations, Inc. Apparatus and method for developing an anatomic space for laparoscopic hernia repair and patch for use therewith
US20030009181A1 (en) * 2001-03-09 2003-01-09 Gellman Barry N. System for implanting an implant and method thereof
US20030035786A1 (en) * 1999-11-04 2003-02-20 Medtronic, Inc. Biological tissue adhesives, articles, and methods
US20030045774A1 (en) * 2001-01-23 2003-03-06 Staskin David R. Sling delivery system and method of use
US6540764B1 (en) * 1992-06-02 2003-04-01 General Surgical Innovations, Inc. Apparatus and method for dissecting tissue layers
US6541678B2 (en) * 1999-09-27 2003-04-01 Brennen Medical, Inc. Immunostimulating coating for surgical devices
US20030074041A1 (en) * 2001-10-12 2003-04-17 Parry Andrew J. Implantable medical electrical lead with light-activated adhesive fixation
US20030171823A1 (en) * 2000-05-05 2003-09-11 Zotti Gian Carlo Anatomical double layer mesh for surgery
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6638284B1 (en) * 1999-06-08 2003-10-28 Ethicon, Inc. Knitted surgical mesh
US20030212461A1 (en) * 2002-05-10 2003-11-13 Valerie Vadurro Prosthetic repair fabric with erosion resistant edge
US20030212462A1 (en) * 2002-05-10 2003-11-13 Gryska Paul Vonryll Prosthetic repair fabric
US20040019360A1 (en) * 2002-07-25 2004-01-29 Farnsworth Ted R. Tissue repair device with a removable support member
US6689803B2 (en) * 1996-12-02 2004-02-10 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating surgical adhesions
US6736823B2 (en) * 2002-05-10 2004-05-18 C.R. Bard, Inc. Prosthetic repair fabric
US6755867B2 (en) * 2000-03-31 2004-06-29 Ethicon, Inc. Hernia repair prosthesis and method
US20040146546A1 (en) * 2002-09-26 2004-07-29 Angiotech Pharmaceuticals, Inc. Perivascular wraps
US6803069B2 (en) * 1996-09-13 2004-10-12 Scimed Life Systems, Inc. Method for imparting a bio-active coating
US20040202625A1 (en) * 2003-04-10 2004-10-14 Daniloff George Y. Compositions and methods of using a transient colorant
US20040215231A1 (en) * 2000-02-03 2004-10-28 David Fortune Device for the closure of a surgical puncture
US20050004599A1 (en) * 2003-06-30 2005-01-06 Mcnally-Heintzelman Karen M. Non-light activated adhesive composite, system, and methods of use thereof
US20050010078A1 (en) * 2003-07-07 2005-01-13 Jamiolkowski Dennis D. Implantable surgical mesh having a lubricious coating
US6914169B1 (en) * 2000-05-19 2005-07-05 Hisamitsu Pharmaceutical., Inc. Patch agent
US20050153090A1 (en) * 2004-01-08 2005-07-14 Marchitto Kevin S. Adhesive laminates for rapid wound occlusion
US6939364B1 (en) * 2001-10-09 2005-09-06 Tissue Adhesive Technologies, Inc. Composite tissue adhesive
US20060025785A1 (en) * 2004-08-02 2006-02-02 Cully Edward H Tissue repair device with a bioabsorbable support member

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3568635A (en) * 1967-09-29 1971-03-09 Highland Lab Treated material dispenser
US3835834A (en) * 1972-02-24 1974-09-17 J Brown Culture transporter
US4590089A (en) * 1979-04-30 1986-05-20 Ndm Corporation Medical electrodes and dispensing conditioner therefor
US4279344A (en) * 1979-12-26 1981-07-21 Reynolds Metals Company Heat-sealable and peelable laminated packaging construction
US4447482A (en) * 1982-01-21 1984-05-08 Shur Medical Corporation Wound closure tape and applicator therefor
DE3630635A1 (en) * 1986-08-26 1988-03-17 Helmut Zanker Packaging and dispenser for medical swab rolls and bandaging material
US5219077A (en) * 1992-02-10 1993-06-15 Ethicon, Inc. Package for mesh onlay and attached mesh plug technical field
JP2542792B2 (en) * 1992-11-05 1996-10-09 ベクトン・ディッキンソン・アンド・カンパニー User - The operation type iontophoretic device
WO1998012243A1 (en) 1996-09-23 1998-03-26 Focal, Inc. Polymerizable biodegradable polymers including carbonate or dioxanone linkages
JPH1176367A (en) * 1997-09-01 1999-03-23 Material Eng Tech Lab Inc Container for medical treatment
CN1241528C (en) * 2000-02-18 2006-02-15 安杰洛·多塔 Sealed package for adhesive wound dressing, and apparatus therefore
DE10009623B4 (en) * 2000-03-01 2005-08-11 3M Espe Ag Apparatus for storing and dispensing a flowable substance and using this apparatus,
AU9109201A (en) * 2000-09-18 2002-03-26 Organogenesis Inc Methods for treating a patient using a bioengineered flat sheet graft prostheses
US6779657B2 (en) * 2001-06-06 2004-08-24 Closure Medical Corporation Single-use applicators, dispensers and methods for polymerizable monomer compound
US7198150B1 (en) * 2001-07-18 2007-04-03 Biomet Manufacturing Corp. Device and method for hydrating and rehydrating orthopedic graft materials
US6547467B2 (en) * 2001-08-29 2003-04-15 Closure Medical Corporation Microapplicators, delivery systems and methods for adhesives and sealants
US7658279B2 (en) * 2002-02-14 2010-02-09 Otsuka Pharmaceutical Factory Inc. Medical multi-chamber container
JP4276814B2 (en) * 2002-04-11 2009-06-10 オリンパス株式会社 Bioabsorbable sheet
US20050208095A1 (en) 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
EP1861055A4 (en) * 2005-03-22 2013-01-16 Covidien Lp Bioactive wide-weave mesh
US7588548B2 (en) * 2005-04-22 2009-09-15 Kopreski Michael C Endothermic bandage with dispenser for the treatment of burns and other injuries
US20070074980A1 (en) * 2005-09-02 2007-04-05 Bankoski Brian R Implant rehydration packages and methods of use
US20070170080A1 (en) * 2006-01-26 2007-07-26 Joshua Stopek Medical device package
US20080077104A1 (en) * 2006-09-22 2008-03-27 Baer Noah J Absorbent article wrapper component having disposal means
US8118508B2 (en) * 2006-11-30 2012-02-21 Closure Medical Corporation Dispenser with a frangible container and a rotating breaking member, for dispensing a polymerizable monomer adhesive
JP5059584B2 (en) * 2007-01-11 2012-10-24 日東電工株式会社 Patch package structure
US20080269710A1 (en) * 2007-04-27 2008-10-30 The Procter & Gamble Company Hygiene article having a wipe and powdered substrate combination
US8197844B2 (en) * 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US20090099579A1 (en) 2007-10-16 2009-04-16 Tyco Healthcare Group Lp Self-adherent implants and methods of preparation
US8517174B2 (en) * 2010-06-22 2013-08-27 Ethicon, Inc. Dispensing packages for medical devices having two components that are mechanically interlocked and methods therefor

Patent Citations (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3612265A (en) * 1969-03-10 1971-10-12 Minnesota Mining & Mfg Adhesive bandage and envelope
US3636956A (en) * 1970-05-13 1972-01-25 Ethicon Inc Polylactide sutures
US3797499A (en) * 1970-05-13 1974-03-19 Ethicon Inc Polylactide fabric graphs for surgical implantation
US3861985A (en) * 1973-10-31 1975-01-21 Thomas J Parlagreco Bandage storage and dispensing container
US4394904A (en) * 1981-01-12 1983-07-26 Minnesota Mining And Manufacturing Company Peripherally supported package for adhesive-surfaced articles
US5722943A (en) * 1985-03-01 1998-03-03 Ferris Mfg. Corporation Non-stretching wound dressing
