US20080172044A1 - Drug Delivery Apparatus and Method for Automatically Reducing Drug Dosage - Google Patents

Drug Delivery Apparatus and Method for Automatically Reducing Drug Dosage Download PDF

Info

Publication number
US20080172044A1
US20080172044A1 US11/929,401 US92940107A US2008172044A1 US 20080172044 A1 US20080172044 A1 US 20080172044A1 US 92940107 A US92940107 A US 92940107A US 2008172044 A1 US2008172044 A1 US 2008172044A1
Authority
US
United States
Prior art keywords
drug delivery
delivery
reduction
delivery device
method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/929,401
Inventor
Brian M. Shelton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Infusion Systems LLC
Original Assignee
Infusion Systems LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US60499904P priority Critical
Priority to US11/182,307 priority patent/US20060047270A1/en
Application filed by Infusion Systems LLC filed Critical Infusion Systems LLC
Priority to US11/929,401 priority patent/US20080172044A1/en
Assigned to INFUSION SYSTEMS, LLC reassignment INFUSION SYSTEMS, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
Assigned to BOSTON SCIENTIFIC NEUROMODULATION CORPORATION reassignment BOSTON SCIENTIFIC NEUROMODULATION CORPORATION CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: ADVANCED BIONICS CORPORATION
Publication of US20080172044A1 publication Critical patent/US20080172044A1/en
Application status is Abandoned legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M2005/14208Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/35Communication
    • A61M2205/3507Communication with implanted devices, e.g. external control
    • A61M2205/3523Communication with implanted devices, e.g. external control using telemetric means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/35Communication
    • A61M2205/3546Range
    • A61M2205/3561Range local, e.g. within room or hospital
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804Flow controllers
    • A61M5/16827Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths

Abstract

A drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump mechanism or valve, and a drug delivery control means. The drug delivery control means comprises a controller, e.g., a microprocessor or microcontroller which is operable to automatically reduce the rate of drug delivery over a certain reduction interval (e.g., multiple days) from an initial dosage value to a final dosage value.

