Connect public, paid and private patent data with Google Patents Public Datasets

Bone implant having engineered surfaces

Download PDF

Info

Publication number
US20080154378A1
US20080154378A1 US11615158 US61515806A US2008154378A1 US 20080154378 A1 US20080154378 A1 US 20080154378A1 US 11615158 US11615158 US 11615158 US 61515806 A US61515806 A US 61515806A US 2008154378 A1 US2008154378 A1 US 2008154378A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
bone
engaging
implant
protrusions
interface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11615158
Inventor
Mark J. Pelo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warsaw Orthopedic Inc
Original Assignee
Warsaw Orthopedic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86Threaded wires, pins or screws; Nuts therefor
    • A61B17/866Material or manufacture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442Intervertebral or spinal discs, e.g. resilient
    • A61F2/4425Intervertebral or spinal discs, e.g. resilient made of articulated components
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • A61F2002/2817Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30621Features concering the anatomical functioning or articulation of the prosthetic joint
    • A61F2002/30649Ball-and-socket joints
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves
    • A61F2002/3082Grooves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves
    • A61F2002/3082Grooves
    • A61F2002/30823Grooves having the shape of a reverse dovetail
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves
    • A61F2002/30841Sharp anchoring protrusions for impaction into the bone, e.g. sharp pins, spikes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves
    • A61F2002/30878Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A61F2002/30879Ribs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves
    • A61F2002/30878Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A61F2002/30884Fins or wings, e.g. longitudinal wings for preventing rotation within the bone cavity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves
    • A61F2002/30878Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A61F2002/30899Protrusions pierced with apertures
    • A61F2002/30902Protrusions pierced with apertures laterally or radially
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00029Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389The prosthesis being coated or covered with a particular material
    • A61F2310/00592Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite

Abstract

The present disclosure is directed to an implantable device that is machined to have a bone engaging interface defining cavities that may be deposited with bone growth promoting material.

