US20070273831A1 - Automated fundus imaging system - Google Patents
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- US20070273831A1 US20070273831A1 US11/835,588 US83558807A US2007273831A1 US 20070273831 A1 US20070273831 A1 US 20070273831A1 US 83558807 A US83558807 A US 83558807A US 2007273831 A1 US2007273831 A1 US 2007273831A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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- This invention generally relates to electronic imaging apparatus for fundus imaging and more particularly relates to an improved fundus imaging apparatus for automated imaging without operator intervention.
- Fundus camera imaging is acknowledged to be an important diagnostic tool for detection of various conditions affecting the eye, including diabetic retinopathy and macular degeneration.
- Various embodiments of fundus imaging apparatus are disclosed, for example in U.S. Pat. Nos. 5,713,047 (Kohayakawa); 5,943,116 (Zeimer); 5,572,266 (Ohtsuka); 4,838,680 (Nunokawa); 6,546,198 (Ohtsuka); and 6,636,696 (Saito).
- U.S. Pat. No. 6,296,358 discloses an automated sequence that is executed for pupil alignment and focusing.
- U.S. Pat. No. 4,732,466 discloses an automated focus mechanism for a fundus imaging apparatus.
- U.S. Pat. No. 6,733,129 discloses an automatic alignment sequence using a feedback loop with a light beam projected onto the cornea, a sensor for sensing reflected light, and a series of motors for effecting alignment adjustment.
- 6,705,726 discloses a multi-function optical imaging apparatus with a number of automation features in various subsystems.
- U.S. Pat. No. 6,830,336 discloses automation of the sequencing of images for a patient, in order to obtain a complete series of fundus images once the patient is properly positioned and suitable focus has been achieved.
- a number of fundus imaging apparatus are designed for the more limited function of diabetic retinopathy screening. These devices are intended to be used by relatively unskilled operators who receive minimal training. For example, these lower cost fundus imaging apparatus are intended to be installed at a personal care physician (PCP) office or in medical test lab collection facility, rather than at a specialist's facility. The intent is to have these apparatus operated by a clerical staff of medical technicians at the PCP office of other site, to obtain images for first-level screening.
- PCP personal care physician
- these fundus imaging apparatus are designed with an operator interface that provides controls for operation, with operator feedback as well as automated response to events such as patient head and eye movement.
- an apparatus for obtaining a retinal image from an eye comprises:
- FIG. 1 is a schematic block diagram of a fundus imaging apparatus
- FIG. 2 is a schematic block diagram showing subsystem components of the imaging apparatus of the present invention.
- FIG. 3 is a schematic block diagram showing the overall arrangement of illumination apparatus components within a conventional fundus imaging apparatus
- FIG. 4 is a plan view of a ring-slit diaphragm used in a conventional fundus imaging apparatus
- FIG. 5 is a plan view representation of the ring of illumination applied to the pupil of a patient in a conventional apparatus
- FIG. 6 is a schematic block diagram of a fundus imaging apparatus in one embodiment
- FIG. 7 is a process flow diagram showing the basic steps used for obtaining a retinal image using the imaging system of the present invention.
- FIGS. 8A, 8B , and 8 C are plan views showing an arrangement of operator interface display screens for a conventional fundus imaging apparatus
- FIG. 9A is a schematic block diagram showing alignment apparatus according to one embodiment.
- FIG. 9B is a plan view showing an arrangement of illumination rings used for cornea focus
- FIGS. 10A, 10B , and 10 C are side view block diagrams showing cornea focus in one embodiment
- FIG. 11 is a plan view of the sensor field for cornea focus
- FIGS. 12A, 12B , and 12 C are side view block diagrams showing retina focus in one embodiment
- FIG. 13 is a plan view of the sensor field for retina focus
- FIG. 14 is a schematic diagram showing how cornea focus is achieved in one embodiment
- FIG. 15 is a schematic diagram showing how cornea focus is achieved in another embodiment
- FIG. 16 is a schematic diagram showing how retinal focus can be obtained in one embodiment
- FIG. 17 is a schematic diagram showing how retinal focus can be obtained in an alternate embodiment
- FIG. 18 is a plan view of the sensor field for a retina out-of-focus condition in one embodiment
- FIG. 19 is a plan view of the sensor field for the retina in-focus condition in one embodiment
- FIG. 20 is a schematic diagram showing how retinal focus can be obtained in an alternate embodiment
- FIG. 21 is a plan view showing the sensor field for a retina out-of-focus condition in the embodiment of FIG. 20 ;
- FIG. 22 is a schematic view of components for cornea focus in an alternate embodiment
- FIG. 23 is a schematic view of components for cornea focus in another alternate embodiment
- FIG. 24 is a schematic view of components for retinal focus in an alternate embodiment.
- FIG. 25 is a block diagram showing a fiber-optic illumination ring in one embodiment.
- a control workstation 210 has a display 138 , a keyboard 212 , and a control logic processor 214 for providing control logic and interface functions for an operator 400 .
- Imaging functions are provided by optical, electro-optical, and electronic components within a fundus imaging appliance 220 .
- a network 216 allows communication between fundus imaging system 100 and processing and storage devices at other networked sites. Using network 216 , for example, fundus images obtained by fundus imaging system 100 can be uploaded to other sites, such as to sites where diagnostic assessment is performed remotely. Alternately, software, instructions, or other data could be downloaded from other networked sites to fundus imaging system 100 or to control workstation 210 .
- control logic processor 214 may be performed by logic components within fundus imaging appliance 220 , rather than by a separately packaged processor, as shown in FIG. 1 .
- camera interface devices, operating controls, and display could be located on the body of fundus imaging appliance 220 itself, for example.
- Operator interface functions provided by display 138 and keyboard 212 could be combined in a touchscreen console, for example.
- the connection to network 216 may be a standard Ethernet connection, a dedicated network telecommunications connection, or a dial-up modem. In one embodiment, network 216 allows wireless connection. Alternately, the connection to network 216 may be dispensed with altogether, such that imaging appliance 220 records fundus imaging data onto a data storage medium such as a removable storage medium, which could be as a magnetic, electronic, or optical storage medium, for example.
- FIG. 2 there is shown a high-level schematic block diagram of key subsystems of fundus imaging appliance 220 .
- the relative position of eye E is shown on an optical axis O. Alignment of illumination and imaging optics and delivery of light to the eye is performed by an illumination section 112 .
- An image capture section 102 then cooperates with illumination section 112 components to obtain the retinal images from eye E.
- a control logic processor 104 within fundus imaging appliance 220 controls illumination section 112 and image capture section 102 components to maintain proper alignment relative to eye E and provide the optimal lighting characteristics for retinal imaging.
- Control logic processor 104 also executes pupil-tracking algorithms and provides signals for controlling imaging operation. Operator commands at control workstation 210 ( FIG. 1 ) are provided to control logic processor 104 for manipulating component positioning, illumination, and imaging functions.
- FIG. 3 there is shown a schematic diagram of a fundus imaging apparatus 10 in which a conventional illumination section 12 is used.
- Illumination section 12 directs light either from an observation light source 14 and a lens 16 or from an image capture light source 18 and a lens 20 as controlled by control logic circuitry (not shown in FIG. 3 ).
- a half-mirror 22 directs light from the appropriate source through a ring-slit diaphragm 24 and a lens 26 , to an apertured mirror 28 .
- Apertured mirror 28 directs the illumination light along axis O and toward the pupil for illuminating the retina of eye E.
- observation light source 14 is typically infrared (IR) light, to which eye E is insensitive.
- Image capture light source 18 may be a high-brightness source such as a xenon lamp, for example. Depending on the application, image capture light source 18 may be pulsed or strobed.
- Ring-slit diaphragm 24 has the characteristic functional arrangement shown in FIG. 4 .
- Light is transmitted through an inner ring 30 and is blocked at a middle section 32 and at an outer section 34 .
- inner ring 30 is directed into a pupil 36 of the patient as a ring 40 of illumination.
- apertured mirror 28 FIG. 3
- CCD charge coupled device
- fundus imaging appliance 220 optical components in one embodiment of the present invention.
- fundus imaging appliance 220 has an alignment section 160 , a cornea focusing section 180 , and a retina focusing section 192 .
- An optional display 260 such as a conventional type of CRT or LC display monitor, for example, can be used to display images obtained from sensor 146 or cornea camera 170 . This would be helpful, for example, for someone other than the patient to observe images obtained at different stages of focus or imaging operation.
- the above sequence of steps is, in broad outline, the procedure used for an operator-assisted fundus imaging apparatus.
