US20070055261A1 - Systems and methods for creating cavities in interior body regions by propagation of energy - Google Patents

Systems and methods for creating cavities in interior body regions by propagation of energy Download PDF

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Publication number
US20070055261A1
US20070055261A1 US11527798 US52779806A US2007055261A1 US 20070055261 A1 US20070055261 A1 US 20070055261A1 US 11527798 US11527798 US 11527798 US 52779806 A US52779806 A US 52779806A US 2007055261 A1 US2007055261 A1 US 2007055261A1
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Prior art keywords
fig
tool
bone
cavity
structure
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Abandoned
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US11527798
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Mark Reiley
Arie Scholten
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Orthophoenix LLC
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Medtronic Spine LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/164Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans intramedullary
    • AHUMAN NECESSITIES
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    • A61B17/16Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/1662Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for particular parts of the body
    • A61B17/1671Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for particular parts of the body for the spine
    • AHUMAN NECESSITIES
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    • A61B17/22004Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/4601Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
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    • A61B17/1644Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans using fluid other than turbine drive fluid
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    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802Equipment for handling bone cement or other fluid fillers
    • A61B17/8805Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
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    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/24Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
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    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238Type of minimally invasive operation
    • A61B2017/00261Discectomy
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    • A61B17/22004Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B2017/22014Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire
    • AHUMAN NECESSITIES
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    • A61B2017/320733Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a flexible cutting or scraping element, e.g. with a whip-like distal filament member
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
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    • A61F2/4603Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2/4611Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
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    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30581Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
    • A61F2002/30583Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid filled with hardenable fluid, e.g. curable in-situ
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
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    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0085Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof hardenable in situ, e.g. epoxy resins

Abstract

An energy transmitter is introduced into a bone, e.g., a vertebral body, through a percutaneous path. Energy is propagated into the bone by the energy transmitter to create a cavity in the bone. A material is conveyed into the cavity. The material can be, e.g., a bone cement, allograft material, synthetic bone substitute, a medication, or a flowable material that sets into a hardened condition.