Description

    BACKGROUND
  • [0001]
    Severe back pain and nerve damage may be caused by injured, degraded, or diseased spinal joints and, particularly, spinal discs. Similarly, hip and knee pain can be caused by injured, degraded, or diseased hip and knee joints. For example, disc deterioration and other spinal deterioration may cause spinal stenosis, a narrowing of the spinal canal and/or the intervertebral foramen, that causes pinching of the spinal cord and associated nerves. Severe hip joint degradation, for example, can often require implantation of a hip implant in what is commonly referred to as a hip replacement surgery.
  • [0002]
    Current methods of treating damaged spinal discs include vertebral fusion, nucleus replacements, or motion preservation prostheses. A spinal prostheses joint, such as that described U.S. Pat. No. 6,740,118, the disclosure of which is incorporated herein by reference, for example, is placed between two vertebral bodies to maintain or restore motion similar to the normal motion provided by natural intervertebral joints. Artificial disc implants, such as described in U.S. Pat. No. 6,402,785, the disclosure of which is incorporated herein by reference, have also been used as a disc replacement therapy. Other spinal therapies include fixation systems whereby bone screws, for example, are inserted into vertebral bodies and a connecting rod is secured between the screws to provide spinal stability, such as that described in U.S. Pat. No. 6,454,773, the disclosure of which is incorporated herein by reference.
  • [0003]
    Generally, surfaces of these implant and other bone-related implant devices are roughened and coated with a bone-growth promoting material, such as Infuse®, which is commercially available from Medtronic, Inc. of Minneapolis, Minn., hydroxyapatite, or other similar bone-growth promoting material. INFUSE is a registered trademark of Medronic Sofamor Danek, Inc, Minneapolis, Minn. Chemical etching, plasma spraying, and porous coating are typically used to roughen the bone engaging surfaces of the implants. With conventional roughening techniques, the roughened surface is randomly patterned. As a result, there is little control in defining the surface pattern or bone engaging interface. Therefore, there is a need for bone implants with engineered surfaces to provide controlled bone growth interfaces.
  • SUMMARY
  • [0004]
    In one aspect, this disclosure is directed to an implant having a body and a bone engaging interface. The bone engaging interface is formed on a portion of the body and is shaped to favor movement of the implant in a first direction and to resist movement in a second direction opposite the first direction.
  • [0005]
    In another aspect, this disclosure is directed to an intervertebral prosthetic joint that has a first articular component and a second articular component. A first bone engaging surface is defined on a portion of the first articular component and a second bone engaging surface is defined on a portion of the second articular component. Each bone engaging surface provides a migration promoting interface along a first direction and provides an anti-migratory interface along a second direction opposite the first direction.
  • [0006]
    According to another aspect, this disclosure is directed to an artificial implant having an implant body that includes a bone engaging interface. Cavities are formed by laser machining a portion of the bone engaging surface of the implant body. Bone growth material is then deposited in the cavities.
  • [0007]
    In yet another aspect, this disclosure is directed to a surgical method for positioning an intervertebral implant. The method includes preparing a disc space for reception of an intervertebral implant. An intervertebral implant is inserted along a first direction into the disc space. The intervertebral implant is then withdrawn from the disc space generally along a second direction opposite the first direction. The implant is withdrawn from the disc space until the implant engages a vertebral body defining the disc space.
  • [0008]
    This disclosure is also directed to a method of manufacturing an implant. The manufacturing process includes the formation of an implant body. The implant body is laser machined to define a plurality of protrusions and cavities. Bone growth promoting material is deposited into the cavities.
  • [0009]
    In another aspect, this disclosure is directed to a bone screw. The bone screw has a shaft and a plurality of threads formed thereon. A bone ingrowth cavity is formed in the shaft in a space between a pair of threads.
  • [0010]
    These and other aspects, forms, objects, features, and benefits of the present invention will become apparent from the following detailed drawings and descriptions.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0011]
    FIG. 1 is a perspective view of an intervertebral prosthetic joint according to one aspect of the present disclosure.
  • [0012]
    FIG. 2 is a plan view of a portion of the intervertebral prosthetic joint shown in FIG. 1.
  • [0013]
    FIG. 3 is a cross-sectional view of a portion of that shown in FIG. 2 taken along lines 3-3.
  • [0014]
    FIG. 4 is a cross-sectional view of a portion of a bone engaging interface according to another example of the present disclosure.
  • [0015]
    FIG. 5 is a cross-sectional view of a portion of a bone engaging interface according to yet another example of the present disclosure.
  • [0016]
    FIG. 6 is a cross-sectional view of a portion of a bone engaging interface according to a further example of the present disclosure.
  • [0017]
    FIG. 7 is a perspective view of a portion of a bone engaging interface according to yet another example of the present disclosure.
  • [0018]
    FIG. 8 is an elevation view of a bone screw according to one example of the present disclosure.
  • [0019]
    FIG. 9 is an exploded view of a portion of the bone screw of FIG. 8.
  • DETAILED DESCRIPTION
  • [0020]
    The present disclosure relates generally to the field of orthopedic surgery, and more particularly to systems and methods for replacing or stabilizing a spinal joint. For the purposes of promoting an understanding of the principles of the invention, reference will now be made to embodiments or examples illustrated in the drawings, and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended. Any alteration and further modifications in the described embodiments, and any further applications of the principles of the invention as described herein are contemplated as would normally occur to one skilled in the art to which the disclosure relates. While the present disclosure will be described with respect to spinal or vertebral implants, it is understood that the present disclosure is also applicable with other implant types, such as hip or knee implants.
  • [0021]
    Referring to FIG. 1, a intervertebral prosthetic joint incorporating aspects of the present disclosure is shown. The intervertebral prosthetic joint is similar to that described in U.S. Pat. No. 6,740,118, the disclosure of which is incorporated herein by reference. Joint 10 has two articular components 12, 14 that cooperate to provide rotational and pivotal movement between vertebral members. The joint 10 is designed to simulate the bio-mechanical motion provided by a natural intervertebral disc.
  • [0022]
    The articular components 12, 14 are permitted to pivot relative to one another about a number of axes, including lateral or side-to-side pivotal movement about longitudinal axis L and anterior-posterior pivotal movement about a transverse axis T. In a preferred embodiment of the invention, the articular components 12, 14 are permitted to pivot relative to one another about any axes that lies in a plane that intersects longitudinal axis L and transverse axis T. Additionally, the articular components 12, 14 are preferably permitted to rotate relative to one another about a rotational axis R. Although the articulating joint 10 has been illustrated and described as providing a specific combination of articulating motion, it should be understood that other combinations of articulating movement are also possible and are contemplated as falling within the scope of the present invention. It should also be understood that other types of articulating movement are also contemplated, such as, for example, relative translational or linear motion.
  • [0023]
    Although the articular components 12, 14 of prosthetic joint 10 may be formed from a wide variety of materials, in one embodiment of the invention, the articular components 12, 14 are formed of a cobalt-chrome-molybdenum metallic alloy (ASTM F799 or F-75). However, in alternative embodiments of the invention, the articular components 12, 14 may be formed of other bio-compatible metallic materials such as titanium or stainless steel, a bio-compatible polymeric material such as polyethylene, or any other biocompatible material that would be apparent to one of ordinary skill in the art. The surfaces of the articular components 12, 14 that are positioned in direct contact with vertebral bone are preferably coated with a bone-growth promoting substance, such as, for example, a hydroxyapatite coating formed of calcium phosphate. Additionally, the surface of the articular components 12, 14 that are positioned in direct contact with vertebral bone include bone growth promoting interfaces, which will be described in greater detail below.
  • [0024]
    Articular component 12 includes a support plate 16 having an articular surface 18 and an opposite bearing or bone engaging surface 20. Support plate 16 is sized and shaped to substantially correspond to the size and shape of an end plate of an adjacent vertebra (not shown). The articular component 12 also includes a tool engaging groove 22 defined between the articular surface 18 and the bone engaging surface 20, and is designed to receive a tool or other instrument to aid in the placement of the joint between vertebral members.
  • [0025]
    Articular component 12 includes a concave recess (not shown) formed in the convex articular surface 18 of support plate 16. Preferably, the concave recess has a semi-spherical shape sized to receive a correspondingly shaped projection 24 of articular component 14. Projection 24 extends from substantially planar articular surface 26 of support plate 28 of articular component 14. Opposite of articular surface 26 is bearing or bone engaging surface 30. Similar to articular component 12, a groove 32 designed to receive a corresponding portion of a surgical tool or instrument is formed between the articular surface 26 and bone engaging surface 30 in support plate 28. Extending from the respective bone engaging surfaces 20, 30 of articular components 12, 14 are flange members or keels 32, 34. The keels are sized to fit within an opening formed in adjacent vertebral endplates (not shown). The keels preferably extend perpendicularly from the bone engaging surfaces and are centrally disposed so as to divide the respective bone engaging surfaces in half. Each keel preferably includes a pair of openings 36, 38 to facilitate bone-through growth to promote fixation to adjacent vertebra. While only two openings are shown, it is contemplated that the keels may be constructed to have any number of openings. Additionally, while only a single respective keel is shown extending from the bone engaging surfaces, it is contemplated that the joint may be constructed to have any number of keels, and those keels can be of different shapes and/or sizes.
  • [0026]
    Articular component 14 also includes a tool engaging groove 40 similar to that of articular component 12. Groove 40 is designed to receive a tool or other instrument to aid in the placement of the joint between vertebral bodies.
  • [0027]
    As referenced above, the bone engaging surfaces of the articular components provide a bone engaging interface that can be deposited with bone growth promoting or cellular material. In a preferred example, the bone engaging surfaces are machined, using a laser, for instance, to provide a controlled interface that, for example, can include cavities, recesses, grooves, and the like for housing seeds of bone growth promoting material. In another example, the bone engaging interfaces can be formed to favor movement of the joint in one direction but resist movement of the joint in an opposite direction. Laser machining the bone engaging surfaces of the joint provides a textured surface that, unlike chemical etching or plasma spraying, for example, is not necessarily random and thus can be used to develop a pre-defined bone engaging interface. In one example, a pulsing Nd:YV04 laser is used to machine the bone engaging surfaces of the joint. However, it is recognized that other lasers may be used. It also recognized that the bone engaging surfaces may be machined using Electrical Discharge Machining (EDM) or other machining techniques.
  • [0028]
    FIG. 2 is an exploded view of keel 32 of articular component 12. As illustrated, the outer surface 42 of the keel 32 has been machined, preferably with a pulsing Nd:YV04 laser, to define a plurality of inverted frustoconical protrusions 44. As shown in the partial cross-sectional view of FIG. 3, the protrusions 44 define cavities 46 that, in one preferred example, can house bone growth promoting material, such as Infuse, or cellular material. The protrusions 44 taper inwardly to the body 48. As a result, the cavities 46 defined between protrusions 44 are configured to receive bone growth from an adjacent vertebral member and provide a bio-locking function. That is, the cavities 46, as defined by the protrusions 44, are wider at the body 48 than at the bone growth openings 50. Thus, bone may enter a cavity 48 via relatively narrow opening 50 and then fill out the cavity as bone growth continues. Protrusions 44 are shown as being uniformly sized, shaped, and spaced, however, it is contemplated that the protrusions can have varying sizes and shapes. The spacing between protrusions may also vary.