- the various models and types of fundus imaging cameras currently available may provide a number of different utilities to support each step in the process. For example, a number of these apparatus provide automated alignment and/or automated focusing. Even with these utilities, however, these devices still require some level of operator interaction. It can be appreciated that there would be particular advantages to a fully automated fundus imaging apparatus, not requiring operator intervention once the patient is identified to the system and is seated.
- the present invention automates the sequence of steps outlined above in order to provide a fundus imaging apparatus that does not require operator interaction.
- the automated camera of the present invention is capable of executing steps that heretofore were performed by an operator.
- the patient must perform a small number of steps in order to facilitate alignment and focusing as well as to indicate readiness for imaging, as described subsequently.
- an initial step is a patient positioning step 310 .
- Fundus imaging appliance 220 of the present invention may assist the patient with a visual or verbal instruction to look into the device with the right or left eye.
- An optional indicator element 410 is an input device of some type that, in one embodiment, can detect the presence of the patient near or at the device. Indicator element 410 could include any of a number of types of sensing devices that require no direct interaction from the patient.
- indicator element 410 could be a switch that is located on or near the camera, operated by the patient to initiate operation or to otherwise indicate readiness for imaging. Or, in a kiosk arrangement or other arrangement that allows patient selection of a type of test, the function of indicator element 410 could be performed by a touchpad screen or menu selection as possible input devices, for example. At a minimum, the function of indicator element is to indicate to automated fundus imaging appliance 220 that the patient:
- Alignment step 320 is then initiated once the patient is in position. Alignment step 320 is carried out automatically, using positioning techniques and methods such as those described in U.S. Pat. No. 6,733,129.
- control logic processor 214 using image detection algorithms as known in the image processing arts, senses the position of the patient's pupil based on the image detected at cornea camera 170 .
- the patient may need to indicate that the target is in view, such as using a switch 416 or other input. Alternately, eye motion algorithms could be used to automatically ascertain patient fixation on the target.
- control logic processor 214 Based on the position of the pupil that is sensed, control logic processor 214 sends commands to motor assembly 408 , which acts as an alignment actuator to adjust the position of optical components until a suitable alignment positioning is achieved. Control logic processor 214 continues to monitor this alignment throughout subsequent steps, making adjustments as necessary.
- a cornea focusing step 330 follows, during which the cornea is brought into focus for cornea camera 170 .
- control logic processor 214 makes a number of additional adjustments based on the image detected at cornea camera 170 .
- information such as relative pupil size and color characteristics of the eye can be used to set illumination levels for the patient.
- a focus step 340 follows, during which a suitable retinal focus is achieved.
- control logic processor 214 causes the eye to be illuminated and detects the image feedback from sensor 146 . Based on the focus detection, control logic processor 214 sends commands to a focus motor 406 that, acting as a type of focusing actuator, adjusts the focus position of lenses 144 and 251 . Following this, imaging algorithms are used to determine focus, as is described subsequently. Control logic processor 214 may continue to check and monitor focus as necessary.
- Control logic processor 214 may instruct the patient to blink or may detect a blink event, then capture the retinal image at a suitable moment following this event.
- control logic processor to sense proper imaging conditions from cornea camera 170 and sensor 146 in a number of ways.
- the patient could even be provided with a control that enables the image to be taken when setup, alignment, and focus are achieved and the patient is ready. That is, using a camera analogy, the patient could be provided with shutter control to actually capture the image at the patient's command. However, image capture would be enabled only when conditions of alignment and focus are deemed suitable.
- focus detection mechanisms that could be employed for automated focus detection and response.
- Pupil tracking and pupil sizing algorithms could also be used in conjunction with fundus imaging appliance 220 , in order to make necessary adjustments for alignment and focus.
- Image data obtained from camera 170 , refreshed at a suitable rate for pupil tracking, is analyzed using any of a number of suitable algorithms for pupil tracking, such as any of the following, for example:
- Fundus imaging appliance 220 executes the basic steps shown in FIG. 7 automatically, with the option of patient involvement in one or more steps.
- the optimal size of light ring 40 ( FIG. 5 ) can be determined and a suitable light ring 40 provided, such as with a selection of apertures 412 and 414 in illumination section 112 ( FIG. 6 ).
- a liquid crystal light modulator could be used in the illumination path for programmable aperture sizing.
- Alignment section 160 provides aiming and accommodation of the patient's vision, in order to position the eye E favorably for fundus imaging in alignment step 320 of FIG. 7 .
- Alignment section 160 is shown in simplified form in FIG. 9A .
- the patient's eye is coarsely positioned by being placed against an eye holder 222 or a chin rest.
- An aiming target aperture 228 with an aiming target light source 162 is visible to the patient through beamsplitters 224 and 172 , mirror 174 , and a movable polarization beamsplitter 226 ( FIG. 6 ), providing collimated light.
- light source 162 is shown at one of its possible positions. As the simplified block diagram of FIG. 9A suggests, light source 162 can be disposed at any suitable position along the optical path.
- the beam diameter in one embodiment is about 5 mm.
- the collimated light is used to orient the eye of the patient to a position that provides visual accommodation. That is, when the patient views aiming target aperture 228 through lens 142 and a lens assembly 164 , the light entering eye E is substantially collimated.
- the alignment procedure along optical axis Oa sets the position of eye E along the z axis, and provides alignment positioning relative to the orthogonal x and y axes.
- the patient can indicate that the target is clearly visible, using a switch or other mechanism. This indicates that alignment is achieved and cornea centering and focus can be initiated.
- the center of the iris or pupil O 1 can be determined using image analysis software and can be compared with the center O 2 along the optical axis of a camera.
- pupil profiling light sources 176 When necessary to center the cornea, pupil profiling light sources 176 , near-IR sources in one embodiment, are first turned on to provide peripheral illumination to the cornea. The reflected light is then directed, through beamsplitters 172 and 166 and through lens or lens assembly 168 , to cornea camera 170 , which is optically conjugate to the cornea.
- Cornea camera 170 can be a relatively inexpensive imaging device, requiring only that it have sufficient resolution for focusing.
- cornea camera 170 is a CCD camera, model no. IK-52V manufactured by Toshiba.
- image analysis software in control logic processor 214 assesses the cornea centering, as described with reference to FIG. 9B , and adjusts the x and y position of optical assembly components by controlling a motor assembly 408 which serves as an actuator for obtaining alignment.
- focus cornea step 330 of FIG. 7 can be executed.
- optical components For cornea focus, optical components must be adjusted in the z direction.
- pupil profiling light sources 176 are then switched off and light sources 230 and 231 are alternately switched on and off.
- Light from light sources 230 and 231 goes through apertures 236 and 232 that are configured to provide the light for each focus indicator.
- Light sources 230 and 231 are oriented so that the optical axes along which their light is directed are not overlapping. Both light sources 230 and 231 point toward their respective openings in aperture 232 .
- a mechanical shuttering mechanism could alternately be used to alternate the light from light sources 230 and 231 instead of switching them alternately on and off.
- FIGS. 10A, 10B , 10 C, and 11 show how cornea focus is determined using a cornea focus detection section 450 .
- FIG. 11 shows the appearance of images 236 a ′ and 236 b ′ of aperture 236 in a field 171 of cornea camera 170 , as images 236 a ′ and 236 b ′ would appear when the cornea is not in focus, such as in the positions of FIGS. 10A and 10C , for example.
- FIG. 10B overlap occurs so that only a single image 236 a ′ and 236 b ′ is visible.
- Control logic processor 214 employs an imaging algorithm to determine whether there are two images 236 a ′ and 236 b ′ or a single image with image 236 a ′ overlapping 236 b ′. Based on the relative position and movement of images 236 a ′ and 236 b ′ with respect to each other, control logic processor 214 then controls motor assembly 408 appropriately to adjust the cornea focus. This requires movement of sensor 146 and related components according to the movement of images 236 a ′ and 236 b′.
- retinal focus can be obtained automatically using focus step 340 ( FIG. 7 ) of the apparatus of the present invention.
- images of an aperture are also used as feedback control signals, with a sequence similar to that followed for cornea focus.
- FIGS. 12A, 12B , and 12 C components of a retina focus detection section 452 of fundus imaging appliance 220 are shown.
- FIG. 12A shows the in-focus state.
- Light sources 240 and 242 are alternately switched on and off to image an aperture 246 onto the retina of the eye.
- Aperture 246 is imaged through an aperture 248 and lenses 250 and 142 .
- FIG. 13 there is shown a sensor field 147 for sensor 146 that is used for retinal focus and imaging.