Description

    RELATED APPLICATIONS
  • [0001]
    This application is a divisional of application Ser. No. 10/958,944, filed Oct. 5, 2004, and entitled “Structures and Methods for Creating Cavities in Interior Body Regions,” which is a divisional of application Ser. No. 10/208,391, filed Jul. 30, 2002 (now U.S. Pat. No. 6,863,672), which is a divisional of application Ser. No. 09/055,805, filed Apr. 6, 1998 (now U.S. Pat. No. 6,440,138), each of which is incorporated herein by reference.
  • FIELD OF THE INVENTION
  • [0002]
    The invention relates to structures and procedures, which, in use, form cavities in interior body regions of humans and other animals for diagnostic or therapeutic purposes.
  • BACKGROUND OF THE INVENTION
  • [0003]
    Certain diagnostic or therapeutic procedures require the formation of a cavity in an interior body region.
  • [0004]
    For example, as disclosed in U.S. Pat. Nos. 4,969,888 and 5,108,404, an expandable body is deployed to form a cavity in cancellous bone tissue, as part of a therapeutic procedure that fixes fractures or other abnormal bone conditions, both osteoporotic and non-osteoporotic in origin. The expandable body compresses the cancellous bone to form an interior cavity. The cavity receives a filling material, which provides renewed interior structural support for cortical bone.
  • [0005]
    This procedure can be used to treat cortical bone, which due to osteoporosis, avascular necrosis, cancer, or trauma, is fractured or is prone to compression fracture or collapse. These conditions, if not successfully treated, can result in deformities, chronic complications, and an overall adverse impact upon the quality of life.
  • [0006]
    A demand exists for alternative systems or methods which, like the expandable body shown in U.S. Pat. Nos. 4,969,888 and 5,108,404, are capable of forming cavities in bone and other interior body regions in safe and efficacious ways.
  • SUMMARY OF THE INVENTION
  • [0007]
    One aspect of the invention provides a system comprising an access tool sized and configured to establish an access path through soft tissue to bone having an interior volume occupied, at least in part, by cancellous bone. The system also includes a cavity forming tool sized and configured to be introduced through the access path. The cavity forming tool includes an energy transmitter sized and configured to form a cavity in cancellous bone by propagation of energy from an energy source. The system further includes a filling device sized to be introduced through a percutaneous access path for conveying a material into the cavity.
  • [0008]
    Another aspect of the invention provides a method that introduces an energy transmitter into a bone through a percutaneous path. The method propagates an energy into the bone through the energy transmitter and creates a cavity in the bone. The method conveys a material into the cavity. The material can comprise at least one of a bone cement, allograft material, synthetic bone substitute, a medication, or a flowable material that sets into a hardened condition.
  • [0009]
    In one embodiment, the bone is a vertebral body.
  • [0010]
    Features and advantages of the inventions are set forth in the following Description and Drawings, as well as in the appended Claims.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0011]
    FIG. 1 is a side view of a rotatable tool having a loop structure capable of forming a cavity in tissue, with the loop structure deployed beyond the associated catheter tube;
  • [0012]
    FIG. 1A is an enlarged end view of the tool shown in FIG. 1;
  • [0013]
    FIG. 2 is a side view of the tool shown in FIG. 1, with the loop structure retracted within the catheter tube;
  • [0014]
    FIG. 3 is a side view of the tool shown in FIG. 1, with the loop structure deployed beyond the catheter tube to a greater extent than shown in FIG. 1;
  • [0015]
    FIG. 4 is a side view of the tool shown in FIG. 1 inserted within a guide sheath for deployment in a targeted treatment area;
  • [0016]
    FIG. 5 is a side view of another rotatable tool having a brush structure capable of forming a cavity in tissue, with the brush structure deployed beyond the associated drive tube;
  • [0017]
    FIG. 5A is an enlarged end view of the tool shown in FIG. 5;
  • [0018]
    FIG. 6 is a side view of the tool shown in FIG. 5, with the brush structure retracted within the drive tube;
  • [0019]
    FIG. 7 is a side view of the tool shown in FIG. 5, with the brush structure deployed beyond the catheter tube to a greater extent than shown in FIG. 5, and with the brush structure being rotated to cause the associated bristles to flare outward;
  • [0020]
    FIG. 8 is a side view of the tool shown in FIG. 7, with the brush structure deployed beyond the catheter tube to a greater extent than shown in FIG. 7, and with the brush structure still being rotated to cause the associated bristles to flare outward;
  • [0021]
    FIG. 9 is a side view of an alternative tool having an array of bristles carried by a flexible shaft, which is capable of forming a cavity in tissue;
  • [0022]
    FIG. 10 is a side view of the tool shown in FIG. 9 as it is being deployed inside a cannula;
  • [0023]
    FIG. 11 is the tool shown in FIG. 9 when deployed in a soft tissue region bounded by hard tissue;
  • [0024]
    FIG. 12 is a side view of a tool having a rotatable blade structure capable of forming a cavity in tissue;
  • [0025]
    FIG. 13 is a side view of an alternative curved blade structure that the tool shown in FIG. 12 can incorporate;
  • [0026]
    FIG. 14 is a side view of an alternative ring blade structure that the tool shown in FIG. 12 can incorporate;
  • [0027]
    FIG. 15 is a side view of the ring blade structure shown in FIG. 14 while being introduced through a cannula;
  • [0028]
    FIG. 16 is a side view of a rotating tool capable of forming a cavity in tissue, with an associated lumen to introduce a rinsing liquid and aspirate debris;
  • [0029]
    FIG. 17 is a perspective side view of a tool having a linear movement blade structure capable of forming a cavity in tissue, with the blade structure deployed beyond the associated catheter tube in an operative position for use;
  • [0030]
    FIG. 18 is an end view of the tool shown in FIG. 17, with the blade structure shown in its operative position for use;
  • [0031]
    FIG. 19 is an end view of the tool shown in FIG. 17, with the blade structure shown in its rest position within the catheter tube;
  • [0032]
    FIG. 20 is a side view of the tool shown in FIG. 17, with the blade structure shown in its rest position within the catheter tube, as also shown in an end view in FIG. 18;
  • [0033]
    FIG. 21 is a side view of the tool shown in FIG. 17, with the blade structure deployed beyond the associated catheter tube in an operative position for use, as also shown in an end view in FIG. 18;
  • [0034]
    FIG. 22 is a side view of a tool having a linear movement energy transmitter capable of forming a cavity in tissue, with the energy transmitter deployed beyond the associated catheter tube in an operative position for use;
  • [0035]
    FIG. 23 is a top view of a human vertebra, with portions removed to reveal cancellous bone within the vertebral body, and with a guide sheath located for postero-lateral access;
  • [0036]
    FIG. 24 is a side view of the vertebra shown in FIG. 23;
  • [0037]
    FIG. 25 is a top view of the vertebra shown in FIG. 23, with the tool shown in FIG. 1 deployed to cut cancellous bone by rotating the loop structure, thereby forming a cavity;
  • [0038]
    FIG. 26 is a top view of the vertebra shown in FIG. 23, with the tool shown in FIG. 5 deployed to cut cancellous bone by rotating the brush structure, thereby forming a cavity;
  • [0039]
    FIG. 27 is a side view of the vertebra shown in FIG. 23, with the tool shown in FIG. 17 deployed to cut cancellous bone by moving the blade structure in a linear path, thereby forming a cavity;
  • [0040]
    FIG. 28 is a side view of the vertebra shown in FIG. 23, with the tool shown in FIG. 22 deployed to cut cancellous bone using an energy transmitter, which is both rotatable and movable in a linear path, thereby forming a cavity;
  • [0041]
    FIG. 29 is a side view of the vertebra shown in FIG. 23, after formation of a cavity by use of one of the tools shown in FIGS. 25 to 28, and with a second tool deployed to introduce material into the cavity for therapeutic purposes;
  • [0042]
    FIG. 30 is a plan view of a sterile kit to store a single use cavity forming tool of a type previously shown; and
  • [0043]
    FIG. 31 is an exploded perspective view of the sterile kit shown in FIG. 30.
  • [0044]
    The invention may be embodied in several forms without departing from its spirit or essential characteristics. The scope of the invention is defined in the appended claims, rather than in the specific description preceding them. All embodiments that fall within the meaning and range of equivalency of the claims are therefore intended to be embraced by the claims.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • [0045]
    The systems and methods embodying the invention can be adapted for use virtually in any interior body region, where the formation of a cavity within tissue is required for a therapeutic or diagnostic purpose. The preferred embodiments show the invention in association with systems and methods used to treat bones. This is because the systems and methods which embody the invention are well suited for use in this environment. It should be appreciated that the systems and methods which embody features of the invention can be used in other interior body regions, as well.
  • [0000]
    I. Rotatable Cavity Forming Structures
  • [0046]
    A. Rotatable Loop Structure
  • [0047]
    FIG. 1 shows a rotatable tool 10 capable of forming a cavity in a targeted treatment area. The tool 10 comprises a catheter tube 12 having a proximal and a distal end, respectively 14 and 16. The catheter tube 12 preferable includes a handle 18 to aid in gripping and maneuvering the tube 12. The handle 18 can be made of a foam material secured about the catheter tube 12.
  • [0048]
    The catheter tube 12 carries a cavity forming structure 20 at its distal end 16. In the illustrated embodiment, the structure 20 comprises a filament 22 of resilient inert material, which is bent back upon itself and preformed with resilient memory to form a loop.
  • [0049]
    The material from which the filament 22 is made can be resilient, inert wire, like stainless steel. Alternatively, resilient injection molded inert plastic or shape memory material, like nickel titanium (commercially available as Nitinol™ material), can also be used. The filament 22 can, in cross section, be round, rectilinear, or an other configuration.
  • [0050]
    As FIG. 1A shows, the filament 22 radiates from slots 24 in a base 26 carried by the distal end 16 of the catheter tube 12. The free ends 28 of the filament 22 extend through the catheter tube 12 and are connected to a slide controller 30 near the handle 18.
  • [0051]
    As FIG. 2 shows, sliding the controller 30 aft (arrow A) retracts the filament 22 through the slots 24, which progressively decreases the dimensions of the loop structure 20. As FIG. 2 shows, in its farthest aft position, the filament 22 is essentially fully withdrawn and does not project a significant distance beyond the distal end 16 of the catheter tube 12.
  • [0052]
    As FIG. 3 shows, sliding the controller 30 forward (arrow F) advances the filament 22 through the slots 24. The loop structure 20 forms, which projects beyond the distal end 16 of the catheter tube 12. As it is advanced progressively forward through the slots 24, the dimensions of the loop structure 20 progressively increase (compare FIG. 1 to FIG. 3). The controller 30 can include indicia 32, through which the physician can estimate the dimensions of the loop structure 20.
  • [0053]
    In use (see FIG. 4), the catheter tube 12 is carried for axial and rotational movement within a guide sheath or cannula 34. The physician is able to freely slide the catheter tube 12 axially within the guide sheath 34 (arrow S in FIG. 4). As FIG. 4 shows, when fully confined by the guide sheath 34, the loop structure 20, if projecting a significant distance beyond the distal end 16, is collapsed by the surrounding sheath 34. When free of the guide sheath 34, the loop structure 20 springs open to assume its normal dimension. Thereafter, the physician can operate the controller 30 to alter the dimension of the loop structure 20 at will.
  • [0054]
    When free of the guide sheath 34, the physician is also able to rotate the deployed loop structure 20, by rotating the catheter tube 12 within the guide sheath 34 (arrow R in FIG. 4). As will be described in greater detail alter, rotation of the loop structure 20 slices or cut through surrounding tissue mass.
  • [0055]
    The materials for the catheter tube 12 are selected to facilitate advancement and rotation of the loop structure 20. The catheter tube 12 can be constructed, for example, using standard flexible, medical grade plastic materials, like vinyl, nylon, polyethylenes, ionomer, polyurethane, and polyethylene tetraphthalate (PET). The catheter tube 12 can also include more rigid materials to impart greater stiffness and thereby aid in its manipulation and torque transmission capabilities. More rigid materials that can be used for this purpose include stainless steel, nickel-titanium alloys (Nitinol™ material), and other metal alloys.
  • [0056]
    The filament 22 preferably carries one or more radiological markers 36. The markers 36 are made from known radiopaque materials, like platinum, gold, calcium, tantalum, and other heavy metals. At least one marker 36 is placed at or near the distal extremity of the loop structure 20, while other markets can be placed at spaced apart locations on the loop structure 20. The distal end 16 of the catheter tube 12 can also carry markers. The markers 36 permit radiologic visualization of the loop structure 20 and catheter tube 12 within the targeted treatment area.
  • [0057]
    Of course, other forms of markers can be used to allow the physician to visualize the location and shape of the loop structure 20 within the targeted treatment area.
  • [0058]
    B. Rotatable Brush
  • [0059]
    FIG. 5 shows an alternative embodiment of a rotatable tool 38 capable of forming a cavity in a targeted treatment area. The tool 38 comprises a drive shaft 40, which is made from stiffer materials for good torsion transmission capabilities, e.g., stainless steel, nickel-titanium alloys (Nitinol™ material), and other metal alloys.
  • [0060]
    The distal end 42 of the drive shaft carries a cavity forming structure 44, which comprises an array of filaments forming bristles 46. As FIG. 5A shows, the bristles 46 extend from spaced-apart slots 48 in a base 50 carried by the distal end 42 of the drive shaft 40.
  • [0061]
    The material from which the bristles 46 is made can be stainless steel, or injection molded inert plastic, or shape memory material, like nickel titanium. The bristles 46 can, in cross section, be round, rectilinear, or an other configuration.
  • [0062]
    The proximal end 52 of the drive shaft 40 carries a fitting 54 that, in use, is coupled to an electric motor 56 for rotating the drive shaft 40, and, with it, the bristles 46 (arrows R in FIGS. 7 and 8). When rotated by the motor 46, the bristles spread apart (as FIG. 7 shows), under the influence of centrifugal force, forming a brush-like structure 44. The brush structure 44, when rotating, cuts surrounding tissue mass in the targeted treatment area.
  • [0063]
    The free ends 58 of the bristles 46 extend through the drive shaft 40 and are commonly connected to a slide controller 60. As FIG. 6 shows, sliding the controller 60 aft (arrow A in FIG. 6) shortens the distance the bristles 46 extend from the base 50. As FIGS. 7 and 8 show, sliding the controller 60 forward (arrow F in FIG. 8) lengthens the extension distance of the bristles 46. Using the controller 60, the physician is able to adjust the dimension of the cutting area (compare FIG. 7 and FIG. 8).
  • [0064]
    The array of bristles 46 preferably includes one or more radiological markers 62, as previously described. The markers 62 allow radiologic visualization of the brush structure 44 while in use within the targeted treatment area. The controller 60 can also include indicia 64 by which the physician can visually estimate the bristle extension distance. The distal end 42 of the drive shaft 40 can also carry one or more markers 62.
  • [0065]
    The drive shaft 40 of the tool 38 is, in use, carried for axial and rotational movement within the guide sheath or cannula 34, in the same manner shown for the tool 10 in FIG. 4. The physician is able to freely slide the drive shaft 40 axially within the guide sheath to deploy it in the targeted treatment area. Once connected to the drive motor 56, the drive shaft 40 is free to rotate within the guide sheath 34 to form the brush structure 44.
  • [0066]
    FIG. 9 shows an alternative embodiment of a rotatable tool 138 having an array of filaments forming bristles 140, which is capable of forming a cavity in a targeted treatment area. The tool 138 includes a flexible drive shaft 142, which is made, e.g., from twisted wire filaments, such stainless steel, nickel-titanium alloys (Nitinol™ material), and other metal alloys.
  • [0067]
    The bristles 140 radially extend from the drive shaft 142, near its distal end. The bristles 140 can be made, e.g., from resilient stainless steel, or injection molded inert plastic, or shape memory material, like nickel titanium. The bristles 140 can, in cross section, be round, rectilinear, or an other configuration.
  • [0068]
    As FIG. 10 shows, the tool 138 is introduced into the targeted tissue region through a cannula 144. When in the cannula 144, the resilient bristles 140 are compressed rearward to a low profile, enabling passage through the cannula. When free of the cannula 144, the resilient bristles 140 spring radially outward, ready for use.
  • [0069]
    The proximal end of the drive shaft 142 carries a fitting 146 that, in use, is coupled to an electric motor 148. The motor 148 rotates the drive shaft 142 (arrow R in FIG. 11), and, with it, the bristles 140.
  • [0070]
    As FIG. 11 shows, when deployed inside an interior body cavity with soft tissue S (e.g., cancellous bone bounded by hard tissue H (e.g., cortical bone), the physician can guide the tool 138 through the soft tissue S by allowing the rotating bristles 140 to ride against the adjoining hard tissue H. The flexible drive shaft 142 bends to follow the contour of the hard tissue H, while the rotating bristles 140 cut adjoining soft tissue S, forming a cavity C.
  • [0071]
    In the illustrated embodiment, the drive shaft 142 carries a pitched blade 151 at its distal end. The blade 151 rotates with the drive shaft 142. By engaging tissue, the blade 151 generates a forward-pulling force, which helps to advance the drive shaft 142 and bristles 140 through the soft tissue mass.
  • [0072]
    In the illustrated embodiment, the bristles 140, or the cannula 144, or both include one or more radiological markers 153, as previously described. The markers 153 allow radiologic visualization of the bristles 140 while rotating and advancing within the targeted treatment area.
  • [0073]
    C. Rotatable Blade Structure
  • [0074]
    FIG. 12 shows an alternative embodiment of a rotatable tool 106 capable of forming a cavity in a targeted treatment area. The tool 106, like the tool 38, comprises a generally stiff drive shaft 108, made from, e.g., stainless steel, nickel-titanium alloys (Nitinol™ material), and other metal alloys, for good torsion transmission capabilities.
  • [0075]
    The distal end of the drive shaft 108 carries a cavity forming structure 110, which comprises a cutting blade. The blade 110 can take various shapes.
  • [0076]
    In FIGS. 12 and 13, the blade 110 is generally L-shaped, having a main leg 112 and a short leg 116. In the illustrated embodiment, the main leg 112 of the blade 110 is pitched radially forward of the drive shaft axis 114, at a small forward angle beyond perpendicular to the drive shaft. The main leg 112 may possess a generally straight configuration (as FIG. 12 shows), or, alternatively, it may present a generally curved surface (as FIG. 13 shows). In the illustrated embodiment, the short leg 116 of the blade 110 is also pitched at a small forward angle from the main leg 112, somewhat greater than perpendicular.
  • [0077]
    In FIG. 14, the blade 110 takes the shape of a continuous ring 126. As illustrated, the ring 126 is pitched slightly forward, e.g., at an angle slightly greater than perpendicular relative to the drive shaft axis 114.
  • [0078]
    The material from which the blade 110 is made can be stainless steel, or injection molded inert plastic. The legs 112 and 116 of the blade 110 shown in FIGS. 12 and 13, and the ring 126 shown in FIG. 14, can, in cross section, be round, rectilinear, or another configuration.
  • [0079]
    When rotated (arrow R), the blade 110 cuts a generally cylindrical path through surrounding tissue mass. The forward pitch of the blade 110 reduces torque and provides stability and control as the blade 110 advances, while rotating, through the tissue mass.
  • [0080]
    Rotation of the blade 110 can be accomplished manually or at higher speed by use of a motor. In the illustrated embodiment, the proximal end of the drive shaft 108 of the tool 106 carries a fitting 118. The fitting 118 is coupled to an electric motor 120 to rotate the drive shaft 108, and, with it, the blade 110.
  • [0081]
    As FIG. 15 shows, the drive shaft 108 of the tool 108 is deployed subcutaneously into the targeted tissue area through a guide sheath or cannula 124. Connected to the drive motor 120, the drive shaft 108 rotates within the guide sheath 34, thereby rotating the blade 110 to cut a cylindrical path P in the surrounding tissue mass TM. The blade 110 can be advanced and retracted, while rotating, in a reciprocal path (arrows F and A), by applying pushing and pulling forces upon the drive shaft 108. The blade 110 can also be withdrawn into the cannula 124 to allow changing of the orientation of the cannula 124. In this way, successive cylindrical paths can be cut through the tissue mass, through rotating and reciprocating the blade 110, to thereby create a desired cavity shape.
  • [0082]
    The blade 110, or the end of the cannula 124, or both can carry one or more radiological markers 122, as previously described. The markers 122 allow radiologic visualization of the blade 110 and its position relative to the cannula 34 while in use within the targeted treatment area.
  • [0083]
    D. Rinsing and Aspiration
  • [0084]
    As FIG. 16 shows, any of the tools 10, 38, 106, or 138 can include an interior lumen 128. The lumen 128 is coupled via a Y-valve 132 to a external source 130 of fluid and an external vacuum source 134.
  • [0085]
    A rinsing liquid 136, e.g., sterile saline, can be introduced from the source 130 through the lumen 128 into the targeted tissue region as the tools 10, 38, or 106 rotate and cut the tissue mass TM. The rinsing liquid 136 reduces friction and conducts heat away from the tissue during the cutting operation. The rinsing liquid 136 can be introduced continuously or intermittently while the tissue mass is being cut. The rinsing liquid 136 can also carry an anticoagulant or other anti-clotting agent.
  • [0086]
    By periodically coupling the lumen 128 to the vacuum source 134, liquids and debris can be aspirated from the targeted tissue region through the lumen 128.
  • [0000]
    II. Linear Movement Cavity Forming Structures
  • [0087]
    A. Cutting Blade
  • [0088]
    FIGS. 17 to 21 show a linear movement tool 66 capable of forming a cavity in a targeted treatment area. Like the tool 10, the tool 66 comprises a catheter tube 68 having a handle 70 (see FIG. 20) on its proximal end 72 to facilitate gripping and maneuvering the tube 68.
  • [0089]
    The catheter tube 68 carries a linear movement cavity forming structure 74 at its distal end 76. In the illustrated embodiment, the structure 56 comprises a generally rigid blade 78, which projects at a side angle from the distal end 76 (see FIGS. 17 and 21). The blade 78 can be formed from stainless steel or cast or molded plastic.
  • [0090]
    A stylet 80 is carried by an interior track 82 within the catheter tube 68 (see FIGS. 18 and 19). The track 82 extends along the axis of the catheter tube 68. The stylet 80 is free to move in a linear aft path (arrow A in FIG. 20) and a linear forward path (arrow F in FIG. 21) within the track 82. The stylet 80 is also free to rotate within the track 82 (arrow R in FIG. 17).
  • [0091]
    The far end of the stylet 80 is coupled to the blade 78. The near end of the stylet 80 carries a control knob 84. By rotating the control knob 84, the physician rotates the blade 78 between an at rest position, shown in FIGS. 19 and 20, and an operating position, shown in FIGS. 17, 18, and 21. When in the at rest position, the physician can push or pull upon the control knob 84 to move the blade 78 in a linear path within the catheter tube (see FIG. 20). By pushing on the control knob 84, the physician can move the blade 78 outside the catheter tube 68, where it can be rotated into the operating condition (see FIG. 21). When in the operating position, pushing and pulling on the control knob 84 moves the blade in linear strokes against surrounding tissue mass.
  • [0092]
    In use, the catheter tube 68 is also carried for sliding and rotation within the guide sheath or cannula 34, in the same manner shown in FIG. 4. The physician is able to freely slide the catheter tube 68 axially within the guide sheath 34 to deploy the tool 66 in the targeted treatment site. When deployed at the site, the physician can deploy the blade 78 in the operating condition outside the catheter tube 68 and slide the blade 78 along tissue in a linear path. Linear movement of the blade 78 along tissue cuts the tissue. The physician is also able to rotate both the catheter tube 68 within the guide sheath 34 and the blade 78 within the catheter tube 68 to adjust the orientation and travel path of the blade 78.
  • [0093]
    The blade 78 can carry one or more radiological markers 86, as previously described, to allow radiologic visualization of the blade 78 within the targeted treatment area. Indicia 88 on the stylet 80 can also allow the physician to visually approximate the extent of linear or rotational movement of the blade 78. The distal end 76 of the catheter tube 68 can also carry one or more markers 86.
  • [0094]
    B. Energy Transmitters
  • [0095]
    FIG. 22 shows an alternative embodiment of a linear movement tool 90 capable of forming a cavity in a targeted treatment area. The tool 90 is physically constructed in the same way as the linear movement tool 66 just described, so common reference numerals are assigned.
  • [0096]
    However, for the tool 90 shown FIG. 22, the far end of the stylet 80 carries, not a cutting blade 78, but instead a transmitter 92 capable of transmitting energy that cuts tissue (shown by lines 100 in FIG. 22). A connector 94 couples the transmitter 92 to a source 96 of the energy, through a suitable energy controller 98.
  • [0097]
    The type of energy 100 that the transmitter 92 propagates to remove tissue in the targeted treatment area can vary. For example, the transmitter 92 can propagate ultrasonic energy at harmonic frequencies suitable for cutting the targeted tissue. Alternatively, the transmitter 92 can propagate laser energy at a suitable tissue cutting frequency.
  • [0098]
    As before described, the near end of the stylet 80 includes a control knob 84. Using the control knob 84, the physician is able to move the transmitter 92 in a linear path (arrows A and F in FIG. 22) between a retracted position, housed with the catheter tube 68 (like the blade 78 shown in FIG. 20), and a range of extended positions outside the catheter tube 68, as shown in FIG. 22).
  • [0099]
    As also described before, the catheter tube 68 of the tool 90 is, in use, carried for sliding and rotation within the guide sheath or cannula 34. The physician slides the catheter tube 68 axially within the guide sheath 34 for deployment of the tool 90 at the targeted treatment site. When deployed at the site, the physician operates the control knob 84 to linearly move and rotate the transmitter 92 to achieve a desired position in the targeted treatment area. The physician can also rotate the catheter tube 68 and thereby further adjust the location of the transmitter 92.
  • [0100]
    The transmitter 92 or stylet 80 can carry one or more radiological markers 86, as previously described, to allow radiologic visualization of the position of the transmitter 92 within the targeted treatment area. Indicia 88 on the stylet 80 can also allow the physician to visually estimate the position of the transmitter 92. The distal end 76 of the catheter tube 68 can also carry one or more markers 86.
  • [0000]
    III. Use of Cavity Forming Tools
  • [0101]
    Use of the various tools 10 (FIGS. 1 to 4), 38 (FIGS. 5 to 8), 138 (FIGS. 9 to 11), 106 (FIGS. 12 to 15), 66 (FIGS. 17 to 21), and 90 (FIG. 22) will now be described in the context of deployment in a human vertebra 150.
  • [0102]
    FIG. 23 shows the vertebra 150 in coronal (top) view, and FIG. 24 shows the vertebra 150 in lateral (side) view. It should be appreciated, however, the tool is not limited in its application to vertebrae. The tools 10, 38, 138, 106, 66, and 90 can be deployed equally as well in long bones and other bone types.
  • [0103]
    As FIGS. 23 and 24 show, the vertebra 150 includes a vertebral body 152, which extends on the anterior (i.e., front or chest) side of the vertebra 150. The vertebral body 152 includes an exterior formed from compact cortical bone 158. The cortical bone 158 encloses an interior volume of reticulated cancellous, or spongy, bone 160 (also called medullary bone or trabecular bone).
  • [0104]
    The vertebral body 152 is in the shape of an oval disk. As FIGS. 23 and 24 show, access to the interior volume of the vertebral body 152 can be achieved. e.g., by drilling an access portal 162 through a side of the vertebral body 152, which is called a postero-lateral approach. The portal 162 for the postero-lateral approach enters at a posterior side of the body 152 and extends at angle forwardly toward the anterior of the body 152. The portal 162 can be performed either with a closed, minimally invasive procedure or with an open procedure.
  • [0105]
    Alternatively, access into the interior volume can be accomplished by drilling an access portal through either pedicle 164 (identified in FIG. 23). This is called a transpedicular approach. It is the physician who ultimately decides which access site is indicated.
  • [0106]
    As FIGS. 23 and 24 show, the guide sheath 34 (earlier shown in FIG. 4) is located in the access portal 162. Under radiologic or CT monitoring, a selected one of the tools 10, 38, 66, or 90 can be introduced through the guide sheath 34.
  • [0107]
    A. Deployment and Use of the Loop Tool in a Vertebral Body
  • [0108]
    When, for example, the loop tool 10 is used, the loop structure 20 is, if extended, collapsed by the guide sheath 34 (as shown in FIG. 4), or otherwise retracted within the catheter tube 12 (as FIG. 2 shows) during passage through the guide sheath 34.
  • [0109]
    Referring to FIG. 25, when the loop tool 10 is deployed outside the guide sheath 34 in the cancellous bone 160, the physician operates the controller 30 in the manner previously described to obtain a desired dimension for the loop structure 20, which can be gauged by radiologic monitoring using the on-board markers 36. The physician manually rotates the loop structure 20 through surrounding cancellous bone 160 (as indicated by arrows R in FIG. 25). The rotating loop structure 20 cuts cancellous bone 160 and thereby forms a cavity C. A suction tube 102, also deployed through the guide sheath 34, removes cancellous bone cut by the loop structure 20. Alternatively, the catheter tube 12 can include an interior lumen 128 (as shown in FIG. 16) to serve as a suction tube as well as to convey a rinsing liquid into the cavity as it is being formed.
  • [0110]
    Synchronous rotation and operation of the controller 30 to enlarge the dimensions of the loop structure 20 during the procedure allows the physician to achieve a create a cavity C of desired dimension. Representative dimensions for a cavity C will be discussed in greater detail later.
  • [0111]
    B. Deployment and Use of the Brush Tool in a Vertebral Body
  • [0112]
    When, for example, the brush tool 38 is used, the physician preferable withdraws the bristles 46 during their passage through the guide sheath 34, in the manner shown in FIG. 6.
  • [0113]
    Referring to FIG. 26, when the brush tool 38 is deployed in cancellous bone 160 free of the guide sheath 34, the physician advances the bristles 46 a desired distance (as shown in FIG. 5), aided by radiologic monitoring of the markers 62, or the indicia 32 previously described, or both. The physician connects the drive shaft 40 to the motor 56 to rotate the bristles 46, creating the brush structure 44. As FIG. 26 shows, the rotating brush structure 44 cuts cancellous bone 160 and forms a cavity C. The suction tube 102 (or a lumen 128 in the drive shaft 40, as shown in FIG. 16) introduces a rinsing fluid (with an anticoagulant, if desired) and removes cancellous bone cut by the brush structure 44. By periodically stopping rotation of the brush structure 44 and operating the controller 60 (previously described) to increase the forward extension of the bristles 46, the physician able over time to create a cavity C having the desired dimensions.
  • [0114]
    C. Deployment and use of the Linear Tools in a Vertebral Body
  • [0115]
    When, for example, one of the linear movement tools 66 or 90 are used, the physician preferable withdraws the blade 78 or the transmitter 92 into the catheter tube 68 in the manner shown in FIG. 20, until the distal end 76 of the catheter tube 68 is free of the guide sheath 34.
  • [0116]
    Referring to FIG. 27, using the blade tool 66, the physician operates the stylet 80 forward (arrow F) and aft (arrow A) to move the blade 78 in a linear path through cancellous bone 160. The blade 78 scrapes loose and cuts cancellous bone 160 along its path, which the suction tube 102 removes. A cavity C is thereby formed. Synchronous rotation (arrow R) and linear movement (arrows F and A) of the blade 78 allow the physician to create a cavity C having a desired dimension.
  • [0117]
    Referring to FIG. 28, using the energy transmitting tool 90, the physician rotates (arrow R) and pushes or pulls upon the stylet 80 (arrows F and A) to position the energy transmitter 92 at desired locations in cancellous bone 160. The markers 86 aid the location process. Transmission by the transmitter 92 of the selected energy cuts cancellous bone 160 for removal by the suction tube 102. A cavity C is thereby formed. Through purposeful maneuvering of the transmitter 92, the physician achieves a cavity C having the desired dimension.
  • [0118]
    D. Deployment of Other Tools into the Cavity
  • [0119]
    Once the desired cavity C is formed, the selected tool 10, 38, 66, 90, 106, or 138 is withdrawn through the guide sheath 34. As FIG. 29 shows, an other tool 104 can now be deployed through the guide sheath 34 into the formed cavity C. The second tool 104 can, for example, perform a diagnostic procedure. Alternatively, the second tool 104 can perform a therapeutic procedure, e.g., by dispensing a material 106 into the cavity C, such as, e.g., bone cement, allograft material, synthetic bone substitute, a medication, or a flowable material that sets to a hardened condition. Further details of the injection of such materials 106 into the cavity C for therapeutic purposes are found in U.S. Pat. Nos. 4,969,888 and 5,108,404 and in copending U.S. patent application Ser. No. 08/485,394, which are incorporated herein by reference.
  • [0120]
    E. Bone Cavity Dimensions
  • [0121]
    The size of the cavity C varies according to the therapeutic or diagnostic procedure performed.
  • [0122]
    At least about 30% of the cancellous bone volume needs to be removed in cases where the bone disease causing fracture (or the risk of fracture) is the loss of cancellous bone mass (as in osteoporosis). The preferred range is about 30% to 90% of the cancellous bone volume. Removal of less of the cancellous bone volume can leave too much of the diseased cancellous bone at the treated site. The diseased cancellous bone remains weak and can later collapse, causing fracture, despite treatment.
  • [0123]
    However, there are times when a lesser amount of cancellous bone removal is indicated. For example, when the bone disease being treated is localized, such as in avascular necrosis, or where local loss of blood supply is killing bone in a limited area, the selected tool 10, 38, 66, 90, 106, or 138 can remove a smaller volume of total bone. This is because the diseased area requiring treatment is smaller.
  • [0124]
    Another exception lies in the use of a selected tool 10, 36, 66, 90, 106, or 138 to improve insertion of solid materials in defined shapes, like hydroxyapatite and components in total joint replacement. In these cases, the amount of tissue that needs to be removed is defined by the size of the material being inserted.
  • [0125]
    Yet another exception lays the use of a selected tool 10, 36, 66, 90, 106, or 138 in bones to create cavities to aid in the delivery of therapeutic substances, as disclosed in copending U.S. patent application Ser. No. 08/485,394. In this case, the cancellous bone may or may not be diseased or adversely affected. Healthy cancellous bone can be sacrificed by significant compaction to improve the delivery of a drug or growth factor which has an important therapeutic purpose. In this application, the size of the cavity is chosen by the desired amount of therapeutic substance sought to be delivered. In this case, the bone with the drug inside is supported while the drug works, and the bone heals through exterior casting or current interior or exterior fixation devices.
  • [0000]
    IV. Single Use Sterile Kit
  • [0126]
    A single use of any one of the tools 10, 38, 138, 106, 66, or 90 creates contact with surrounding cortical and cancellous bone. This contact can damage the tools, creating localized regions of weakness, which may escape detection. The existence of localized regions of weakness can unpredictably cause overall structural failure during a subsequent use.
  • [0127]
    In addition, exposure to blood and tissue during a single use can entrap biological components on or within the tools. Despite cleaning and subsequent sterilization, the presence of entrapped biological components can lead to unacceptable pyrogenic reactions.
  • [0128]
    As a result, following first use, the tools may not meet established performance and sterilization specifications. The effects of material stress and damage caused during a single use, coupled with the possibility of pyrogen reactions even after resterilization, reasonably justify imposing a single use restriction upon the tools for deployment in bone.
  • [0129]
    To protect patients from the potential adverse consequences occasioned by multiple use, which include disease transmission, or material stress and instability, or decreased or unpredictable performance, each single use tool 10, 38, 66, 90, 106, or 138 is packaged in a sterile kit 500 (see FIGS. 30 and 31) prior to deployment in bone.
  • [0130]
    As FIGS. 30 and 31 show, the kit 500 includes an interior tray 508. The tray 508 holds the particular cavity forming tool (generically designated 502) in a lay-flat, straightened condition during sterilization and storage prior to its first use. The tray 508 can be formed from die cut cardboard or thermoformed plastic material. The tray 508 includes one or more spaced apart tabs 510, which hold the tool 502 in the desired lay-flat, straightened condition.
  • [0131]
    The kit 500 includes an inner wrap 512, which is peripherally sealed by heat or the like, to enclose the tray 508 from contact with the outside environment. One end of the inner wrap 512 includes a conventional peal-away seal 514 (see FIG. 31), to provide quick access to the tray 508 upon instance of use, which preferably occurs in a sterile environment, such as within an operating room.
  • [0132]
    The kit 500 also includes an outer wrap 516, which is also peripherally sealed by heat or the like, to enclosed the inner wrap 512. One end of the outer wrap 516 includes a conventional peal-away seal 518 (see FIG. 31), to provide access to the inner wrap 512, which can be removed from the outer wrap 516 in anticipation of imminent use of the tool 502, without compromising sterility of the tool 502 itself.
  • [0133]
    Both inner and outer wraps 512 and 516 (see FIG. 31) each includes a peripherally sealed top sheet 520 and bottom sheet 522. In the illustrated embodiment, the top sheet 520 is made of transparent plastic film, like polyethylene or MYLAR™ material, to allow visual identification of the contents of the kit 500. The bottom sheet 522 is made from a material that is permeable to EtO sterilization gas, e.g., TYVEC™ plastic material (available from DuPont).
  • [0134]
    The sterile kit 500 also carries a label or insert 506, which includes the statement “For Single Patient Use Only” (or comparable language) to affirmatively caution against reuse of the contents of the kit 500. The label 506 also preferably affirmatively instructs against resterilization of the tool 502. The label 506 also preferably instructs the physician or user to dispose of the tool 502 and the entire contents of the kit 500 upon use in accordance with applicable biological waste procedures. The presence of the tool 502 packaged in the kit 500 verifies to the physician or user that the tool 502 is sterile and has not be subjected to prior use. The physician or user is thereby assured that the tool 502 meets established performance and sterility specifications, and will have the desired configuration when expanded for use.
  • [0135]
    The kit 500 also preferably includes directions for use 524, which instruct the physician regarding the use of the tool 502 for creating a cavity in cancellous bone in the manners previously described. For example, the directions 524 instruct the physician to deploy and manipulate the tool 502 inside bone to cut cancellous bone and form a cavity. The directions 524 can also instruct the physician to fill the cavity with a material, e.g., bone cement, allograft material, synthetic bone substitute, a medication, or a flowable material that sets to a hardened condition.
  • [0136]
    The features of the invention are set forth in the following claims.

