US20080287837A1 - Ultrasound medical system and method - Google Patents
Ultrasound medical system and method Download PDFInfo
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- US20080287837A1 US20080287837A1 US12/145,635 US14563508A US2008287837A1 US 20080287837 A1 US20080287837 A1 US 20080287837A1 US 14563508 A US14563508 A US 14563508A US 2008287837 A1 US2008287837 A1 US 2008287837A1
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- tissue
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- ultrasound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/06—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating caused by chemical reaction, e.g. moxaburners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/13—Tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
- A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
Definitions
- the present invention relates generally to ultrasound, and more particularly to ultrasound medical systems and methods.
- Known medical methods include using ultrasound imaging (at low power) of patients to identify patient tissue for medical treatment and include using ultrasound (at high power) to ablate identified patient tissue by heating the tissue.
- Known ultrasound medical systems and methods include deploying an ultrasound end effector having an ultrasound transducer outside the body to break up kidney stones inside the body, endoscopically inserting an ultrasound end effector having an ultrasound transducer in the rectum to medically destroy prostate cancer, laparoscopically inserting an ultrasound end effector having an ultrasound transducer in the abdominal cavity to medically destroy a cancerous liver tumor, intravenously inserting a catheter ultrasound end effector having an ultrasound transducer into a vein in the arm and moving the catheter to the heart to medically destroy diseased heart tissue, and interstitially inserting a needle ultrasound end effector having an ultrasound transducer needle into the tongue to medically destroy tissue to reduce tongue volume to reduce snoring.
- Rotatable ultrasound end effectors are known wherein an ultrasound transducer is non-rotatably attached to a shaft whose distal end is circumferentially and longitudinally surrounded by a sheath having a longitudinal axis and having an acoustic window. Water between the shaft and the sheath provides acoustic coupling between the ultrasound transducer and the acoustic window.
- the shaft is rotatable about the longitudinal axis with respect to the sheath.
- the sheath is non-rotatably attached to a handpiece.
- RF radio-frequency
- a method of the invention is for ultrasonically treating a lesion in a patient and includes steps a) through e).
- Step a) includes obtaining an interstitial end effector having a distal end, including a medical ultrasound transducer assembly having at least one medical-treatment ultrasound transducer, and including at least one end-effector-tissue-track ablation device.
- Step b) includes inserting the interstitial end effector into the patient creating a tissue track which is surrounded by patient tissue and which ends at the distal end of the inserted interstitial end effector.
- Step c) includes ultrasonically ablating the lesion using the at-least-one medical-treatment ultrasound transducer.
- Step d) includes using the at-least-one end-effector-tissue-track ablation device to ablate the patient tissue surrounding the tissue track along substantially the entire tissue track.
- Step e) includes withdrawing the end effector from the patient.
- An embodiment of the invention is an ultrasound medical system including an interstitial end effector.
- the interstitial end effector is interstitially insertable into patient tissue, includes at least one medical-treatment ultrasound transducer, and includes at least one end-effector-tissue-track ablation device.
- having an interstitial end effector with a medical-treatment ultrasound transducer and an end-effector-tissue-track ablation device allows ultrasonic ablation of a lesion using the medical-treatment ultrasound transducer and allows ablation of patient tissue surrounding the tissue track as the interstitial end effector is withdrawn from the patient to help reduce the possibility of excessive bleeding and/or tissue contamination.
- the present invention has, without limitation, application in conventional interstitial, endoscopic, laparoscopic, and open surgical instrumentation as well as application in robotic-assisted surgery.
- FIG. 1 is a perspective view of a first embodiment of the present invention showing an ultrasound medical system which includes an end effector, a handpiece, and a controller;
- FIG. 2 is a schematic cross-sectional view of a first embodiment of the end effector and the handpiece of the ultrasound medical system of FIG. 1 showing a medical ultrasound transducer assembly and two non-ultrasound tissue-property-measuring sensors;
- FIG. 3 is a view, as in FIG. 2 , but of a second embodiment of a handpiece and of an end effector having a medical ultrasound transducer assembly and two tines;
- FIG. 4 is a view, as in FIG. 2 , but of a third embodiment of an end effector having a medical ultrasound transducer assembly supported by a shaft and having a surrounding sheath, wherein the sheath includes two balloon portions;
- FIG. 5 is a block diagram view of a method of the invention for ultrasonically treating a lesion in a patient.
- FIG. 6 is a schematic view, partially in cross-section, of a fourth embodiment of an end effector which has a medical-treatment ultrasound transducer and three end-effector-tissue-track ablation devices and which can be used in one employment of the method of FIG. 5 .
- a first embodiment of the present invention is an ultrasound medical system 110 comprising an ultrasound end effector 112 and at least one non-ultrasound tissue-property-measuring sensor 114 and 116 .
- the ultrasound end effector 112 includes a medical ultrasound transducer assembly 118 having at least one medical-treatment ultrasound transducer 120 .
- the at-least-one non-ultrasound tissue-property-measuring sensor 114 and 116 is supported by the ultrasound end effector 112 and is disposable in contact with patient tissue 122 .
- a medical-treatment ultrasound transducer includes a medical-treatment-only ultrasound transducer and a medical-imaging-and-treatment ultrasound transducer.
- an ultrasound transducer has a single transducer element, and in another arrangement, an ultrasound transducer has a plurality (also called an array) of transducer elements.
- a medical ultrasound transducer assembly having at least one medical-treatment ultrasound transducer can also have at least one medical-imaging ultrasound transducer.
- the ultrasound end effector 112 includes a longitudinal axis 124 .
- the at-least-one non-ultrasound tissue-property-measuring sensor 114 and 116 includes a first non-ultrasound tissue-property-measuring sensor 114 and a second non-ultrasound tissue-property-measuring sensor 116 .
- the at-least-one medical-treatment ultrasound transducer 120 is disposed longitudinally between the first and second non-ultrasound tissue-property-measuring sensors 114 and 116 .
- the at-least-one non-ultrasound tissue-property-measuring sensor (e.g., 114 ) measures tissue temperature.
- the at-least-one non-ultrasound tissue-property-measuring sensor (e.g., 114 ) is chosen from the group consisting of a thermistor, a thermocouple, and combinations thereof.
