US20070021733A1 - Internal fluid connector - Google Patents

Internal fluid connector Download PDF

Info

Publication number
US20070021733A1
US20070021733A1 US11407647 US40764706A US2007021733A1 US 20070021733 A1 US20070021733 A1 US 20070021733A1 US 11407647 US11407647 US 11407647 US 40764706 A US40764706 A US 40764706A US 2007021733 A1 US2007021733 A1 US 2007021733A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
unit
reservoir
needle
device
pump
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11407647
Inventor
Steffen Hansen
Bjorn Larsen
Claus Moller
Ole Nielsen
Jim Radmer
Jan Preuthun
Philip Sparholt
Erik Ethelfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14506Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons mechanically driven, e.g. spring or clockwork
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1585Needle inserters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14212Pumping with an aspiration and an expulsion action
    • A61M5/14216Reciprocating piston type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14212Pumping with an aspiration and an expulsion action
    • A61M5/14224Diaphragm type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/1483Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure
    • A61M5/1486Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure the bags being substantially completely surrounded by fluid

Abstract

A medical device is provided comprising a reservoir adapted to contain a fluid drug in an interior thereof, and a pump assembly. The pump assembly comprises a pump inlet, a pump outlet and an internal flow path arranged there between, and a fluid connector having an inlet and an outlet. The fluid connector is arranged to be operated from an initial state in which the fluid connector is arranged within the interior of the pump and an actuated state in which fluid communication is established between the interior of the reservoir and the interior of the pump assembly via the fluid connector and with the outlet of the fluid connector being arranged in the flow path of the pump assembly.

Description

    CROSS REFERENCE TO RELATED APPLICATIONS
  • [0001]
    This Application is a continuation of International Application serial no. PCT/DK2004/000727 filed Oct. 21, 2004 and claims priority from Danish Application serial nos. PA 2003 01545 filed Oct. 21, 2003, PA 2003 01590 filed Oct. 28, 2003; European application serial nos. EP 03024276.2 filed Oct. 23, 2003, EP 03024626.8 filed Oct. 27, 2003 and to U.S. Provisional Application Ser. Nos. 60/518,881 filed Nov. 10, 2003, 60/518,832 filed Nov. 10, 2003 and 60/518,836 filed Nov. 10, 2003.
  • FIELD OF THE INVENTION
  • [0002]
    The present invention generally relates to a medical device comprising a pump assembly and a reservoir adapted to be connected in fluid communication with each other.
  • BACKGROUND OF THE INVENTION
  • [0003]
    In the disclosure of the present invention reference is mostly made to the treatment of diabetes by injection or infusion of insulin, however, this is only an exemplary use of the present invention.
  • [0004]
    Portable drug delivery devices for delivering a drug to a patient are well known and generally comprise a reservoir adapted to contain a liquid drug and having an outlet in fluid communication with a hollow infusion needle, as well as expelling means for expelling a drug out of the reservoir and through the skin of the subject via the hollow needle. Such devices are often termed infusion pumps.
  • [0005]
    Basically, infusion pumps can be divided into two classes. The first class comprises infusion pumps which are relatively expensive pumps intended for 34 years use, for which reason the initial cost for such a pump often is a barrier to this type of therapy. Although more complex than traditional syringes and pens, the pump offer the advantages of continuous infusion of insulin, precision in dosing and optionally programmable delivery profiles and user actuated bolus infusions in connections with meals.
  • [0006]
    Addressing the above problem, several attempts have been made to provide a second class of drug infusion devices that are low in cost and convenient to use. Some of these devices are intended to be partially or entirely disposable and may provide many of the advantages associated with an infusion pump without the attendant cost and inconveniencies, e.g. the pump may be prefilled thus avoiding the need for filling or refilling a drug reservoir. Examples of this type of infusion devices are known from U.S. Pat. Nos. 4,340,048 and 4,552,561 (based on osmotic pumps), U.S. Pat. No. 5,858,001 (based on a piston pump), U.S. Pat. No. 6,280,148 (based on a membrane pump), U.S. Pat. No. 5,957,895 (based on a flow restrictor pump (also know as a bleeding hole pump)), U.S. Pat. No. 5,527,288 (based on a gas generating pump), or U.S. Pat. No. 5,814,020 (based on a swellable gel) which all in the last decades have been proposed for use in inexpensive, primarily disposable drug infusion devices, the cited documents being incorporated by reference. U.S. Pat. No. 6,364,865 discloses a manually held infusion device allowing two vial-type containers to be connected and a pressure to be build up in one of the containers to thereby expel a drug contained in that container.
  • [0007]
    The disposable pumps generally comprises a skin-contacting mounting surface adapted for application to the skin of a subject by adhesive means, and with the infusion needle arranged such that in a situation of use it projects from the mounting surface to thereby penetrate the skin of the subject, whereby the place where the needle penetrates the skin is covered while the appliance is in use. The infusion needle may be arranged to permanently project from the mounting surface such that the needle is inserted simultaneously with the application of the infusion pump, this as disclosed in U.S. Pat. Nos. 2,605,765, 4,340,048 and in EP 1 177 802, or the needle may be supplied with the device in a retracted state, i.e. with the distal pointed end of the needle “hidden” inside the pump device, this allowing the user to place the pump device on the skin without the possibility of observing the needle, this as disclosed in U.S. Pat. Nos. 5,858,001 and 5,814,020. In addition to pumps, alternative means for transporting a fluid drug may be used, e.g. iontophoresis as discussed below.
  • [0008]
    Although it can be expected that the above described second class of fully or partly disposable infusion devices can be manufactured considerably cheaper than the traditional durable infusion pump, they are still believed to be too expensive to be used as a real alternative to traditional infusion pumps for use on an every-day basis.
  • DISCLOSURE OF THE INVENTION
  • [0009]
    Having regard to the above-identified problems, it is an object of the present invention to provide a skin mountable drug delivery device or system as well as components therefore, which allow such a device or system to be used in a convenient and cost-effective manner. The configuration of the system and the components therefore should contribute in providing a medical delivery means which allows for easy and swift operation yet being reliable in use.
  • [0010]
    In the disclosure of the present invention, embodiments and aspects will be described which will address one or more of the above objects or which will address objects apparent from the below disclosure as well as from the description of exemplary embodiments.
  • [0011]
    Thus, corresponding to a first aspect, a medical device is provided comprising a reservoir adapted to contain a fluid drug in an interior thereof, and a pump assembly comprising. The pump assembly comprises a pump inlet, a pump outlet and an internal flow path arranged there between. The pump assembly further comprises a fluid connector comprising an inlet and an outlet, wherein the fluid connector is arranged to be operated from an initial state in which the fluid connector is arranged within the interior of the pump and an actuated state in which fluid communication is established between the interior of the reservoir and the interior of the pump assembly via the fluid connector and with the outlet of the fluid connector being arranged in the flow path of the pump assembly. In this way a pump assembly is provided with a build-in actuatable means for connecting the pump assembly to a reservoir
  • [0012]
    The fluid actuator may be actuated by any suitable means arranged within or outside the pump assembly. For example, the pump assembly may comprise an actuation opening allowing an external member to engage the fluid connector to thereby operate the fluid connector from the initial to the actuated state, or the fluid connector may be released or activated by electric means housed within the pump assembly.