Claims (17)

  1. 1. A system comprising
    an access tool sized and configured to establish an access path through soft tissue to bone having an interior volume occupied, at least in part, by cancellous bone, and
    a cavity forming tool sized and configured to be introduced through the access path including an energy transmitter sized and configured to form a cavity in cancellous bone by propagation of energy from an energy source, and
    a filling device sized to be introduced through a percutaneous access path for conveying a material into the cavity.
  2. 2. A system according to claim 1
    wherein propagation of energy by the energy transmitter cuts cancellous bone to form the cavity.
  3. 3. A system according to claim 1
    wherein the energy transmitter is sized and configured to propagate ultrasound energy.
  4. 4. A system according to claim 1
    wherein the energy transmitter is sized and configured to propagate laser energy.
  5. 5. A system according to claim 1
    wherein the cavity forming tool includes a controller coupled to the energy transmitter to move the energy transmitter between a retracted position housed within the cavity forming tool and at least one extended position outside the cavity forming tool.
  6. 6. A system according to claim 1
    wherein the cavity forming device includes an elongated shaft having a proximal end portion and a distal end portion, the distal end portion carrying the energy transmitter, the shaft including a material capable of transmitting axial and rotational forces from the proximal end portion to the distal end portion in response to manipulation of the proximal end portion.
  7. 7. A system according to claim 1
    wherein the material conveyed by the filling device into the cavity comprises at least one of a bone cement, allograft material, synthetic bone substitute, a medication, or a flowable material that sets into a hardened condition.
  8. 8. A system according to claim 1
    wherein the cavity forming tool includes at least one radiopaque marker adjacent the energy transmitter.
  9. 9. A system according to claim 1
    further including a connector to couple the energy transmitter to the energy source.
  10. 10. A method comprising
    providing a system as defined in claim 1,
    introducing the cavity forming tool through the access tool into a cortical bone space occupied at least in part by cancellous bone,
    operating the energy transmitter to propagate energy and form a cavity in cancellous bone, and
    conveying material through the filling device into the cavity.
  11. 11. A method according to claim 10
    wherein the material conveyed into the cavity comprises at least one of a bone cement, allograft material, synthetic bone substitute, a medication, or a flowable material that sets into a hardened condition.
  12. 12. A method comprising
    introducing an energy transmitter into a bone through a percutaneous path,
    propagating an energy into the bone through the energy transmitter;
    creating a cavity in the bone by the propagation of energy, and
    conveying a material into the cavity.
  13. 13. A method according to claim 12
    wherein the material conveyed into the cavity comprises at least one of a bone cement, allograft material, synthetic bone substitute, a medication, or a flowable material that sets into a hardened condition.
  14. 14. A method comprising
    selecting a vertebral body for treatment having a cortical wall enclosing a cancellous bone volume,
    providing a system as define in claim 1,
    introducing the cavity forming tool through the access tool into the cancellous bone volume,
    operating the energy transmitter to propagate energy and form a cavity in the cancellous bone volume, and
    conveying material through the filling device into the cavity.
  15. 15. A method according to claim 14
    wherein the material conveyed into the cavity comprises at least one of a bone cement, allograft material, synthetic bone substitute, a medication, or a flowable material that sets into a hardened condition.
  16. 16. A method comprising
    introducing an energy transmitter into a vertebral body through a percutaneous path,
    propagating an energy into the vertebral body through the energy transmitter,
    creating a cavity in the vertebral body by the propagation of energy, and
    conveying a material into the cavity.
  17. 17. A method according to claim 16
    wherein the material conveyed into the cavity comprises at least one of a bone cement, allograft material, synthetic bone substitute, a medication, or a flowable material that sets into a hardened condition.
US11527798 1998-04-06 2006-09-27 Systems and methods for creating cavities in interior body regions by propagation of energy Abandoned US20070055261A1 (en)

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US09055805 US6440138B1 (en) 1998-04-06 1998-04-06 Structures and methods for creating cavities in interior body regions
US10208391 US6863672B2 (en) 1998-04-06 2002-07-30 Structures and methods for creating cavities in interior body regions
US10958944 US20050043737A1 (en) 1998-04-06 2004-10-05 Structures for creating cavities in interior body regions
US11527798 US20070055261A1 (en) 1998-04-06 2006-09-27 Systems and methods for creating cavities in interior body regions by propagation of energy

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US11527798 US20070055261A1 (en) 1998-04-06 2006-09-27 Systems and methods for creating cavities in interior body regions by propagation of energy

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US20070055261A1 true true US20070055261A1 (en) 2007-03-08

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US09055805 Expired - Lifetime US6440138B1 (en) 1998-04-06 1998-04-06 Structures and methods for creating cavities in interior body regions
US10208391 Expired - Lifetime US6863672B2 (en) 1998-04-06 2002-07-30 Structures and methods for creating cavities in interior body regions
US10958944 Abandoned US20050043737A1 (en) 1998-04-06 2004-10-05 Structures for creating cavities in interior body regions
US11527798 Abandoned US20070055261A1 (en) 1998-04-06 2006-09-27 Systems and methods for creating cavities in interior body regions by propagation of energy
US11789225 Active 2020-05-04 US7909827B2 (en) 1998-04-06 2007-04-24 Systems and methods for creating cavities in interior body regions
US11789226 Abandoned US20070198020A1 (en) 1998-04-06 2007-04-24 Apparatus and method for creating cavities in interior body regions
US11978825 Active 2019-03-29 US7879038B2 (en) 1998-04-06 2007-10-30 Apparatus, kits, and methods for creating cavities in cancellous bone using an elongated loop structure or bristles

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US09055805 Expired - Lifetime US6440138B1 (en) 1998-04-06 1998-04-06 Structures and methods for creating cavities in interior body regions
US10208391 Expired - Lifetime US6863672B2 (en) 1998-04-06 2002-07-30 Structures and methods for creating cavities in interior body regions
US10958944 Abandoned US20050043737A1 (en) 1998-04-06 2004-10-05 Structures for creating cavities in interior body regions

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US11789225 Active 2020-05-04 US7909827B2 (en) 1998-04-06 2007-04-24 Systems and methods for creating cavities in interior body regions
US11789226 Abandoned US20070198020A1 (en) 1998-04-06 2007-04-24 Apparatus and method for creating cavities in interior body regions
US11978825 Active 2019-03-29 US7879038B2 (en) 1998-04-06 2007-10-30 Apparatus, kits, and methods for creating cavities in cancellous bone using an elongated loop structure or bristles

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JP (3) JP4250743B2 (en)
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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060184192A1 (en) * 2005-02-11 2006-08-17 Markworth Aaron D Systems and methods for providing cavities in interior body regions
US20080009875A1 (en) * 2006-07-07 2008-01-10 Meera Sankaran Medical device with dual expansion mechanism
WO2009048681A2 (en) * 2007-08-06 2009-04-16 The Regents Of The University Of California Methods of tissue-based diagnosis
US20090270892A1 (en) * 2008-04-25 2009-10-29 Greg Arcenio Steerable medical device for tissue disruption
US20090270893A1 (en) * 2008-04-25 2009-10-29 Greg Arcenio Medical device for tissue disruption with serrated expandable portion
US20090270862A1 (en) * 2008-04-25 2009-10-29 Greg Arcenio Medical device with one-way rotary drive mechanism
US20100030216A1 (en) * 2008-07-30 2010-02-04 Arcenio Gregory B Discectomy tool having counter-rotating nucleus disruptors
US20100160921A1 (en) * 2008-12-19 2010-06-24 Arthrocare Corporation Cancellous bone displacement system and methods of use
WO2010093861A2 (en) * 2009-02-13 2010-08-19 The Regents Of The University Of Calfornia System, method and device for tissue-based diagnosis
US7909873B2 (en) 2006-12-15 2011-03-22 Soteira, Inc. Delivery apparatus and methods for vertebrostenting
US8389582B2 (en) 2007-08-06 2013-03-05 Samir Mitragotri Composition for solubilizing tissue comprising 3-(decyl dimethyl ammonio) propane sulfonate and tetraethylene glycol dodecyl ether
US8609041B2 (en) 2007-08-06 2013-12-17 Samir Mitragotri Apparatus for solubilizing tissue
US8642664B2 (en) 2007-08-06 2014-02-04 Samir Mitragotri Composition for solubilizing tissue and cells comprising N-tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate and polyoxyethylene (10) cetyl ether
US9192397B2 (en) 2006-12-15 2015-11-24 Gmedelaware 2 Llc Devices and methods for fracture reduction
US9220554B2 (en) 2010-02-18 2015-12-29 Globus Medical, Inc. Methods and apparatus for treating vertebral fractures
US9480485B2 (en) 2006-12-15 2016-11-01 Globus Medical, Inc. Devices and methods for vertebrostenting
US9814422B2 (en) 2007-08-06 2017-11-14 The Regents Of The University Of California Compositions for solubilizing cells and/or tissue

Families Citing this family (283)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248110B1 (en) * 1994-01-26 2001-06-19 Kyphon, Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
US6719773B1 (en) 1998-06-01 2004-04-13 Kyphon Inc. Expandable structures for deployment in interior body regions
US6440138B1 (en) * 1998-04-06 2002-08-27 Kyphon Inc. Structures and methods for creating cavities in interior body regions
DE69942858D1 (en) 1998-06-01 2010-11-25 Kyphon S A R L Expandable, preformed structures for folding in regions within the body
US6241734B1 (en) 1998-08-14 2001-06-05 Kyphon, Inc. Systems and methods for placing materials into bone
US6716216B1 (en) * 1998-08-14 2004-04-06 Kyphon Inc. Systems and methods for treating vertebral bodies
JP2004535249A (en) * 1998-10-26 2004-11-25 エクスパンディング オーソペディクス インコーポレーテッド Expandable orthopedic equipment
US6805697B1 (en) * 1999-05-07 2004-10-19 University Of Virginia Patent Foundation Method and system for fusing a spinal region
WO2001050973A1 (en) * 1999-12-24 2001-07-19 Lee Hee Young Mandibular angle fracture operating method and its devices
DE60321720D1 (en) 2000-02-16 2008-07-31 Trans1 Inc Apparatus for wirbelsäulendistraktion and fusion
US20080033466A1 (en) * 2006-02-28 2008-02-07 Trans1 Inc. Surgical cutter with exchangeable cutter blades
US6558390B2 (en) 2000-02-16 2003-05-06 Axiamed, Inc. Methods and apparatus for performing therapeutic procedures in the spine
US7641657B2 (en) 2003-06-10 2010-01-05 Trans1, Inc. Method and apparatus for providing posterior or anterior trans-sacral access to spinal vertebrae
US7776042B2 (en) * 2002-12-03 2010-08-17 Trans1 Inc. Methods and apparatus for provision of therapy to adjacent motion segments
US6790210B1 (en) * 2000-02-16 2004-09-14 Trans1, Inc. Methods and apparatus for forming curved axial bores through spinal vertebrae
US7727263B2 (en) 2000-02-16 2010-06-01 Trans1, Inc. Articulating spinal implant
US7632274B2 (en) * 2000-02-16 2009-12-15 Trans1 Inc. Thin cutter blades with retaining film for preparing intervertebral disc spaces
US20030191474A1 (en) * 2000-02-16 2003-10-09 Cragg Andrew H. Apparatus for performing a discectomy through a trans-sacral axial bore within the vertebrae of the spine
US20070260270A1 (en) * 2000-02-16 2007-11-08 Trans1 Inc. Cutter for preparing intervertebral disc space
EP1263336B1 (en) * 2000-03-10 2004-02-18 Radius Medical Technologies, Inc. Surgical snare apparatus
WO2001076514A3 (en) * 2000-04-05 2002-05-02 Joseph J Basista Methods and devices for treating fractured and/or diseased bone
US7815649B2 (en) * 2000-04-07 2010-10-19 Kyphon SÀRL Insertion devices and method of use
KR20080091284A (en) 2000-04-07 2008-10-09 메드트로닉 스파인 엘엘씨 Insertion devices and method of use
DE60100949D1 (en) * 2000-04-11 2003-11-13 Bone Support Ab Lund containing bone cement Injiezierbares bone substitute material and oil
US6506214B1 (en) 2000-05-02 2003-01-14 R. Michael Gross Method and means for cementing a liner onto the face of the glenoid cavity of a scapula
EP1303236B1 (en) 2000-07-14 2008-12-03 Kyphon SARL Systems for treating vertebral bodies
US7417077B2 (en) * 2000-07-17 2008-08-26 Bone Support Ab Composition for an injectable bone mineral substitute material
US7114501B2 (en) * 2000-08-14 2006-10-03 Spine Wave, Inc. Transverse cavity device and method
US6679886B2 (en) 2000-09-01 2004-01-20 Synthes (Usa) Tools and methods for creating cavities in bone
US7153306B2 (en) * 2000-10-25 2006-12-26 Kyphon Inc. Systems and methods for reducing fractured bone using a fracture reduction cannula
US6632235B2 (en) 2001-04-19 2003-10-14 Synthes (U.S.A.) Inflatable device and method for reducing fractures in bone and in treating the spine
US6814739B2 (en) 2001-05-18 2004-11-09 U.S. Endoscopy Group, Inc. Retrieval device
US6746451B2 (en) * 2001-06-01 2004-06-08 Lance M. Middleton Tissue cavitation device and method
US6726685B2 (en) * 2001-06-06 2004-04-27 Oratec Interventions, Inc. Intervertebral disc device employing looped probe
US6814734B2 (en) * 2001-06-18 2004-11-09 Sdgi Holdings, Inc, Surgical instrumentation and method for forming a passage in bone having an enlarged cross-sectional portion
US20030032963A1 (en) * 2001-10-24 2003-02-13 Kyphon Inc. Devices and methods using an expandable body with internal restraint for compressing cancellous bone
US7799833B2 (en) 2001-11-01 2010-09-21 Spine Wave, Inc. System and method for the pretreatment of the endplates of an intervertebral disc
EP1448089A4 (en) * 2001-11-01 2008-06-04 Spine Wave Inc Devices and methods for the restoration of a spinal disc
DE10154163A1 (en) 2001-11-03 2003-05-22 Advanced Med Tech An apparatus for raising and stabilizing the spine
US6783533B2 (en) 2001-11-21 2004-08-31 Sythes Ag Chur Attachable/detachable reaming head for surgical reamer
JP4824908B2 (en) * 2001-12-20 2011-11-30 ボーン サポート アクチボラゲット New bone mineral substitute
US7641667B2 (en) * 2002-01-29 2010-01-05 Smith & Nephew, Inc. Tissue cutting instrument
EP1515641B1 (en) * 2002-06-04 2016-09-14 The Board of Trustees of the Leland Stanford Junior University Device for rapid aspiration and collection of body tissue from within an enclosed body space
US7901407B2 (en) * 2002-08-02 2011-03-08 Boston Scientific Scimed, Inc. Media delivery device for bone structures
WO2004024005A1 (en) * 2002-09-11 2004-03-25 Nuvasive, Inc. Systems and methods for removing body tissue
US8613744B2 (en) 2002-09-30 2013-12-24 Relievant Medsystems, Inc. Systems and methods for navigating an instrument through bone
US6907884B2 (en) 2002-09-30 2005-06-21 Depay Acromed, Inc. Method of straddling an intraosseous nerve
US8361067B2 (en) 2002-09-30 2013-01-29 Relievant Medsystems, Inc. Methods of therapeutically heating a vertebral body to treat back pain
US8808284B2 (en) 2008-09-26 2014-08-19 Relievant Medsystems, Inc. Systems for navigating an instrument through bone
US20160278791A1 (en) 2008-09-26 2016-09-29 Relievant Medsystems, Inc. Intraosseous nerve modulation methods
US20120289859A9 (en) * 2003-08-27 2012-11-15 Nicoson Zachary R System and method for minimally invasive disease therapy
US8123698B2 (en) * 2002-10-07 2012-02-28 Suros Surgical Systems, Inc. System and method for minimally invasive disease therapy
US8172770B2 (en) * 2005-09-28 2012-05-08 Suros Surgical Systems, Inc. System and method for minimally invasive disease therapy
WO2004043271A1 (en) * 2002-11-08 2004-05-27 Sdgi Holdings, Inc. Transpedicular intervertebral disk access methods and devices
CA2505468A1 (en) * 2002-11-21 2004-06-10 Sdgi Holdings, Inc. Systems and techniques for interbody spinal stablization with expandable devices
WO2004047689A1 (en) * 2002-11-21 2004-06-10 Sdgi Holdings, Inc. Systems and techniques for intravertebral spinal stablization with expandable devices
KR200306716Y1 (en) * 2002-11-29 2003-03-11 (주)오티스바이오텍 Apparatus operating backbone
US7749228B2 (en) 2002-12-27 2010-07-06 The Cleveland Clinic Foundation Articulatable apparatus for cutting bone
DE602004018903D1 (en) 2003-02-14 2009-02-26 Depuy Spine Inc intervertebral fusion device prepared in situ
CN100536932C (en) * 2003-03-05 2009-09-09 骨维护股份公司 A new bone substitute composition
US7258690B2 (en) 2003-03-28 2007-08-21 Relievant Medsystems, Inc. Windowed thermal ablation probe
US7175628B2 (en) * 2003-05-21 2007-02-13 Crosstrees Medical, Inc. Extractable filler for inserting medicine into animal tissue
US7175627B2 (en) * 2003-05-21 2007-02-13 Crosstrees Medical, Inc. Extractable filler for inserting medicine into animal tissue
WO2004107955A3 (en) * 2003-05-30 2008-01-17 Frank Nguyen Methods and devices for transpedicular discectomy
US20050010231A1 (en) * 2003-06-20 2005-01-13 Myers Thomas H. Method and apparatus for strengthening the biomechanical properties of implants
US20050043796A1 (en) * 2003-07-01 2005-02-24 Grant Richard L. Spinal disc nucleus implant
CA2537048C (en) * 2003-09-03 2010-01-12 Kyphon Inc. Devices for creating voids in interior body regions and related methods
US8276091B2 (en) * 2003-09-16 2012-09-25 Ram Consulting Haptic response system and method of use
US7175629B2 (en) * 2003-09-29 2007-02-13 Crosstrees Medical, Inc. Extractable filler for inserting medicine into vertebral body
WO2005041793A3 (en) 2003-10-23 2005-11-10 Steven D Ainsworth Spinal mobility preservation apparatus and method
JP2007516738A (en) 2003-10-23 2007-06-28 トランスワン インコーポレイティッド Tools and tool kits for performing minimal intrusion process to the spine
CN1878516B (en) * 2003-11-11 2011-02-16 骨支撑股份公司 Device for providing spongy bone with bone substitute and/or bone reinforcing material
US7524103B2 (en) * 2003-11-18 2009-04-28 Boston Scientific Scimed, Inc. Apparatus for mixing and dispensing a multi-component bone cement
US7789912B2 (en) 2004-01-08 2010-09-07 Spine Wave, Inc. Apparatus and method for injecting fluent material at a distracted tissue site
CA2552727A1 (en) 2004-01-16 2005-08-04 Expanding Orthopedics, Inc. Bone fracture treatment devices
FR2865382B1 (en) * 2004-01-23 2007-01-05 Sem Sa femoral stem for hip prosthesis and set of tools for its removal
US20050165487A1 (en) 2004-01-28 2005-07-28 Muhanna Nabil L. Artificial intervertebral disc
US7641664B2 (en) 2004-02-12 2010-01-05 Warsaw Orthopedic, Inc. Surgical instrumentation and method for treatment of a spinal structure
US7959634B2 (en) 2004-03-29 2011-06-14 Soteira Inc. Orthopedic surgery access devices
EP1748739A1 (en) * 2004-05-19 2007-02-07 Sintea Biotech S.p.A. Intravertebral widening device, injection device , and kit and method for kyphoplasty
US20080255560A1 (en) * 2004-05-21 2008-10-16 Myers Surgical Solutions, Llc Fracture Fixation and Site Stabilization System
US8142462B2 (en) 2004-05-28 2012-03-27 Cavitech, Llc Instruments and methods for reducing and stabilizing bone fractures
US8328810B2 (en) * 2004-06-17 2012-12-11 Boston Scientific Scimed, Inc. Slidable sheaths for tissue removal devices
CN102120156A (en) 2004-06-22 2011-07-13 骨支撑股份公司 Device for receiving and discharging a hardenable mass
US7789913B2 (en) 2004-06-29 2010-09-07 Spine Wave, Inc. Methods for injecting a curable biomaterial into an intervertebral space
US20080319445A9 (en) * 2004-08-17 2008-12-25 Scimed Life Systems, Inc. Apparatus and methods for delivering compounds into vertebrae for vertebroplasty
US8038682B2 (en) * 2004-08-17 2011-10-18 Boston Scientific Scimed, Inc. Apparatus and methods for delivering compounds into vertebrae for vertebroplasty
EP1793769A4 (en) * 2004-09-02 2009-06-24 Crosstrees Medical Inc Device and method for distraction of the spinal disc space
US7682378B2 (en) * 2004-11-10 2010-03-23 Dfine, Inc. Bone treatment systems and methods for introducing an abrading structure to abrade bone
US20060100706A1 (en) * 2004-11-10 2006-05-11 Shadduck John H Stent systems and methods for spine treatment
US7799078B2 (en) * 2004-11-12 2010-09-21 Warsaw Orthopedic, Inc. Implantable vertebral lift
US8562607B2 (en) 2004-11-19 2013-10-22 Dfine, Inc. Bone treatment systems and methods
DE202004019105U1 (en) * 2004-12-10 2005-02-24 Stryker Trauma Gmbh Apparatus for clearing bone cavities
JP5159320B2 (en) * 2005-01-07 2013-03-06 セロノバ バイオサイエンシーズ, インコーポレイテッド Three-dimensional implantable bone support
US8628534B2 (en) * 2005-02-02 2014-01-14 DePuy Synthes Products, LLC Ultrasonic cutting device
KR101121387B1 (en) * 2005-03-07 2012-03-09 헥터 오. 파체코 System and method for improved access to the vertebral body in the spine hugul percutaneous balloon reversal, percutaneous vertebroplasty, vertebral body biopsy or screw arrangement
US20060235418A1 (en) * 2005-04-13 2006-10-19 Sdgi Holdings, Inc. Method and device for preparing a surface for receiving an implant
US8070756B2 (en) * 2005-04-15 2011-12-06 U.S. Endoscopy Group, Inc. Polypectomy device and method of use
US20060264896A1 (en) * 2005-05-09 2006-11-23 Palmer Erika I Minimally invasive apparatus and method for treatment of a tumor associated with a bone
US9060820B2 (en) 2005-05-18 2015-06-23 Sonoma Orthopedic Products, Inc. Segmented intramedullary fracture fixation devices and methods
US8961516B2 (en) * 2005-05-18 2015-02-24 Sonoma Orthopedic Products, Inc. Straight intramedullary fracture fixation devices and methods
US20070005075A1 (en) * 2005-06-17 2007-01-04 Bogert Roy B Telescoping plunger assembly
US20070093899A1 (en) * 2005-09-28 2007-04-26 Christof Dutoit Apparatus and methods for treating bone
US20070010845A1 (en) * 2005-07-08 2007-01-11 Gorman Gong Directionally controlled expandable device and methods for use
US20070010844A1 (en) * 2005-07-08 2007-01-11 Gorman Gong Radiopaque expandable body and methods
US20070055276A1 (en) * 2005-07-11 2007-03-08 Edidin Avram A Systems and methods for inserting biocompatible filler materials in interior body regions
US20070006692A1 (en) * 2005-07-11 2007-01-11 Phan Christopher U Torque limiting device
US20070010824A1 (en) * 2005-07-11 2007-01-11 Hugues Malandain Products, systems and methods for delivering material to bone and other internal body parts
EP1909658A2 (en) * 2005-07-11 2008-04-16 Kyphon Inc. Systems and methods for providing cavities in interior body regions
US20070060935A1 (en) * 2005-07-11 2007-03-15 Schwardt Jeffrey D Apparatus and methods of tissue removal within a spine
US8105236B2 (en) * 2005-07-11 2012-01-31 Kyphon Sarl Surgical access device, system, and methods of use
US8021365B2 (en) * 2005-07-11 2011-09-20 Kyphon Sarl Surgical device having interchangeable components and methods of use
US20070068329A1 (en) * 2005-07-11 2007-03-29 Phan Christopher U Curette system
US20070010848A1 (en) * 2005-07-11 2007-01-11 Andrea Leung Systems and methods for providing cavities in interior body regions
US20070149990A1 (en) * 2005-07-11 2007-06-28 Palmer Erika I Apparatus and methods of tissue removal within a spine
US8016834B2 (en) * 2005-08-03 2011-09-13 Helmut Weber Process and device for treating vertebral bodies
US7785368B2 (en) 2005-08-16 2010-08-31 Benvenue Medical, Inc. Spinal tissue distraction devices
US8366773B2 (en) 2005-08-16 2013-02-05 Benvenue Medical, Inc. Apparatus and method for treating bone
US20070055259A1 (en) * 2005-08-17 2007-03-08 Norton Britt K Apparatus and methods for removal of intervertebral disc tissues
FR2889813B1 (en) * 2005-08-18 2008-06-06 Assist Publ Hopitaux De Paris intracerebral sensor and processing device of neurological or psychiatric dysfunctions
US8998923B2 (en) 2005-08-31 2015-04-07 Spinealign Medical, Inc. Threaded bone filling material plunger
US20070067034A1 (en) * 2005-08-31 2007-03-22 Chirico Paul E Implantable devices and methods for treating micro-architecture deterioration of bone tissue
US20070233148A1 (en) * 2005-09-01 2007-10-04 Csaba Truckai Systems and methods for delivering bone fill material and controlling the temperature thereof
US20070123877A1 (en) * 2005-11-15 2007-05-31 Aoi Medical, Inc. Inflatable Device for Restoring Anatomy of Fractured Bone
CA2627248A1 (en) * 2005-11-18 2007-05-24 Apexum Ltd. Ablating apparatus particularly useful for removal of dental periapical lesions
US7799035B2 (en) * 2005-11-18 2010-09-21 Carefusion 2200, Inc. Device, system and method for delivering a curable material into bone
US7713273B2 (en) * 2005-11-18 2010-05-11 Carefusion 2200, Inc. Device, system and method for delivering a curable material into bone
USD669168S1 (en) 2005-11-18 2012-10-16 Carefusion 2200, Inc. Vertebral augmentation needle
US8690884B2 (en) 2005-11-18 2014-04-08 Carefusion 2200, Inc. Multistate-curvature device and method for delivering a curable material into bone
EP1968505A4 (en) * 2005-11-23 2011-12-28 Crosstrees Medical Inc Devices and methods for the treatment of bone fracture
US7927361B2 (en) * 2005-11-29 2011-04-19 Medtronic Xomed, Inc. Method and apparatus for removing material from an intervertebral disc space, such as in performing a nucleotomy
US20070162062A1 (en) * 2005-12-08 2007-07-12 Norton Britt K Reciprocating apparatus and methods for removal of intervertebral disc tissues
US20070162132A1 (en) 2005-12-23 2007-07-12 Dominique Messerli Flexible elongated chain implant and method of supporting body tissue with same
US7901409B2 (en) * 2006-01-20 2011-03-08 Canaveral Villegas Living Trust Intramedullar devices and methods to reduce and/or fix damaged bone
US20070213641A1 (en) * 2006-02-08 2007-09-13 Sdgi Holdings, Inc. Constrained balloon disc sizer
US20070213822A1 (en) 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Treatment of the vertebral column
US20070233258A1 (en) * 2006-02-28 2007-10-04 Zimmer Spine, Inc. Vertebroplasty- device and method
JP2009131290A (en) * 2006-03-08 2009-06-18 Yoshitsugu Terauchi Dental instrument for removing broken piece using flexible guide plate
US9155574B2 (en) 2006-05-17 2015-10-13 Sonoma Orthopedic Products, Inc. Bone fixation device, tools and methods
US8480673B2 (en) * 2006-06-01 2013-07-09 Osteo Innovations Llc Cavity creation device and methods of use
US8814870B2 (en) * 2006-06-14 2014-08-26 Misonix, Incorporated Hook shaped ultrasonic cutting blade
US8506636B2 (en) 2006-09-08 2013-08-13 Theken Spine, Llc Offset radius lordosis
US20080077150A1 (en) * 2006-09-22 2008-03-27 Linh Nguyen Steerable rasp/trial member inserter and method of use
US20080086142A1 (en) * 2006-10-06 2008-04-10 Kohm Andrew C Products and Methods for Delivery of Material to Bone and Other Internal Body Parts
US7963967B1 (en) 2006-10-12 2011-06-21 Woodse Enterprises, Inc. Bone preparation tool
US20080091207A1 (en) * 2006-10-13 2008-04-17 Csaba Truckai Bone treatment systems and methods
US8137352B2 (en) 2006-10-16 2012-03-20 Depuy Spine, Inc. Expandable intervertebral tool system and method
US20080114364A1 (en) * 2006-11-15 2008-05-15 Aoi Medical, Inc. Tissue cavitation device and method
WO2008064346A3 (en) 2006-11-22 2008-12-11 Sonoma Orthopedic Products Inc Fracture fixation device, tools and methods
WO2008067557A9 (en) 2006-11-30 2008-12-11 Urovalve Inc System and method for implanting a catheter
US20080140080A1 (en) * 2006-12-12 2008-06-12 Bernhard Strehl Instrument to make openings in bone in the form of a bone lid
US8486082B2 (en) * 2006-12-13 2013-07-16 Replication Medical, Inc. Apparatus for dimensioning circumference of cavity for introduction of a prosthetic implant
US9028520B2 (en) 2006-12-22 2015-05-12 The Spectranetics Corporation Tissue separating systems and methods
US8961551B2 (en) 2006-12-22 2015-02-24 The Spectranetics Corporation Retractable separating systems and methods
US7972382B2 (en) 2006-12-26 2011-07-05 Warsaw Orthopedic, Inc. Minimally invasive spinal distraction devices and methods
US8828000B2 (en) * 2007-02-13 2014-09-09 The Board Of Regents Of The University Of Texas System Apparatus to trace and cut a tendon or other laterally extended anatomical structure
EP2124777A4 (en) 2007-02-21 2013-06-05 Benvenue Medical Inc Devices for treating the spine
EP2124778A4 (en) 2007-02-21 2013-03-20 Benvenue Medical Inc Devices for treating the spine
EP2162078A4 (en) * 2007-03-06 2011-04-06 Orthobond Inc Preparation tools and methods of using the same
US8206391B2 (en) * 2007-03-07 2012-06-26 Vertech, Inc. Expandable blade device for stabilizing compression fractures
CA2678517A1 (en) * 2007-03-12 2008-09-18 Kieran P. Murphy Method and kit for intra osseous navigation and augmentation of bone
WO2008118945A1 (en) * 2007-03-26 2008-10-02 Spineology, Inc. Articulating shaper
US20080255624A1 (en) * 2007-03-30 2008-10-16 Gregory Arcenio Methods and devices for multipoint access of a body part
WO2008124533A1 (en) * 2007-04-03 2008-10-16 Dfine, Inc. Bone treatment systems and methods
EP2164405A2 (en) * 2007-05-21 2010-03-24 AOI Medical Inc. Articulating cavitation device
US8038679B2 (en) * 2007-05-23 2011-10-18 Stryker Trauma Gmbh Reaming device
US8591521B2 (en) 2007-06-08 2013-11-26 United States Endoscopy Group, Inc. Retrieval device
WO2009036466A1 (en) * 2007-09-14 2009-03-19 Crosstrees Medical, Inc. Material control device for inserting material into a targeted anatomical region
US20090082780A1 (en) * 2007-09-26 2009-03-26 Wilson-Cook Medical Inc Wire capture surgical device with fixable handle
US8597301B2 (en) * 2007-10-19 2013-12-03 David Mitchell Cannula with lateral access and directional exit port
US9510885B2 (en) 2007-11-16 2016-12-06 Osseon Llc Steerable and curvable cavity creation system
US20090131886A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system
CA2705709C (en) * 2007-11-16 2016-03-15 Synthes Usa, Llc Porous containment device and associated method for stabilization of vertebral compression fractures
US20090131950A1 (en) * 2007-11-16 2009-05-21 Liu Y King Vertebroplasty method with enhanced control
US20090131867A1 (en) * 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system with cavity creation element
US20090299282A1 (en) * 2007-11-16 2009-12-03 Osseon Therapeutics, Inc. Steerable vertebroplasty system with a plurality of cavity creation elements
WO2009073209A1 (en) * 2007-12-06 2009-06-11 Osseon Therapeutics, Inc. Vertebroplasty implant with enhanced interfacial shear strength
US8282648B2 (en) * 2007-12-19 2012-10-09 Cook Medical Technologies Llc Bone cement needle
US20090177206A1 (en) * 2008-01-08 2009-07-09 Zimmer Spine, Inc. Instruments, implants, and methods for fixation of vertebral compression fractures
US8287538B2 (en) 2008-01-14 2012-10-16 Conventus Orthopaedics, Inc. Apparatus and methods for fracture repair
JP5563485B2 (en) 2008-01-31 2014-07-30 コヴィディエン リミテッド パートナーシップ Polyp removal device and method of use
US20090299401A1 (en) 2008-06-02 2009-12-03 Loma Vista Medical, Inc. Inflatable medical devices
US8277506B2 (en) 2008-06-24 2012-10-02 Carefusion 2200, Inc. Method and structure for stabilizing a vertebral body
US20100168748A1 (en) * 2008-07-16 2010-07-01 Knopp Peter G Morselizer
JP5770087B2 (en) * 2008-07-25 2015-08-26 スパイン ビュー, インコーポレイテッド System and method for cable-based debridement
GB0813818D0 (en) * 2008-07-29 2008-09-03 Depuy Int Ltd An instrument for forming a cavity within a bone
US8246627B2 (en) * 2008-08-07 2012-08-21 Stryker Corporation Cement delivery device for introducing cement into tissue, the device having a cavity creator
JP5688022B2 (en) 2008-09-26 2015-03-25 リリーバント メドシステムズ、インコーポレイテッド Systems and methods for inducing instrument through the interior of the bone
JP5575777B2 (en) 2008-09-30 2014-08-20 ディファイン, インコーポレイテッド System for use in the treatment of vertebral fractures
US8758349B2 (en) 2008-10-13 2014-06-24 Dfine, Inc. Systems for treating a vertebral body
CA2745210C (en) * 2008-12-01 2018-03-13 Mazor Robotics Ltd Robot guided oblique spinal stabilization
WO2010094032A3 (en) 2009-02-16 2010-11-11 Aoi Medical Inc. Trauma nail accumulator
US8535327B2 (en) 2009-03-17 2013-09-17 Benvenue Medical, Inc. Delivery apparatus for use with implantable medical devices
US8911497B2 (en) * 2009-04-09 2014-12-16 DePuy Synthes Products, LLC Minimally invasive spine augmentation and stabilization system and method
US8801739B2 (en) * 2009-04-17 2014-08-12 Spine View, Inc. Devices and methods for arched roof cutters
US20120065695A1 (en) * 2009-04-27 2012-03-15 Keio University Medical wire
US8911474B2 (en) 2009-07-16 2014-12-16 Howmedica Osteonics Corp. Suture anchor implantation instrumentation system
RU2012105452A (en) * 2009-07-24 2013-08-27 Смит Энд Нефью, Инк. Surgical instruments for cutting cavities in the intramedullary canals
US8348966B2 (en) * 2009-08-07 2013-01-08 Thayer Intellectual Property, Inc. Systems and methods for treatment of compressed nerves
US8753364B2 (en) 2009-08-07 2014-06-17 Thayer Intellectual Property, Inc. Systems and methods for treatment of compressed nerves
US8652157B2 (en) 2009-08-07 2014-02-18 Thayer Intellectual Property, Inc. Systems and methods for treatment of compressed nerves
CA2812775C (en) 2009-08-20 2015-09-29 Howmedica Osteonics Corp. Flexible acl instrumentation, kit and method
US8894658B2 (en) 2009-11-10 2014-11-25 Carefusion 2200, Inc. Apparatus and method for stylet-guided vertebral augmentation
WO2011060311A3 (en) 2009-11-13 2011-08-18 Intuitive Surgical Operations, Inc. End effector with redundant closing mechanisms
KR20170129968A (en) * 2009-11-13 2017-11-27 인튜어티브 서지컬 오퍼레이션즈 인코포레이티드 Motor interface for parallel drive shafts within an independently rotating member
US9259275B2 (en) * 2009-11-13 2016-02-16 Intuitive Surgical Operations, Inc. Wrist articulation by linked tension members
KR101847990B1 (en) * 2009-11-13 2018-04-11 인튜어티브 서지컬 오퍼레이션즈 인코포레이티드 Surgical tool with a compact wrist
US8821504B2 (en) 2009-11-20 2014-09-02 Zimmer Knee Creations, Inc. Method for treating joint pain and associated instruments
US9259257B2 (en) 2009-11-20 2016-02-16 Zimmer Knee Creations, Inc. Instruments for targeting a joint defect
US8951261B2 (en) 2009-11-20 2015-02-10 Zimmer Knee Creations, Inc. Subchondral treatment of joint pain
WO2011063260A1 (en) 2009-11-20 2011-05-26 Knee Creations, Llc Bone-derived implantable devices for subchondral treatment of joint pain
WO2011063281A1 (en) 2009-11-20 2011-05-26 Knee Creations, Llc Navigation and positioning instruments for joint repair
EP2501281A4 (en) 2009-11-20 2017-05-31 Zimmer Knee Creations Inc Coordinate mapping system for joint treatment
WO2011063240A1 (en) 2009-11-20 2011-05-26 Knee Creations, Llc Implantable devices for subchondral treatment of joint pain
US8906032B2 (en) 2009-11-20 2014-12-09 Zimmer Knee Creations, Inc. Instruments for a variable angle approach to a joint
US9526538B2 (en) 2009-12-07 2016-12-27 Globus Medical, Inc. Methods and apparatus for treating vertebral fractures
US8734458B2 (en) * 2009-12-07 2014-05-27 Globus Medical, Inc. Methods and apparatus for treating vertebral fractures
US9326799B2 (en) 2009-12-07 2016-05-03 Globus Medical, Inc. Methods and apparatus for treating vertebral fractures
WO2011075745A3 (en) * 2009-12-18 2011-10-20 Palmaz Scientific, Inc. Interosteal and intramedullary implants and method of implanting same
KR20140028063A (en) 2011-05-05 2014-03-07 지가 테크놀로지 인코포레이티드 Sacroiliac fusion system
US8348950B2 (en) * 2010-01-04 2013-01-08 Zyga Technology, Inc. Sacroiliac fusion system
US20110178520A1 (en) 2010-01-15 2011-07-21 Kyle Taylor Rotary-rigid orthopaedic rod
CA2823873A1 (en) 2010-01-20 2011-07-28 Conventus Orthopaedics, Inc. Apparatus and methods for bone access and cavity preparation
US8696672B2 (en) * 2010-01-22 2014-04-15 Baxano Surgical, Inc. Abrading tool for preparing intervertebral disc spaces
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
US20120330293A1 (en) * 2010-02-26 2012-12-27 Keio University Catheter for performing photodynamic ablation of cardiac muscle tissue via photochemical reaction
JP2013521880A (en) 2010-03-08 2013-06-13 コンベンタス オーソピディックス, インコーポレイテッド Apparatus and method for securing a bone implant
US20110251616A1 (en) * 2010-04-12 2011-10-13 K2M, Inc. Expandable reamer and method of use
CN102958456B (en) 2010-04-29 2015-12-16 Dfine有限公司 System for treating vertebral fractures
WO2011137357A1 (en) 2010-04-29 2011-11-03 Dfine, Inc. System for use in treatment of vertebral fractures
US9526507B2 (en) 2010-04-29 2016-12-27 Dfine, Inc. System for use in treatment of vertebral fractures
US8900251B2 (en) 2010-05-28 2014-12-02 Zyga Technology, Inc Radial deployment surgical tool
DK2588154T3 (en) 2010-07-02 2017-11-27 Agnovos Healthcare Llc A composition comprising calcium phosphate, or sulfatpulvere DMB used in the treatment of degenerative bone conditions
WO2012009486A3 (en) 2010-07-13 2012-03-22 Loma Vista Medical, Inc. Inflatable medical devices
USD674489S1 (en) 2010-09-15 2013-01-15 Thayer Intellectual Property, Inc. Handle for a medical device
USD666725S1 (en) 2010-09-15 2012-09-04 Thayer Intellectual Property, Inc. Handle for a medical device
USD673683S1 (en) 2010-09-15 2013-01-01 Thayer Intellectual Property, Inc. Medical device
US8414606B2 (en) 2010-10-22 2013-04-09 Medtronic Xomed, Inc. Method and apparatus for removing material from an intervertebral disc space and preparing end plates
JP5865387B2 (en) 2010-11-22 2016-02-17 ディファイン, インコーポレイテッド System for use in the treatment of vertebral fractures
US9445825B2 (en) 2011-02-10 2016-09-20 Wright Medical Technology, Inc. Expandable surgical device
US9795398B2 (en) 2011-04-13 2017-10-24 Howmedica Osteonics Corp. Flexible ACL instrumentation, kit and method
US8900279B2 (en) 2011-06-09 2014-12-02 Zyga Technology, Inc. Bone screw
US9358065B2 (en) * 2011-06-23 2016-06-07 Covidien Lp Shaped electrode bipolar resection apparatus, system and methods of use
US8814873B2 (en) 2011-06-24 2014-08-26 Benvenue Medical, Inc. Devices and methods for treating bone tissue
US9119639B2 (en) 2011-08-09 2015-09-01 DePuy Synthes Products, Inc. Articulated cavity creator
US8801630B2 (en) * 2011-09-30 2014-08-12 Olympus Medical Systems Corp. Method of taking out liquid present inside subject therefrom
US20130116556A1 (en) * 2011-11-05 2013-05-09 Custom Medical Applications Neural safety injection system and related methods
WO2013096197A1 (en) 2011-12-22 2013-06-27 Depuy Spine, Inc. Length-adjustable vertebral body balloon
CN104470453A (en) 2012-03-27 2015-03-25 Dfine有限公司 Methods and systems for use in controlling tissue ablation volume by temperature monitoring
US8986307B2 (en) 2012-07-10 2015-03-24 X-Spine Systems, Inc. Surgical instrument with pivotable implant holder
US8821494B2 (en) 2012-08-03 2014-09-02 Howmedica Osteonics Corp. Surgical instruments and methods of use
US9724122B2 (en) 2012-09-14 2017-08-08 The Spectranetics Corporation Expandable lead jacket
CA2889478A1 (en) 2012-11-05 2014-05-08 Relievant Medsystems, Inc. Systems and methods for creating curved paths through bone and modulating nerves within the bone
US9358058B2 (en) 2012-11-05 2016-06-07 Globus Medical, Inc. Methods and apparatus for treating vertebral fractures
US9918766B2 (en) 2012-12-12 2018-03-20 Dfine, Inc. Devices, methods and systems for affixing an access device to a vertebral body for the insertion of bone cement
US9241729B2 (en) 2012-12-14 2016-01-26 DePuy Synthes Products, Inc. Device to aid in the deployment of a shape memory instrument
FR3000665B3 (en) * 2013-01-04 2015-07-03 Small Bone Innovations Internat Packaging for a drilling tool or cutting of a bone
US9078740B2 (en) 2013-01-21 2015-07-14 Howmedica Osteonics Corp. Instrumentation and method for positioning and securing a graft
US9192420B2 (en) * 2013-01-24 2015-11-24 Kyphon Sarl Surgical system and methods of use
US9439693B2 (en) 2013-02-01 2016-09-13 DePuy Synthes Products, Inc. Steerable needle assembly for use in vertebral body augmentation
US9402620B2 (en) 2013-03-04 2016-08-02 Howmedica Osteonics Corp. Knotless filamentary fixation devices, assemblies and systems and methods of assembly and use
US9788826B2 (en) 2013-03-11 2017-10-17 Howmedica Osteonics Corp. Filamentary fixation device and assembly and method of assembly, manufacture and use
US9283040B2 (en) 2013-03-13 2016-03-15 The Spectranetics Corporation Device and method of ablative cutting with helical tip
US9456872B2 (en) 2013-03-13 2016-10-04 The Spectranetics Corporation Laser ablation catheter
US9291663B2 (en) 2013-03-13 2016-03-22 The Spectranetics Corporation Alarm for lead insulation abnormality
US9463013B2 (en) 2013-03-13 2016-10-11 Stryker Corporation Adjustable continuous filament structure and method of manufacture and use
US9883885B2 (en) 2013-03-13 2018-02-06 The Spectranetics Corporation System and method of ablative cutting and pulsed vacuum aspiration
WO2014159225A3 (en) 2013-03-14 2014-11-27 Baxano Surgical, Inc. Spinal implants and implantation system
US9295479B2 (en) * 2013-03-14 2016-03-29 Spinal Stabilization Technologies, Llc Surgical device
US9918737B2 (en) 2013-03-15 2018-03-20 The Spectranetics Corporation Medical device for removing an implanted object
US9668765B2 (en) 2013-03-15 2017-06-06 The Spectranetics Corporation Retractable blade for lead removal device
USD770616S1 (en) 2015-02-20 2016-11-01 The Spectranetics Corporation Medical device handle
EP2967634A4 (en) 2013-03-15 2017-02-08 Spectranetics Corp Surgical instrument for removing an implanted object
USD765243S1 (en) 2015-02-20 2016-08-30 The Spectranetics Corporation Medical device handle
US20140330286A1 (en) * 2013-04-25 2014-11-06 Michael P. Wallace Methods and Devices for Removing Obstructing Material From the Human Body
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners
US9539041B2 (en) 2013-09-12 2017-01-10 DePuy Synthes Products, Inc. Minimally invasive biomaterial injection system
US9649128B2 (en) * 2013-12-02 2017-05-16 Novon Solutions, LLC Adjustable curette
WO2015089357A3 (en) * 2013-12-12 2015-11-05 Conventus Orthopaedics, Inc. Tissue displacement tools and methods
US9770278B2 (en) 2014-01-17 2017-09-26 Arthrex, Inc. Dual tip guide wire
US9814499B2 (en) 2014-09-30 2017-11-14 Arthrex, Inc. Intramedullary fracture fixation devices and methods
US9901392B2 (en) 2015-05-11 2018-02-27 Dfine, Inc. System for use in treatment of vertebral fractures
US20170303938A1 (en) 2016-04-25 2017-10-26 Imds Llc Joint fusion instrumentation and methods

Citations (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US383639A (en) * 1888-05-29 Manure-distributer
US817973A (en) * 1904-06-06 1906-04-17 Caspar Friedrich Hausmann Uterine dilator.
US3181533A (en) * 1962-01-15 1965-05-04 William C Heath Surgical snare
US3640280A (en) * 1969-11-26 1972-02-08 Daniel R Slanker Power-driven reciprocating bone surgery instrument
US4024639A (en) * 1975-02-25 1977-05-24 End-Dent, Inc. Bone implants and method for inserting the same
US4203444A (en) * 1977-11-07 1980-05-20 Dyonics, Inc. Surgical instrument suitable for closed surgery such as of the knee
US4204531A (en) * 1977-12-28 1980-05-27 Yacov Aginsky Intramedullary nail with expanding mechanism
US4245359A (en) * 1978-03-28 1981-01-20 Sulzer Brothers Limited Plug for openings produced by operative procedures in medullated bones
US4274163A (en) * 1979-07-16 1981-06-23 The Regents Of The University Of California Prosthetic fixation technique
US4313434A (en) * 1980-10-17 1982-02-02 David Segal Fracture fixation
US4323071A (en) * 1978-04-24 1982-04-06 Advanced Catheter Systems, Inc. Vascular guiding catheter assembly and vascular dilating catheter assembly and a combination thereof and methods of making the same
US4369772A (en) * 1980-04-28 1983-01-25 University Of Florida Method for strengthening a fractured bone
US4432358A (en) * 1982-01-22 1984-02-21 Fixel Irving E Compression hip screw apparatus
US4573448A (en) * 1983-10-05 1986-03-04 Pilling Co. Method for decompressing herniated intervertebral discs
US4592749A (en) * 1984-06-22 1986-06-03 Gish Biomedical, Inc. Catheter system
US4593685A (en) * 1983-10-17 1986-06-10 Pfizer Hospital Products Group Inc. Bone cement applicator
US4644951A (en) * 1985-09-16 1987-02-24 Concept, Inc. Vacuum sleeve for a surgical appliance
US4653489A (en) * 1984-04-02 1987-03-31 Tronzo Raymond G Fenestrated hip screw and method of augmented fixation
US4832683A (en) * 1985-09-20 1989-05-23 Sumitomo Bakellite Company Limited Surgical instrument
US4909252A (en) * 1988-05-26 1990-03-20 The Regents Of The Univ. Of California Perfusion balloon catheter
US4987892A (en) * 1989-04-04 1991-01-29 Krag Martin H Spinal fixation device
US4990148A (en) * 1989-01-13 1991-02-05 Codman & Shurtleff, Inc. Thin footplate rongeur
US4995868A (en) * 1988-10-12 1991-02-26 Bard Limited Catheter
US5015255A (en) * 1989-05-10 1991-05-14 Spine-Tech, Inc. Spinal stabilization method
US5100423A (en) * 1990-08-21 1992-03-31 Medical Engineering & Development Institute, Inc. Ablation catheter
US5108404A (en) * 1989-02-09 1992-04-28 Arie Scholten Surgical protocol for fixation of bone using inflatable device
US5112346A (en) * 1989-06-08 1992-05-12 Richard Wolf Gmbh Retrograde cutting hook punch
US5190546A (en) * 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
US5197971A (en) * 1990-03-02 1993-03-30 Bonutti Peter M Arthroscopic retractor and method of using the same
US5313962A (en) * 1991-10-18 1994-05-24 Obenchain Theodore G Method of performing laparoscopic lumbar discectomy
US5390683A (en) * 1991-02-22 1995-02-21 Pisharodi; Madhavan Spinal implantation methods utilizing a middle expandable implant
US5397320A (en) * 1994-03-03 1995-03-14 Essig; Mitchell N. Dissecting surgical device and associated method
US5423850A (en) * 1993-10-01 1995-06-13 Berger; J. Lee Balloon compressor for internal fixation of bone fractures
US5480400A (en) * 1993-10-01 1996-01-02 Berger; J. Lee Method and device for internal fixation of bone fractures
US5484441A (en) * 1991-06-17 1996-01-16 Koros; Tibor Rongeur surgical instrument
US5489291A (en) * 1994-02-23 1996-02-06 Wiley; Roy C. Apparatus for removing tissue during surgical procedures
US5496330A (en) * 1993-02-19 1996-03-05 Boston Scientific Corporation Surgical extractor with closely angularly spaced individual filaments
US5499981A (en) * 1993-03-16 1996-03-19 Ep Technologies, Inc. Flexible interlaced multiple electrode assemblies
US5509919A (en) * 1993-09-24 1996-04-23 Young; Merry A. Apparatus for guiding a reaming instrument
US5512037A (en) * 1994-05-12 1996-04-30 United States Surgical Corporation Percutaneous surgical retractor
US5620458A (en) * 1994-03-16 1997-04-15 United States Surgical Corporation Surgical instruments useful for endoscopic spinal procedures
US5632746A (en) * 1989-08-16 1997-05-27 Medtronic, Inc. Device or apparatus for manipulating matter
US5637097A (en) * 1992-04-15 1997-06-10 Yoon; Inbae Penetrating instrument having an expandable anchoring portion
US5707390A (en) * 1990-03-02 1998-01-13 General Surgical Innovations, Inc. Arthroscopic retractors
US5720754A (en) * 1989-08-16 1998-02-24 Medtronic, Inc. Device or apparatus for manipulating matter
US5730704A (en) * 1992-02-24 1998-03-24 Avitall; Boaz Loop electrode array mapping and ablation catheter for cardiac chambers
US5749879A (en) * 1989-08-16 1998-05-12 Medtronic, Inc. Device or apparatus for manipulating matter
US5752969A (en) * 1993-06-17 1998-05-19 Sofamor S.N.C. Instrument for the surgical treatment of an intervertebral disc by the anterior route
US5865802A (en) * 1988-07-22 1999-02-02 Yoon; Inbae Expandable multifunctional instruments for creating spaces at obstructed sites endoscopically
US5876399A (en) * 1997-05-28 1999-03-02 Irvine Biomedical, Inc. Catheter system and methods thereof
US5876369A (en) * 1995-01-23 1999-03-02 Advanced Catheter Engineering Tissue removing catheter and RF cutting method
US5879353A (en) * 1995-01-17 1999-03-09 Gore Enterprise Holdings, Inc. Guided bone rasp
US5882340A (en) * 1992-04-15 1999-03-16 Yoon; Inbae Penetrating instrument having an expandable anchoring portion for triggering protrusion of a safety member and/or retraction of a penetrating member
US5891147A (en) * 1996-06-25 1999-04-06 Sdgi Holdings, Inc. Minimally invasive spinal surgical methods & instruments
US6015406A (en) * 1996-01-09 2000-01-18 Gyrus Medical Limited Electrosurgical instrument
US6039761A (en) * 1997-02-12 2000-03-21 Li Medical Technologies, Inc. Intervertebral spacer and tool and method for emplacement thereof
US6066154A (en) * 1994-01-26 2000-05-23 Kyphon Inc. Inflatable device for use in surgical protocol relating to fixation of bone
US6187015B1 (en) * 1997-05-02 2001-02-13 Micro Therapeutics, Inc. Expandable stent apparatus and method
US6190381B1 (en) * 1995-06-07 2001-02-20 Arthrocare Corporation Methods for tissue resection, ablation and aspiration
US6200320B1 (en) * 1989-04-24 2001-03-13 Gary Karlin Michelson Surgical rongeur
US6214016B1 (en) * 1999-04-29 2001-04-10 Medtronic, Inc. Medical instrument positioning device internal to a catheter or lead and method of use
US6224604B1 (en) * 1999-07-30 2001-05-01 Loubert Suddaby Expandable orthopedic drill for vertebral interbody fusion techniques
US6228022B1 (en) * 1998-10-28 2001-05-08 Sdgi Holdings, Inc. Methods and instruments for spinal surgery
US6228068B1 (en) * 1996-05-22 2001-05-08 Inbae Yoon Expandable endoscopic portal and methods therefor
US6228082B1 (en) * 1995-11-22 2001-05-08 Arthrocare Corporation Systems and methods for electrosurgical treatment of vascular disorders
US20020010471A1 (en) * 2000-02-04 2002-01-24 Wironen John F. Methods for injecting materials into bone
US20020013600A1 (en) * 1997-08-15 2002-01-31 Kyphon Inc. Expandable, asymmetric structures for deployment in interior body regions
US20020022856A1 (en) * 2000-08-14 2002-02-21 Wesley Johnson Transverse cavity device and method
US20020026195A1 (en) * 2000-04-07 2002-02-28 Kyphon Inc. Insertion devices and method of use
US20020026197A1 (en) * 2000-08-11 2002-02-28 Foley Kevin T. Surgical instrumentation and method for treatment of the spine
US6383188B2 (en) * 2000-02-15 2002-05-07 The Spineology Group Llc Expandable reamer
US6395007B1 (en) * 1999-03-16 2002-05-28 American Osteomedix, Inc. Apparatus and method for fixation of osteoporotic bone
US20030004530A1 (en) * 1998-01-27 2003-01-02 Kyphon Inc. Slip-fit handle for hand-held instruments that access interior body regions
US20030032963A1 (en) * 2001-10-24 2003-02-13 Kyphon Inc. Devices and methods using an expandable body with internal restraint for compressing cancellous bone
US6530933B1 (en) * 1998-12-31 2003-03-11 Teresa T. Yeung Methods and devices for fastening bulging or herniated intervertebral discs
US20030078589A1 (en) * 1998-04-01 2003-04-24 Preissman Howard E. High pressure applicator
US20040002713A1 (en) * 2002-06-26 2004-01-01 Olson Stanley W. Retrograde plunger delivery system
US6679886B2 (en) * 2000-09-01 2004-01-20 Synthes (Usa) Tools and methods for creating cavities in bone
US6682535B2 (en) * 1999-06-16 2004-01-27 Thomas Hoogland Apparatus for decompressing herniated intervertebral discs
US20040024410A1 (en) * 2002-08-02 2004-02-05 Scimed Life Systems, Inc. Media delivery device for bone structures
US20040052829A1 (en) * 2000-10-24 2004-03-18 Shimp Lawrence A. Vertebral augmentation composition and method
US20040064058A1 (en) * 2001-10-24 2004-04-01 Mckay William F. Methods and instruments for treating pseudoarthrosis
US6716216B1 (en) * 1998-08-14 2004-04-06 Kyphon Inc. Systems and methods for treating vertebral bodies
US20040068264A1 (en) * 2002-10-03 2004-04-08 Treace John T. Bendable needle for delivering bone graft material and method of use
US20040068267A1 (en) * 2000-06-27 2004-04-08 Fraser Harvie Surgical procedures and instruments
US6719761B1 (en) * 1997-08-13 2004-04-13 Kyphon Inc. System and methods for injecting flowable materials into bones
US6719773B1 (en) * 1998-06-01 2004-04-13 Kyphon Inc. Expandable structures for deployment in interior body regions
US6726691B2 (en) * 1998-08-14 2004-04-27 Kyphon Inc. Methods for treating fractured and/or diseased bone
US20040092946A1 (en) * 2001-02-20 2004-05-13 Bagga Charanpreet S. System and kit for delivery of restorative materials
US20040102845A1 (en) * 2002-11-21 2004-05-27 Reynolds Martin A. Methods of performing embolism-free vertebroplasty and devices therefor
US6863672B2 (en) * 1998-04-06 2005-03-08 Kyphon Inc. Structures and methods for creating cavities in interior body regions
US6875219B2 (en) * 2003-02-14 2005-04-05 Yves P. Arramon Bone access system
US7044954B2 (en) * 1994-01-26 2006-05-16 Kyphon Inc. Method for treating a vertebral body