- control logic processor 214 controls a motor 406 to adjust the focus position of both lenses 144 and 251 ( FIG. 6 ) in order to obtain focus.
- fundus imaging apparatus may repeat any portion or all of the sequence described with reference to steps 320 , 330 , 336 , and 340 in FIG. 7 .
- Control logic processor 214 may continuously check for cornea focus, for example, at various intervals and may recheck retinal focus immediately prior to imaging.
- control logic processor 214 enables an image of the retina to be obtained in image capture step 350 ( FIG. 7 ).
- image capture light source 114 is flashed on.
- Light from image capture light source 114 goes through a lens or lens assembly 178 , an aperture 412 , a lens 126 , and an aperture 414 and is reflected onto the optical axis O by apertured mirror 28 .
- Movable polarization beamsplitter 226 is shifted so that sensor 146 receives the retinal image.
- the patient can be prompted to operate fundus imaging appliance 220 .
- the patient can operate an optional switch 416 that acts as a type of shutter. Pressing switch 416 instructs control logic processor 214 that the patient is ready for imaging. Control logic processor may not enable imaging until cornea and retinal focus is achieved, however. A message can be displayed that instructs the patient to blink so that the image can be obtained after a short delay.
- Aiming target aperture 228 could be a display device that also provides a short message in addition to providing the fixation target, for example. Allowing the patient to indicate readiness has psychological advantages for the patient, since it gives the patient some amount of control for apparatus function and helps to ready the patient for the bright flash that occurs during imaging.
- a sensor 422 such as an inexpensive CCD or CMOS sensor, is positioned in the path provided by a beamsplitter 420 for sensing overlap of image of aperture 236 a ′ and 236 b ′ from the eye.
- This embodiment can be advantaged by providing separate sensing components for centering and focus.
- FIG. 15 Another alternate embodiment for cornea focus components is shown in FIG. 15 .
- a single LED 229 is needed. Since there are two openings in the aperture 232 , two bundles of light from the LED 229 reach the cornea surface and partially reflect back.
- Beamsplitter 420 provides reflected lights to a folding element 430 that sends two bundles of the reflected light to two sensor devices 432 and 434 separately.
- the light sensor devices 432 , 434 can be inexpensive CMOS or CCD sensors, for example, or some other type of position sensitive device. As with the embodiment of FIG. 14 , different sensors are used for centering and cornea focus with this arrangement.
- FIG. 22 Yet another alternate embodiment for cornea focus detection section 450 is shown in FIG. 22 .
- This embodiment uses a single light source 230 and a single sensor 422 .
- a pinhole aperture 236 must be optically centered with respect to sensor 422 , or in some other predefined position.
- Second aperture 233 requires only one opening rather than two with this embodiment.
- a beamsplitter 420 provides the illumination from light source 230 to a lens or lens assembly 234 and to another beamsplitter 166 that directs this illumination toward the cornea. Beamsplitter 166 directs the reflected image through a lens 168 and to a cornea camera 170 for focus assessment.
- Good calibration is needed so that the detected image of pinhole aperture 236 is centered at sensor 422 , or in some other predefined position with the cornea in focus.
- FIG. 23 Yet another alternate embodiment for cornea focus is shown in FIG. 23 .
- This embodiment adds a spatial light modulator 195 , such as a transmissive liquid crystal (LC) device, or other type of electro-optical or electromechanical device employed as a type of shuttering mechanism.
- Spatial light modulator 195 is used to alternate light from light source 230 to different openings in aperture 232 .
- spatial light modulator 195 is energized, only one opening in aperture 232 receives light at a time.
- Two images of aperture 236 are received on camera 170 , in an alternating sequence.
- An auxiliary sensor 440 obtains, through a beamsplitter 442 , images of aperture 246 a ′ and 246 b ′ as was described with reference to FIG. 13 .
- Auxiliary sensor 440 may be an inexpensive sensor, such as a CCD or CMOS device or some other light-position sensing component.
- a polarizer 436 polarizes the light that is alternately emitted from light sources 240 , 242 .
- An analyzer 438 is positioned in front of auxiliary sensor 440 and is oriented with its transmission axis orthogonal to that of polarizer 436 in order to block reflected light from the lens surfaces and cornea of the eye.
- Light sources 240 , 242 are oriented to direct light through portions of aperture 248 and arranged so that two bundles of light do not overlap. This creates a cross-talk free condition for the light from light sources 240 and 242 .
- a movable mirror 227 enables these components to be switched into the optical path when needed. With this embodiment, retina focus can be obtained quickly, without the need to employ a higher-resolution imaging sensor 146 .
- FIG. 17 there is shown another alternate embodiment for obtaining retinal focus.
- a single light source 240 is used, emitting light that is polarized by polarizer 436 .
- Analyzer 438 is positioned in front of auxiliary sensor 440 and has its transmission axis perpendicular to that of polarizer 436 .
- a prism pair 444 generates two illumination beams from light source 240 . The lights exiting from the prism pair 444 point to different directions and do not overlap.
- FIG. 18 shows a sensor field 446 during an out-of-focus condition of the retina; here, there are two images of aperture 246 a ′ and 246 b ′ that display.
- FIG. 17 has the speed and cost advantages described with reference to the embodiment of FIG. 16 and requires one fewer light source.
- FIG. 20 there is shown yet another embodiment for retinal focus.
- a pair of light sources is formed by directing light from light source 240 into two optical fibers 448 .
- the lights exiting from the fibers point to different directions and do not overlap.
- FIG. 21 there is shown the arrangement of images formed from on sensor field 446 from the pair of optical fibers 448 using the embodiment of FIG. 20 .
- a spatial light modulator 435 such as a transmissive LC device, is positioned as a shuttering mechanism for alternating the light from light source 240 through different portions of aperture 248 . Alternate components could be used to provide this same shuttering action. With this embodiment, only one hole in aperture 248 provides light at one time. Sensor 440 detects two images of aperture 246 at separate times. Thus, this arrangement senses focus in a manner similar to embodiments using multiple light sources.
- fundus imaging apparatus 220 of the present invention may have some way to detect that the patient has approached to a point near the device.
- Various types of indicator elements 410 could be used to detect the proximity of a patient, including detectors and sensors from Sick Incorporated, Minneapolis, Minn., for example.
- An optional camera could also be used, supported by image processing software that detects the image of a person.
- the presence of the patient may be used, for example, as part of an energy-saving system, to initiate full power-up from a “power-save” state of fundus imaging apparatus 220 in readiness for performing the setup and imaging operations described with reference to FIG. 7 .
- the apparatus of the present invention is advantaged in its capability to obtain retinal images in an automated fashion, requiring no interaction or intervention by an operator.
- This also makes fundus imaging appliance 220 suitable for self-use by a patient.
- Fundus imaging appliance 220 can be installed in a PCP office or lab facility, or could even be installed in a kiosk enclosure or other environment outside of a conventional medical setting. Where instructions might be helpful or necessary, fundus imaging apparatus 220 may display instructions to the patient or may provide audible instructions using optional speakers, for example.
- fundus imaging appliance 220 provides a fundus imaging apparatus that requires no operator, allows compact packaging, and may not require dilation of the pupil for most patients.
- fundus imaging appliance 220 is primarily intended to provide basic fundus imaging that can be inexpensively performed at the office of a PCP or other non-specialist site. Thus, more advanced imaging features and functions are omitted from this description of fundus imaging appliance 220 . However, the same components and methods for automating setup and focus functions could also be applied to a more sophisticated imaging device.
- the various light sources used within fundus imaging appliance 220 allow a number of optional types.
- Sensors and CCD devices could be any of a number of different types.
- an alternate embodiment for illumination directs light from a light source 294 through a fiber optic ring 292 . This type of arrangement could be beneficial for optimizing illumination brightness and direction.
- cornea camera 170 and sensor 146 Although the resolution and overall image quality requirements for cornea camera 170 and sensor 146 are quite different, a single CCD array could be used for both cornea camera 170 and sensor 146 , switched between these functions, using techniques well known in the imaging arts. Various types of reference locators could be used for assisting in the initial positioning of the patient. The patient is preferably seated; however, imaging could be obtained from a patient in some other position.
Abstract
An apparatus for obtaining a retinal image of an eye has a control logic processor for executing a sequence of operations for obtaining the image. A visual target orients the eye of a patient when viewed. An indicator element provides a signal that indicates that the patient is in position. A cornea focus detection section indicates cornea focus, in cooperation with the control logic processor. An alignment actuator aligns the optical path according to a signal obtained from the cornea focus detection section. A retina focus detection section detects retina focus in cooperation with the control logic processor. A focusing actuator is controlled by instructions from the control logic processor according to a signal obtained from the retina focus detection section. An image capture light source is energized by the control logic processor for illuminating the retina.
