US20080025927A1 - Delivery system for an oral care substance - Google Patents

Delivery system for an oral care substance Download PDF

Info

Publication number
US20080025927A1
US20080025927A1 US11888147 US88814707A US2008025927A1 US 20080025927 A1 US20080025927 A1 US 20080025927A1 US 11888147 US11888147 US 11888147 US 88814707 A US88814707 A US 88814707A US 2008025927 A1 US2008025927 A1 US 2008025927A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
oral
material
care
strip
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11888147
Inventor
Paul Sagel
Robert Dirksing
Frederick Rohman
Original Assignee
Sagel Paul A
Dirksing Robert S
Rohman Frederick J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/02Cosmetics or similar toilet preparations characterised by special physical form
    • A61K8/0208Tissues; Wipes; Patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/40Peroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/02Cosmetics or similar toilet preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/19Cosmetics or similar toilet preparations characterised by the composition containing inorganic ingredients
    • A61K8/22Peroxides; Oxygen; Ozone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8111Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063Periodont
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26Optical properties
    • A61K2800/262Transparent; Translucent

Abstract

A tooth whitening substance formed into a thin layer is provided. The tooth whitening substance includes a polyox resin and a tooth whitening active. The polyox resin adheres the thin layer to a plurality of teeth for a sufficient time to allow the tooth whitening active to act upon the plurality of teeth.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • [0001]
    This application is a continuation of U.S. application Ser. No. 11/824,056, filed Jun. 29, 2007, which is a continuation of U.S. application Ser. No. 11/638,844, filed Dec. 14, 2006, which is a continuation of U.S. application Ser. No. 11/157,769, filed Jun. 21, 2005, which is a continuation of U.S. application Ser. No. 10/410,037 filed Apr. 9, 2003 (abandoned), which is a continuation of U.S. application Ser. No. 09/681,729, filed May 29, 2001, now U.S. Pat. No. 6,551,579, which is a continuation of U.S. application Ser. No. 09/605,220 filed on Jun. 28, 2000, which is a continuation of U.S. application Ser. No. 09/196,364, filed on Nov. 19, 1998, now U.S. Pat. No. 6,096,328 which is a continuation-in-part of U.S. application Ser. No. 09/042/909, filed on Mar. 17, 1998, now U.S. Pat. No. 6,136,297, which is a continuation-in-part of U.S. application Ser. No. 08/870,664, filed on Jun. 6, 1997, now U.S. Pat. No. 5,894,017, the substances of which are fully incorporated herein by reference.
  • FIELD OF THE INVENTION
  • [0002]
    The present invention relates to tooth whitening substances, and more particularly, to tooth whitening substances including a polyox resin.
  • BACKGROUND OF THE INVENTION
  • [0003]
    A recognized consumer need is a low cost commercial oral care delivery system that is comfortable to wear that can deliver a sufficient amount of an oral care substance for rapid delivery of an active contained in such substance. In addition a delivery system is needed which does not require extensive user placement manipulation to be certain of good contact for optimal delivery. Furthermore, what is needed is a non-bulky active containment means that will permit the wearer to use the system during social discourse without interfering with the wearer's speech or appearance. Also needed is a containment means that will protect oral care substance from erosion from contact with other oral surfaces and, or saliva.
  • [0004]
    A recognized consumer need is also a low cost commercial oral care substance that is comfortable to wear that can deliver a sufficient amount of an oral care active to a plurality of teeth. Further, there is a continuing need to provide an oral care substance which can adhere to a plurality of teeth as a thin film.
  • SUMMARY OF THE INVENTION
  • [0005]
    An oral care delivery system comprising a strip of material and an oral care composition is provided. The oral care composition comprises a tooth bleaching agent and fluoride. The oral care delivery system is applied to the surfaces of a plurality of teeth and wherein the overall thickness of the oral care delivery system is less than about 1 mm.
  • [0006]
    An oral care delivery system comprising a strip of material and an oral care composition is provided. The oral care composition comprises hydrogen peroxide, and phosphate. The oral care delivery system is applied to the front, incisal edge and lingual surfaces of a plurality of teeth wherein the overall thickness of the oral care delivery system is less than about 1 mm.
  • [0007]
    A method of treating a plurality of teeth comprising adhesively attaching an oral care product comprising a flexible polymeric film and an oral care composition to the facial, incisal edge and lingual surfaces of a plurality of teeth is provided. The oral care composition is pre-applied to the polymeric film and comprises a peroxide, carboxypolymethylene, and fluoride, and wherein the oral care composition is applied as a stripe to the polymeric film.
  • [0008]
    The tooth whitening substance includes a polyox resin and a tooth whitening active. The polyox resin adheres the thin layer to a plurality of teeth for a sufficient time to allow the tooth whitening active to act upon the plurality of teeth.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0009]
    While the specification concludes with claims which particularly point out and distinctly claim the present invention, it is believed that the present invention will be better understood from the following description of preferred embodiments, taken in conjunction with the accompanying drawings, in which like reference numerals identify identical elements and wherein:
  • [0010]
    FIG. 1 is a perspective view of a substantially flat strip of material having rounded corners;
  • [0011]
    FIG. 2 is a perspective view of the flat strip of FIG. 1 coated with an oral care substance for treating teeth and gums;
  • [0012]
    FIG. 3 is a cross-sectional view thereof, taken along section line 3-3 of FIG. 2, disclosing an example of the flat strip of material having a thickness less than that of the substance coated thereon;
  • [0013]
    FIG. 4 is a cross-sectional view showing an alternative embodiment of the present invention, showing shallow pockets in the strip of material, which act as reservoirs for additional oral care substance coated on the strip;
  • [0014]
    FIG. 5 is a cross-sectional plan view thereof, showing an alternative embodiment for applying oral care substances for treating teeth to adjacent teeth having the strip of material conforming thereto and adhesively attached to the teeth by means of the oral care substance located between the teeth and the strip of material;
  • [0015]
    FIG. 6 is a cross-sectional elevation view of a tooth, taken along section line 6-6 of FIG. 5, disclosing the strip of material conforming to and adhesively attached to the teeth by means of the oral care substance located between the teeth and the strip of material;
  • [0016]
    FIG. 7 is a cross-sectional plan view, similar to FIG. 5, showing a strip of material conforming to the teeth and the adjoining soft tissue and adhesively attached to both sides of the teeth by means of the oral care substance located between the teeth and the strip of material;
  • [0017]
    FIG. 8 is a cross-sectional elevation view, taken along section line 8-8 of FIG. 7, showing a strip of material conforming to both the tooth and the adjoining soft tissue and adhesively attached to both sides of the tooth by means of the oral care substance located between the tooth and the strip of material;
  • [0018]
    FIG. 9 is a perspective view of an alternative embodiment of the present invention, disclosing the flat strip of material coated with an oral care substance of FIG. 2 for treating teeth and adjoining soft tissue having a release liner; and
  • [0019]
    FIG. 10 is a cross-sectional view of an alternative embodiment of the present invention, taken along section line 10-10 of FIG. 9, showing a release liner attached to the strip of material by the oral care substance on the strip of material.
  • DETAILED DESCRIPTION OF THE INVENTION
  • [0020]
    The abbreviation “cm”, as used herein, means centimeter. The abbreviation “mm” as used herein, means millimeter.
  • [0021]
    Referring now to the drawings, and more particularly to FIGS. 1 and 2, there is shown a first preferred embodiment of the present invention, generally indicated as 10, representing a delivery system for delivering an oral care substance to an oral surface. Delivery system 10 has a strip of material 12, which is initially substantially flat, preferably with rounded corners.
  • [0022]
    Applied or coated onto strip of material 12 is an oral care substance 14. Preferably, oral care substance 14 is homogeneous, uniformly and continuously coated onto strip of material 12, as shown in FIG. 3. However, oral care substance 14 may alternatively be a laminate or separated layers of components, an amorphous mixture of components, separate stripes or spots or other patterns of different components, or a combination of these structures including a continuous coating of oral care substance 14 along a longitudinal axis of a portion of strip of material 12.
  • [0023]
    As shown in FIG. 4, an alternative embodiment, a strip of material 12 may have shallow pockets 18 formed therein. When oral care substance 14 is coated on a substance-coated side of strip of material 12, additional oral care substance 14 fills shallow pockets 18 to provide reservoirs of additional oral care substance 14.
  • [0024]
    FIGS. 5 and 6 show a delivery system 24 of the present invention applied to a surface of a tooth and plurality of adjacent teeth. Embedded in adjacent soft tissue 20 are a plurality of adjacent teeth 22. Adjacent soft tissue is herein defined as soft tissue surfaces surrounding the tooth structure including: papilla, marginal gingival, gingival sulculus, inter dental gingiva, gingival gum structure on lingual and buccal surfaces up to and including muco-ginival junction and the pallet.
  • [0025]
    In both FIGS. 5 and 6, delivery system 24 represents strip of material 12 and oral care substance 14, with oral care substance 14 on the side of strip of material 12 facing tooth 22. Oral care substance 14 may be pre-applied to strip of material 12, or applied to strip of material 12 by the delivery system user, or applied directly to the teeth 22 and then covered by strip of material conform to the contoured surfaces of tooth 22 and to adjacent soft tissue 20. The strip of flexible material has sufficient flexibility to form to the contours of the oral surface, in this figure the surface being a plurality of adjacent teeth. The strip of material is also readily conformable to tooth surfaces and to the interstitial tooth spaces without permanent deformation when the delivery system is applied. The delivery system is applied without significant pressure.
  • [0026]
    FIGS. 7 and 8 show a delivery system 24 of the present invention applied to both front and rear surfaces of a plurality of adjacent teeth 22 as well as to adjacent soft tissue 20. Delivery system 24 represents strip of material 12 and oral care substance 14, with oral care substance 14 on the side of strip of material 12 facing tooth 22.
  • [0027]
    FIGS. 9 and 10 shows optional release liner 27. Release liner 27 is attached to strip of material 12 by oral care substance 14. Oral care substance 14 is on the side of strip of material 12 facing release liner 27. This side is applied to the tooth and gum surfaces once release liner 27 is removed.
  • [0028]
    Strip of Material
  • [0029]
    The strip of material serves as a protective barrier for the oral care substance. It prevents substantial leaching and/or erosion of the oral care substance by for example, the wearer's lips, tongue, as well as saliva. This allows the active in the oral care composition to act upon the oral surface for an extended period of time, from several minutes to several hours. The term “act upon” is herein defined as bringing about a desired change. For example, if the oral care substance is an anti-microbial substance, it reduces or eliminates proliferation of microbial growth that has an overall positive impact on the oral cavity including teeth and gingival tissue.
  • [0030]
    The strip of material may comprise polymers, natural and synthetic woven materials, non-woven material, foil, paper, rubber, and combinations thereof. The strip of material may be a single layer of material or a laminate of more than one layer. Regardless of the number of layers, the strip of material is substantially water impermeable. Preferably, the material is any type of polymer or combination of polymers that meet the required flexural rigidity and are compatible with oral care substances. Suitable polymers include, but are not limited to, polyethylene, ethylvinylacetate, polyesters, ethylvinyl alcohol and combinations thereof. Examples of polyesters include Mylar® and fluoroplastics such as Teflon®, both manufactured by DuPont. The preferable material is polyethylene. The strip of material is generally less than about 1 mm thick, preferably less than about 0.05 mm thick, and more preferably from about 0.001 to about 0.03 mm thick. A polyethylene strip of material is preferably less than about 0.1 mm thick and more preferably from about 0.005 to about 0.02 mm thick.
  • [0031]
    The shape of the strip of material is any shape and size that covers the desired oral surface. Preferably the strip of material has rounded corners. Rounded corners is defined as not having any sharp angles or points. In one example, the length of the strip of material is from about 2 cm to about 12 cm and preferably from about 4 cm to about 9 cm. The width of the strip of material will also depend upon the oral surface area to be covered. In one example, the width of the strip of material is from about 0.5 cm to about 4 cm and preferably from about 1 cm to about 2 cm.
  • [0032]
    The strip of material may contain shallow pockets. When the oral care substance is coated on a strip of material, additional oral care substance fills shallow pockets to provide reservoirs of additional oral care substance. Additionally, the shallow pockets help to provide texture to the delivery system. The film will preferably have an array of shallow pockets. Generally, the shallow pockets are approximately 0.4 mm across and 0.1 mm deep. When shallow pockets are included in the strip of material and oral care substances are applied to it in various thicknesses, the overall thickness of the delivery system is generally less than about 1 mm. Preferably, the overall thickness is less than about 0.5 mm.
  • [0033]
    Flexural stiffness is a material property that is a function of a combination of strip thickness, width, and material modulus of elasticity. This test is a method for measuring the rigidity of polyolefin film and sheeting. It determines the resistance to flexure of a sample by using a strain gauge affixed to the end of a horizontal beam. The opposite end of the beam presses across a strip of the sample to force a portion of the strip into a vertical groove in a horizontal platform upon which the sample rests. A microammeter, wired to the strain gauge is calibrated in grams of deflection force. The rigidity of the sample is read directly from the microammeter and expressed as grams per centimeter of sample strip width. In the present invention, the strip of material has a flexural stiffness of less than about 5 grams/cm as measured on a Handle-O-Meter, model #211-300, available from Thwing-Albert Instrument Co. of Philadelphia, Pa., as per test method ASTM D2923-95. Preferably, the strip of material has a flexural stiffness less than about 3 grams/cm, more preferably less than about 2 grams/cm, and most preferably from about 0.1 grams/cm to about 1 grams/cm. Preferably, the flexural stiffness of the strip of material is substantially constant and does not change during normal use. For example, the strip of material does not need to be hydrated for the strip to achieve the low flexural stiffness in the above-specified ranges.
  • [0034]
    This relatively low stiffness enables the strip of material to cover the contours of the oral surface with very little force being exerted. That is, conformity to the contours of the oral surface of the wearer's mouth is maintained because there is little residual force within the strip of material to cause it to return to its shape just prior to its application to the oral surface, i.e. substantially flat. The strip of material's flexibility enables it to contact soft tissue over an extended period of time without irritation. The strip of material does not require pressure forming it against the oral surface.
  • [0035]
    The strip of material is held in place on the oral surface by adhesive attachment provided by the oral care substance. The viscosity and general tackiness of the oral care substance cause the strip of material to be adhesively attached to the oral surface without substantial slippage from the frictional forces created by the lips, teeth, tongue and other oral surfaces rubbing against the strip of material while talking, drinking, etc. However, this adhesion to the oral surface is low enough to allow the strip of material to be easily removed by the wearer by simply peeling off the strip of material using ones finger, fingernail or rubbing with a soft implement such as a cotton balls and swabs or gauze pads. The delivery system is easily removable from the oral surfaces without the use of an instrument, a chemical solvent or agent or excessive friction. The chemical solvents include organic solvent known for use in the oral cavity such as alcohols, and other safe solvents such as water, that can be used to dilute the gelling agent.
  • [0036]
    The peel force required to remove the strip of material from the oral surface is from about 1 gram to about 50 grams for a 1.5 cm strip width (approximately 17 grams/cm) is all that is required. Preferably, the peel force is from about 10 grams to about 40 grams and more preferably from about 20 grams to about 30 grams. The low peel force is desired for consumer handling purposes. The low peel force is possible because of the non-aggressive nature of the oral care substance necessary to adhere the strip of material having lower flexural stiffness. That is a strip of material having high flexural stiffness higher would require an aggressive adhesive to stop the strip of material from pulling it away from the contours of the oral surface it is attached to.
  • [0037]
    The strip of material may be formed by several of the film making processes known in the art. Preferably, a strip of material made of polyethylene is made by a blown process or a cast process. Other processes, including extrusion or processes that do not affect the flexural rigidity of the strip of material are also feasible. Additionally, the oral care substance may be incorporated onto the strip during the processing of the strip. The oral care substance may be a laminate on the strip.
  • [0038]
    Oral Care Substances
  • [0039]
    The oral care substance preferably contains an active at a level where upon directed use, promotes the benefit sought by the wearer without detriment to the oral surface it is applied to. Examples of the oral conditions these actives address include, but, are not limited to appearance and structural changes to teeth, whitening, stain bleaching, stain removal, plaque removal, tartar removal, cavity prevention and treatment, inflamed and, or bleeding gums, mucosal wounds, lesions, ulcers, aphthous ulcers, cold sores tooth abscesses, and the elimination of mouth malodor resulting from the conditions above and other causes such as microbial proliferation.
  • [0040]
    The amount of oral care substance applied to the strip of material or oral surface depends upon the size and capacity of the piece of material, concentration of the active, and the desired benefit sought. Generally, less than about 1 gram of oral care substance is required. Preferably, from about 0.05 grams to about 0.5 grams and more preferably from about 0.1 gram to about 0.4 grams of the oral care substance is used. The amount of oral care substance per square cm of material is less than about 0.2 grams/cm2, preferably from about 0.005 to about 0.1 grams/cm2, and more preferably from about 0.01 grams/cm2 to about 0.04 grams/cm2.
  • [0041]
    The oral care substance of the present invention can be in the form of a viscous liquid, paste, gel, solution, or other suitable that can provide sufficient adhesion. Preferably, the oral care substance is in the form of a gel. The oral care substance will have a viscosity of from about 200 to about 1,000,000 cps at low (less than one 1/seconds). Preferably, the viscosity is from about 100,000 to about 800,000 cps and more preferably from about 400,000 to about 600,000 cps.
  • [0042]
    Oral Care Actives
  • [0043]
    Suitable for oral care actives include any material that is generally considered as safe for use in the oral cavity that provides changes to the overall health of the oral cavity, and specifically the condition of the oral surfaces the oral care substance contacts. The level of oral care substance in the present invention is from about 0.01% to about 40%, preferably from about 0.1% to about 20%, more preferably from about 0.5% to about 10%, and most preferably from about 1% to about 7%, by weight of the oral care substance.
  • [0044]
    Oral care compositions or substances of the present invention may include many of the actives previously disclosed in the art. The following is a non all-inclusive list of oral care actives that may be used in the present invention:
  • [0045]
    1. Teeth Whitening Actives
  • [0046]
    Teeth whitening actives may be included in the oral care substance of the present invention. The actives suitable for whitening are selected from the group consisting of the peroxides, metal chlorites, perborates, percarbonates, peroxyacids, and combination thereof. Suitable peroxide compounds include hydrogen peroxide, calcium peroxide, carbamide peroxide, and mixtures thereof. Most preferred is carbamide peroxide. Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite. Additional whitening actives may be hypochlorite and chlorine dioxide. The preferred chlorite is sodium chlorite.
  • [0047]
    2. Phosphates
  • [0048]
    Anti-tartar agents known for use in dental care products includes phosphates. Phosphates include pyrophosphates, polyphosphates, polyphosphonates and mixtures thereof. Pyrophosphates are among the best known for use in dental care products. Pyrophosphate ions are delivered to the teeth derive from pyrophosphate salts. The pyrophosphate salts useful in the present compositions include the dialkali metal pyrophosphate salts, tetra-alkali metal pyrophosphate salts, and mixtures thereof. Disodium dihydrogen pyrophosphate (Na2H2P2O7), tetrasodium pyrophosphate (Na4P2O7), and tetrapotassium pyrophosphate (K4P2O7) in their unhydrated as well as hydrated forms are the preferred species. While any of the above mentioned pyrophosphate salts may be used, tetrasodium pyrophosphate salt is preferred.
  • [0049]
    The pyrophosphate salts are described in more detail in Kirk & Othmer, Encyclopedia of Chemical Technology, Third Edition, Volume 17, Wiley-Interscience Publishers (1982), incorporated herein by reference in its entirety, including all references incorporated into Kirk & Othmer. Additional anticalculus agents include pyrophosphates or polyphosphates disclosed in U.S. Pat. No. 4,590,066 issued to Parran & Sakkab on May 20, 1986; polyacrylates and other polycarboxylates such as those disclosed in U.S. Pat. No. 3,429,963 issued to Shedlovsky on Feb. 25, 1969 and U.S. Pat. No. 4,304,766 issued to Chang on Dec. 8, 1981; and U.S. Pat. No. 4,661,341 issued to Benedict & Sunberg on Apr. 28, 1987; polyepoxysuccinates such as those disclosed in U.S. Pat. No. 4,846,650 issued to Benedict, Bush & Sunberg on Jul. 11, 1989; ethylenediaminetetraacetic acid as disclosed in British Patent No. 490,384 dated Feb. 15, 1937; nitrilotriacetic acid and related compounds as disclosed in U.S. Pat. No. 3,678,154 issued to Widder & Briner on Jul. 18, 1972; polyphosphonates as disclosed in U.S. Pat. No. 3,737,533 issued to Francis on Jun. 5, 1973, U.S. Pat. No. 3,988,443 issued to Ploger, Schmidt-Dunker & Gloxhuber on Oct. 26, 1976 and U.S. Pat. No. 4,877,603 issued to Degenhardt & Kozikowski on Oct. 31, 1989; all of these patents are incorporated herein by reference. Anticalculus phosphates include potassium and sodium pyrophosphates; sodium tripolyphosphate; diphosphonates, such as ethane-1-hydroxy-1,1-diphosphonate, 1-azacycloheptane-1,1-diphosphonate, and linear alkyl diphosphonates; linear carboxylic acids; and sodium zinc citrate.
  • [0050]
    Agents to may be used in place of or in combination with the pyrophosphate salt include such known materials as synthetic anionic polymers including polyacrylates and copolymers of maleic anhydride or acid and methyl vinyl ether (e.g., Gantrez), as described, for example, in U.S. Pat. No. 4,627,977, to Gaffar et al., the disclosure of which is incorporated herein by reference in its entirety; as well as, e.g., polyamino propoane sulfonic acid (AMPS), zinc citrate trihydrate, polyphosphates (e.g., tripolyphosphate; hexametaphosphate), diphosphonates (e.g., EHDP; AHP), polypeptides (such as polyaspartic and polyglutamic acids), and mixtures thereof.
  • [0051]
    3. Fluoride Ion Source
  • [0052]
