US20070095855A1 - Blow fill sealed container with twist off top operated by overcap and method of making the same - Google Patents

Blow fill sealed container with twist off top operated by overcap and method of making the same Download PDF

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Publication number
US20070095855A1
US20070095855A1 US11/639,823 US63982306A US2007095855A1 US 20070095855 A1 US20070095855 A1 US 20070095855A1 US 63982306 A US63982306 A US 63982306A US 2007095855 A1 US2007095855 A1 US 2007095855A1
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US
United States
Prior art keywords
frangible seal
container body
overcap
upper cap
closure top
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/639,823
Inventor
James Vogel
Jeffery Setesak
Gregory Pieper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hospira Inc
Original Assignee
Hospira Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/655,718 priority Critical patent/US7188750B2/en
Application filed by Hospira Inc filed Critical Hospira Inc
Priority to US11/639,823 priority patent/US20070095855A1/en
Publication of US20070095855A1 publication Critical patent/US20070095855A1/en
Application status is Abandoned legal-status Critical

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/18Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
    • B65D51/20Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
    • B65D51/22Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
    • B65D51/228Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being removed from the container after the opening
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/1412Containers with closing means, e.g. caps
    • A61J1/1431Permanent type, e.g. welded or glued
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/1475Inlet or outlet ports
    • A61J1/1481Inlet or outlet ports with connection retaining means, e.g. thread or snap-fit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/18Arrangements for indicating condition of container contents, e.g. sterile condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/1468Containers characterised by specific material properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/1475Inlet or outlet ports
    • A61J1/1487Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096Combination of a vial and a syringe for transferring or mixing their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00Methods of manufacture, assembly or production
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2791/00Shaping characteristics in general
    • B29C2791/001Shaping in several steps
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00Details relating to container closures
    • B65D2251/0003Two or more closures
    • B65D2251/0006Upper closure
    • B65D2251/0015Upper closure of the 41-type
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00Details relating to container closures
    • B65D2251/0003Two or more closures
    • B65D2251/0068Lower closure
    • B65D2251/0071Lower closure of the 17-type

Abstract

A container assembly includes a container body having a port or aperture adapted for use with a luer end of a needleless syringe. The aperture is sealed to a closure top by a first frangible seal. An overcap has a cap base sealed to the container body and an upper cap connected to the cap base by a second frangible seal, providing a sterile barrier surrounding the first frangible seal. The second frangible seal is broken by depressing the upper cap toward the container body. Alternatively, the second frangible seal is a removable tear strip broken by tugging on the tear strip. The upper cap includes a detent portion frictionally securing the upper cap to the closure top when the upper cap is depressed toward the container body. The upper cap and secured closure top are removed from container body by twisting the upper cap to break the first frangible seal and open the port.