Description
- This is a divisional of commonly assigned application U.S. Ser. No. 11/196,824, entitled “AUTOMATED FUNDUS IMAGING SYSTEM”, filed on Aug. 3, 2005 in the names of Liang et al, and which is assigned to the assignee of this application.
- This invention generally relates to electronic imaging apparatus for fundus imaging and more particularly relates to an improved fundus imaging apparatus for automated imaging without operator intervention.
- Fundus camera imaging is acknowledged to be an important diagnostic tool for detection of various conditions affecting the eye, including diabetic retinopathy and macular degeneration. Various embodiments of fundus imaging apparatus are disclosed, for example in U.S. Pat. Nos. 5,713,047 (Kohayakawa); 5,943,116 (Zeimer); 5,572,266 (Ohtsuka); 4,838,680 (Nunokawa); 6,546,198 (Ohtsuka); and 6,636,696 (Saito).
- While conventional fundus imaging apparatus require manual operation, there has been considerable effort expended toward automating specific functions of these imaging apparatus. For example, U.S. Pat. No. 6,296,358 (Cornsweet et al.) discloses an automated sequence that is executed for pupil alignment and focusing. U.S. Pat. No. 4,732,466 (Humphrey) discloses an automated focus mechanism for a fundus imaging apparatus. U.S. Pat. No. 6,733,129 (Masaki) discloses an automatic alignment sequence using a feedback loop with a light beam projected onto the cornea, a sensor for sensing reflected light, and a series of motors for effecting alignment adjustment. U.S. Pat. No. 6,705,726 (Tanassi et al.) discloses a multi-function optical imaging apparatus with a number of automation features in various subsystems. U.S. Pat. No. 6,830,336 (Fransen) discloses automation of the sequencing of images for a patient, in order to obtain a complete series of fundus images once the patient is properly positioned and suitable focus has been achieved.
- While these patents attest to continuous improvements in fundus camera design, there are still significant hurdles to widespread acceptance and usability of these devices. Among disadvantages noted with current apparatus are relative complexity of operation. This remains the case even with improvements that automate focus and alignment operations, as noted above.
- A number of fundus imaging apparatus are designed for the more limited function of diabetic retinopathy screening. These devices are intended to be used by relatively unskilled operators who receive minimal training. For example, these lower cost fundus imaging apparatus are intended to be installed at a personal care physician (PCP) office or in medical test lab collection facility, rather than at a specialist's facility. The intent is to have these apparatus operated by a clerical staff of medical technicians at the PCP office of other site, to obtain images for first-level screening. In order to provide simple operation, these fundus imaging apparatus are designed with an operator interface that provides controls for operation, with operator feedback as well as automated response to events such as patient head and eye movement.
- While recent designs appear to offer better usability and performance of these systems, however, there remains considerable room for improvement. One inherent problem relates to the operator learning curve. While a number of these systems offer ease of operation, they still require some amount of practice. An operator working with a fundus imaging apparatus can achieve some facility after working continuously with such a system for an hour or so, particularly under trained guidance. However, only a small percentage of patients in the PCP environment will require this type of screening. Operating this equipment once or twice a day may not give an operator enough practice to achieve a level of mastery of the apparatus. Moreover, problems of staff scheduling and turnover may make it impractical for a facility to have only a single staff member trained to use this apparatus. Thus, even though newer fundus imaging apparatus may be easier to operate, there are inherent barriers to taking advantage of easier operation. In order to be economical, classroom or individual training is impractical. Instead, operator training must be delivered in electronic form, such as by CD or over the Internet, or by means of a manual or quick-reference guide. Even using on-screen prompts, it would be very difficult to provide effective interactive operator assistance during imaging.
- There is a need for an improved fundus imaging apparatus that is essentially operable without operator intervention. This would make it possible, for example, to have an imaging system that is automated or is even operable by patients themselves, with minimal setup instruction from PCP staff members.
- Briefly, according to one aspect of the present invention, an apparatus for obtaining a retinal image from an eye, comprises:
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- a) a control logic processor for executing a sequence of operations for obtaining the image;
- b) a visual target for orienting the eye of a patient when the target viewed by the patient;
- c) an indicator element for providing a signal that indicates that the patient is in position for imaging;
- d) a cornea focus detection section for providing an indication of cornea focus, in cooperation with the control logic processor;
- e) an alignment actuator for aligning the optical path of the apparatus according to a signal obtained from the cornea focus detection section;
- f) a retina focus detection section for detecting retina focus in cooperation with the control logic processor;
- g) a focusing actuator controlled by instructions from the control logic processor according to a signal obtained from the retina focus detection section; and
- h) an image capture light source energized by the control logic processor for illuminating the retina for image capture.
- It is a feature of the present invention that it provides an automated apparatus that does not require operator intervention for normal operation.
- It is an advantage of the present invention that it can allow the patient to have an enhanced sense of control over the imaging process, without requiring operational expertise or training of the patient.
- These and other objects, features, and advantages of the present invention will become apparent to those skilled in the art upon a reading of the following detailed description when taken in conjunction with the drawings wherein there is shown and described an illustrative embodiment of the invention.
- While the specification concludes with claims particularly pointing out and distinctly claiming the subject matter of the present invention, it is believed that the invention will be better understood from the following description when taken in conjunction with the accompanying drawings, wherein:
-
FIG. 1 is a schematic block diagram of a fundus imaging apparatus; -
FIG. 2 is a schematic block diagram showing subsystem components of the imaging apparatus of the present invention; -
FIG. 3 is a schematic block diagram showing the overall arrangement of illumination apparatus components within a conventional fundus imaging apparatus; -
FIG. 4 is a plan view of a ring-slit diaphragm used in a conventional fundus imaging apparatus; -
FIG. 5 is a plan view representation of the ring of illumination applied to the pupil of a patient in a conventional apparatus; -
FIG. 6 is a schematic block diagram of a fundus imaging apparatus in one embodiment; -
FIG. 7 is a process flow diagram showing the basic steps used for obtaining a retinal image using the imaging system of the present invention; -
FIGS. 8A, 8B , and 8C are plan views showing an arrangement of operator interface display screens for a conventional fundus imaging apparatus; -
FIG. 9A is a schematic block diagram showing alignment apparatus according to one embodiment; -
FIG. 9B is a plan view showing an arrangement of illumination rings used for cornea focus; -
FIGS. 10A, 10B , and 10C are side view block diagrams showing cornea focus in one embodiment; -
FIG. 11 is a plan view of the sensor field for cornea focus; -
FIGS. 12A, 12B , and 12C are side view block diagrams showing retina focus in one embodiment; -
FIG. 13 is a plan view of the sensor field for retina focus; -
FIG. 14 is a schematic diagram showing how cornea focus is achieved in one embodiment; -
FIG. 15 is a schematic diagram showing how cornea focus is achieved in another embodiment; -
FIG. 16 is a schematic diagram showing how retinal focus can be obtained in one embodiment; -
FIG. 17 is a schematic diagram showing how retinal focus can be obtained in an alternate embodiment; -
FIG. 18 is a plan view of the sensor field for a retina out-of-focus condition in one embodiment; -
FIG. 19 is a plan view of the sensor field for the retina in-focus condition in one embodiment; -
FIG. 20 is a schematic diagram showing how retinal focus can be obtained in an alternate embodiment; -
FIG. 21 is a plan view showing the sensor field for a retina out-of-focus condition in the embodiment ofFIG. 20 ; -
FIG. 22 is a schematic view of components for cornea focus in an alternate embodiment; -
FIG. 23 is a schematic view of components for cornea focus in another alternate embodiment; -
FIG. 24 is a schematic view of components for retinal focus in an alternate embodiment; and -
FIG. 25 is a block diagram showing a fiber-optic illumination ring in one embodiment. - The present description is directed in particular to elements forming part of, or cooperating more directly with, apparatus in accordance with the invention. It is to be understood that elements not specifically shown or described may take various forms well known to those skilled in the art.