    Fluoride ion sources are well know for use in oral care compositions as anticaries agents. Fluoride ions are contained in a number of oral care compositions for this purpose, particularly toothpastes. Patents disclosing such toothpastes include U.S. Pat. No. 3,538,230, Nov. 3, 1970 to Pader et al; U.S. Pat. No. 3,689,637, Sep. 5, 1972 to Pader; U.S. Pat. No. 3,711,604, Jan. 16, 1973 to Colodney et al; U.S. Pat. No. 3,911,104, Oct. 7, 1975 to Harrison; U.S. Pat. No. 3,935,306, Jan. 27, 1976 to Roberts et al; and U.S. Pat. No. 4,040,858, Aug. 9, 1977 to Wason.
  • [0053]
    Application of fluoride ions to dental enamel serves to protect teeth against decay. A wide variety of fluoride ion-yielding materials can be employed as sources of soluble fluoride in the instant compositions. Examples of suitable fluoride ion-yielding materials are found in Briner et al; U.S. Pat. No. 3,535,421; issued Oct. 20, 1970 and Widder et al; U.S. Pat. No. 3,678,154; issued Jul. 18, 1972, both patents being incorporated herein by reference. Preferred fluoride ion sources for use herein include sodium fluoride, potassium fluoride and ammonium fluoride. Sodium fluoride is particularly preferred. Preferably the instant compositions provide from about 50 ppm to 10,000 ppm, more preferably from about 100 to 3000 ppm, of fluoride ions in the aqueous solutions that contact dental surfaces when used with the strip of material used in the mouth.
  • [0054]
    4. Antimicrobial Agents
  • [0055]
    Antimicrobial agents can also be present in the oral care compositions or substances of the present invention. Such agents may include, but are not limited to, 5-chloro-2-(2,4-dichlorophenoxy)-phenol, commonly referred to as triclosan, and described in The Merck Index, 11th ed. (1989), pp. 1529 (entry no. 9573) in U.S. Pat. No. 3,506,720, and in European Patent Application No. 0,251,591 of Beecham Group, PLC, published Jan. 7, 1988; phthalic acid and its salts including, but not limited to those disclosed in U.S. Pat. No. 4,994,262, Feb. 19, 1991, substituted monoperthalic acid and its salts and esters as disclosed in U.S. Pat. Nos. 4,990,329, Feb. 5, 1991, 5,110,583, May 5, 1992 and 4,716,035, Dec. 29, 1987, all to Sampathkumar; preferably magnesium monoperoxy phthalate, chlorhexidine (Merck Index, no. 2090), alexidine (Merck Index, no. 222; hexetidine (Merck Index, no. 4624); sanguinarine (Merck Index, no. 8320); benzalkonium chloride (Merck Index, no. 1066); salicylanilide (Merck Index, no. 8299); domiphen bromide (Merck Index, no. 3411); cetylpyridinium chloride (CPC) (Merck Index, no. 2024; tetradecylpyridinium chloride (TPC); N-tetradecyl-4-ethylpyridinium chloride (TDEPC); octenidine; delmopinol, octapinol, and other piperidino derivatives; nicin preparations; zinc/stannous ion agents; antibiotics such as augmentin, amoxicillin, tetracycline, doxycycline, minocycline, and metronidazole; and analogs and salts of the above; essential oils including thymol, geraniol, carvacrol, citral, hinokitiol, eucalyptol, catechol (particularly 4-allyl catechol) and mixtures thereof; methyl salicylate; hydrogen peroxide; metal salts of chlorite and mixtures of all of the above.
  • [0056]
    5. Anti-Inflammatory Agents
  • [0057]
    Anti-inflammatory agents can also be present in the oral care compositions or substances of the present invention. Such agents may include, but are not limited to, non-steroidal anti-inflammatory agents or NSAIDs such as ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, aspirin, ketoprofen, piroxicam and meclofenamic acid. Use of NSAIDs such as Ketorolac are claimed in U.S. Pat. No. 5,626,838, issued May 6, 1997, herein incorporated by reference. Disclosed therein are methods of preventing and, or treating primary and reoccurring squamous cell carcinoma of the oral cavity or oropharynx by topical administration to the oral cavity or oropharynx an effective amount of an NSAID.
  • [0058]
    6. Nutrients
  • [0059]
    Nutrients may improve the condition of the oral cavity and can be included in the oral care compositions or substances of the present invention. Nutrients include minerals, vitamins, oral nutritional supplements, enteral nutritional supplements, and mixtures thereof.
  • [0060]
    Minerals that can be included with the compositions of the present invention include calcium, phosphorus, fluoride, zinc, manganese, potassium and mixtures thereof. These minerals are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., (1997, pp 10-17; incorporated herein by reference.
  • [0061]
    Vitamins can be included with minerals or used separately. Vitamins include Vitamins C and D, thiamine, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamin, para-aminobenzoic acid, bioflavonoids, and mixtures thereof. Such vitamins are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., (1997, pp. 3-10; incorporated herein by reference.
  • [0062]
    Oral nutritional supplements include amino acids, lipotropics, fish oil, and mixtures thereof, as disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ©1997, pp. 54-54e; incorporated herein by reference. Amino acids include, but, are not limited to L-Tryptophan, L-Lysine, Methionine, Threonine, Levocarnitine or L-carnitine and mixtures thereof. Lipotropics include, but, are not limited to choline, inositol, betaine, linoleic acid, linolenic acid, and mixtures thereof. Fish oil contains large amounts of Omega-3 (N-3) Polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid.
  • [0063]
    Entenal nutritional supplements include, but, are not limited to protein products, glucose polymers, corn oil, safflower oil, medium chain triglycerides as disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., © 1997, pp. 55-57; incorporated herein by reference.
  • [0064]
    7. Enzymes
  • [0065]
    An individual or combination of several compatible enzymes can be included in the oral care composition or substance of the present invention. Enzymes are biological catalysts of chemical reactions in living systems. Enzymes combine with the substrates on which they act forming an intermediate enzyme-substrate complex. This complex is then converted to a reaction product and a liberated enzyme which continues its specific enzymatic function.
  • [0066]
    Enzymes provide several benefits when used for cleansing of the oral cavity. Proteases break down salivary proteins which are absorbed onto the tooth surface and form the pellicle; the first layer of resulting plaque. Proteases along with lipases destroy bacteria by lysing proteins and lipids which form the structural component of bacterial cell walls and membranes. Dextranases break down the organic skeletal structure produced by bacteria that forms a matrix for bacterial adhesion. Proteases and amylases, not only present plaque formation, but also prevent the development of calculus by breaking-up the carbohydrate-protein complex that binds calcium, preventing mineralization.
  • [0067]
    Enzymes useful in the present invention include any of the commercially available proteases, glucanohydrolases, endoglycosidases, amylases, mutanases, lipases and mucinases or compatible mixtures thereof. Preferred are the proteases, dextranases, endoglycosidases and mutanases, most preferred being papain, endoglycosidase or a mixture of dextranase and mutanase. Additional enzymes suitable for use in the present invention are disclosed in U.S. Pat. No. 5,000,939 to Dring et al., Mar. 19, 1991; U.S. Pat. No. 4,992,420 to Neeser, Feb. 12, 1991; U.S. Pat. No. 4,355,022 to Rabussay, Oct. 19, 1982; U.S. Pat. No. 4,154,815 to Pader, May 15, 1979; U.S. Pat. No. 4,058,595 to Colodney, Nov. 15, 1977; U.S. Pat. No. 3,991,177 to Virda et al., Nov. 9, 1976 and U.S. Pat. No. 3,696,191 to Weeks, Oct. 3, 1972; all incorporated herein by reference.
  • [0068]
    8. Mouth and Throat Products
  • [0069]
    Other materials that can be used with the present invention include commonly known mouth and throat products. Such products are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ©1997, pp. 520b-527; incorporated herein by reference. These products include, but, are not limited to anti-fungal, antibiotic and analgesic agents.
  • [0070]
    9. Antioxidants
  • [0071]
    Antioxidants are generally recognized as useful in compositions such as those of the present invention. Antioxidants are disclosed in texts such as Cadenas and Packer, The Handbook of Antioxidants, © 1996 by Marcel Dekker, Inc., incorporated herein by reference. Antioxidants that may be included in the oral care composition or substance of the present invention include, but are not limited to Vitamin E, ascorbic acid, Uric acid, carotenoids, Vitamin A, flavonoids and polyphenols, herbal antioxidants, melatonin, aminoindoles, lipoic acids and mixtures thereof.
  • [0072]
    10. H-2 Antagonists
  • [0073]
    Histamine-2 (H-2 or H@) receptor antagonist compounds (H-2 antagonists) may be used in the oral care composition of the present invention. As used herein, selective H-2 antagonists are compounds that block H-2 receptors, but do not have meaningful activity in blocking histamine-1 (H-1 or H!) receptors. Selective H-2 antagonists stimulates the contraction of smooth muscle from various organs, such as the gut and bronchi; this effect can be suppressed by low concentrations of mepyramine—a typical antihistaminic drug. The pharmacological receptors involved in these mepyramine-sensitive histamine responses have been defined as H-1 receptors (Ash, A. S. F. & H. O. Schild, Brit. J. Pharmacol Chemother., Vol. 27 (1966), p. 427, incorporated herein by reference). Histamine also stimulates the secretion of acid by the stomach (Loew, E. R. & O. Chickering, Proc. Soc. Exp. Biol. Med., Vol. 48 (1941), p. 65, incorporated herein by reference), increases the heart rate (Trendelenburg, U., J. Pharmacol., Vol. 130 (1960), p. 450, incorporated herein by reference), and inhibits contractions in the rat uterus (Dews, P. B. & J. D. P. Graham, Brit. J. Pharmacol. Chemother., Vol. 1 (1946), p. 278, incorporated herein by reference); these actions cannot be antagonized by mepyramine and related drugs. The H-2 antagonists useful in the oral care compositions or substances are those that blockade the receptors involved in mepyramine-insensitive, non-H-1 (H-2), histamine responses, and do not blockade the receptors involved in mepyramine-sensitive histamine responses.
  • [0074]
    Selective H-2 antagonists are those compounds found to be H-2 antagonists through their performance in classical preclinical screening tests for H-2 antagonist function. Selective H-2 antagonists are identified as compounds which can be demonstrated to function as competitive or non-competitive inhibitors of histamine-mediated effects in those screening models specifically dependent upon H-2 receptor function, but to lack significant histamine antagonist activity in those screening models dependent upon H-1 receptor function. Specifically, this includes compounds that would be classified as described by Black, J. W., W. A. M. Duncan, C. J. Durant, C. R. Ganellin & E. M. Parsons, “Definition and Antagonism of Histamine H@-Receptors”, Nature, Vol. 236 (Apr. 21, 1972), pp. 385-390 (Black), incorporated herein by reference, as H-2 antagonists if assessed as described by Black through testing with the guinea pig spontaneously beating right atria in vitro assay and the rat gastric acid secretion in vivo assay, but shown to lack in significant H-1 antagonist activity relative to H-2 antagonist activity, if assessed as described by Black with either the guinea pig ileum contraction in vitro assay or the rat stomach muscle contraction in vivo assay. Preferably selective H-2 antagonists demonstrate no significant H-1 activity at reasonable dosage levels in the above H-1 assays. Typical reasonable dosage level is the lowest dosage level at which 90% inhibition of histamine, preferably 99% inhibition of histamine, is achieved in the above H-2 assays.
  • [0075]
    Selective H-2 antagonists include compounds meeting the above criteria which are disclosed in U.S. Pat. Nos. 5,294,433 and 5,364,616 Singer et al., issued Mar. 15, 1994 and Nov. 15, 1994 respectively and assigned to Procter & Gamble; both herein incorporated by reference. wherein the selective H-2 antagonist is selected from the group consisting of cimetidine, etintidine, ranitidine, ICIA-5165, tiotidine, ORF-17578, lupitidine, donetidine, famotidine, roxatidine, pifatidine, lamtidine, BL-6548, BMY-25271, zaltidine, nizatidine, mifentidine, BMY-52368, SKF-94482, BL-6341A, ICI-162846, ramixotidine, Wy-45727, SR-58042, BMY-25405, loxtidine, DA-4634, bisfentidine, sufotidine, ebrotidine, HE-30-256, D-16637, FRG-8813, FRG-8701, impromidine, L-643728, and HB-408. 4. Particularly preferred is cimetidine (SKF-92334), N-cyano-N′-methyl-N″-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine:
    Figure US20080025927A1-20080131-C00001
  • [0076]
    Cimetidine is also disclosed in the Merck Index, 11th edition (1989), p. 354 (entry no. 2279), and Physicians' Desk Reference, 46th edition (1992), p. 2228. Related preferred H-2 antagonists include burimamide and metiamide.
  • [0077]
    As previously mentioned, the oral care substance of the present invention can be in a variety forms, but, most preferable is a gel, particularly an aqueous gel. The gel is a high viscosity matrix formed from gelling agents known in the art. These gelling agents are safe for oral use, do not readily dissolve in saliva, and do not react with or inactivate the oral care compounds incorporated into them. Generally, the gelling agent is a swellable polymer. Furthermore, the gel formed with these agents provide sufficient adhesive attachment of the film material to the targeted area of the mouth. The level of gelling agent to form the gel composition is from about 0.1% to about 15%, preferably from about 1% to about 10%, more preferably from about 2% to about 8%, and most preferably from about 4% to about 6%, by weight of the oral care composition or substance.
  • [0078]
    Suitable gelling agents useful in the present invention include carboxypolymethylene, carboxymethyl cellulose, carboxypropyl cellulose, polyoxamers, carrageenan, Veegum, carboxyvinyl polymers, and natural gums such as gum karaya, xanthan gum, Guar gum, gum arabic, gum tragacanth, and mixtures thereof. The preferable gelling agent for use in the present invention is carboxypolymethylene, obtained from B. F. Goodrich Company under the tradename Carbopol®. Particularly preferable Carbopols include Carbopol 934, 940, 941, 956 and mixtures thereof. Particularly preferred is Carbopol 956. Carboxypolymethylene is a slightly acidic vinyl polymer with active carboxyl groups. The normal concentration of various carboxypolymethylene resins in water, according to the manufacturer, is below about 2%. However, it has been found that by preparing supersaturated carboxypolymethylene compositions having an absolute concentration in the ranges specified above, suitable high viscosity oral gel compositions may be prepared.
  • [0079]
    The concentrated carboxypolymethylene gels have a number of important characteristics in addition to high viscosity. Enough carboxypolymethylene is added to the oral gel compositions beyond that required to provide high viscosity such that a significant quantity of saliva or water is required to lower the viscosity to the point that the composition may be diluted and washed out by saliva. The concentrated carboxypolymethylene composition also has a unique tackiness or stickiness which retains and seals the strip material against the targeted oral cavity surface it is affixed to, particularly teeth. However, care should be taken to avoid too much carboxypolymethylene thereby making insertion or withdrawal of the strip material difficult.
  • [0080]
    If the oral care substance is an aqueous gel, the water present in the gel compositions should preferably be deionized and free of organic impurities. Water comprises from about 0.1% to 95%, preferably from about 5% to about 90%, and most preferably from about 10% to about 80%, by weight of the oral care substance. This amount of water includes the free water that is added plus that amount that is introduced with other materials.
  • [0081]
    A pH adjusting agent may also be added to optimize the storage stability of the gel and to make the substance safe for oral tissue. These pH adjusting agents, or buffers, can be any material which is suitable to adjust the pH of the oral care substance. Suitable materials include sodium bicarbonate, sodium phosphate, sodium hydroxide, ammonium hydroxide, sodium stannate, triethanolamine, citric acid, hydrochloric acid, sodium citrate, and combinations thereof. The pH adjusting agents are added in sufficient amounts so as to adjust the pH of the gel composition to about 4.5 to about 11, preferably from about 5.5 to about 8.5, and more preferably from about 6 to about 7. pH adjusting agents are generally present in an amount of from about 0.01% to about 15% and preferably from about 0.05% to about 5%, by weight of the oral care substance.
  • [0082]
    While the gel described above provides sufficient adhesiveness, additional gelling agents may also be included in the formula to help the active ingredients adhere to the tissues of the oral cavity. Suitable agents include both polymers with limited water solubility as well as polymers lacking water solubility. These polymers deposit a thin film on both the oral cavity's soft and hard tissues when saliva combines with the instant composition. Suitable limited water solubility adhesives include: hydroxy ethyl or propyl cellulose. Adhesives lacking water solubility include: ethyl cellulose and polyox resins. Another possible adhesive suitable for use in the instant composition is polyvinylpyrrolidone with a molecular weight of about 50,000 to about 300,000. Still another possible adhesive suitable for use in the instant composition is a combination of Gantrez and the semisynthetic, water-soluble polymer carboxymethyl cellulose.
  • [0083]
    An additional carrier material may also be added to the oral care substance. Carrier materials can be humectants. Suitable humectants include glycerin, sorbitol, polyethylene glycol, propylene glycol, and other edible polyhydric alcohols. Humectants are generally present in an amount of from about 10% to about 95% and preferably from about 50% to about 80%, by weight of the oral care substance or composition. In addition to the above materials of the gel of the present invention, a number of other components can also be added to the oral care substance. Additional components include, but are not limited to, flavoring agents, sweetening agents, xylitol, opacifiers, coloring agents, and chelants such as ethylenediaminetetraacetic acid. These additional ingredients can also be used in place of the compounds disclosed above.
  • [0084]
    The Release Liner
  • [0085]
    The release liner may be formed from any material which exhibits less affinity for the oral care substance than the oral care substance exhibits for itself and for the strip of material. The release liner preferably comprises a rigid sheet of material such as polyethylene, paper, polyester, or other material which is then coated with a non-stick type material. The release liner material may be coated with wax, silicone, teflon, fluoropolymers, or other non-stick type materials. A preferred release liner is Scotchpak®, produced by 3M. The release liner may be cut to substantially the same size and shape as the strip of material or the release liner may be cut larger than the strip of material to provide a readily accessible means for separating the material from the strip. The release liner may be formed from a brittle material which cracks when the strip is flexed or from multiple pieces of material or a scored piece of material. Alternative, the release liner may be in two overlapping pieces such as a typical adhesive strip bandage design. A further description of materials suitable as release agents is found in Kirk-Othmer Encyclopedia of Chemical Technology, Fourth Edition, Volume 21, pp. 207-218, incorporated herein by reference.
  • [0086]
    All documents cited are, in relevant part, incorporated herein by reference; the citation of any document is not to be construed as an admission that it is prior art with respect to the present invention.
  • EXAMPLES
  • [0087]
    The strip of material 12 is preferably a 0.013 thick piece of polyethylene film. The film preferably has an array of shallow pockets, typically 0.4 mm across and 0.1 mm deep. The strip of material 12 has a flexural stiffness of about 0.6 grams/centimeter as measured on a Handle-O-Meter, model #211-300, available from Thwing-Albert Instrument Co. of Philadelphia, Pa., as per test method ASTM D2923-95.
  • [0088]
    An example of a tooth whitener is a gel described as follows: combine 70% glycerin, 5% carboxypolymethylene, 10% carbamide peroxide, and 15% water adjusted to pH 6.5 with sodium hydroxide. Mix until homogeneous. Commercial tooth whiteners, such as Opalescence and Nu-Pro Gold are also operable with the delivery system of the present invention.
  • [0089]
    An example of an oral gel composition of the subject invention containing H-2 antagonists, made by routine processing methods, comprises mixing 2.50% hydroxyethyl cellulose, 0.09% sodium fluoride, 0.05% sodium saccharin, 1.00% ranitidine, and purified water q.s.
  • [0090]
    An example of an oral gel composition of the subject invention containing enzymes, made by routine processing methods, comprises 61.814% sorbitol, 0.314% Carbopol 956, 0.534% xantham gum, 1.132% citric acid, 6.291 sodium citrate, 5.033% sodium lauroyl sarcosinate (30% solution), 7.864% endoglycosidase (3.2% solution), 0.305% sodium fluoride, water q.s.
  • [0091]
    An example of an oral gel composition of the subject invention containing antimicrobial actives, made by routine processing methods, comprises from 21.2% to 21.5% glycerin, 6.0% Carbopol 956, 40.0% propylene glycol, 2.5% sodium hydroxide (50% solution), from 0.1% to 0.3% Triclosan and water qs.
  • [0092]
    Method of Use
  • [0093]
    In practicing the present invention, a strip of material is applied to the desired oral surface by the wearer. The side of the material facing the oral surface is coated with a oral care substance that is preferably in a highly viscous state. This oral care substance provides a vehicle for the active as well as tackiness between the oral surfaces and the strip of material, holding the strip of material in place for extended periods of time. For oral care actives other than teeth whiteners, the period over which the strip of material is used is from about 1 minute to about 8 hours for actives that require long term diffusion into the oral surface, preferably from about 1 to about 120 minutes and most preferably from about 30 to about 60 minutes.
  • [0094]
    There are many methods using the present invention to reduce or eliminate the proliferation of microbial and bacterial growth in the oral cavity. Such growth is known to be responsible for development of oral conditions including, but not limited to mouth and breath odor, plaque accumulation, gingival inflammation and bleeding of the gum tissue. Prolonged attachment by certain oral bacteria has also been implicated in more progressive periodontal diseases. Numerous articles exist in the literature that describe the advantages of controlling bacterial growth in regard to maintaining good oral well-being of the individual.
  • [0095]
    Among these methods is one that comprises the steps of first applying a gel comprising an antimicrobial agent, preferably in a highly viscous state, to the strip of material of the present invention. The strip of material with the applied gel is applied to the oral surface, preferably the front surface of a plurality of adjacent teeth and their surrounding gum tissue, with adhesive attachment between the strip of material and the oral surface. This provides sufficient attachment for holding the delivery system in place for a sufficient time to allow the antimicrobial agent to act upon the oral surface. The conformable strip is removed after a period of time for the antimicrobial agent to be effective. Such a period includes from just prior to retiring or upon awakening. Whenever the strip is removed the excess gel residue remaining on the applied surface may be removed by means such as brushing and, or rinsing. Such a method has been found particularly useful in the eliminating mouth odors generated while sleeping.
  • [0096]
    The strip of material readily conforms to the oral care surface by lightly pressing it there against. The strip of material is easily removed by the wearer by peeling it off using a finger or fingernail. Preferably each successive treatment uses a fresh strip of material.
  • [0097]
    In the situation were the oral care surface is the surface of teeth, is not unnecessary to prepare the teeth surface before applying the delivery system of the present invention. For example, the wearer may or may not choose to brush his teeth or rinse his mouth before applying the delivery system. The surfaces of the teeth are not required to be dried or to be excessively wet with saliva or water before the strip of material is applied.
  • [0098]
    Preferably, the strip of material and substances almost unnoticeable when worn, preferably transparent. Thinness of the strip of material may also provide higher temperature of the oral surface wherein the warmer temperature accelerates the rate of diffusion of the active material into the oral surface.
  • [0099]
    When the wearer removes the strip of material from the tooth, there may be a residual amount of oral care substance remaining on the surface. The amount residual oral care substance, however, will not be great since it has affinity for both the film and for itself. Any residual oral care substance may be easily removed by wiping, brushing or rinsing the oral surface.
  • [0100]
    While particular embodiments of the present invention have been illustrated and described, it will be obvious to those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention, and it is intended to cover in the appended claims all such modifications that are within the scope of the invention.