Description

    RELATED APPLICATIONS
  • This application is a CIP of U.S. application Ser. No. 11/069,573 filed on 28 Feb. 2005 which is incorporated herein by reference. This application claims the benefit of U.S. Provisional Application 60/604,999 filed on 27 Aug. 2004 which is incorporated herein by reference.
  • FIELD OF THE INVENTION
  • This invention relates generally to medical devices for delivering a medication, or drug, to a body site at flow rates and times specified by a stored drug delivery profile. More particularly, this invention relates to such devices which can operate to automatically gradually modify rates of drug delivery to achieve a desired target dosage.
  • BACKGROUND OF THE INVENTION
  • Various implantable drug delivery devices are known in the art which can be programmed to deliver a drug to a body site for infusion at flow rates and times dictated by a stored drug delivery profile. Such delivery devices typically include a refillable reservoir for storing a fluid drug and a controllable fluid transfer device (e.g., a pump or valve) for transferring fluid from the reservoir to a catheter for delivery to the body site. The drug delivery profile comprises a data set specifying a schedule of flow rates for a periodic cycle, or period, of a certain duration. For example, the duration of a period can be twelve hours, twenty four hours, or one week, etc. The particular profile used to control drug delivery is typically specified by the patient's clinician and depends upon several factors including the particular drug formulation being delivered, the patient's condition, the therapy being administered, etc.
  • The delivery profile is typically stored in the medical device at the time of implanting and can thereafter be modified by a clinician (using an external controller or programmer) when the patient periodically visits for a refill/checkup, e.g., once per month.
  • In the course of certain drug therapies, it may be desirable to increase or reduce the drug dosage delivered to the patient. For example, in some situations, it may be helpful to reduce or terminate drug administration for a limited period in order to increase the patient's sensitivity to the drug. In still other situations, it may be desirable to terminate delivery of a drug as an initial step in preparation for changing the drug formulation.
  • For illustrative purposes, in situations where a therapeutic decision has been made to reduce or eliminate delivery of a certain drug, it is generally desirable to reduce the drug dosage gradually. This gradual reduction, which is sometimes referred to as a detoxification procedure, is relatively easy to administer if the patient is available to the clinician on a frequent basis, e.g., daily. However, in the use of implanted drug delivery devices, patients typically visit their clinicians infrequently, e.g., once per month, and it has therefore been inconvenient and impractical to administer a drug modification program. The present invention is directed to an implantable drug delivery apparatus and method of operation which facilitates the automatic gradual modification, e.g., reduction of drug delivery over an extended interval, e.g., many days.
  • SUMMARY OF THE INVENTION
  • The present invention relates to a drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump or valve mechanism, and a drug delivery controller. The controller, e.g., a microprocessor, is operable in accordance with the invention, to automatically gradually reduce the rate of drug delivery specified by a stored delivery profile from a current dosage value to a targeted final dosage value.
  • In accordance with a preferred embodiment, dosage reduction is achieved over an interval comprised of multiple periods, where a period may, for example, comprise 4, 12, or 24 hours. An initial delivery profile specifies an initial delivery rate (or rates). Delivery rates for each subsequent period within the reduction interval are determined by applying a calculated reduction rate (typically a percentage) to the delivery profile for the preceding period. In this manner, the initial delivery profile is incrementally reduced in steps to ultimately achieve a delivery profile specifying the desired final dosage value.
  • For example, in a preferred embodiment, a clinician may specify a final dosage value and the duration of the reduction interval (which can be expressed in number of periods). Based on this information and the initial dosage information contained in the stored initial delivery profile, a system in accordance with the invention operates to calculate a reduction rate which is then used to periodically reduce the delivery rates until the rates appropriate to the final dosage value are reached.
  • The preferred embodiment also enables the clinician to alternatively specify a periodic (e.g., daily) dosage reduction rate thus enabling the system to then calculate the duration of the reduction interval (e.g., number of days).
  • Although in many applications, it suffices to calculate and reduce delivery rates on a daily basis, it is recognized that for more rapid dosage reduction, or detoxification, delivery rates can be reduced more frequently by partitioning the 24 hour daily period into subperiods of, for example, 2 hours, 4 hours, or 8 hours.
  • BRIEF DESCRIPTION OF THE FIGURES
  • FIG. 1 is a block diagram of an exemplary medical system comprised of an implantable medical device, e.g., a drug delivery device, and an external communication device, or programmer;
  • FIG. 2 is a schematic diagram of an exemplary implantable drug delivery device;
  • FIG. 3A shows an exemplary initial drug delivery profile for a 24 hour period and successive reductions of said profile in accordance with the invention;
  • FIG. 3B plots the daily dosage delivered to the patient with respect to FIG. 3A over the full reduction interval showing a reduction of delivery rate occurring once every 24 hours;
  • FIG. 3C is similar to FIG. 3B but depicts the full reduction of delivery rate occurring once every four hours rather than once per day;
  • FIG. 4 is a flow chart depicting an algorithm executable by an external programmer for producing data for an implanted drug delivery device to enable the device to gradually reduce the dosage, i.e., rate of drug delivery, to the patient; and
  • FIG. 5 is a flow chart executable by the implanted drug delivery device.
  • DETAILED DESCRIPTION
  • Attention is initially directed to FIG. 1 which presents a generalized block diagram of a medical system 10 comprised of at least one medical device 14, e.g., an implantable drug delivery device and an external communication device or programmer 16. The system of FIG. 1 is configured to enable the medical device 14 and the programmer 16 to communicate, e.g., via RF telemetry 17, using telemetry subsystem 18 and telemetry subsystem 19, respectively contained within the devices 14 and 16. The medical device 14 will be assumed herein to comprise a pump implanted in a patient's body for the purpose of delivering a fluid drug to a body site. The programmer 16, on the other hand, is intended to be deployed external to the body and available for use by a physician or clinician or patient to transmit control and/or data signals to the device 14. For example, using the programmer 16, a clinician is able to produce signals which are transmitted via RF link 17 to the medical device 14 to affect its therapeutic performance such as by modifying its drug delivery profile. Systems of the type depicted in FIG. 1, as thus far described are well known. The present invention is directed to a method and apparatus particularly configured to automatically modify a stored delivery profile to reduce the rate of drug delivery to the patient.
  • As depicted in FIG. 1, a typical medical device 14 in system 10 includes an internal power source 20, e.g., a battery, a controller 22 (sometimes hereinafter referred to as a microprocessor), and a memory 24 associated therewith for storing programs and/or data. The microprocessor 22 operates to execute a stored program to control therapeutic subsystem 26 to controllably deliver a drug to a patient's body site. The device 14 may also include an alarm subsystem 28 controllable by microprocessor 22 to alert the patient or clinician of some monitored event.
  • Programmer device 16 is shown as including a controller 34 (sometimes hereinafter referred to as a microprocessor which operates in conjunction with memory 35 which stores programs and/or data. The device 16 optionally includes a user input device 36, e.g., a keyboard, and a user output device 37, e.g., a display. The programmer 16 further include aforementioned telemetry subsystem 19 configured to transmit signals to or receive signals from the medical device telemetry subsystem 18. The programmer 16 may further include an internal power source 38 which can comprise a battery or any other suitable conventional power source.
  • In a typical system 10, the programmer 16 is capable of sending messages to the medical device 14 for use by microprocessor 22 to affect the operation of its therapeutic administration subsystem 26. Additionally, the medical device 14 is typically capable of sending messages to the communication device 16 to report various conditions, e.g., battery status, drug reservoir status, etc. These respective messages sent by the programmer 16 and medical device 14 are handled by the respective telemetry subsystems 19 and 18, each of which is able to transmit and receive RF telemetry signals. Typically, these RF telemetry signals comprise bit streams carried by an RF carrier signal of specified frequency.
  • FIG. 2 illustrates a typical implantable drug delivery device, or pump, 14 comprising a sealed housing 41 defining an interior volume 42. A reservoir 43 for storing a drug to be delivered is mounted in the housing 41 and has an inlet coupled to a fill port 44. A controllable fluid transfer device 45, e.g., a pump or valve mechanism, couples a reservoir outlet via tube 46 to the proximal end 47 of a catheter 48. The catheter distal end 49 is intended to be implanted proximate to a target site in the patient's body for delivering the drug thereto. FIG. 2 also shows a controller 50 for controlling the fluid transfer device 45. Controller 50 corresponds to controller 22 and associated elements shown in device 14 in FIG. 1.
  • In typical use, a hypodermic needle (not shown) is used, via fill port 44, to fill the reservoir 43 with a first drug. The fluid transfer device 45 is controlled by controller 50 in accordance with a stored drug delivery profile comprising a set of data which specifies a schedule of drug flow rates over a certain period, e.g., having a duration of twenty four hours.
  • FIG. 3A depicts an exemplary initial daily drug delivery profile 52 defined by data stored in controller 50. Profile 52 specifies a first delivery rate 53 from 00:00 to 06:00 hours and from 22:00 to 00:00 hours and a second delivery rate 54 from 06:00 to 22:00 hours. The exemplary values of the first and second delivery rates are respectively represented in FIG. 3A as 7 and 8 strokes per minute where “strokes per minute” refers to the activity of pump mechanism 45 (FIG. 2). Thus, it can be seen that the profile 52 will cause the pump to produce 11040 strokes/day (i.e., 7 strokes/minute×60 minutes/hour×8 hours)+(8 strokes/minute×60 minutes/hour×16 hours). If we assume that pump 40 moves 0.25 microliters of drug per stroke, then the drug dosage, or daily quantity delivered to the patient will equal 2.76 milliliters/day (i.e., 11040 strokes×0.25 microliters/stroke).
  • When a dosage reduction operation is initiated in accordance with the present invention, the profile 52 is iteratively processed to successively produce profiles 55, 56, 57, 58, etc. of diminishing amplitude.
  • FIG. 3B depicts the resulting dosage reduction over a multi-day reduction interval. For example, FIG. 3B shows how the daily delivery rate is reduced from an initial value to a final value (shown as zero) over a 14 day interval. Whereas FIG. 3B shows the rate reductions occurring only once per day (i.e., 24 hour period), FIG. 3C demonstrates rate reductions occurring more frequently, e.g., once per 4 hour period.
  • Attention is now directed to FIG. 4 which comprises a flow chart depicting the functioning of programmer 16 when operated by a clinician to run the automatic drug delivery reduction mode in accordance with the present invention. Block 100 functionally represents the patient's periodic (e.g., monthly) visit to the clinician's office for a checkup and/or drug refill. Block 102 represents the programmer 16 initiating communication with the implanted medical device, or pump, 14 to read status data (including the current drug delivery profile) from the pump's memory 24. Block 104 represents the clinician initiating a dosage reduction, i.e., detoxification operational mode in accordance with the invention.
  • Before proceeding with the description of the flow chart of FIG. 4, it would be helpful to define certain terms and mathematically develop the task to be accomplished. Let the following parameters by represented by the indicated terms:
  • D0=Initial daily dosage (ML/day)
  • DN=Daily dosage on day N (ML/day)
  • Rday=Daily reduction rate (%/day)
  • RP=Periodic reduction rate (%/pd.)
  • P=Reduction period (hours)
  • RR=Periodic reduction ratio (1−RP) (%)
  • N=Reduction interval (days)
  • Then