  • [0029]
    In the illustrated example, the protrusions are formed by machining the body 48. As shown, in this example, the protrusions are identically shaped, sized, and spaced. However, it is contemplated that the protrusions may be machined to be non-uniformly shaped, sized, and/or spaced. Moreover, while only a portion of the bone engaging interface of keel 32 is shown, it is recognized that other portions of the bone engaging interface may be differently constructed from that shown in FIG. 3. In this regard, a bone engaging surface may be machined to have multiple and different bone engaging interfaces. It is also recognized that some portions of the bone engaging surface may be machined whereas other portions are roughened using conventional roughening processes or left smooth. Additionally, it is contemplated that one of various machining techniques can be used for forming the protrusions on implant surfaces that are typically too delicate for surface roughening or relatively inaccessible by conventional surface roughening techniques.
  • [0030]
    Also, while only the bone engaging interface of a keel has been shown and described, it is understood that other bone engaging surfaces of the joint may be machined to form a bone engaging interface similar to that described herein.
  • [0031]
    FIGS. 4-8 illustrate other representative bone engaging interfaces that may be formed on a keel or other bone engaging surface of joint 10. It is recognized that the present disclosure is not limited to the representative bone engaging interfaces illustrated in FIGS. 4-8. Moreover, the bone engaging interface protrusions are not limited to the shapes, sizes, or orientations described herein.
  • [0032]
    FIG. 4 is a partial cross-sectional view of a bone engaging interface according to another example of the present disclosure. The bone engaging interface 52 has a body 54 with a number of pointed (cone-shaped) protrusions 56 extending therefrom. The pointed protrusions 56 are spaced from one another to define a number of cavities 58 that are configured to house bone growth promoting or cellular material. The protrusions are shown as being uniformly sized, shaped, and spaced, but it is contemplated that the protrusions can have varying sizes and shapes. The spacing between protrusions may also vary.
  • [0033]
    Referring now to FIG. 5, a partial cross-sectional view of a bone engaging interface according to another example of the present disclosure is shown. The bone engaging interface 60 differs from the bone engaging interfaces heretofore shown in that the height of protrusions 62 extending from body 64 varies. In the illustrated example, the protrusions 62, which are spaced from one another to define cavities 66, have a “stair-stepped” profile. Cavities 66 are designed to house bone growth promoting or cellular material.
  • [0034]
    As illustrated, the height of the protrusions 62 increases from left-to-right along the profile of the bone engaging interface 60. In one preferred example, the direction of descending protrusion height, as indicated by arrow A, coincides with the direction of implantation. That is, the bone engaging interface 60 is constructed such that end 64 represents the leading edge of the interface and end 66 represents the trailing edge of the interface. This configuration of the bone engaging interface 60 allows the implant to bite in or otherwise engage the adjacent vertebral member when being implanted. Additionally, when preparing the vertebral member for the keel, for example, a slight taper can be cut into the vertebral member that matches the taper provided by the bone engaging interface 60.
  • [0035]
    Bone engaging interface 60, as referenced above, is designed to scratch or otherwise bite into the vertebral member when implanted in the vertebral member. Specifically, the trailing walls 68 of protrusions 62 are angled to engage the vertebral member when the implant is inserted into the vertebral member. As a result, cellular material can be scraped from the vertebral member and into the cavities 66 during implantation. This cellular material can then help promote bone growth into the cavities 66. Further, the height and angle of the trailing walls 68 can be controlled during fabrication to provide a desired degree of bio-scraping. In other words, the amount of cellular material scraped from the vertebral member and deposited in cavities 66 can be controlled by precise formation of the bone engaging interface. The leading walls 70 of the bone engaging interface 60 bite into the vertebral member along a direction opposite the direction of implantation. In this regard, when loaded, the bone engaging interface is locked relatively in place.
  • [0036]
    In the example illustrated in FIG. 5, the height of the protrusions 62 decrease, or descend, in the direction of implantation. However, it is contemplated that the height of the protrusions could increase, or ascend, in the direction of implantation.
  • [0037]
    FIG. 6 is a cross-sectional view of another representative bone engaging interface according to the present disclosure. In this example, the bone engaging interface 72 has angled protrusions 74 extending from body 76 and defining cavities 78 that, in a preferred example, are configured to house bone growth promoting material or scaped or filed in cellular material. As illustrated, the protrusions 74 are angled in a direction opposite to the direction of implantation, referenced by arrow A. In this regard, bone engaging interface 72 is designed to slide, relatively easily, into the vertebral member without much degradation of the engaging surface of the vertebral member. However, as the protrusions 74 are angled in a direction opposite the direction of implantation, the bone engaging interface 72 is designed to bite into the vertebral member when the bone engaging interface 72 is withdrawn from or otherwise moved in a direction opposite the direction of implantation. Thus, in one preferred method of using an implant having a bone engaging interface similar to that shown in FIG. 6, a surgeon inserts the implant into position along a direction of implantation. To fix the implant into position, the surgeon then begins to withdraw the implant in a direction opposite the direction of implantation. The surgeon continues to withdraw the implant until the angular protrusions bite or cut into the vertebral member. It is recognized that the surgeon may need to slightly angle the implant to assist with the engagement of the bone engaging interface with the vertebral member. Similar to the bone engaging interfaces described above, cavities 78 preferably are deposited with bone growth promoting material, e.g., filed cellular material.
  • [0038]
    In the example illustrated in FIG. 7, the angled protrusions 74 are angled in a direction opposite to the direction of implantation. However, it is contemplated that the angles could favor, rather than oppose, the direction of implantation.
  • [0039]
    FIG. 7 is a perspective view of a portion of a bone engaging interface according to another example of the present disclosure. In this example, the bone engaging interface 80 has a series of complex-shaped protrusions 82 extending from body 84. Similar to that described above, the protrusions 82 are spaced from one another to define cavities 86 that preferably house bone growth promoting material and, as shown in FIG. 7, for example, the two-dimensional arrangement of the protrusions defines an in intricate network of cavities that are designed to receive bone growth thereby provide a bio-locking of the implant. Similar to the bone engaging interfaces described above, protrusions 82 are formed by laser machining. Unlike conventional etching techniques, formation of protrusions 82 can be precisely controlled to yield a desired shape, size, and spacing.
  • [0040]
    The bone engaging interfaces have been described above as being formed on a bone engaging surface of a keel or other member of an articulating prosthetic joint. The bone engaging interfaces have been described as having protrusions that, in one example, are angled to assist with implantation but also provide a bio-locking. In this regard, it is contemplated that the draft of the protrusions can be machined to provide a desired release-ability. That is, with more draft, it would be more difficult to release or remove the implant after bone ingrowth. On the other hand, with less draft, it would be easier for a surgeon to remove the implant after bone ingrowth and, such removal could be done without significant bone loss. Also, it is noted that in the example of FIG. 5 the protrusions are constructed such that the stair-stepped profile descends in the direction of implantation, and in the example of FIG. 6, the protrusions are angled in a direction opposite of the direction of implantation. However, it is contemplated that the protrusions may be constructed such that movement is resisted in directions other than in or opposite the direction of implantation. For example, the implant may be constructed such that the protrusions resist movement in a posterior or anterior direction when the implant is inserted along a lateral approach. Additionally, embodiments of the present disclosure have been described with respect to resisting migration or movement in only one direction; however, it is noted that the implant may be constructed to resist movement in more than direction.
  • [0041]
    Heretofore, the present disclosure has been described with respect to joint replacements. The present disclosure, however, is not so limited. The present disclosure can be implemented with other implantable devices, such as a bone screw. A representative bone screw is shown in FIG. 8.
  • [0042]
    Bone screw 88 includes a shaft 90 connected to a curvate head 92. Curvate head 92 has a centrally disposed notch 94 configured to receive the driving end of driving instrument. Bone screw 88 includes a series of threads 96 formed circumferentially around shaft 90. The screw is configured to sit within a rod-receiver coupler (not shown) designed to hold a stabilization rod. The shaft 90 of bone screw 88 includes, in the illustrate example, three engineered bone engaging interfaces 98. These areas of the shaft 90 are, in the illustrated example, disposed between adjacent threads 96 to define bone growth promoting areas along the bone screw. In the illustrated example, the bone engaging interfaces do not extend circumferentially around the shaft 90; however, it is contemplated that an engineering surface may be formed circumferentially around shaft 90.
  • [0043]
    FIG. 9 is an exploded view of one bone engaging interface 98. As shown, the bone engaging interface 98 is defined between a pair of adjacent threads 96 on the shaft 90 of the bone screw. For purposes of illustration and not limitation, the bone engaging interface is shown constructed similar to the bone engaging interface illustrated in FIGS. 2-3. That is, the bone engaging interface includes a plurality of inverse frustoconical protrusions 100 spaced from one another to define cavities (not numbered) that can be deposited with bone growth promoting material. The bone engaging interface 98 is shown as being formed on the shaft between adjacent threads 96. However, it is contemplated that the threads themselves may also be laser machined to have a bone engaging interface such as that described herein.
  • [0044]
    The present disclosure has been described with respect to a representative intervertebral prosthetic joint and a representative bone screw; however, the present disclosure is applicable with other implants not specifically described herein. For example, the present disclosure is also applicable with bone plates, cages, and artificial discs. The present disclosure is also applicable with knee, hip, and other anatomical implants in addition to the vertebral implants described herein.
  • [0045]
    As described herein, the bone engaging interfaces are preferably formed using laser machining. With laser machining the size, shape, orientation, position, depth, and pattern of the bone engaging interfaces can be controlled. In a preferred example, the cavities defined in the bone engaging interfaces have a depth of approximately 100 microns; however, the present disclosure is not so limited. Also, while laser machining has been identified as one technique for engineering the surfaces of an implant, it is recognized that other techniques, such as EDM, could be used for engineering the surfaces of an implant.
  • [0046]
    Although only a few exemplary embodiments have been described in detail above, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this disclosure. Accordingly, all such modifications and alternative are intended to be included within the scope of the invention as defined in the following claims. Those skilled in the art should also realize that such modifications and equivalent constructions or methods do not depart from the spirit and scope of the present disclosure, and that they may make various changes, substitutions, and alterations herein without departing from the spirit and scope of the present disclosure. It is understood that all spatial references, such as “horizontal,” “vertical,” “top,” “upper,” “lower,” “bottom,” “left,” “right,” “cephalad,” “caudal,” “upper,” and “lower,” are for illustrative purposes only and can be varied within the scope of the disclosure. Further, the embodiments of the present disclosure may be adapted to work singly or in combination over multiple spinal levels and vertebral motion segments. Also, though the embodiments have been described with respect to the spine and, more particularly, to vertebral motion segments, the present disclosure has similar application to other motion segments and parts of the body. In the claims, means-plus-function clauses are intended to cover the elements described herein as performing the recited function and not only structural equivalents, but also equivalent elements.