US4655221A (en) * 1985-05-06 1987-04-07 American Cyanamid Company Method of using a surgical repair mesh
US5114421A (en) * 1986-09-22 1992-05-19 Polak Robert B Medicament container/dispenser assembly
US5292328A (en) * 1991-10-18 1994-03-08 United States Surgical Corporation Polypropylene multifilament warp knitted mesh and its use in surgery
US5593441A (en) * 1992-03-04 1997-01-14 C. R. Bard, Inc. Method for limiting the incidence of postoperative adhesions
US6540764B1 (en) * 1992-06-02 2003-04-01 General Surgical Innovations, Inc. Apparatus and method for dissecting tissue layers
US20020111652A1 (en) * 1992-06-02 2002-08-15 General Surgical Innovations, Inc. Apparatus and method for developing an anatomic space for laparoscopic hernia repair and patch for use therewith
US5341815A (en) * 1993-03-25 1994-08-30 Ethicon, Inc. Endoscopic surgical pouch
US5333753A (en) * 1993-12-06 1994-08-02 The Kendall Company Finger bandage package and dispenser
US20040234574A9 (en) * 1995-03-23 2004-11-25 Focal, Inc. Compliant tissue sealants
US5844016A (en) * 1995-03-23 1998-12-01 Focal, Inc. Redox and photoinitiator priming for improved adherence of gels to substrates
US20030104032A1 (en) * 1995-03-23 2003-06-05 Focal, Inc. Compliant tissue sealants
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US6217894B1 (en) * 1996-03-22 2001-04-17 Focal, Inc. Compliant tissue sealants
US20010000728A1 (en) * 1996-03-22 2001-05-03 Sawhney Amapreet S. Compliant tissue sealants
US6531147B2 (en) * 1996-03-22 2003-03-11 Focal, Inc. Compliant tissue sealants
US6352710B2 (en) * 1996-03-22 2002-03-05 Focal, Inc. Compliant tissue sealants
US20020127266A1 (en) * 1996-03-22 2002-09-12 Focal, Inc. Compliant tissue sealants
US20020045919A1 (en) * 1996-06-05 2002-04-18 Gunilla Johansson-Ruden Biocompatible glue
US6803069B2 (en) * 1996-09-13 2004-10-12 Scimed Life Systems, Inc. Method for imparting a bio-active coating
US6689803B2 (en) * 1996-12-02 2004-02-10 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating surgical adhesions
US6375662B1 (en) * 1997-08-04 2002-04-23 Scimed Life Systems, Inc. Thin soft tissue surgical support mesh
US6042592A (en) * 1997-08-04 2000-03-28 Meadox Medicals, Inc. Thin soft tissue support mesh
US6090116A (en) * 1997-10-03 2000-07-18 D'aversa; Margaret M. Knitted surgical mesh
US20030031697A1 (en) * 1998-03-19 2003-02-13 Chudzik Stephen J. Crosslinkable macromers
US6924370B2 (en) * 1998-03-19 2005-08-02 Surmodics, Inc. Crosslinkable macromers
US6410044B1 (en) * 1998-03-19 2002-06-25 Surmodics, Inc. Crosslinkable macromers
US5972008A (en) * 1998-04-29 1999-10-26 Kalinski; Robert J. Method and apparatus for retaining a surgical mesh
US20040009205A1 (en) * 1998-08-14 2004-01-15 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US20040033264A1 (en) * 1998-08-14 2004-02-19 Incept Llc Composite hydrogel drug delivery systems
US20010046518A1 (en) * 1998-08-14 2001-11-29 Amarpreet S. Sawhney Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6287316B1 (en) * 1999-03-26 2001-09-11 Ethicon, Inc. Knitted surgical mesh
US6638284B1 (en) * 1999-06-08 2003-10-28 Ethicon, Inc. Knitted surgical mesh
US6541678B2 (en) * 1999-09-27 2003-04-01 Brennen Medical, Inc. Immunostimulating coating for surgical devices
US20030035786A1 (en) * 1999-11-04 2003-02-20 Medtronic, Inc. Biological tissue adhesives, articles, and methods
US20040215231A1 (en) * 2000-02-03 2004-10-28 David Fortune Device for the closure of a surgical puncture
US6755867B2 (en) * 2000-03-31 2004-06-29 Ethicon, Inc. Hernia repair prosthesis and method
US20030171823A1 (en) * 2000-05-05 2003-09-11 Zotti Gian Carlo Anatomical double layer mesh for surgery
US6914169B1 (en) * 2000-05-19 2005-07-05 Hisamitsu Pharmaceutical., Inc. Patch agent
US20020049503A1 (en) * 2000-10-20 2002-04-25 Michael Milbocker Surgical repair of tissue defects
US20030045774A1 (en) * 2001-01-23 2003-03-06 Staskin David R. Sling delivery system and method of use
US6936052B2 (en) * 2001-03-09 2005-08-30 Boston Scientific Scimed, Inc. System for implanting an implant and method thereof
US20030009181A1 (en) * 2001-03-09 2003-01-09 Gellman Barry N. System for implanting an implant and method thereof
US6939364B1 (en) * 2001-10-09 2005-09-06 Tissue Adhesive Technologies, Inc. Composite tissue adhesive
US20030074041A1 (en) * 2001-10-12 2003-04-17 Parry Andrew J. Implantable medical electrical lead with light-activated adhesive fixation
US6736823B2 (en) * 2002-05-10 2004-05-18 C.R. Bard, Inc. Prosthetic repair fabric
US20040181288A1 (en) * 2002-05-10 2004-09-16 C.R. Bard, Inc. Prosthetic repair fabric
US20030212461A1 (en) * 2002-05-10 2003-11-13 Valerie Vadurro Prosthetic repair fabric with erosion resistant edge
US20030212462A1 (en) * 2002-05-10 2003-11-13 Gryska Paul Vonryll Prosthetic repair fabric
US6736854B2 (en) * 2002-05-10 2004-05-18 C. R. Bard, Inc. Prosthetic repair fabric with erosion resistant edge
US20040019360A1 (en) * 2002-07-25 2004-01-29 Farnsworth Ted R. Tissue repair device with a removable support member
US20040146546A1 (en) * 2002-09-26 2004-07-29 Angiotech Pharmaceuticals, Inc. Perivascular wraps
US20040202625A1 (en) * 2003-04-10 2004-10-14 Daniloff George Y. Compositions and methods of using a transient colorant
US20050004599A1 (en) * 2003-06-30 2005-01-06 Mcnally-Heintzelman Karen M. Non-light activated adhesive composite, system, and methods of use thereof
US20050010078A1 (en) * 2003-07-07 2005-01-13 Jamiolkowski Dennis D. Implantable surgical mesh having a lubricious coating
US20050153090A1 (en) * 2004-01-08 2005-07-14 Marchitto Kevin S. Adhesive laminates for rapid wound occlusion
US20060025785A1 (en) * 2004-08-02 2006-02-02 Cully Edward H Tissue repair device with a bioabsorbable support member

Cited By (376)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9510830B2 (en) 2004-07-28 2016-12-06 Ethicon Endo-Surgery, Llc Staple cartridge
US9844379B2 (en) 2004-07-28 2017-12-19 Ethicon Llc Surgical stapling instrument having a clearanced opening
US9737302B2 (en) 2004-07-28 2017-08-22 Ethicon Llc Surgical stapling instrument having a restraining member
US10314590B2 (en) 2004-07-28 2019-06-11 Ethicon Llc Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism
US10278702B2 (en) 2004-07-28 2019-05-07 Ethicon Llc Stapling system comprising a firing bar and a lockout
US10293100B2 (en) 2004-07-28 2019-05-21 Ethicon Llc Surgical stapling instrument having a medical substance dispenser
US9737303B2 (en) 2004-07-28 2017-08-22 Ethicon Llc Articulating surgical stapling instrument incorporating a two-piece E-beam firing mechanism
US9585663B2 (en) 2004-07-28 2017-03-07 Ethicon Endo-Surgery, Llc Surgical stapling instrument configured to apply a compressive pressure to tissue
US10292707B2 (en) 2004-07-28 2019-05-21 Ethicon Llc Articulating surgical stapling instrument incorporating a firing mechanism
US9603991B2 (en) 2004-07-28 2017-03-28 Ethicon Endo-Surgery, Llc Surgical stapling instrument having a medical substance dispenser