  • D 1 =D 0*(1−R day)

  • D 2 =D 0*(1−R day)*(1−R day)

  • D N =D 0*(1−R day)N  (1)
  • If the initial D0 and final DN daily dosages are known and it is desired that the reduction occur over a fixed reduction interval, equation (1) can be rewritten to find the daily reduction rate.

  • R day=1−(D N /D 0)1/N  (2)
  • If the reduction rate Rday, initial dosage D0, and final dosage DN are known, this equation can be solved for the number of days N.

  • (1−R day)=(D N /D 0)1/N

  • Log(1−R day)=Log(D N /D 0)1/N

  • N Log(1−R day)=Log(D N /D 0)

  • N=Log(D N /D 0)/Log(1−R day)  (3)
  • For rapid dosage reduction, it is possible to reduce the dosage several times a day instead of once a day. If this is done, it is still possible to specify the total daily reduction as either a percentage or a ratio. The following equation shows how to convert from a daily reduction ratio to a reduction ratio that is applied every P hours.
  • From Equation (1):

  • D 1 =D 0*(1−R day) for a daily reduction

  • D 1 =D 0*(1−R P)24/P for a reduction every P hours

  • Therefore:

  • D 0*(1−R day)=D 0*(1−R P)24/P

  • (1−R day)=(1−R P)24/P

  • (1−R day)P/24=(1−R P)

  • R P=1−(1−R day)P/24  (4)
  • The periodic reduction ratio is that fraction by which each delivery rate in the delivery profile is multiplied at the beginning of every reduction interval (P). This is shown in equation (5).