- the at-least-one non-ultrasound tissue-property-measuring sensor e.g., 116 ) measures tissue electric impedance.
- the at-least-one non-ultrasound tissue-property-measuring sensor (e.g., 116 ) is chosen from the group consisting of a monopolar electrode, a bipolar electrode, and combinations thereof. It is noted that tissue temperature and/or tissue electric impedance is a measure of the degree of ultrasonic ablation of patient tissue, as can be appreciated by those skilled in the art.
- the ultrasound end effector 112 is an ultrasound interstitial end effector 126 which is interstitially insertable into patient tissue 122 and which has an exterior surface 128 .
- the at-least-one non-ultrasound tissue-property-measuring sensor 114 and 116 is attached to the ultrasound interstitial end effector 126 and is fixedly disposed substantially flush with the exterior surface 128 .
- the exterior surface 128 includes at least one balloon portion 130 and 132 which is expandable and contractible and which is expandable against patient tissue 122 to provide at least some stabilization of the ultrasound interstitial end effector 126 with respect to patient tissue 122 .
- the exterior surface 128 is the exterior surface of a sheath 134 and has first and second balloon portions 130 and 132 , wherein the first balloon portion 130 surrounds the medical ultrasound transducer assembly 118 and acts as an acoustic window, and wherein the second balloon portion 132 is longitudinally spaced apart from the medical ultrasound transducer assembly 118 .
- An acoustic coupling medium such as water, is disposable between the medical ultrasound transducer assembly 118 and the first balloon portion 130 and has been omitted from FIG. 2 for clarity.
- the first balloon portion 130 is omitted and the sheath 134 terminates before the medical ultrasound transducer assembly 118 which is exposed to patient tissue.
- the second balloon portion 132 is omitted.
- the at-least-one balloon portion 130 and 132 is contracted during tissue insertion and withdrawal of the ultrasound interstitial end effector 126 .
- Other constructions, arrangements, variations, and modifications are left to the artisan.
- the ultrasound end effector 112 is an ultrasound interstitial end effector 126 which is interstitially insertable into patient tissue 122 and which has an exterior surface 128 .
- the at-least-one non-ultrasound tissue-property-measuring sensor 114 and 116 is deployable to extend away from the exterior surface into patient tissue 128 to provide at least some stabilization of the ultrasound interstitial end effector 126 with respect to patient tissue 122 and is retrievable to retract back toward the exterior surface 128 .
- the at-least-one non-ultrasound tissue-property-measuring sensor 114 and 116 is storable inside the exterior surface.
- the ultrasound medical system 110 also includes a handpiece 136 operatively connected to the ultrasound end effector 112 ,
- the ultrasound end effector 112 has a longitudinal axis 124 and a shaft 138 , and the medical ultrasound transducer assembly 118 is supported by the shaft 138 .
- the shaft 138 is rotatable with respect to the handpiece 136 about the longitudinal axis 124 and is supported by bearings 139 .
- a motor 140 rotates the shaft 138 .
- the ultrasound medical system 110 includes a controller 142 operatively connected to the handpiece 136 via a cable 144 .
- a second embodiment of the present invention is an ultrasound medical system 210 comprising an ultrasound end effector 226 .
- the ultrasound end effector 226 has an exterior surface 228 .
- the ultrasound end effector 226 includes a medical ultrasound transducer assembly 218 having at least one medical-treatment ultrasound transducer 220 , and includes at least one tine 246 and 248 .
- the at-least-one tine 246 and 248 is deployable to extend away from the exterior surface into patient tissue to provide at least some stabilization of the ultrasound end effector 226 with respect to patient tissue and is retrievable to retract back toward the exterior surface 228 .
- the ultrasound end effector 226 is insertable into a patient.
- the ultrasound end effector 226 is an ultrasound interstitial end effector which is interstitially insertable into patient tissue.
- the ultrasound end effector is insertable into a patient in an endoscopic, laparoscopic, and/or open surgical manner.
- the ultrasound end effector is disposable on the outside of a patient. Other examples and variations are left to the artisan.
- the at-least-one tine 246 and 248 includes a plurality of tines.
- the at-least-one tine 246 and 248 is storable inside the exterior surface. It is noted that construction of deployable tines 246 and 248 in an ultrasound end effector 226 is within the level of skill of the artisan. In one arrangement, such deployment is accomplished using one or more of cables, levers, motors 249 , gearing, push rods and the like to move a tine partially out of, and back into, a lumen in the end effector. In one choice of materials, the tine comprises or consists essentially of Nitinol wire or nichrome wire.
- the at-least-one tine acts as an element chosen from the group consisting of an electrode, a thermistor, a thermocouple, an acoustic reflector, an acoustic absorber, an acoustic emitter, an acoustic receiver, a radio-frequency (RF) heater, a resistive heater, and combinations thereof.
- RF radio-frequency
- the at-least-one tine (e.g., 248 ) includes a component 250 chosen from the group consisting of an electrode, a thermistor, a thermocouple, an acoustic reflector, an acoustic absorber, an acoustic emitter, an acoustic receiver, a radio-frequency (RF) heater, a resistive heater, and combinations thereof.
- a component 250 chosen from the group consisting of an electrode, a thermistor, a thermocouple, an acoustic reflector, an acoustic absorber, an acoustic emitter, an acoustic receiver, a radio-frequency (RF) heater, a resistive heater, and combinations thereof.
- RF radio-frequency
- the exterior surface 228 is like the exterior surface 128 of a previously-illustrated and described construction of the embodiment of FIGS. 1-2 including at least one balloon portion which is expandable and contractible, and which is expandable against patient tissue to provide at least some stabilization of the ultrasound end effector with respect to patient tissue.
- the ultrasound medical system 210 also includes, like a previously-illustrated and described implementation of the embodiment of FIGS.
- a handpiece operatively connected to the ultrasound end effector, wherein the ultrasound end effector has a longitudinal axis and a shaft, wherein the medical ultrasound transducer assembly is supported by the shaft, and wherein the shaft is rotatable with respect to the handpiece about the longitudinal axis.
- Step a) includes obtaining the ultrasound medical system 210 .
- Step b) includes inserting the ultrasound end effector 226 into patient tissue.
- Step c) includes deploying the plurality of tines 246 and 248 to extend sway from the exterior surface 228 into the patient tissue.