US9795382B2 (en) 2005-08-31 2017-10-24 Ethicon Llc Fastener cartridge assembly comprising a cam and driver arrangement
US10321909B2 (en) 2005-08-31 2019-06-18 Ethicon Llc Staple cartridge comprising a staple including deformable members
US9307988B2 (en) 2005-08-31 2016-04-12 Ethicon Endo-Surgery, Llc Staple cartridges for forming staples having differing formed staple heights
US9839427B2 (en) 2005-08-31 2017-12-12 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and a staple driver arrangement
US9561032B2 (en) 2005-08-31 2017-02-07 Ethicon Endo-Surgery, Llc Staple cartridge comprising a staple driver arrangement
US10245032B2 (en) 2005-08-31 2019-04-02 Ethicon Llc Staple cartridges for forming staples having differing formed staple heights
US10271846B2 (en) 2005-08-31 2019-04-30 Ethicon Llc Staple cartridge for use with a surgical stapler
US10271845B2 (en) 2005-08-31 2019-04-30 Ethicon Llc Fastener cartridge assembly comprising a cam and driver arrangement
US9844373B2 (en) 2005-08-31 2017-12-19 Ethicon Llc Fastener cartridge assembly comprising a driver row arrangement
US10159482B2 (en) 2005-08-31 2018-12-25 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
US10245035B2 (en) 2005-08-31 2019-04-02 Ethicon Llc Stapling assembly configured to produce different formed staple heights
US9848873B2 (en) 2005-08-31 2017-12-26 Ethicon Llc Fastener cartridge assembly comprising a driver and staple cavity arrangement
US10278697B2 (en) 2005-08-31 2019-05-07 Ethicon Llc Staple cartridge comprising a staple driver arrangement
US10070863B2 (en) 2005-08-31 2018-09-11 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil
US9592052B2 (en) 2005-08-31 2017-03-14 Ethicon Endo-Surgery, Llc Stapling assembly for forming different formed staple heights
US9326768B2 (en) 2005-08-31 2016-05-03 Ethicon Endo-Surgery, Llc Staple cartridges for forming staples having differing formed staple heights
US10149679B2 (en) 2005-11-09 2018-12-11 Ethicon Llc Surgical instrument comprising drive systems
US10028742B2 (en) 2005-11-09 2018-07-24 Ethicon Llc Staple cartridge comprising staples with different unformed heights
US9895147B2 (en) 2005-11-09 2018-02-20 Ethicon Llc End effectors for surgical staplers
US9968356B2 (en) 2005-11-09 2018-05-15 Ethicon Llc Surgical instrument drive systems
US10201363B2 (en) 2006-01-31 2019-02-12 Ethicon Llc Motor-driven surgical instrument
US9439649B2 (en) 2006-01-31 2016-09-13 Ethicon Endo-Surgery, Llc Surgical instrument having force feedback capabilities
US9451958B2 (en) 2006-01-31 2016-09-27 Ethicon Endo-Surgery, Llc Surgical instrument with firing actuator lockout
US9370358B2 (en) 2006-01-31 2016-06-21 Ethicon Endo-Surgery, Llc Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10004498B2 (en) 2006-01-31 2018-06-26 Ethicon Llc Surgical instrument comprising a plurality of articulation joints
US9861359B2 (en) 2006-01-31 2018-01-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US9517068B2 (en) 2006-01-31 2016-12-13 Ethicon Endo-Surgery, Llc Surgical instrument with automatically-returned firing member
US9326770B2 (en) 2006-01-31 2016-05-03 Ethicon Endo-Surgery, Llc Surgical instrument
US10058963B2 (en) 2006-01-31 2018-08-28 Ethicon Llc Automated end effector component reloading system for use with a robotic system
US10278722B2 (en) 2006-01-31 2019-05-07 Ethicon Llc Motor-driven surgical cutting and fastening instrument
US9326769B2 (en) 2006-01-31 2016-05-03 Ethicon Endo-Surgery, Llc Surgical instrument
US10010322B2 (en) 2006-01-31 2018-07-03 Ethicon Llc Surgical instrument
US10299817B2 (en) 2006-01-31 2019-05-28 Ethicon Llc Motor-driven fastening assembly
US10098636B2 (en) 2006-01-31 2018-10-16 Ethicon Llc Surgical instrument having force feedback capabilities
US10052099B2 (en) 2006-01-31 2018-08-21 Ethicon Llc Surgical instrument system comprising a firing system including a rotatable shaft and first and second actuation ramps
US10052100B2 (en) 2006-01-31 2018-08-21 Ethicon Llc Surgical instrument system configured to detect resistive forces experienced by a tissue cutting implement
US9320520B2 (en) 2006-01-31 2016-04-26 Ethicon Endo-Surgery, Inc. Surgical instrument system
US9113874B2 (en) 2006-01-31 2015-08-25 Ethicon Endo-Surgery, Inc. Surgical instrument system
US9492167B2 (en) 2006-03-23 2016-11-15 Ethicon Endo-Surgery, Llc Articulatable surgical device with rotary driven cutting member
US10064688B2 (en) 2006-03-23 2018-09-04 Ethicon Llc Surgical system with selectively articulatable end effector
US10070861B2 (en) 2006-03-23 2018-09-11 Ethicon Llc Articulatable surgical device
US9301759B2 (en) 2006-03-23 2016-04-05 Ethicon Endo-Surgery, Llc Robotically-controlled surgical instrument with selectively articulatable end effector
US10213262B2 (en) 2006-03-23 2019-02-26 Ethicon Llc Manipulatable surgical systems with selectively articulatable fastening device
US9402626B2 (en) 2006-03-23 2016-08-02 Ethicon Endo-Surgery, Llc Rotary actuatable surgical fastener and cutter
US10314589B2 (en) 2006-06-27 2019-06-11 Ethicon Llc Surgical instrument including a shifting assembly
US9179911B2 (en) 2006-09-29 2015-11-10 Ethicon Endo-Surgery, Inc. End effector for use with a surgical fastening instrument
US9706991B2 (en) 2006-09-29 2017-07-18 Ethicon Endo-Surgery, Inc. Staple cartridge comprising staples including a lateral base
US10130359B2 (en) 2006-09-29 2018-11-20 Ethicon Llc Method for forming a staple
US9408604B2 (en) 2006-09-29 2016-08-09 Ethicon Endo-Surgery, Llc Surgical instrument comprising a firing system including a compliant portion
US9603595B2 (en) 2006-09-29 2017-03-28 Ethicon Endo-Surgery, Llc Surgical instrument comprising an adjustable system configured to accommodate different jaw heights
US10172616B2 (en) 2006-09-29 2019-01-08 Ethicon Llc Surgical staple cartridge
US10206678B2 (en) 2006-10-03 2019-02-19 Ethicon Llc Surgical stapling instrument with lockout features to prevent advancement of a firing assembly unless an unfired surgical staple cartridge is operably mounted in an end effector portion of the instrument
US10278780B2 (en) 2007-01-10 2019-05-07 Ethicon Llc Surgical instrument for use with robotic system
US9757123B2 (en) 2007-01-10 2017-09-12 Ethicon Llc Powered surgical instrument having a transmission system
US9675355B2 (en) 2007-01-11 2017-06-13 Ethicon Llc Surgical stapling device with a curved end effector
US9999431B2 (en) 2007-01-11 2018-06-19 Ethicon Endo-Surgery, Llc Surgical stapling device having supports for a flexible drive mechanism
US9730692B2 (en) 2007-01-11 2017-08-15 Ethicon Llc Surgical stapling device with a curved staple cartridge
US9775613B2 (en) 2007-01-11 2017-10-03 Ethicon Llc Surgical stapling device with a curved end effector
US9655624B2 (en) 2007-01-11 2017-05-23 Ethicon Llc Surgical stapling device with a curved end effector
US9724091B2 (en) 2007-01-11 2017-08-08 Ethicon Llc Surgical stapling device