Claims (25)

1. An implant comprising:
a body; and
a bone engaging interface formed on a portion of the body and shaped to favor movement of the implant in a first direction and to resist movement in a second direction opposite the first direction.
2. The implant of claim 1 wherein the bone engaging interface includes a set of protrusions defining a plurality of bone ingrowth cavities.
3. The implant of claim 2 wherein the set of protrusions are angled in the second direction relative to the body.
4. The implant of claim 2 wherein the set of protrusions includes a first subset of protrusions and a second subset of protrusions, the first subset of protrusions extending from the body more than the second subset of protrusions.
5. The implant of claim 2 further comprising bone growing material in the plurality of bone ingrowth cavities.
6. The implant of claim 1 wherein the bone engaging interface is configured to resist movement in the second direction when a load is placed thereon.
7. The implant of claim 1 wherein the bone engaging interface is formed by laser machining the body.
8. A intervertebral prosthetic joint comprising:
a first articular component and a second articular component;
a first bone engaging surface defined on a portion of the first articulur component;
a second bone engaging surface defined on a portion of the second articulur component, and
wherein each bone engaging surface is configured to provide a migration promoting interface along a first direction and provide an anti-migratory interface along a second direction opposite the first direction.
9. The joint of claim 8 wherein each bone engaging surface includes a laser-machined set of protrusions defining a first plurality and a second plurality of bone ingrowth cavities.
10. The joint of claim 9 wherein at least a portion of the first plurality and the second plurality of bone ingrowth cavities contains bone growth promoting material.
11. An implant comprising:
an implant body having a bone engaging surface;
a plurality of cavities formed by machining a portion of the bone engaging surface of the implant body; and
bone growth material deposited in the plurality of cavities.
12. The implant of claim 11 further comprising a set of protrusions extending from the implant body and defining the plurality of cavities, the set of protrusions being directionally aligned at an angle relative to the implant body.
13. The implant of claim 12 wherein the set of protrusions provide a non-gripping interface when the implant body is translated along a first direction and provide a bone-gripping interface when the implant body is translated along a second direction opposite the first direction.
14. The implant of claim 12 wherein the set of protrusions includes a first subset of protrusions and a second subset of protrusions different in at least one of height, spacing, shape, and depth from the first subset of protrusions.
15. A surgical method for positioning an intervertebral implant, the method comprising:
preparing a disc space for reception of an intervertebral implant;
inserting the intervertebral implant, along a first direction, into the disc space;
commencing withdrawing the intervertebral implant from the disc space along a second direction opposite the first direction; and
terminating withdrawal of the intervertebral implant when the intervertebral implant engages a vertebral body defining the disc space.
16. A method of manufacturing an implant, the method comprising:
forming an implant body;
machining the implant body to define a plurality of protrusions and cavities; and
depositing bone growth promoting material in the cavities.
17. The method of claim 16 wherein the machining includes defining the protrusions to be angled in a direction of implantation.
18. The method of claim 16 wherein the defining includes forming the protrusions to provide a non-gripping face for when the intervertebral implant is inserted into a disc space and to provide a gripping face for when the intervertebral implant is withdrawn from the disc space.
19. The method of claim 16 wherein the machining includes defining a first set of protrusions to have a first height and a second set of protrusions to have a second height different from the first height.
20. The method of claim 16 wherein the machining includes laser machining.
21. The method of claim 16 wherein the machining includes EDM.
22. A bone screw comprising:
a shaft;
a plurality of threads formed on the shaft and spaced from one another; and
a bone ingrowth cavity formed in the shaft in a space between a pair of threads.
23. The bone screw of claim 22 wherein the bone ingrowth cavity is formed by laser-machining of the shaft.
24. The bone screw of claim 22 further comprising bone growth material deposited in the bone ingrowth cavity.
25. The bone screw of claim 22 wherein the bone ingrowth cavity is shaped to have an opening that is smaller in width than a maximum width of the bone ingrowth cavity.
US11615158 2006-12-22 2006-12-22 Bone implant having engineered surfaces Abandoned US20080154378A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11615158 US20080154378A1 (en) 2006-12-22 2006-12-22 Bone implant having engineered surfaces

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11615158 US20080154378A1 (en) 2006-12-22 2006-12-22 Bone implant having engineered surfaces

Publications (1)

Publication Number Publication Date
US20080154378A1 true true US20080154378A1 (en) 2008-06-26

Family

ID=39544045

Family Applications (1)

Application Number Title Priority Date Filing Date
US11615158 Abandoned US20080154378A1 (en) 2006-12-22 2006-12-22 Bone implant having engineered surfaces

Country Status (1)

Country Link
US (1) US20080154378A1 (en)

Cited By (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070142846A1 (en) * 2005-05-20 2007-06-21 Neotract, Inc. Integrated handle assembly for anchor delivery system
US20070198093A1 (en) * 2006-02-17 2007-08-23 Amedica Corporation Spinal implant with offset keels
US20080033458A1 (en) * 2005-05-20 2008-02-07 Neotract, Inc. Multi-actuating trigger anchor delivery system
US20080039893A1 (en) * 2005-05-20 2008-02-14 Neotract, Inc. Multi-actuating trigger anchor delivery system
US20080269893A1 (en) * 2007-04-25 2008-10-30 Jmea Corporation Prosthesis with a Selectively Applied Bone Growth Promoting Agent
US20080275555A1 (en) * 2007-05-01 2008-11-06 Exploramed Nc4, Inc. Extra-Articular Implantable Mechanical Energy Absorbing Systems
US20080275560A1 (en) * 2007-05-01 2008-11-06 Exploramed Nc4, Inc. Femoral and tibial base components
US20080275561A1 (en) * 2007-05-01 2008-11-06 Exploramed Nc4, Inc. Extra-articular implantable mechanical energy absorbing systems and implantation method
US20090048675A1 (en) * 2007-04-25 2009-02-19 Bhatnagar Mohit K Spinal Fusion Implants with Selectively Applied Bone Growth Promoting Agent
US20100042220A1 (en) * 2006-02-23 2010-02-18 Michael Tauber Bone fixation surfaces for intervertebral implants
WO2011023153A1 (en) * 2009-07-25 2011-03-03 Bernhard Hildebrandt Structuring of the bone contact surface of endoprostheses
US7951158B2 (en) 2005-05-20 2011-05-31 Neotract, Inc. Devices, systems and methods for retracting, lifting, compressing, supporting or repositioning tissues or anatomical structures
US20110208189A1 (en) * 2005-02-22 2011-08-25 Tecres S.P.A. Disposable device for treatment of infections of human limbs
US8007503B2 (en) 2005-05-20 2011-08-30 Neotract, Inc. Apparatus and method for manipulating or retracting tissue and anatomical structure
US8216254B2 (en) 2005-05-20 2012-07-10 Neotract, Inc. Anchor delivery system with replaceable cartridge
US8257395B2 (en) 2007-09-21 2012-09-04 Jmea Corporation Spinal fixation with selectively applied bone growth promoting agent
US8333776B2 (en) 2005-05-20 2012-12-18 Neotract, Inc. Anchor delivery system
US8343187B2 (en) 2005-05-20 2013-01-01 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US8394113B2 (en) 2005-05-20 2013-03-12 Neotract, Inc. Coiled anchor device
US8425535B2 (en) 2005-05-20 2013-04-23 Neotract, Inc. Multi-actuating trigger anchor delivery system
US8454655B2 (en) 2002-03-14 2013-06-04 Neotract, Inc. Method for anchoring suture and approximating tissue
US8491606B2 (en) 2005-05-20 2013-07-23 Neotract, Inc. Median lobe retraction apparatus and method
US8496710B2 (en) 2005-05-06 2013-07-30 Titan Spine, Llc Interbody spinal implant having a roughened surface topography
US8529584B2 (en) 2005-05-20 2013-09-10 Neotract, Inc. Median lobe band implant apparatus and method
US8551176B2 (en) 2005-05-06 2013-10-08 Titan Spine, Llc Spinal implant having a passage for enhancing contact between bone graft material and cortical endplate bone
US8562685B2 (en) 2005-05-06 2013-10-22 Titan Spine, Llc Spinal implant and integration plate for optimizing vertebral endplate contact load-bearing edges
US8562684B2 (en) 2005-05-06 2013-10-22 Titan Spine, Llc Endplate-preserving spinal implant with an integration plate having a roughened surface topography
US8585767B2 (en) 2005-05-06 2013-11-19 Titan Spine, Llc Endplate-preserving spinal implant with an integration plate having durable connectors
US8585765B2 (en) 2005-05-06 2013-11-19 Titan Spine, Llc Endplate-preserving spinal implant having a raised expulsion-resistant edge
US8585766B2 (en) 2005-05-06 2013-11-19 Titan Spine, Llc Endplate-preserving spinal implant with an integration plate having durable connectors
US8591590B2 (en) 2005-05-06 2013-11-26 Titan Spine, Llc Spinal implant having a transverse aperture
US8597362B2 (en) 2009-08-27 2013-12-03 Cotera, Inc. Method and apparatus for force redistribution in articular joints
US8603106B2 (en) 2005-05-20 2013-12-10 Neotract, Inc. Integrated handle assembly for anchor delivery system
US8617248B2 (en) 2005-05-06 2013-12-31 Titan Spine, Llc Spinal implant having variable ratios of the integration surface area to the axial passage area
US8628542B2 (en) 2005-05-20 2014-01-14 Neotract, Inc. Median lobe destruction apparatus and method
US8668705B2 (en) 2005-05-20 2014-03-11 Neotract, Inc. Latching anchor device
US8758442B2 (en) 2005-05-06 2014-06-24 Titan Spine, Llc Composite implants having integration surfaces composed of a regular repeating pattern
US8758443B2 (en) 2005-05-06 2014-06-24 Titan Spine, Llc Implants with integration surfaces having regular repeating surface patterns
US8758366B2 (en) 2007-07-09 2014-06-24 Neotract, Inc. Multi-actuating trigger anchor delivery system
US8814939B2 (en) 2005-05-06 2014-08-26 Titan Spine, Llc Implants having three distinct surfaces
US8834492B2 (en) 2005-05-20 2014-09-16 Neotract, Inc. Continuous indentation lateral lobe apparatus and method
US8845724B2 (en) 2009-08-27 2014-09-30 Cotera, Inc. Method and apparatus for altering biomechanics of the articular joints
US8894714B2 (en) 2007-05-01 2014-11-25 Moximed, Inc. Unlinked implantable knee unloading device
US8979934B2 (en) * 2010-07-20 2015-03-17 X-Spine Systems, Inc. Composite orthopedic implant having a low friction material substrate with primary frictional features and secondary frictional features
US8992622B2 (en) 2005-05-06 2015-03-31 Titan Spine, Llc Interbody spinal implant having a roughened surface topography
US8992619B2 (en) * 2011-11-01 2015-03-31 Titan Spine, Llc Microstructured implant surfaces
US9034001B2 (en) 2005-05-20 2015-05-19 Neotract, Inc. Slotted anchor device
US9044270B2 (en) 2011-03-29 2015-06-02 Moximed, Inc. Apparatus for controlling a load on a hip joint
US9125756B2 (en) 2005-05-06 2015-09-08 Titan Spine, Llc Processes for producing regular repeating patterns on surfaces of interbody devices
US9149266B2 (en) 2005-05-20 2015-10-06 Neotract, Inc. Deforming anchor device
US9161749B2 (en) 2011-04-14 2015-10-20 Neotract, Inc. Method and apparatus for treating sexual dysfunction
US9168147B2 (en) 2005-05-06 2015-10-27 Titan Spine, Llc Self-deploying locking screw retention device
US9364212B2 (en) 2005-05-20 2016-06-14 Neotract, Inc. Suture anchoring devices and methods for use
US9398957B2 (en) 2007-05-01 2016-07-26 Moximed, Inc. Femoral and tibial bases
US9468466B1 (en) 2012-08-24 2016-10-18 Cotera, Inc. Method and apparatus for altering biomechanics of the spine
US9498349B2 (en) 2012-10-09 2016-11-22 Titan Spine, Llc Expandable spinal implant with expansion wedge and anchor
US9504461B2 (en) 2005-05-20 2016-11-29 Neotract, Inc. Anchor delivery system
US9549739B2 (en) 2005-05-20 2017-01-24 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US9615935B2 (en) 2014-01-30 2017-04-11 Titan Spine, Llc Thermally activated shape memory spring assemblies for implant expansion
US9642721B2 (en) 2012-10-02 2017-05-09 Titan Spine, Llc Implants with self-deploying anchors
US9668868B2 (en) 2009-08-27 2017-06-06 Cotera, Inc. Apparatus and methods for treatment of patellofemoral conditions
US9848995B2 (en) 2012-03-20 2017-12-26 Titan Spine Llc Process for fabricating bioactive vertebral endplate bone-contacting surfaces on a spinal implant
US9861408B2 (en) 2009-08-27 2018-01-09 The Foundry, Llc Method and apparatus for treating canine cruciate ligament disease