- Step d) includes ultrasonically ablating the lesion using the at-least-one medical-treatment ultrasound transducer 220 .
- Step e) includes retrieving the plurality of tines 246 and 248 to retract back toward the exterior surface and storing the plurality of tines 246 and 248 inside the exterior surface 228 .
- Step f) includes withdrawing the ultrasound end effector 226 from the patient tissue.
- Another method also includes the step of employing the plurality of tines 246 and 248 to each act as the element or using each component 250 .
- An additional method also includes the step of expanding the at-least-one balloon portion against patient tissue and contracting the at-least-one balloon portion.
- a third embodiment of the present invention is an ultrasound medical system 310 comprising an ultrasound end effector 326 including a shaft 338 , a sheath 334 , and a medical ultrasound transducer assembly 318 .
- the medical ultrasound transducer assembly 318 is supported by the shaft 338 and has at least one medical-treatment ultrasound transducer 320 .
- the sheath 334 surrounds the shaft 338 .
- the sheath 334 includes at least one balloon portion 330 and 332 which is expandable against patient tissue to provide at least some stabilization of the ultrasound end effector 326 with respect to patient tissue.
- the ultrasound end effector 326 is insertable into a patient.
- the ultrasound end effector 326 is an ultrasound interstitial end effector which is interstitially insertable into patient tissue.
- the ultrasound end effector is insertable into a patient in an endoscopic, laparoscopic, and/or open surgical manner.
- the ultrasound end effector is disposable on the outside of a patient. Other examples and variations are left to the artisan.
- the ultrasound end effector 326 has a longitudinal axis 324 , and the at-least-one balloon portion (e.g., 330 ) acts as an acoustic window and is disposed to longitudinally overlap the at-least-one medical-treatment ultrasound transducer 320 .
- the at-least-one balloon portion e.g., 330
- the at-least-one balloon portion includes at least one through hole 352 .
- the at-least-one balloon portion (e.g., 330 ) includes a plurality of through holes 352 creating a “weeping” balloon portion, wherein some of the acoustic coupling medium inside the sheath 334 extends and/or flows outside the sheath acoustic window providing improved acoustic coupling between the at-least-one medical-treatment ultrasound transducer 320 and patient tissue.
- the at-least-one balloon portion (e.g., 330 ) includes at least one through hole 352 and the ultrasound end effector 326 is adapted to dispense a drug 354 through the at-least-one through hole 352 to patient tissue.
- the drug 354 is carried in a liquid acoustic coupling medium 356 , such as water, disposed between the medical ultrasound transducer assembly 318 and the at-least-one balloon portion 330 whose pressure is controlled (such as by a pump in a handpiece operatively connected to the ultrasound end effector) to expand and contract the at-least-one balloon portion 330 .
- the drug 354 is at least potentiated (i.e., has its medical effect increased and/or activated) by ultrasound emitted from the at-least-one medical-treatment ultrasound transducer 320 .
- the ultrasound end effector 326 has a longitudinal axis 324 , and the at-least-one balloon portion (e.g., 332 ) is disposed longitudinally apart from the at-least-one medical-treatment ultrasound transducer 320 .
- the at-least-one balloon portion e.g., 330
- the at-least-one balloon portion is a blister balloon portion.
- the at-least-one balloon portion is a blister balloon portion.
- the at-least-one balloon portion 330 and 332 includes an outside surface 358 having a roughness average at least equal to 0.005-inch.
- the outside surface includes ribs. Such surface roughness improves stabilization of the ultrasound end effector 326 with respect to patient tissue when the at-least-one balloon portion 330 and 332 is expanded against the patient tissue.
- the ultrasound medical system 310 also includes a controller, like the controller of the previously-illustrated and described arrangement of the embodiment of FIGS.
- the controller is operatively connected to the medical ultrasound transducer assembly, wherein the medical ultrasound transducer assembly is a medical-imaging-and-treatment ultrasound transducer assembly, and wherein the controller determines if the at-least-one balloon portion is acoustically coupled to, or acoustically decoupled from, patient tissue from ultrasonically imaging a balloon-tissue area using the medical-imaging-and-treatment ultrasound transducer assembly.
- Step a) is labeled as “Obtain Interstitial End Effector” in block 460 of FIG. 5 .
- Step a) includes obtaining an interstitial end effector 426 including a distal end 462 and including a medical ultrasound transducer assembly 418 having at least one medical-treatment ultrasound transducer 420 and at least one end-effector-tissue-track ablation device 472 , 474 and 476 .
- Step d) is labeled as “Ablate Tissue Track Using End Effector” in block 468 of FIG. 5 .
- Step d) includes using the at-least-one end-effector-tissue-track ablation device 472 , 474 and 476 to ablate the patient tissue surrounding the tissue track along substantially the entire tissue track.
- Step e) is labeled as “Withdraw End Effector” in block 470 of FIG. 5 .
- Step e) includes withdrawing the interstitial end effector 426 from the patient.
- interstitial end effector 426 is interstitially inserted into patient tissue. It is also noted that the interstitial end effector 426 can be equipped with a retractable tip shield (not shown) for initial endoscopic or laparoscopic patient entry followed by interstitial insertion into patient tissue.
- the step of using the at-least-one end-effector-tissue-track ablation device e.g., 474 .
- the at-least-one end-effector-tissue-track ablation device (e.g., 474 ) includes a non-ultrasound energy source, and step d) uses the non-ultrasound energy source to ablate the patient tissue surrounding the tissue track.
- the non-ultrasound energy source is chosen from the group consisting of a resistive heat energy source, a hot liquid energy source, a monopolar radio-frequency (RF) energy source, a bipolar radio-frequency (RF) energy source, a capacitive heat energy source, a microwave energy source, and combinations thereof.
- the at-least-one end-effector-tissue-track ablation device (e.g., 476 ) includes a tissue-ablating chemical agent, and step d) uses the tissue-ablating chemical agent to ablate the patient tissue surrounding the tissue track.
- the tissue-ablating chemical agent is chosen from the group consisting of fibrin, alcohol, an acidic fluid, a chemotherapeutic agent, and combinations thereof.
- step d) uses the medical ultrasound transducer assembly 418 to ultrasonically ablate the patient tissue surrounding the tissue track.