  • R R=(1−R day)P/24  (5)
  • With continuing reference to FIG. 4, block 106 calls for the clinician to enter a final daily dosage value DN and either a daily reduction rate Rday or the reduction interval in days N. Block 108 calls for the programmer microprocessor 34 to read the current dosage value D0 which was retrieved from the pump 14 as part of the current profile in block 104.
  • Decision block 110 asks if the reduction rate Rday was specified. If YES, operation branches to decision block 112 which asks if the final dosage value DN is less than 0.05 times the initial dosage value D0. If YES, block 114 is executed to adjust the final dosage value DN to 0.05 times D0. This operation is performed to terminate profile reduction at a value of DN which is clinically insignificant but greater than zero. If profile reduction were allowed to continue until DN reached zero, the reduction would iterate indefinitely in attempting to asymptotically reach zero. Operation then proceeds to block 116 which computes aforementioned equation (3) to determine the reduction interval N. If decision block 112 yielded a NO, block 114 is skipped.
  • If decision block 110 yields a NO, operation proceeds to block 118 which computes aforementioned equation (2) to determine the daily reduction rate Rday.
  • From either block 116 or 118, operation proceeds to block 120 which computes aforementioned equation (5) to determine the periodic reduction ratio RR. Thereafter (block 122), the programmer 16 transmits various values to reprogram the pump 14 including periodic reduction ratio RR, reduction period P, and the reduction interval N. This action (block 124) completes the activity of the programmer in the execution of the automatic dosage reduction mode in accordance with the invention.
  • Attention is now directed to FIG. 5 which depicts a flow chart describing the operation of the pump microprocessor 22 in the execution of the automatic dosage reduction mode. The flow chart of FIG. 5 starts with block 200 which represents the pump 14 having been reprogrammed by the operation depicted in FIG. 4. Block 201 calculates the number of reduction steps required. For the sake of clarity in explanation, a typical example will be assumed in which the dosage reduction, or detox, interval will have a duration N of fourteen days and the reduction period P will have a duration of four hours. This assumed example (FIG. 3C) will, of course, require eighty four (i.e., N×24/P) reduction steps to reach the desired final dosage value.
  • Block 202 sets a timer (MinutesTillRed) to a count value equal to sixty times the reduction period P. The microprocessor 22 can then sleep (block 204) to conserve power until the beginning of the next minute. The MinutesTillRed count is then decremented by one minute (block 206).
  • Decision block 208 then asks is the MinutesTillRed count equal to zero, or in other words, is it now time to reduce the delivery rate. If NO, operation loops back to block 204. Operation continues to loop through blocks 204, 206, 208 until decision block 208 yields a YES. A YES result from block 208 resets the MinutesTillRed count (block 210) to 60×P.
  • Block 214 then executes one reduction step by multiplying each rate in the current profile by the periodic reduction ratio RR; i.e., Rate (n)=Rate (n) times RR. Since RR always has a value less than one, this multiplication will, of course, reduce the value of Rate (n) in the up-dated current profile.
  • Block 216 then decrements the RedStop count by one. Block 218 then asks if the RedStop count is equal to zero. If NO, operation loops back to block 204. If YES, operation proceeds to block 220 which allows the pump 14 to continue to deliver drug in accordance with the current updated profile.
  • From the foregoing, it should now be understood that a drug delivery apparatus and method of operation has been disclosed herein for automatically and gradually reducing delivery rates. Although only a single preferred exemplary embodiment has been described, it is intended that the appended claims be interpreted to encompass variations and modifications which will be apparent to those persons skilled in the art.

Claims (24)

1-16. (canceled)
17. An implantable drug delivery device, comprising:
an implantable housing configured for implantation into a body;
a reservoir within the implantable housing;
a fluid transfer device within the implantable housing in fluidic communication with the reservoir; and
means, carried within the implantable housing, for repeatedly modifying an entire stored delivery profile including at least one delivery rate in response to a single receipt of modification data.
18. An implantable drug delivery device as claimed in claim 17, wherein the stored delivery profile includes at least two different delivery rates.
19. An implantable drug delivery device as claimed in claim 17, wherein the stored delivery profile includes a plurality of delivery rates, at least two of which are different, that are associated with respective portions of a 24-hour period.
20. An implantable drug delivery device as claimed in claim 17, wherein the stored delivery profile comprises a delivery profile for a 24-hour period.
21. An implantable drug delivery device as claimed in claim 17, wherein the at least one delivery rate is defined in terms of pump strokes.
22. An implantable drug delivery device as claimed in claim 17, wherein the modification data comprises a reduction ratio having a value that is less than 1.
23. A method of operating an implantable drug delivery device, comprising the step of:
repeatedly modifying a delivery profile that includes a plurality of delivery rates and is stored within the implantable drug delivery device with the implantable drug delivery device in response to a single receipt of wirelessly transmitted modification data.
24. A method as claimed in claim 23, further comprising the step of:
receiving wirelessly transmitted modification data with the implantable drug delivery device while the entire implantable drug delivery device is carried within a patient's body.
25. A method as claimed in claim 23, wherein the step of repeatedly modifying a stored delivery profile comprises performing the following steps with the implantable drug delivery device in response to a single receipt of wirelessly transmitted modification data:
(1) creating a modified delivery profile by reducing the delivery rates in the stored delivery profile,
(2) storing the modified delivery profile for a predetermined period, and
(3) repeating steps (1) and (2) after the expiration of the predetermined period.
26. A method as claimed in claim 25, wherein the predetermined period is at least about 2 hours.
27. A method as claimed in claim 25, wherein the predetermined period is between about 2 hours and about 24 hours.
28. A method as claimed in claim 25, wherein
the modification data comprises a reduction ratio having a value less than 1.0; and
the step of creating a modified delivery profile comprises multiplying the delivery rates in the delivery profile by the reduction ratio.
29. A method as claimed in claim 25, wherein
the step of repeating steps (1) and (2) comprises repeating steps (1) and (2) after the expiration of the predetermined period a plurality of times over the course of a plurality of days in response to a single receipt of wirelessly transmitted modification data.
30. A method of modifying the dosage of a drug supplied by a drug delivery device that stores a delivery profile including at least one delivery rate and is located entirely within a patient, the method comprising the steps of:
wirelessly transmitting a final daily dosage value to the drug delivery device located entirely within the patient;
wirelessly transmitting a reduction rate or a reduction interval to the drug delivery device located entirely within the patient; and
allowing the drug delivery device located entirely within the patient to itself iteratively reduce the at least one delivery rate over the course of a plurality of days as a function of the transmitted final daily dosage value and the transmitted reduction rate or as a function of the transmitted final daily dosage value and the transmitted reduction interval.
31. A method as claimed in claim 30, wherein the final dosage value is expressed in terms of volume per time period.
32. A method as claimed in claim 30, wherein the final dosage value is expressed in terms of volume per day.
33. A method as claimed in claim 30, wherein the reduction rate is expressed as a percentage reduction per time period or a reduction ratio per time period.
34. A method as claimed in claim 30, wherein the reduction rate is expressed as a percentage reduction per day or a reduction ratio per day.
35. A method as claimed in claim 30, wherein the reduction interval is expressed in days.
36. A method of operating an implantable drug delivery device, comprising the steps of:
initiating a dosage reduction mode in response to a single event; and
modifying a delivery profile that includes one or more clinically significant delivery rates and is stored within the implantable drug delivery device by reducing the one or more clinically significant delivery rates to one or more lower clinically significant delivery rates with the implantable drug delivery device in response to the initiation of the dosage reduction mode.
37. A method as claimed in claim 36, where in the step of initiating a dosage reduction mode comprises initiating a dosage reduction mode in response to a single receipt of wirelessly transmitted modification data.
38. A method as claimed in claim 36, where in the step of modifying a delivery profile comprises repeatedly modifying a delivery profile that includes one or more clinically significant delivery rates and is stored within the implantable drug delivery device by reducing the one or more clinically significant delivery rates to one or more lower clinically significant delivery rates with the implantable drug delivery device in response to the initiation of the dosage reduction mode.
39. A method as claimed in claim 36, where in the step of modifying a delivery profile comprises modifying a delivery profile that includes a plurality of clinically significant delivery rates and is stored within the implantable drug delivery device by reducing the plurality of clinically significant delivery rates to a plurality of lower clinically significant delivery rates with the implantable drug delivery device in response to the initiation of the dosage reduction mode.
US11/929,401 2004-08-27 2007-10-30 Drug Delivery Apparatus and Method for Automatically Reducing Drug Dosage Abandoned US20080172044A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US60499904P true 2004-08-27 2004-08-27
US11/182,307 US20060047270A1 (en) 2004-08-27 2005-07-14 Drug delivery apparatus and method for automatically reducing drug dosage
US11/929,401 US20080172044A1 (en) 2004-08-27 2007-10-30 Drug Delivery Apparatus and Method for Automatically Reducing Drug Dosage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/929,401 US20080172044A1 (en) 2004-08-27 2007-10-30 Drug Delivery Apparatus and Method for Automatically Reducing Drug Dosage