US9700321B2 (en) 2007-01-11 2017-07-11 Ethicon Llc Surgical stapling device having supports for a flexible drive mechanism
US9603598B2 (en) 2007-01-11 2017-03-28 Ethicon Endo-Surgery, Llc Surgical stapling device with a curved end effector
US9750501B2 (en) 2007-01-11 2017-09-05 Ethicon Endo-Surgery, Llc Surgical stapling devices having laterally movable anvils
US9757130B2 (en) 2007-02-28 2017-09-12 Ethicon Llc Stapling assembly for forming different formed staple heights
US9795381B2 (en) 2007-06-04 2017-10-24 Ethicon Endo-Surgery, Llc Robotically-controlled shaft based rotary drive systems for surgical instruments
US9585658B2 (en) 2007-06-04 2017-03-07 Ethicon Endo-Surgery, Llc Stapling systems
US10327765B2 (en) 2007-06-04 2019-06-25 Ethicon Llc Drive systems for surgical instruments
US9987003B2 (en) 2007-06-04 2018-06-05 Ethicon Llc Robotic actuator assembly
US9186143B2 (en) 2007-06-04 2015-11-17 Ethicon Endo-Surgery, Inc. Robotically-controlled shaft based rotary drive systems for surgical instruments
US9750498B2 (en) 2007-06-04 2017-09-05 Ethicon Endo Surgery, Llc Drive systems for surgical instruments
US10299787B2 (en) 2007-06-04 2019-05-28 Ethicon Llc Stapling system comprising rotary inputs
US9662110B2 (en) 2007-06-22 2017-05-30 Ethicon Endo-Surgery, Llc Surgical stapling instrument with an articulatable end effector
US9872682B2 (en) 2007-06-29 2018-01-23 Ethicon Llc Surgical stapling instrument having a releasable buttress material
US9289206B2 (en) 2007-06-29 2016-03-22 Ethicon Endo-Surgery, Llc Lateral securement members for surgical staple cartridges
US9901344B2 (en) 2008-02-14 2018-02-27 Ethicon Llc Stapling assembly
US10265067B2 (en) 2008-02-14 2019-04-23 Ethicon Llc Surgical instrument including a regulator and a control system
US10238385B2 (en) 2008-02-14 2019-03-26 Ethicon Llc Surgical instrument system for evaluating tissue impedance
US9522029B2 (en) 2008-02-14 2016-12-20 Ethicon Endo-Surgery, Llc Motorized surgical cutting and fastening instrument having handle based power source
US9084601B2 (en) 2008-02-14 2015-07-21 Ethicon Endo-Surgery, Inc. Detachable motor powered surgical instrument
US9867618B2 (en) 2008-02-14 2018-01-16 Ethicon Llc Surgical stapling apparatus including firing force regulation
US10004505B2 (en) 2008-02-14 2018-06-26 Ethicon Llc Detachable motor powered surgical instrument
US9877723B2 (en) 2008-02-14 2018-01-30 Ethicon Llc Surgical stapling assembly comprising a selector arrangement
US10238387B2 (en) 2008-02-14 2019-03-26 Ethicon Llc Surgical instrument comprising a control system
US9901346B2 (en) 2008-02-14 2018-02-27 Ethicon Llc Stapling assembly
US9498219B2 (en) 2008-02-14 2016-11-22 Ethicon Endo-Surgery, Llc Detachable motor powered surgical instrument
US9901345B2 (en) 2008-02-14 2018-02-27 Ethicon Llc Stapling assembly
US10206676B2 (en) 2008-02-14 2019-02-19 Ethicon Llc Surgical cutting and fastening instrument
US9962158B2 (en) 2008-02-14 2018-05-08 Ethicon Llc Surgical stapling apparatuses with lockable end effector positioning systems
US9211121B2 (en) 2008-02-14 2015-12-15 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus
US9204878B2 (en) 2008-02-14 2015-12-08 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
US10307163B2 (en) 2008-02-14 2019-06-04 Ethicon Llc Detachable motor powered surgical instrument
US9980729B2 (en) 2008-02-14 2018-05-29 Ethicon Endo-Surgery, Llc Detachable motor powered surgical instrument
US9999426B2 (en) 2008-02-14 2018-06-19 Ethicon Llc Detachable motor powered surgical instrument
US9095339B2 (en) 2008-02-14 2015-08-04 Ethicon Endo-Surgery, Inc. Detachable motor powered surgical instrument
US9872684B2 (en) 2008-02-14 2018-01-23 Ethicon Llc Surgical stapling apparatus including firing force regulation
US20090206125A1 (en) * 2008-02-15 2009-08-20 Ethicon Endo-Surgery, Inc. Packaging for attaching buttress material to a surgical stapling instrument
US9770245B2 (en) 2008-02-15 2017-09-26 Ethicon Llc Layer arrangements for surgical staple cartridges
US9585657B2 (en) 2008-02-15 2017-03-07 Ethicon Endo-Surgery, Llc Actuator for releasing a layer of material from a surgical end effector
US10258336B2 (en) 2008-09-19 2019-04-16 Ethicon Llc Stapling system configured to produce different formed staple heights
US10045778B2 (en) 2008-09-23 2018-08-14 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US10130361B2 (en) 2008-09-23 2018-11-20 Ethicon Llc Robotically-controller motorized surgical tool with an end effector
US10105136B2 (en) 2008-09-23 2018-10-23 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US9655614B2 (en) 2008-09-23 2017-05-23 Ethicon Endo-Surgery, Llc Robotically-controlled motorized surgical instrument with an end effector
US10238389B2 (en) 2008-09-23 2019-03-26 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US10149683B2 (en) 2008-10-10 2018-12-11 Ethicon Llc Powered surgical cutting and stapling apparatus with manually retractable firing system
US9370364B2 (en) 2008-10-10 2016-06-21 Ethicon Endo-Surgery, Llc Powered surgical cutting and stapling apparatus with manually retractable firing system
US20100318121A1 (en) * 2008-10-20 2010-12-16 PolyTouch Medical, Inc. Device and method for attaching an implant to biological tissue
US8888811B2 (en) * 2008-10-20 2014-11-18 Covidien Lp Device and method for attaching an implant to biological tissue
US9393015B2 (en) 2009-02-06 2016-07-19 Ethicon Endo-Surgery, Llc Motor driven surgical fastener device with cutting member reversing mechanism
US9486214B2 (en) 2009-02-06 2016-11-08 Ethicon Endo-Surgery, Llc Motor driven surgical fastener device with switching system configured to prevent firing initiation until activated
US9096367B2 (en) 2009-05-30 2015-08-04 Jiangsu Synecoun Medical Technology Co., Ltd. Product having bioresorbable carrier materials and packaging
WO2011055368A3 (en) * 2009-11-09 2011-07-14 Ionmed Ltd Plasma head for tissue welding
WO2011055368A2 (en) * 2009-11-09 2011-05-12 Ionmed Ltd Plasma head for tissue welding
US9060750B2 (en) 2009-11-09 2015-06-23 Ionmed Ltd. Plasma head for tissue welding
US9597075B2 (en) 2010-07-30 2017-03-21 Ethicon Endo-Surgery, Inc. Tissue acquisition arrangements and methods for surgical stapling devices
US9833236B2 (en) 2010-09-30 2017-12-05 Ethicon Llc Tissue thickness compensator for surgical staplers
US10123798B2 (en) 2010-09-30 2018-11-13 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US9566061B2 (en) 2010-09-30 2017-02-14 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a releasably attached tissue thickness compensator
US9700317B2 (en) 2010-09-30 2017-07-11 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a releasable tissue thickness compensator
US9572574B2 (en) 2010-09-30 2017-02-21 Ethicon Endo-Surgery, Llc Tissue thickness compensators comprising therapeutic agents
US9592050B2 (en) 2010-09-30 2017-03-14 Ethicon Endo-Surgery, Llc End effector comprising a distal tissue abutment member
US10136890B2 (en) 2010-09-30 2018-11-27 Ethicon Llc Staple cartridge comprising a variable thickness compressible portion