- step d) ultrasonically ablates at a higher ultrasound frequency than does step c).
- the step of monitoring (such as for acoustic coupling and/or for tissue ablation) the patient tissue surrounding the tissue track during step d).
- the monitoring is chosen from the group consisting of B-mode ultrasonic image monitoring, tissue temperature monitoring, tissue electric impedance, and combinations thereof.
- step b) and before step c) the step of stabilizing (such as by using a balloon, a tine and/or suction) the interstitial end effector 426 with respect to the patient tissue surrounding the tissue track and, after step c) and before step d), the step of releasing the stabilizing of the interstitial end effector 426 with respect to the patient tissue surrounding the tissue track.
- step e) includes stepwise withdrawing the interstitial end effector 426 from the patient using a plurality of positional steps
- step d) includes ablating the patient tissue surrounding the tissue track for a predetermined time with the interstitial end effector at each positional step.
- a fourth embodiment of the present invention is an ultrasound medical system 410 comprising an interstitial end effector 426 which is interstitially insertable into patient tissue, which includes at least one medical-treatment ultrasound transducer 420 , and which includes at least one end-effector-tissue-track ablation device 472 , 474 and 476 .
- the ultrasound medical system 410 includes a controller (such as the controller 142 illustrated in FIG. 1 ) which is operatively connected to the at-least-one medical-treatment ultrasound transducer 420 to ultrasonically ablate a lesion in patient tissue of the patient and which is operatively connected to the at-least-one end-effector-tissue-track ablation device 472 , 474 and 476 to ablate patient tissue surrounding the interstitial end effector 426 during withdrawal of the interstitial end effector 426 from the patient.
- a controller such as the controller 142 illustrated in FIG. 1
- the at-least-one medical-treatment ultrasound transducer 420 to ultrasonically ablate a lesion in patient tissue of the patient
- the at-least-one end-effector-tissue-track ablation device 472 , 474 and 476 to ablate patient tissue surrounding the interstitial end effector 426 during withdrawal of the interstitial end effector 426 from the patient.
- the at-least-one end-effector-tissue-track ablation device 472 , 474 , 476 includes a cylindrical ultrasound transducer 472 .
- the at-least-one end-effector-tissue-track ablation device and the at-least-one medical-treatment ultrasound transducer are a single rotatable ultrasound transducer (such as ultrasound transducer 420 made rotatable such as in a previously illustrated and described implementation of the embodiment of FIGS. 1-2 ).
- Other applications of an end-effector-tissue-track ablation device involving ultrasound are left to the artisan.
- the at-least-one end-effector-tissue-track ablation device 472 , 474 and 476 includes a device 474 which uses a non-ultrasound energy source.
- the non-ultrasound energy source is chosen from the group consisting of a resistive heat energy source, a hot liquid energy source, a monopolar radio-frequency (RF) energy source, a bipolar radio-frequency (RF) energy source, a capacitive heat energy source, a microwave energy source, and combinations thereof.
- the at-least-one end-effector-tissue-track ablation device 472 , 474 and 476 includes a device 476 which releases a tissue-ablating chemical agent.
- the tissue-ablating chemical agent is chosen from the group consisting of fibrin, alcohol, an acidic fluid, a chemotherapeutic agent, and combinations thereof.
- the interstitial end effector 426 has a length and an exterior surface 428 and includes position markings 478 on the exterior surface 428 along at least a portion of its length. Such position markings allow a user to withdraw the interstitial end effector 426 from patient tissue in positional steps while ablating patient tissue surrounding the end-effector tissue track for a predetermined dwell time at each positional step.
- the interstitial end effector 426 has a longitudinal axis 424 and a distal end 462 , and wherein the at-least-one end-effector-tissue-track ablation device 472 , 474 and 476 includes an end-effector-tissue-track ablation device (such as 474 ) which is disposed proximate the distal end 462 .
- the distal end of an interstitial end effector is an end having a tissue-piercing tip.
- the interstitial end effector 426 includes a tissue-ablating component (such as 474 ) adapted (such as by having a resistive heat energy source) to ablate (such as to thermally ablate) patient tissue longitudinally forward of the distal end 462 .
- a tissue-ablating component such as 474
- ablate such as to thermally ablate
- the ultrasound interstitial end effector includes a sheath 434 surrounding the medical-treatment ultrasound transducer 120 and having an acoustic window 480 .
- the entire sheath acts as an acoustic window.
- the acoustic window is a thinner portion of the sheath.
- the acoustic window is a separate material(s) from the material(s) of the non-acoustic-window portion(s) of the sheath. Acoustic window component materials are known to those skilled in the art. Other modifications are left to the artisan.
- having an interstitial end effector with a medical-treatment ultrasound transducer and an end-effector-tissue-track ablation device allows ultrasonic ablation of a lesion using the medical-treatment ultrasound transducer and allows ablation of patient tissue surrounding the tissue track as the interstitial end effector is withdrawn from the patient to help reduce the possibility of excessive bleeding and/or tissue contamination.
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Abstract
Description
- The present invention relates generally to ultrasound, and more particularly to ultrasound medical systems and methods.
- Known medical methods include using ultrasound imaging (at low power) of patients to identify patient tissue for medical treatment and include using ultrasound (at high power) to ablate identified patient tissue by heating the tissue.
- Known ultrasound medical systems and methods include deploying an ultrasound end effector having an ultrasound transducer outside the body to break up kidney stones inside the body, endoscopically inserting an ultrasound end effector having an ultrasound transducer in the rectum to medically destroy prostate cancer, laparoscopically inserting an ultrasound end effector having an ultrasound transducer in the abdominal cavity to medically destroy a cancerous liver tumor, intravenously inserting a catheter ultrasound end effector having an ultrasound transducer into a vein in the arm and moving the catheter to the heart to medically destroy diseased heart tissue, and interstitially inserting a needle ultrasound end effector having an ultrasound transducer needle into the tongue to medically destroy tissue to reduce tongue volume to reduce snoring.
- Rotatable ultrasound end effectors are known wherein an ultrasound transducer is non-rotatably attached to a shaft whose distal end is circumferentially and longitudinally surrounded by a sheath having a longitudinal axis and having an acoustic window. Water between the shaft and the sheath provides acoustic coupling between the ultrasound transducer and the acoustic window. The shaft is rotatable about the longitudinal axis with respect to the sheath. The sheath is non-rotatably attached to a handpiece.