Claims (17)

  1. 1. A method of bleaching a plurality of teeth, the teeth having facial, lingual, and incisal surfaces, comprising:
    a) adhesively attaching a tooth bleaching product comprising a flexible film and a tooth bleaching composition to the facial and lingual surfaces of a plurality of teeth, wherein the tooth bleaching composition comprises a tooth bleaching agent, polyvinyl pyrrolidone, and water;
    b) conforming the flexible film to the facial and lingual surfaces of the plurality of teeth;
    c) repeating 1(a) and 1(b), wherein each repetition utilizes a fresh tooth bleaching product; and
    wherein the tooth bleaching product can be used without interfering with the wearer's speech, and wherein the tooth bleaching product has a thickness of less than about 1 mm.
  2. 2. The method of claim 1, wherein the tooth bleaching composition further comprises a second thickening agent.
  3. 3. The method of claim 2, wherein the second thickening agent is selected from the group consisting of cellulose, carrageenan, veegum, natural gums, and mixtures thereof.
  4. 4. The method of claim 2, wherein the second thickening agent comprises xanthan gum and carrageenan.
  5. 5. The method of claim 3, wherein the tooth bleaching composition further comprises a flavorant and a sweetening agent.
  6. 6. The method of claim 1, wherein the tooth bleaching composition further comprises a humectant selected from the group consisting of polyethylene glycol, propylene glycol, glycerin, and sorbitol.
  7. 7. The method of claim 1, wherein the amount of water is between about 0.1% and about 10% by weight of the tooth bleaching composition.
  8. 8. The method of claim 1, further comprising peeling the flexible film from the plurality of teeth.
  9. 9. The method of claim 3, wherein the tooth bleaching composition further comprises a phosphate
  10. 10. The method of claim 1, wherein the tooth bleaching product is substantially flat prior to use.
  11. 11. The method of claim 1, wherein the second thickening agent is carboxypolymethylene.
  12. 12. The method of claim 1, wherein the amount of carboxypolymethylene is between about 0.1% and about 15% by weight of the tooth bleaching composition.
  13. 13. The method of claim 1, wherein the tooth bleaching composition further comprises a humectant in amount between about 50% and about 80% by weight of the tooth bleaching composition.
  14. 14. The method of claim 1, wherein the pH of the tooth bleaching composition is between about 4.5 and about 5.5.
  15. 15. The method of claim 1, wherein the tooth bleaching product further comprises one or more essential oils.
  16. 16. The method of claim 1, wherein the tooth bleaching product further comprises a glucose polymer.
  17. 17. The method of claim 1, wherein the tooth bleaching product further comprises a triglyceride.
US11888147 1997-06-06 2007-07-31 Delivery system for an oral care substance Abandoned US20080025927A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US08870664 US5894017A (en) 1997-06-06 1997-06-06 Delivery system for an oral care substance using a strip of material having low flexural stiffness
US09042909 US6136297A (en) 1997-06-06 1998-03-17 Delivery system for an oral care substance using a strip of material having low flexural stiffness
US09196364 US6096328A (en) 1997-06-06 1998-11-19 Delivery system for an oral care substance using a strip of material having low flexural stiffness
US60522000 true 2000-06-28 2000-06-28
US09681729 US6551579B2 (en) 1997-06-06 2001-05-29 Delivery systems for a tooth whitener
US10410037 US20030211056A1 (en) 1997-06-06 2003-04-09 Tooth whitening substances
US11157769 US20050238591A1 (en) 1997-06-06 2005-06-21 Tooth whitening substances
US11638844 US20070086961A1 (en) 1997-06-06 2006-12-14 Tooth whitening substances
US11824056 US20070248634A1 (en) 1997-06-06 2007-06-29 Delivery system for an oral care substance
US11888147 US20080025927A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11888147 US20080025927A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance

Publications (1)

Publication Number Publication Date
US20080025927A1 true true US20080025927A1 (en) 2008-01-31

Family

ID=46282483

Family Applications (14)

Application Number Title Priority Date Filing Date
US09196364 Expired - Lifetime US6096328A (en) 1997-06-06 1998-11-19 Delivery system for an oral care substance using a strip of material having low flexural stiffness
US09864772 Abandoned US20020012685A1 (en) 1997-06-06 2001-05-24 Delivery systems for a tooth whitener and methods of using the same
US09864686 Abandoned US20020006388A1 (en) 1997-06-06 2001-05-24 Delivery systems for a tooth whitener
US09681729 Expired - Lifetime US6551579B2 (en) 1997-06-06 2001-05-29 Delivery systems for a tooth whitener
US10410037 Abandoned US20030211056A1 (en) 1997-06-06 2003-04-09 Tooth whitening substances
US11157769 Abandoned US20050238591A1 (en) 1997-06-06 2005-06-21 Tooth whitening substances
US11638844 Abandoned US20070086961A1 (en) 1997-06-06 2006-12-14 Tooth whitening substances
US11824056 Abandoned US20070248634A1 (en) 1997-06-06 2007-06-29 Delivery system for an oral care substance
US11888299 Abandoned US20080025924A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance
US11888300 Abandoned US20080031910A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance
US11888285 Abandoned US20080026021A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance
US11888297 Abandoned US20080025923A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance
US11888298 Abandoned US20080025928A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance
US11888147 Abandoned US20080025927A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance

Family Applications Before (13)

Application Number Title Priority Date Filing Date
US09196364 Expired - Lifetime US6096328A (en) 1997-06-06 1998-11-19 Delivery system for an oral care substance using a strip of material having low flexural stiffness
US09864772 Abandoned US20020012685A1 (en) 1997-06-06 2001-05-24 Delivery systems for a tooth whitener and methods of using the same
US09864686 Abandoned US20020006388A1 (en) 1997-06-06 2001-05-24 Delivery systems for a tooth whitener
US09681729 Expired - Lifetime US6551579B2 (en) 1997-06-06 2001-05-29 Delivery systems for a tooth whitener
US10410037 Abandoned US20030211056A1 (en) 1997-06-06 2003-04-09 Tooth whitening substances
US11157769 Abandoned US20050238591A1 (en) 1997-06-06 2005-06-21 Tooth whitening substances
US11638844 Abandoned US20070086961A1 (en) 1997-06-06 2006-12-14 Tooth whitening substances
US11824056 Abandoned US20070248634A1 (en) 1997-06-06 2007-06-29 Delivery system for an oral care substance
US11888299 Abandoned US20080025924A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance
US11888300 Abandoned US20080031910A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance
US11888285 Abandoned US20080026021A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance
US11888297 Abandoned US20080025923A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance
US11888298 Abandoned US20080025928A1 (en) 1997-06-06 2007-07-31 Delivery system for an oral care substance

Country Status (1)

Country Link
US (14) US6096328A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019277A1 (en) * 2002-09-11 2005-01-27 The Procter & Gamble Company Tooth whitening products
US20110070560A1 (en) * 2009-09-23 2011-03-24 Paul Hertz Tooth-whitening method
US9554976B2 (en) 2002-09-11 2017-01-31 The Procter & Gamble Company Tooth whitening product

Families Citing this family (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096328A (en) * 1997-06-06 2000-08-01 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US6350438B1 (en) * 1998-02-27 2002-02-26 The Procter & Gamble Company Oral care compositions comprising chlorite and methods
ES2141050B1 (en) * 1998-03-20 2001-01-01 Biocosmetics Sl Dental bleaching composition.
DE69924265T2 (en) * 1998-09-23 2005-08-25 Unilever N.V. Oral care products
US20020018754A1 (en) * 1999-03-15 2002-02-14 Paul Albert Sagel Shapes for tooth whitening strips
DE60002471T2 (en) 1999-07-02 2004-02-19 The Procter & Gamble Company, Cincinnati Compositions for the release of oral care active ingredients comprising organosiloxane resins by use of a carrier strip redetachable
US7632803B2 (en) 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US7592304B2 (en) 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US20070104798A1 (en) 1999-10-04 2007-05-10 S.K. Pharmaceuticals, Inc. Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide
US20040037891A1 (en) * 1999-10-04 2004-02-26 Karagoezian Hampar L. Synergistic antimicrobial ophthalmic and dermatologic preparations containing chlorite and hydrogen peroxide
US6592907B2 (en) * 1999-10-04 2003-07-15 Hampar L. Karagoezian Synergistic antimicrobial ophthalmic and dermatologic preparations containing chlorite and hydrogen peroxide
US20060169949A1 (en) * 2000-02-02 2006-08-03 Speronello Barry K Massive bodies containing free halogen source for producing highly converted thickened solutions of chlorine dioxide
DK1267812T3 (en) 2000-03-17 2009-04-27 Lg Household & Health Care Ltd Patches for teeth whitening
US6689344B2 (en) 2000-03-17 2004-02-10 Lg Household & Healthcare Ltd. Patches for teeth whitening
US7785572B2 (en) 2000-03-17 2010-08-31 Lg Household And Health Care Ltd. Method and device for teeth whitening using a dry type adhesive
US8652446B2 (en) 2000-03-17 2014-02-18 Lg Household & Healthcare Ltd. Apparatus and method for whitening teeth
KR20030005232A (en) 2000-03-23 2003-01-17 덴츠플라이 인터내셔널 인코포레이티드 Tooth whitening material and method of whitening teeth
KR100645269B1 (en) * 2000-06-28 2006-11-15 더 프록터 앤드 갬블 캄파니 Structures and compositions increasing the stability of peroxide actives
US6582708B1 (en) * 2000-06-28 2003-06-24 The Procter & Gamble Company Tooth whitening substance
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US20020110604A1 (en) * 2000-08-11 2002-08-15 Ashni Naturaceuticals, Inc. Composition exhibiting synergistic antioxidant activity
US6461158B1 (en) 2000-08-14 2002-10-08 The Procter & Gamble Company Products and methods that simulate changes in tooth color
US6607382B1 (en) * 2000-09-21 2003-08-19 Align Technology, Inc. Methods and systems for concurrent tooth repositioning and substance delivery
US6343932B1 (en) * 2000-11-13 2002-02-05 Peter E. Wiesel Delivery system for whitening teeth
US6506053B2 (en) * 2000-11-13 2003-01-14 Peter E. Wiesel Systems for treating teeth
US6685923B2 (en) 2001-01-25 2004-02-03 Dentsply Research & Development Corp. Tooth whitening material and method of whitening teeth
US6500408B2 (en) * 2001-01-27 2002-12-31 Jc Technologies, Inc. Enamel-safe tooth bleach and method for use
US6503486B2 (en) * 2001-03-12 2003-01-07 Colgate Palmolive Company Strip for whitening tooth surfaces
US6419906B1 (en) * 2001-03-12 2002-07-16 Colgate Palmolive Company Strip for whitening tooth surfaces
US6514483B2 (en) * 2001-03-12 2003-02-04 Colgate Palmolive Company Strip for whitening tooth surfaces
US20040131561A1 (en) * 2001-03-14 2004-07-08 Mclaughlin Gerald Strips for treating teeth
US6514484B2 (en) * 2001-03-19 2003-02-04 The Procter & Gamble Company Systems for delivering a cosmetic and/or therapeutic active to oral surfaces using an integral carrier
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
EP2277556B1 (en) 2001-05-01 2016-04-20 A. V. Topchiev Institute of Petrochemical Synthesis Two-phase, water-absorbent bioadhesive composition
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
ES2331302T3 (en) 2001-05-01 2009-12-29 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions.
US6746679B2 (en) * 2001-08-02 2004-06-08 Oral Health Clinical Services Llc Tooth whitening hydrogels
JP2004538085A (en) * 2001-08-17 2004-12-24 スミスクライン ビーチャム パブリック リミテッド カンパニーSmithKline Beecham p.l.c. Oral care substance delivery strip
US6783767B2 (en) 2002-02-08 2004-08-31 Healthpoint, Ltd. Low temperature disinfectant/sterilant for medical devices and topical applications
US6949240B2 (en) * 2002-05-23 2005-09-27 The Procter & Gamble Company Tooth whitening products
JP2004018470A (en) * 2002-06-18 2004-01-22 Takasago Internatl Corp Antimicrobial perfume composition, foul breath-preventing perfume composition, and composition for oral cavity containing the compositions
US20040131558A1 (en) * 2002-06-21 2004-07-08 Hauck Douglas J. Oral disease prevention and treatment
US20040131559A1 (en) * 2002-11-04 2004-07-08 Hauck Douglas J. Oral disease prevention and treatment
US20040157192A1 (en) 2002-06-28 2004-08-12 Scott Jacobs Teeth treatment device
US8956160B2 (en) * 2002-07-02 2015-02-17 Ranir, Llc Device and method for delivering an oral care agent
US6787675B2 (en) 2002-07-29 2004-09-07 Warner-Lambert Company Substituted tropolone compounds, oral care compositions containing the same and methods of using the same
US6689342B1 (en) 2002-07-29 2004-02-10 Warner-Lambert Company Oral care compositions comprising tropolone compounds and essential oils and methods of using the same
EP1393710A1 (en) * 2002-08-21 2004-03-03 THE PROCTER & GAMBLE COMPANY A method of applying an oral composition
US20040120903A1 (en) 2002-09-11 2004-06-24 The Procter & Gamble Company Tooth whitening strips
US20050100515A1 (en) * 2002-09-11 2005-05-12 The Procter & Gamble Company Tooth whitening products
US6916463B2 (en) * 2002-09-24 2005-07-12 The Procter & Gamble Company Oral products having an aesthetic layer
US7008620B2 (en) * 2002-09-30 2006-03-07 Johnson & Johnson Consumer Companies, Inc. Depilatory compositions and articles and the use thereof
US20040062798A1 (en) * 2002-09-30 2004-04-01 Lukenbach Elvin R. Exothermic article and the use thereof in whitening teeth
US20040063603A1 (en) * 2002-09-30 2004-04-01 Vipul Dave Exothermic article and the use thereof
US20040096569A1 (en) * 2002-11-15 2004-05-20 Barkalow David G. Edible film products and methods of making same
US20040111275A1 (en) * 2002-11-15 2004-06-10 Kroll David B. Methods for marketing and generating revenue from edible thin films
US6860736B2 (en) * 2003-05-23 2005-03-01 Ultradent Products, Inc. Oral treatment devices that include a thin, flexible barrier layer and an endoskeleton treatment or adhesive composition
US7004756B2 (en) * 2003-01-24 2006-02-28 Ultradent Products, Inc. Pre-shaped dental trays and treatment devices and methods that utilize such dental trays
US6964571B2 (en) * 2003-01-24 2005-11-15 Ultradent Products, Inc. Pre-shaped dental trays and treatment devices and methods that utilize such dental trays
US20040156794A1 (en) * 2003-02-11 2004-08-12 Barkalow David G. Bioerodible and bioadhesive confectionery products and methods of making same
US6840771B1 (en) 2003-04-25 2005-01-11 Eugene C. Wagner Tooth whitening appliance
US7114953B1 (en) 2003-04-25 2006-10-03 Wagner Eugene C Tooth whitening appliance having membrane covered applicator
EP1620066A4 (en) * 2003-05-07 2010-11-03 Dmi Biosciences Inc Oral care methods and products
US7040897B2 (en) * 2003-05-23 2006-05-09 Ultradent Products, Inc. Thin, flexible membrane dental trays and systems and methods utilizing such trays
US7056118B2 (en) * 2003-05-27 2006-06-06 Ultradent Products, Inc. Compositions and devices having a tray-like configuration for delivering a medicament and methods of manufacturing and using such compositions and devices
US7052275B2 (en) * 2003-05-27 2006-05-30 Ultradent Products, Inc. Kits and methods for bleaching and desensitizing teeth
US7059857B2 (en) * 2003-05-27 2006-06-13 Ultradent Products, Inc. Substantially solid desensitizing compositions and devices having a tray-like configuration and methods of manufacturing and using such compositions and devices
US7048543B2 (en) * 2003-05-27 2006-05-23 Ultradent Products, Inc. Substantially solid bleaching composition in a tray-like configuration
US7074042B2 (en) * 2003-05-27 2006-07-11 Ultradent Products, Inc. Tray-like dental bleaching devices having a barrier layer and a substantially solid bleaching composition
US20040241294A1 (en) * 2003-05-31 2004-12-02 Barabolak Roman M. Edible films including aspartame and methods of making same
US20050002975A1 (en) * 2003-06-06 2005-01-06 Densen Cao Structures and methods for delivering topical compositions
US20050036958A1 (en) * 2003-08-13 2005-02-17 Jianxun Feng Dental bleaching
CN102188335A (en) * 2003-10-14 2011-09-21 高露洁-棕榄公司 Tooth whitening composition
US6981874B2 (en) * 2003-10-22 2006-01-03 Ultradent Products, Inc. Dental bleaching compositions and devices having a solid activation adhesive layer or region and bleaching gel layer or region
US6997708B2 (en) * 2003-10-22 2006-02-14 Ultradent Products, Inc. Treatment compositions and strips having a solid adhesive layer and treatment gel adjacent thereto
US7011523B2 (en) * 2003-10-22 2006-03-14 Ultradent Products, Inc. Bleaching compositions and devices having a solid adhesive layer and bleaching gel adjacent thereto
US20050118115A1 (en) * 2003-10-24 2005-06-02 Fontenot Mark G. Accelerated tooth whitening method, composition and kit
US20050143274A1 (en) 2003-12-17 2005-06-30 Ghosh Chanchal K. Compositions and methods of delivering bleaching agents to teeth
CN1929819B (en) 2004-01-30 2012-02-29 A.V.石化合成托普契夫研究所 Rapidly dissolving film for delivery of an active agent
US7059858B2 (en) * 2004-02-19 2006-06-13 Ultradent Products, Inc. Universal tray design having anatomical features to enhance fit
US7192280B2 (en) * 2004-02-19 2007-03-20 Ultradent Products, Inc. Dental bleaching devices having a protective adhesive region
US20050196348A1 (en) * 2004-03-03 2005-09-08 Constantine Georgiades Stabilized peroxide compositions
US20070190125A1 (en) * 2004-03-03 2007-08-16 Constantine Georgiades Positioning feature for aiding use of film or strip product
US20070269519A1 (en) * 2004-03-03 2007-11-22 Constantine Georgiades Whitening products
US20080003248A1 (en) * 2004-03-03 2008-01-03 Constantine Georgiades Whitening products
US20050196354A1 (en) * 2004-03-03 2005-09-08 Andre Soshinsky Film compositions
US20050196355A1 (en) * 2004-03-03 2005-09-08 Constantine Georgiades Film products having controlled disintegration properties
DE102004011557A1 (en) * 2004-03-08 2005-09-29 Henkel Kgaa Bleach and applicators for teeth
US20050260142A1 (en) * 2004-04-28 2005-11-24 Philp Graham K Jr Method for tooth whitening, in particular a system for tooth whitening using a phase transfer catalyst (PTC)
US20050255054A1 (en) * 2004-04-30 2005-11-17 Philp Graham K Jr Method for tooth whitening, in particular a system for tooth whitening using a dissolvable tray or strip
US7264471B2 (en) 2004-05-05 2007-09-04 Ultradent Products, Inc. Methods and kits for bleaching teeth while protecting adjacent gingival tissue
CA2470463C (en) * 2004-06-09 2012-09-18 Lornamead Brands, Inc. Tooth whitening products and methods of making the same
US20050281757A1 (en) * 2004-06-17 2005-12-22 Sayed Ibrahim Oral care film
US20060008767A1 (en) * 2004-07-09 2006-01-12 The Procter & Gamble Company Oral care devices
EP1791575B1 (en) 2004-08-05 2014-10-08 Corium International, Inc. Adhesive composition
US7625210B2 (en) * 2004-08-09 2009-12-01 Ultradent Products, Inc. Treatment devices for providing oral treatments and kits and methods that utilize such treatment devices
US20060034784A1 (en) * 2004-08-12 2006-02-16 The Procter & Gamble Company Oral compositions and systems
US20080220088A1 (en) * 2004-10-07 2008-09-11 Ngen Pharmaceuticals N.V. Composition for Treating Wounds and Burns
US20060099550A1 (en) * 2004-11-10 2006-05-11 Ranir/Dcp Corporation Device and method for delivering an oral care agent
DE102004061646A1 (en) * 2004-12-17 2006-07-20 S&C Polymer Silicon- und Composite-Spezialitäten GmbH Tooth bleaching
US20060141416A1 (en) * 2004-12-24 2006-06-29 Knutson Eric J Occlusal indicator tray & processes therefor
US20060147394A1 (en) * 2004-12-30 2006-07-06 Ramachandra Shastry Tooth whitening composition containing cross-linked polymer-peroxides
US7247022B2 (en) * 2005-01-31 2007-07-24 Ultradent Products, Inc. Dental tray system with releasable hold inner and outer dental trays
US20060171905A1 (en) * 2005-01-31 2006-08-03 Allred Peter M Dental bleaching compositions having a protective coating applied thereto
GB0502046D0 (en) * 2005-02-01 2005-03-09 Sinclair Pharmaceuticals Ltd Method
US20060228307A1 (en) * 2005-04-08 2006-10-12 Cao Group, Inc. Structures and methods for delivering topical compositions
US8956162B2 (en) 2005-04-11 2015-02-17 Sylphar N.V. Strip for the delivery of oral care compositions
US8753612B2 (en) * 2005-04-11 2014-06-17 Sylphar Nv Foam strip for the delivery of oral care compositions
EP2700396A3 (en) 2012-06-20 2015-04-29 Sylphar Nv Strip for the delivery of oral care compositions
US7452209B2 (en) * 2005-05-02 2008-11-18 Ultradent Products, Inc. Exoskeleton support for placement of a dental treatment strip
EP1733710A1 (en) 2005-06-17 2006-12-20 The Procter & Gamble Company Cohesive emulsion composition comprising a bleaching agent
US20060292090A1 (en) * 2005-06-22 2006-12-28 Deepak Sharma Oral care compositions, devices, and methods of using the same
US8414293B2 (en) * 2005-06-28 2013-04-09 Colgate-Palmolive Company Carrier strip for application to oral surfaces and related methods
US8137658B2 (en) 2005-06-28 2012-03-20 Isp Investments Inc. Tooth whitening compositions
US20070071817A1 (en) * 2005-09-26 2007-03-29 Phyzz, Inc. Effervescent oral care compositions and method of use
US20070099812A1 (en) * 2005-10-27 2007-05-03 Luizzi Joseph M Exothermic cleansing article
US20070099813A1 (en) * 2005-10-27 2007-05-03 Luizzi Joseph M Effervescent cleansing article
US20070172412A1 (en) * 2006-01-26 2007-07-26 Linda Hratko Thickened fluid composition comprising chlorine dioxide
GB0604018D0 (en) * 2006-02-28 2006-04-05 Sinclair Pharmaceuticals Ltd Method
EP2004134A2 (en) * 2006-04-07 2008-12-24 The Procter and Gamble Company Oral care regimens and kits
US20070264226A1 (en) * 2006-05-10 2007-11-15 Karagoezian Hampar L Synergistically enhanced disinfecting solutions
US20100015068A1 (en) * 2006-07-06 2010-01-21 Massachusetts Institute Of Technology Methods and Compositions For Altering Biological Surfaces
WO2008021088A3 (en) * 2006-08-08 2008-12-24 Alan M Fogelman Salicylanilides enhance oral delivery of therapeutic peptides
US20080044796A1 (en) * 2006-08-18 2008-02-21 Beyond Technology Corp. A teeth whitening system and a method for whitening teeth
WO2008024219A3 (en) * 2006-08-21 2008-04-17 Creative Specialty Products Ll Dental whitening strip
US8007277B2 (en) 2006-08-25 2011-08-30 Ultradent Products, Inc. Non-custom dental treatment trays and mouth guards having improved anatomical features
WO2008045076A1 (en) * 2006-10-12 2008-04-17 Dentovations Inc. Moldable tray, system, and method for whitening teeth
US8795636B2 (en) * 2006-11-17 2014-08-05 Jasibo, LLC. Tooth whitener and maintenance with bleach bumpers
US8202091B2 (en) * 2007-08-31 2012-06-19 Ultradent Products, Inc. Dental treatment trays comprising silicone elastomeric material
US20090087812A1 (en) * 2007-10-02 2009-04-02 Ultradent Products, Inc. Self-customizable dental treatment trays
US20090208543A1 (en) * 2008-01-22 2009-08-20 Oral Health Clinical Services Method and apparatus for applying a protective oral care composition
DE102008014533A1 (en) * 2008-03-15 2009-09-17 Lts Lohmann Therapie-Systeme Ag Gingival wafer
US8282298B2 (en) 2008-06-26 2012-10-09 Colgate-Palmolive Company Oral care implement
US20100012894A1 (en) * 2008-07-15 2010-01-21 Basf Catalysts Llc Tooth Whitening Compositions and Methods
KR20110039461A (en) * 2008-07-15 2011-04-18 바스프 코포레이션 Methods, systems and devices for administration of chlorine dioxide
US20100015252A1 (en) * 2008-07-15 2010-01-21 Basf Catalysts Llc Tooth Polishing Compositions and Methods of Tooth Polishing Without Mechanical Abrasion
US20100028829A1 (en) * 2008-07-31 2010-02-04 Ultradent Products, Inc. Chemically activated dental bleaching trays
EP2387394B1 (en) 2009-01-14 2018-05-02 Corium International, Inc. Transdermal administration of tamsulosin
US20100196512A1 (en) * 2009-02-04 2010-08-05 Basf Catalyst Llc Treatment of Non-Oral Biological Tissue with Chlorine Dioxide
US9211988B2 (en) * 2009-09-18 2015-12-15 Cao Group, Inc. Packaging for gummy substratum
WO2011094657A3 (en) 2010-01-31 2011-12-01 Basf Corporation Additives for chlorine dioxide-containing compositions
US20110315151A1 (en) * 2010-06-28 2011-12-29 Kristin Annette Schabert Orthodontic Pain Shield
US20120107768A1 (en) * 2010-10-29 2012-05-03 Diedwardo William A Dental protective device and method of use
US9648874B2 (en) 2010-12-07 2017-05-16 Kimberly-Clark Worldwide, Inc. Natural, multiple use and re-use, user saturated wipes
US8445032B2 (en) 2010-12-07 2013-05-21 Kimberly-Clark Worldwide, Inc. Melt-blended protein composition
US9832993B2 (en) 2010-12-07 2017-12-05 Kimberly-Clark Worldwide, Inc. Melt processed antimicrobial composition
US8524264B2 (en) 2010-12-07 2013-09-03 Kimberly-Clark Worldwide, Inc. Protein stabilized antimicrobial composition formed by melt processing
US9149045B2 (en) 2010-12-07 2015-10-06 Kimberly-Clark Worldwide, Inc. Wipe coated with a botanical emulsion having antimicrobial properties
US20120147342A1 (en) * 2010-12-14 2012-06-14 National Chiao Tung University Projection apparatus
US8936026B2 (en) 2011-02-08 2015-01-20 Orvance Technologies, Llc Orthodontic appliance shield
KR101328162B1 (en) * 2011-06-27 2013-11-13 조선대학교산학협력단 fluorine agent of tape type using biodegradable polymers and manufacturing method thereof
US8574628B2 (en) 2011-12-19 2013-11-05 Kimberly-Clark Worldwide, Inc. Natural, multiple release and re-use compositions
JP6181666B2 (en) 2011-12-19 2017-08-16 コルゲート・パーモリブ・カンパニーColgate−Palmolive Company Peracid - product composition
US8728447B2 (en) * 2012-02-17 2014-05-20 Far Eastern New Century Corporation Teeth-whitening gel
CN103301031A (en) * 2012-03-06 2013-09-18 远东新世纪股份有限公司 Tooth whitening gel
US8721328B2 (en) 2012-07-03 2014-05-13 Toothfilm Biotech Innovation Co., Ltd. Patch for oral health care
JP2016502415A (en) 2012-10-17 2016-01-28 ザ プロクター アンド ギャンブルカンパニー The method for applying the strip and oral care actives for delivery of oral care actives
EP3315120A1 (en) 2016-10-26 2018-05-02 The Procter and Gamble Company Oral composition for tooth whitening
EP3315117A1 (en) 2016-10-26 2018-05-02 The Procter and Gamble Company Oral composition for delivering oral care active agents
EP3315118A1 (en) 2016-10-26 2018-05-02 The Procter and Gamble Company Kit for tooth whitening comprising an oral composition and a delivery carrier
WO2018080991A1 (en) 2016-10-26 2018-05-03 The Procter & Gamble Company Tooth whitening
EP3315173A1 (en) 2016-10-26 2018-05-02 The Procter and Gamble Company Kit for tooth whitening comprising a multi-phase oral composition and an electromagnetic radiation source
EP3315172A1 (en) 2016-10-26 2018-05-02 The Procter and Gamble Company Multi-phase oral composition for tooth whitening
EP3315119A1 (en) 2016-10-26 2018-05-02 The Procter and Gamble Company Kit for tooth whitening comprising an oral composition, a delivery carrier and an electromagnetic radiation source
EP3315171A1 (en) 2016-10-26 2018-05-02 The Procter and Gamble Company Kit for tooth whitening comprising an oral composition and an electromagnetic radiation source

