US20080182827A2 - Method for the treatment of acne - Google Patents

Method for the treatment of acne Download PDF

Info

Publication number
US20080182827A2
US20080182827A2 US11944186 US94418607A US2008182827A2 US 20080182827 A2 US20080182827 A2 US 20080182827A2 US 11944186 US11944186 US 11944186 US 94418607 A US94418607 A US 94418607A US 2008182827 A2 US2008182827 A2 US 2008182827A2
Authority
US
Grant status
Application
Patent type
Prior art keywords
oral
dosage form
minocycline
oral dosage
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11944186
Other versions
US20080070872A1 (en )
Inventor
Mitchell Wortzman
R. Plott
Kuljit Bhatia
Bhiku Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicis Pharmaceutical Corp
Original Assignee
Medicis Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines

Abstract

A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen.

Description

    CROSS REFERENCE TO RELATED APPLICATIONS
  • This application is a divisional of U.S. application Ser. No. 11/166,817 filed on Jun. 24, 2005 the entire disclosure of which is incorporated by reference in its entirety.
  • FIELD OF THE INVENTION
  • This invention relates to the treatment of acne vulgaris, commonly known simply as “acne.” Acne is a disease of the skin in which the pilosebaceous structures of the skin become inflamed, leading to the formation of comedones, pustules and nodules. Acne can lead to permanent scarring in severe cases.
  • It is generally believed that acne arises when hyperkeratosis of the pilosebaceous structure wholly or partially blocks the opening of the structure, resulting in comedones filled with sebum, keratin, and Propionibacterium acnes. These lesions are commonly identified as acne. P. acnes naturally occurs in normal skin, but is especially and characteristically present in acne lesions. It is believed that metabolic byproducts and waste from P. acnes within the pilosebaceous structures cause or contribute to the inflammation of acne lesions.
  • Conventional acne treatments have taken many forms. Topical keratolytic agents, such as salicylic acid are sometimes used. Keratolytic agents are thought to encourage the opening up of blocked pilosebaceous structures, thereby reducing conditions that are favorable to inflammation. Benzoyl peroxide, an anti-microbial, remains a popular and effective treatment. Topical antibiotics, such as clindamycin, which are effective against P. acnes, have also been used with a view towards preventing the formation of metabolic byproducts from this organism. Topical retinoids such as tretinoin have also been used in the treatment of acne.
  • Systemic (i.e. non-topical) treatments for acne include the use of oral antibiotics in more serious cases. These treatments are directed towards the reduction in the amount P. acnes in the skin, especially the pilosebaceous structures, and seek to reduce the inflammation caused by waste materials and metabolic byproducts from these organisms. Tetracycline antibiotics are most commonly used for this purpose. These include tetracycline, minocycline and doxycycline. Erythromycinis also sometimes used.
  • Standard oral minocycline therapy for acne in pediatric patients calls for the administration of a 4 mg/kg initial loading dose, and a 2 mg/kg dose every 12 hours thereafter. This results in a dose of 6 mg/kg on the first day of treatment and a 4 mg/kg dose each day thereafter. In adults, a 200 mg initial dose is followed by a 100 mg dose every 12 hours thereafter. In a typical patient, this results in about a 4.5 mg/kg dose on the first day of treatment, and 3.0 mg/kg dose each day thereafter.
  • In cases where acne does not respond to oral antibiotic treatment, oral isotretinoin is sometimes used. While effective, isotretinoin is also powerfully teratogenic, and women of childbearing age are required to use multiple methods of contraception while taking the drug.
  • While oral tetracycline antibiotics remain a highly favored and widely used treatment for more serious cases of acne, it is not without side effects. Vestibular side effects, including extreme dizziness and concomitant nausea, can be so severe as to result in discontinuance of tetracycline therapy. Long term use can sometimes result in vaginal candidisis, esophageal erosions and in antibiotic resistant infections.
  • Some recent research has indicated that very low doses of oral tetracycline can result in some improvement of acne even though the dose of tetracycline is too low to have an antibiotic effect. This observation has been attributed to an anti-inflammatory effect of tetracycline compounds. This effect has been reported to have been observed even where a chemically modified tetracycline that have no antibiotic properties are used. The use of tetracycline antibiotics at a dose too low to have an antibiotic effect or the use of modified tetracycline having no antibiotic properties as treatments for acne has never been approved by any drug regulatory agency.
  • SUMMARY OF THE INVENTION
  • According to the present invention, a method is provided for the treatment of acne in which an antibiotically effective dose of an oral tetracycline, such as minocycline, is provided. This dose is approximately 1 milligram per kilogram of body weight (1 mg/kg), without an initial loading dose of antibiotic. This antibiotic dosing regimen has been found to be as effective as a conventional dosing regimen incorporating a significant initial loading dose and higher subsequent doses. However, the dosing method of the current invention produces far fewer side effects.
  • In another aspect of this invention, the oral tetracycline is provided in a dosage form that provides for the continued release of the antibiotic between doses, as opposed to an immediate or nearly immediate release of the drug.
  • DETAILED DESCRIPTION OF THE INVENTION
  • According to the present invention, acne vulgaris is treated by the use of an oral tetracycline antibiotic, preferably minocycline. This antibiotic is administered in an antibiotically effective amount of approximately 1.0 milligram per kilogram of body weight per day (1.0 mg/kg/day). While this may be accomplished by the use of divided doses, it is preferred that the tetracycline antibiotic be delivered in a single daily dose. This treatment regime is initiated without a loading dose, and is continued until resolution or substantial resolution of the patient's acne. The course of treatment typically lasts 12 to up to 60 weeks, but will be adjusted according to the disease status and other medical conditions of each patient in the exercise of ordinary good clinical judgment by the patient's health care provider.
  • Controlled, double-blinded studies were undertaken to determine the effectiveness of this invention. Treatment of 473 patients with acne was undertaken according to the present invention. Placebos were provided to 239 patients. The effectiveness of the invention in treating acne vulgaris is shown in Table 1.