- System Configuration
- Referring to
FIG. 1 , there is shown a conventionalfundus imaging system 100 for obtaining an image from apatient 402. To supportfundus imaging system 100, acontrol workstation 210 has adisplay 138, akeyboard 212, and acontrol logic processor 214 for providing control logic and interface functions for anoperator 400. Imaging functions are provided by optical, electro-optical, and electronic components within afundus imaging appliance 220. Anetwork 216 allows communication betweenfundus imaging system 100 and processing and storage devices at other networked sites. Usingnetwork 216, for example, fundus images obtained byfundus imaging system 100 can be uploaded to other sites, such as to sites where diagnostic assessment is performed remotely. Alternately, software, instructions, or other data could be downloaded from other networked sites tofundus imaging system 100 or to controlworkstation 210. - There are a number of alternate embodiments possible based on the overall arrangement of
FIG. 1 . For example, the function ofcontrol logic processor 214 may be performed by logic components withinfundus imaging appliance 220, rather than by a separately packaged processor, as shown inFIG. 1 . Thus, camera interface devices, operating controls, and display could be located on the body offundus imaging appliance 220 itself, for example. Operator interface functions provided bydisplay 138 andkeyboard 212 could be combined in a touchscreen console, for example. The connection tonetwork 216 may be a standard Ethernet connection, a dedicated network telecommunications connection, or a dial-up modem. In one embodiment,network 216 allows wireless connection. Alternately, the connection to network 216 may be dispensed with altogether, such thatimaging appliance 220 records fundus imaging data onto a data storage medium such as a removable storage medium, which could be as a magnetic, electronic, or optical storage medium, for example. -
Fundus Imaging Appliance 220 Block Diagram - Referring to
FIG. 2 , there is shown a high-level schematic block diagram of key subsystems offundus imaging appliance 220. The relative position of eye E is shown on an optical axis O. Alignment of illumination and imaging optics and delivery of light to the eye is performed by anillumination section 112. Animage capture section 102 then cooperates withillumination section 112 components to obtain the retinal images from eye E. Acontrol logic processor 104 withinfundus imaging appliance 220controls illumination section 112 andimage capture section 102 components to maintain proper alignment relative to eye E and provide the optimal lighting characteristics for retinal imaging.Control logic processor 104 also executes pupil-tracking algorithms and provides signals for controlling imaging operation. Operator commands at control workstation 210 (FIG. 1 ) are provided to controllogic processor 104 for manipulating component positioning, illumination, and imaging functions. - Illumination Arrangement
- Referring to
FIG. 3 , there is shown a schematic diagram of afundus imaging apparatus 10 in which aconventional illumination section 12 is used. The patient's eye E is positioned along an optical axis O using an alignment subsystem, not shown inFIG. 3 , but described subsequently.Illumination section 12 directs light either from anobservation light source 14 and alens 16 or from an image capturelight source 18 and alens 20 as controlled by control logic circuitry (not shown inFIG. 3 ). A half-mirror 22 directs light from the appropriate source through a ring-slit diaphragm 24 and alens 26, to anapertured mirror 28.Apertured mirror 28 directs the illumination light along axis O and toward the pupil for illuminating the retina of eye E. Depending on the use offundus imaging apparatus 10 at any one time, either observationlight source 14 or image capturelight source 18 are activated.Observation light source 14 is typically infrared (IR) light, to which eye E is insensitive. Image capturelight source 18, on the other hand, may be a high-brightness source such as a xenon lamp, for example. Depending on the application, image capturelight source 18 may be pulsed or strobed. - Ring-
slit diaphragm 24 has the characteristic functional arrangement shown inFIG. 4 . Light is transmitted through aninner ring 30 and is blocked at amiddle section 32 and at anouter section 34. As is shown in the received illumination ring ofFIG. 5 ,inner ring 30 is directed into apupil 36 of the patient as aring 40 of illumination. To obtain the retinal image, apertured mirror 28 (FIG. 3 ) has an aperture suitably centered about optical axis O to allow light that has been reflected from the retina of eye E and directed throughlenses sensor 46, such as a charge coupled device (CCD). - Referring to
FIG. 6 , there is shown a more detailed block diagram offundus imaging appliance 220 optical components in one embodiment of the present invention. In addition toillumination section 112 described above,fundus imaging appliance 220 has analignment section 160, acornea focusing section 180, and aretina focusing section 192. Anoptional display 260, such as a conventional type of CRT or LC display monitor, for example, can be used to display images obtained fromsensor 146 orcornea camera 170. This would be helpful, for example, for someone other than the patient to observe images obtained at different stages of focus or imaging operation. - Operator Steps for Imaging
- In order to better understand the apparatus and method of the present invention, it is instructive to briefly summarize the sequence of operator procedures used for obtaining a retinal image with conventional fundus imaging cameras. An outline of these basic procedures is as follows:
-
- 1. Position the patient at the imaging apparatus. For most devices, a chin rest, forehead support, and other features are provided to help get the patient into position for imaging.
- 2. Make initial settings. This step may vary significantly from one manufacturer's camera to the next. Initial settings may include filter placement in or out of the optical path or selection of suitable focus lenses based on the state of the patient's vision (for a high degree of near-sightedness, for example). Brightness settings may also be made, based on patient age or other characteristics.
- 3. Center the pupil in the object field of the camera. This step requires x-y coordinate positioning the camera so that the patient's pupil is centered. With some types of fundus imaging devices, the operator performs this adjustment using a computer mouse, joystick or similar control to achieve pupil centering. For a conventional fundus imaging device,
FIGS. 8A and 8B show the arrangement of display screens on anoperator interface display 138. A thumbnail, black andwhite image 250 of eye E appears, as shown inFIG. 8A . The operator uses the mouse, joystick, or other suitable pointing mechanism to manipulate the position of acursor 261, centering it within the image of the pupil inimage 250. Motion control logic infundus imaging appliance 220 responds by aligning eye E with the optical axis of the apparatus. The operator can further “fine-tune” the alignment adjustment using any of various command entry tools to achieve a pupil-alignedimage 252, as shown inFIG. 8B . With this procedure, the operator is ready to obtain suitable alignment of the pupil with respect to the optical axis. - 4. Achieve coarse focus of the retina. This may be obtained, for example, by sliding the camera body forward or backward. Typically, an infrared viewing source is used to guide focus operation. Various cameras display focus indicators to the operator, such as a pair of bright spots that overlap when approximate focus is achieved. As shown in
FIG. 8C , the corneal image now becomes athumbnail image 262 and a full-size image 254 provides a monochrome preview image ondisplay 138. - 5. Achieve fine focus of the retina. Fine focus is typically obtained by adjustment of optics within the imaging apparatus itself.
- 6. Capture the retinal image. The operator obtains the retinal image once fine focus of the retina is achieved. Typically, the operator instructs the patient to blink, then obtains the image a moment afterward, when the eye is again fixated along the axis.
- The above sequence of steps is, in broad outline, the procedure used for an operator-assisted fundus imaging apparatus. The various models and types of fundus imaging cameras currently available may provide a number of different utilities to support each step in the process. For example, a number of these apparatus provide automated alignment and/or automated focusing. Even with these utilities, however, these devices still require some level of operator interaction. It can be appreciated that there would be particular advantages to a fully automated fundus imaging apparatus, not requiring operator intervention once the patient is identified to the system and is seated.
- Automated Steps for Imaging
- The present invention automates the sequence of steps outlined above in order to provide a fundus imaging apparatus that does not require operator interaction. Once the patient is seated or otherwise positioned with the eye to be imaged placed reasonably close to the objective lens, the automated camera of the present invention is capable of executing steps that heretofore were performed by an operator. The patient must perform a small number of steps in order to facilitate alignment and focusing as well as to indicate readiness for imaging, as described subsequently.
- Referring to
FIG. 7 , there is shown a flow diagram of the steps as performed by automatedfundus imaging appliance 220 of the present invention as shown inFIG. 6 . In anautomated imaging sequence 300, an initial step is apatient positioning step 310.Fundus imaging appliance 220 of the present invention may assist the patient with a visual or verbal instruction to look into the device with the right or left eye. Anoptional indicator element 410 is an input device of some type that, in one embodiment, can detect the presence of the patient near or at the device.Indicator element 410 could include any of a number of types of sensing devices that require no direct interaction from the patient. Alternately, in one embodiment,indicator element 410 could be a switch that is located on or near the camera, operated by the patient to initiate operation or to otherwise indicate readiness for imaging. Or, in a kiosk arrangement or other arrangement that allows patient selection of a type of test, the function ofindicator element 410 could be performed by a touchpad screen or menu selection as possible input devices, for example. At a minimum, the function of indicator element is to indicate to automatedfundus imaging appliance 220 that the patient: -
- (i) is in proper position, that is, in position to see the required target; and
- (ii) is ready to proceed with image capture.