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US582732A (en) * 1897-05-18 Logging apparatus
US1366877A (en) * 1920-11-17 1921-01-25 Joseph E Craig Guide and gage for dental drills
US2526662A (en) 1946-12-10 1950-10-24 Herbert E Hipps Bone meal extractor
US2610626A (en) 1951-07-27 1952-09-16 John D Edwards Syringe
US3045677A (en) 1960-05-03 1962-07-24 American Cystoscope Makers Inc Inflatable balloon catheter
US3626949A (en) 1969-01-23 1971-12-14 Wallace B Shute Cervical dilator
US3945375A (en) * 1972-04-04 1976-03-23 Surgical Design Corporation Rotatable surgical instrument
US3848601A (en) * 1972-06-14 1974-11-19 G Ma Method for interbody fusion of the spine
US3800788A (en) * 1972-07-12 1974-04-02 N White Antral catheter for reduction of fractures
US3949479A (en) * 1972-11-13 1976-04-13 Oscar Malmin Endodontic operating and sealing method and apparatus therefor
US3828790A (en) 1973-02-28 1974-08-13 American Cystoscope Makers Inc Surgical snare
US4059115A (en) * 1976-06-14 1977-11-22 Georgy Stepanovich Jumashev Surgical instrument for operation of anterior fenestrated spondylodessis in vertebral osteochondrosis
US4083369A (en) * 1976-07-02 1978-04-11 Manfred Sinnreich Surgical instruments
US4299237A (en) 1978-07-21 1981-11-10 Foti Thomas M Closed flow caloric test device
US4341206A (en) 1978-12-19 1982-07-27 Synthes Ag Device for producing a hole in a bone
DE2914455A1 (en) 1979-04-10 1980-10-23 Maschf Augsburg Nuernberg Ag An apparatus for manufacturing a cavity in a bone
US4265231A (en) * 1979-04-30 1981-05-05 Scheller Jr Arnold D Curved drill attachment for bone drilling uses
US4457710A (en) 1979-08-03 1984-07-03 Inventive Technology International Dental instrument
US4327736A (en) * 1979-11-20 1982-05-04 Kanji Inoue Balloon catheter
US4293962A (en) * 1980-02-14 1981-10-13 Zimmer Usa, Inc. Bone plug inserting system
US4357716A (en) * 1980-07-09 1982-11-09 Brown Byron L Device and method for cementing a hip prosthesis in a femoral canal
US4399814A (en) * 1981-04-27 1983-08-23 Massachusetts Institute Of Technology Method and apparatus for pressure-coated bones
US4488549A (en) * 1981-08-25 1984-12-18 University Of Exeter Pressurization of cement in bones
US4462394A (en) 1982-05-03 1984-07-31 Howmedica, Inc. Intramedullary canal seal for cement pressurization
US4554914A (en) * 1983-10-04 1985-11-26 Kapp John P Prosthetic vertebral body
US4601290A (en) * 1983-10-11 1986-07-22 Cabot Medical Corporation Surgical instrument for cutting body tissue from a body area having a restricted space
DE3484395D1 (en) * 1983-12-08 1991-05-08 Cedars Sinai Medical Center Laser for medical treatment of diseased areas of organic tissue.
GB8501907D0 (en) 1985-01-25 1985-02-27 Thackray C F Ltd Surgical instruments
US4622012A (en) 1985-03-27 1986-11-11 Smoler Lewis S Dental post system
DE3536516C2 (en) 1985-10-12 1989-11-30 Christian Dr.Med. 6500 Mainz De Milewski
US4888024A (en) * 1985-11-08 1989-12-19 Powlan Roy Y Prosthetic device and method of fixation within the medullary cavity of bones
US4646738A (en) * 1985-12-05 1987-03-03 Concept, Inc. Rotary surgical tool
US4650489A (en) * 1986-01-30 1987-03-17 Massachusetts Institute Of Technology Prosthetic device for implantation in bone
US4723545A (en) * 1986-02-03 1988-02-09 Graduate Hospital Foundation Research Corporation Power assisted arthroscopic surgical device
DE3630069C1 (en) 1986-09-04 1988-01-28 Aesculap Werke Ag Surgical instrument for compacting spongy substance
US4790312A (en) 1987-01-20 1988-12-13 Becton Dickinson Acutecare, Inc. Surgical knife
DE3800482A1 (en) 1988-01-11 1989-07-20 List Heinz Juergen Surgical drilling instrument
US4944678A (en) 1988-02-08 1990-07-31 Bristol-Myers-Squibb Company Process and apparatus for devitalization of a tooth
DE69433702T2 (en) * 1993-06-10 2005-03-31 Karlin Technology, Inc., Saugus Protection device with two bushings for surgery of the intervertebral space
US5090957A (en) * 1988-10-05 1992-02-25 Abiomed, Inc. Intraaortic balloon insertion
US5156606A (en) * 1988-10-11 1992-10-20 Zimmer, Inc. Method and apparatus for removing pre-placed prosthetic joints and preparing for their replacement
US5147377A (en) 1988-11-23 1992-09-15 Harvinder Sahota Balloon catheters
US5090958A (en) * 1988-11-23 1992-02-25 Harvinder Sahota Balloon catheters
US5019042A (en) * 1988-11-23 1991-05-28 Harvinder Sahota Balloon catheters
US5160321A (en) 1988-11-23 1992-11-03 Harvinder Sahota Balloon catheters
US4983183A (en) * 1989-02-06 1991-01-08 Horowitz Stephen M Hip prosthesis and method for implanting the same
US5027792A (en) * 1989-03-17 1991-07-02 Percutaneous Technologies, Inc. Endoscopic revision hip surgery device
DE3909843C2 (en) * 1989-03-25 1992-12-17 Gsf - Forschungszentrum Fuer Umwelt Und Gesundheit, Gmbh, 8000 Muenchen, De
CA2007210C (en) * 1989-05-10 1996-07-09 Stephen D. Kuslich Intervertebral reamer
DE3922044C2 (en) 1989-07-05 1991-05-29 Matthias Dr. 8000 Muenchen De Richter-Turtur
US4986830A (en) * 1989-09-22 1991-01-22 Schneider (U.S.A.) Inc. Valvuloplasty catheter with balloon which remains stable during inflation
US5059193A (en) * 1989-11-20 1991-10-22 Spine-Tech, Inc. Expandable spinal implant and surgical method
DE4001833C2 (en) 1990-01-23 1992-02-27 Juergen Dr. 6943 Birkenau De Fischer
US5152744A (en) 1990-02-07 1992-10-06 Smith & Nephew Dyonics Surgical instrument
US5290294A (en) * 1990-04-17 1994-03-01 Brian Cox Method and apparatus for removal of a foreign body cavity
EP0482195B1 (en) * 1990-05-17 1996-01-10 Sumitomo Bakelite Company Limited Surgical instrument
US5083923A (en) * 1990-06-04 1992-01-28 Mcspadden John T Method of obturating an extirpated root canal
US5035617A (en) 1990-06-05 1991-07-30 Mcspadden John T Endodontic instrument
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US5047035A (en) * 1990-08-10 1991-09-10 Mikhail Michael W E System for performing hip prosthesis revision surgery
US5064428A (en) * 1990-09-18 1991-11-12 Cook Incorporated Medical retrieval basket
DE69129487T2 (en) 1990-10-19 1999-01-07 Smith & Nephew Inc A surgical device
US5254091A (en) * 1991-01-08 1993-10-19 Applied Medical Resources Corporation Low profile balloon catheter and method for making same
US5269783A (en) * 1991-05-13 1993-12-14 United States Surgical Corporation Device and method for repairing torn tissue
US5242461A (en) * 1991-07-22 1993-09-07 Dow Corning Wright Variable diameter rotating recanalization catheter and surgical method
US5226888A (en) 1991-10-25 1993-07-13 Michelle Arney Coiled, perfusion balloon catheter
US5302129A (en) * 1991-11-19 1994-04-12 Heath Derek E Endodontic procedure and instrument
DE4140402A1 (en) 1991-12-07 1993-06-09 Dieter Prof. Dr.Med. 7700 Singen De Ruehland Instrument for surgical intervention in stomach cavity - has sleeve tube for at least one axially movable rod with blade at operation end of instrument being controlled by rod
US5387215A (en) 1992-02-12 1995-02-07 Sierra Surgical Inc. Surgical instrument for cutting hard tissue and method of use
US5385566A (en) * 1992-02-20 1995-01-31 Ullmark; Goesta Device and a method for use in transplantation of bone tissue material
US5295959A (en) * 1992-03-13 1994-03-22 Medtronic, Inc. Autoperfusion dilatation catheter having a bonded channel
US5295995A (en) * 1992-08-27 1994-03-22 Kleiman Jay H Perfusion dilatation catheter
US5284443A (en) * 1992-08-28 1994-02-08 Coltene/Whaledent, Inc. Method of forming dental restorations
US5411514A (en) * 1992-09-30 1995-05-02 Linvatec Corporation Bendable variable angle rotating shaver
US5385570A (en) * 1993-01-12 1995-01-31 R. J. Surgical Instruments, Inc. Surgical cutting instrument
US5628747A (en) * 1993-01-22 1997-05-13 Wright Medical Technology, Inc. Device for removing cancellous bone
EP0683651B1 (en) * 1993-02-10 1999-09-29 Sulzer Spine-Tech Inc. Spinal stabilization surgical tool set
US5423823A (en) 1993-02-18 1995-06-13 Arthrex Inc. Coring reamer
US5439464A (en) * 1993-03-09 1995-08-08 Shapiro Partners Limited Method and instruments for performing arthroscopic spinal surgery
US5352199A (en) 1993-05-28 1994-10-04 Numed, Inc. Balloon catheter
US5437665A (en) * 1993-10-12 1995-08-01 Munro; Malcolm G. Electrosurgical loop electrode instrument for laparoscopic surgery
US5536267A (en) 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
WO1995014433A1 (en) * 1993-11-24 1995-06-01 Orthopaedic Innovations, Inc. Cannulated instrumentation for total joint arthroplasty and method of use
US5499961A (en) * 1993-12-17 1996-03-19 Mattox; Ernest M. Kneeling-prone-kneeling exercise device
US5484411A (en) 1994-01-14 1996-01-16 Cordis Corporation Spiral shaped perfusion balloon and method of use and manufacture
US6248110B1 (en) 1994-01-26 2001-06-19 Kyphon, Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
US5387193A (en) * 1994-02-09 1995-02-07 Baxter International Inc. Balloon dilation catheter with hypotube
US5527316A (en) * 1994-02-23 1996-06-18 Stone; Kevin T. Surgical reamer
US5470313A (en) 1994-02-24 1995-11-28 Cardiovascular Dynamics, Inc. Variable diameter balloon dilatation catheter
FR2723836B1 (en) * 1994-08-24 1996-12-20 Rech Ligamentaire Scrl Soc Civ Rape for boring, cleaning and deburring of a bone tunnel
US5591170A (en) * 1994-10-14 1997-01-07 Genesis Orthopedics Intramedullary bone cutting saw
US5571098A (en) 1994-11-01 1996-11-05 The General Hospital Corporation Laser surgical devices
US5643305A (en) 1994-11-18 1997-07-01 Al-Tameem; Moshin Device for excision of a fistula
US5836957A (en) 1994-12-22 1998-11-17 Devices For Vascular Intervention, Inc. Large volume atherectomy device
US5611803A (en) * 1994-12-22 1997-03-18 Urohealth Systems, Inc. Tissue segmentation device
US5814044A (en) * 1995-02-10 1998-09-29 Enable Medical Corporation Apparatus and method for morselating and removing tissue from a patient
US5624447A (en) * 1995-03-20 1997-04-29 Othy, Inc. Surgical tool guide and entry hole positioner
US5674235A (en) * 1995-05-10 1997-10-07 Ultralase Technologies International Ultrasonic surgical cutting instrument
US5658280A (en) * 1995-05-22 1997-08-19 Issa; Muta M. Resectoscope electrode assembly with simultaneous cutting and coagulation
US5827312A (en) * 1995-06-09 1998-10-27 Instratek Incorporated Marked cannula
US5695513A (en) * 1996-03-01 1997-12-09 Metagen, Llc Flexible cutting tool and methods for its use
US5925039A (en) * 1996-06-12 1999-07-20 Iti Medical Technologies, Inc. Electrosurgical instrument with conductive ceramic or cermet and method of making same
US5984932A (en) * 1996-11-27 1999-11-16 Yoon; Inbae Suturing instrument with one or more spreadable needle holders mounted for arcuate movement
DE69734473T2 (en) * 1996-12-13 2006-07-20 Norian Corp., Cupertino for storing devices and mix of cements
US5984937A (en) * 1997-03-31 1999-11-16 Origin Medsystems, Inc. Orbital dissection cannula and method
US5928239A (en) * 1998-03-16 1999-07-27 University Of Washington Percutaneous surgical cavitation device and method
JP3101733B2 (en) * 1998-05-29 2000-10-23 華邦電子股▲ふん▼有限公司 Removal method and apparatus of mobile ions in the wafer
US6241734B1 (en) * 1998-08-14 2001-06-05 Kyphon, Inc. Systems and methods for placing materials into bone
US6364565B1 (en) * 2000-02-01 2002-04-02 Caterpillar Inc. Piston pin assembly

Patent Citations (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US383639A (en) * 1888-05-29 Manure-distributer
US817973A (en) * 1904-06-06 1906-04-17 Caspar Friedrich Hausmann Uterine dilator.
US3181533A (en) * 1962-01-15 1965-05-04 William C Heath Surgical snare
US3640280A (en) * 1969-11-26 1972-02-08 Daniel R Slanker Power-driven reciprocating bone surgery instrument
US4024639A (en) * 1975-02-25 1977-05-24 End-Dent, Inc. Bone implants and method for inserting the same
US4203444A (en) * 1977-11-07 1980-05-20 Dyonics, Inc. Surgical instrument suitable for closed surgery such as of the knee
US4203444B1 (en) * 1977-11-07 1987-07-21
US4204531A (en) * 1977-12-28 1980-05-27 Yacov Aginsky Intramedullary nail with expanding mechanism
US4245359A (en) * 1978-03-28 1981-01-20 Sulzer Brothers Limited Plug for openings produced by operative procedures in medullated bones
US4323071A (en) * 1978-04-24 1982-04-06 Advanced Catheter Systems, Inc. Vascular guiding catheter assembly and vascular dilating catheter assembly and a combination thereof and methods of making the same
US4323071B1 (en) * 1978-04-24 1990-05-29 Advanced Cardiovascular System
US4274163A (en) * 1979-07-16 1981-06-23 The Regents Of The University Of California Prosthetic fixation technique
US4369772A (en) * 1980-04-28 1983-01-25 University Of Florida Method for strengthening a fractured bone
US4313434A (en) * 1980-10-17 1982-02-02 David Segal Fracture fixation
US4432358A (en) * 1982-01-22 1984-02-21 Fixel Irving E Compression hip screw apparatus
US4573448A (en) * 1983-10-05 1986-03-04 Pilling Co. Method for decompressing herniated intervertebral discs
US5190546A (en) * 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
US4593685A (en) * 1983-10-17 1986-06-10 Pfizer Hospital Products Group Inc. Bone cement applicator
US4653489A (en) * 1984-04-02 1987-03-31 Tronzo Raymond G Fenestrated hip screw and method of augmented fixation
US4592749A (en) * 1984-06-22 1986-06-03 Gish Biomedical, Inc. Catheter system
US4644951A (en) * 1985-09-16 1987-02-24 Concept, Inc. Vacuum sleeve for a surgical appliance
US4832683A (en) * 1985-09-20 1989-05-23 Sumitomo Bakellite Company Limited Surgical instrument
US4909252A (en) * 1988-05-26 1990-03-20 The Regents Of The Univ. Of California Perfusion balloon catheter
US5865802A (en) * 1988-07-22 1999-02-02 Yoon; Inbae Expandable multifunctional instruments for creating spaces at obstructed sites endoscopically
US4995868A (en) * 1988-10-12 1991-02-26 Bard Limited Catheter
US4990148A (en) * 1989-01-13 1991-02-05 Codman & Shurtleff, Inc. Thin footplate rongeur
US5108404A (en) * 1989-02-09 1992-04-28 Arie Scholten Surgical protocol for fixation of bone using inflatable device
US4987892A (en) * 1989-04-04 1991-01-29 Krag Martin H Spinal fixation device
US6200320B1 (en) * 1989-04-24 2001-03-13 Gary Karlin Michelson Surgical rongeur
US5015255A (en) * 1989-05-10 1991-05-14 Spine-Tech, Inc. Spinal stabilization method
US5112346A (en) * 1989-06-08 1992-05-12 Richard Wolf Gmbh Retrograde cutting hook punch
US5749879A (en) * 1989-08-16 1998-05-12 Medtronic, Inc. Device or apparatus for manipulating matter
US5720754A (en) * 1989-08-16 1998-02-24 Medtronic, Inc. Device or apparatus for manipulating matter
US5632746A (en) * 1989-08-16 1997-05-27 Medtronic, Inc. Device or apparatus for manipulating matter
US5707390A (en) * 1990-03-02 1998-01-13 General Surgical Innovations, Inc. Arthroscopic retractors
US5197971A (en) * 1990-03-02 1993-03-30 Bonutti Peter M Arthroscopic retractor and method of using the same
US5100423A (en) * 1990-08-21 1992-03-31 Medical Engineering & Development Institute, Inc. Ablation catheter
US5390683A (en) * 1991-02-22 1995-02-21 Pisharodi; Madhavan Spinal implantation methods utilizing a middle expandable implant
US5484441A (en) * 1991-06-17 1996-01-16 Koros; Tibor Rongeur surgical instrument
US5313962A (en) * 1991-10-18 1994-05-24 Obenchain Theodore G Method of performing laparoscopic lumbar discectomy
US5730704A (en) * 1992-02-24 1998-03-24 Avitall; Boaz Loop electrode array mapping and ablation catheter for cardiac chambers
US5882340A (en) * 1992-04-15 1999-03-16 Yoon; Inbae Penetrating instrument having an expandable anchoring portion for triggering protrusion of a safety member and/or retraction of a penetrating member
US5637097A (en) * 1992-04-15 1997-06-10 Yoon; Inbae Penetrating instrument having an expandable anchoring portion
US5496330A (en) * 1993-02-19 1996-03-05 Boston Scientific Corporation Surgical extractor with closely angularly spaced individual filaments
US5499981A (en) * 1993-03-16 1996-03-19 Ep Technologies, Inc. Flexible interlaced multiple electrode assemblies
US5752969A (en) * 1993-06-17 1998-05-19 Sofamor S.N.C. Instrument for the surgical treatment of an intervertebral disc by the anterior route
US5509919A (en) * 1993-09-24 1996-04-23 Young; Merry A. Apparatus for guiding a reaming instrument
US5480400A (en) * 1993-10-01 1996-01-02 Berger; J. Lee Method and device for internal fixation of bone fractures
US5423850A (en) * 1993-10-01 1995-06-13 Berger; J. Lee Balloon compressor for internal fixation of bone fractures
US7044954B2 (en) * 1994-01-26 2006-05-16 Kyphon Inc. Method for treating a vertebral body
US6066154A (en) * 1994-01-26 2000-05-23 Kyphon Inc. Inflatable device for use in surgical protocol relating to fixation of bone
US6235043B1 (en) * 1994-01-26 2001-05-22 Kyphon, Inc. Inflatable device for use in surgical protocol relating to fixation of bone
US6981981B2 (en) * 1994-01-26 2006-01-03 Kyphon Inc. Inflatable device for use in surgical protocol relating to fixation of bone
US5489291A (en) * 1994-02-23 1996-02-06 Wiley; Roy C. Apparatus for removing tissue during surgical procedures
US5397320A (en) * 1994-03-03 1995-03-14 Essig; Mitchell N. Dissecting surgical device and associated method
US5755732A (en) * 1994-03-16 1998-05-26 United States Surgical Corporation Surgical instruments useful for endoscopic spinal procedures
US5620458A (en) * 1994-03-16 1997-04-15 United States Surgical Corporation Surgical instruments useful for endoscopic spinal procedures
US5512037A (en) * 1994-05-12 1996-04-30 United States Surgical Corporation Percutaneous surgical retractor
US5879353A (en) * 1995-01-17 1999-03-09 Gore Enterprise Holdings, Inc. Guided bone rasp
US5876369A (en) * 1995-01-23 1999-03-02 Advanced Catheter Engineering Tissue removing catheter and RF cutting method
US6190381B1 (en) * 1995-06-07 2001-02-20 Arthrocare Corporation Methods for tissue resection, ablation and aspiration
US6228082B1 (en) * 1995-11-22 2001-05-08 Arthrocare Corporation Systems and methods for electrosurgical treatment of vascular disorders
US6015406A (en) * 1996-01-09 2000-01-18 Gyrus Medical Limited Electrosurgical instrument
US6228068B1 (en) * 1996-05-22 2001-05-08 Inbae Yoon Expandable endoscopic portal and methods therefor
US5891147A (en) * 1996-06-25 1999-04-06 Sdgi Holdings, Inc. Minimally invasive spinal surgical methods & instruments
US6039761A (en) * 1997-02-12 2000-03-21 Li Medical Technologies, Inc. Intervertebral spacer and tool and method for emplacement thereof
US6187015B1 (en) * 1997-05-02 2001-02-13 Micro Therapeutics, Inc. Expandable stent apparatus and method
US5876399A (en) * 1997-05-28 1999-03-02 Irvine Biomedical, Inc. Catheter system and methods thereof
US6719761B1 (en) * 1997-08-13 2004-04-13 Kyphon Inc. System and methods for injecting flowable materials into bones
US20020013600A1 (en) * 1997-08-15 2002-01-31 Kyphon Inc. Expandable, asymmetric structures for deployment in interior body regions
US20030004530A1 (en) * 1998-01-27 2003-01-02 Kyphon Inc. Slip-fit handle for hand-held instruments that access interior body regions
US20030078589A1 (en) * 1998-04-01 2003-04-24 Preissman Howard E. High pressure applicator
US6863672B2 (en) * 1998-04-06 2005-03-08 Kyphon Inc. Structures and methods for creating cavities in interior body regions
US6719773B1 (en) * 1998-06-01 2004-04-13 Kyphon Inc. Expandable structures for deployment in interior body regions
US6716216B1 (en) * 1998-08-14 2004-04-06 Kyphon Inc. Systems and methods for treating vertebral bodies
US6726691B2 (en) * 1998-08-14 2004-04-27 Kyphon Inc. Methods for treating fractured and/or diseased bone
US6228022B1 (en) * 1998-10-28 2001-05-08 Sdgi Holdings, Inc. Methods and instruments for spinal surgery
US6530933B1 (en) * 1998-12-31 2003-03-11 Teresa T. Yeung Methods and devices for fastening bulging or herniated intervertebral discs
US20030036763A1 (en) * 1999-03-16 2003-02-20 Mohit Bhatnagar Apparatus and method for fixation of osteoporotic bone
US6395007B1 (en) * 1999-03-16 2002-05-28 American Osteomedix, Inc. Apparatus and method for fixation of osteoporotic bone
US6214016B1 (en) * 1999-04-29 2001-04-10 Medtronic, Inc. Medical instrument positioning device internal to a catheter or lead and method of use
US6682535B2 (en) * 1999-06-16 2004-01-27 Thomas Hoogland Apparatus for decompressing herniated intervertebral discs
US6224604B1 (en) * 1999-07-30 2001-05-01 Loubert Suddaby Expandable orthopedic drill for vertebral interbody fusion techniques
US20020010471A1 (en) * 2000-02-04 2002-01-24 Wironen John F. Methods for injecting materials into bone
US6383188B2 (en) * 2000-02-15 2002-05-07 The Spineology Group Llc Expandable reamer
US20020026195A1 (en) * 2000-04-07 2002-02-28 Kyphon Inc. Insertion devices and method of use
US20040068267A1 (en) * 2000-06-27 2004-04-08 Fraser Harvie Surgical procedures and instruments
US20020026197A1 (en) * 2000-08-11 2002-02-28 Foley Kevin T. Surgical instrumentation and method for treatment of the spine
US6676665B2 (en) * 2000-08-11 2004-01-13 Sdgi Holdings, Inc. Surgical instrumentation and method for treatment of the spine
US20020022856A1 (en) * 2000-08-14 2002-02-21 Wesley Johnson Transverse cavity device and method
US6679886B2 (en) * 2000-09-01 2004-01-20 Synthes (Usa) Tools and methods for creating cavities in bone
US20040052829A1 (en) * 2000-10-24 2004-03-18 Shimp Lawrence A. Vertebral augmentation composition and method
US20040092946A1 (en) * 2001-02-20 2004-05-13 Bagga Charanpreet S. System and kit for delivery of restorative materials
US20030032963A1 (en) * 2001-10-24 2003-02-13 Kyphon Inc. Devices and methods using an expandable body with internal restraint for compressing cancellous bone
US20040064058A1 (en) * 2001-10-24 2004-04-01 Mckay William F. Methods and instruments for treating pseudoarthrosis
US20040002713A1 (en) * 2002-06-26 2004-01-01 Olson Stanley W. Retrograde plunger delivery system
US6730095B2 (en) * 2002-06-26 2004-05-04 Scimed Life Systems, Inc. Retrograde plunger delivery system
US20040024410A1 (en) * 2002-08-02 2004-02-05 Scimed Life Systems, Inc. Media delivery device for bone structures
US20040068264A1 (en) * 2002-10-03 2004-04-08 Treace John T. Bendable needle for delivering bone graft material and method of use
US20040102845A1 (en) * 2002-11-21 2004-05-27 Reynolds Martin A. Methods of performing embolism-free vertebroplasty and devices therefor
US6875219B2 (en) * 2003-02-14 2005-04-05 Yves P. Arramon Bone access system

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US20060184192A1 (en) * 2005-02-11 2006-08-17 Markworth Aaron D Systems and methods for providing cavities in interior body regions
US9089347B2 (en) 2006-07-07 2015-07-28 Orthophoenix, Llc Medical device with dual expansion mechanism
US20080009875A1 (en) * 2006-07-07 2008-01-10 Meera Sankaran Medical device with dual expansion mechanism
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US20080009876A1 (en) * 2006-07-07 2008-01-10 Meera Sankaran Medical device with expansion mechanism
US7909873B2 (en) 2006-12-15 2011-03-22 Soteira, Inc. Delivery apparatus and methods for vertebrostenting
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US20100030216A1 (en) * 2008-07-30 2010-02-04 Arcenio Gregory B Discectomy tool having counter-rotating nucleus disruptors
US20100160921A1 (en) * 2008-12-19 2010-06-24 Arthrocare Corporation Cancellous bone displacement system and methods of use
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US9220554B2 (en) 2010-02-18 2015-12-29 Globus Medical, Inc. Methods and apparatus for treating vertebral fractures

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EP1073371A1 (en) 2001-02-07 application

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