    TABLE 1
    Total Lesion Counts
    Total Lesions
    Total Lesions (as Percent of Baseline)
    Baseline (mean) 169.3 100
    Day 28 (mean) 134.0 78
    Day 56 (mean) 119.3 69
    Day 84 (mean) 112.3 66
    Inflammatory Lesion Counts
    Inflammatory Inflammatory Lesions (as
    Lesions Percent of Baseline)
    Baseline (mean) 77.4 100
    Day 28 (mean) 52.1 66
    Day 56 (mean) 44.3 56
    Day 84 (mean) 41.9 53
  • While effective as a treatment for acne, this resulted in almost no side effects above those observed with a placebo, as shown in Table 2.
    TABLE 2
    % Subjects with Adverse Events
    Minocycline Placebo
    At least One Adverse Event 56.2 54.1
    At Least One Serious 0.4 0
    Adverse Event
    Blood/Lymphatic System 0.3 0.3
    Disorders
    Cardiac Disorders 0.3 0
    Ear and Labyrinth Disorders 3.6 3.3
    Endocrine Disorders 0.3 0
    Eye Disorders 2.2 2.7
    Gastrointestinal Disorders 21.2 26.1
    General Disorders and 13.8 10.4
    Administrative Site
    Conditions
    Immune System Disorders 0.7 2.5
    Infections and Infestations 9.3 11.0
    Laboratory Blood 0.7 1.1
    Abnormalities
    Metabolism and Nutrition 0.6 0.3
    Disorders
    Musculoskeletal and 4.6 3.6
    Connective Disorders
    Neoplasms Benign, 0.1 0
    Malignant and Unspecified
    Nervous System Disorders 29.2 25.8
    Psychiatric Disorders 6.4 7.1
    Renal and Urinary Disorders 0.3 0.5
    Reproductive System and 0.7 0.3
    Breast Disorders
    Respiratory, Thoracic and 5.3 6.9
    Mediastinal Disorders
    Skin and Subcutaneous 8.6 7.1
    Tissue Disorders
    Vascular Disorders 1.0 0.3
  • The effectiveness of this invention can be seen by comparing the above efficacy data with published data on the effectiveness of conventional tetracycline treatments for acne in the reduction of total acne lesions and in the reduction of inflammatory lesions. See, e.g. Hersel & Gisslen, “Minocycline in Acne Vulgaris: A Double Blind Study,” Current Therapeutic Research, 1976.
  • Because of the variations in body weight encountered in clinical practice, in the actual practice of this invention it is not practical to provide every patient with exactly 1 mg/kg/day of oral tetracycline antibiotic. However, it is acceptable to approximate this dose by providing the patient with from 0.5 to 1.5 mg/kg/day although from 0.7 to 1.3 mg/kg/day is preferred, and 1.0 mg/kg/day is ideal.
  • While it can be effective to provide the oral tetracycline antibiotic in divided doses taken over the course of a day (e.g. twice or three times a day), it is preferable to provide the oral tetracycline antibiotic in a dosage form that releases the antibiotic slowly during the course of a day so that once-a-day dosing is possible. While delayed release dosage forms are known in the art, the formulation of them is far from predictable and the selection of a specific delayed release formulation is accomplished more by trial and error than by mathematical prediction based on known properties of delay release agents. No delayed release product useful in the present invention has been known heretofore.
  • It has been discovered that the ratio of fast dissolving carriers to slow dissolving carriers in the core caplet is important in obtaining a dissolution profile that enables once-a-day dosing in accordance with the present invention. By keeping the ratio of these components within a certain range, one may obtain this result.
  • The fast dissolving carrier is any binder, vehicle, or excipient that quickly dissolves in an aqueous physiological medium, such as gastric fluid, thereby tending to quickly release the active ingredient. Lactose, its salts and hydrates are good examples of such components. It has been observed that sometimes a portion of the fast dissolving components are formulated in a manner that results in the complete or partial encapsulation or inclusion or coating of these fast-dissolving materials in granules of slow-dissolving materials. These encapsulated materials are excluded from the calculation of the above mentioned ratio of fast-dissolving to slow dissolving components.
  • A slow dissolving carrier is any binder, vehicle, or excipient that dissolves slowly over the course of hours and perhaps a day, thereby slowing the release of the active ingredient. Examples of such components are polyvinyl pyrrolidone, polyvinyl acetate, microcrystalline cellulose, methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, or waxy or lipid-based tableting agents such as magnesium stearate or calcium stearate. Outer “enteric” coatings are excluded from this amount when calculating the above-mentioned ratio.
  • Insoluble carriers are binders, vehicles, or excipients that are practically insoluble in physiological fluids, such as gastric fluid, and includes compounds, such as silicon dioxide and talc.
  • While the exact formulation of these dosage forms can vary, it has been observed that it is advantageous to formulate them so that the ratio of fast dissolving carriers to slow dissolving carriers is from 0.30 to 0.50, and preferably from 0.35 to 0.45. A ratio of about 0.36 to 0.40 is particularly preferable.
  • Dosage forms, such as capsules, tablets, and caplets that release 25 to 52% of the antibiotics within 1 hour, 53 to 89% in 2 hours, and at least 90% within 4 hours are suited to the once-a-day dosage regimen contemplated by the current inventories. More preferably, 30 to 52% of the antibiotic is released within 1 hour, 53 to 84% within 2 hours, and at least 85% within 4 hours.
  • Alternatively, the oral tetracycline antibiotic may be delivered in a dosage form that releases the antibiotic in such a way that the maximum blood concentration of the antibiotic (Cmax) is reached at about 3.5 hours after administration (Tmax). In actual practice of the invention, the Cmax should be reached between 2.75 and 4.0 after administration, more preferably between 3.0 and 3.75 after administration.
  • As examples of such a once-a-day formulation, one may use the following:
    Component Quantity (mg)
    135 mg Caplet
    Minocycline (as hydrochloride) 145.8
    (dry weight)
    Lactose Monohydrate (intragranular) 107.4
    Lactose Monohydrate (extragranular) 43.8
    Total Lactose Monohydrate 151.2
    HPMC 94
    Silicon Dioxide 3
    Mg. Stearate 6
    45 mg Caplet
    Minocycline (as hydrochloride) 48.6
    (dry weight)
    Lactose Monohydrate (intragranular) 192.2
    Lactose Monohydrate (extragranular) 42.2
    Total Lactose Monohydrate 234.40
    HPMC 108
    Silicon Dioxide 3
    Mg. Stearate 6
  • Each of these components is combined in a conventional fashion, compressed in a tabletting apparatus, and then provided in a conventional manner with a suitable coating, such as, without limitation Opadry II and optional coloring.

Claims (15)

  1. 1-5. (canceled)
  2. 6. An oral dosage form, comprising:
    an antibiotically effective dose of an oral minocycline; and
    a pharmaceutically suitable delivery vehicle;
    wherein said oral dosage form is for administration once daily to provide a patient with about 0.5 mg/kg/day to about 1.5 mg/kg/day of said oral minocycline; and
    wherein said oral dosage form provides a continuous slow release, without a loading dose, of said oral minocycline, at a release rate in gastric fluid of either about 25% to about 52% within about 1 hour, about 53% to about 89% within about 2 hours, and at least about 90% within about 4 hours, or about 30% to about 52% within about 1 hour, about 53% to about 84% within about 2 hours, and at least about 85% within about 4 hours.
  3. 7. The oral dosage form of claim 6, wherein said oral minocycline is minocycline as hydrochloride.
  4. 8. The oral dosage form of claim 6, wherein said oral dosage form is for administration once daily to provide said patient with about 1.0 mg/kg/day of said oral minocycline.
  5. 9. An oral dosage form, comprising:
    an antibiotically effective dose of an oral minocycline; and
    a pharmaceutically suitable delivery vehicle;
    wherein said oral dosage form is for administration once daily to provide a patient with about 0.5 mg/kg/day to about 1.5 mg/kg/day of said oral minocycline; and
    wherein said oral dosage form does not provide an immediate release of said oral minocycline, and provides a continuous slow release, without a loading dose, of said oral minocycline at a rate so that Cmax is reached at about 3.5 hours after administration to said patient.
  6. 10. The oral dosage form of claim 9, wherein said oral minocycline is minocycline as hydrochloride.
  7. 11. The oral dosage form of claim 9, wherein said oral dosage form is for administration once daily to provide said patient with about 1.0 mg/kg/day of said oral minocycline.
  8. 12. An oral dosage form, comprising:
    an antibiotically effective dose of an oral minocycline;
    a fast dissolving carrier; and
    a slow dissolving carrier, wherein said fast dissolving carrier and said slow dissolving carrier are at a weight ratio of about 0.3 to about 0.5 that provides a continuous, slow release, without immediate release, of said oral minocycline; and
    wherein said oral dosage form is for administration once daily to provide a patient with about 0.5 mg/kg/day to about 1.5 mg/kg/day of said oral minocycline.
  9. 13. The oral dosage form of claim 12, wherein said oral minocycline is minocycline as hydrochloride.
  10. 14. The oral dosage form of claim 12, wherein said weight ratio of fast dissolving carrier to slow dissolving carrier is 0.35 to 0.45.
  11. 15. The oral dosage form of claim 14, wherein said weight ratio of fast dissolving carrier to slow dissolving carrier is 0.36 to 0.40.
  12. 16. The oral dosage form of claim 12, wherein said oral dosage form is for administration once daily to provide said patient with about 1.0 mg/kg/day of said oral minocycline.
  13. 17. The oral dosage form of claim 12, further comprising an intragranular fast dissolving carrier.
  14. 18. The oral dosage form of claim 17, wherein said slow dissolving carrier encapsulates said intragranular fast dissolving carrier.
  15. 19. The oral dosage form of claim 18, further comprising a coating.
US11944186 2005-06-24 2007-11-21 Method for the treatment of acne Abandoned US20080182827A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11166817 US7919483B2 (en) 2005-06-24 2005-06-24 Method for the treatment of acne
US11944186 US20080182827A2 (en) 2005-06-24 2007-11-21 Method for the treatment of acne

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11944186 US20080182827A2 (en) 2005-06-24 2007-11-21 Method for the treatment of acne

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11166817 Division US7919483B2 (en) 2005-06-24 2005-06-24 Method for the treatment of acne

Publications (2)

Publication Number Publication Date
US20080070872A1 true US20080070872A1 (en) 2008-03-20
US20080182827A2 true true US20080182827A2 (en) 2008-07-31

Family

ID=37568356

Family Applications (6)

Application Number Title Priority Date Filing Date
US11166817 Active 2027-03-07 US7919483B2 (en) 2005-06-24 2005-06-24 Method for the treatment of acne
US11776669 Abandoned US20080182825A2 (en) 2005-06-24 2007-07-12 Method for the treatment of acne
US11776676 Abandoned US20080182826A2 (en) 2005-06-24 2007-07-12 Method for the treatment of acne
US11776691 Abandoned US20070275933A1 (en) 2005-06-24 2007-07-12 Method for the treatment of acne
US11776711 Abandoned US20080181945A2 (en) 2005-06-24 2007-07-12 Method for the treatment of acne
US11944186 Abandoned US20080182827A2 (en) 2005-06-24 2007-11-21 Method for the treatment of acne

Family Applications Before (5)

Application Number Title Priority Date Filing Date
US11166817 Active 2027-03-07 US7919483B2 (en) 2005-06-24 2005-06-24 Method for the treatment of acne
US11776669 Abandoned US20080182825A2 (en) 2005-06-24 2007-07-12 Method for the treatment of acne
US11776676 Abandoned US20080182826A2 (en) 2005-06-24 2007-07-12 Method for the treatment of acne
US11776691 Abandoned US20070275933A1 (en) 2005-06-24 2007-07-12 Method for the treatment of acne
US11776711 Abandoned US20080181945A2 (en) 2005-06-24 2007-07-12 Method for the treatment of acne

Country Status (6)

Country Link
US (6) US7919483B2 (en)
EP (1) EP1898925A4 (en)
JP (2) JP2008543936A (en)
CN (1) CN101208097A (en)
CA (1) CA2613273C (en)
WO (1) WO2007001961A3 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110092677A1 (en) * 2001-08-30 2011-04-21 Biorexis Technology, Inc. Modified transferin-antibody fusion proteins
CA2533150C (en) * 2003-07-25 2013-03-12 Warner Chilcott Company, Inc. A doxycycline metal complex in a solid dosage form
CA2595481C (en) * 2005-01-21 2014-05-13 Warner Chilcott Company, Inc. A tetracycline metal complex in a solid dosage form
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
KR20090122994A (en) * 2007-03-23 2009-12-01 몰레큘러 리서치 센터, 인크. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en) * 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
WO2008121107A1 (en) * 2007-04-02 2008-10-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
US20120027855A1 (en) * 2007-07-06 2012-02-02 Lupin Limited Pharmaceutical compositions for gastrointestinal drug delivery
US20100215744A1 (en) * 2008-08-06 2010-08-26 Medicis Pharmaceutical Corporation Hydroxypropyl Substitution Used to Regulate Dissolution of a Chemical
WO2010017310A1 (en) * 2008-08-06 2010-02-11 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
WO2012153884A1 (en) * 2011-05-12 2012-11-15 (주)아모레퍼시픽 Composition having improved stability for ameliorating acne
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
JP2018509472A (en) 2015-03-23 2018-04-05 バイオファーミクス・インコーポレイテッドBioPharmX, Inc. Dermopharmaceutical composition tetracycline
WO2016162754A1 (en) 2015-04-07 2016-10-13 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions for minocycline