US10028743B2 (en) 2010-09-30 2018-07-24 Ethicon Llc Staple cartridge assembly comprising an implantable layer
US10149682B2 (en) 2010-09-30 2018-12-11 Ethicon Llc Stapling system including an actuation system
US9480476B2 (en) 2010-09-30 2016-11-01 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising resilient members
US9592053B2 (en) 2010-09-30 2017-03-14 Ethicon Endo-Surgery, Llc Staple cartridge comprising multiple regions
US9433419B2 (en) 2010-09-30 2016-09-06 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a plurality of layers
US9220500B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising structure to produce a resilient load
US9220501B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensators
US9232941B2 (en) 2010-09-30 2016-01-12 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a reservoir
US20120312860A1 (en) * 2010-09-30 2012-12-13 Xintian Ming Tissue stapler having a thickness compensator incorporating an anti-microbial agent
US10182819B2 (en) 2010-09-30 2019-01-22 Ethicon Llc Implantable layer assemblies
US9924947B2 (en) 2010-09-30 2018-03-27 Ethicon Llc Staple cartridge comprising a compressible portion
US9386988B2 (en) 2010-09-30 2016-07-12 Ethicon End-Surgery, LLC Retainer assembly including a tissue thickness compensator
US10194910B2 (en) 2010-09-30 2019-02-05 Ethicon Llc Stapling assemblies comprising a layer
US9272406B2 (en) 2010-09-30 2016-03-01 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a cutting member for releasing a tissue thickness compensator
US10213198B2 (en) 2010-09-30 2019-02-26 Ethicon Llc Actuator for releasing a tissue thickness compensator from a fastener cartridge
US9277919B2 (en) 2010-09-30 2016-03-08 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising fibers to produce a resilient load
US9358005B2 (en) 2010-09-30 2016-06-07 Ethicon Endo-Surgery, Llc End effector layer including holding features
US9282962B2 (en) 2010-09-30 2016-03-15 Ethicon Endo-Surgery, Llc Adhesive film laminate
US9301752B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising a plurality of capsules
US9788834B2 (en) 2010-09-30 2017-10-17 Ethicon Llc Layer comprising deployable attachment members
US9883861B2 (en) 2010-09-30 2018-02-06 Ethicon Llc Retainer assembly including a tissue thickness compensator
US9795383B2 (en) 2010-09-30 2017-10-24 Ethicon Llc Tissue thickness compensator comprising resilient members
US9301753B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Expandable tissue thickness compensator
US9307965B2 (en) * 2010-09-30 2016-04-12 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an anti-microbial agent
US9801634B2 (en) 2010-09-30 2017-10-31 Ethicon Llc Tissue thickness compensator for a surgical stapler
US10265074B2 (en) 2010-09-30 2019-04-23 Ethicon Llc Implantable layers for surgical stapling devices
US9861361B2 (en) 2010-09-30 2018-01-09 Ethicon Llc Releasable tissue thickness compensator and fastener cartridge having the same
US10265072B2 (en) 2010-09-30 2019-04-23 Ethicon Llc Surgical stapling system comprising an end effector including an implantable layer
US9314246B2 (en) 2010-09-30 2016-04-19 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent
US9808247B2 (en) 2010-09-30 2017-11-07 Ethicon Llc Stapling system comprising implantable layers
US9615826B2 (en) 2010-09-30 2017-04-11 Ethicon Endo-Surgery, Llc Multiple thickness implantable layers for surgical stapling devices
US9848875B2 (en) 2010-09-30 2017-12-26 Ethicon Llc Anvil layer attached to a proximal end of an end effector
US9320518B2 (en) 2010-09-30 2016-04-26 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an oxygen generating agent
US9814462B2 (en) 2010-09-30 2017-11-14 Ethicon Llc Assembly for fastening tissue comprising a compressible layer
US9332974B2 (en) 2010-09-30 2016-05-10 Ethicon Endo-Surgery, Llc Layered tissue thickness compensator
US10258332B2 (en) 2010-09-30 2019-04-16 Ethicon Llc Stapling system comprising an adjunct and a flowable adhesive
US9844372B2 (en) 2010-09-30 2017-12-19 Ethicon Llc Retainer assembly including a tissue thickness compensator
US10064624B2 (en) 2010-09-30 2018-09-04 Ethicon Llc End effector with implantable layer
US9629814B2 (en) 2010-09-30 2017-04-25 Ethicon Endo-Surgery, Llc Tissue thickness compensator configured to redistribute compressive forces
US9826978B2 (en) 2010-09-30 2017-11-28 Ethicon Llc End effectors with same side closure and firing motions
US9839420B2 (en) 2010-09-30 2017-12-12 Ethicon Llc Tissue thickness compensator comprising at least one medicament
US10258330B2 (en) 2010-09-30 2019-04-16 Ethicon Llc End effector including an implantable arrangement
US9833238B2 (en) 2010-09-30 2017-12-05 Ethicon Endo-Surgery, Llc Retainer assembly including a tissue thickness compensator
US9345477B2 (en) 2010-09-30 2016-05-24 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator comprising incorporating a hemostatic agent
US9833242B2 (en) 2010-09-30 2017-12-05 Ethicon Endo-Surgery, Llc Tissue thickness compensators
US9364233B2 (en) 2010-09-30 2016-06-14 Ethicon Endo-Surgery, Llc Tissue thickness compensators for circular surgical staplers
US8608775B2 (en) 2011-01-24 2013-12-17 Covidien Lp Two part tape adhesive for wound closure
US9241714B2 (en) 2011-04-29 2016-01-26 Ethicon Endo-Surgery, Inc. Tissue thickness compensator and method for making the same
US9211120B2 (en) 2011-04-29 2015-12-15 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a plurality of medicaments
US9351730B2 (en) 2011-04-29 2016-05-31 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising channels
US10117652B2 (en) 2011-04-29 2018-11-06 Ethicon Llc End effector comprising a tissue thickness compensator and progressively released attachment members
US9775614B2 (en) 2011-05-27 2017-10-03 Ethicon Endo-Surgery, Llc Surgical stapling instruments with rotatable staple deployment arrangements
US10231794B2 (en) 2011-05-27 2019-03-19 Ethicon Llc Surgical stapling instruments with rotatable staple deployment arrangements
US9913648B2 (en) 2011-05-27 2018-03-13 Ethicon Endo-Surgery, Llc Surgical system
US9271799B2 (en) 2011-05-27 2016-03-01 Ethicon Endo-Surgery, Llc Robotic surgical system with removable motor housing
US10071452B2 (en) 2011-05-27 2018-09-11 Ethicon Llc Automated end effector component reloading system for use with a robotic system
US10130366B2 (en) 2011-05-27 2018-11-20 Ethicon Llc Automated reloading devices for replacing used end effectors on robotic surgical systems
US10004506B2 (en) 2011-05-27 2018-06-26 Ethicon Llc Surgical system
US9707066B2 (en) 2011-08-30 2017-07-18 Boston Scientific Scimed, Inc. Materials and methods for securing bodily implants
US20130225918A1 (en) * 2011-08-30 2013-08-29 Boston Scientific Scimed, Inc. Materials and methods for securing bodily implants
US9198746B2 (en) * 2011-08-30 2015-12-01 Boston Scientific Scimed, Inc. Materials and methods for securing bodily implants