- An
alignment step 320 is then initiated once the patient is in position.Alignment step 320 is carried out automatically, using positioning techniques and methods such as those described in U.S. Pat. No. 6,733,129. Inalignment step 320,control logic processor 214, using image detection algorithms as known in the image processing arts, senses the position of the patient's pupil based on the image detected atcornea camera 170. The patient may need to indicate that the target is in view, such as using aswitch 416 or other input. Alternately, eye motion algorithms could be used to automatically ascertain patient fixation on the target. Based on the position of the pupil that is sensed,control logic processor 214 sends commands tomotor assembly 408, which acts as an alignment actuator to adjust the position of optical components until a suitable alignment positioning is achieved.Control logic processor 214 continues to monitor this alignment throughout subsequent steps, making adjustments as necessary. Acornea focusing step 330 follows, during which the cornea is brought into focus forcornea camera 170. - In an adjust settings step 336,
control logic processor 214 makes a number of additional adjustments based on the image detected atcornea camera 170. For example, information such as relative pupil size and color characteristics of the eye can be used to set illumination levels for the patient. - A
focus step 340 follows, during which a suitable retinal focus is achieved. For this step,control logic processor 214 causes the eye to be illuminated and detects the image feedback fromsensor 146. Based on the focus detection,control logic processor 214 sends commands to afocus motor 406 that, acting as a type of focusing actuator, adjusts the focus position oflenses Control logic processor 214 may continue to check and monitor focus as necessary. - Once focus is achieved, an
image capture step 350 can be executed.Control logic processor 214 may instruct the patient to blink or may detect a blink event, then capture the retinal image at a suitable moment following this event. - There are a number of options available for executing the steps of
automated imaging sequence 300. For example, numerous types of image detection algorithms exist, enabling control logic processor to sense proper imaging conditions fromcornea camera 170 andsensor 146 in a number of ways. In place ofindicator element 410, the patient could even be provided with a control that enables the image to be taken when setup, alignment, and focus are achieved and the patient is ready. That is, using a camera analogy, the patient could be provided with shutter control to actually capture the image at the patient's command. However, image capture would be enabled only when conditions of alignment and focus are deemed suitable. There are a number of types of focus detection mechanisms that could be employed for automated focus detection and response. - Pupil tracking and pupil sizing algorithms could also be used in conjunction with
fundus imaging appliance 220, in order to make necessary adjustments for alignment and focus. Image data obtained fromcamera 170, refreshed at a suitable rate for pupil tracking, is analyzed using any of a number of suitable algorithms for pupil tracking, such as any of the following, for example: -
- (i) center of mass calculation that determines the center of the pupil opening and uses a fixed or adjustable diameter as a pupil shape;
- (ii) threshold evaluation that automatically determines a threshold source image value representing pupil area and uses that threshold to trace out the pupil outline; this method could alternately use a median filter for smoothing;
- (iii) threshold evaluation combined with a connected components analysis that identifies the pixel area;
- (iv) threshold evaluation that locates the center and bounding box of the pupil region; or
- (v) center of shape detection algorithms.
-
Fundus imaging appliance 220 executes the basic steps shown inFIG. 7 automatically, with the option of patient involvement in one or more steps. Once the pupil size is detected, the optimal size of light ring 40 (FIG. 5 ) can be determined and asuitable light ring 40 provided, such as with a selection ofapertures FIG. 6 ). A liquid crystal light modulator could be used in the illumination path for programmable aperture sizing. - Eye Alignment
-
Alignment section 160 provides aiming and accommodation of the patient's vision, in order to position the eye E favorably for fundus imaging inalignment step 320 ofFIG. 7 .Alignment section 160 is shown in simplified form inFIG. 9A . The patient's eye is coarsely positioned by being placed against aneye holder 222 or a chin rest. An aimingtarget aperture 228 with an aiming targetlight source 162, such as an LED or other visible light source, is visible to the patient throughbeamsplitters mirror 174, and a movable polarization beamsplitter 226 (FIG. 6 ), providing collimated light. - In
FIG. 6 ,light source 162 is shown at one of its possible positions. As the simplified block diagram ofFIG. 9A suggests,light source 162 can be disposed at any suitable position along the optical path. The beam diameter in one embodiment is about 5 mm. The collimated light is used to orient the eye of the patient to a position that provides visual accommodation. That is, when the patient views aimingtarget aperture 228 throughlens 142 and alens assembly 164, the light entering eye E is substantially collimated. Relative to the coordinate axes shown inFIG. 6 , the alignment procedure along optical axis Oa sets the position of eye E along the z axis, and provides alignment positioning relative to the orthogonal x and y axes. - For a patient operated system, the patient can indicate that the target is clearly visible, using a switch or other mechanism. This indicates that alignment is achieved and cornea centering and focus can be initiated.
- Cornea Centering and Focus
- Once alignment of eye E is achieved, centering of the cornea relative to optical axis O is necessary. Referring to
FIG. 9B , the principle of centering is shown. The center of the iris or pupil O1 can be determined using image analysis software and can be compared with the center O2 along the optical axis of a camera. - When necessary to center the cornea, pupil profiling
light sources 176, near-IR sources in one embodiment, are first turned on to provide peripheral illumination to the cornea. The reflected light is then directed, throughbeamsplitters lens assembly 168, tocornea camera 170, which is optically conjugate to the cornea.Cornea camera 170 can be a relatively inexpensive imaging device, requiring only that it have sufficient resolution for focusing. In one embodiment, for example,cornea camera 170 is a CCD camera, model no. IK-52V manufactured by Toshiba. - Once the image signal about the cornea is obtained, image analysis software in
control logic processor 214 assesses the cornea centering, as described with reference toFIG. 9B , and adjusts the x and y position of optical assembly components by controlling amotor assembly 408 which serves as an actuator for obtaining alignment. - Following centering,
focus cornea step 330 ofFIG. 7 can be executed. For cornea focus, optical components must be adjusted in the z direction. To focus the cornea once it is centered, pupil profilinglight sources 176 are then switched off andlight sources light sources apertures Light sources light sources aperture 232. A mechanical shuttering mechanism (not shown) could alternately be used to alternate the light fromlight sources lens 234 operates to imageaperture 236 onto the cornea.FIGS. 10A, 10B , 10C, and 11 show how cornea focus is determined using a corneafocus detection section 450.FIG. 11 shows the appearance ofimages 236 a′ and 236 b′ ofaperture 236 in afield 171 ofcornea camera 170, asimages 236 a′ and 236 b′ would appear when the cornea is not in focus, such as in the positions ofFIGS. 10A and 10C , for example. When the cornea is in focus, as shown inFIG. 10B , overlap occurs so that only asingle image 236 a′ and 236 b′ is visible.Control logic processor 214 employs an imaging algorithm to determine whether there are twoimages 236 a′ and 236 b′ or a single image withimage 236 a′ overlapping 236 b′. Based on the relative position and movement ofimages 236 a′ and 236 b′ with respect to each other, controllogic processor 214 then controlsmotor assembly 408 appropriately to adjust the cornea focus. This requires movement ofsensor 146 and related components according to the movement ofimages 236 a′ and 236 b′. - Retinal Focus
- Once cornea centering and focus is achieved, retinal focus can be obtained automatically using focus step 340 (
FIG. 7 ) of the apparatus of the present invention. To obtain retinal focus, images of an aperture are also used as feedback control signals, with a sequence similar to that followed for cornea focus. Referring toFIGS. 12A, 12B , and 12C, components of a retinafocus detection section 452 offundus imaging appliance 220 are shown.FIG. 12A shows the in-focus state.Light sources aperture 246 onto the retina of the eye.Aperture 246 is imaged through anaperture 248 andlenses FIG. 13 , there is shown asensor field 147 forsensor 146 that is used for retinal focus and imaging. Two separate images ofaperture 246 a′ and 246 b′ appear insensor field 147 during an out-of-focus condition. At focus (FIG. 12A ), the two images ofaperture 246 a′ and 246 b′ overlap. Based on the position and relative movement of images ofaperture 246 a′ and 246 b′,control logic processor 214 controls amotor 406 to adjust the focus position of bothlenses 144 and 251 (FIG. 6 ) in order to obtain focus. - Once retinal focus is achieved, fundus imaging apparatus may repeat any portion or all of the sequence described with reference to
steps FIG. 7 .Control logic processor 214 may continuously check for cornea focus, for example, at various intervals and may recheck retinal focus immediately prior to imaging. - Image Capture
- Once proper conditions of alignment and focus have been obtained,