- Known medical systems and methods include deploying a radio-frequency (RF) end effector having an RF electrode to thermally ablate patient tissue and to take tissue electric impedance and tissue temperature measurements using electrodes integrated into the shaft or into a tine which also helps stabilize the RF end effector in patient tissue.
- Still, scientists and engineers continue to seek improved ultrasound medical systems and methods.
- A method of the invention is for ultrasonically treating a lesion in a patient and includes steps a) through e). Step a) includes obtaining an interstitial end effector having a distal end, including a medical ultrasound transducer assembly having at least one medical-treatment ultrasound transducer, and including at least one end-effector-tissue-track ablation device. Step b) includes inserting the interstitial end effector into the patient creating a tissue track which is surrounded by patient tissue and which ends at the distal end of the inserted interstitial end effector. Step c) includes ultrasonically ablating the lesion using the at-least-one medical-treatment ultrasound transducer. Step d) includes using the at-least-one end-effector-tissue-track ablation device to ablate the patient tissue surrounding the tissue track along substantially the entire tissue track. Step e) includes withdrawing the end effector from the patient.
- An embodiment of the invention is an ultrasound medical system including an interstitial end effector. The interstitial end effector is interstitially insertable into patient tissue, includes at least one medical-treatment ultrasound transducer, and includes at least one end-effector-tissue-track ablation device.
- Several benefits and advantages are obtained from one or more of the embodiments and methods of the invention. In one example, having an interstitial end effector with a medical-treatment ultrasound transducer and an end-effector-tissue-track ablation device allows ultrasonic ablation of a lesion using the medical-treatment ultrasound transducer and allows ablation of patient tissue surrounding the tissue track as the interstitial end effector is withdrawn from the patient to help reduce the possibility of excessive bleeding and/or tissue contamination.
- The present invention has, without limitation, application in conventional interstitial, endoscopic, laparoscopic, and open surgical instrumentation as well as application in robotic-assisted surgery.
-
FIG. 1 is a perspective view of a first embodiment of the present invention showing an ultrasound medical system which includes an end effector, a handpiece, and a controller; -
FIG. 2 is a schematic cross-sectional view of a first embodiment of the end effector and the handpiece of the ultrasound medical system ofFIG. 1 showing a medical ultrasound transducer assembly and two non-ultrasound tissue-property-measuring sensors; -
FIG. 3 is a view, as inFIG. 2 , but of a second embodiment of a handpiece and of an end effector having a medical ultrasound transducer assembly and two tines; -
FIG. 4 is a view, as inFIG. 2 , but of a third embodiment of an end effector having a medical ultrasound transducer assembly supported by a shaft and having a surrounding sheath, wherein the sheath includes two balloon portions; -
FIG. 5 is a block diagram view of a method of the invention for ultrasonically treating a lesion in a patient; and -
FIG. 6 is a schematic view, partially in cross-section, of a fourth embodiment of an end effector which has a medical-treatment ultrasound transducer and three end-effector-tissue-track ablation devices and which can be used in one employment of the method ofFIG. 5 . - Before explaining the present invention in detail, it should be noted that the invention is not limited in its application or use to the details of construction and arrangement of parts and/or steps illustrated in the accompanying drawings and description. The illustrative embodiments and methods of the invention may be implemented or incorporated in other embodiments, methods, variations and modifications, and may be practiced or carried out in various ways. Furthermore, unless otherwise indicated, the terms and expressions employed herein have been chosen for the purpose of describing the illustrative embodiments and methods of the present invention for the convenience of the reader and are not for the purpose of limiting the invention.
- It is understood that any one or more of the following-described embodiments, methods, examples, etc. can be combined with any one or more of the other following-described embodiments, methods, examples, etc.
- Referring now to
FIGS. 1-2 of the drawings, a first embodiment of the present invention is an ultrasoundmedical system 110 comprising anultrasound end effector 112 and at least one non-ultrasound tissue-property-measuring sensor ultrasound end effector 112 includes a medicalultrasound transducer assembly 118 having at least one medical-treatment ultrasound transducer 120. The at-least-one non-ultrasound tissue-property-measuring sensor ultrasound end effector 112 and is disposable in contact withpatient tissue 122. - It is noted that a medical-treatment ultrasound transducer includes a medical-treatment-only ultrasound transducer and a medical-imaging-and-treatment ultrasound transducer. In one arrangement, an ultrasound transducer has a single transducer element, and in another arrangement, an ultrasound transducer has a plurality (also called an array) of transducer elements. It is also noted that a medical ultrasound transducer assembly having at least one medical-treatment ultrasound transducer can also have at least one medical-imaging ultrasound transducer.