US9687237B2 (en) 2011-09-23 2017-06-27 Ethicon Endo-Surgery, Llc Staple cartridge including collapsible deck arrangement
US9592054B2 (en) 2011-09-23 2017-03-14 Ethicon Endo-Surgery, Llc Surgical stapler with stationary staple drivers
US20130178947A1 (en) * 2012-01-09 2013-07-11 Zimmer, Inc. Porous metal implants with bone cement
US9539095B2 (en) 2012-01-09 2017-01-10 Zimmer, Inc. Porous metal implants with bone cement
US9730697B2 (en) 2012-02-13 2017-08-15 Ethicon Endo-Surgery, Llc Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US9414838B2 (en) 2012-03-28 2016-08-16 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprised of a plurality of materials
US9307989B2 (en) 2012-03-28 2016-04-12 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorportating a hydrophobic agent
US9974538B2 (en) 2012-03-28 2018-05-22 Ethicon Llc Staple cartridge comprising a compressible layer
US9198662B2 (en) 2012-03-28 2015-12-01 Ethicon Endo-Surgery, Inc. Tissue thickness compensator having improved visibility
US9314247B2 (en) 2012-03-28 2016-04-19 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating a hydrophilic agent
US9320523B2 (en) 2012-03-28 2016-04-26 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising tissue ingrowth features
US9918716B2 (en) 2012-03-28 2018-03-20 Ethicon Llc Staple cartridge comprising implantable layers
US9517063B2 (en) 2012-03-28 2016-12-13 Ethicon Endo-Surgery, Llc Movable member for use with a tissue thickness compensator
US9724098B2 (en) 2012-03-28 2017-08-08 Ethicon Endo-Surgery, Llc Staple cartridge comprising an implantable layer
US9204880B2 (en) 2012-03-28 2015-12-08 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising capsules defining a low pressure environment
US9820838B2 (en) 2012-04-10 2017-11-21 Ethicon, Inc. Single plane tissue repair patch
US9820839B2 (en) 2012-04-10 2017-11-21 Ethicon, Inc. Single plane tissue repair patch having a locating structure
US9820837B2 (en) 2012-04-10 2017-11-21 Ethicon, Inc. Single plane tissue repair patch
US10064621B2 (en) 2012-06-15 2018-09-04 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US9101358B2 (en) 2012-06-15 2015-08-11 Ethicon Endo-Surgery, Inc. Articulatable surgical instrument comprising a firing drive
US9649111B2 (en) 2012-06-28 2017-05-16 Ethicon Endo-Surgery, Llc Replaceable clip cartridge for a clip applier
US9289256B2 (en) 2012-06-28 2016-03-22 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US9101385B2 (en) 2012-06-28 2015-08-11 Ethicon Endo-Surgery, Inc. Electrode connections for rotary driven surgical tools
US9907620B2 (en) 2012-06-28 2018-03-06 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US9408606B2 (en) 2012-06-28 2016-08-09 Ethicon Endo-Surgery, Llc Robotically powered surgical device with manually-actuatable reversing system
US9364230B2 (en) 2012-06-28 2016-06-14 Ethicon Endo-Surgery, Llc Surgical stapling instruments with rotary joint assemblies
US10258333B2 (en) 2012-06-28 2019-04-16 Ethicon Llc Surgical fastening apparatus with a rotary end effector drive shaft for selective engagement with a motorized drive system
US10159555B2 (en) * 2012-09-28 2018-12-25 Sofradim Production Packaging for a hernia repair device
US20150209129A1 (en) * 2012-09-28 2015-07-30 Sofradim Production Packaging for a Hernia Repair Device
US9386984B2 (en) 2013-02-08 2016-07-12 Ethicon Endo-Surgery, Llc Staple cartridge comprising a releasable cover
US9700309B2 (en) 2013-03-01 2017-07-11 Ethicon Llc Articulatable surgical instruments with conductive pathways for signal communication
US9554794B2 (en) 2013-03-01 2017-01-31 Ethicon Endo-Surgery, Llc Multiple processor motor control for modular surgical instruments
US9782169B2 (en) 2013-03-01 2017-10-10 Ethicon Llc Rotary powered articulation joints for surgical instruments
US10226249B2 (en) 2013-03-01 2019-03-12 Ethicon Llc Articulatable surgical instruments with conductive pathways for signal communication
US9468438B2 (en) 2013-03-01 2016-10-18 Eticon Endo-Surgery, LLC Sensor straightened end effector during removal through trocar
US10285695B2 (en) 2013-03-01 2019-05-14 Ethicon Llc Articulatable surgical instruments with conductive pathways
US9326767B2 (en) 2013-03-01 2016-05-03 Ethicon Endo-Surgery, Llc Joystick switch assemblies for surgical instruments
US9398911B2 (en) 2013-03-01 2016-07-26 Ethicon Endo-Surgery, Llc Rotary powered surgical instruments with multiple degrees of freedom
US9358003B2 (en) 2013-03-01 2016-06-07 Ethicon Endo-Surgery, Llc Electromechanical surgical device with signal relay arrangement
US9307986B2 (en) 2013-03-01 2016-04-12 Ethicon Endo-Surgery, Llc Surgical instrument soft stop
US10335144B2 (en) 2013-03-07 2019-07-02 Ethicon Llc Surgical instrument
US9345481B2 (en) 2013-03-13 2016-05-24 Ethicon Endo-Surgery, Llc Staple cartridge tissue thickness sensor system
US9687230B2 (en) 2013-03-14 2017-06-27 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US9629623B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgery, Llc Drive system lockout arrangements for modular surgical instruments
US9351727B2 (en) 2013-03-14 2016-05-31 Ethicon Endo-Surgery, Llc Drive train control arrangements for modular surgical instruments
US9888919B2 (en) 2013-03-14 2018-02-13 Ethicon Llc Method and system for operating a surgical instrument
US9808244B2 (en) 2013-03-14 2017-11-07 Ethicon Llc Sensor arrangements for absolute positioning system for surgical instruments
US9883860B2 (en) 2013-03-14 2018-02-06 Ethicon Llc Interchangeable shaft assemblies for use with a surgical instrument
US10238391B2 (en) 2013-03-14 2019-03-26 Ethicon Llc Drive train control arrangements for modular surgical instruments
US9332987B2 (en) 2013-03-14 2016-05-10 Ethicon Endo-Surgery, Llc Control arrangements for a drive member of a surgical instrument
US9629629B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgey, LLC Control systems for surgical instruments
US9351726B2 (en) 2013-03-14 2016-05-31 Ethicon Endo-Surgery, Llc Articulation control system for articulatable surgical instruments
US9332984B2 (en) 2013-03-27 2016-05-10 Ethicon Endo-Surgery, Llc Fastener cartridge assemblies
US9572577B2 (en) 2013-03-27 2017-02-21 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a tissue thickness compensator including openings therein
US9795384B2 (en) 2013-03-27 2017-10-24 Ethicon Llc Fastener cartridge comprising a tissue thickness compensator and a gap setting element
US9844368B2 (en) 2013-04-16 2017-12-19 Ethicon Llc Surgical system comprising first and second drive systems
US9814460B2 (en) 2013-04-16 2017-11-14 Ethicon Llc Modular motor driven surgical instruments with status indication arrangements
US9826976B2 (en) 2013-04-16 2017-11-28 Ethicon Llc Motor driven surgical instruments with lockable dual drive shafts
US9867612B2 (en) 2013-04-16 2018-01-16 Ethicon Llc Powered surgical stapler
US9649110B2 (en) 2013-04-16 2017-05-16 Ethicon Llc Surgical instrument comprising a closing drive and a firing drive operated from the same rotatable output