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/182,307 Continuation US20060047270A1 (en) 2004-03-02 2005-07-14 Drug delivery apparatus and method for automatically reducing drug dosage

Publications (1)

Publication Number Publication Date
US20080172044A1 true US20080172044A1 (en) 2008-07-17

Family

ID=46322269

Family Applications (4)

Application Number Title Priority Date Filing Date
US11/182,307 Abandoned US20060047270A1 (en) 2004-03-02 2005-07-14 Drug delivery apparatus and method for automatically reducing drug dosage
US11/929,401 Abandoned US20080172044A1 (en) 2004-08-27 2007-10-30 Drug Delivery Apparatus and Method for Automatically Reducing Drug Dosage
US13/281,432 Active US8747390B2 (en) 2004-08-27 2011-10-26 Drug delivery apparatus and method for automatically reducing drug dosage
US14/278,194 Active 2025-09-08 US9463273B2 (en) 2004-08-27 2014-05-15 Drug delivery apparatus and method for automatically reducing drug dosage

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US11/182,307 Abandoned US20060047270A1 (en) 2004-03-02 2005-07-14 Drug delivery apparatus and method for automatically reducing drug dosage

Family Applications After (2)

Application Number Title Priority Date Filing Date
US13/281,432 Active US8747390B2 (en) 2004-08-27 2011-10-26 Drug delivery apparatus and method for automatically reducing drug dosage
US14/278,194 Active 2025-09-08 US9463273B2 (en) 2004-08-27 2014-05-15 Drug delivery apparatus and method for automatically reducing drug dosage

Country Status (1)

Country Link
US (4) US20060047270A1 (en)

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060047270A1 (en) * 2004-08-27 2006-03-02 Shelton Brian M Drug delivery apparatus and method for automatically reducing drug dosage
US20090271215A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for detecting a bioactive agent effect
US20090271121A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for detecting a bioactive agent effect
US20090271122A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring and modifying a combination treatment
US20090271120A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring bioactive agent use
US20090271219A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The Stste Of Delaware Methods and systems for presenting a combination treatment
US20090271375A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Combination treatment selection methods and systems
US20090270786A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting a combination treatment
US20090270693A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for modifying bioactive agent use
US20090319301A1 (en) * 2008-04-24 2009-12-24 Searete Llc, A Limited Liability Corporation Of The State Of Delawar Methods and systems for presenting a combination treatment
US20100004762A1 (en) * 2008-04-24 2010-01-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100015583A1 (en) * 2008-04-24 2010-01-21 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational System and method for memory modification
US20100030089A1 (en) * 2008-04-24 2010-02-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring and modifying a combination treatment
US20100042578A1 (en) * 2008-04-24 2010-02-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100076249A1 (en) * 2008-04-24 2010-03-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100081860A1 (en) * 2008-04-24 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational System and Method for Memory Modification
US20100169260A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US20100164729A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US20100166613A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100168529A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163038A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100169259A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163037A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delware Methods and systems for presenting an inhalation experience
US20100163033A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163034A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163028A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163026A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163024A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Methods and systems for presenting an inhalation experience
US20100163025A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US20100163027A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163035A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US20100168602A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US20100163036A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US7801686B2 (en) 2008-04-24 2010-09-21 The Invention Science Fund I, Llc Combination treatment alteration methods and systems
US7974787B2 (en) 2008-04-24 2011-07-05 The Invention Science Fund I, Llc Combination treatment alteration methods and systems
US8876688B2 (en) 2008-04-24 2014-11-04 The Invention Science Fund I, Llc Combination treatment modification methods and systems
US9064036B2 (en) 2008-04-24 2015-06-23 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US9239906B2 (en) 2008-04-24 2016-01-19 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US9449150B2 (en) 2008-04-24 2016-09-20 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US9560967B2 (en) 2008-04-24 2017-02-07 The Invention Science Fund I Llc Systems and apparatus for measuring a bioactive agent effect
US9662391B2 (en) 2008-04-24 2017-05-30 The Invention Science Fund I Llc Side effect ameliorating combination therapeutic products and systems