control logic processor 214 enables an image of the retina to be obtained in image capture step 350 (FIG. 7 ). For this step, an image capturelight source 114 is flashed on. Light from image capturelight source 114 goes through a lens orlens assembly 178, anaperture 412, alens 126, and anaperture 414 and is reflected onto the optical axis O byapertured mirror 28.Movable polarization beamsplitter 226 is shifted so thatsensor 146 receives the retinal image. - The patient can be prompted to operate
fundus imaging appliance 220. For example, the patient can operate anoptional switch 416 that acts as a type of shutter. Pressingswitch 416 instructscontrol logic processor 214 that the patient is ready for imaging. Control logic processor may not enable imaging until cornea and retinal focus is achieved, however. A message can be displayed that instructs the patient to blink so that the image can be obtained after a short delay. Aimingtarget aperture 228 could be a display device that also provides a short message in addition to providing the fixation target, for example. Allowing the patient to indicate readiness has psychological advantages for the patient, since it gives the patient some amount of control for apparatus function and helps to ready the patient for the bright flash that occurs during imaging. - Alternate Embodiments for Cornea Focus
- Referring to
FIG. 14 , there is shown one alternate embodiment for cornea focus components. In this embodiment, asensor 422, such as an inexpensive CCD or CMOS sensor, is positioned in the path provided by abeamsplitter 420 for sensing overlap of image ofaperture 236 a′ and 236 b′ from the eye. This embodiment can be advantaged by providing separate sensing components for centering and focus. - Another alternate embodiment for cornea focus components is shown in
FIG. 15 . Here, only asingle LED 229 is needed. Since there are two openings in theaperture 232, two bundles of light from theLED 229 reach the cornea surface and partially reflect back.Beamsplitter 420 provides reflected lights to afolding element 430 that sends two bundles of the reflected light to twosensor devices light sensor devices FIG. 14 , different sensors are used for centering and cornea focus with this arrangement. - Yet another alternate embodiment for cornea
focus detection section 450 is shown inFIG. 22 . This embodiment uses a singlelight source 230 and asingle sensor 422. Apinhole aperture 236 must be optically centered with respect tosensor 422, or in some other predefined position.Second aperture 233 requires only one opening rather than two with this embodiment. Abeamsplitter 420 provides the illumination fromlight source 230 to a lens orlens assembly 234 and to anotherbeamsplitter 166 that directs this illumination toward the cornea.Beamsplitter 166 directs the reflected image through alens 168 and to acornea camera 170 for focus assessment. When using onlylight source 230 and not two light sources as shown in other embodiments, there is no need for switching the illumination on and off. Good calibration is needed so that the detected image ofpinhole aperture 236 is centered atsensor 422, or in some other predefined position with the cornea in focus. - Yet another alternate embodiment for cornea focus is shown in
FIG. 23 . This embodiment adds a spatiallight modulator 195, such as a transmissive liquid crystal (LC) device, or other type of electro-optical or electromechanical device employed as a type of shuttering mechanism. Spatiallight modulator 195 is used to alternate light fromlight source 230 to different openings inaperture 232. When spatiallight modulator 195 is energized, only one opening inaperture 232 receives light at a time. Two images ofaperture 236 are received oncamera 170, in an alternating sequence. - Alternate Embodiment for Retinal Focus
- Referring to
FIG. 16 , there is shown an alternate embodiment for obtaining retinal focus. Anauxiliary sensor 440 obtains, through abeamsplitter 442, images ofaperture 246 a′ and 246 b′ as was described with reference toFIG. 13 .Auxiliary sensor 440 may be an inexpensive sensor, such as a CCD or CMOS device or some other light-position sensing component. Apolarizer 436 polarizes the light that is alternately emitted fromlight sources analyzer 438 is positioned in front ofauxiliary sensor 440 and is oriented with its transmission axis orthogonal to that ofpolarizer 436 in order to block reflected light from the lens surfaces and cornea of the eye.Light sources aperture 248 and arranged so that two bundles of light do not overlap. This creates a cross-talk free condition for the light fromlight sources movable mirror 227 enables these components to be switched into the optical path when needed. With this embodiment, retina focus can be obtained quickly, without the need to employ a higher-resolution imaging sensor 146. - Referring to
FIG. 17 , there is shown another alternate embodiment for obtaining retinal focus. Here, a singlelight source 240 is used, emitting light that is polarized bypolarizer 436.Analyzer 438 is positioned in front ofauxiliary sensor 440 and has its transmission axis perpendicular to that ofpolarizer 436. Aprism pair 444 generates two illumination beams fromlight source 240. The lights exiting from theprism pair 444 point to different directions and do not overlap.FIG. 18 shows asensor field 446 during an out-of-focus condition of the retina; here, there are two images ofaperture 246 a′ and 246 b′ that display. When the retina is in focus, images ofaperture 246 a′ and 246 b′ overlap, as shown in the plan view ofFIG. 19 . The embodiment ofFIG. 17 has the speed and cost advantages described with reference to the embodiment ofFIG. 16 and requires one fewer light source. - Referring to
FIG. 20 , there is shown yet another embodiment for retinal focus. Here, a pair of light sources is formed by directing light fromlight source 240 into twooptical fibers 448. The lights exiting from the fibers point to different directions and do not overlap. Referring toFIG. 21 , there is shown the arrangement of images formed from onsensor field 446 from the pair ofoptical fibers 448 using the embodiment ofFIG. 20 . - Referring to
FIG. 24 , there is shown yet another embodiment for retinal focus. A spatiallight modulator 435, such as a transmissive LC device, is positioned as a shuttering mechanism for alternating the light fromlight source 240 through different portions ofaperture 248. Alternate components could be used to provide this same shuttering action. With this embodiment, only one hole inaperture 248 provides light at one time.Sensor 440 detects two images ofaperture 246 at separate times. Thus, this arrangement senses focus in a manner similar to embodiments using multiple light sources. - Sensing the Patient
- In order to operate in a highly automated fashion,
fundus imaging apparatus 220 of the present invention may have some way to detect that the patient has approached to a point near the device. Various types ofindicator elements 410 could be used to detect the proximity of a patient, including detectors and sensors from Sick Incorporated, Minneapolis, Minn., for example. An optional camera could also be used, supported by image processing software that detects the image of a person. The presence of the patient may be used, for example, as part of an energy-saving system, to initiate full power-up from a “power-save” state offundus imaging apparatus 220 in readiness for performing the setup and imaging operations described with reference toFIG. 7 . - Unlike conventional fundus imaging devices currently in use, the apparatus of the present invention is advantaged in its capability to obtain retinal images in an automated fashion, requiring no interaction or intervention by an operator. This also makes
fundus imaging appliance 220 suitable for self-use by a patient.Fundus imaging appliance 220 can be installed in a PCP office or lab facility, or could even be installed in a kiosk enclosure or other environment outside of a conventional medical setting. Where instructions might be helpful or necessary,fundus imaging apparatus 220 may display instructions to the patient or may provide audible instructions using optional speakers, for example. - The present invention provides a fundus imaging apparatus that requires no operator, allows compact packaging, and may not require dilation of the pupil for most patients. It must be emphasized that
fundus imaging appliance 220, as described in the present application, is primarily intended to provide basic fundus imaging that can be inexpensively performed at the office of a PCP or other non-specialist site. Thus, more advanced imaging features and functions are omitted from this description offundus imaging appliance 220. However, the same components and methods for automating setup and focus functions could also be applied to a more sophisticated imaging device. - The invention has been described in detail with particular reference to certain preferred embodiments thereof, but it will be understood that variations and modifications can be effected within the scope of the invention as described above, and as noted in the appended claims, by a person of ordinary skill in the art without departing from the scope of the invention. For example, the various light sources used within
fundus imaging appliance 220 allow a number of optional types. Sensors and CCD devices could be any of a number of different types. Referring toFIG. 25 , an alternate embodiment for illumination directs light from alight source 294 through afiber optic ring 292. This type of arrangement could be beneficial for optimizing illumination brightness and direction. - Although the resolution and overall image quality requirements for
cornea camera 170 andsensor 146 are quite different, a single CCD array could be used for bothcornea camera 170 andsensor 146, switched between these functions, using techniques well known in the imaging arts. Various types of reference locators could be used for assisting in the initial positioning of the patient. The patient is preferably seated; however, imaging could be obtained from a patient in some other position. - Thus, what is provided is an apparatus and method for automated fundus imaging.