US9801626B2 (en) 2013-04-16 2017-10-31 Ethicon Llc Modular motor driven surgical instruments with alignment features for aligning rotary drive shafts with surgical end effector shafts
US10136887B2 (en) 2013-04-16 2018-11-27 Ethicon Llc Drive system decoupling arrangement for a surgical instrument
US10149680B2 (en) 2013-04-16 2018-12-11 Ethicon Llc Surgical instrument comprising a gap setting system
US9574644B2 (en) 2013-05-30 2017-02-21 Ethicon Endo-Surgery, Llc Power module for use with a surgical instrument
US9283054B2 (en) 2013-08-23 2016-03-15 Ethicon Endo-Surgery, Llc Interactive displays
US9445813B2 (en) 2013-08-23 2016-09-20 Ethicon Endo-Surgery, Llc Closure indicator systems for surgical instruments
US9775609B2 (en) 2013-08-23 2017-10-03 Ethicon Llc Tamper proof circuit for surgical instrument battery pack
US9987006B2 (en) 2013-08-23 2018-06-05 Ethicon Llc Shroud retention arrangement for sterilizable surgical instruments
US9510828B2 (en) 2013-08-23 2016-12-06 Ethicon Endo-Surgery, Llc Conductor arrangements for electrically powered surgical instruments with rotatable end effectors
US10201349B2 (en) 2013-08-23 2019-02-12 Ethicon Llc End effector detection and firing rate modulation systems for surgical instruments
US9808249B2 (en) 2013-08-23 2017-11-07 Ethicon Llc Attachment portions for surgical instrument assemblies
US9700310B2 (en) 2013-08-23 2017-07-11 Ethicon Llc Firing member retraction devices for powered surgical instruments
US9924942B2 (en) 2013-08-23 2018-03-27 Ethicon Llc Motor-powered articulatable surgical instruments
US10265065B2 (en) 2013-12-23 2019-04-23 Ethicon Llc Surgical staples and staple cartridges
US9962161B2 (en) 2014-02-12 2018-05-08 Ethicon Llc Deliverable surgical instrument
US9775608B2 (en) 2014-02-24 2017-10-03 Ethicon Llc Fastening system comprising a firing member lockout
US9884456B2 (en) 2014-02-24 2018-02-06 Ethicon Llc Implantable layers and methods for altering one or more properties of implantable layers for use with fastening instruments
US9839422B2 (en) 2014-02-24 2017-12-12 Ethicon Llc Implantable layers and methods for altering implantable layers for use with surgical fastening instruments
US9693777B2 (en) 2014-02-24 2017-07-04 Ethicon Llc Implantable layers comprising a pressed region
US9839423B2 (en) 2014-02-24 2017-12-12 Ethicon Llc Implantable layers and methods for modifying the shape of the implantable layers for use with a surgical fastening instrument
US9757124B2 (en) 2014-02-24 2017-09-12 Ethicon Llc Implantable layer assemblies
US10028761B2 (en) 2014-03-26 2018-07-24 Ethicon Llc Feedback algorithms for manual bailout systems for surgical instruments
US9733663B2 (en) 2014-03-26 2017-08-15 Ethicon Llc Power management through segmented circuit and variable voltage protection
US9730695B2 (en) 2014-03-26 2017-08-15 Ethicon Endo-Surgery, Llc Power management through segmented circuit
US9826977B2 (en) 2014-03-26 2017-11-28 Ethicon Llc Sterilization verification circuit
US10004497B2 (en) 2014-03-26 2018-06-26 Ethicon Llc Interface systems for use with surgical instruments
US9690362B2 (en) 2014-03-26 2017-06-27 Ethicon Llc Surgical instrument control circuit having a safety processor
US9743929B2 (en) 2014-03-26 2017-08-29 Ethicon Llc Modular powered surgical instrument with detachable shaft assemblies
US9750499B2 (en) 2014-03-26 2017-09-05 Ethicon Llc Surgical stapling instrument system
US10013049B2 (en) 2014-03-26 2018-07-03 Ethicon Llc Power management through sleep options of segmented circuit and wake up control
US9913642B2 (en) 2014-03-26 2018-03-13 Ethicon Llc Surgical instrument comprising a sensor system
US9804618B2 (en) 2014-03-26 2017-10-31 Ethicon Llc Systems and methods for controlling a segmented circuit
US10201364B2 (en) 2014-03-26 2019-02-12 Ethicon Llc Surgical instrument comprising a rotatable shaft
US10117653B2 (en) 2014-03-26 2018-11-06 Ethicon Llc Systems and methods for controlling a segmented circuit
US10136889B2 (en) 2014-03-26 2018-11-27 Ethicon Llc Systems and methods for controlling a segmented circuit
US9820738B2 (en) 2014-03-26 2017-11-21 Ethicon Llc Surgical instrument comprising interactive systems
US9877721B2 (en) 2014-04-16 2018-01-30 Ethicon Llc Fastener cartridge comprising tissue control features
US10327776B2 (en) 2014-04-16 2019-06-25 Ethicon Llc Surgical stapling buttresses and adjunct materials
US9844369B2 (en) 2014-04-16 2017-12-19 Ethicon Llc Surgical end effectors with firing element monitoring arrangements
US9833241B2 (en) 2014-04-16 2017-12-05 Ethicon Llc Surgical fastener cartridges with driver stabilizing arrangements
US10299792B2 (en) 2014-04-16 2019-05-28 Ethicon Llc Fastener cartridge comprising non-uniform fasteners
US10010324B2 (en) 2014-04-16 2018-07-03 Ethicon Llc Fastener cartridge compromising fastener cavities including fastener control features
US10045781B2 (en) 2014-06-13 2018-08-14 Ethicon Llc Closure lockout systems for surgical instruments
US9724094B2 (en) 2014-09-05 2017-08-08 Ethicon Llc Adjunct with integrated sensors to quantify tissue compression
US10111679B2 (en) 2014-09-05 2018-10-30 Ethicon Llc Circuitry and sensors for powered medical device
US10016199B2 (en) 2014-09-05 2018-07-10 Ethicon Llc Polarity of hall magnet to identify cartridge type
US10135242B2 (en) 2014-09-05 2018-11-20 Ethicon Llc Smart cartridge wake up operation and data retention
US9737301B2 (en) 2014-09-05 2017-08-22 Ethicon Llc Monitoring device degradation based on component evaluation
US9788836B2 (en) 2014-09-05 2017-10-17 Ethicon Llc Multiple motor control for powered medical device
US9757128B2 (en) 2014-09-05 2017-09-12 Ethicon Llc Multiple sensors with one sensor affecting a second sensor's output or interpretation
US10327764B2 (en) 2014-09-26 2019-06-25 Ethicon Llc Method for creating a flexible staple line
US10206677B2 (en) 2014-09-26 2019-02-19 Ethicon Llc Surgical staple and driver arrangements for staple cartridges
US9801628B2 (en) 2014-09-26 2017-10-31 Ethicon Llc Surgical staple and driver arrangements for staple cartridges
US9801627B2 (en) 2014-09-26 2017-10-31 Ethicon Llc Fastener cartridge for creating a flexible staple line
US10076325B2 (en) 2014-10-13 2018-09-18 Ethicon Llc Surgical stapling apparatus comprising a tissue stop
US9924944B2 (en) 2014-10-16 2018-03-27 Ethicon Llc Staple cartridge comprising an adjunct material
US10052104B2 (en) 2014-10-16 2018-08-21 Ethicon Llc Staple cartridge comprising a tissue thickness compensator
US9844376B2 (en) 2014-11-06 2017-12-19 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US9987000B2 (en) 2014-12-18 2018-06-05 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US10245027B2 (en) 2014-12-18 2019-04-02 Ethicon Llc Surgical instrument with an anvil that is selectively movable about a discrete non-movable axis relative to a staple cartridge
US9844375B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Drive arrangements for articulatable surgical instruments