- In one example of the embodiment of
FIGS. 1-2 , theultrasound end effector 112 includes alongitudinal axis 124. In this example, the at-least-one non-ultrasound tissue-property-measuring sensor measuring sensor 114 and a second non-ultrasound tissue-property-measuring sensor 116. The at-least-one medical-treatment ultrasound transducer 120 is disposed longitudinally between the first and second non-ultrasound tissue-property-measuring sensors - In one variation of the embodiment of
FIGS. 1-2 , the at-least-one non-ultrasound tissue-property-measuring sensor (e.g., 114) measures tissue temperature. In one modification, the at-least-one non-ultrasound tissue-property-measuring sensor (e.g., 114) is chosen from the group consisting of a thermistor, a thermocouple, and combinations thereof. In another variation, the at-least-one non-ultrasound tissue-property-measuring sensor (e.g., 116) measures tissue electric impedance. In one modification, the at-least-one non-ultrasound tissue-property-measuring sensor (e.g., 116) is chosen from the group consisting of a monopolar electrode, a bipolar electrode, and combinations thereof. It is noted that tissue temperature and/or tissue electric impedance is a measure of the degree of ultrasonic ablation of patient tissue, as can be appreciated by those skilled in the art. - In one construction of the embodiment of
FIGS. 1-2 , theultrasound end effector 112 is an ultrasoundinterstitial end effector 126 which is interstitially insertable intopatient tissue 122 and which has anexterior surface 128. The at-least-one non-ultrasound tissue-property-measuring sensor interstitial end effector 126 and is fixedly disposed substantially flush with theexterior surface 128. In one arrangement, theexterior surface 128 includes at least oneballoon portion patient tissue 122 to provide at least some stabilization of the ultrasoundinterstitial end effector 126 with respect topatient tissue 122. In one variation, theexterior surface 128 is the exterior surface of asheath 134 and has first andsecond balloon portions first balloon portion 130 surrounds the medicalultrasound transducer assembly 118 and acts as an acoustic window, and wherein thesecond balloon portion 132 is longitudinally spaced apart from the medicalultrasound transducer assembly 118. An acoustic coupling medium, such as water, is disposable between the medicalultrasound transducer assembly 118 and thefirst balloon portion 130 and has been omitted fromFIG. 2 for clarity. In one modification, thefirst balloon portion 130 is omitted and thesheath 134 terminates before the medicalultrasound transducer assembly 118 which is exposed to patient tissue. In another modification, thesecond balloon portion 132 is omitted. In one employment, the at-least-oneballoon portion interstitial end effector 126. Other constructions, arrangements, variations, and modifications are left to the artisan. - In one enablement of the embodiment of
FIGS. 1-2 , theultrasound end effector 112 is an ultrasoundinterstitial end effector 126 which is interstitially insertable intopatient tissue 122 and which has anexterior surface 128. In this enablement, the at-least-one non-ultrasound tissue-property-measuring sensor patient tissue 128 to provide at least some stabilization of the ultrasoundinterstitial end effector 126 with respect topatient tissue 122 and is retrievable to retract back toward theexterior surface 128. In one arrangement, the at-least-one non-ultrasound tissue-property-measuringsensor - In one implementation of the embodiment of
FIGS. 1-2 , the ultrasoundmedical system 110 also includes ahandpiece 136 operatively connected to theultrasound end effector 112, Theultrasound end effector 112 has alongitudinal axis 124 and ashaft 138, and the medicalultrasound transducer assembly 118 is supported by theshaft 138. Theshaft 138 is rotatable with respect to thehandpiece 136 about thelongitudinal axis 124 and is supported bybearings 139. In one variation, amotor 140 rotates theshaft 138. In one arrangement, the ultrasoundmedical system 110 includes acontroller 142 operatively connected to thehandpiece 136 via acable 144. - A second embodiment of the present invention, shown in
FIG. 3 , is an ultrasoundmedical system 210 comprising anultrasound end effector 226. Theultrasound end effector 226 has anexterior surface 228. Theultrasound end effector 226 includes a medicalultrasound transducer assembly 218 having at least one medical-treatment ultrasound transducer 220, and includes at least onetine tine ultrasound end effector 226 with respect to patient tissue and is retrievable to retract back toward theexterior surface 228. - In one example of the embodiment of
FIG. 3 , theultrasound end effector 226 is insertable into a patient. In one variation, theultrasound end effector 226 is an ultrasound interstitial end effector which is interstitially insertable into patient tissue. In other variations, the ultrasound end effector is insertable into a patient in an endoscopic, laparoscopic, and/or open surgical manner. In another example, the ultrasound end effector is disposable on the outside of a patient. Other examples and variations are left to the artisan. - In one enablement of the embodiment of
FIG. 3 , the at-least-onetine FIG. 3 , the at-least-onetine deployable tines ultrasound end effector 226 is within the level of skill of the artisan. In one arrangement, such deployment is accomplished using one or more of cables, levers,motors 249, gearing, push rods and the like to move a tine partially out of, and back into, a lumen in the end effector. In one choice of materials, the tine comprises or consists essentially of Nitinol wire or nichrome wire. - In one employment of the embodiment of
FIG. 3 , the at-least-one tine (e.g., 246) acts as an element chosen from the group consisting of an electrode, a thermistor, a thermocouple, an acoustic reflector, an acoustic absorber, an acoustic emitter, an acoustic receiver, a radio-frequency (RF) heater, a resistive heater, and combinations thereof. In another employment, the at-least-one tine (e.g., 248) includes acomponent 250 chosen from the group consisting of an electrode, a thermistor, a thermocouple, an acoustic reflector, an acoustic absorber, an acoustic emitter, an acoustic receiver, a radio-frequency (RF) heater, a resistive heater, and combinations thereof. - The embodiment, examples, constructions, implementations, etc. of the embodiment of
FIGS. 1-2 are equally applicable to the embodiment, constructions, implementations, etc. ofFIG. 3 . In one construction of the embodiment ofFIG. 3 , theexterior surface 228 is like theexterior surface 128 of a previously-illustrated and described construction of the embodiment ofFIGS. 1-2 including at least one balloon portion which is expandable and contractible, and which is expandable against patient tissue to provide at least some stabilization of the ultrasound end effector with respect to patient tissue. In one implementation of the embodiment ofFIG. 3 , the ultrasoundmedical system 210 also includes, like a previously-illustrated and described implementation of the embodiment ofFIGS. 1-2 , a handpiece operatively connected to the ultrasound end effector, wherein the ultrasound end effector has a longitudinal axis and a shaft, wherein the medical ultrasound transducer assembly is supported by the shaft, and wherein the shaft is rotatable with respect to the handpiece about the longitudinal axis. - One method, using the embodiment of