Description

  • The present invention relates to the field of containers. More particularly this invention relates to a sterile container assembly for storing fluids, including but not limited to drugs, and transferring them to a needleless syringe.
  • BACKGROUND OF THE INVENTION
  • In the past, the general practice of surgeons or other medical practitioners using hypodermic syringes has been to transfer an injection solution to a syringe from ampoules or vials holding a single dose. These ampoules have been adapted to be sealed by a non-resealable cap. The ampoule is opened by rocking the non-resealable cap, tearing the non-resealable cap from an outlet of the ampoule at an area of weakness.
  • The outlets of these ampoules are often designed to mate with the open end of a needleless syringe. The open ends of needleless syringes come in several different forms or shapes. The two most popular forms of needle fitting are the friction fit fitting (such as the luer slip fitting) and the combination of screw thread and friction engagement fitting (such as the luer lock fitting). Ampoules with outlets that are designed to mate with luer slip fittings and ampoules with outlets that are designed to mate with luer lock fittings are known.
  • It will be appreciated that this past practice has required separate sterilizing measures, as solution transfer for injecting into humans requires scrupulous sterilizing of components.
  • Prior solutions for keeping these ampoules sterile include utilization of blister packaging of the ampoules prior to sterilization. This blister packaging is both costly and difficult to remove.
  • Other types of conventional containers have a cover that the user turns to engage the cap and tear the cap from the container. None of these containers are adapted to operate with a needleless syringe. Further, none of these containers are particularly well adapted to prevent compromise or contamination of the sterile port of the container during the manual manipulation required to open the port.
  • Therefore, a principal object of this invention is to provide a container assembly that maintains a sterile attachment zone for a needleless syringe.
  • Another object of the invention is to provide a container assembly that has a guarded sterile syringe attachment zone, which is easily compromised during the manual manipulation, required to open the container assembly.
  • Another object reduces risk of contamination of its opened port by finger touches.
  • Another object of the invention is to provide a container assembly adapted for use with a needleless syringe and which includes an overcap to facilitate removal of a closure top from the container.
  • A further object of the invention is to provide an overcap with an improved detent portion for engaging the closure top of a container.
  • These and other objects will be apparent to those skilled in the art.
  • SUMMARY OF THE INVENTION
  • A container assembly includes a container body having a port adapted for use with a luer end of a needleless syringe. A first frangible seal seals the aperture to a closure top. An overcap has a cap base sealed to the container body and an upper cap connected to the cap base by a second frangible seal, providing a sterile barrier surrounding the first frangible seal. Depressing the upper cap toward the container body breaks the second frangible seal. Alternatively, the second frangible seal is a removable tear strip broken by tugging on the tear strip. The upper cap includes a detent portion frictionally securing the upper cap to the closure top when the upper cap is depressed toward the container body. The upper cap and secured closure top are removed from container body by twisting the upper cap to break the first frangible seal. After removal, the top remains frictionally retained in the upper cap by the detent portion.
  • DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a perspective view of the device of this invention;
  • FIG. 2 is a partial sectional side view of the device of this invention taken on line 2-2 of FIG. 1;
  • FIG. 3 is a partial sectional side view similar to FIG. 2, but the tear strip has been removed;
  • FIG. 4 is a partial sectional side view similar to FIG. 3, but the upper cap has been pressed downward to retentively engage the closure top;
  • FIG. 5 is a partial sectional side view similar to FIG. 4, but the overcap and the closure top retained therein have been removed;
  • FIG. 6 is a partial sectional front view of a syringe and the opened container of this invention;
  • FIG. 7 is a side view of a second embodiment of the device of this invention;
  • FIG. 8 is a partial sectional side view of the device of this invention taken on line 8-8 of FIG. 7;
  • FIG. 9 is a partial sectional side view similar to FIG. 8, but the second frangible seal has been broken and the upper cap has been engaged with the closure top;
  • FIG. 10 is a partial sectional side view of the device of this invention taken on line 10-10 of FIG. 9;
  • FIG. 11 is a partial sectional side view similar to FIG. 10, but the overcap and closure top have been rotated to fracture the first frangible seal; and
  • FIG. 12 is a partial sectional side view similar to FIG. 11, but the overcap and the closure top retained therein have been removed.
  • DESCRIPTION OF THE PREFERRED EMBODIMENT
  • With reference to FIG. 1, a container assembly 10 includes a container body 12 for containing fluid, including but not limited to drugs. An overcap 14 is sealed to the container body 12 to provide a barrier over a portion of the container body 12 to prevent contamination by touch or otherwise. The overcap 14 provides a sterile barrier once the entire container assembly 10 has been sterilized.
  • Referring to FIG. 2, a port 16 provides access to the contents of the container body 12 through an aperture 18. A non-resealable closure top 20 is sealed over the aperture 18 to the container body 12 at a first frangible seal 22. The first frangible seal 22 is a sterilized surface, where the overcap 14 is positioned over the first frangible seal 22 and sealed to the container body 12 to provide a sterile barrier or zone surrounding the first frangible seal 22.
  • A cap base 24 of overcap 14 is sealed to a horizontally extending flange 26 on the container body 12. The cap base 24 has a horizontally extending lip 28 with an outer end 30 and an inner end 32. An annular skirt 34 extends downwardly from the outer end 30 and mates with an outer edge 36 of flange 26 on the container body 12. An annular rim 38 extends upwardly from the inner end 32 of lip 28.
  • Referring to FIGS. 2 and 3, an upper cap 40 of overcap 14 is sealed to the cap base 24 by a second frangible seal 42. A cylindrical skirt portion 44 of upper cap 40 extends downwardly from an outer portion 46 of a radial extending end 48. The second frangible seal 42 seals the cylindrical skirt 44 to the cap base 24.
  • A removable tear strip 50 is located between the annular rim 38 of cap base 24 and the cylindrical skirt portion 44 of upper cap 40, forming the second frangible seal 42. The tear strip 50 has a hold area 52 that extends horizontally from the overcap 14. The hold area 52 permits a user to grasp and pull the hold area 52 to remove the tear strip 50. When tear strip 50 is removed the second frangible seal 42 is broken and the cap base 24 and upper cap 40 are severed from each other.