Citations (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865603A (en) * 1988-02-04 1989-09-12 Joint Medical Products Corporation Metallic prosthetic devices having micro-textured outer surfaces
US4965430A (en) * 1989-09-18 1990-10-23 Dow Corning Wright Corp. Method of laser machining molds with microtextured surfaces
US5246530A (en) * 1990-04-20 1993-09-21 Dynamet Incorporated Method of producing porous metal surface
US5607607A (en) * 1993-11-01 1997-03-04 Naiman; Charles S. System and assemblage for producing microtexturized substratesand implants
US5716412A (en) * 1996-09-30 1998-02-10 Johnson & Johnson Professional, Inc. Implantable article with ablated surface
US6005164A (en) * 1993-10-01 1999-12-21 Lucocer Aktiebolag Implant with porous surface
US6160240A (en) * 1997-10-14 2000-12-12 Biotronik Mess-und Therapiegerate GmbH & Co Ingenieurburo Berlin Method of producing microstructural medical implants
US20010016773A1 (en) * 1998-10-15 2001-08-23 Hassan Serhan Spinal disc
US20010039454A1 (en) * 1993-11-02 2001-11-08 John Ricci Orthopedic implants having ordered microgeometric surface patterns
US20020049497A1 (en) * 2000-10-11 2002-04-25 Mason Michael D. Graftless spinal fusion device
US6402785B1 (en) * 1999-06-04 2002-06-11 Sdgi Holdings, Inc. Artificial disc implant
US20020133232A1 (en) * 1993-11-02 2002-09-19 Ricci John L. Microstructured dual sided membrane for tissue growth and regeneration
US6454773B1 (en) * 1996-11-07 2002-09-24 Sdgi Holdings, Inc. Multi-angle bone screw assembly using shape-memory technology
US20030065401A1 (en) * 2001-01-25 2003-04-03 Mark Amrich Textured surface having undercut micro recesses in a surface
US6599322B1 (en) * 2001-01-25 2003-07-29 Tecomet, Inc. Method for producing undercut micro recesses in a surface, a surgical implant made thereby, and method for fixing an implant to bone
US6620196B1 (en) * 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US20030208273A1 (en) * 2002-01-09 2003-11-06 Lukas Eisermann Intervertebral prosthetic joint
US20040000540A1 (en) * 2002-05-23 2004-01-01 Soboyejo Winston O. Laser texturing of surfaces for biomedical implants
US20040158328A1 (en) * 2003-02-12 2004-08-12 Sdgi Holdings, Inc. Mobile bearing articulating disc
US20040224179A1 (en) * 2003-05-09 2004-11-11 Lsp Technologies, Inc. Laser peening method and apparatus using tailored laser beam spot sizes
US20050075734A1 (en) * 2003-10-07 2005-04-07 Michael Fulton Spinal implant
US20050119750A1 (en) * 2002-04-04 2005-06-02 Marthys Medizinaltechnik Ag Intervertebral prosthesis or nucleus replacement prosthesis
US20050119758A1 (en) * 2003-07-30 2005-06-02 Bio-Lok International Inc. Surgical implant for promotion of osseo-integration
US20050143820A1 (en) * 2003-12-02 2005-06-30 St. Francis Medical Technologies, Inc. Method of laterally inserting an artificial vertebral disk replacement implant with translating pivot point
US20050159818A1 (en) * 2002-06-26 2005-07-21 Jason Blain Total disc replacement system and related methods
US20050182494A1 (en) * 2004-02-17 2005-08-18 Schmid Steven R. Textured surfaces for orthopedic implants
US20050203626A1 (en) * 2004-03-15 2005-09-15 Sdgi Holdings, Inc. System and method for stabilizing a prosthetic device
US20050211680A1 (en) * 2003-05-23 2005-09-29 Mingwei Li Systems and methods for laser texturing of surfaces of a substrate
US20060036325A1 (en) * 2003-07-31 2006-02-16 Globus Medical Inc. Anterior prosthetic spinal disc replacement
US20060041314A1 (en) * 2004-08-20 2006-02-23 Thierry Millard Artificial disc prosthesis
US20060178744A1 (en) * 2005-02-04 2006-08-10 Spinalmotion, Inc. Intervertebral prosthetic disc with shock absorption
US20070053378A1 (en) * 2005-09-06 2007-03-08 Kuekes Philip J Constant-weight-code-based addressing of nanoscale and mixed microscale/nanoscale arrays
US20070073404A1 (en) * 2005-09-23 2007-03-29 Ralph Rashbaum Intervertebral disc prosthesis
US20070173941A1 (en) * 2006-01-25 2007-07-26 Sdgi Holdings, Inc. Intervertebral prosthetic disc and method of installing same
US20070225811A1 (en) * 2006-03-22 2007-09-27 Sdgi Holdings, Inc. Conformable orthopedic implant
US20070260317A1 (en) * 2003-07-31 2007-11-08 Ankney David W Transforaminal prosthetic spinal disc replacement
US20070265707A1 (en) * 1999-07-02 2007-11-15 Thierry Marnay Intervertebral implant
US20080051901A1 (en) * 2006-07-28 2008-02-28 Spinalmotion, Inc. Spinal Prosthesis with Multiple Pillar Anchors
US20080051900A1 (en) * 2006-07-28 2008-02-28 Spinalmotion, Inc. Spinal Prosthesis with Offset Anchors
US20080077243A1 (en) * 2006-09-26 2008-03-27 Lee Casey K Intervertebral prosthesis endplate having double dome and surgical tools for implanting same
US20080161923A1 (en) * 2006-09-28 2008-07-03 Matthew Parsons Intervertebral Motion Disc Having A Resorbable Keel
US7485145B2 (en) * 2004-02-23 2009-02-03 Alphatec Spine, Incorporated Artificial intervertebral disc assembly

Patent Citations (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865603A (en) * 1988-02-04 1989-09-12 Joint Medical Products Corporation Metallic prosthetic devices having micro-textured outer surfaces
US4965430A (en) * 1989-09-18 1990-10-23 Dow Corning Wright Corp. Method of laser machining molds with microtextured surfaces
US5246530A (en) * 1990-04-20 1993-09-21 Dynamet Incorporated Method of producing porous metal surface
US6005164A (en) * 1993-10-01 1999-12-21 Lucocer Aktiebolag Implant with porous surface
US5607607A (en) * 1993-11-01 1997-03-04 Naiman; Charles S. System and assemblage for producing microtexturized substratesand implants
US5645740A (en) * 1993-11-01 1997-07-08 Naiman; Charles S. System and assemblage for producing microtexturized substrates and implants
US20020133232A1 (en) * 1993-11-02 2002-09-19 Ricci John L. Microstructured dual sided membrane for tissue growth and regeneration
US20010039454A1 (en) * 1993-11-02 2001-11-08 John Ricci Orthopedic implants having ordered microgeometric surface patterns
US5716412A (en) * 1996-09-30 1998-02-10 Johnson & Johnson Professional, Inc. Implantable article with ablated surface
US6454773B1 (en) * 1996-11-07 2002-09-24 Sdgi Holdings, Inc. Multi-angle bone screw assembly using shape-memory technology
US6160240A (en) * 1997-10-14 2000-12-12 Biotronik Mess-und Therapiegerate GmbH & Co Ingenieurburo Berlin Method of producing microstructural medical implants
US20010016773A1 (en) * 1998-10-15 2001-08-23 Hassan Serhan Spinal disc
US6402785B1 (en) * 1999-06-04 2002-06-11 Sdgi Holdings, Inc. Artificial disc implant
US20070265707A1 (en) * 1999-07-02 2007-11-15 Thierry Marnay Intervertebral implant
US6620196B1 (en) * 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US20020049497A1 (en) * 2000-10-11 2002-04-25 Mason Michael D. Graftless spinal fusion device
US20040186578A1 (en) * 2000-10-11 2004-09-23 Mason Michael D. Method for graftless spinal fusion
US6599322B1 (en) * 2001-01-25 2003-07-29 Tecomet, Inc. Method for producing undercut micro recesses in a surface, a surgical implant made thereby, and method for fixing an implant to bone
US20030194869A1 (en) * 2001-01-25 2003-10-16 Amrich Mark P. Method for producing undercut micro recesses in a surface, a surgical implant made thereby, and method for fixing an implant to bone
US20030065401A1 (en) * 2001-01-25 2003-04-03 Mark Amrich Textured surface having undercut micro recesses in a surface
US7018418B2 (en) * 2001-01-25 2006-03-28 Tecomet, Inc. Textured surface having undercut micro recesses in a surface
US6740118B2 (en) * 2002-01-09 2004-05-25 Sdgi Holdings, Inc. Intervertebral prosthetic joint
US20030208273A1 (en) * 2002-01-09 2003-11-06 Lukas Eisermann Intervertebral prosthetic joint
US20060095133A1 (en) * 2002-01-09 2006-05-04 Lukas Eisermann Intervertebral prosthetic joint
US20050119750A1 (en) * 2002-04-04 2005-06-02 Marthys Medizinaltechnik Ag Intervertebral prosthesis or nucleus replacement prosthesis
US20040000540A1 (en) * 2002-05-23 2004-01-01 Soboyejo Winston O. Laser texturing of surfaces for biomedical implants
US20050159818A1 (en) * 2002-06-26 2005-07-21 Jason Blain Total disc replacement system and related methods
US20040220668A1 (en) * 2003-02-12 2004-11-04 Sdgi Holdings, Inc. Method and device for correcting spondylolisthesis from the lateral approach
US20040158328A1 (en) * 2003-02-12 2004-08-12 Sdgi Holdings, Inc. Mobile bearing articulating disc
US20050043802A1 (en) * 2003-02-12 2005-02-24 Sdgi Holdings, Inc. Articular disc prosthesis for lateral insertion
US20040224179A1 (en) * 2003-05-09 2004-11-11 Lsp Technologies, Inc. Laser peening method and apparatus using tailored laser beam spot sizes
US20050211680A1 (en) * 2003-05-23 2005-09-29 Mingwei Li Systems and methods for laser texturing of surfaces of a substrate
US20050119758A1 (en) * 2003-07-30 2005-06-02 Bio-Lok International Inc. Surgical implant for promotion of osseo-integration
US20060036325A1 (en) * 2003-07-31 2006-02-16 Globus Medical Inc. Anterior prosthetic spinal disc replacement
US20070260317A1 (en) * 2003-07-31 2007-11-08 Ankney David W Transforaminal prosthetic spinal disc replacement
US20050075734A1 (en) * 2003-10-07 2005-04-07 Michael Fulton Spinal implant
US20050143820A1 (en) * 2003-12-02 2005-06-30 St. Francis Medical Technologies, Inc. Method of laterally inserting an artificial vertebral disk replacement implant with translating pivot point
US20050182494A1 (en) * 2004-02-17 2005-08-18 Schmid Steven R. Textured surfaces for orthopedic implants
US7485145B2 (en) * 2004-02-23 2009-02-03 Alphatec Spine, Incorporated Artificial intervertebral disc assembly
US20050203626A1 (en) * 2004-03-15 2005-09-15 Sdgi Holdings, Inc. System and method for stabilizing a prosthetic device
US20060041314A1 (en) * 2004-08-20 2006-02-23 Thierry Millard Artificial disc prosthesis
US20060178744A1 (en) * 2005-02-04 2006-08-10 Spinalmotion, Inc. Intervertebral prosthetic disc with shock absorption
US20070053378A1 (en) * 2005-09-06 2007-03-08 Kuekes Philip J Constant-weight-code-based addressing of nanoscale and mixed microscale/nanoscale arrays
US20070073404A1 (en) * 2005-09-23 2007-03-29 Ralph Rashbaum Intervertebral disc prosthesis
US20070173941A1 (en) * 2006-01-25 2007-07-26 Sdgi Holdings, Inc. Intervertebral prosthetic disc and method of installing same
US20070225811A1 (en) * 2006-03-22 2007-09-27 Sdgi Holdings, Inc. Conformable orthopedic implant
US20080051901A1 (en) * 2006-07-28 2008-02-28 Spinalmotion, Inc. Spinal Prosthesis with Multiple Pillar Anchors
US20080051900A1 (en) * 2006-07-28 2008-02-28 Spinalmotion, Inc. Spinal Prosthesis with Offset Anchors
US20080077243A1 (en) * 2006-09-26 2008-03-27 Lee Casey K Intervertebral prosthesis endplate having double dome and surgical tools for implanting same
US20080161923A1 (en) * 2006-09-28 2008-07-03 Matthew Parsons Intervertebral Motion Disc Having A Resorbable Keel