-
- 10 fundus imaging apparatus
- 12 illumination section
- 14 observation light source
- 16 lens
- 18 image capture light source
- 20 lens
- 22 half-mirror
- 24 ring-slit diaphragm
- 26 lens
- 28 apertured mirror
- 30 inner ring
- 32 middle section
- 34 outer section
- 36 pupil
- 40 ring
- 46 sensor
- 100 fundus imaging system
- 102 image capture section
- 104 control logic processor
- 112 illumination section
- 114 image capture light source
- 126 lens
- 138 display
- 142 lens
- 144 lens
- 146 sensor
- 147 sensor field
- 160 alignment section
- 162 aiming target light source
- 164 lens assembly
- 166 beamsplitter
- 168 lens
- 170 cornea camera
- 171 field
- 172 beamsplitter
- 174 mirror
- 176 light source
- 178 lens
- 180 cornea focusing section
- 192 retina focusing section
- 195 spatial light modulator
- 210 control workstation
- 212 keyboard
- 214 control logic processor
- 216 network
- 220 fundus imaging appliance
- 222 eye holder
- 224 beamsplitter
- 226 movable polarization beamsplitter
- 227 movable mirror
- 228 target aperture
- 229 LED
- 230 light source
- 231 light source
- 223 aperture
- 233 aperture
- 234 lens
- 236 aperture
- 236 a′ image of aperture
- 236 b′ image of aperture
- 240 light source
- 242 light source
- 246 aperture
- 246 a′ image of aperture
- 246 b′ image of aperture
- 248 aperture
- 250 image
- 251 lens
- 252 image
- 254 image
- 260 display
- 261 cursor
- 262 thumbnail image
- 292 fiber optic ring
- 294 light source
- 300 automated imaging sequence
- 310 patient positioning step
- 320 alignment step
- 330 focus cornea step
- 336 adjust settings step
- 340 focus step
- 350 image capture step
- 400 operator
- 402 patient
- 406 motor
- 408 motor assembly
- 410 indicator element
- 412 aperture
- 414 aperture
- 416 switch
- 420 beamsplitter
- 422 sensor
- 430 folding element
- 432 sensor device
- 434 sensor device
- 435 spatial light modulator
- 436 polarizer
- 438 analyzer
- 440 sensor
- 442 beamsplitter
- 444 prism pair
- 446 sensor field
- 448 optical fiber
- 450 cornea focus detection section
- 452 retina focus detection section
Claims (28)
1. An apparatus for obtaining a retinal image from an eye, comprising:
a) a control logic processor for executing a sequence of operations for obtaining the image;
b) a visual target for orienting the eye of a patient when the target is viewed by the patient;
c) an indicator element for providing a signal that indicates that the patient is in position for imaging;
d) a cornea focus detection section for providing an indication of cornea focus, in cooperation with the control logic processor;
e) an alignment actuator for aligning an optical path of the apparatus according to a signal obtained from the cornea focus detection section;
f) a retina focus detection section for detecting retina focus in cooperation with the control logic processor;
g) a focusing actuator controlled by instructions from the control logic processor according to a signal obtained from the retina focus detection section; and
h) an image capture light source energized by the control logic processor for illuminating the retina for image capture,
wherein the cornea focus detection section comprises:
an aperture element alternately illuminated from first and second light sources, wherein the first and second light sources are switched alternately on and off;
a lens assembly for imaging the aperture element onto the cornea;
a cornea sensor for sensing the aperture element image on the cornea and providing sensed cornea image data to the control logic processor; and
an actuator for adjusting the focus position of components in an imaging path, the actuator controlled according to instructions from the control logic processor, based on the sensed cornea image data.
2. An apparatus according to claim 1 wherein the first and second light sources are LEDs.
3. An apparatus according to claim 1 wherein the cornea sensor comprises a charge-coupled device sensor.
4. An apparatus according to claim 1 wherein the cornea sensor comprises a CMOS sensor.
5. An apparatus according to claim 1 wherein the retina focus detection section comprises:
a) an aperture alternately illuminated from first and second light sources;
b) a lens assembly for imaging the aperture onto the retina;
c) a retina sensor for sensing an image of the retina and providing sensed retina image data to the control logic processor; and
d) a focus actuator for adjusting the focus position of components in an imaging path, the focus actuator controlled according to instructions from the control logic processor, based on the sensed retina image data.
6. An apparatus according to claim 5 wherein the first and second light sources are LEDs.
7. The retina focusing section of claim 5 wherein the first and second light sources are formed by a prism pair.
8. The retina focusing section of claim 5 wherein at least one of the first and second light sources is directed through an optical fiber.
9. A cornea focusing section in an apparatus for obtaining an image of the eye, comprising:
a) a control logic processor for executing an automated sequence of operations for obtaining the image;
b) a cornea focus detection section comprising:
i) an aperture illuminated from first and second light sources, wherein the first and second light sources are switched alternately on and off;
ii) a lens assembly for imaging the aperture onto the cornea;
iii) a cornea sensor for sensing an image of the cornea and providing sensed cornea image data to the control logic processor; and
c) an actuator for adjusting the focus position of components in an imaging path, the actuator controlled according to instructions from the control logic processor, based on the sensed cornea image data.
10. The cornea focusing section of claim 9 wherein the first and second light sources are LEDs.
11. The cornea focusing section of claim 9 wherein the cornea sensor comprises a charge-coupled device.
12. The cornea focusing section of claim 9 wherein the cornea sensor comprises a CMOS device.
13. The cornea focusing section of claim 9 wherein the cornea sensor comprises two or more sensing devices.
14. The cornea focusing section of claim 9 wherein the cornea focus detection section further comprises a folding element.
15. A retina focusing section in an apparatus for obtaining an image of the eye, comprising:
a) a control logic processor for executing an automated sequence of operations for obtaining the image;
b) a retina focus detection section comprising:
i) an aperture illuminated from first and second light sources wherein the first and second light sources are switched alternately on and off;
ii) a lens assembly for imaging the aperture onto the retina;
iii) a retina sensor for sensing an image of the retina and providing sensed retina image data to the control logic processor; and
c) a focus actuator for adjusting the focus position of components in an imaging path, the focus actuator controlled according to instructions from the control logic processor, based on the sensed retina image data.
16. The retina focusing section of claim 15 wherein the first and second light sources are LEDs.
17. The retina focusing section of claim 15 wherein the retina sensor comprises a charge-coupled device.
18. The retina focusing section of claim 15 wherein the retina sensor comprises a CMOS device.
19. The retina focusing section of claim 15 wherein the retina focus detection section further comprises a folding element.
20. A method for obtaining a retinal image comprising:
a) displaying a visual target for orienting the eye of the patient;
b) accepting a signal from an indicator element that is actuated by the patient to confirm visibility of the visual target;
c) detecting cornea focus by alternately illuminating a cornea detection aperture from a first and a second light source, imaging the cornea detection aperture onto the cornea, and sensing the imaged cornea detection aperture;
d) aligning optical components according to the detected cornea focus;
e) detecting retina focus by alternately illuminating a retina detection aperture from a third and a fourth light source, imaging the retina detection aperture onto the cornea, and sensing the imaged retina detection aperture;
f) adjusting a focusing actuator according to the retina focus;
g) illuminating the retina for image capture; and
h) energizing an image capture light source and obtaining an image.
21. The method of claim 20 wherein the step of accepting a signal from an indicator element comprises the step of obtaining the input signal from a sensor that automatically detects the proximity of the patient.
22. The method of claim 20 wherein the step of accepting a signal from an indicator element comprises the step of obtaining the input signal from a switch that is operated by the patient.
23. The method of claim 20 wherein the step of accepting a signal from an indicator element comprises the step of obtaining the input signal from a touchscreen entry by the patient.
24. A method for focusing on the cornea of an eye comprising:
a) illuminating an aperture from first and second light sources, wherein the first and second light sources are switched alternately on and off;
b) imaging the aperture onto the cornea;
c) sensing an image of the cornea and providing sensed cornea image data to a control logic processor;
d) controlling an actuator to adjust the focus position of components in an imaging path; and
wherein the actuator is controlled automatically, according to instructions from the control logic processor, based on the sensed cornea image data.
25. The method of claim 24 wherein the step of sensing an image of the cornea comprises directing reflected light from the cornea to a CCD sensor.
26. The method of claim 24 wherein the step of sensing an image of the cornea comprises directing reflected light from the cornea to a CMOS sensor.
27. A method for focusing on the retina of an eye comprising:
a) illuminating an aperture from first and second light sources;
b) imaging the aperture onto the retina;
c) sensing an image of the retina and providing sensed retina image data to a control logic processor;
d) controlling an actuator to adjust the focus position of components in an imaging path; and
wherein the actuator is controlled automatically, according to instructions from the control logic processor, based on the sensed retina image data.
28. The method of claim 27 wherein the step of illuminating an aperture comprises the step of alternately illuminating the first and second light sources.
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