Citations (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932615A (en) * 1973-03-16 1976-01-13 Meiji Seika Co., Ltd. Process for the preparation of granules
US3957980A (en) * 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
US3966922A (en) * 1971-07-23 1976-06-29 Takeda Chemical Industries, Ltd. Composition for poultry and livestock
US4086332A (en) * 1976-01-02 1978-04-25 Pfizer Inc. Doxycycline compositions
US4126680A (en) * 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
US4376118A (en) * 1980-10-06 1983-03-08 Miles Laboratories, Inc. Stable nonaqueous solution of tetracycline salt
US4376172A (en) * 1982-02-01 1983-03-08 Cincinnati Milacron Inc. Closed loop control of compressible fluid addition to a mixture of such fluid and a liquid
US4443442A (en) * 1979-12-21 1984-04-17 Skillern Scott D Method and composition for treatment of acne vulgaris
US4701320A (en) * 1984-11-29 1987-10-20 Lederle (Japan), Ltd. Composition stably containing minocycline for treating periodontal diseases
US4764377A (en) * 1983-10-07 1988-08-16 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
US4792448A (en) * 1987-06-11 1988-12-20 Pfizer Inc. Generic zero order controlled drug delivery system
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds
US4925833A (en) * 1983-12-29 1990-05-15 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
US4935412A (en) * 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4960913A (en) * 1987-09-18 1990-10-02 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. Process for the preparation of pharmaceutical compositions
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5122519A (en) * 1989-06-27 1992-06-16 American Cyanamid Company Stable, cosmetically acceptable topical gel formulation and method of treatment for acne
US5167964A (en) * 1992-02-14 1992-12-01 Warner-Lambert Company Semi-enteric drug delivery systems and methods for preparing same
US5188836A (en) * 1990-07-27 1993-02-23 Warner-Lambert Company Sustained release formulations
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5209978A (en) * 1985-12-26 1993-05-11 Taisho Pharmaceutical Co., Ltd. Seamless soft capsule and production thereof
US5211958A (en) * 1987-11-30 1993-05-18 Gist-Brocades, N.V. Pharmaceutical composition and process for its preparation
US5217493A (en) * 1992-03-11 1993-06-08 Board Of Regents, The University Of Texas System Antibacterial coated medical implants
US5230895A (en) * 1990-05-01 1993-07-27 Copley Pharmaceutical Inc. Sustained released delivery system for use in the periodontal pocket
US5262173A (en) * 1992-03-02 1993-11-16 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
US5277916A (en) * 1988-02-01 1994-01-11 F. H. Faulding & Co., Ltd. Tetracycline dosage form
US5283065A (en) * 1989-09-21 1994-02-01 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5300304A (en) * 1989-09-21 1994-04-05 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
US5324751A (en) * 1989-01-24 1994-06-28 Ici Americas Inc. Cryoprotectant sorbitol crystal spherules
US5459135A (en) * 1989-12-04 1995-10-17 The Research Foundation Of State University Of New York Composition comprising indomethacin [non-steroidal anti-inflammatory agent] and effectively non-antibacterial tetracycline to reduce bone loss
US5518730A (en) * 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5554654A (en) * 1986-12-23 1996-09-10 Tristrata Inc Method for enhancing the therapeutic effect of an anti-acne agent
US5582837A (en) * 1992-03-25 1996-12-10 Depomed, Inc. Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
US5665776A (en) * 1986-12-23 1997-09-09 Tristrata Technology, Inc. Additives enhancing topical actions of therapeutic agents
US5674539A (en) * 1994-12-09 1997-10-07 Tomas; Robert E. Method of treating skin and composition
US5776489A (en) * 1989-09-21 1998-07-07 American Cyanamid Company Controlled release carbonic anhydrase inhibitor containing pharmaceutical compositions from spherical granules in capsule oral dosage unit form
US5780049A (en) * 1991-10-16 1998-07-14 Richardson-Vicks Inc. Enhanced skin penetration system for improved topical delivery of drugs
US5800836A (en) * 1992-08-05 1998-09-01 F. H. Faulding & Co. Limited Pelletized pharmaceutical composition
US5814331A (en) * 1995-11-13 1998-09-29 Holen; Sheldon Process for inhibiting pathogenic bacteria in the oral cavity and for binding peptide growth factors on surfaces
US5834450A (en) * 1994-02-17 1998-11-10 Pfizer Inc. 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5855904A (en) * 1994-11-01 1999-01-05 Dong Kook Pharmaceutical Co., Ltd. Biodegradable sustained release preparation for treating periodontitis
US5908838A (en) * 1998-02-19 1999-06-01 Medics Pharmaceutical Corporation Method for the treatment of acne
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
US6087382A (en) * 1999-03-17 2000-07-11 Bonner, Jr.; Ernest L. Method for treatment of reactive arthritis or bursitis
US6120803A (en) * 1997-08-11 2000-09-19 Alza Corporation Prolonged release active agent dosage form adapted for gastric retention
US6165513A (en) * 1997-06-11 2000-12-26 The Procter & Gamble Co. Film-coated tablet for improved upper gastrointestinal tract safety
US6165999A (en) * 1995-05-03 2000-12-26 Pfizer Inc Tetracycline derivatives
US6194000B1 (en) * 1995-10-19 2001-02-27 F.H. Faulding & Co., Limited Analgesic immediate and controlled release pharmaceutical composition
US6340475B2 (en) * 1997-06-06 2002-01-22 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
US6340476B1 (en) * 1999-04-06 2002-01-22 Armaquest, Inc. Pharmaceutical dosage form for pulsatile delivery of methylphenidate
US20020015731A1 (en) * 1999-12-23 2002-02-07 Appel Leah E. Hydrogel-Driven Drug Dosage Form
US6429204B1 (en) * 1997-01-15 2002-08-06 University Of Miami Method of inhibiting cancer growth
US6455583B1 (en) * 1998-05-08 2002-09-24 The University Of Miami Method for treating meibomian gland disease
US6497902B1 (en) * 1999-12-01 2002-12-24 The Regents Of The University Of Michigan Ionically crosslinked hydrogels with adjustable gelation time
US20030082120A1 (en) * 2001-10-26 2003-05-01 Milstein Harold J. Method for reducing systemic effects of aging, effects of aging on the skin, and incidence of skin damage from sun exposure using antibiotics of the tetracycline family
US20030130240A1 (en) * 2001-04-05 2003-07-10 Ashley Robert A. Methods of treating acne
US20030199480A1 (en) * 2002-04-12 2003-10-23 David Hayes Modified release preparation
US6638922B2 (en) * 1998-11-18 2003-10-28 Collagenex Pharmaceuticals Incorporated 4-dedimethylaminotetracycline derivatives
US20030229055A1 (en) * 2002-04-16 2003-12-11 Ashley Robert A. Methods of simultaneously treating ocular rosacea and acne rosacea
US6673843B2 (en) * 1999-06-30 2004-01-06 Emory University Curcumin and curcuminoid inhibition of angiogenesis
US20040115261A1 (en) * 2001-04-05 2004-06-17 Ashley Robert A. Controlled delivery of tetracycline compounds and tetracycline derivatives
US20040127471A1 (en) * 2002-09-17 2004-07-01 Barry Reisberg Methods of treating age associated memory impairment (AAMI), mild cognitive impairment (MCI), and dementias with cell cycle inhibitors
US20040228912A1 (en) * 2003-04-07 2004-11-18 Rong-Kun Chang Once daily formulations of tetracyclines
US6863830B1 (en) * 2003-08-21 2005-03-08 Biolab Services, Inc. Dual layer tablet, method of making and use thereof
US20050136107A1 (en) * 2003-12-22 2005-06-23 Patel Mahendra R. Extended release antibiotic composition
US20050148552A1 (en) * 2003-11-06 2005-07-07 Ryan Maria E. Methods of treating eczema
US20060293290A1 (en) * 2005-06-24 2006-12-28 Medicis Pharmaceutical Corporation Method for the treatment of acne