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9123077B2 (en) 2003-10-07 2015-09-01 Hospira, Inc. Medication management system
US20060264897A1 (en) * 2005-01-24 2006-11-23 Neurosystec Corporation Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
US20060280655A1 (en) * 2005-06-08 2006-12-14 California Institute Of Technology Intravascular diagnostic and therapeutic sampling device
US8444609B2 (en) 2006-04-28 2013-05-21 Medtronic, Inc. Implantable therapeutic substance delivery system with catheter access port block and method of use
US8267905B2 (en) 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
US20080152694A1 (en) * 2006-07-20 2008-06-26 Neurosystec Corporation Devices, Systems and Methods for Ophthalmic Drug Delivery
US20080145439A1 (en) * 2006-07-31 2008-06-19 Neurosystec Corporation Nanoparticle drug formulations
US20080091466A1 (en) 2006-10-16 2008-04-17 Hospira, Inc. System and method for comparing and utilizing activity information and configuration information from multiple device management systems
WO2009092067A2 (en) * 2008-01-18 2009-07-23 Neurosystec Corporation Valveless impedance pump drug delivery systems
US8271106B2 (en) 2009-04-17 2012-09-18 Hospira, Inc. System and method for configuring a rule set for medical event management and responses
US8771251B2 (en) 2009-12-17 2014-07-08 Hospira, Inc. Systems and methods for managing and delivering patient therapy through electronic drug delivery systems
MX356030B (en) * 2011-01-31 2018-05-09 Fresenius Medical Care Holdings Inc Preventing over-delivery of drug.
EP2745204A4 (en) 2011-08-19 2015-01-07 Hospira Inc Systems and methods for a graphical interface including a graphical representation of medical data
AU2012325937B2 (en) 2011-10-21 2018-03-01 Icu Medical, Inc. Medical device update system
WO2013090709A1 (en) 2011-12-16 2013-06-20 Hospira, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
JP6306566B2 (en) 2012-03-30 2018-04-04 アイシーユー・メディカル・インコーポレーテッド Air detection system and method for detecting air in an infusion system pump
EP2879733B1 (en) 2012-07-31 2019-06-05 ICU Medical, Inc. Patient care system for critical medications
EP2964079A4 (en) 2013-03-06 2016-11-23 Hospira Inc Medical device communication method
AU2014268355B2 (en) 2013-05-24 2018-06-14 Icu Medical, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system
WO2014194089A1 (en) 2013-05-29 2014-12-04 Hospira, Inc. Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system
US10311972B2 (en) 2013-11-11 2019-06-04 Icu Medical, Inc. Medical device system performance index
WO2015077320A1 (en) 2013-11-19 2015-05-28 Hospira, Inc. Infusion pump automation system and method
WO2015131108A2 (en) 2014-02-28 2015-09-03 Hospira, Inc. Infusion system and method which utilizes dual wavelength optical air-in-line detection
US9724470B2 (en) 2014-06-16 2017-08-08 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
US9539383B2 (en) 2014-09-15 2017-01-10 Hospira, Inc. System and method that matches delayed infusion auto-programs with manually entered infusion programs and analyzes differences therein

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443218A (en) * 1982-09-09 1984-04-17 Infusaid Corporation Programmable implantable infusate pump
US4457751A (en) * 1980-05-16 1984-07-03 Rodler Ing Hans Automatic infusion pump
US4785799A (en) * 1985-08-08 1988-11-22 American Hospital Supply Corporation Method and apparatus for automatic profiled infusion in cyclic TPN
US5084021A (en) * 1990-11-02 1992-01-28 Baldwin Brian E Patient controlled infusion apparatus and method
US5119832A (en) * 1989-07-11 1992-06-09 Ravi Xavier Epidural catheter with nerve stimulators
US5178603A (en) * 1990-07-24 1993-01-12 Baxter International, Inc. Blood extraction and reinfusion flow control system and method
US5219330A (en) * 1991-11-26 1993-06-15 Imed Corporation Method and apparatus for preprogrammed infusion of iv medicaments
US5458631A (en) * 1989-01-06 1995-10-17 Xavier; Ravi Implantable catheter with electrical pulse nerve stimulators and drug delivery system
US5468222A (en) * 1990-05-03 1995-11-21 Mayo Foundation For Medical Education & Research Process for determining drug taper schedules
US5609575A (en) * 1994-04-11 1997-03-11 Graseby Medical Limited Infusion pump and method with dose-rate calculation
US6231560B1 (en) * 1999-02-10 2001-05-15 Baxter International Inc Method and apparatus for automatically controlling the level of medication
US6261267B1 (en) * 1998-10-09 2001-07-17 Globe Enterprises, Inc. Automatic IV shut off valve
US20030036744A1 (en) * 2000-05-03 2003-02-20 Aspect Medical Systems, Inc. System and method for adaptive drug delivery
US20030050621A1 (en) * 2001-09-07 2003-03-13 Lebel Ronald J. Safety limits for closed-loop infusion pump control
US6562001B2 (en) * 2000-01-21 2003-05-13 Medtronic Minimed, Inc. Microprocessor controlled ambulatory medical apparatus with hand held communication device
US6579280B1 (en) * 1999-04-30 2003-06-17 Medtronic, Inc. Generic multi-step therapeutic treatment protocol
US20060047270A1 (en) * 2004-08-27 2006-03-02 Shelton Brian M Drug delivery apparatus and method for automatically reducing drug dosage
US7031772B2 (en) * 2002-04-29 2006-04-18 Medtronic, Inc. Method and apparatus for rate responsive adjustments in an implantable medical device