  • Referring to FIGS. 3 and 4, a detent portion 54 of upper cap 40 frictionally attaches the closure top 20 to the upper cap 40 once the second frangible seal 42 (not shown) is broken. Once the second frangible seal 42 (not shown) is broken by removing the tear strip 50 (not shown), the upper cap 40 is depressed towards the container body 12, mating the detent portion 54 to the closure top 20.
  • The detent portion 54 includes planar finger elements 56 extending downwardly from the end 48 of upper cap 40 and around the closure top 20. Each finger element 56 includes a finger shoulder 58 mateable with a corresponding tang shoulder 60 on the closure top 20.
  • Some force is required to move a bottom edge 62 of the finger shoulder 58 over a leading edge 64 of the tang shoulder 60. Once the upper cap 40 is depressed, a top edge 66 of the finger shoulder 58 contacts a trailing edge 68 of the tang shoulder 60, preventing the closure top 20 from detaching from the detent portion 54. Although various mating configurations are possible, preferably the finger shoulder 58 and the tang shoulder 60 both extend horizontally.
  • Referring to FIG. 5, a grip area 70 is located the outer surface of upper cap 40. The grip area 70 permits a user to grasp and rotate the upper cap 40. As the upper cap 40 is rotated, the mated detent portion 54 and closure top 20 twist relative to the container body 12. This rotation breaks the first frangible seal 22 (not shown). Once the first frangible seal 22 (not shown) is broken, the detent portion 54 and closure top 20 remain mated, and are removed from the container body 12. The closure top 20 is retained within the upper cap 40 once removed from the container body 12.
  • The upper cap 40 provides a balanced application of torque resulting in a clean break of the first frangible seal 22 (not shown). This clean break minimizes the amount of plastic strands generated from the broken seal.
  • Referring to FIG. 6, a luer end 72 of a syringe 74 is inserted into the aperture 18 of port 16 once the closure top 20 is removed. The syringe 74 allows a user to extract fluid content from the container 12. The luer end 72 is shown as a luer lock fitting but may be a luer slip fitting. The luer end 72 includes a male luer 76 and a female threaded surface 78. The male luer 76 is inserted into the aperture 18 of the port 16. The female threaded surface 78 is engaged to port threads 80 located on the port 16 to threadingly mate the luer end 72 to the port 16.
  • Referring to FIGS. 7 through 12, a second embodiment of the present invention includes an upper cap 82 sealed to the cap base 24 by a second frangible seal 84. A cylindrical skirt portion 86 extends downwardly from a rectangular detent portion 88 of upper cap 82. The cylindrical skirt 86 is located within the cap base 24 and is sealed to the cap base 24 by the second frangible seal 84. The second frangible seal 84 can be broken by manually depressing the upper cap 82 toward the container body 12, whereupon the detent portion 88 of upper cap 82 frictionally attaches to a closure top 90. Alternatively, the user can rock the upper cap 82 back and forth until the second frangible seal 84 fractures, then push the upper cap 82 downward.
  • The detent portion 88 includes substantially planar surface elements 92 extending upwardly from cylindrical skirt portion 86 of upper cap 82 and positioned around the closure top 90. Each substantially planar surface element 92 corresponds to a corresponding substantially planar surface portion 94 of closure top 90. One or more optional friction enhancing elements 95 are formed in one or more of the substantially planar surface elements or portions 92, 94. The friction enhancing elements 95 are shown as a pair of raised domes on the substantially planar surface portions 94; however, those skilled in the art will understand from the description herein that other friction enhancing elements or combinations of elements can be utilized, including but not limited to ribs, ribs and grooves, and other complementary or noncomplementary surface irregularities, without detracting from the present invention. At any rate, the substantially planar surface elements 92 and the substantially planar portions 94 are configured so that some force is required to retentively engage planar surface elements 92 to the planar surface portions 94. Once the upper cap 82 is depressed, the planar surface elements 92 frictionally engage the planar surface portions 94, preventing the closure top 90 from detaching from the detent portion 88.
  • Referring to FIGS. 7, 10 and 12, a grip area 96 is located on the outer surface of upper cap 82 and at least forms a portion of the outer surface of detent portion 88. The grip area 96 permits a user to grasp and rock or rotate the upper cap 82. As the upper cap 82 is rotated, the mated detent portion 88 and closure top 90 twist relative to the container body 12. This rotation breaks the first frangible seal 22. Once the first frangible seal 22 is broken, the detent portion 88 and closure top 90 remain mated, and are removed from the container body 12. The closure top 90 is retained within the upper cap 82 once removed from the container body 12.
  • Referring to FIGS. 2 and 8, during formation, the container body 12 and closure top 20 or 90 are formed by a blow/fill/seal method and then sterilized. The material that forms the container body 12, the closure top 20 or 90, and the overcap 14 can be any material suitable for blow fill molding, and autoclave sterilization including but not limited to glass and plastic. More preferably, the material is polypropylene based or polyethylene tetrachloride-based. Most preferably, the material is a polypropylene random copolymer, such as Huntsman 23M2CS30A or Exxon Mobil 9122. The overcap 14 is fusion welded to the container 12. The container body 12 and overcap 14 assembly are then autoclaved to sterilize the entire container assembly 10. The overcap 14 is not fixed to the closure top 20 or 90 during autoclaving, permitting expansion at different rates and in different dimensions so as to prevent unnecessary strain on the container assembly 10. Once the entire container assembly 10 is sterilized, the overcap 14 preserves the sterility of first frangible seal 22. When the second frangible seal 42 or 84 is broken, a sterile uncontaminated port 16 remains until the closure top 20 or 90 is rotated by the overcap 14 and removed from the container 12.
  • It is therefore seen that the present invention provides a container assembly that maintains a sterile barrier or zone around the port until just prior to use. The present invention further provides a container assembly adapted for use with a syringe and which includes an overcap to facilitate removal of a closure top from the container with a twisting motion rather than the usual rocking motion that can lead to spillage and contamination by touch. The present invention also provides an overcap with an improved detent portion for engaging the closure top of a container.
  • It is therefore seen that this invention will accomplish at least all of its stated objectives.