Cited By (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8777992B2 (en) 2002-03-14 2014-07-15 Neotract, Inc. Methods for anchoring suture and approximating tissue
US8454655B2 (en) 2002-03-14 2013-06-04 Neotract, Inc. Method for anchoring suture and approximating tissue
US9452001B2 (en) * 2005-02-22 2016-09-27 Tecres S.P.A. Disposable device for treatment of infections of human limbs
US20110208189A1 (en) * 2005-02-22 2011-08-25 Tecres S.P.A. Disposable device for treatment of infections of human limbs
US8585766B2 (en) 2005-05-06 2013-11-19 Titan Spine, Llc Endplate-preserving spinal implant with an integration plate having durable connectors
US8617248B2 (en) 2005-05-06 2013-12-31 Titan Spine, Llc Spinal implant having variable ratios of the integration surface area to the axial passage area
US8591590B2 (en) 2005-05-06 2013-11-26 Titan Spine, Llc Spinal implant having a transverse aperture
US8814939B2 (en) 2005-05-06 2014-08-26 Titan Spine, Llc Implants having three distinct surfaces
US9125756B2 (en) 2005-05-06 2015-09-08 Titan Spine, Llc Processes for producing regular repeating patterns on surfaces of interbody devices
US8758442B2 (en) 2005-05-06 2014-06-24 Titan Spine, Llc Composite implants having integration surfaces composed of a regular repeating pattern
US9433511B2 (en) 2005-05-06 2016-09-06 Titan Spine, Llc Interbody spinal implant having a roughened surface topography
US8758443B2 (en) 2005-05-06 2014-06-24 Titan Spine, Llc Implants with integration surfaces having regular repeating surface patterns
US8585765B2 (en) 2005-05-06 2013-11-19 Titan Spine, Llc Endplate-preserving spinal implant having a raised expulsion-resistant edge
US8585767B2 (en) 2005-05-06 2013-11-19 Titan Spine, Llc Endplate-preserving spinal implant with an integration plate having durable connectors
US8562684B2 (en) 2005-05-06 2013-10-22 Titan Spine, Llc Endplate-preserving spinal implant with an integration plate having a roughened surface topography
US9168147B2 (en) 2005-05-06 2015-10-27 Titan Spine, Llc Self-deploying locking screw retention device
US8562685B2 (en) 2005-05-06 2013-10-22 Titan Spine, Llc Spinal implant and integration plate for optimizing vertebral endplate contact load-bearing edges
US8551176B2 (en) 2005-05-06 2013-10-08 Titan Spine, Llc Spinal implant having a passage for enhancing contact between bone graft material and cortical endplate bone
US8940053B2 (en) 2005-05-06 2015-01-27 Titan Spine, Llc Spinal implant and integration plate for optimizing vertebral endplate contact load-bearing edges
US8992622B2 (en) 2005-05-06 2015-03-31 Titan Spine, Llc Interbody spinal implant having a roughened surface topography
US8834571B2 (en) 2005-05-06 2014-09-16 Titan Spine, Llc Interbody spinal implant having a roughened surface topography
US8496710B2 (en) 2005-05-06 2013-07-30 Titan Spine, Llc Interbody spinal implant having a roughened surface topography
US9486203B2 (en) 2005-05-20 2016-11-08 Neotract, Inc. Latching anchor device
US7951158B2 (en) 2005-05-20 2011-05-31 Neotract, Inc. Devices, systems and methods for retracting, lifting, compressing, supporting or repositioning tissues or anatomical structures
US7909836B2 (en) 2005-05-20 2011-03-22 Neotract, Inc. Multi-actuating trigger anchor delivery system
US8043309B2 (en) 2005-05-20 2011-10-25 Neotract, Inc. Devices, systems and methods for retracting, lifting, compressing, supporting or repositioning tissues or anatomical structures
US8945152B2 (en) 2005-05-20 2015-02-03 Neotract, Inc. Multi-actuating trigger anchor delivery system
US8211118B2 (en) 2005-05-20 2012-07-03 Neotract, Inc. Apparatus and method for manipulating or retracting tissue and anatomical structure
US8216254B2 (en) 2005-05-20 2012-07-10 Neotract, Inc. Anchor delivery system with replaceable cartridge
US8939996B2 (en) 2005-05-20 2015-01-27 Neotract, Inc. Anchor delivery System
US8940001B2 (en) 2005-05-20 2015-01-27 Neotract, Inc. Devices, systems and methods for retracting, lifting, compressing, supporting or repositioning tissues or anatomical structures
US8007503B2 (en) 2005-05-20 2011-08-30 Neotract, Inc. Apparatus and method for manipulating or retracting tissue and anatomical structure
US8343187B2 (en) 2005-05-20 2013-01-01 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US8394113B2 (en) 2005-05-20 2013-03-12 Neotract, Inc. Coiled anchor device
US8394110B2 (en) 2005-05-20 2013-03-12 Neotract, Inc. Apparatus and method for manipulating or retracting tissue and anatomical structure
US8425535B2 (en) 2005-05-20 2013-04-23 Neotract, Inc. Multi-actuating trigger anchor delivery system
US7905889B2 (en) 2005-05-20 2011-03-15 Neotract, Inc. Integrated handle assembly for anchor delivery system
US8491606B2 (en) 2005-05-20 2013-07-23 Neotract, Inc. Median lobe retraction apparatus and method
US8333776B2 (en) 2005-05-20 2012-12-18 Neotract, Inc. Anchor delivery system
US7766923B2 (en) 2005-05-20 2010-08-03 Neotract, Inc. Integrated handle assembly for anchor delivery system
US8529584B2 (en) 2005-05-20 2013-09-10 Neotract, Inc. Median lobe band implant apparatus and method
US9034001B2 (en) 2005-05-20 2015-05-19 Neotract, Inc. Slotted anchor device
US9149266B2 (en) 2005-05-20 2015-10-06 Neotract, Inc. Deforming anchor device
US9320511B2 (en) 2005-05-20 2016-04-26 Neotract, Inc. Multi-actuating trigger anchor delivery system
US20070142846A1 (en) * 2005-05-20 2007-06-21 Neotract, Inc. Integrated handle assembly for anchor delivery system
US9364212B2 (en) 2005-05-20 2016-06-14 Neotract, Inc. Suture anchoring devices and methods for use
US9402711B2 (en) 2005-05-20 2016-08-02 Neotract, Inc. Median lobe band implant apparatus and method
US9504461B2 (en) 2005-05-20 2016-11-29 Neotract, Inc. Anchor delivery system
US8936609B2 (en) 2005-05-20 2015-01-20 Neotract, Inc. Apparatus and method for manipulating or retracting tissue and anatomical structure
US8603106B2 (en) 2005-05-20 2013-12-10 Neotract, Inc. Integrated handle assembly for anchor delivery system
US20080039893A1 (en) * 2005-05-20 2008-02-14 Neotract, Inc. Multi-actuating trigger anchor delivery system
US8628542B2 (en) 2005-05-20 2014-01-14 Neotract, Inc. Median lobe destruction apparatus and method
US8663243B2 (en) 2005-05-20 2014-03-04 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US8668705B2 (en) 2005-05-20 2014-03-11 Neotract, Inc. Latching anchor device
US8900252B2 (en) 2005-05-20 2014-12-02 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US8715298B2 (en) 2005-05-20 2014-05-06 Neotract, Inc. Apparatus and method for manipulating or retracting tissue and anatomical structure
US8888799B2 (en) 2005-05-20 2014-11-18 Neotract, Inc. Coiled anchor device
US8734468B2 (en) 2005-05-20 2014-05-27 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US20080033458A1 (en) * 2005-05-20 2008-02-07 Neotract, Inc. Multi-actuating trigger anchor delivery system
US20080033456A1 (en) * 2005-05-20 2008-02-07 Neotract, Inc. Integrated handle assembly for anchor delivery system
US20070276412A1 (en) * 2005-05-20 2007-11-29 Neotract, Inc. Integrated handle assembly for anchor delivery system
US9549739B2 (en) 2005-05-20 2017-01-24 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US8834492B2 (en) 2005-05-20 2014-09-16 Neotract, Inc. Continuous indentation lateral lobe apparatus and method
US8157815B2 (en) 2005-05-20 2012-04-17 Neotract, Inc. Integrated handle assembly for anchor delivery system
US20070198093A1 (en) * 2006-02-17 2007-08-23 Amedica Corporation Spinal implant with offset keels
US20100042220A1 (en) * 2006-02-23 2010-02-18 Michael Tauber Bone fixation surfaces for intervertebral implants
US8518119B2 (en) * 2006-02-23 2013-08-27 Faneuil Innovation Investments Ltd. Bone fixation surfaces for intervertebral implants
US20090048675A1 (en) * 2007-04-25 2009-02-19 Bhatnagar Mohit K Spinal Fusion Implants with Selectively Applied Bone Growth Promoting Agent
US20080269893A1 (en) * 2007-04-25 2008-10-30 Jmea Corporation Prosthesis with a Selectively Applied Bone Growth Promoting Agent
US8241357B2 (en) 2007-04-25 2012-08-14 Jmea Corporation Prosthesis with a selectively applied bone growth promoting agent
US8679166B2 (en) 2007-04-25 2014-03-25 Jmea Corporation Prosthesis with a selectively applied bone growth promoting agent
US20080275555A1 (en) * 2007-05-01 2008-11-06 Exploramed Nc4, Inc. Extra-Articular Implantable Mechanical Energy Absorbing Systems
US9655648B2 (en) 2007-05-01 2017-05-23 Moximed, Inc. Femoral and tibial base components
US8894714B2 (en) 2007-05-01 2014-11-25 Moximed, Inc. Unlinked implantable knee unloading device
US7655041B2 (en) 2007-05-01 2010-02-02 Moximed, Inc. Extra-articular implantable mechanical energy absorbing systems and implantation method
US9700419B2 (en) 2007-05-01 2017-07-11 Moximed, Inc. Extra-articular implantable mechanical energy absorbing systems and implantation method
US20080275567A1 (en) * 2007-05-01 2008-11-06 Exploramed Nc4, Inc. Extra-Articular Implantable Mechanical Energy Absorbing Systems
US20080275560A1 (en) * 2007-05-01 2008-11-06 Exploramed Nc4, Inc. Femoral and tibial base components
US9005298B2 (en) 2007-05-01 2015-04-14 Moximed, Inc. Extra-articular implantable mechanical energy absorbing systems
US20100121457A1 (en) * 2007-05-01 2010-05-13 Moximed, Inc. Extra-articular implantable mechanical energy absorbing systems and implantation method
US20080275561A1 (en) * 2007-05-01 2008-11-06 Exploramed Nc4, Inc. Extra-articular implantable mechanical energy absorbing systems and implantation method
US20080275558A1 (en) * 2007-05-01 2008-11-06 Exploramed Nc4, Inc. Extra-articular implantable mechanical energy absorbing systems and implantation method
US7678147B2 (en) 2007-05-01 2010-03-16 Moximed, Inc. Extra-articular implantable mechanical energy absorbing systems and implantation method
US9814579B2 (en) 2007-05-01 2017-11-14 Moximed, Inc. Unlinked implantable knee unloading device
US9125746B2 (en) 2007-05-01 2015-09-08 Moximed, Inc. Methods of implanting extra-articular implantable mechanical energy absorbing systems
US20100106247A1 (en) * 2007-05-01 2010-04-29 Moximed, Inc. Extra-Articular Implantable Mechanical Energy Absorbing Systems
US9398957B2 (en) 2007-05-01 2016-07-26 Moximed, Inc. Femoral and tibial bases
US8801795B2 (en) 2007-05-01 2014-08-12 Moximed, Inc. Extra-articular implantable mechanical energy absorbing systems
US8758366B2 (en) 2007-07-09 2014-06-24 Neotract, Inc. Multi-actuating trigger anchor delivery system
US8734487B2 (en) 2007-09-21 2014-05-27 Jmea Corporation Spinal fixation with selectively applied bone growth promoting agent
US8257395B2 (en) 2007-09-21 2012-09-04 Jmea Corporation Spinal fixation with selectively applied bone growth promoting agent
WO2011023153A1 (en) * 2009-07-25 2011-03-03 Bernhard Hildebrandt Structuring of the bone contact surface of endoprostheses
US9861408B2 (en) 2009-08-27 2018-01-09 The Foundry, Llc Method and apparatus for treating canine cruciate ligament disease
US8845724B2 (en) 2009-08-27 2014-09-30 Cotera, Inc. Method and apparatus for altering biomechanics of the articular joints
US9114016B2 (en) 2009-08-27 2015-08-25 Cotera, Inc. Method and apparatus for altering biomechanics of the articular joints
US8597362B2 (en) 2009-08-27 2013-12-03 Cotera, Inc. Method and apparatus for force redistribution in articular joints
US9795410B2 (en) 2009-08-27 2017-10-24 Cotera, Inc. Method and apparatus for force redistribution in articular joints
US9278004B2 (en) 2009-08-27 2016-03-08 Cotera, Inc. Method and apparatus for altering biomechanics of the articular joints
US9668868B2 (en) 2009-08-27 2017-06-06 Cotera, Inc. Apparatus and methods for treatment of patellofemoral conditions
US20150157465A1 (en) * 2010-07-20 2015-06-11 X-Spine Systems, Inc. Composite orthopedic implant having a low friction material substrate with primary frictional features and secondary frictional features
US8979934B2 (en) * 2010-07-20 2015-03-17 X-Spine Systems, Inc. Composite orthopedic implant having a low friction material substrate with primary frictional features and secondary frictional features
US9044270B2 (en) 2011-03-29 2015-06-02 Moximed, Inc. Apparatus for controlling a load on a hip joint
US9161749B2 (en) 2011-04-14 2015-10-20 Neotract, Inc. Method and apparatus for treating sexual dysfunction
US9314337B2 (en) 2011-11-01 2016-04-19 Titan Spine, Llc Microstructured implant surfaces
US8992619B2 (en) * 2011-11-01 2015-03-31 Titan Spine, Llc Microstructured implant surfaces
US9848995B2 (en) 2012-03-20 2017-12-26 Titan Spine Llc Process for fabricating bioactive vertebral endplate bone-contacting surfaces on a spinal implant
US9468466B1 (en) 2012-08-24 2016-10-18 Cotera, Inc. Method and apparatus for altering biomechanics of the spine
US9642721B2 (en) 2012-10-02 2017-05-09 Titan Spine, Llc Implants with self-deploying anchors
US9498349B2 (en) 2012-10-09 2016-11-22 Titan Spine, Llc Expandable spinal implant with expansion wedge and anchor
US9615935B2 (en) 2014-01-30 2017-04-11 Titan Spine, Llc Thermally activated shape memory spring assemblies for implant expansion