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923060A (en) * 1974-04-23 1975-12-02 Jr Everett H Ellinwood Apparatus and method for implanted self-powered medication dispensing having timing and evaluator means
CA1129811A (en) * 1978-03-28 1982-08-17 Diamond Shamrock Technologies S.A. Electrode with coating of manganese dioxide and platinum for electrowinning
US4373527B1 (en) * 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
EP0649316B2 (en) * 1992-10-15 2013-08-28 The General Hospital Corporation An infusion pump with an electronically loadable drug library
US5685844A (en) * 1995-01-06 1997-11-11 Abbott Laboratories Medicinal fluid pump having multiple stored protocols
US6010483A (en) * 1996-12-23 2000-01-04 Spencer; Robert F. Patient controlled analgesia device for use with ultrashort acting opioid medication and method for using the same
JP4187085B2 (en) * 2001-08-24 2008-11-26 三菱電機株式会社 Vehicle occupant protection device
US20030204274A1 (en) * 2002-04-26 2003-10-30 Medtronic, Inc. Patient controlled activation with implantable drug delivery devices

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4457751A (en) * 1980-05-16 1984-07-03 Rodler Ing Hans Automatic infusion pump
US4443218A (en) * 1982-09-09 1984-04-17 Infusaid Corporation Programmable implantable infusate pump
US4785799A (en) * 1985-08-08 1988-11-22 American Hospital Supply Corporation Method and apparatus for automatic profiled infusion in cyclic TPN
US5458631A (en) * 1989-01-06 1995-10-17 Xavier; Ravi Implantable catheter with electrical pulse nerve stimulators and drug delivery system
US5119832A (en) * 1989-07-11 1992-06-09 Ravi Xavier Epidural catheter with nerve stimulators
US5468222A (en) * 1990-05-03 1995-11-21 Mayo Foundation For Medical Education & Research Process for determining drug taper schedules
US5178603A (en) * 1990-07-24 1993-01-12 Baxter International, Inc. Blood extraction and reinfusion flow control system and method
US5084021A (en) * 1990-11-02 1992-01-28 Baldwin Brian E Patient controlled infusion apparatus and method
US5219330A (en) * 1991-11-26 1993-06-15 Imed Corporation Method and apparatus for preprogrammed infusion of iv medicaments
US5609575A (en) * 1994-04-11 1997-03-11 Graseby Medical Limited Infusion pump and method with dose-rate calculation
US6261267B1 (en) * 1998-10-09 2001-07-17 Globe Enterprises, Inc. Automatic IV shut off valve
US6231560B1 (en) * 1999-02-10 2001-05-15 Baxter International Inc Method and apparatus for automatically controlling the level of medication
US6579280B1 (en) * 1999-04-30 2003-06-17 Medtronic, Inc. Generic multi-step therapeutic treatment protocol
US6562001B2 (en) * 2000-01-21 2003-05-13 Medtronic Minimed, Inc. Microprocessor controlled ambulatory medical apparatus with hand held communication device
US20030036744A1 (en) * 2000-05-03 2003-02-20 Aspect Medical Systems, Inc. System and method for adaptive drug delivery
US6599281B1 (en) * 2000-05-03 2003-07-29 Aspect Medical Systems, Inc. System and method for adaptive drug delivery
US20030050621A1 (en) * 2001-09-07 2003-03-13 Lebel Ronald J. Safety limits for closed-loop infusion pump control
US7031772B2 (en) * 2002-04-29 2006-04-18 Medtronic, Inc. Method and apparatus for rate responsive adjustments in an implantable medical device
US20060047270A1 (en) * 2004-08-27 2006-03-02 Shelton Brian M Drug delivery apparatus and method for automatically reducing drug dosage

Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060047270A1 (en) * 2004-08-27 2006-03-02 Shelton Brian M Drug delivery apparatus and method for automatically reducing drug dosage
US8747390B2 (en) 2004-08-27 2014-06-10 Medallion Therapeutics, Inc. Drug delivery apparatus and method for automatically reducing drug dosage
US9463273B2 (en) 2004-08-27 2016-10-11 Medallion Therapeutics, Inc. Drug delivery apparatus and method for automatically reducing drug dosage
US7974787B2 (en) 2008-04-24 2011-07-05 The Invention Science Fund I, Llc Combination treatment alteration methods and systems
US20090271120A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring bioactive agent use
US20090271219A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The Stste Of Delaware Methods and systems for presenting a combination treatment
US20090271375A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Combination treatment selection methods and systems
US20090271122A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring and modifying a combination treatment
US20090270693A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for modifying bioactive agent use
US20090319301A1 (en) * 2008-04-24 2009-12-24 Searete Llc, A Limited Liability Corporation Of The State Of Delawar Methods and systems for presenting a combination treatment
US20100004762A1 (en) * 2008-04-24 2010-01-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100015583A1 (en) * 2008-04-24 2010-01-21 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational System and method for memory modification
US20100030089A1 (en) * 2008-04-24 2010-02-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring and modifying a combination treatment
US20100042578A1 (en) * 2008-04-24 2010-02-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100076249A1 (en) * 2008-04-24 2010-03-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100081860A1 (en) * 2008-04-24 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational System and Method for Memory Modification
US9649469B2 (en) 2008-04-24 2017-05-16 The Invention Science Fund I Llc Methods and systems for presenting a combination treatment
US9560967B2 (en) 2008-04-24 2017-02-07 The Invention Science Fund I Llc Systems and apparatus for measuring a bioactive agent effect
US9504788B2 (en) 2008-04-24 2016-11-29 Searete Llc Methods and systems for modifying bioactive agent use
US20090271121A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for detecting a bioactive agent effect
US9449150B2 (en) 2008-04-24 2016-09-20 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US8606592B2 (en) 2008-04-24 2013-12-10 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US9358361B2 (en) 2008-04-24 2016-06-07 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US9282927B2 (en) 2008-04-24 2016-03-15 Invention Science Fund I, Llc Methods and systems for modifying bioactive agent use
US9239906B2 (en) 2008-04-24 2016-01-19 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US9064036B2 (en) 2008-04-24 2015-06-23 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US9026369B2 (en) 2008-04-24 2015-05-05 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US8930208B2 (en) 2008-04-24 2015-01-06 The Invention Science Fund I, Llc Methods and systems for detecting a bioactive agent effect
US20090270786A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting a combination treatment
US8876688B2 (en) 2008-04-24 2014-11-04 The Invention Science Fund I, Llc Combination treatment modification methods and systems
US20090271215A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for detecting a bioactive agent effect
US8682687B2 (en) 2008-04-24 2014-03-25 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US8615407B2 (en) 2008-04-24 2013-12-24 The Invention Science Fund I, Llc Methods and systems for detecting a bioactive agent effect
US7801686B2 (en) 2008-04-24 2010-09-21 The Invention Science Fund I, Llc Combination treatment alteration methods and systems
US9662391B2 (en) 2008-04-24 2017-05-30 The Invention Science Fund I Llc Side effect ameliorating combination therapeutic products and systems
US20100163025A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US20100163036A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100168602A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US8694330B2 (en) 2008-12-30 2014-04-08 The Invention Science Fund I, Llc Methods and systems for presenting an inhalation experience
US8706518B2 (en) 2008-12-30 2014-04-22 The Invention Science Fund I, Llc Methods and systems for presenting an inhalation experience
US8712794B2 (en) 2008-12-30 2014-04-29 The Invention Science Fund I, Llc Methods and systems for presenting an inhalation experience
US8725529B2 (en) 2008-12-30 2014-05-13 The Invention Science Fund I, Llc Methods and systems for presenting an inhalation experience
US8738395B2 (en) 2008-12-30 2014-05-27 The Invention Science Fund I, Llc Methods and systems for presenting an inhalation experience
US20100163035A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US20100163027A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163024A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Methods and systems for presenting an inhalation experience
US20100163026A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163028A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163034A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163033A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163037A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delware Methods and systems for presenting an inhalation experience
US20100163038A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100168529A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100166613A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100164729A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US20100169260A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US20100169259A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience

Also Published As

Publication number Publication date
US9463273B2 (en) 2016-10-11
US20140364839A1 (en) 2014-12-11
US20060047270A1 (en) 2006-03-02
US8747390B2 (en) 2014-06-10
US20120277732A1 (en) 2012-11-01

Similar Documents

Publication Publication Date Title
US8758308B2 (en) Infusion device pump
CA1274737A (en) Method and apparatus for automatic profiled infusion in cyclic tpn
DK2044544T3 (en) Fluid administration and methods of using it
EP1427471B1 (en) Plunger for patient infusion device
US8088098B2 (en) Tailored basal insulin delivery system and method
US6589205B1 (en) Externally-controllable constant-flow medication delivery system
JP3939661B2 (en) Medical communication system
ES2307514T3 (en) Appliance to provide continuous positive airway pressure.
US5871478A (en) Implantable drug delivery means
US5876370A (en) Intermittent fluid delivery apparatus and method
EP1109586B2 (en) External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US7054782B2 (en) Non-conformance monitoring and control techniques for an implantable medical device
CA1169323A (en) Insulin infusion device
US6231560B1 (en) Method and apparatus for automatically controlling the level of medication
US5885245A (en) Medical apparatus with remote virtual input device
US20080208627A1 (en) Securing Pairing of Electronic Devices
US7505869B2 (en) Non-conformance monitoring and control techniques for an implantable medical device
US5368562A (en) Systems and methods for operating ambulatory medical devices such as drug delivery devices
US4282872A (en) Device for the pre-programmable infusion of liquids
JP5065042B2 (en) System and method for coordinating wireless communication between implantable medical devices
US5895371A (en) Medical treatment apparatus and method
US10049768B2 (en) Programmable insulin pump
US20030212379A1 (en) Systems and methods for remotely controlling medication infusion and analyte monitoring
JP2019058713A (en) Extended use medical device
US20040225252A1 (en) System and method for operating an infusion pump

Legal Events

Date Code Title Description
AS Assignment

Owner name: INFUSION SYSTEMS, LLC, CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BOSTON SCIENTIFIC NEUROMODULATION CORPORATION;REEL/FRAME:020329/0853

Effective date: 20080107

AS Assignment

Owner name: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION, CAL

Free format text: CHANGE OF NAME;ASSIGNOR:ADVANCED BIONICS CORPORATION;REEL/FRAME:020796/0264

Effective date: 20071116

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION