US20070088355A9 - Transseptal left atrial access and septal closure - Google Patents

Transseptal left atrial access and septal closure Download PDF

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Publication number
US20070088355A9
US20070088355A9 US10856475 US85647504A US2007088355A9 US 20070088355 A9 US20070088355 A9 US 20070088355A9 US 10856475 US10856475 US 10856475 US 85647504 A US85647504 A US 85647504A US 2007088355 A9 US2007088355 A9 US 2007088355A9
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Prior art keywords
rf
catheter
penetrating
probe
sealing
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US10856475
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US20050033288A1 (en )
US8052677B2 (en )
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David Auth
Robert Barry
Robert Schwartz
Robert Van Tassel
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CoAptus Medical Corp
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CoAptus Medical Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1492Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00029Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00214Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022Balloons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00214Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022Balloons
    • A61B2018/0025Multiple balloons
    • A61B2018/00261Multiple balloons arranged in a line
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00351Heart
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00619Welding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B2018/1405Electrodes having a specific shape
    • A61B2018/1407Loop

Abstract

Methods, systems, and devices for transseptal access into the left atrium of a heart. In one embodiement an apparatus for transseptal left atrial access comprised of a catheter adapted for insertion into a vessel and one or more RF devices adapted to be extendable from the distal end of said catheter and configured for the penetration or sealing of septal tissue.

Description

    COPYRIGHT NOTICE
  • [0001]
    A portion of this patent document contains material that is subject to copyright protection. The copyright owner does not object to the facsimile reproduction of the patent document as it appears in the U.S. Patent and Trademark Office patent file or records but otherwise reserves all copyright rights whatsoever.
  • FIELD OF THE INVENTION
  • [0002]
    The present invention relates generally to the medical arts and specifically to transseptal methods, devices, and systems for accessing the left atrium of a patient's heart and for sealing closed an opening in the septum and/or for sealing septal tissue together.
  • BACKGROUND OF THE INVENTION
  • [0003]
    With recent advances in the cardiovascular arts, there's a renewed interest in finding safe and uncomplicated methods for accessing the left atrium of a patient's heart. Currently, a retrograde transaortal technique is most often and involves advancing a catheter through the aorta, into the left ventricle, accessing the left atrium from the left ventricle. However, this path into the left atrium is tortuous. A simple and more attractive alternative is accessing the left atrium directly from the right atrium by crossing the interatrial septum (“septum”) that divides the two atrial chambers of the heart. The right atrium can be easily accessed and crossing the septum is the only requirement to entering the left atrium.
  • [0004]
    The left atrium can be accessed by puncturing across the septum of the heart at the fossa ovalis membrane, typically the thinnest part of the septum, with a needle-like device such as a Brockenbough needle. While this technique has been widely known since the 1950's, it has not been used largely because the technique has not proven reliable or secure. Misalignment or the incorrect orientation of the needle against the septum, for example, may have severe consequences for the patient, including perforation of the left atrium of the heart or perforation of a patient's aorta. Inadvertent perforations of the inferior vena cava and the coronary sinus have also been reported as a possible complication of this technique. Therefore, rapid, precise and controlled methods and devices for crossing the interatrial septum are needed. The present invention meets these, as well as other, needs.
  • SUMMARY OF THE INVENTION
  • [0005]
    Broadly, the invention is directed at methods and radiofrequency (RF) devices for crossing an interatrial septum and sealing an opening in it closed.
  • [0006]
    In yet another aspect of the invention, methods, RF systems and devices for sealing septal tissue are provided.
  • [0007]
    In yet another aspect of the invention, methods, RF systems, and devices for sealing closed an naturally occurring opening in a heart is a provided.
  • [0008]
    These, as well as other additional embodiments and features of the invention, will appear in the following description in conjunction with the accompanying drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0009]
    FIGS. 1A-1C are schematics illustrating the types of opening and closure patterns that can be created in the interatrial septum in accordance with the present invention.
  • [0010]
    FIGS. 2-4 illustrate various embodiments of RF penetrating probes in accordance with the present invention.
  • [0011]
    FIGS. 5-6 illustrate various embodiments of RF sealing probes in accordance with the present invention.
  • DESCRIPTION OF THE EMBODIMENTS
  • [0012]
    Broadly, methods, systems and RF devices for crossing the septum 1 and creating openings 3 of a specified size and pattern are provided. Methods, systems and RF devices for closing these openings 3 and joining septal tissue are also provided. Openings 3 in a wide variety of patterns and sizes can be created in the septum 1 in accordance with the present invention, including but not limited to: single slits 5 (FIG. 1A), radial slits 7 (FIG. 1B) and a plurality of bisecting slits 9 (FIG. 1C) as illustrated in FIGS. 1A-1C. The specific shape or pattern of the opening 3 is determined by the configuration of the wire(s) or electrodes(s) located on the distal end of an RF penetrating device or catheter as described herein. FIG. 1 further illustrates yet another aspect of the invention involving the use of an adaptively shaped RF sealing device or catheter to close the various types of openings 3. The dotted lines in FIG. 1 depict the shapes of various RF sealing devices or catheters that can be preferentially used to close septal openings 3 and join septal tissues 1 flaps together.
  • [0013]
    Turing now to the other figures, FIGS. 2, 3 and 4 illustrates various embodiments of RF penetrating devices 11. The various RF penetrating devices 11 are comprised of an RF penetrating probe 13 located at a distal end 15. The RF penetrating probe 13 is comprised of one or more wires 17 arranged in a particular shape. In a preferred embodiment, the RF penetrating probes 13 are made of shape memory wires 17 (such as Nitinol) to ensure the correct formation of the desired shape when the RF penetrating probe 13 is exposed inside the right atrium. The correct shape and orientation of the RF penetrating probe 13 and wires 17 against the septum 1 will determine the pattern of the opening 3 created in the septum 1 by the RF penetrating probe 13. When energized, the wires 17 or electrodes will supply sufficient RF energy to affect tissue penetration upon contact in the pattern dictated by the arrangement of the RF probe 13.
  • [0014]
    Each wire 17 of an RF penetrating probe 13 can be configured as a wire electrode, or in yet another implementation, each wire may be comprised of one or more spaced RF electrodes located within insulated shape memory wires. The electrodes of an RF penetrating probe 11 can be configured to operate as monopolar or bipolar electrodes delivering sufficient RF current to electrosurgically penetrate septal tissue 1 on contact. As will be readily appreciated by one skilled in the art, various strategies can be implemented to prevent sticking of tissues to the RF penetrating probes 13, wires 17 or electrodes described herein. In one possible implementation, various fluids or gels (either cooling and/or electrically conductive) may be used to prevent sticking of tissues during the penetration procedure. Yet another possible implementation may include a fluid (cooling or conductive) eluted from one or more ports located on a guide catheter. Alternatively, a fluid, coating or gel can be used on the RF probes 13, wires 17, or electrodes themselves to prevent tissue adhesion to the devices. In addition, one or more feedback sensors may be incorporated the present invention, preferably located adjacent to the RF penetration probes 13 to prevent unintended injury. The one or more feedback sensors can be configured to measure tissue impedances, temperatures, etc. as a means of preventing or controlling tissue heating, overheating or excessive tissue adhesion caused by heat generation.
  • [0015]
    FIG. 2 illustrates one embodiment of an RF penetration probe 13 for creating a slit-like opening 5 in the septum 1 of a patient's heart. As shown, the RF probe 13 comprises a relatively straight RF wire 17. RF wire 17 is attached to a connection member 23, which secures it to the distal end 15 of the RF penetration catheter 11. A described above, RF wire 17 can be configured as a wire electrode or can be comprised of a electrode located preferably in the middle of wires 17 wherein the ends of wire are insulated as illustrated. The size of the RF wire 17 or the electrode will depend on the desired size of the septal opening 3; if a longer slit 5 is desired a larger RF wires 17 or electrode may be employed. Though not illustrated, RF wire 17 is operationally connected by lead wires, or other like means, to an RF generator or energy source (not shown).
  • [0016]
    FIG. 3 illustrates yet another embodiment of an RF penetration probe 13. In this embodiment, RF penetration probe 13 is comprised of a plurality of wires 17 radiating from center point 0. The wires 17 of the RF penetration probe 13, which are preferably straight, are secured to connection member at center point 0. This RF penetration probe 13 illustrated in FIG. may be used to create the type of opening 7 depicted in FIG. 1B.
  • [0017]
    FIG. 4 illustrates yet another embodiment of the present invention wherein RF penetration probe 13 comprise a plurality of bisecting RF wires 17 that can be used to affect an opening 9 of the type illustrated in FIG. 1C. Each wire 17 in these embodiments may be configured as a wire electrode 17 or portions of the wire may be insulated 21.
  • [0018]
    Turing to FIGS. 5 and 6, yet another aspect of the invention, is provided. In this aspect, various RF tissue sealing devices or catheters 31 comprising a distally located RF sealing probe 33, are illustrated. The RF sealing probe 33 is comprised of one or more wires 17 arranged in a pre-determined shape. Similar to the RF penetrating devices 11, the RF tissue sealing devices 31 can be configured as separate catheter device insertable into a guide catheter, or alternatively, can adapted to extend from the distal end of a guide catheter by use of a manipulator. For example, movement of a manipulator may control extension or retraction of both an RF penetrating device 11 and an RF sealing device 31 from the distal end of a guide catheter. To affect closure, RF wires 17, or electrodes of a RF sealing device 31, are configured to be operable at less intense modalities than the electrodes of an RF penetrating device 11 or probe 13. Specifically, the RF sealing probes 33 and the electrodes comprised therein are configured to heat, melt or coagulate tissues coming in contact with it. In addition, as provided in the art, heating of tissues at less intense parameters will trigger a healing response in the RF heated tissues, which will contribute and further promote closure of an opening and promote sealing of septal tissues.
  • [0019]
    Like the RF penetration probes 13, the RF sealing probes 33 of the present invention can be configured in a variety of shapes and sizes depending on the opening 3 to be closed. As illustrated in FIG, RF sealing probe 33 may be a circular wire 35 or a straight wire 37. Circular or straight type wires 35, 37 can be used to seal an opening 3 having several different patterns; for example, a circularly shaped RF sealing probe 35 can be used to seal a radial 7 or slit type 5 opening as illustrated in FIG. 1.
  • [0020]
    The various devices of the invention can be used similarly. The RF devices (including the tissue penetrating 11, 13 and sealing devices, catheters, probes 31, 33) can be delivered as a component of a catheter assembly system. The catheter assembly can comprise: a conventional guide or sheath catheter that can be introduced over a guidewire (not shown), an RF penetrating device 11 and/or an RF sealing device 31. First, the catheter assembly can be introduced into the right atrium from a number of access points using well known catheterization techniques. For example, to gain access to a patient's vasculature and the right atrium of the heart, commercially available introducers can be inserted into a vessel such as into the femoral vein or artery. The introducer can be of a variety of sizes, 4-14 French. The guide catheter should be readily insertable into an introducer and extend from the access point to the septum; this will require use of a guide catheter about 80-120 cm long and about 4-14 French. The guide catheter can be manufactured in accordance with a variety of known techniques, including as an extrusion of an appropriate material, such as high density polyethylenes (HDPE), polytetrafluoroethylenes, nylons, polyether-block amides, polyurethanes, polyimides, polyolefin copolyester and the like. However, other catheter materials well known in the catheter art, as well as various braiding techniques, may be employed depending on the desired catheter performance characteristics. In one embodiment, the guide catheter can be manufactured to be self-positioning to a desired location on a septum 3. For example, the guide catheter can be adapted so its distal tip preferentially locates to pre-determined position (such as at the fossa ovalis or above it), in which case the appropriate braiding technique can be used to affect preferential positioning of the distal tip of the catheter. Other component of the catheter assembly, in addition to a guide catheter, can include one or more of the following: an RF penetrating device 11, an RF sealing device 31, a guidewire, imaging components and the like. These components can be configured to be inserted into and extend out of the distal end of a guide catheter. Alternatively, these components, such as the RF devices 11, 31 can be configured to be extendable from the distal tip of guide catheter via a manipulator or other like means located at a proximal end of the guide catheter. In addition, these devices 11, 31 can be configured to extend only to pre-determined distances from the distal end of a guide catheter to ensure accurate penetration of the interatrial septum 1.
  • [0021]
    An RF penetrating device or catheter 5 can then be advanced into the guide catheter 43 and an RF penetrating probe 13 extended from its distal end. The RF penetration probe 43 should be placed into contact against the septum 1, and the electrodes energized to affect penetration. Pressure exerted on the proximal end of the RF penetration device or catheter 11 can used to ensure contact of septal tissue and the RF penetration probe 13. Other possible implementations include configuring the guide catheter to include a vacuum or suction port to help immobilize septal tissue against the RF penetration probe 13 during septal penetration.
  • [0022]
    Once a desired opening 3 has been created, the RF penetrating device or catheter 11 can be withdrawn from the guide catheter and replaced with other diagnostic or therapeutic devices or catheters. Once the left atrium has been sufficiently accessed and the other devices and catheters withdrawn, the closing or sealing procedure can be initiated using the RF sealing device or catheter 31 of the present invention. To affect closure or sealing of an atrial opening 3, a RF sealing probe 33 should be delivered into the right atrium and the RF wire or electrodes 17 energized. As previously described, activation of the RF sealing probe 33 will cause tissue and collagen melting, as well as coagulation, around the tissue flaps 1 of a septal opening 3. In addition, a heat-induced healing process, including scar formation and cell proliferation, will further contribute to of the septal closure and adhesion of the septal tissues.
  • [0023]
    As will be readily appreciated by one skilled in the art, the RF sealing devices and catheters 31 may be configured and used not only to seal actively created openings 3 but also those that occur naturally (ASDs, PFOs, floppy or aneurismal septums or PFOs). In one method of treatment, the distal end of an RF treatment catheter can be delivered adjacent an aneurismal or floppy PFO and RF energy applied to tighten the loose or septal tissue.
  • [0024]
    While this invention has been described in terms of specific embodiments, other embodiments will become apparent to those skilled in the art. Accordingly, the scope of the present invention is not intended to be limited by the specific embodiments disclosed herein, but rather, by the full scope of the claims.

Claims (29)

  1. 1. A method for crossing an interatrial septum of a patient's heart, said method comprising:
    (a) advancing a catheter having an elongated shaft with a proximal portion, a distal portion, and at least one lumen, into a right atrium of the heart;
    (b) locating a fossa ovalis membrane;
    (c) advancing an RF penetrating probe comprising one or more electrodes adjacent to the fossa ovalis; and
    (d) energizing the one or more electrodes and creating an opening of a desired pattern and size through the fossa ovalis.
  2. 2. The method of claim 1, further comprising the step of: providing an imagining apparatus.
  3. 3. The method of claim 1, wherein a user applied force to a proximal end of the catheter causes contact between the one or more electrodes and the fossa oavlis.
  4. 4. The method of claim 1, further comprising: applying a suction against the atrial septum to cause one or more of the following: immobilization of the interatrial septum or direct contact between the one or more RF electrodes.
  5. 5. The method of claim 1, wherein a grasping member is provided to stabilize of the distal end of the catheter against the fossa ovalis.
  6. 6. The method of claim 5, wherein the grasping member is disposed on the penetrating member.
  7. 7. The method of claim 1, further comprising the step of: eluting a fluid from the distal end of the catheter.
  8. 8. The method of claim 7, wherein the fluid is electrically conductive.
  9. 9. The method of claim 8, wherein the fluid is a cooling fluid.
  10. 10. The method of claim 11, wherein the RF penetrating probe is extendable through a distal port located at the distal end of the catheter.
  11. 11. The method of claim 10, wherein the penetrating probe is extendable to a pre-determined distance beyond the distal end of the guiding catheter.
  12. 12. The method of claim 18, wherein the RF penetrating probe is comprised of at least one wire electrode.
  13. 13. The method of claim 12 wherein the wire electrode is made of a shape memory material.
  14. 14. The method of claim 13, wherein the wire electrode is made of a metal.
  15. 15. A method for penetrating and closing an opening in a atrial septum, said method comprising:
    (a) advancing a catheter having an elongated member with a proximal portion, a distal portion, and one or more lumens, into a right atrium of a patient's heart;
    (b) presenting an RF penetrating probe configured to penetrate tissue and having one or more RF penetrating electrodes disposed thereon;
    (c) energizing the one or more RF penetrating electrodes and creating an opening of a desired pattern and size in the septum;
    (d) presenting an RF sealing probe configured to melt and coagulate tissue and comprising one or more RF sealing electrodes disposed thereon; and
    (e) energizing the one or more RF sealing electrode and joining septal tissues cut in step (c) at one or more locations.
  16. 16. The method of claim 15, further comprising the step of: providing an imagining apparatus.
  17. 17. The method of claim 15, wherein the RF penetrating electrodes are in direct contact with septal tissue at a fossa ovalis.
  18. 18. The method of claim 17, wherein a user applied force at a proximal end of the catheter causes contact between the first RF penetrating electrodes and the RF sealing electrodes and the septum.
  19. 19. The method of claim 15, further comprising: applying a suction against the atrial septum to cause one or more of the following: immobilization of the interatrial septum or direct contact between the one or more RF electrodes and the septum.
  20. 20. The method of claim 19, wherein a grasping member is provided to stabilize of the distal end of the catheter against the septum.
  21. 21. The method of claim 15, further comprising the step of: eluting a fluid from the distal end of the catheter.
  22. 22. The method of claim 21, wherein the fluid is electrically conductive.
  23. 23. The method of claim 22, wherein the fluid is a cooling fluid.
  24. 24. The method of claim 15, wherein the RF penetrating probe and the RF sealing probe are extendable to a predetermined distance beyond the distal end of the catheter.
  25. 25. A method for penetrating an atrial septum from the right atrium of a patient's heart, said method comprising:
    (a) advancing a distal end of a catheter into a superior vena cava until a distal end of a catheter is resting against a wall of the superior vena cava;
    (b) applying a force to a proximal end of the catheter whereby the distal end of the catheter is moved from the superior vena cava against a wall of the right atrium;
    (c) detecting a movement on the proximal end of the catheter signifying placement of the distal end of the catheter adjacent a fossa ovalis membrane;
    (d) presenting an RF penetrating member comprising one or more RF penetrating electrodes adjacent the fossa ovalis; and
    (e) energizing the one or more RF penetrating electrodes thereby creating an opening of a desired pattern and size in the fossa ovalis.
  26. 26. A method for closing a patent foramen ovale (PFO) or other cardiac defects located on an interatrial septum of a patient's heart, said method comprising:
    (a) locating a fossa ovalis membrane;
    (b) crossing the interatrial septum at the fossa ovalis;
    (c) presenting an RF sealing probe comprising one or more RF sealing electrodes; and
    (d) energizing the one or more RF sealing electrodes.
  27. 27. A method for treating an aneurismal interatrial septum, said method comprising:
    (a) locating a treatment position on the septum from a right atrium of the heart;
    (b) presenting a distal end of a RF treatment device comprising one or more RF electrodes one or more electrodes adjacent the treatment location;
    (c) energizing the one or more electrodes; and
    (d) delivering sufficient energy to the treatment location to cause a heat mediated tissue modification whereby the septum is tightened.
  28. 28. A system for penetrating an atrial septum separating right and left atriums of a heart, said system comprising:
    (a) a catheter configured for delivering an RF penetrating probe into the right atrium and adjacent the septum;
    (b) an RF generator operationally coupled to the RF penetrating probe;
    and wherein the RF penetrating probe configured to deliver sufficient RF energy to tissues of the atrial septum to allow penetrating thereof.
  29. 29. A system for penetrating an atrial septum separating right and left atriums of the heart, said system comprising:
    (a) a catheter configured for delivering an RF penetrating probe and an RF sealing probe into the right atrium and adjacent the septum;
    (b) an RF generator operationally coupled to the RF penetrating probe and the RF sealing probe; and
    wherein the RF penetrating probe configured to deliver sufficient RF energy to tissues of the atrial septum creating an opening therethrough; and the RF sealing probe configured to deliver sufficient RF energy to the tissues adjacent to the opening to cause coagulation and sealing of the adjacent tissues thereby sealing the opening.
US10856475 2003-02-13 2004-05-28 Transseptal left atrial access and septal closure Expired - Fee Related US8052677B2 (en)

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US47405503 true 2003-05-28 2003-05-28
US10754790 US8021359B2 (en) 2003-02-13 2004-01-08 Transseptal closure of a patent foramen ovale and other cardiac defects
US10856475 US8052677B2 (en) 2003-02-13 2004-05-28 Transseptal left atrial access and septal closure

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US11695467 US20080009859A1 (en) 2003-02-13 2007-04-02 Transseptal left atrial access and septal closure

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US11650348 Abandoned US20070203479A1 (en) 2003-02-13 2007-01-05 Transseptal closure of a patent foramen ovale and other cardiac defects
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US20040267191A1 (en) * 2003-03-27 2004-12-30 Cierra, Inc. Methods and apparatus for treatment of patent foramen ovale
US20050021016A1 (en) * 2003-03-27 2005-01-27 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US20050080406A1 (en) * 2003-03-27 2005-04-14 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US20060074410A1 (en) * 2004-06-21 2006-04-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US20060184143A1 (en) * 2001-10-24 2006-08-17 Med-El Elektromedizinische Geraete Gmbh Implantable fluid delivery apparatuses and implantable electrode
US20060271089A1 (en) * 2005-04-11 2006-11-30 Cierra, Inc. Methods and apparatus to achieve a closure of a layered tissue defect
US20070044811A1 (en) * 2003-03-27 2007-03-01 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US20070088335A1 (en) * 2001-10-24 2007-04-19 Med-El Elektromedizinische Geraete Gmbh Implantable neuro-stimulation electrode with fluid reservoir
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US20080312646A9 (en) 2008-12-18 application
US20050033288A1 (en) 2005-02-10 application
US20070203479A1 (en) 2007-08-30 application
US20040243122A1 (en) 2004-12-02 application
US20080009859A1 (en) 2008-01-10 application
US8052677B2 (en) 2011-11-08 grant
US8021359B2 (en) 2011-09-20 grant

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