US10117649B2 (en) 2014-12-18 2018-11-06 Ethicon Llc Surgical instrument assembly comprising a lockable articulation system
US10004501B2 (en) 2014-12-18 2018-06-26 Ethicon Llc Surgical instruments with improved closure arrangements
US10188385B2 (en) 2014-12-18 2019-01-29 Ethicon Llc Surgical instrument system comprising lockable systems
US10085748B2 (en) 2014-12-18 2018-10-02 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US9968355B2 (en) 2014-12-18 2018-05-15 Ethicon Llc Surgical instruments with articulatable end effectors and improved firing beam support arrangements
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US9943309B2 (en) 2014-12-18 2018-04-17 Ethicon Llc Surgical instruments with articulatable end effectors and movable firing beam support arrangements
US9931118B2 (en) 2015-02-27 2018-04-03 Ethicon Endo-Surgery, Llc Reinforced battery for a surgical instrument
US9993258B2 (en) 2015-02-27 2018-06-12 Ethicon Llc Adaptable surgical instrument handle
US10159483B2 (en) 2015-02-27 2018-12-25 Ethicon Llc Surgical apparatus configured to track an end-of-life parameter
US10226250B2 (en) 2015-02-27 2019-03-12 Ethicon Llc Modular stapling assembly
US10182816B2 (en) 2015-02-27 2019-01-22 Ethicon Llc Charging system that enables emergency resolutions for charging a battery
US10321907B2 (en) 2015-02-27 2019-06-18 Ethicon Llc System for monitoring whether a surgical instrument needs to be serviced
US10180463B2 (en) 2015-02-27 2019-01-15 Ethicon Llc Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band
US10045779B2 (en) 2015-02-27 2018-08-14 Ethicon Llc Surgical instrument system comprising an inspection station
US10245028B2 (en) 2015-02-27 2019-04-02 Ethicon Llc Power adapter for a surgical instrument
US9901342B2 (en) 2015-03-06 2018-02-27 Ethicon Endo-Surgery, Llc Signal and power communication system positioned on a rotatable shaft
US10052044B2 (en) 2015-03-06 2018-08-21 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US9895148B2 (en) 2015-03-06 2018-02-20 Ethicon Endo-Surgery, Llc Monitoring speed control and precision incrementing of motor for powered surgical instruments
US9808246B2 (en) 2015-03-06 2017-11-07 Ethicon Endo-Surgery, Llc Method of operating a powered surgical instrument
US9993248B2 (en) 2015-03-06 2018-06-12 Ethicon Endo-Surgery, Llc Smart sensors with local signal processing
US10206605B2 (en) 2015-03-06 2019-02-19 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10245033B2 (en) 2015-03-06 2019-04-02 Ethicon Llc Surgical instrument comprising a lockable battery housing
US10045776B2 (en) 2015-03-06 2018-08-14 Ethicon Llc Control techniques and sub-processor contained within modular shaft with select control processing from handle
US9924961B2 (en) 2015-03-06 2018-03-27 Ethicon Endo-Surgery, Llc Interactive feedback system for powered surgical instruments
US10213201B2 (en) 2015-03-31 2019-02-26 Ethicon Llc Stapling end effector configured to compensate for an uneven gap between a first jaw and a second jaw
US10335148B2 (en) 2015-06-17 2019-07-02 Ethicon Llc Staple cartridge including a tissue thickness compensator for a surgical stapler
US10052102B2 (en) 2015-06-18 2018-08-21 Ethicon Llc Surgical end effectors with dual cam actuated jaw closing features
US10335150B2 (en) 2015-06-29 2019-07-02 Ethicon Llc Staple cartridge comprising an implantable layer
US10166026B2 (en) 2015-08-26 2019-01-01 Ethicon Llc Staple cartridge assembly including features for controlling the rotation of staples when being ejected therefrom
US10213203B2 (en) 2015-08-26 2019-02-26 Ethicon Llc Staple cartridge assembly without a bottom cover
US10188394B2 (en) 2015-08-26 2019-01-29 Ethicon Llc Staples configured to support an implantable adjunct
US10098642B2 (en) 2015-08-26 2018-10-16 Ethicon Llc Surgical staples comprising features for improved fastening of tissue
US10314587B2 (en) 2015-09-02 2019-06-11 Ethicon Llc Surgical staple cartridge with improved staple driver configurations
US10238390B2 (en) 2015-09-02 2019-03-26 Ethicon Llc Surgical staple cartridges with driver arrangements for establishing herringbone staple patterns
US10172619B2 (en) 2015-09-02 2019-01-08 Ethicon Llc Surgical staple driver arrays
US10251648B2 (en) 2015-09-02 2019-04-09 Ethicon Llc Surgical staple cartridge staple drivers with central support features
US10076326B2 (en) 2015-09-23 2018-09-18 Ethicon Llc Surgical stapler having current mirror-based motor control
US10238386B2 (en) 2015-09-23 2019-03-26 Ethicon Llc Surgical stapler having motor control based on an electrical parameter related to a motor current
US10085751B2 (en) 2015-09-23 2018-10-02 Ethicon Llc Surgical stapler having temperature-based motor control
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US10105139B2 (en) 2015-09-23 2018-10-23 Ethicon Llc Surgical stapler having downstream current-based motor control
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
US10327777B2 (en) 2015-09-30 2019-06-25 Ethicon Llc Implantable layer comprising plastically deformed fibers
US10172620B2 (en) 2015-09-30 2019-01-08 Ethicon Llc Compressible adjuncts with bonding nodes
US10285699B2 (en) 2015-09-30 2019-05-14 Ethicon Llc Compressible adjunct
US10271849B2 (en) 2015-09-30 2019-04-30 Ethicon Llc Woven constructs with interlocked standing fibers
US10307160B2 (en) 2015-09-30 2019-06-04 Ethicon Llc Compressible adjunct assemblies with attachment layers
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US10265068B2 (en) 2015-12-30 2019-04-23 Ethicon Llc Surgical instruments with separable motors and motor control circuits
US10245029B2 (en) 2016-02-09 2019-04-02 Ethicon Llc Surgical instrument with articulating and axially translatable end effector
US10245030B2 (en) 2016-02-09 2019-04-02 Ethicon Llc Surgical instruments with tensioning arrangements for cable driven articulation systems
US10258331B2 (en) 2016-02-12 2019-04-16 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
US10335151B2 (en) 2016-04-27 2019-07-02 Ethicon Llc Robotically-driven surgical instrument
USD847989S1 (en) 2016-06-24 2019-05-07 Ethicon Llc Surgical fastener cartridge
USD850617S1 (en) 2016-06-24 2019-06-04 Ethicon Llc Surgical fastener cartridge
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
USD851762S1 (en) 2017-06-28 2019-06-18 Ethicon Llc Anvil
US10211586B2 (en) 2017-06-28 2019-02-19 Ethicon Llc Surgical shaft assemblies with watertight housings
US10258418B2 (en) 2017-06-29 2019-04-16 Ethicon Llc System for controlling articulation forces

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EP2050474A3 (en) 2009-07-15
US20120279878A1 (en) 2012-11-08
US9241781B2 (en) 2016-01-26
CA2639472A1 (en) 2009-04-16
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US20160100927A1 (en) 2016-04-14
AU2008207394A1 (en) 2009-04-30
US10278802B2 (en) 2019-05-07
EP2436404B1 (en) 2016-07-27
EP2050474B1 (en) 2012-03-14
EP2436404A2 (en) 2012-04-04
ES2380410T3 (en) 2012-05-11

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