FIG. 3 and enablements, examples, employments, and constructions thereof, is for ultrasonically treating a lesion in a patient and includes steps a) through f). Step a) includes obtaining the ultrasoundmedical system 210. Step b) includes inserting theultrasound end effector 226 into patient tissue. Step c) includes deploying the plurality oftines exterior surface 228 into the patient tissue. Step d) includes ultrasonically ablating the lesion using the at-least-one medical-treatment ultrasound transducer 220. Step e) includes retrieving the plurality oftines tines exterior surface 228. Step f) includes withdrawing theultrasound end effector 226 from the patient tissue. Another method also includes the step of employing the plurality oftines component 250. An additional method also includes the step of expanding the at-least-one balloon portion against patient tissue and contracting the at-least-one balloon portion. - A third embodiment of the present invention, shown in
FIG. 4 , is an ultrasoundmedical system 310 comprising anultrasound end effector 326 including ashaft 338, asheath 334, and a medicalultrasound transducer assembly 318. The medicalultrasound transducer assembly 318 is supported by theshaft 338 and has at least one medical-treatment ultrasound transducer 320. Thesheath 334 surrounds theshaft 338. Thesheath 334 includes at least oneballoon portion ultrasound end effector 326 with respect to patient tissue. - In one example of the embodiment of
FIG. 4 , theultrasound end effector 326 is insertable into a patient. In one variation, theultrasound end effector 326 is an ultrasound interstitial end effector which is interstitially insertable into patient tissue. In other variations, the ultrasound end effector is insertable into a patient in an endoscopic, laparoscopic, and/or open surgical manner. In another example, the ultrasound end effector is disposable on the outside of a patient. Other examples and variations are left to the artisan. - In one construction of the embodiment of
FIG. 3 , theultrasound end effector 326 has alongitudinal axis 324, and the at-least-one balloon portion (e.g., 330) acts as an acoustic window and is disposed to longitudinally overlap the at-least-one medical-treatment ultrasound transducer 320. In one variation of this construction, the at-least-one balloon portion (e.g., 330) includes at least one throughhole 352. In one modification, the at-least-one balloon portion (e.g., 330) includes a plurality of throughholes 352 creating a “weeping” balloon portion, wherein some of the acoustic coupling medium inside thesheath 334 extends and/or flows outside the sheath acoustic window providing improved acoustic coupling between the at-least-one medical-treatment ultrasound transducer 320 and patient tissue. - In one arrangement of the embodiment of
FIG. 3 , the at-least-one balloon portion (e.g., 330) includes at least one throughhole 352 and theultrasound end effector 326 is adapted to dispense adrug 354 through the at-least-one throughhole 352 to patient tissue. In one variation, thedrug 354 is carried in a liquidacoustic coupling medium 356, such as water, disposed between the medicalultrasound transducer assembly 318 and the at-least-oneballoon portion 330 whose pressure is controlled (such as by a pump in a handpiece operatively connected to the ultrasound end effector) to expand and contract the at-least-oneballoon portion 330. In one variation, thedrug 354 is at least potentiated (i.e., has its medical effect increased and/or activated) by ultrasound emitted from the at-least-one medical-treatment ultrasound transducer 320. - In the same or another arrangement of the embodiment of
FIG. 3 , theultrasound end effector 326 has alongitudinal axis 324, and the at-least-one balloon portion (e.g., 332) is disposed longitudinally apart from the at-least-one medical-treatment ultrasound transducer 320. In one variation of the embodiment ofFIG. 3 , the at-least-one balloon portion (e.g., 330) is a fully-circumferential balloon portion. In a different variation, the at-least-one balloon portion (e.g., 332) is a blister balloon portion. In one example of the embodiment ofFIG. 3 , the at-least-oneballoon portion outside surface 358 having a roughness average at least equal to 0.005-inch. In one variation, the outside surface includes ribs. Such surface roughness improves stabilization of theultrasound end effector 326 with respect to patient tissue when the at-least-oneballoon portion - The embodiments, constructions, implementations, etc. of the embodiments of
FIGS. 1-2 and 3 are equally applicable to the embodiment, constructions, implementations, etc. of the embodiment ofFIG. 4 . In one implementation of the embodiment ofFIG. 3 , the ultrasoundmedical system 310 also includes a controller, like the controller of the previously-illustrated and described arrangement of the embodiment ofFIGS. 1-2 , wherein the controller is operatively connected to the medical ultrasound transducer assembly, wherein the medical ultrasound transducer assembly is a medical-imaging-and-treatment ultrasound transducer assembly, and wherein the controller determines if the at-least-one balloon portion is acoustically coupled to, or acoustically decoupled from, patient tissue from ultrasonically imaging a balloon-tissue area using the medical-imaging-and-treatment ultrasound transducer assembly. - One method of the invention for ultrasonically treating a lesion in a patient is shown in block diagram form in
FIG. 5 , and an embodiment of an ultrasound medical system which can be used in performing the method is shown inFIG. 6 . The method includes steps a) through e). Step a) is labeled as “Obtain Interstitial End Effector” inblock 460 ofFIG. 5 . Step a) includes obtaining aninterstitial end effector 426 including adistal end 462 and including a medicalultrasound transducer assembly 418 having at least one medical-treatment ultrasound transducer 420 and at least one end-effector-tissue-track ablation device block 464 ofFIG. 5 . Step b) includes inserting theinterstitial end effector 426 into the patient creating a tissue track which is surrounded by patient tissue and which ends at thedistal end 462 of the insertedinterstitial end effector 426. Step c) is labeled as “Ablate Lesion Using Ultrasound” inblock 466 ofFIG. 5 . Step c) includes ultrasonically ablating the lesion using the at-least-one medical-treatment ultrasound transducer 420. Step d) is labeled as “Ablate Tissue Track Using End Effector” inblock 468 ofFIG. 5 . Step d) includes using the at-least-one end-effector-tissue-track ablation device block 470 ofFIG. 5 . Step e) includes withdrawing theinterstitial end effector 426 from the patient. - It is noted that creating a tissue track requires that the
interstitial end effector 426 be interstitially inserted into patient tissue. It is also noted that theinterstitial end effector 426 can be equipped with a retractable tip shield (not shown) for initial endoscopic or laparoscopic patient entry followed by interstitial insertion into patient tissue. - In one extension of the method of
FIG. 5 , there is included the step of using the at-least-one end-effector-tissue-track ablation device (e.g., 474) to ablate the patient tissue at thedistal end 462 of the insertedinterstitial end effector 426. - In one implementation of the method of
FIG. 5 , the at-least-one end-effector-tissue-track ablation device (e.g., 474) includes a non-ultrasound energy source, and step d) uses the non-ultrasound energy source to ablate the patient tissue surrounding the tissue track. In one variation, the non-ultrasound energy source is chosen from the group consisting of a resistive heat energy source, a hot liquid energy source, a monopolar radio-frequency (RF) energy source, a bipolar radio-frequency (RF) energy source, a capacitive heat energy source, a microwave energy source, and combinations thereof. - In another implementation of the method, the at-least-one end-effector-tissue-track ablation device (e.g., 476) includes a tissue-ablating chemical agent, and step d) uses the tissue-ablating chemical agent to ablate the patient tissue surrounding the tissue track. In one variation, the tissue-ablating chemical agent is chosen from the group consisting of fibrin, alcohol, an acidic fluid, a chemotherapeutic agent, and combinations thereof.