Claims (9)

1. A container assembly, comprising:
a container body adapted to contain fluid, including a port having an aperture therein;
a closure top attached over the aperture of the container body with a first frangible seal; and
an overcap positioned over the first frangible seal and hermetically sealed to the container body to provide a sterile barrier surrounding the first frangible seal.
2. The container assembly of claim 1, wherein the port is adapted for use with a luer end of a needleless syringe.
3. The container assembly of claim 2, wherein the luer end is a luer lock fitting.
4.-11. (canceled)
12. A container assembly for use with a needleless syringe having a luer end, comprising:
a container body adapted to contain fluid, including a port having an aperture therein adapted for use with a luer end of a syringe;
a closure top attached over the aperture of the container body with a first frangible seal; and
an overcap including a detent portion for associating the overcap to the closure top to allow a user to break the first frangible seal and remove the closure top by twisting the overcap;
wherein the overcap is positioned over the first frangible seal and hermetically sealed to the container body to provide a sterile barrier surrounding the first frangible seal.
13. The container assembly of claim 12, wherein the luer end is a luer lock fitting.
14.-18. (canceled)
19. The container assembly of claim 12, wherein the detent portion frictionally attaches the closure top to the overcap.
20.-30. (canceled)
US11/639,823 2003-09-05 2006-12-15 Blow fill sealed container with twist off top operated by overcap and method of making the same Abandoned US20070095855A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/655,718 US7188750B2 (en) 2003-09-05 2003-09-05 Blow fill sealed container with twist off top operated by overcap and method of forming the same
US11/639,823 US20070095855A1 (en) 2003-09-05 2006-12-15 Blow fill sealed container with twist off top operated by overcap and method of making the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/639,823 US20070095855A1 (en) 2003-09-05 2006-12-15 Blow fill sealed container with twist off top operated by overcap and method of making the same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/655,718 Continuation US7188750B2 (en) 2003-09-05 2003-09-05 Blow fill sealed container with twist off top operated by overcap and method of forming the same

Publications (1)

Publication Number Publication Date
US20070095855A1 true US20070095855A1 (en) 2007-05-03

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Application Number Title Priority Date Filing Date
US10/655,718 Expired - Fee Related US7188750B2 (en) 2003-09-05 2003-09-05 Blow fill sealed container with twist off top operated by overcap and method of forming the same
US11/639,823 Abandoned US20070095855A1 (en) 2003-09-05 2006-12-15 Blow fill sealed container with twist off top operated by overcap and method of making the same
US11/643,136 Abandoned US20070102850A1 (en) 2003-09-05 2006-12-20 Blow fill sealed container with twist off top operated by overcap and method of making the same
US11/643,135 Abandoned US20070095856A1 (en) 2003-09-05 2006-12-21 Blow fill sealed container with twist off top operated by overcap and method of making the same
US11/643,133 Abandoned US20070102446A1 (en) 2003-09-05 2006-12-21 Blow fill sealed container with twist off top operated by overcap and method of making the same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10/655,718 Expired - Fee Related US7188750B2 (en) 2003-09-05 2003-09-05 Blow fill sealed container with twist off top operated by overcap and method of forming the same

Family Applications After (3)

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US11/643,136 Abandoned US20070102850A1 (en) 2003-09-05 2006-12-20 Blow fill sealed container with twist off top operated by overcap and method of making the same
US11/643,135 Abandoned US20070095856A1 (en) 2003-09-05 2006-12-21 Blow fill sealed container with twist off top operated by overcap and method of making the same
US11/643,133 Abandoned US20070102446A1 (en) 2003-09-05 2006-12-21 Blow fill sealed container with twist off top operated by overcap and method of making the same

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US (5) US7188750B2 (en)
EP (1) EP1670411A1 (en)
JP (1) JP2007503919A (en)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2301378A1 (en) 2009-09-23 2011-03-30 L'Oréal Dispenser of a cosmetic product on a receiving surface, associated dispenser and method

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7188750B2 (en) * 2003-09-05 2007-03-13 Hospira, Inc. Blow fill sealed container with twist off top operated by overcap and method of forming the same
ITMO20030283A1 (en) * 2003-10-21 2005-04-22 Lameplast Spa Bottle for fluid products, particularly pharmaceutical,
JP4045277B2 (en) * 2005-01-17 2008-02-13 株式会社ファンケル Bottle container
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US9440754B2 (en) * 2012-03-29 2016-09-13 R.P. Scherer Technologies, Llc Three circuit fill system for blow fill seal containers
US9265889B2 (en) 2012-04-25 2016-02-23 Adar Medtech, Inc. Prefilled medical injection device
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US9867973B2 (en) * 2013-06-17 2018-01-16 Medline Industries, Inc. Skin antiseptic applicator and methods of making and using the same
US9669974B2 (en) * 2013-12-17 2017-06-06 Aptar Radolfzell Gmbh Protective cap for a dispenser, and discharge device for discharging pharmaceutical and/or cosmetical liquids
US9676525B2 (en) 2013-12-17 2017-06-13 Aptar Radolfzell Gmbh Protective cap for a dispenser, and discharge device for discharging pharmaceutical and/or cosmetical liquids
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USD776266S1 (en) 2014-10-24 2017-01-10 3M Innovative Properties Company Liquid applicator body
USD777909S1 (en) 2015-07-10 2017-01-31 3M Innovative Properties Company Liquid applicator body
DE102016116098A1 (en) * 2016-08-30 2018-03-01 B. Braun Avitum Ag Cap for a cartridge-shaped container