Citations (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US533076A (en) * 1895-01-29 Mechanical movement
US2835628A (en) * 1957-04-01 1958-05-20 Jacob A Saffir Means for treating teeth
US3256014A (en) * 1963-04-05 1966-06-14 Technical Displays Inc Display device with two rheostats
US3444858A (en) * 1965-05-14 1969-05-20 Higham S Russell Method and means for administering drugs
US3640741A (en) * 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3657413A (en) * 1969-08-28 1972-04-18 Block Drug Co Antiseptic composition containing peroxide glycerol and carboxypolymethylene polymer
US3659928A (en) * 1969-05-12 1972-05-02 John Alan Davis Reflection apparatus for simulating the effect of use by a person of a cosmetic or article
US3711182A (en) * 1971-05-17 1973-01-16 J Jasgur Glareless mirror using relatively rotatable polarizers
US3729839A (en) * 1971-12-30 1973-05-01 J Bourdier Installation for trying on wearing apparel and accessories
US3784390A (en) * 1971-07-23 1974-01-08 Hayashibara Biochem Lab Shaped bodies of pullulan and their use
US3859987A (en) * 1972-04-17 1975-01-14 Harald Holstad Mirror, particularly for examination of cavities, for example, surgical mirrors or dental mirrors
US3955281A (en) * 1974-12-05 1976-05-11 Pacemaker Corporation Disposable dental tray for topical application of fluoride gel and other dental medications
US3964164A (en) * 1973-02-05 1976-06-22 Hesselgren Sven Gunnar Method of applying preventive and therapeutic agents
US4029758A (en) * 1975-12-15 1977-06-14 Hoffmann-La Roche Inc. Preparation of pharmaceutical unit dosage forms
US4029757A (en) * 1975-12-15 1977-06-14 Hoffmann-La Roche Inc. Manufacture of pharmaceutical unit dosage forms
US4031200A (en) * 1975-12-15 1977-06-21 Hoffmann-La Roche Inc. Manufacture of pharmaceutical unit dosage forms
US4032627A (en) * 1973-04-02 1977-06-28 Koh-I-Noor Rapidograph, Inc. Tooth whitening cosmetic composition
US4072551A (en) * 1975-12-15 1978-02-07 Hoffman-La Roche Inc. Novel dosage form
US4084700A (en) * 1976-02-06 1978-04-18 Optarac Corporation Display rack
US4136145A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US4136162A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US4138314A (en) * 1975-04-10 1979-02-06 Basf Wyandotte Corporation Method of forming diaphragms from discrete thermoplastic fibers requiring no bonding or cementing
US4139627A (en) * 1977-10-06 1979-02-13 Beecham Inc. Anesthetic lozenges
US4138814A (en) * 1976-03-08 1979-02-13 Pacemaker Corporation Disposable dental tray for topical application of fluoride gel and other dental medications
US4182222A (en) * 1978-02-16 1980-01-08 Stahl Robert L Coupon confining bag method
US4251400A (en) * 1971-11-03 1981-02-17 Borden, Inc. Hot and cold water redispersible polyvinyl acetate adhesives
US4273418A (en) * 1979-11-30 1981-06-16 Wham-O Mfg. Co. Mirror for producing optical illusions
US4324547A (en) * 1978-09-16 1982-04-13 Vishay Intertechnology, Inc. Dentistry technique
US4325855A (en) * 1975-09-10 1982-04-20 Lingner And Fischer Gmbh Adhesives
US4331576A (en) * 1981-01-29 1982-05-25 Herman Colon Water-soluble, pressure-sensitive, hot-melt adhesives
US4335731A (en) * 1978-07-25 1982-06-22 Bora Jr F William Device for oral hygiene care
US4373036A (en) * 1981-12-21 1983-02-08 Block Drug Company, Inc. Denture fixative composition
US4376628A (en) * 1979-05-09 1983-03-15 B.V. Gaba Device for treating teeth
US4428373A (en) * 1982-02-03 1984-01-31 Sultan Dental Products Limited Disposable dental tray
US4431631A (en) * 1983-01-03 1984-02-14 Colgate-Palmolive Company Aqueous oral solution
US4438258A (en) * 1981-06-12 1984-03-20 National Research Development Corporation Hydrogels
US4442258A (en) * 1979-07-04 1984-04-10 Nitto Electric Industrial Co., Ltd. Water-soluble pressure-sensitive adhesive composition
US4503070A (en) * 1981-07-31 1985-03-05 Eby Iii George A Method for reducing the duration of the common cold
US4515162A (en) * 1980-03-14 1985-05-07 Nitto Electric Industrial Co., Ltd. Electrode pad
US4517173A (en) * 1980-09-26 1985-05-14 Nippon Soda Co. Ltd. Mucous membrane-adhering film preparation and process for its preparation
US4518721A (en) * 1982-03-26 1985-05-21 Richardson-Vicks Inc. Hydrophilic denture adhesive
US4522806A (en) * 1980-10-10 1985-06-11 Lever Brothers Company Oral compositions for hexetidine and zinc salts for the synergistic inhibition of dental plaque
US4522805A (en) * 1983-06-08 1985-06-11 Norman Gordon Tooth and gum dentifrice
US4522593A (en) * 1983-07-07 1985-06-11 Fischer Dan E Knitted gingival retraction cord
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4592487A (en) * 1985-07-03 1986-06-03 Simon Gilbert I Dentifrices
US4593053A (en) * 1984-12-07 1986-06-03 Medtronic, Inc. Hydrophilic pressure sensitive biomedical adhesive composition
US4592726A (en) * 1983-01-03 1986-06-03 Herbert Brilliant Diagnostic mirror and light filter
US4592488A (en) * 1985-05-24 1986-06-03 Simon Gilbert I Method for the preparation of chemotherapeutic compositions for the treatment of periodontal disease, compositions therefor and use thereof
US4640685A (en) * 1985-04-15 1987-02-03 Croll Theodore P Hand-held light filter
US4650665A (en) * 1985-02-08 1987-03-17 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4661070A (en) * 1986-03-17 1987-04-28 Joshua Friedman Method for bleaching discolored teeth
US4722761A (en) * 1986-03-28 1988-02-02 Baxter Travenol Laboratories, Inc. Method of making a medical electrode
US4728291A (en) * 1986-06-26 1988-03-01 Golub Jeff E Cloth wrap dental process
US4741700A (en) * 1986-07-16 1988-05-03 Barabe David J Dental breath freshening device
US4741941A (en) * 1985-11-04 1988-05-03 Kimberly-Clark Corporation Nonwoven web with projections
US4799888A (en) * 1986-06-26 1989-01-24 Golub Jeff E Dental process with treated fabric
US4812308A (en) * 1987-02-20 1989-03-14 Church & Dwight Co., Inc. Hydrogen peroxide-releasing tooth powder
US4828113A (en) * 1988-05-18 1989-05-09 Friedland Jeffrey B Dental treatment kit
US4837008A (en) * 1985-04-09 1989-06-06 Peroxydent Group Periodontal composition and method
US4839156A (en) * 1987-04-17 1989-06-13 Colgate-Palmolive Company Stable hydrogen peroxide dental gel
US4839157A (en) * 1987-04-17 1989-06-13 Colgate-Palmolive Company Stable hydrogen peroxide dental gel containing fumed silicas
US4895517A (en) * 1987-04-14 1990-01-23 Ultradent Products, Inc. Methods for performing vital dental pulpotomy
US4895721A (en) * 1988-01-22 1990-01-23 Carter-Wallace Inc. Peroxide gel dentifrice compositions
US4900554A (en) * 1986-12-24 1990-02-13 Teikoku Seiyaku Co., Ltd. Adhesive device for application to body tissue
US4900552A (en) * 1988-03-30 1990-02-13 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
US4900253A (en) * 1987-07-15 1990-02-13 Landis Timothy J Dental mirror having ultraviolet filter
US4902227A (en) * 1988-05-04 1990-02-20 Pascal Company, Inc. Dental treatment tray
US4910247A (en) * 1989-03-27 1990-03-20 Gaf Chemicals Corporation Adhesive composition
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
US4919615A (en) * 1989-04-28 1990-04-24 Croll Theodore P Orthodontic band cap
US4927634A (en) * 1987-12-16 1990-05-22 Richardson-Vicks Inc. Pharmaceutical compositions containing dyclonine HC1 and phenol
US4927636A (en) * 1986-11-11 1990-05-22 501 Kabushiki Kaisha Hayashibara Kagaku Kenkyujo Association complex comprising pullulan and polyethylene glycol, and preparation and uses of the same
US4931282A (en) * 1987-11-25 1990-06-05 Minnesota Mining And Manufacturing Company Pressure-sensitive medical sealant
US4983379A (en) * 1983-03-01 1991-01-08 Schaeffer Hans A Dental preparation, article and method for storage and delivery thereof
US4983381A (en) * 1985-12-30 1991-01-08 Futura Medical S.A. Method and device for producing the whitening of live teeth with pathological and normal colorations
US4988500A (en) * 1989-09-29 1991-01-29 The Procter & Gamble Company Oral compositions
US4990089A (en) * 1988-08-23 1991-02-05 Dunhall Pharmaceuticals, Inc. Method and material for brightening teeth
US5001170A (en) * 1989-12-01 1991-03-19 Warner-Lambert Company Denture stabilizer
US5024701A (en) * 1983-08-01 1991-06-18 Hercules Incorporated Denture adhesive composition
US5084268A (en) * 1991-06-17 1992-01-28 Dental Concepts, Inc. Tooth whitening dentifrice
US5098303A (en) * 1990-03-22 1992-03-24 Ultradent Products, Inc. Method for bleaching teeth
US5186938A (en) * 1984-07-24 1993-02-16 Key Pharmaceuticals, Inc. Adhesive transdermal dosage layer
US5192802A (en) * 1991-09-25 1993-03-09 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
US5211559A (en) * 1991-07-18 1993-05-18 Gillette Canada Inc. Dental treatment tray for holding medicament gel
US5288231A (en) * 1993-03-08 1994-02-22 Pinnacle Products, Inc. Light shield for dental apparatus
US5288498A (en) * 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
US5290566A (en) * 1990-12-18 1994-03-01 Schow Robert S Tooth whitening formulation and method
US5310563A (en) * 1991-10-25 1994-05-10 Colgate-Palmolive Company Dental material and method for applying preventative and therapeutic agents
US5380198A (en) * 1990-08-06 1995-01-10 Suhonen; Jouko Matrix for dental medicine and a device for the fabricaton of matrix bands
US5387103A (en) * 1993-02-16 1995-02-07 Ultradent Products, Inc. Syringe apparatus for delivering tooth composites and other solid yet pliable materials
US5393528A (en) * 1992-05-07 1995-02-28 Staab; Robert J. Dissolvable device for contraception or delivery of medication
US5401495A (en) * 1990-10-10 1995-03-28 Natural White, Inc. Teeth whitener
US5401528A (en) * 1991-03-19 1995-03-28 Thera Patent GmbH & Co. KG Geselleschaft fur industrielle Schutzrechte Use of compositions based on organically modified silicic acid polycondensates for coating teeth and dental prostheses
US5505933A (en) * 1994-06-27 1996-04-09 Colgate Palmolive Company Desensitizing anti-tartar dentifrice
US5509800A (en) * 1993-08-20 1996-04-23 Cunningham; Peter J Light-filter for dental use
US5599553A (en) * 1992-09-01 1997-02-04 Dong Kook Pharmaceutical Co., Ltd. Local drug delivery film for periodontal treatment