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05502465A (en) * 1989-08-28 1993-04-28
FI922107A0 (en) 1991-05-10 1992-05-08 Faulding F H & Co Ltd Mikrokapselkomposition Science foerfarande.
ES2124303T3 (en) 1992-03-25 1999-02-01 Depomed Inc Dosage forms of oral drugs based delayed release hydroxyethylcellulose.
US5783212A (en) * 1996-02-02 1998-07-21 Temple University--of the Commonwealth System of Higher Education Controlled release drug delivery system
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
US8828432B2 (en) * 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
KR100296413B1 (en) * 1998-04-01 2001-05-10 김선진 Sustained released tablet containing cefaclor
US6015804A (en) * 1998-09-11 2000-01-18 The Research Foundation Of State University Of New York Method of using tetracycline compounds to enhance interleukin-10 production
DK1169024T3 (en) * 1999-03-31 2006-05-08 Janssen Pharmaceutica Nv Pregelatinized starch in a controlled release formulation
JP3888064B2 (en) * 2000-01-27 2007-02-28 田辺製薬株式会社 Sustained release formulations and their preparation
WO2002080932A1 (en) 2001-04-05 2002-10-17 Collagenex Pharmaceuticals, Inc. Methods of treating acne
US6585997B2 (en) * 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
CA2409552A1 (en) * 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
US7985422B2 (en) 2002-08-05 2011-07-26 Torrent Pharmaceuticals Limited Dosage form
JP4443834B2 (en) * 2003-01-24 2010-03-31 日清ファルマ株式会社 Release tablets and a method for manufacturing the same
WO2004078111A3 (en) 2003-03-06 2004-10-28 Prashant Manohar Mandaogade Extended release minocycline compositions and processes for their preparation
GB2414668B (en) 2004-06-03 2009-07-29 Dexcel Ltd Tetracycline modified release delivery system
US20080242642A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en) * 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne

Patent Citations (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966922A (en) * 1971-07-23 1976-06-29 Takeda Chemical Industries, Ltd. Composition for poultry and livestock
US3957980A (en) * 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
US3932615A (en) * 1973-03-16 1976-01-13 Meiji Seika Co., Ltd. Process for the preparation of granules
US4086332A (en) * 1976-01-02 1978-04-25 Pfizer Inc. Doxycycline compositions
US4126680A (en) * 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US4443442A (en) * 1979-12-21 1984-04-17 Skillern Scott D Method and composition for treatment of acne vulgaris
US4376118A (en) * 1980-10-06 1983-03-08 Miles Laboratories, Inc. Stable nonaqueous solution of tetracycline salt
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
US4376172A (en) * 1982-02-01 1983-03-08 Cincinnati Milacron Inc. Closed loop control of compressible fluid addition to a mixture of such fluid and a liquid
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US4764377A (en) * 1983-10-07 1988-08-16 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
US4935411A (en) * 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4925833A (en) * 1983-12-29 1990-05-15 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
US4935412A (en) * 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4701320A (en) * 1984-11-29 1987-10-20 Lederle (Japan), Ltd. Composition stably containing minocycline for treating periodontal diseases
US5209978A (en) * 1985-12-26 1993-05-11 Taisho Pharmaceutical Co., Ltd. Seamless soft capsule and production thereof
US5665776A (en) * 1986-12-23 1997-09-09 Tristrata Technology, Inc. Additives enhancing topical actions of therapeutic agents
US5554654A (en) * 1986-12-23 1996-09-10 Tristrata Inc Method for enhancing the therapeutic effect of an anti-acne agent
US4792448A (en) * 1987-06-11 1988-12-20 Pfizer Inc. Generic zero order controlled drug delivery system
US4960913A (en) * 1987-09-18 1990-10-02 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. Process for the preparation of pharmaceutical compositions
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds
US5211958A (en) * 1987-11-30 1993-05-18 Gist-Brocades, N.V. Pharmaceutical composition and process for its preparation
US5277916A (en) * 1988-02-01 1994-01-11 F. H. Faulding & Co., Ltd. Tetracycline dosage form
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5324751A (en) * 1989-01-24 1994-06-28 Ici Americas Inc. Cryoprotectant sorbitol crystal spherules
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5122519A (en) * 1989-06-27 1992-06-16 American Cyanamid Company Stable, cosmetically acceptable topical gel formulation and method of treatment for acne
US5300304A (en) * 1989-09-21 1994-04-05 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
US5413777A (en) * 1989-09-21 1995-05-09 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
US5283065A (en) * 1989-09-21 1994-02-01 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5776489A (en) * 1989-09-21 1998-07-07 American Cyanamid Company Controlled release carbonic anhydrase inhibitor containing pharmaceutical compositions from spherical granules in capsule oral dosage unit form
US5459135A (en) * 1989-12-04 1995-10-17 The Research Foundation Of State University Of New York Composition comprising indomethacin [non-steroidal anti-inflammatory agent] and effectively non-antibacterial tetracycline to reduce bone loss
US5230895A (en) * 1990-05-01 1993-07-27 Copley Pharmaceutical Inc. Sustained released delivery system for use in the periodontal pocket
US5188836A (en) * 1990-07-27 1993-02-23 Warner-Lambert Company Sustained release formulations
US5780049A (en) * 1991-10-16 1998-07-14 Richardson-Vicks Inc. Enhanced skin penetration system for improved topical delivery of drugs
US5167964A (en) * 1992-02-14 1992-12-01 Warner-Lambert Company Semi-enteric drug delivery systems and methods for preparing same
US5262173A (en) * 1992-03-02 1993-11-16 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
US5348748A (en) * 1992-03-02 1994-09-20 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
US5217493A (en) * 1992-03-11 1993-06-08 Board Of Regents, The University Of Texas System Antibacterial coated medical implants
US5582837A (en) * 1992-03-25 1996-12-10 Depomed, Inc. Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
US5518730A (en) * 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5800836A (en) * 1992-08-05 1998-09-01 F. H. Faulding & Co. Limited Pelletized pharmaceutical composition
US5834450A (en) * 1994-02-17 1998-11-10 Pfizer Inc. 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5855904A (en) * 1994-11-01 1999-01-05 Dong Kook Pharmaceutical Co., Ltd. Biodegradable sustained release preparation for treating periodontitis
US5674539A (en) * 1994-12-09 1997-10-07 Tomas; Robert E. Method of treating skin and composition
US6165999A (en) * 1995-05-03 2000-12-26 Pfizer Inc Tetracycline derivatives
US6194000B1 (en) * 1995-10-19 2001-02-27 F.H. Faulding & Co., Limited Analgesic immediate and controlled release pharmaceutical composition
US5814331A (en) * 1995-11-13 1998-09-29 Holen; Sheldon Process for inhibiting pathogenic bacteria in the oral cavity and for binding peptide growth factors on surfaces
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
US6429204B1 (en) * 1997-01-15 2002-08-06 University Of Miami Method of inhibiting cancer growth
US6340475B2 (en) * 1997-06-06 2002-01-22 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
US6165513A (en) * 1997-06-11 2000-12-26 The Procter & Gamble Co. Film-coated tablet for improved upper gastrointestinal tract safety
US6120803A (en) * 1997-08-11 2000-09-19 Alza Corporation Prolonged release active agent dosage form adapted for gastric retention
US5908838A (en) * 1998-02-19 1999-06-01 Medics Pharmaceutical Corporation Method for the treatment of acne
US6455583B1 (en) * 1998-05-08 2002-09-24 The University Of Miami Method for treating meibomian gland disease
US6638922B2 (en) * 1998-11-18 2003-10-28 Collagenex Pharmaceuticals Incorporated 4-dedimethylaminotetracycline derivatives
US20040002481A1 (en) * 1998-11-18 2004-01-01 Collagenex Pharmaceuticals, Inc. Novel 4-dedimethylaminotetracycline derivatives
US6087382A (en) * 1999-03-17 2000-07-11 Bonner, Jr.; Ernest L. Method for treatment of reactive arthritis or bursitis
US6340476B1 (en) * 1999-04-06 2002-01-22 Armaquest, Inc. Pharmaceutical dosage form for pulsatile delivery of methylphenidate
US6673843B2 (en) * 1999-06-30 2004-01-06 Emory University Curcumin and curcuminoid inhibition of angiogenesis
US6497902B1 (en) * 1999-12-01 2002-12-24 The Regents Of The University Of Michigan Ionically crosslinked hydrogels with adjustable gelation time
US20020015731A1 (en) * 1999-12-23 2002-02-07 Appel Leah E. Hydrogel-Driven Drug Dosage Form
US20030139380A1 (en) * 2001-04-05 2003-07-24 Ashley Robert A. Use methods of treating acne and telangiectasia
US7211267B2 (en) * 2001-04-05 2007-05-01 Collagenex Pharmaceuticals, Inc. Methods of treating acne
US20030130240A1 (en) * 2001-04-05 2003-07-10 Ashley Robert A. Methods of treating acne
US20040115261A1 (en) * 2001-04-05 2004-06-17 Ashley Robert A. Controlled delivery of tetracycline compounds and tetracycline derivatives
US20030082120A1 (en) * 2001-10-26 2003-05-01 Milstein Harold J. Method for reducing systemic effects of aging, effects of aging on the skin, and incidence of skin damage from sun exposure using antibiotics of the tetracycline family
US6958161B2 (en) * 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
US20030199480A1 (en) * 2002-04-12 2003-10-23 David Hayes Modified release preparation
US7008631B2 (en) * 2002-04-16 2006-03-07 Collagenex Pharmaceuticals, Inc. Methods of simultaneously treating ocular rosacea and acne rosacea
US20030229055A1 (en) * 2002-04-16 2003-12-11 Ashley Robert A. Methods of simultaneously treating ocular rosacea and acne rosacea
US20040127471A1 (en) * 2002-09-17 2004-07-01 Barry Reisberg Methods of treating age associated memory impairment (AAMI), mild cognitive impairment (MCI), and dementias with cell cycle inhibitors
US20040228912A1 (en) * 2003-04-07 2004-11-18 Rong-Kun Chang Once daily formulations of tetracyclines
US6863830B1 (en) * 2003-08-21 2005-03-08 Biolab Services, Inc. Dual layer tablet, method of making and use thereof
US20050148552A1 (en) * 2003-11-06 2005-07-07 Ryan Maria E. Methods of treating eczema
US20050136107A1 (en) * 2003-12-22 2005-06-23 Patel Mahendra R. Extended release antibiotic composition
US20060293290A1 (en) * 2005-06-24 2006-12-28 Medicis Pharmaceutical Corporation Method for the treatment of acne
US20070254855A1 (en) * 2005-06-24 2007-11-01 Medicis Pharmaceutical Corporation Method for the treatment of acne
US20070259039A1 (en) * 2005-06-24 2007-11-08 Medicis Pharmaceutical Corporation Method for the treatment of acne
US20070270390A1 (en) * 2005-06-24 2007-11-22 Medicis Pharmaceutical Corporation Method of the treament of acne
US20070275933A1 (en) * 2005-06-24 2007-11-29 Medicis Pharmaceutical Corporation Method for the treatment of acne