Citations (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134511A (en) * 1976-11-27 1979-01-16 Stella Kg Werner Deussen Container with frangible seal
US4402415A (en) * 1980-10-17 1983-09-06 U. G. Closures & Plastics Limited Integrally sealed container with cap
US4434904A (en) * 1980-06-09 1984-03-06 Baxter Travenol Laboratories, Inc. Bottle closure
US4463878A (en) * 1981-04-27 1984-08-07 Axel Crone Cap unit
US4494663A (en) * 1984-01-05 1985-01-22 Abbott Laboratories Sterile solution container
US4527700A (en) * 1983-03-07 1985-07-09 Cebal Closure device for a necked container
US4620638A (en) * 1983-10-07 1986-11-04 Milupa Aktiengesellschaft Cap for opening and extracting the contents of a vessel
US4643309A (en) * 1982-02-08 1987-02-17 Astra Lakemedel Ab Filled unit dose container
US4662529A (en) * 1985-02-28 1987-05-05 Schering Chemicals Limited Bottle with frangible neck and cap
US5007546A (en) * 1987-07-14 1991-04-16 Waverley Pharmaceuticals Limited Bottle caps
US5158192A (en) * 1989-10-26 1992-10-27 Laboratoires Merck Sharp & Dohme-Chibret Dispensing bottle with coupling between closure head and screw cap
US5228593A (en) * 1991-10-24 1993-07-20 Cp Packaging, Inc. Container-closure assembly
US5409125A (en) * 1989-12-11 1995-04-25 Aktiebolaget Astra Unit dose container
US5419459A (en) * 1992-01-31 1995-05-30 Cp Packaging, Inc. Child resistant medicament dispenser
US5425920A (en) * 1994-02-23 1995-06-20 Carlo Erba Reagenti S.R.L. Vial for chemical reagents
US5653686A (en) * 1995-01-13 1997-08-05 Coulter Corporation Closed vial transfer method and system
US5813570A (en) * 1994-04-08 1998-09-29 Ing. Erich Pfeiffer Gmbh Apparatus for controllably discharging flowable media
US6000578A (en) * 1995-02-01 1999-12-14 Carnaudmetalbox Sante-Beaute Bottle body and product dispensing bottle
US6126045A (en) * 1997-07-21 2000-10-03 Itsac N.V. Connector assembly for a fluid connection
US6321942B1 (en) * 1997-01-09 2001-11-27 Ing. Erich Pfeiffer Gmbh Discharge device for flowable media using a thrust piston pump
US20020035820A1 (en) * 1998-10-01 2002-03-28 Barry Farris Needleless method and apparatus for transferring liquid from a container to an injecting device without ambient air contamination
US20020126120A1 (en) * 2000-12-22 2002-09-12 Xerox Corporation Electronic board system
US20030032923A1 (en) * 2001-01-12 2003-02-13 Eakins Michael N. Tamper evident syringe barrel
US7188750B2 (en) * 2003-09-05 2007-03-13 Hospira, Inc. Blow fill sealed container with twist off top operated by overcap and method of forming the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US528593A (en) * 1894-11-06 Bail wat signaling system
US3851029A (en) * 1973-03-07 1974-11-26 Respiratory Care Method for molding and sealing thermoplastic containers
US4320638A (en) * 1979-05-10 1982-03-23 Ogden Industries Pty. Limited Tumbler lock and key
US5918783A (en) * 1997-06-26 1999-07-06 Courtaulds Packaging, Inc. Thermoplastic squeeze tube with self-sealing dispensing orifice
EP1115362B1 (en) * 1998-09-22 2002-12-04 Fresenius Kabi AB Container for intravenous administration
DE10025097B4 (en) * 2000-05-20 2004-04-15 Robert Bosch Gmbh the same optical sensor and methods for preparing
US6502369B1 (en) * 2000-10-25 2003-01-07 Amcor Twinpak-North America Inc. Method of supporting plastic containers during product filling and packaging when exposed to elevated temperatures and internal pressure variations