Family Cites Families (222)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US33093A (en) * 1861-08-20 Improvement in potato-diggers
US2991229A (en) * 1958-09-30 1961-07-04 Union Carbide Corp Toothpaste composition
DE1104116B (en) * 1959-02-05 1961-04-06 Dr Rudolf Eisenhut Auxiliary strip to hold the stuffing in the plumbing of teeth
US3070102A (en) 1960-05-12 1962-12-25 Harold B Macdonald Throw-away toothbrush and package
US3096202A (en) * 1960-08-30 1963-07-02 Johnson & Johnson Polyvinyl pyrrolidone pressure sensitive adhestive and tape containing same
US3998215A (en) * 1968-12-18 1976-12-21 Minnesota Mining And Manufacturing Company Bio-medical electrode conductive gel pads
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3625215A (en) 1970-07-09 1971-12-07 Sverre Quisling Dental sheaths
US3688406A (en) * 1970-08-07 1972-09-05 William I Porter Apparatus for and method of applying decay retardant compositions to teeth
US3754332A (en) * 1970-09-09 1973-08-28 L Warren Treatment member
US3711183A (en) * 1971-05-19 1973-01-16 Honney Toy Ind An optical toy device for simulating stereoscopic x-ray images
US3902509A (en) 1972-10-10 1975-09-02 Colgate Palmolive Co Disposable device for cleaning teeth
DE2330869C2 (en) * 1973-06-16 1982-10-28 Gerd 6070 Langen De Hanel
US3844286A (en) 1973-08-10 1974-10-29 Chemed Corp Releasable medicament dental carrier and method
US3954962A (en) * 1974-04-01 1976-05-04 Alan R. Tripp Oral hygiene product
US3972995A (en) 1975-04-14 1976-08-03 American Home Products Corporation Dosage form
JPS5729448B2 (en) * 1978-11-06 1982-06-23
DE2966275D1 (en) * 1978-11-07 1983-11-10 Beecham Group Plc Device for oral administration to a ruminant animal
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4211330A (en) 1979-02-01 1980-07-08 Strock Alvin E Oral health and hygiene kit
US4363843A (en) 1979-03-20 1982-12-14 Raychem Limited Seals
US4713239A (en) * 1979-05-29 1987-12-15 Vsesojuny Kardiologichesky Nauchny Tsentr Adkaemii Meditsinski Nauk Sssr Antianginal film and method of treating ischemic heart disease
US4307075A (en) * 1979-09-13 1981-12-22 American Home Products Corporation Topical treatment of aphthous stomatitis
EP0062052A4 (en) * 1980-10-03 1984-03-27 Andras Sugar Composition used for dental cosmetics.
US4557692A (en) 1981-02-12 1985-12-10 Chorbajian Peter M Occlusal splints and the method of manufacturing the same
DE3237945A1 (en) * 1981-10-20 1983-05-05 Sandoz Ag Pharmaceutical compositions with sustained release
US4460562A (en) * 1982-01-06 1984-07-17 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing propranolol
US4537778A (en) 1983-01-03 1985-08-27 Colgate-Palmolive Company Oral preparation
US4528180A (en) 1983-03-01 1985-07-09 Schaeffer Hans A Dental preparation, article and method for storage and delivery thereof
US4849213A (en) 1983-03-01 1989-07-18 Schaeffer Hans A Dental preparation, article and method for storage and delivery therof
US4687663B1 (en) 1983-03-01 1997-10-07 Chesebrough Ponds Usa Co Dental preparation article and method for storage and delivery thereof
US4554154A (en) 1983-03-15 1985-11-19 White Maurice J E Dental product and method of dental treatment
US4532063A (en) * 1983-08-15 1985-07-30 S. C. Johnson & Son, Inc. Dissolvable bleach sheet
US4971782A (en) 1983-09-14 1990-11-20 Peroxydent Group Periodontal composition and method
JPH0549705B2 (en) * 1984-04-14 1993-07-27 Hayashibara Biochem Lab
US5625979A (en) * 1992-09-04 1997-05-06 Southpac Trust International, Inc. Sleeve having a detachable portion forming a skirt and methods
US4560351A (en) 1984-07-05 1985-12-24 Osborne Travis H Method of and apparatus for applying dental treatment fluid
US4544354A (en) 1984-09-21 1985-10-01 Gores Kenneth W Anteriorly bridged dental trays
JPH0522685B2 (en) * 1984-10-04 1993-03-30 Teikoku Seiyaku Kk
EP0200508B1 (en) 1985-04-27 1991-10-02 Nitto Denko Corporation Adhesive oral bandages and oral pharmaceutical preparations
DE3524572A1 (en) 1985-07-10 1987-01-15 Thomae Gmbh Dr K Solid pharmaceutical preparations for oral application containing 9-deoxo-11-deoxy-9,11- (imino (2- (2-methoxyethoxy) ethylidene) oxy) - (9S) -erythromycin, and processes for their preparation
US4690996A (en) * 1985-08-28 1987-09-01 National Starch And Chemical Corporation Inverse emulsions
US4965109A (en) * 1987-03-09 1990-10-23 First Brands Corporation Low temperature impact and puncture resistant polypropyene films layered films and bags therefrom
WO1987002241A1 (en) * 1985-10-09 1987-04-23 Desitin Arzneimittel Gmbh Process for producing an administration or dosage form of drugs, reagents or other active ingredients
US4712460A (en) * 1985-11-18 1987-12-15 Biotrack, Inc. Integrated drug dosage form and metering system
US5229164A (en) * 1985-12-19 1993-07-20 Capsoid Pharma Gmbh Process for producing individually dosed administration forms
US4755386A (en) 1986-01-22 1988-07-05 Schering Corporation Buccal formulation
JPH0729915B2 (en) * 1986-02-01 1995-04-05 帝國製薬株式会社 Sheet - door-like buccal adhesive agent
US4770634A (en) 1986-06-11 1988-09-13 Pellico Michael A Method for treating teeth with foamable fluoride compositions
USRE33093E (en) 1986-06-16 1989-10-17 Johnson & Johnson Consumer Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
US4696757A (en) 1986-06-16 1987-09-29 American Home Products Corporation Stable hydrogen peroxide gels
US4713243A (en) * 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
EP0252459A1 (en) 1986-07-07 1988-01-13 Schering Corporation Compartmentalized transdermal delivery system
JPH062671B2 (en) * 1986-08-25 1994-01-12 サンスタ−株式会社 Intra-oral formulation
DE3630603C2 (en) * 1986-09-09 1989-06-22 Desitin Arzneimittel Gmbh, 2000 Hamburg, De
US4786253A (en) * 1986-12-04 1988-11-22 Henneret Properties (Proprietary) Limited Dental model articulator
US4860754A (en) * 1987-04-01 1989-08-29 E. R. Squibb & Sons, Inc. Electrically conductive adhesive materials
US4788052A (en) 1987-04-17 1988-11-29 Colgate-Palmolive Company Stable hydrogen peroxide dental gel containing fumed silicas
US4980152A (en) 1987-08-06 1990-12-25 Marion Laboratories Oral preparation
CA2000040C (en) 1987-08-07 1995-10-03 Skip Berg Disposable tooth cleaning and polishing apparatus
EP0303445A1 (en) * 1987-08-13 1989-02-15 Walton S.A. Clebopride transdermal patch
US5059189A (en) * 1987-09-08 1991-10-22 E. R. Squibb & Sons, Inc. Method of preparing adhesive dressings containing a pharmaceutically active ingredient
US5160737A (en) * 1988-05-03 1992-11-03 Perio Products Ltd. Liquid polymer composition, and method of use
US5330746A (en) * 1988-05-03 1994-07-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Dental varnish composition, and method of use
US5438076A (en) * 1988-05-03 1995-08-01 Perio Products, Ltd. Liquid polymer composition, and method of use
US5047244A (en) * 1988-06-03 1991-09-10 Watson Laboratories, Inc. Mucoadhesive carrier for delivery of therapeutical agent
DE3827561C1 (en) * 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
USRE34196E (en) 1988-08-23 1993-03-16 Dunhall Pharmaceuticals, Inc. Method and material for brightening teeth
DE68904539T2 (en) * 1988-11-28 1993-06-03 Unilever Nv Dentifrices, the aminoalkyl silicones included.
US4948580A (en) * 1988-12-08 1990-08-14 E. R. Squibb & Sons, Inc. Muco-bioadhesive composition
JPH0645536B2 (en) * 1989-01-31 1994-06-15 サンスター株式会社 Oral mucosal patch and oral mucosa adhesive preparation
JP2656338B2 (en) 1989-01-31 1997-09-24 日東電工株式会社 Oral mucosal patch preparation
WO1990009165A1 (en) 1989-02-15 1990-08-23 Murayama Ronald K Teeth whitener
US5064717A (en) * 1989-04-28 1991-11-12 Kanzaki Paper Manufacturing Co., Ltd. Adhesive sheet
US4968251A (en) 1989-07-03 1990-11-06 Darnell Daniel H Treatment of a tooth
US5356291A (en) 1989-07-03 1994-10-18 Dunhall Pharmaceuticals, Inc. Treatment of a tooth
ES2044227T3 (en) * 1989-07-13 1994-01-01 Oskar Altwirth daentales adhesive insert for dentures and method for its manufacture.
US5252334A (en) * 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
US5271940A (en) * 1989-09-14 1993-12-21 Cygnus Therapeutic Systems Transdermal delivery device having delayed onset
US4972946A (en) 1990-01-08 1990-11-27 Dale Whittaker Disposable dental hygiene kit
US5234342A (en) * 1990-03-22 1993-08-10 Ultradent Products, Inc. Sustained release method for treating teeth surfaces
US5855870A (en) 1990-03-22 1999-01-05 Ultradent Products, Inc. Method for treating sensitive teeth
US5851512A (en) 1990-03-22 1998-12-22 Ultradent Products, Inc. Dental compositions having a sticky matrix material for treating sensitive teeth
US5376006A (en) 1990-03-22 1994-12-27 Ultradent Products, Inc. Dental bleaching compositions and methods for bleaching teeth surfaces
US5985249A (en) 1990-03-22 1999-11-16 Ultradent Products, Inc. Sticky dental compositions for adhering a passive-type dental tray over a person's teeth
US6306370B1 (en) * 1997-05-30 2001-10-23 Ultradent Products, Inc. Compositions and methods for whitening and desensitizing teeth
US6036943A (en) 1990-03-22 2000-03-14 Ultradent Products, Inc. Methods for treating a person's teeth using sticky dental compositions in combination with passive-type dental trays
EP0537165B1 (en) * 1990-04-27 1998-07-01 Allergan, Inc. Polymeric drug delivery system
DE4018247C2 (en) * 1990-06-07 1992-05-14 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg, 5450 Neuwied, De
US5455043A (en) * 1990-06-13 1995-10-03 Fischel-Ghodsian; Fariba Device for controlled release of vaporous medications through nasal route
US5059417A (en) 1990-06-26 1991-10-22 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Peroxide gel dentifrice
US5344702A (en) * 1990-09-14 1994-09-06 Hoechst Celanese Corp. Coated fibers
US5076791A (en) 1990-10-22 1991-12-31 Madray Jr George Professional home method for bleaching teeth
US5326685A (en) * 1991-02-13 1994-07-05 Gaglio Thomas J Viscous fluid dispensing apparatus
US5707736A (en) * 1991-04-04 1998-01-13 Sion Texo Medic Ltd. Products having anti-microbial activity
RU2106136C1 (en) * 1991-04-23 1998-03-10 Перио Продактс Лимитед Film-forming liquid polymeric composition, method for external and internal bleaching of teeth, method for treating gingivitis and dental calculus
JPH07215843A (en) 1991-05-30 1995-08-15 Recordati Sa Controlled release pharmaceutical composition having bioadhesive property
US5340581A (en) * 1991-08-23 1994-08-23 Gillette Canada, Inc. Sustained-release matrices for dental application
DE69227777T2 (en) * 1991-08-23 1999-05-27 Gillette Co Matrices sustained release for dental purposes
US5171564A (en) * 1991-09-13 1992-12-15 Colgate-Palmolive Aqueous tooth whitening dentifrice
US5256402A (en) 1991-09-13 1993-10-26 Colgate-Palmolive Company Abrasive tooth whitening dentifrice of improved stability
US5279816A (en) * 1991-11-22 1994-01-18 Colgate-Palmolive Co. Oral composition having improved tooth whitening effect
US5252577A (en) * 1992-03-06 1993-10-12 Gillette Canada, Inc. Methods of desensitizing teeth
CA2078960A1 (en) 1992-04-21 1993-10-22 John Wick Hydrogel applicator and methods of making same
DE69312487D1 (en) 1992-05-18 1997-08-28 Minnesota Mining & Mfg Means for transmucosal drug delivery
JP3158364B2 (en) * 1992-10-13 2001-04-23 ソニー株式会社 Electronics
US5345551A (en) * 1992-11-09 1994-09-06 Brigham Young University Method and system for synchronization of simultaneous displays of related data sources
US5863202A (en) * 1992-11-24 1999-01-26 Fontenot; Mark G. Device and method for treatment of dentition
US5575654A (en) * 1992-11-24 1996-11-19 Fontenot; Mark G. Apparatus and method for lightening teeth
US5980249A (en) 1992-11-24 1999-11-09 Folh, Llc Method and device for treatment of dentition
US5340314A (en) * 1992-11-27 1994-08-23 Tarvis Jo Ellen Method of bonding and relining dentures
US5489624A (en) * 1992-12-01 1996-02-06 Minnesota Mining And Manufacturing Company Hydrophilic pressure sensitive adhesives
US5723843A (en) * 1993-01-28 1998-03-03 Illuminated Display Division Of Bell Industries, Inc. Method of forming and balancing an illuminated display panel
US5302374A (en) * 1993-04-21 1994-04-12 Dental Concepts Inc. Oral hygiene system
US5362496A (en) * 1993-08-04 1994-11-08 Pharmetrix Corporation Method and therapeutic system for smoking cessation
CA2169729C (en) * 1993-08-19 2001-04-03 James E. Biegajski Water-soluble pressure-sensitive mucoadhesive
CA2095445A1 (en) 1994-01-10 1995-07-11 Howard Rocket Index dental tooth cleanser
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
KR100195873B1 (en) * 1994-03-07 1999-06-15 챨스 디 에버트 Drug-containing adhesive composite transdermal delivery device
US5819765A (en) 1994-05-11 1998-10-13 Mittiga; Maria Ida Finger glove comprising areas prepared for oral hygiene
US5560379A (en) * 1994-08-12 1996-10-01 Pieczenik; George Dental paper pick and flosser
RU2075965C1 (en) * 1994-09-29 1997-03-27 Гарник Алексанович Чухаджян Agent for mouth cavity illness treatment
US5522726A (en) 1994-10-27 1996-06-04 Hodosh; Milton Method for anesthetizing teeth
US5599527A (en) 1994-11-14 1997-02-04 Colgate-Palmolive Company Dentifrice compositions having improved anticalculus properties
US5565190A (en) 1994-11-14 1996-10-15 Colgate Palmolive Company Dentifrice compositions containing reactive ingredients stabilized with alkali metal compounds
US5614174A (en) 1994-11-14 1997-03-25 Colgate Palmolive Company Stabilized dentifrice compositions containing reactive ingredients
US5665333A (en) * 1995-01-17 1997-09-09 Homola; Andrew M. Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
US5635162A (en) * 1995-02-23 1997-06-03 Ultradent Products, Inc. Hemostatic composition for treating gingival area
WO1996025910A1 (en) * 1995-02-23 1996-08-29 Cygnus, Inc. Water-soluble pressure-sensitive mucoadhesive
US5722833A (en) * 1995-03-21 1998-03-03 Ultradent Products, Inc. Viscous neutralizing barrier
US5603701A (en) * 1995-03-27 1997-02-18 Ultradent Products, Inc. Syringe apparatus with threaded plunger for delivering tooth composites and other solid yet pliable materials
US5618273A (en) * 1995-03-27 1997-04-08 Ultradent Product, Inc. Syringe apparatus with threaded plunger for delivering tooth composites and other solid yet pliable materials
US5707235A (en) * 1995-04-03 1998-01-13 Knutson; Eric J. Dental tray spacer
US5534562A (en) * 1995-04-07 1996-07-09 Ultradent Products, Inc. Compositions and methods for priming and sealing dental and biological substrates
US5616027A (en) * 1995-04-18 1997-04-01 Jacobs; Allison J. Custom dental tray
JPH08311441A (en) * 1995-05-24 1996-11-26 Tokuyama Corp Production of photochromic cured object
US6217335B1 (en) * 1996-06-06 2001-04-17 Ultradent Products, Inc. Endodontic systems and methods for the anatomicall, sectional and progressive corono-apical preparation of root canals with minimal apical intrusion
US6379155B1 (en) * 1996-06-06 2002-04-30 Ultradent Products, Inc. Endodontic systems and methods for the anatomical, sectional and progressive corono-apical preparation of root canals with instruments utilizing stops
US5648064A (en) * 1995-07-07 1997-07-15 Gaffar; Abdul Oral compositions having accelerated tooth whitening effect
US5620322A (en) * 1995-07-27 1997-04-15 Lococo; Michael Dental matrix strip
CA2184316A1 (en) * 1995-09-12 1997-03-13 Wei-Chi Liao Buccal delivery system for therapeutic agents
WO1997011676A1 (en) 1995-09-25 1997-04-03 Robert Eric Montgomery Tooth bleaching compositions
US5611687A (en) * 1995-11-06 1997-03-18 Dental Concepts Inc. Oral hygiene delivery system
US5713738A (en) * 1995-12-12 1998-02-03 Britesmile, Inc. Method for whitening teeth
US5662758A (en) 1996-01-10 1997-09-02 The Procter & Gamble Company Composite material releasably sealable to a target surface when pressed thereagainst and method of making
US5631000A (en) 1996-03-11 1997-05-20 Laclede Professional Products, Inc. Anhydrous tooth whitening gel
US5678273A (en) 1996-03-20 1997-10-21 Porcelli; V. Lorenzo Disposable oral hygiene applicator
JPH1017448A (en) * 1996-06-28 1998-01-20 Lion Corp Plaster for oral cavity
US5827591A (en) 1996-10-08 1998-10-27 Tricor Direct, Inc. Removable adhesive notes for an industrial setting
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
WO1998017263A1 (en) * 1996-10-25 1998-04-30 Copley Pharmaceutical Inc. Transdermal patch
US5766011A (en) * 1996-11-27 1998-06-16 Sibner; Jeffrey A. Dental bleaching composition and method
US5858332A (en) 1997-01-10 1999-01-12 Ultradent Products, Inc. Dental bleaching compositions with high concentrations of hydrogen peroxide
US6391283B1 (en) * 1997-01-10 2002-05-21 Ultradent Products, Inc. Methods and apparatus for activating dental compositions
US5788579A (en) * 1997-01-14 1998-08-04 Cherry; Steve R. Illusion mirror light display
US6094889A (en) 1997-02-25 2000-08-01 Exxon Chemical Patents, Inc. Method of form and seal packaging
US5820854A (en) * 1997-03-27 1998-10-13 The Procter & Gamble Company Oral compositions containing polyoxyethylene
US5953885A (en) 1997-04-08 1999-09-21 Retail Communications Corp. Cosmetic sampler and method of making using bulk thin film application techniques
US5989569A (en) * 1997-06-06 1999-11-23 The Procter & Gamble Company Delivery system for a tooth whitener using a permanently deformable strip of material
US6045811A (en) * 1997-06-06 2000-04-04 The Procter & Gamble Company Delivery system for an oral care substance using a permanently deformable strip of material
US6136297A (en) * 1997-06-06 2000-10-24 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US5968633A (en) 1997-06-06 1999-10-19 The Procter & Gamble Company Selectively-activatible sheet material for dispensing and dispersing a substance onto a target surface
US5894017A (en) * 1997-06-06 1999-04-13 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US6096328A (en) * 1997-06-06 2000-08-01 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US5879691A (en) * 1997-06-06 1999-03-09 The Procter & Gamble Company Delivery system for a tooth whitener using a strip of material having low flexural stiffness
US6197331B1 (en) * 1997-07-24 2001-03-06 Perio Products Ltd. Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity
US5860809A (en) * 1997-08-04 1999-01-19 Meehan; Frank P. Lipstick display and device
US6375463B1 (en) * 1998-04-22 2002-04-23 Ultradent Products, Inc. Dental wedges having proximal ends with gritty top layers
US6309625B1 (en) * 1998-11-12 2001-10-30 Ultradent Products, Inc. One-part dental compositions and methods for bleaching and desensitizing teeth
US6030222A (en) * 1998-12-01 2000-02-29 Tarver; Jeanna G. Dye compositions and methods for whitening teeth using same
US6361844B1 (en) * 1999-01-27 2002-03-26 David T. Ou-Yang Release article and adhesive article comprising the release article
US6277458B1 (en) * 1999-03-15 2001-08-21 The Procter & Gamble Company Release strip with partible break to facilitate
US20020018754A1 (en) * 1999-03-15 2002-02-14 Paul Albert Sagel Shapes for tooth whitening strips
DE60002471T2 (en) * 1999-07-02 2004-02-19 The Procter & Gamble Company, Cincinnati Compositions for the release of oral care active ingredients comprising organosiloxane resins by use of a carrier strip redetachable
US6649147B1 (en) * 1999-07-02 2003-11-18 The Procter & Gamble Company Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip
US6400801B1 (en) * 1999-07-19 2002-06-04 Ultradent Products, Inc. Smooth radiopaque endodontic marking tools and related methods
US6234793B1 (en) * 1999-07-19 2001-05-22 Ultradent Products, Inc. Textured dental matrix bands and related methods
US6322360B1 (en) * 1999-10-22 2001-11-27 3M Innovative Properties Company Medication retention assembly for oral delivery tray
US20010009755A1 (en) * 2000-01-21 2001-07-26 Fischer Dan E. Multiple material dispensing systems with flexible coupling tubes
DK1267812T3 (en) * 2000-03-17 2009-04-27 Lg Household & Health Care Ltd Patches for teeth whitening
US6582708B1 (en) * 2000-06-28 2003-06-24 The Procter & Gamble Company Tooth whitening substance
KR100645269B1 (en) * 2000-06-28 2006-11-15 더 프록터 앤드 갬블 캄파니 Structures and compositions increasing the stability of peroxide actives
US7040893B2 (en) * 2000-10-30 2006-05-09 Ultradent Products, Inc. Fiber-covered dental delivery instruments
US6343932B1 (en) * 2000-11-13 2002-02-05 Peter E. Wiesel Delivery system for whitening teeth
US6500408B2 (en) * 2001-01-27 2002-12-31 Jc Technologies, Inc. Enamel-safe tooth bleach and method for use
US6514483B2 (en) * 2001-03-12 2003-02-04 Colgate Palmolive Company Strip for whitening tooth surfaces
US20020146666A1 (en) * 2001-04-04 2002-10-10 Sagel Paul Albert Kits for whitening teeth
US8840918B2 (en) * 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US6503485B1 (en) * 2001-08-06 2003-01-07 Ultradent Products, Inc. Two-part dental bleaching systems having improved gel stability and methods for bleaching teeth using such systems
US6729879B2 (en) * 2002-03-13 2004-05-04 Ultradent Products, Inc. Dental bonding methods for adhering amalgam restoratives to dental substrates
US6756417B2 (en) * 2002-03-13 2004-06-29 Ultradent Products, Inc. Dental bonding compositions for adhering amalgam restoratives to dental substrates
US8524200B2 (en) * 2002-09-11 2013-09-03 The Procter & Gamble Company Tooth whitening products
US20050100515A1 (en) * 2002-09-11 2005-05-12 The Procter & Gamble Company Tooth whitening products
US20040120903A1 (en) * 2002-09-11 2004-06-24 The Procter & Gamble Company Tooth whitening strips
US20050019277A1 (en) * 2002-09-11 2005-01-27 The Procter & Gamble Company Tooth whitening products
US6916463B2 (en) * 2002-09-24 2005-07-12 The Procter & Gamble Company Oral products having an aesthetic layer
US6994546B2 (en) * 2002-12-18 2006-02-07 Ultradent Products, Inc. Light curing device with detachable power supply
US20040122377A1 (en) * 2002-12-19 2004-06-24 Fischer Dan E. Syringe delivery tip adapted to provide controlled flow rate
US7198623B2 (en) * 2003-01-10 2007-04-03 Ultradent Products, Inc. Fiber-coated dental infusor systems and methods of use
US6860736B2 (en) * 2003-05-23 2005-03-01 Ultradent Products, Inc. Oral treatment devices that include a thin, flexible barrier layer and an endoskeleton treatment or adhesive composition
US20040214130A1 (en) * 2003-04-25 2004-10-28 Ultradent Products, Inc. Flexible translucent protective covers used to protect dental appliances from rigid light emitting devices
US7398598B2 (en) * 2003-05-13 2008-07-15 Ultradent Products, Inc. Methods for manufacturing endodontic instruments
US7040897B2 (en) * 2003-05-23 2006-05-09 Ultradent Products, Inc. Thin, flexible membrane dental trays and systems and methods utilizing such trays
US7048543B2 (en) * 2003-05-27 2006-05-23 Ultradent Products, Inc. Substantially solid bleaching composition in a tray-like configuration
US7074042B2 (en) * 2003-05-27 2006-07-11 Ultradent Products, Inc. Tray-like dental bleaching devices having a barrier layer and a substantially solid bleaching composition
US7059857B2 (en) * 2003-05-27 2006-06-13 Ultradent Products, Inc. Substantially solid desensitizing compositions and devices having a tray-like configuration and methods of manufacturing and using such compositions and devices
US7172423B2 (en) * 2003-05-27 2007-02-06 Ultradent Products, Inc. Substantially solid bleaching or treatment compositions in the form of inserts for dental trays, and kits comprising such inserts and trays
US7052275B2 (en) * 2003-05-27 2006-05-30 Ultradent Products, Inc. Kits and methods for bleaching and desensitizing teeth
US7056118B2 (en) * 2003-05-27 2006-06-06 Ultradent Products, Inc. Compositions and devices having a tray-like configuration for delivering a medicament and methods of manufacturing and using such compositions and devices
US20050064371A1 (en) * 2003-07-21 2005-03-24 Soukos Nikos S. Method and device for improving oral health
US20050016884A1 (en) * 2003-07-25 2005-01-27 Gary Stout Orthodontic bracket packaging kits and systems
US7192276B2 (en) * 2003-08-20 2007-03-20 Ultradent Products, Inc. Dental curing light adapted to emit light at a desired angle
US6997708B2 (en) * 2003-10-22 2006-02-14 Ultradent Products, Inc. Treatment compositions and strips having a solid adhesive layer and treatment gel adjacent thereto
US7011523B2 (en) * 2003-10-22 2006-03-14 Ultradent Products, Inc. Bleaching compositions and devices having a solid adhesive layer and bleaching gel adjacent thereto
US6981874B2 (en) * 2003-10-22 2006-01-03 Ultradent Products, Inc. Dental bleaching compositions and devices having a solid activation adhesive layer or region and bleaching gel layer or region
US7534264B2 (en) * 2004-01-28 2009-05-19 Ultradent Products, Inc. Delivery system for bone growth promoting material
US7059858B2 (en) * 2004-02-19 2006-06-13 Ultradent Products, Inc. Universal tray design having anatomical features to enhance fit
US7192280B2 (en) * 2004-02-19 2007-03-20 Ultradent Products, Inc. Dental bleaching devices having a protective adhesive region
US6997706B2 (en) * 2004-03-04 2006-02-14 Ultradent Products, Inc. Fluoride-releasing pellet kit
US7168951B2 (en) * 2004-06-09 2007-01-30 Ultradent Products, Inc. Reinforced gingival retraction cord
US20070086861A1 (en) * 2005-10-13 2007-04-19 Pratt Samuel S Ground compacting apparatus
KR100698013B1 (en) * 2005-12-08 2007-03-23 한국전자통신연구원 Schottky Barrier Tunneling Transistor and Manufacturing Method of it