  • [0013]
    In an exemplary embodiment the pump inlet and the pump outlet and, if provided, the actuation opening comprise seals which in the initial state seal the interior of the pump and thereby the flow path and the fluid connector in an initial sterile state. The seals may be of any suitable type, e.g. gas penetratable seals allowing a sterilizing gas to penetrate the seals after they have been applied. In case the device is sterilized using radiation also seals not penetratable to a gas may be used.
  • [0014]
    The fluid connector may comprise a pointed inlet end, and the reservoir may comprise a penetratable portion allowing the pointed fluid connector inlet end to be inserted there through. Advantageously, the penetratable portion of the reservoir comprises a self-sealing needle-penetratable septum, e.g. made from a rubber material or an elastomeric compound. Correspondingly, the pump outlet may comprise a self-sealing needle-penetratable septum allowing a pointed transcutaneous device to be inserted there through.
  • [0015]
    The pump assembly may be in the form of e.g. a mechanical pump (e.g. a membrane pump, a piston pump or a roller pump) in combination with electronically controlled actuation means, a mechanically driven pump (e.g. driven by a spring), a gas driven pump or a pump driven by an osmotic engine. In an exemplary embodiment, the flow path comprises a variable volume pump chamber, the flow path advantageously further comprising an inlet valve associated with the pump inlet and an outlet valve associated with the pump outlet.
  • [0016]
    In an exemplary embodiment the medical device further comprises a transcutaneous device adapted to penetrate the skin of a subject (e.g. comprising a pointed end), the transcutaneous device being arranged or adapted to be arranged in fluid communication with the pump outlet.
  • [0017]
    In the context of the present invention, the transcutaneous device (which term also covers the similar terms transcutaneous access device and transcutaneous access tool traditionally used in this technical field) may be in the form of a pointed hollow infusion needle, a micro needle array, or a combination of a relatively flexible per se blunt cannula with a pointed insertion needle may provide a pointed transcutaneous device, the insertion needle being retractable after insertion of the blunt portion of the transcutaneous device. In the latter case the portion of the transcutaneous device actually retracted by the retraction means of the present invention does not necessarily comprise a pointed end allowing the combined transcutaneous device to be inserted through the skin, such a pointed end being withdrawn during insertion of the transcutaneous device. The cannula is advantageously soft and flexible relative to the insertion needle which typically is a solid steel needle. In the disclosure of the present invention as well as in the description of the exemplary embodiments, reference will mostly be made to a transcutaneous device in the form of an infusion needle. The length of the transcutaneous device may be chosen in accordance with the actual application, e.g. a hollow steel needle which may be inserted at a substantially right angle relative to the skin surface may have an inserted length of 2-8 mm, preferably 3-5 mm, whereas a cannula which may also be inserted at an oblique angle relative to the skin surface may be somewhat longer, e.g. 4-20 mm.
  • [0018]
    In a further exemplary embodiment the invention provides a medical assembly comprising a medical device as disclosed above, further comprising a transcutaneous device unit having a transcutaneous device comprising a pointed end adapted to penetrate the skin of a subject, and a mounting surface adapted for application to the skin of a subject, wherein the transcutaneous device unit and the medical device are adapted to be secured to each other in a situation of use, and wherein the transcutaneous device is adapted to be arranged in fluid communication with the pump outlet. The fluid communication between the transcutaneous device and the pump assembly may be established when the transcutaneous device unit and the medical device are secured to each other, just as the fluid connector may be operated from the initial to the actuated state when the transcutaneous device unit and the medical device are secured to each other.
  • [0019]
    Corresponding to a further aspect, a medical device comprising a transcutaneous unit and a reservoir unit is provided, wherein the transcutaneous unit comprises transcutaneous means for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The reservoir unit comprises a reservoir adapted to contain a fluid drug, the reservoir comprising an outlet allowing the transcutaneous means to be arranged in fluid communication with an interior of the reservoir, and expelling means for, in a situation of use, expelling a fluid drug out of the reservoir and through the skin of the subject via the transcutaneous means. The transcutaneous unit and the reservoir unit further comprise coupling means allowing the reservoir unit to be secured to the transcutaneous unit in the situation of use. The transcutaneous device unit and the reservoir unit may comprise housings within which the transcutaneous device respectively the reservoir and the expelling assembly is arranged.
  • [0020]
    The term “transcutaneous” covers all forms of administration in which a fluid is transported through a portion of the skin, e.g. intradermal or subcutaneous administration. The transcutaneous means may be in the form of a transcutaneous device, a jet injection means or electrodes allowing an ionic agent to permeate from a predetermined site on the surface of skin into the subcutaneous tissue of the subject by using the principle of iontophoresis. For a more thorough discussion of iontophoresis reference is made to U.S. Pat. No. 6,622,037 hereby incorporated by reference. Depending on the nature of the transcutaneous means the expelling means may be of different configuration and nature. For example, when one or more hollow infusion needles or cannulas are used, the expelling means may be arranged to force or suck the fluid drug from the reservoir, whereas in the case of iontophoresis the expelling means would be means for applying a current over a set of electrodes, i.e. “driving” means.
  • [0021]
    Corresponding to a yet further aspect, a medical device comprising a transcutaneous device unit and a reservoir unit is provided, wherein the transcutaneous device unit comprises a transcutaneous device comprising a pointed end adapted to penetrate the skin of a subject, and a mounting surface for application to the skin of the subject. The reservoir unit comprises a reservoir adapted to contain a fluid drug, and an expelling assembly adapted for cooperation with the reservoir to expel the fluid drug out of the reservoir and through the skin of the subject via the transcutaneous device. The transcutaneous device unit and the reservoir unit are further adapted to be secured to each other in a situation of use thereby allowing a fluid communication to be established between the reservoir and the transcutaneous device. The transcutaneous device unit and the reservoir unit may comprise releasable coupling means allowing the reservoir unit to be secured to the transcutaneous device unit in a situation of us. Such a medical device comprising two units may also be considered a medical system.
  • [0022]
    The term expelling assembly covers an aggregation of components or structures which in combination provides that a fluid can be expelled from the reservoir. The expelling assembly may e.g. be a mechanical pump (e.g. a membrane pump, a piston pump or a roller pump) in combination with electronically controlled actuation means, a mechanically driven pump (e.g. driven by a spring), a gas driven pump or a pump driven by an osmotic engine.
  • [0023]
    The mounting surface is adapted for application against the skin of a subject (e.g. user or patient) and may be held in contact with the skin by attaching means external to the mounting surface (e.g. coupling means allowing the medical device to be coupled to a skin mountable device, or an adhesive bandage or a dressing) or by adhesive means provided on the mounting surface. The mounting surface may also be adapted for mounting towards the skin via an interposed component of a skin mountable device, e.g. a skin mountable device may comprise a receiving portion to which the medical device is attached, the transcutaneous device being inserted into the skin through an aperture in the receiving portion.
  • [0024]
    By the above arrangement different concepts can be realized. For example, by providing at least two different of one of the units, it will be possible to provided two or more combinations, wherein each combination of a transcutaneous device unit and a reservoir unit provides an assembly will have different capabilities as discussed in further detail below. In case the units are provided with releasable coupling means, one of the units can be exchanged with a new or different unit yet allowing the other unit to be re-used, thereby lengthening the operational life of the re-used unit. Thus, the present invention provides in an exemplary embodiment a device in which the components providing the interface with the user is incorporated in a first unit whereas the components providing the drug delivery per se is incorporated in a second unit, this allowing the combined components to be combined or exchanged in a simple, reliable and user-friendly way.
  • [0025]
    For example, the reservoir unit may be provided with an amount of drug and a delivery pump comprising an energy source allowing the drug to be delivered over e.g. 10 days, whereas the transcutaneous device unit may be provided with a transcutaneous device and an adhesive surface on the mounting surface having an expected (or recommended) operational life of 2 days, this allowing the reservoir unit to be used with 5 transcutaneous device units over a period of 10 days, this considerably lowering the total costs of using the combined device. The reservoir may be pre-filled or adapted to be filled one or more times.
  • [0026]
    On the other hand, a transcutaneous device unit may be provided with e.g. a needle or a soft cannula, and adhesive means (e.g. of the type used for attaching colostomy bags) allowing the needle unit to be mounted and used over an extended period of time, the reservoir unit having a shorter expected operational life, e.g. when relatively large amounts of drugs have to be infused. Alternatively, different reservoir units with different types of drugs may be used in combination with such a “long-term” mounted needle unit.
  • [0027]
    For ease of use, the fluid communication between the needle and the reservoir may be established when the needle unit and the reservoir unit are secured to each other, just as the expelling means may be activated when the needle unit and the reservoir unit are secured to each other and de-activated when the units are released from each other. Indeed, one or both of the operations may also be performed manually by the user.
  • [0028]
    In an exemplary embodiment the expelling assembly comprises a pump having an inlet adapted to be arranged in fluid communication with the outlet of the reservoir, and an outlet adapted to be arranged in fluid communication with the transcutaneous device, thereby allowing the transcutaneous device to be arranged in fluid communication with the interior of the reservoir. By such an arrangement the pump will serve as a suction pump drawing drug from the reservoir which consequently will have to be either collapsible or vented in case a non-collapsible reservoir is used. The expelling assembly may also be in the form of an arrangement adapted to pressurize the reservoir, e.g. an arrangement for driving a piston in reservoir comprising a displaceable piston. The reservoir unit may comprise more than one reservoir and more than one expelling assembly. For example, a single expelling assembly may be used to expel drug from more than one reservoir, either simultaneously thereby mixing drugs or alternating, or each reservoir may be provided with an expelling assembly which may be connected to a common transcutaneous device or to individual transcutaneous devices, e.g. the transcutaneous device unit may comprise more than one transcutaneous device adapted to be connected to a expelling assembly.
  • [0029]
    In order to provide an initially sterile flow path through the pump, the flow path may be arranged between the inlet and outlet such that the inlet and outlet seal the interior of the pump and thereby the flow path in an initial sterile state. By this arrangement it will not be necessary to provide the reservoir unit as an entirely sterile unit—indeed, the drug will have to be provided in a sterile state.
  • [0030]
    In an exemplary embodiment, the reservoir unit is transformable from an initial condition in which there is no fluid communication between the pump and the reservoir to a non-reversible operating condition in which fluid communication is established between the inlet means of the pump and the outlet means of the reservoir when the pump unit is secured to a needle unit for the first time. By this arrangement it is avoided that undesired matter is introduced into the reservoir during re-connection between the pump and the reservoir.
  • [0031]
    To secure a clean connection between the pump and the reservoir, a separate fluid connector may be arranged within the interior of the pump in the initial condition. Such a fluid connector may comprise a pointed inlet end and an outlet, whereas the inlet of the pump and the outlet of the reservoir may be in the form of two needle-penetratable septa. By this arrangement the pointed end of the fluid connector, e.g. a connection needle, can be moved through the two septa and thus between the initial condition and an operating condition in which fluid communication is established between the interior of the reservoir and the interior of the pump via the fluid connector, the outlet of the fluid connector being arranged in the flow path. Advantageously the fluid connector is moved between its two positions as the reservoir unit is connected to a transcutaneous device unit for the first time. Correspondingly, during such a first connection two fluid communications will be established (between the transcutaneous device of the transcutaneous device and the pump, and between the pump and the reservoir), whereas during subsequent connections only a single new fluid communication will be established (between the transcutaneous device of the transcutaneous device unit and the pump).
  • [0032]
    In an exemplary embodiment the transcutaneous device comprises a first portion having a pointed distal end, and a second portion in fluid communication with the first portion and having a second end. Advantageously the second end of the transcutaneous device is pointed and the outlet means of the pump comprises a needle-penetratable septum allowing a fluid communication to be established between the second end of the transcutaneous device and the interior of the pump, preferably as the two units are connected to each other.
  • [0033]
    Correspondingly, in a further aspect the present invention provides a pump having an inlet means adapted to be arranged in fluid communication with a fluid supply, and an outlet means, the pump comprising an internal flow path arranged between the inlet and outlet means, the inlet and outlet means sealing the interior of the pump and thereby the flow path in an initial sterile condition, wherein a fluid connection means is arranged within the interior of the pump in the initial condition, the fluid connection means comprising an inlet end and an outlet, whereby the fluid connection means is arranged to be moved between the initial condition and to an operating condition in which the inlet end projects from the pump inlet means, whereby a fluid communication can be established between the fluid supply and the interior of the pump via the fluid connection means and with the outlet of the fluid connection means being arranged in the flow path.
  • [0034]
    The transcutaneous device unit may be supplied with e.g. a needle projecting from the mounting surface, however, to limit the risk of accidental needle injuries, the pointed end of the transcutaneous device is advantageously moveable between an initial position in which the pointed end is retracted relative to the mounting surface, and an extended position in which the pointed end projects relative to the mounting surface. Depending on the intended method of mounting the device on the user, the transcutaneous device may be moved between the two positions as the two units are connected to each, as would be appropriate in case the transcutaneous device unit is mounted on the skin of the user before the reservoir unit is connected. However, in case the two units are intended to be connected to each other before assembled units are mounted on the skin of the user, the transcutaneous device unit advantageously comprises user-actuatable actuation means for moving the pointed end of the transcutaneous device between the initial and the extended position.
  • [0035]
    To prevent inadvertent actuation of the transcutaneous device before the two units are assembled, the transcutaneous device unit may comprise means for blocking the actuation means, the blocking means being released when the transcutaneous device unit and the reservoir unit are secured to each other, thereby allowing the actuation means to be actuated.
  • [0036]
    To further reduce the likelihood of transcutaneous device injuries, the pointed end of the transcutaneous device may be moveable between the extended position in which the pointed end projects relative to the mounting surface, and a retracted position in which the pointed end is retracted relative to the mounting surface. Correspondingly, the combined device may comprise user-actuatable retraction means for moving the pointed end of the transcutaneous device between the extended and the retracted position when the retraction means is actuated.
  • [0037]
    To prevent re-use of the transcutaneous device, the transcutaneous device may be permanently locked in its retraced position. To prevent user-errors the actuation means for introducing the transcutaneous device may in an initial condition cover the retraction means, actuation of the actuation means uncovering the retraction means. For example, the actuation means may be in the form of gripping means (e.g. a strip) which is removed from the device, whereby removal triggers transcutaneous device insertion and at the same time uncovers the retraction for withdrawing the transcutaneous device.
  • [0038]
    As described above, the expelling assembly may be activated and deactivated when the two units are assembled and disassembled, however, the actuation and retraction means may also be used to activate respectively deactivate the expelling assembly. Just as for the initial connection between the pump and the reservoir, the initial activation of the expelling assembly may result in electronic control means being activated resulting in start of pumping action, whereas subsequent deactivation will only deactivate the actual pump action, the control means still being active (e.g. counting the time since initial activation of the control means).
  • [0039]
    In the above disclosure of the invention the two units have been described primarily as “unitary” units, however, this is only an exemplary configuration and these two “main” units may in case it is deemed desirable be subdivided into further units. For example, the reservoir unit may be provided with an exchangeable control unit, this allowing different types of control units to be connected to the reservoir unit per se. e.g. a first type of control unit may provide a single delivery profile, a second control unit may be programmable to thereby modify the delivery pattern, or a control third unit may comprise means allowing the control unit to communicate with external means. In the latter case the control unit may be controlled using a cordless remote control. Correspondingly, the reservoir may be exchangeable allowing different sizes of reservoirs or different types of drugs to be used.
  • [0040]
    In a further aspect of the invention, a transcutaneous device unit is provided as described above and being adapted to be used in combination with a reservoir unit as disclosed above. Correspondingly, the invention also provides a reservoir unit as disclosed above, the reservoir unit being adapted to be used in combination with a transcutaneous device unit as disclosed above. In an exemplary embodiment such a transcutaneous device unit may be provided with a hollow needle comprising a pointed distal end with an outlet opening and being adapted to penetrate the skin of a subject, and a pointed proximal end with an inlet opening forming a fluid inlet means, the fluid inlet means being adapted to be arranged in fluid communication with a fluid supply. By this arrangement the needle provides a hydraulically stiff fluid communication between the needle inlet and outlet openings (e.g. made from metal), this allowing early occlusion detection by monitoring a pressure build-up upstream of the needle.
  • [0041]
    In a yet further aspect, a system is provided comprising a first needle unit and a first reservoir unit as disclosed above in combination with a least one further needle unit or reservoir unit as disclosed above, the further unit(s) having different capabilities than the first units. The different capabilities may relate to any constructional feature of the units, e.g. the type of needle, the type of user-actuatable means, the type of delivery/pump means, or the type of reservoir/drug.
  • [0042]
    More specifically, in an exemplary embodiment a system is provided comprising a transcutaneous device unit as disclosed above, and a plurality of reservoir units, each comprising a reservoir containing a fluid drug, and an expelling assembly for expelling fluid drug from the reservoir. The transcutaneous device unit and the reservoir units comprise mating coupling means allowing a reservoir unit to be secured to the transcutaneous device unit to provide fluid communication between the reservoir and the transcutaneous device, wherein each combination of a transcutaneous device unit and a reservoir unit provides an assembly having different capabilities. The different capabilities may be realized providing e.g. reservoir units with different amounts of the same drugs, reservoir units with different drugs or variants of a given drug, reservoir units adapted to expel drug at different preset rates, reservoir units adapted to expel at fixed respectively selectable rates. One of the reservoir units may be provided with a processor controlling the expelling assembly and a receiver operatable coupled to the controller for receiving flow instructions from a separate control device and delivering the flow instructions to the processor. The receiver may be a wireless receiver. The reservoir units may further be provided with different input means (e.g. for wireless or non-wireless connection, or manual input), or different output means (e.g. for wireless or non-wireless connection, different display means, or different alarm means).
  • [0043]
    In a further exemplary embodiment, a system is provided comprising a plurality of transcutaneous device units as described above, and a reservoir unit comprising a reservoir containing a fluid drug, and an expelling assembly for expelling fluid drug from the reservoir. The transcutaneous device units and the reservoir unit comprise mating coupling means allowing a transcutaneous device unit to be secured to the reservoir unit to provide fluid communication between the reservoir and the transcutaneous device, wherein each combination of a transcutaneous device unit and a reservoir unit provides an assembly having different capabilities. The different capabilities may be realized by providing the transcutaneous device units with different transcutaneous devices such as a hollow subcutaneous needle, a cannula and insertion needle assembly, and a micro needle array, by providing different adhesives, by providing different insertion or retraction means, or by providing different coupling means.
  • [0044]
    The present invention also provides a method comprising the steps of providing a transcutaneous device unit comprising a transcutaneous device and a mounting surface, providing a reservoir unit comprising a reservoir adapted to contain a fluid drug, and an expelling assembly for expelling fluid drug from the reservoir, the method comprising the further step of assembling the transcutaneous device unit and the reservoir unit to provide a fluid communication between the reservoir and the transcutaneous device. The fluid communication between the transcutaneous device and the reservoir may be established when the two units are assembled or it may be established when the assembled device is further actuated, both options being covered by the above definition. The method may comprise the further steps of mounting the mounting surface to a skin surface of a subject, and, after mounting the mounting surface to the skin surface of the subject, actuating the transcutaneous device to establish a fluid communication between the reservoir and the subject.
  • [0045]
    A further method provides a drug delivery device dispensing a drug at a preset rate, the method comprising the steps of providing a system comprising a transcutaneous device unit comprising a transcutaneous device and a mounting surface adapted for application to the skin of a subject, the system further comprising a plurality of reservoir units, each comprising a reservoir containing a fluid drug, and an expelling assembly for expelling fluid drug from the reservoir at a preset rate, selecting a reservoir unit having a desired preset rate, and assembling the transcutaneous device unit and the selected reservoir unit to provide a fluid communication between the reservoir and the transcutaneous device.
  • [0046]
    As used herein, the term “drug” is meant to encompass any drug-containing flowable medicine capable of being passed through a delivery means such as a hollow needle in a controlled manner, such as a liquid, solution, gel or fine suspension. Representative drugs include pharmaceuticals such as peptides, proteins, and hormones, biologically derived or active agents, hormonal and gene based agents, nutritional formulas and other substances in both solid (dispensed) or liquid form. In the description of the exemplary embodiments reference will be made to the use of insulin. Correspondingly, the term “subcutaneous” infusion is meant to encompass any method of transcutaneous delivery to a subject. Further, the term needle (when not otherwise specified) defines a piercing member adapted to penetrate the skin of a subject.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0047]
    In the following the invention will be further described with references to the drawings, wherein
  • [0048]
    FIGS. 1-11 shows in perspective views the sequences of use for a first embodiment of a drug delivery device,
  • [0049]
    FIG. 12 shows a further embodiment of a reservoir unit,
  • [0050]
    FIG. 13 shows in a non-assembled state a needle unit and a reservoir unit for a further embodiment of a drug delivery device,
  • [0051]
    FIG. 14 shows an exploded view of the needle unit of FIG. 13,
  • [0052]
    FIG. 15 shows a perspective view of the needle unit of FIG. 13 in a first state,
  • [0053]
    FIG. 16 shows a perspective view of the needle carrier of FIG. 14,
  • [0054]
    FIG. 17 shows a perspective view of the needle unit of FIG. 13 in a second state,
  • [0055]
    FIG. 18 shows a side view of the needle unit of FIG. 13,
  • [0056]
    FIG. 19 shows a further perspective view of the needle unit of FIG. 13,
  • [0057]
    FIG. 20 shows perspective view of the interior of the reservoir unit of FIG. 13,
  • [0058]
    FIG. 21 shows an exploded view of a further reservoir unit,
  • [0059]
    FIG. 22A shows a schematic overview of a pump connected to a reservoir,
  • [0060]
    FIG. 22B shows an exploded view of a pump assembly,
  • [0061]
    FIG. 22C shows a cross-sectional view of the pump assembly of FIG. 22C,
  • [0062]
    FIGS. 22D and 22E show partial cross-sectional views of the pump assembly of FIG. 22C,
  • [0063]
    FIGS. 23A and 23B show in a schematic representation a transcutaneous device in the form of a cannula and insertion needle combination,
  • [0064]
    FIG. 24 shows a perspective view of a further drug delivery device,
  • [0065]
    FIGS. 25A-25D show different expelling means suitable for use with the invention,
  • [0066]
    FIG. 26 shows a medical device with a modular reservoir unit, and
  • [0067]
    FIG. 27 shows a modular system for a medical device.
  • [0068]
    In the figures like structures are mainly identified by like reference numerals.
  • DESCRIPTION OF EXEMPLARY EMBODIMENTS
  • [0069]
    When in the following terms such as “upper” and “lower”, “right” and “left”, “horizontal” and “vertical” or similar relative expressions are used, these only refer to the appended figures and not to an actual situation of use. The shown figures are schematic representations for which reason the configuration of the different structures as well as there relative dimensions are intended to serve illustrative purposes only.
  • [0070]
    Firstly, with reference to FIGS. 1-12 an embodiment of a drug delivery device will be described focusing primarily on the directly user-oriented features. The transcutaneous device unit 2 comprises a transcutaneous device in the form of a hollow infusion needle and will thus in the following be termed a needle unit, however, the needle may be replaced with any desirable transcutaneous device suitable for delivery of a fluid drug.
  • [0071]
    More specifically, FIG. 1 shows a perspective view of medical device in the form of a modular skin-mountable drug delivery device 1 comprising a patch-like needle unit 2 and a reservoir unit 5. When supplied to the user each of the units are preferably enclosed in its own sealed package (not shown).
  • [0072]
    The needle unit comprises a base portion 10 with a lower mounting surface adapted for application to the skin of a user, and a housing portion 20 in which a hollow infusion needle (not shown) is arranged. The needle comprises a first needle portion having a pointed distal end adapted to penetrate the skin of a user, and a second pointed end adapted to be arranged in fluid communication with the reservoir unit. In the shown embodiment the pointed end of the needle is moveable between an initial position in which the pointed end is retracted relative to the mounting surface, and an extended position in which the pointed end projects relative to the mounting surface. Further, the needle is moveable between the extended position in which the pointed end projects-relative to the mounting surface, and a retracted position in which the pointed end is retracted relative to the mounting surface. The needle unit further comprises user-gripable actuation means in the form of a first strip-member 21 for moving the pointed end of the needle between the initial and the second position when the actuation means is actuated, and user-gripable retraction in the form of a second strip-member 22 means for moving the pointed end of the needle between the extended and the retracted position when the retraction means is actuated. As can be seen, the second strip is initially covered by the first strip. The housing further comprises user-actuatable male coupling means 40 in the form of a pair of resiliently arranged hook members adapted to cooperate with corresponding female coupling means on the reservoir unit, this allowing the reservoir unit to be releasable secured to the needle unit in the situation of use. In the shown embodiment the base portion comprises a relatively rigid upper portion 11 attached to a more flexible adhesive sheet member 12 having a lower adhesive surface providing the mounting surface per se, the adhesive surface being supplied with a peelable protective sheet. The base portion also comprises a ridge member 13 adapted to engage a corresponding groove on the reservoir unit.
  • [0073]
    The reservoir unit 5 comprises a pre-filled reservoir containing a liquid drug formulation (e.g. insulin) and expelling means in the form of an electronically controlled pump for expelling the drug from the reservoir through the needle in a situation of use. The reservoir unit has a generally flat lower surface adapted to be mounted onto the upper surface of the base portion, and comprises a protruding portion 50 adapted to be received in a corresponding cavity of the housing portion 20 as well as female coupling means 51 adapted to engage the corresponding hook members 31 on the needle unit. The protruding portion provides the interface between the two units and comprises a pump outlet and contact means (not shown) allowing the pump to be started as the two units are assembled. The lower surface also comprises a window (not to be seen) allowing the user to visually control the contents of the reservoir.
  • [0074]
    First step in the mounting procedure is to assemble the two units by simply sliding the reservoir unit into engagement with the needle unit (FIG. 2). When the hook members properly engage the reservoir unit a “click” sound is heard (FIG. 3) signalling to the user that the two units have been properly assembled. If desired, a visual or audible signal may also be generated. Thereafter the user removes the peelable sheet 14 to uncover the adhesive surface (FIG. 4) where after the device can be attached to a skin surface of the user, typically the abdomen (FIG. 5). Infusion of drug is started by gripping and pulling away the actuation strip 21 as indicated by the arrow whereby the needle is inserted followed by automatic start of the infusion (FIG. 6). The needle insertion mechanism may be supplied in a pre-stressed state and subsequently released by the actuation means or the needle insertion may be “energized” by the user. A “beep” signal confirms that the device is operating and drug is infused. The reservoir unit is preferably provided with signal means and detection means providing the user with an audible alarm signal in case of e.g. occlusion, pump failure or end of content.
  • [0075]
    After the device has been left in place for the recommended period of time for use of the needle unit (e.g. 48 or 72 hours)—or in case the reservoir runs empty or for other reasons—it is removed from the skin by gripping (FIG. 7) and pulling (FIG. 8) the retraction strip 22 as indicated by the arrows which leads to retraction of the needle followed by automatic stop of drug infusion where after the strip which is attached to the adhesive patch is used to remove the device from the skin surface (FIG. 9).
  • [0076]
    When the device has been removed the two units are disengaged by simultaneously depressing the two hook members 31 as indicated by the arrows (FIG. 10) allowing the reservoir unit 5 to be pulled out of engagement with the needle unit 2 as indicated by the arrow (FIG. 11) which can then be discarded. Thereafter the reservoir unit can be used again with fresh needle units until it has been emptied.
  • [0077]
    The reservoir unit may be supplied with a fixed basal infusion rate or it may be supplied as an adjustable unit (FIG. 12) with adjustment means 55 allowing the infusion rate to be set by a physician and/or the user/patient. The reservoir unit may also be provided with means allowing the control means to be programmed or set electronically (not shown).
  • [0078]
    The device described with reference to FIGS. 1-11 may also be used in alternative ways. For example, the needle unit may be mounted to the skin after which the reservoir is attached. Depending on the configuration of the needle unit, it may be possible or prevented that the needle is introduced before the reservoir unit is attached.
  • [0079]
    FIG. 13 shows a further embodiment of medical device 500 substantially corresponding to the embodiment of FIG. 1, the device comprising a patch-like needle unit 502 and a thereto attachable reservoir unit 505.
  • [0080]
    FIG. 14 shows an exploded perspective view of the needle unit comprising an upper housing portion 510, a needle carrier 520 and a thereto mounted infusion needle 530, an actuation member 540, a release member 550, a lower housing portion 560 and a sheet member 570. The actuation member comprises a user gripable portion 541 and a needle actuation portion 542, and the release member comprises a user gripable portion 551 and a needle retraction portion 552. In the assembled state as shown in FIG. 15, the upper and lower housing portions form a housing 503 in which the needle and the needle carrier is mounted, the actuation and release members being operatable connected to the needle carrier with the user gripable portions arranged outside the housing. In contrast to the FIG. 1 embodiment does the needle unit not comprise a base plate portion but instead two ridge members 561 extending from the housing, the ridge members and the lower surface of the housing being mounted on the flexible sheet member which is provided with a lower adhesive layer 571 on its lower surface allowing the needle unit to be attached to a skin site of a subject. The sheet member further comprises an opening 572 arranged in register with a lower protrusion 565 provided around the exit aperture for the transcutaneous device, just as the sheet is provided with a large number of small perforations to improve breathability through the sheet. The housing 503 is provided with user actuatable coupling means 511 allowing a reservoir unit to be attached to and released from the needle unit 505, the reservoir unit comprising corresponding mating coupling means 506 as well as a display 587. The display may indicate e.g. proper function of the unit, the amount of drug in the reservoir or different error conditions.
  • [0081]
    As seen is the user gripable portion 551 of the release member initially covered by a portion of the actuation member, this reducing the probability that the user erroneously uses the release member instead of the actuation member. Further, the actuation and release members (or portion thereof) may be colour coded to further assist the user to correctly use the device. For example, the actuation member may be green to indicate “start” whereas the release member may be red to indicate “stop”.
  • [0082]
    FIG. 16 shows in perspective the needle carrier 520 with the needle 530 and the needle actuation portion 542 of the actuation member 540. The needle actuation portion comprises two legs 543 allowing it to slide relative to the housing, the legs being arranged through respective openings 563 in the housing. The needle carrier is adapted to be connected to a hinge member 562 of the lower housing portion to thereby allow the needle carrier and thereby the needle to pivot corresponding to a pivoting axis defined by a hinge. In the shown embodiment is the needle carrier in the form a bent sheet metal member, the carrier comprising an upper arm 521 and a lower arm 522 connected to each other by a hinge portion 523 allowing the lower arm to pivot relative to the upper arm and corresponding to the pivoting axis. The lower arm forms a tray in which the hollow infusion needle 530 is mounted (e.g. by welding or adhesive), the needle having a distal pointed portion 531 adapted to penetrate the skin of the subject, the distal portion extending generally perpendicular to the mounting surface of the needle unit, and a proximal portion 532 arranged substantially corresponding to the pivoting axis and adapted to engage a fluid supply. Thus, when a portion of the upper arm is mounted in the housing, the lower arm can pivot between a first retracted position in which the distal portion of the needle is retracted within the housing, and a second extended position in which the distal portion projects relative to the mounting surface. In the shown embodiment the needle carrier provides the drive means for moving the lower arm between the two positions. This may as in the present embodiment be provided by the elastic properties of the sheet material per se corresponding to the hinge portion, or alternatively an additional spring may be provided between the two arms to thereby urge them apart. To lock the lower part in an energized, releasable first position, the upper arm is provided with a flexible release arm 526 comprising a catch 527 supporting and arresting the lower arm in its first downwardly biased position, as well as a release portion 528 engaging a ramp surface 544 of the needle actuation portion 542, the catch further comprising an inclined edge portion 529 adapted to engage the lower arm when the latter is moved from its extended to its retracted position as will be described in greater detail below.
  • [0083]
    To actuate the needle the user grips the flexible strip forming the user gripable portion 541 (which preferably comprises adhesive portions to hold it in its shown folded initial position) and pulls the needle actuation portion 542 out of the housing, the actuation member 540 thereby fully disengaging the housing. More specifically, when the ramp surface 544 is moved it forces the latch 527 away from the lower arm to thereby release it, after which the release portion 528 disengages the ramp allowing the two legs to be pulled out of the housing. As seen in FIG. 17, when the actuation member is removed the user gripable portion 551 of the release member is exposed. As for the actuation member, the user gripable portion of the release member preferably comprises adhesive portions to hold it in its shown folded initial position.
  • [0084]
    In the shown embodiment the release member is in the form of a strip formed from a flexible material and having an inner and an outer end, the strip being threaded through an opening 512 in the housing, the strip thereby forming the user gripable portion 551 and the needle retraction portion 552, the inner end of the strip being attached to the housing and the outer end of the strip being attached to a peripheral portion of the sheet member 570 or, alternatively, a peripheral portion of the housing. In the projection shown in FIG. 18 the release member is shown in its initial position, the retraction portion forming a loop 555 arranged below the lower arm of the needle carrier, this position allowing the lower arm to be moved to its actuated position and thereby the needle to its extended position.
  • [0085]
    When the user decides to remove the needle unit from the skin, the user grips the user gripable portion 551, lifts it away from the housing and pulls it upwardly whereby the loop shortens thereby forcing the lower arm upwardly, this position corresponding to an intermediate release state. By this action the lower arm engages the inclined edge portion 529 of the catch 527 thereby forcing it outwardly until it snaps back under the lower arm corresponding to the position shown in FIG. 16. As the actuation member 540 has been removed from the needle unit, the needle carrier is irreversibly locked in its retracted position. When the user further pulls in the release member, the peripheral portion of the sheet member to which the release member is attached will be lifted off the skin, whereby the needle unit with its attached reservoir unit can be removed from the skin, this as shown and described with reference to FIGS. 7-9.
  • [0086]
    Advantageously, the actuation and release members may be formed and arranged to communicate with the reservoir unit (not shown). For example, one of the legs of the actuation member may in its initial position protrude through the housing to thereby engage a corresponding contact on the reservoir unit, this indicating to the reservoir unit that the needle unit has been attached, whereas removal of the actuation member will indicate that the needle has been inserted and thus that drug infusion can be started. Correspondingly, actuation of the release member can be used to stop the pump.
  • [0087]
    In FIG. 19 the side of the needle unit 502 which connects to the reservoir unit is shown. In addition to the two ridge members 561 and the user actuatable coupling means 511 the needle unit comprises further structures which connects to and/or engages the reservoir unit to provide a functional interface with the reservoir unit. More specifically, the needle unit comprises a fluid inlet provided by the pointed proximal portion 532 of the needle projecting from the needle unit and adapted to engage a fluid outlet of the reservoir unit, an actuator 515 projecting from the needle unit and adapted to engage and actuate a fluid connector in the reservoir unit (see below), and first and second contact actuators 548, 558 adapted to engage corresponding contacts on the reservoir unit. The first contact actuator is provided by the distal end of one of the legs 543 of the needle actuator projecting through an opening in the housing, and the second contact actuator is provided by a hinged portion of the housing connected to the needle retraction portion 552 of the release member 550. When the needle unit is first connected to the reservoir unit both contact actuators will protrude from the housing and engage the corresponding contacts on the reservoir unit thereby indicating that that a needle unit has been connected. When the needle is actuated the first contact actuator will be withdrawn and thereby disengage the corresponding contact on the reservoir unit to start pump actuation. When the needle is retracted the second contact actuator will pivot and disengage the corresponding contact on the reservoir unit to stop pump actuation.
  • [0088]
    FIG. 20 shows the reservoir unit with an upper portion of the housing removed. The reservoir unit comprises a reservoir 760 and an expelling assembly comprising a pump assembly 300 and control and actuation means 580, 581 therefore. The pump assembly comprises an outlet 322 for connection to a transcutaneous access device (e.g. the needle 530) and an opening 323 allowing an internal fluid connector to be actuated, see below. The reservoir 560 is in the form of prefilled, flexible and collapsible pouch comprising a needle-penetratable septum adapted to be arranged in fluid communication with the pump assembly, see below. The shown pump assembly is a mechanically actuated membrane pump, however, the reservoir and expelling means may be of any suitable configuration, e.g. as disclosed with reference to FIGS. 25A-25D.
  • [0089]
    The control and actuation means comprises a pump actuating member in the form of a coil actuator 581 arranged to actuate a piston of the membrane pump, a PCB or flex-print to which are connected a microprocessor 583 for controlling, among other, the pump actuation, contacts 588, 589 cooperating with the contact actuators on the needle unit, signal generating means 585 for generating an audible and/or tactile signal, a display (not shown) and an energy source 586. The contacts are preferably protected by membranes which may be formed by flexible portions of the housing.
  • [0090]
    In FIG. 21 an exploded view of the reservoir unit 505 of FIG. 13 is shown, the unit comprising an upper housing member 507, a lower housing member 508 with a transparent area 509 and grooves 504 to receive the ridge members 561 extending from the needle unit, a flexible reservoir 760 with a rounded edge portion 762 on which a septum member 761 is mounted, a pump assembly 300 with actuator and a circuit board (not shown) arranged above the reservoir and comprising electronic components for controlling actuation of the pump. The upper and lower housing members comprise reservoir mounting means in the form of opposed upper and lower ridge portions 780 (the lower not seen) adapted to engage and mount the reservoir in the housing. Each ridge portion comprises a central cut-out portion 781 adapted to engage the septum member on its opposed surfaces when the housing members are assemble thereby locking the reservoir in place within the housing. The degree of locking will be determined by the pressure exerted on the septum member, the elastic properties of the septum member and the friction between the ridge and the septum member. On each side of the cut-out portion the ridge portions comprise a straight portion 782 which may aid in mounting the reservoir in the housing. The straight portions may engage the initially prefilled reservoir to help lock it in place, however, as the reservoir is emptied and flattens this grip may lessen. In contrast, the engagement with the septum is adapted to properly hold the reservoir in place as the reservoir is emptied. The straight portions may also be adapted to pinch and fully flatten the reservoir thus serving as an additional mounting means. Additional mounting means (not shown) may engage and grip the reservoir at other means (not shown) may engage and grip the reservoir at other locations, e.g. along the welded edges 765.
  • [0091]
    With reference to FIG. 22A a schematic overview of a pump connected to a reservoir is shown, the pump comprising the following general features: a fluid connection 391 to reservoir a reservoir 390, a safety valve 392, inlet and outlet valves 393, 394, a pump chamber 395 with an associated piston 396, and an outlet 397. The arrows indicate the flow direction between the individual components. When the piston is moved downwards (in the drawing) a relative negative pressure will build up inside the pump chamber which will cause the inlet valve to open and subsequently fluid will be drawn form the reservoir through the open primary side of the safety valve. When the piston is moved upwards (in the drawing) a relative overpressure will build up in the pump chamber which will cause the inlet valve to close and the outlet valve and the safety valve to open whereby fluid will flow from the pump chamber through the outlet valve and the secondary side of the safety valve to the outlet. As appears, in normal operation the safety valve allows fluid passage during both intake and expelling of fluid and is thus “passive” during normal operation. However, in case the reservoir is pressurized (as may happen for a flexible reservoir) the elevated pressure in the reservoir will be transmitted to both the primary side of the safety valve and, via the pump chamber, the secondary side of the safety valve in which case the pressure on the primary side of the safety valve will prevent the secondary side to open.
  • [0092]
    In FIG. 22B an exploded view of a pump assembly 300 utilizing the pump principle depicted in FIG. 22A is shown, the pump assembly (in the following also referred to as a pump) being suitable for use with the reservoir units of FIGS. 1-13. The pump is a membrane pump comprising a piston-actuated pump membrane with flow-controlled inlet- and outlet-valves. The pump has a general layered construction comprising first, second and third members 301, 302, 303 between which are interposed first and second membrane layers 311, 312, whereby a pump chamber 341 is formed by the first and second members in combination with the first membrane layer, a safety valve 345 is formed by the first and third members in combination with the first membrane layer, and inlet and outlet valves 342, 343 are formed by the second and third members in combination with the second membrane layer (see FIG. 22C). The layers are held in a stacked arrangement by an outer clamp 310. The pump further comprises an inlet 321 and an outlet 322 as well as a connection opening 323 which are all three covered by respective membranes 331, 332, 333 sealing the interior of the pump in an initial sterile state. The membranes are penetratable or breakable (e.g. made from paper) by a needle or other member introduced through a given seal. The outlet further comprises a self-sealing, needle-penetratable septa 334 (e.g. of a rubber-like material) allowing the pump to be connected to an outlet needle. As shown in FIG. 22C a fluid path (indicated by the dark line) is formed between the inlet 321 (see below) and the inlet valve 342 via the primary side of the safety valve 345, between the inlet valve, pump chamber 345 and the outlet valve 343, and between the outlet valve and the outlet 322 via the secondary side of the safety valve, the fluid paths being formed in or between the different layers. The pump also comprises a piston 340 for actuating the pump membrane, the piston being driven by external driving means (not shown).
  • [0093]
    The pump further comprises a fluid connector in the form of hollow connection needle 350 slidably positioned in a needle chamber 360 arranged behind the connection opening, see FIG. 22D. The needle chamber is formed through the layers of the pump and comprises an internal sealing septum 315 through which the needle is slidably arranged, the septum being formed by the first membrane layer. The needle comprises a pointed distal end 351, a proximal end on which is arranged a needle piston 352 and a proximal side opening 353 in flow communication with the distal end, the needle and the piston being slidably arranged relative to the internal septum and the chamber. As can be appreciated form FIG. 22D the needle piston in its initial position is bypassed by one or more radially placed keyways 359. These are provided in order to allow steam sterilisation and to vent the air otherwise trapped when the fluid connector is moved forward in the needle chamber.
  • [0094]
    The above-described pump assembly may be provided in a drug delivery device of the type shown in FIGS. 1-20. In a situation of use where the reservoir unit is attached to a needle unit the proximal end 532 of the infusion needle is introduced through the outlet seal and septum 334 of the pump, and the actuator 515 (see FIG. 19) is introduced through the connection membrane 333. By this action the connection needle is pushed from its initial position as shown in FIG. 22D to a actuated position as shown in FIG. 22E in which the distal end is moved through the inlet membrane 331 and further through the needle-penetratable septum of a nearby located reservoir, this establishing a flow path between the reservoir and the inlet valve via the proximal opening 353 in the needle. In this position a seal is formed between the needle piston and the needle chamber.
  • [0095]
    As appears, when the two units are disconnected, the proximal end 532 of the infusion needle is withdrawn from the pump outlet whereas the connection needle permanently provides fluid communication between the pump and the reservoir.
  • [0096]
    In the above described embodiments, the transcutaneous device has been in the form of a unitary needle device (e.g. an infusion needle as shown or a needle sensor (not shown)), however, the transcutaneous device may also be in the form of a cannula or a sensor in combination with an insertion needle which is withdrawn after insertion thereof. For example, the first needle portion may be in the form of a (relatively soft) infusion cannula (e.g. a Teflon® cannula) and a there through arranged removable insertion needle. This type of cannula needle arrangement is well known from so-called infusion sets, such infusion sets typically being used to provide an infusion site in combination with (durable) infusion pumps.