Patent Citations (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134511A (en) * 1976-11-27 1979-01-16 Stella Kg Werner Deussen Container with frangible seal
US4434904A (en) * 1980-06-09 1984-03-06 Baxter Travenol Laboratories, Inc. Bottle closure
US4402415A (en) * 1980-10-17 1983-09-06 U. G. Closures & Plastics Limited Integrally sealed container with cap
US4463878A (en) * 1981-04-27 1984-08-07 Axel Crone Cap unit
US4643309A (en) * 1982-02-08 1987-02-17 Astra Lakemedel Ab Filled unit dose container
US4527700A (en) * 1983-03-07 1985-07-09 Cebal Closure device for a necked container
US4620638A (en) * 1983-10-07 1986-11-04 Milupa Aktiengesellschaft Cap for opening and extracting the contents of a vessel
US4494663A (en) * 1984-01-05 1985-01-22 Abbott Laboratories Sterile solution container
US4662529A (en) * 1985-02-28 1987-05-05 Schering Chemicals Limited Bottle with frangible neck and cap
US5007546A (en) * 1987-07-14 1991-04-16 Waverley Pharmaceuticals Limited Bottle caps
US5090581A (en) * 1987-07-14 1992-02-25 Waverley Pharmaceuticals, Ltd. Bottle caps
US5158192A (en) * 1989-10-26 1992-10-27 Laboratoires Merck Sharp & Dohme-Chibret Dispensing bottle with coupling between closure head and screw cap
US5409125A (en) * 1989-12-11 1995-04-25 Aktiebolaget Astra Unit dose container
US5228593A (en) * 1991-10-24 1993-07-20 Cp Packaging, Inc. Container-closure assembly
US5419459A (en) * 1992-01-31 1995-05-30 Cp Packaging, Inc. Child resistant medicament dispenser
US5425920A (en) * 1994-02-23 1995-06-20 Carlo Erba Reagenti S.R.L. Vial for chemical reagents
US5813570A (en) * 1994-04-08 1998-09-29 Ing. Erich Pfeiffer Gmbh Apparatus for controllably discharging flowable media
US5653686A (en) * 1995-01-13 1997-08-05 Coulter Corporation Closed vial transfer method and system
US6000578A (en) * 1995-02-01 1999-12-14 Carnaudmetalbox Sante-Beaute Bottle body and product dispensing bottle
US6321942B1 (en) * 1997-01-09 2001-11-27 Ing. Erich Pfeiffer Gmbh Discharge device for flowable media using a thrust piston pump
US6126045A (en) * 1997-07-21 2000-10-03 Itsac N.V. Connector assembly for a fluid connection
US20020035820A1 (en) * 1998-10-01 2002-03-28 Barry Farris Needleless method and apparatus for transferring liquid from a container to an injecting device without ambient air contamination
US20020126120A1 (en) * 2000-12-22 2002-09-12 Xerox Corporation Electronic board system
US20030032923A1 (en) * 2001-01-12 2003-02-13 Eakins Michael N. Tamper evident syringe barrel
US7188750B2 (en) * 2003-09-05 2007-03-13 Hospira, Inc. Blow fill sealed container with twist off top operated by overcap and method of forming the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2301378A1 (en) 2009-09-23 2011-03-30 L'Oréal Dispenser of a cosmetic product on a receiving surface, associated dispenser and method

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EP1670411A1 (en) 2006-06-21
US20070102446A1 (en) 2007-05-10
WO2005025483A1 (en) 2005-03-24
US7188750B2 (en) 2007-03-13
US20070095856A1 (en) 2007-05-03
AU2004271980A1 (en) 2005-03-24
US20070102850A1 (en) 2007-05-10
US20050051572A1 (en) 2005-03-10
JP2007503919A (en) 2007-03-01
CA2537296A1 (en) 2005-03-24

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