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US533076A (en) * 1895-01-29 Mechanical movement
US2835628A (en) * 1957-04-01 1958-05-20 Jacob A Saffir Means for treating teeth
US3256014A (en) * 1963-04-05 1966-06-14 Technical Displays Inc Display device with two rheostats
US3444858A (en) * 1965-05-14 1969-05-20 Higham S Russell Method and means for administering drugs
US3659928A (en) * 1969-05-12 1972-05-02 John Alan Davis Reflection apparatus for simulating the effect of use by a person of a cosmetic or article
US3657413A (en) * 1969-08-28 1972-04-18 Block Drug Co Antiseptic composition containing peroxide glycerol and carboxypolymethylene polymer
US3640741A (en) * 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3711182A (en) * 1971-05-17 1973-01-16 J Jasgur Glareless mirror using relatively rotatable polarizers
US3784390A (en) * 1971-07-23 1974-01-08 Hayashibara Biochem Lab Shaped bodies of pullulan and their use
US4251400A (en) * 1971-11-03 1981-02-17 Borden, Inc. Hot and cold water redispersible polyvinyl acetate adhesives
US3729839A (en) * 1971-12-30 1973-05-01 J Bourdier Installation for trying on wearing apparel and accessories
US3859987A (en) * 1972-04-17 1975-01-14 Harald Holstad Mirror, particularly for examination of cavities, for example, surgical mirrors or dental mirrors
US3964164A (en) * 1973-02-05 1976-06-22 Hesselgren Sven Gunnar Method of applying preventive and therapeutic agents
US4032627A (en) * 1973-04-02 1977-06-28 Koh-I-Noor Rapidograph, Inc. Tooth whitening cosmetic composition
US4136162A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US4136145A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US3955281A (en) * 1974-12-05 1976-05-11 Pacemaker Corporation Disposable dental tray for topical application of fluoride gel and other dental medications
US4138314A (en) * 1975-04-10 1979-02-06 Basf Wyandotte Corporation Method of forming diaphragms from discrete thermoplastic fibers requiring no bonding or cementing
US4325855A (en) * 1975-09-10 1982-04-20 Lingner And Fischer Gmbh Adhesives
US4072551A (en) * 1975-12-15 1978-02-07 Hoffman-La Roche Inc. Novel dosage form
US4031200A (en) * 1975-12-15 1977-06-21 Hoffmann-La Roche Inc. Manufacture of pharmaceutical unit dosage forms
US4029758A (en) * 1975-12-15 1977-06-14 Hoffmann-La Roche Inc. Preparation of pharmaceutical unit dosage forms
US4029757A (en) * 1975-12-15 1977-06-14 Hoffmann-La Roche Inc. Manufacture of pharmaceutical unit dosage forms
US4084700A (en) * 1976-02-06 1978-04-18 Optarac Corporation Display rack
US4138814A (en) * 1976-03-08 1979-02-13 Pacemaker Corporation Disposable dental tray for topical application of fluoride gel and other dental medications
US4139627A (en) * 1977-10-06 1979-02-13 Beecham Inc. Anesthetic lozenges
US4182222A (en) * 1978-02-16 1980-01-08 Stahl Robert L Coupon confining bag method
US4335731A (en) * 1978-07-25 1982-06-22 Bora Jr F William Device for oral hygiene care
US4324547A (en) * 1978-09-16 1982-04-13 Vishay Intertechnology, Inc. Dentistry technique
US4376628A (en) * 1979-05-09 1983-03-15 B.V. Gaba Device for treating teeth
US4442258A (en) * 1979-07-04 1984-04-10 Nitto Electric Industrial Co., Ltd. Water-soluble pressure-sensitive adhesive composition
US4273418A (en) * 1979-11-30 1981-06-16 Wham-O Mfg. Co. Mirror for producing optical illusions
US4515162A (en) * 1980-03-14 1985-05-07 Nitto Electric Industrial Co., Ltd. Electrode pad
US4517173A (en) * 1980-09-26 1985-05-14 Nippon Soda Co. Ltd. Mucous membrane-adhering film preparation and process for its preparation
US4522806A (en) * 1980-10-10 1985-06-11 Lever Brothers Company Oral compositions for hexetidine and zinc salts for the synergistic inhibition of dental plaque
US4331576A (en) * 1981-01-29 1982-05-25 Herman Colon Water-soluble, pressure-sensitive, hot-melt adhesives
US4438258A (en) * 1981-06-12 1984-03-20 National Research Development Corporation Hydrogels
US4503070A (en) * 1981-07-31 1985-03-05 Eby Iii George A Method for reducing the duration of the common cold
US4373036A (en) * 1981-12-21 1983-02-08 Block Drug Company, Inc. Denture fixative composition
US4428373A (en) * 1982-02-03 1984-01-31 Sultan Dental Products Limited Disposable dental tray
US4518721A (en) * 1982-03-26 1985-05-21 Richardson-Vicks Inc. Hydrophilic denture adhesive
US4431631A (en) * 1983-01-03 1984-02-14 Colgate-Palmolive Company Aqueous oral solution
US4592726A (en) * 1983-01-03 1986-06-03 Herbert Brilliant Diagnostic mirror and light filter
US4983379A (en) * 1983-03-01 1991-01-08 Schaeffer Hans A Dental preparation, article and method for storage and delivery thereof
US4522805A (en) * 1983-06-08 1985-06-11 Norman Gordon Tooth and gum dentifrice
US4522593A (en) * 1983-07-07 1985-06-11 Fischer Dan E Knitted gingival retraction cord
US5024701A (en) * 1983-08-01 1991-06-18 Hercules Incorporated Denture adhesive composition
US5186938A (en) * 1984-07-24 1993-02-16 Key Pharmaceuticals, Inc. Adhesive transdermal dosage layer
US4593053A (en) * 1984-12-07 1986-06-03 Medtronic, Inc. Hydrophilic pressure sensitive biomedical adhesive composition
US4650665A (en) * 1985-02-08 1987-03-17 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4837008A (en) * 1985-04-09 1989-06-06 Peroxydent Group Periodontal composition and method
US4640685A (en) * 1985-04-15 1987-02-03 Croll Theodore P Hand-held light filter
US5288498A (en) * 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
US4592488A (en) * 1985-05-24 1986-06-03 Simon Gilbert I Method for the preparation of chemotherapeutic compositions for the treatment of periodontal disease, compositions therefor and use thereof
US4592487A (en) * 1985-07-03 1986-06-03 Simon Gilbert I Dentifrices
US4741941A (en) * 1985-11-04 1988-05-03 Kimberly-Clark Corporation Nonwoven web with projections
US4983381A (en) * 1985-12-30 1991-01-08 Futura Medical S.A. Method and device for producing the whitening of live teeth with pathological and normal colorations
US4661070A (en) * 1986-03-17 1987-04-28 Joshua Friedman Method for bleaching discolored teeth
US4722761A (en) * 1986-03-28 1988-02-02 Baxter Travenol Laboratories, Inc. Method of making a medical electrode
US4728291A (en) * 1986-06-26 1988-03-01 Golub Jeff E Cloth wrap dental process
US4799888A (en) * 1986-06-26 1989-01-24 Golub Jeff E Dental process with treated fabric
US4741700A (en) * 1986-07-16 1988-05-03 Barabe David J Dental breath freshening device
US4927636A (en) * 1986-11-11 1990-05-22 501 Kabushiki Kaisha Hayashibara Kagaku Kenkyujo Association complex comprising pullulan and polyethylene glycol, and preparation and uses of the same
US4900554A (en) * 1986-12-24 1990-02-13 Teikoku Seiyaku Co., Ltd. Adhesive device for application to body tissue
US4812308A (en) * 1987-02-20 1989-03-14 Church & Dwight Co., Inc. Hydrogen peroxide-releasing tooth powder
US4895517A (en) * 1987-04-14 1990-01-23 Ultradent Products, Inc. Methods for performing vital dental pulpotomy
US4839156A (en) * 1987-04-17 1989-06-13 Colgate-Palmolive Company Stable hydrogen peroxide dental gel
US4839157A (en) * 1987-04-17 1989-06-13 Colgate-Palmolive Company Stable hydrogen peroxide dental gel containing fumed silicas
US4900253A (en) * 1987-07-15 1990-02-13 Landis Timothy J Dental mirror having ultraviolet filter
US4931282A (en) * 1987-11-25 1990-06-05 Minnesota Mining And Manufacturing Company Pressure-sensitive medical sealant
US4927634A (en) * 1987-12-16 1990-05-22 Richardson-Vicks Inc. Pharmaceutical compositions containing dyclonine HC1 and phenol
US4895721A (en) * 1988-01-22 1990-01-23 Carter-Wallace Inc. Peroxide gel dentifrice compositions
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
US4900552A (en) * 1988-03-30 1990-02-13 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
US4902227A (en) * 1988-05-04 1990-02-20 Pascal Company, Inc. Dental treatment tray
US4828113A (en) * 1988-05-18 1989-05-09 Friedland Jeffrey B Dental treatment kit
US4990089A (en) * 1988-08-23 1991-02-05 Dunhall Pharmaceuticals, Inc. Method and material for brightening teeth
US4910247A (en) * 1989-03-27 1990-03-20 Gaf Chemicals Corporation Adhesive composition
US4919615A (en) * 1989-04-28 1990-04-24 Croll Theodore P Orthodontic band cap
US4988500A (en) * 1989-09-29 1991-01-29 The Procter & Gamble Company Oral compositions
US5001170A (en) * 1989-12-01 1991-03-19 Warner-Lambert Company Denture stabilizer
US5409631A (en) * 1990-03-22 1995-04-25 Ultradent Products Dental bleaching compositions and methods for bleaching teeth surfaces
US5098303A (en) * 1990-03-22 1992-03-24 Ultradent Products, Inc. Method for bleaching teeth
US5380198A (en) * 1990-08-06 1995-01-10 Suhonen; Jouko Matrix for dental medicine and a device for the fabricaton of matrix bands
US5401495A (en) * 1990-10-10 1995-03-28 Natural White, Inc. Teeth whitener
US5290566A (en) * 1990-12-18 1994-03-01 Schow Robert S Tooth whitening formulation and method
US5401528A (en) * 1991-03-19 1995-03-28 Thera Patent GmbH & Co. KG Geselleschaft fur industrielle Schutzrechte Use of compositions based on organically modified silicic acid polycondensates for coating teeth and dental prostheses
US5084268A (en) * 1991-06-17 1992-01-28 Dental Concepts, Inc. Tooth whitening dentifrice
US5211559A (en) * 1991-07-18 1993-05-18 Gillette Canada Inc. Dental treatment tray for holding medicament gel
US5314915A (en) * 1991-09-25 1994-05-24 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
US5192802A (en) * 1991-09-25 1993-03-09 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
US5310563A (en) * 1991-10-25 1994-05-10 Colgate-Palmolive Company Dental material and method for applying preventative and therapeutic agents
US5393528A (en) * 1992-05-07 1995-02-28 Staab; Robert J. Dissolvable device for contraception or delivery of medication
US5599553A (en) * 1992-09-01 1997-02-04 Dong Kook Pharmaceutical Co., Ltd. Local drug delivery film for periodontal treatment
US5387103A (en) * 1993-02-16 1995-02-07 Ultradent Products, Inc. Syringe apparatus for delivering tooth composites and other solid yet pliable materials
US5288231A (en) * 1993-03-08 1994-02-22 Pinnacle Products, Inc. Light shield for dental apparatus
US5509800A (en) * 1993-08-20 1996-04-23 Cunningham; Peter J Light-filter for dental use
US5505933A (en) * 1994-06-27 1996-04-09 Colgate Palmolive Company Desensitizing anti-tartar dentifrice

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019277A1 (en) * 2002-09-11 2005-01-27 The Procter & Gamble Company Tooth whitening products
US20110014252A1 (en) * 2002-09-11 2011-01-20 Paul Albert Sagel Tooth whitening products
US9554976B2 (en) 2002-09-11 2017-01-31 The Procter & Gamble Company Tooth whitening product
US20110070560A1 (en) * 2009-09-23 2011-03-24 Paul Hertz Tooth-whitening method

Also Published As

Publication number Publication date Type
US6551579B2 (en) 2003-04-22 grant
US20030211056A1 (en) 2003-11-13 application
US20080025923A1 (en) 2008-01-31 application
US20070248634A1 (en) 2007-10-25 application
US20080025928A1 (en) 2008-01-31 application
US20050238591A1 (en) 2005-10-27 application
US20080025924A1 (en) 2008-01-31 application
US20010053375A1 (en) 2001-12-20 application
US20070086961A1 (en) 2007-04-19 application
US20080031910A1 (en) 2008-02-07 application
US20020012685A1 (en) 2002-01-31 application
US20020006388A1 (en) 2002-01-17 application
US20080026021A1 (en) 2008-01-31 application
US6096328A (en) 2000-08-01 grant

Similar Documents

Publication Publication Date Title
Rodrigues et al. Microhardness evaluation of in situ vital bleaching on human dental enamel using a novel study design
US5900230A (en) Dental products to treat and prevent periodontal disease
US6500406B1 (en) Denture care compositions and kits
US20080274066A1 (en) Compositions, Methods, Devices, and Kits for Maintaining or Enhancing Tooth Whitening
US5875798A (en) Therapeutic toothpick for treating oral and systemic diseases
US6569408B1 (en) Compositions comprising organosiloxane resins for delivering oral care substances
US20020018754A1 (en) Shapes for tooth whitening strips
US20060024246A1 (en) Oral care compositions with film forming polymers
US6509007B2 (en) Oral care kits and compositions
US6685921B2 (en) Dental care compositions
US20020146666A1 (en) Kits for whitening teeth
US6589512B1 (en) Compositions comprising organosiloxane resins for delivering oral care substances
US6949240B2 (en) Tooth whitening products
US6582708B1 (en) Tooth whitening substance
US20050137109A1 (en) Emulsion composition for delivery of bleaching agents to teeth
US20060045854A1 (en) Oral care composition with cross-linked polymer peroxide
US20050210615A1 (en) Oral care method
US20050095208A1 (en) Oral care compositions for topical application
US20060292090A1 (en) Oral care compositions, devices, and methods of using the same
US5891453A (en) Delivery system for a tooth whitener using a strip of material having low flexural stiffness
US20050196358A1 (en) Film products having controlled disintegration properties
US20050260544A1 (en) Novel device
US6649147B1 (en) Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip
US20040037789A1 (en) Method of applying oral composition
US20050036957A1 (en) Tooth whitening dental tray and method of use