- In a further implementation of the method, step d) uses the medical
ultrasound transducer assembly 418 to ultrasonically ablate the patient tissue surrounding the tissue track. In one variation, step d) ultrasonically ablates at a higher ultrasound frequency than does step c). - In the same or another extension of the method of
FIG. 5 , there is included the step of monitoring (such as for acoustic coupling and/or for tissue ablation) the patient tissue surrounding the tissue track during step d). In one variation, the monitoring is chosen from the group consisting of B-mode ultrasonic image monitoring, tissue temperature monitoring, tissue electric impedance, and combinations thereof. - In the same or another extension of the method of
FIG. 5 , there are included, after step b) and before step c), the step of stabilizing (such as by using a balloon, a tine and/or suction) theinterstitial end effector 426 with respect to the patient tissue surrounding the tissue track and, after step c) and before step d), the step of releasing the stabilizing of theinterstitial end effector 426 with respect to the patient tissue surrounding the tissue track. - In one application of the method of
FIG. 5 , step e) includes stepwise withdrawing theinterstitial end effector 426 from the patient using a plurality of positional steps, and step d) includes ablating the patient tissue surrounding the tissue track for a predetermined time with the interstitial end effector at each positional step. - A fourth embodiment of the present invention, shown in
FIG. 6 , is an ultrasoundmedical system 410 comprising aninterstitial end effector 426 which is interstitially insertable into patient tissue, which includes at least one medical-treatment ultrasound transducer 420, and which includes at least one end-effector-tissue-track ablation device - In one enablement of the embodiment of
FIG. 6 , the ultrasoundmedical system 410 includes a controller (such as thecontroller 142 illustrated inFIG. 1 ) which is operatively connected to the at-least-one medical-treatment ultrasound transducer 420 to ultrasonically ablate a lesion in patient tissue of the patient and which is operatively connected to the at-least-one end-effector-tissue-track ablation device interstitial end effector 426 during withdrawal of theinterstitial end effector 426 from the patient. - In one application of the embodiment of
FIG. 6 , the at-least-one end-effector-tissue-track ablation device cylindrical ultrasound transducer 472. In the same or a different application, the at-least-one end-effector-tissue-track ablation device and the at-least-one medical-treatment ultrasound transducer are a single rotatable ultrasound transducer (such asultrasound transducer 420 made rotatable such as in a previously illustrated and described implementation of the embodiment ofFIGS. 1-2 ). Other applications of an end-effector-tissue-track ablation device involving ultrasound are left to the artisan. - In another application of the embodiment of
FIG. 6 , the at-least-one end-effector-tissue-track ablation device device 474 which uses a non-ultrasound energy source. In one variation, the non-ultrasound energy source is chosen from the group consisting of a resistive heat energy source, a hot liquid energy source, a monopolar radio-frequency (RF) energy source, a bipolar radio-frequency (RF) energy source, a capacitive heat energy source, a microwave energy source, and combinations thereof. - In a further application of the embodiment of
FIG. 6 , the at-least-one end-effector-tissue-track ablation device device 476 which releases a tissue-ablating chemical agent. In one variation, the tissue-ablating chemical agent is chosen from the group consisting of fibrin, alcohol, an acidic fluid, a chemotherapeutic agent, and combinations thereof. - In one construction of the embodiment of
FIG. 6 , theinterstitial end effector 426 has a length and anexterior surface 428 and includesposition markings 478 on theexterior surface 428 along at least a portion of its length. Such position markings allow a user to withdraw theinterstitial end effector 426 from patient tissue in positional steps while ablating patient tissue surrounding the end-effector tissue track for a predetermined dwell time at each positional step. In the same or a different construction, theinterstitial end effector 426 has alongitudinal axis 424 and adistal end 462, and wherein the at-least-one end-effector-tissue-track ablation device distal end 462. It is noted that the distal end of an interstitial end effector is an end having a tissue-piercing tip. In the same or a different construction, theinterstitial end effector 426 includes a tissue-ablating component (such as 474) adapted (such as by having a resistive heat energy source) to ablate (such as to thermally ablate) patient tissue longitudinally forward of thedistal end 462. - In one variation, the ultrasound interstitial end effector includes a
sheath 434 surrounding the medical-treatment ultrasound transducer 120 and having anacoustic window 480. In one modification, the entire sheath acts as an acoustic window. In another modification, the acoustic window is a thinner portion of the sheath. In a further modification, the acoustic window is a separate material(s) from the material(s) of the non-acoustic-window portion(s) of the sheath. Acoustic window component materials are known to those skilled in the art. Other modifications are left to the artisan. - It is noted that the embodiments, constructions, implementations, etc. of the embodiments of
FIGS. 1-2 , 3 and 4 are equally applicable to the embodiment, constructions, implementations, etc. of the embodiment ofFIG. 6 . - Several benefits and advantages are obtained from one or more of the embodiments and method of the invention. In one example, having an interstitial end effector with a medical-treatment ultrasound transducer and an end-effector-tissue-track ablation device allows ultrasonic ablation of a lesion using the medical-treatment ultrasound transducer and allows ablation of patient tissue surrounding the tissue track as the interstitial end effector is withdrawn from the patient to help reduce the possibility of excessive bleeding and/or tissue contamination.
- While the present invention has been illustrated by a description of several embodiments and methods, it is not the intention of the applicants to restrict or limit the spirit and scope of the appended claims to such detail. Numerous other variations, changes, and substitutions will occur to those skilled in the art without departing from the scope of the invention. For instance, the ultrasound medical system of the invention has application in robotic assisted surgery taking into account the obvious modifications of such systems, components and methods to be compatible with such a robotic system. It will be understood that the foregoing description is provided by way of example, and that other modifications may occur to those skilled in the art without departing from the scope and spirit of the appended Claims.
Claims (13)
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US20130218013A1 (en) | 2013-08-22 |
US20050261611A1 (en) | 2005-11-24 |
US7473250B2 (en) | 2009-01-06 |
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