Similar Documents

Publication Publication Date Title
US7226482B2 (en) Multipiece allograft implant
US7226480B2 (en) Disc prosthesis
US7850736B2 (en) Vertebral fusion implants and methods of use
US6989031B2 (en) Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite
US6719796B2 (en) Spinal surgical prosthesis
US7025787B2 (en) Implantable joint prosthesis and associated instrumentation
US7326251B2 (en) Interbody fusion device
US6899735B2 (en) Modular intervertebral prosthesis system
US6143033A (en) Allogenic intervertebral implant
US8262737B2 (en) Composite interbody spinal implant having openings of predetermined size and shape
US20040068320A1 (en) Prosthetic disc and vertebral body replacement device having pyrolytic carbon bearing members
US20070255410A1 (en) Centrally driven expandable implant and method
US20070270957A1 (en) Vertebral implants having predetermined angular correction and methods of use
US20070255408A1 (en) Stabilized, adjustable expandable implant and method
US20070255409A1 (en) Expandable implant, instrument, and method
US20060265065A1 (en) Anterior interbody spinal implant
US5306307A (en) Spinal disk implant
US8551173B2 (en) Expandable intervertebral implant and associated method of manufacturing the same
EP0307241B1 (en) Surgical prosthetic implant
US20020147499A1 (en) Locking systems for implants
US20010016775A1 (en) Intervertebral implant
US20020026242A1 (en) Ramp-shaped intervertebral implant
US20080103601A1 (en) Corpectomy vertebral body replacement implant system
US8425607B2 (en) Anchor member locking features
US20080243251A1 (en) Intervertebral Device Having Expandable Endplates

Legal Events

Date Code Title Description
AS Assignment

Owner name: WARSAW ORTHOPEDIC, INC., INDIANA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PELO, MARK J.;REEL/FRAME:018698/0714

Effective date: 20061222