Also Published As

Publication number Publication date Type
US20070275933A1 (en) 2007-11-29 application
EP1898925A4 (en) 2009-07-29 application
US20080182826A2 (en) 2008-07-31 application
US20070259039A1 (en) 2007-11-08 application
US20080182825A2 (en) 2008-07-31 application
CN101208097A (en) 2008-06-25 application
JP2008543936A (en) 2008-12-04 application
CA2613273A1 (en) 2007-01-04 application
CA2613273C (en) 2015-12-08 grant
US7919483B2 (en) 2011-04-05 grant
US20070254855A1 (en) 2007-11-01 application
US20080070872A1 (en) 2008-03-20 application
US20060293290A1 (en) 2006-12-28 application
JP2013213047A (en) 2013-10-17 application
US20070225262A2 (en) 2007-09-27 application
JP5744976B2 (en) 2015-07-08 grant
US20080181945A2 (en) 2008-07-31 application
EP1898925A2 (en) 2008-03-19 application
US20070270390A1 (en) 2007-11-22 application
WO2007001961A3 (en) 2007-05-18 application
WO2007001961A2 (en) 2007-01-04 application

Similar Documents

Publication Publication Date Title
US6551616B1 (en) Extended release formulations of erythromycin derivatives
US6479496B1 (en) Methods for treating angina with ranolazine
US20050232986A1 (en) Dosage form containing promethazine and another drug
US6303607B1 (en) Method for administering a sustained release ranolanolazine formulation
US20040121004A1 (en) Dosage forms containing a PPI, NSAID, and buffer
US20040131676A1 (en) Dosage forms containing a PPI, NSAID, and buffer
US20030190355A1 (en) Modified release minerals
US20060057205A1 (en) Phenylepherine containing dosage form
US20030152628A1 (en) Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in an immediate-release layer with levodopa ethyl ester in a controlled release core
US20070243251A1 (en) Dosage Forms Containing A PPI, NSAID, and Buffer
US20060134207A1 (en) Dosage form containing diphenhydramine and another drug
US20050232987A1 (en) Dosage form containing a morphine derivative and another drug
US20070003622A1 (en) Diphenhydramine containing dosage form
US20040115265A1 (en) Multilayered tablet containing pravastatin and aspirin and method
US20060029664A1 (en) Dosage form containing carbetapentane and another drug
US20050281875A1 (en) Promethazine containing dosage form
US20040048902A1 (en) Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient
US20030147957A1 (en) Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in immediate release layer with levodopa ethyl ester and a decarboxylase inhibitor in a controlled release core
WO2010057036A2 (en) Solid composition for controlled release of ionizable active agents with poor aqueous solubility at low ph and methods of use thereof
Bayley et al. Nifedipine in the treatment of hypertension: report of a double‐blind controlled trial.
US20060263427A1 (en) Quinine formulations
WO2009034541A2 (en) Controlled release pharmaceutical dosage forms of trimetazidine
US20040186180A1 (en) Non-steroidal anti-inflammatory drug dosing regimen
US20040029843A1 (en) Rapidly disintegrating formulations for treating or preventing mucositis
US20060293290A1 (en) Method for the treatment of acne