  • [0097]
    Thus, FIGS. 23A and 23B show in a schematic representation how a cannula and insertion needle combination can be arranged within a housing 601 of in a given medical device 600 (partly shown), e.g. an infusion device or an infusion set. More specifically, the medical device comprises a transcutaneous assembly 650 comprising a combination of a relatively soft cannula 651 (which e.g. may be of the soft “Teflon®” type) carried by a lower member 653 and a pointed insertion needle 661 (e.g. made from medical grade stainless steel) slidably arranged within the cannula and carried by an upper member 663, both members being mounted to allow axial displacement of the cannula respectively the insertion needle. The cannula comprises a proximal inlet (not shown) allowing it to be or to be arranged in fluid communication with a fluid source. The medical device further comprises a base plate 620 with an opening 621 for the cannula as well as a release member 622. The lower member comprises an elastomeric seal 652 through which the insertion needle is arranged. The cannula and the insertion needle may be straight or curved dependent upon how the two members are mounted in the device, e.g. arcuate corresponding to a pivoting axis or straight corresponding to linear movement as illustrated. The upper member comprises a coupling member 667 locking the members together in an initial position with distal end of the insertion needle extending from the distal opening of the cannula as shown in FIG. 23A, and the base plate comprises coupling member 657 for locking the lower member in an extended position with distal end of the cannula extending through the opening in the base plate (see FIG. 23B). Between the housing of the device and the upper member a first spring 668 is arranged biasing the upper member upwards. Correspondingly, the device also comprises a second spring 658 biasing the lower member upwardly. The medical device further comprises a gripping tab 676 and a pulling member 677 corresponding to the embodiment shown in FIG. 1.
  • [0098]
    In a situation of use the assembly is moved downwardly, either manually or by a releasable insertion aid, e.g. a spring loaded member acting through an opening in the housing (not shown) whereby the cannula with the projecting insertion needle is inserted through the skin of a subject. In this position the lower member engages the coupling member 657 to thereby lock the cannula in its extended position, just as the coupling member 667 is released by the release member 622 thereby allowing the upper member to return to its initial position by means of the first spring.
  • [0099]
    When the user intends to remove the delivery device from the skin surface, the user grips the gripping portion of the tab and pulls it in a first direction substantially in parallel with the skin surface, by which action the flexible strip 677 releases the coupling member 657 from the lower member whereby the lower member and thereby the cannula is retracted by means of the second spring. When the cannula has been withdrawn from the skin, the user uses the now unfolded tab to pull off the entire delivery device from the skin surface, for example by pulling the tab in a direction away from the skin surface.
  • [0100]
    In FIG. 24 an embodiment of a device adapted for the latter mounting procedure described with reference to FIGS. 1-12 is shown (i.e. mounting the needle unit first).
  • [0101]
    More specifically, FIG. 24 shows a perspective view of medical device in the form of a drug delivery device 100 comprising a needle housing 110, a base member 130 with a lower mounting surface 133 adapted for application to the skin of the subject, and a separate pump unit 150. In the shown embodiment the base member comprises a relatively rigid upper portion 131 attached to a more flexible adhesive patch member 132 having a lower adhesive surface providing the mounting surface per se. The needle housing may be formed integrally with the base member or attached thereto as a separate unit, the two elements in combination forming a platform unit. In the shown embodiment the needle unit comprises a housing 111 within which a hollow needle 112 is pivotally arranged.
  • [0102]
    The housing comprises first and second openings (or windows) covered by first and second cover means. In the shown embodiment the first cover means is in the form of a needle penetratable rubber membrane 121 and the second cover membrane is in the form of a breakable paper sheet allowing components to be introduced into the interior of the housing. The paper sheet is penetratable to sterilizing gases, the paper sheet, the rubber membrane and the housing in combination providing a sterility barrier for the encapsulated needle portion.
  • [0103]
    The needle comprises a first needle portion 113 having a first pointed end adapted to penetrate the skin of the subject, the first needle portion extending generally perpendicular to the mounting surface, and a second needle portion 114 in fluid communication with the first needle portion via an intermediate needle portion 115 and having a second pointed end, the second needle portion being arranged substantially in parallel with the mounting surface. The needle is connected to the housing by a mounting member 117 allowing the needle to pivot corresponding to an axis defined by the second needle portion, whereby the needle is moveable between an initial sterile position in which the first needle portion is retracted relative to the mounting surface, and a second position in which the pointed end of the first needle portion projects through the rubber septum and relative to the mounting surface. The housing also comprises a biasing member 118 biasing the needle towards the initial position. Often, the “downstream” portion of a needle (here: the first portion) is referred to as the distal portion, and the “upstream” portion of a needle (here: the second portion) is referred to as the proximal portion.
  • [0104]
    The reservoir (or pump) unit 150 comprises a housing in which a reservoir and expelling means are arranged. The reservoir is adapted to contain a liquid drug (e.g. prefilled or adapted to be filled by a user) and comprises an outlet means in the form of a protruding needle penetratable septum 155 adapted to be arranged in fluid communication with the second needle portion. The expelling means (not shown) is adapted for in a situation of use to expel a drug out of the reservoir and through the skin of the subject via the hollow needle. The pump unit further comprises a ramp member 156 arranged next to the reservoir outlet. The reservoir and expelling means may be of any suitable configuration, e.g. as disclosed with reference to FIGS. 25A-25D.
  • [0105]
    The mounting platform comprises a receiving portion, the receiving portion and the pump unit comprising mating coupling means 160 allowing the pump unit to be secured to the platform unit. The mating coupling means may be releasable allowing a durable or multi-use pump unit to be attached a number of times to a disposable platform unit.
  • [0106]
    In a situation of use, the platform unit is mounted on the skin of a user (e.g. by adhesive means arranged on the mounting surface) and the pump unit is attached and locked to the platform unit by sliding it into engagement therewith substantially in parallel with the mounting surface. During the latter operation the protruding septum and the ramp member is moved into engagement with the needle, thereby breaking the paper barrier cover 122, during which operation fluid communication is established between the second needle portion and the reservoir, just as the needle is pivoted from its initial to its second position, the first pointed needle end thereby penetrating the rubber membrane and the skin of the user.
  • [0107]
    After the pump unit has been connected and the needle introduced subcutaneously, the pump can be started. This may happen either automatically as the two units are connected or by separate user-actuatable starting means, e.g. a start button (not shown).
  • [0108]
    In an alternative embodiment (not shown), the second needle portion may be fixedly (i.e. non-rotationally) attached to the mounting member 117, the intermediate needle portion 115 being elastically bend as it is forced downwardly by the ramp member 156. In such an arrangement the biasing member 118 may be dispensed with.
  • [0109]
    In the above-described embodiments a delivery device has been described comprising a flexible reservoir in combination with an example of an expelling means. However, the reservoir and the expelling means may be of any type which would be suitable for arrangement within a skin-mountable drug delivery device. Further, as the needle of the present invention also may be in the form of a needle sensor, the interior of the medical device may comprise sensor means adapted to cooperate with the needle sensor.
  • [0110]
    In FIGS. 25A-25E examples of expelling means suitable for use with the present invention are shown schematically, however, these are merely examples, just as the shown arrangement of the individual components not necessarily are suitable for direct application in the above shown delivery devices. More specifically, FIG. 25A shows a pump arrangement comprising a drug-containing cartridge 1010 forming a reservoir and having a distal closure member 1011 allowing a needle to be connected, and a piston 1015 slidingly arranged there within, a flexible toothed piston rod 1020 (for example as disclosed in U.S. Pat. No. 6,302,869), an electric motor 1030 which via a worm-gear arrangement 1031 drives the piston rod to expel drug from the cartridge, the motor being controlled by control means 1040 and the energy for the control means and the motor being provided by a battery 1050. The pump may be activated when the needle is inserted (by means not shown) or by separate user-actuatable means (not shown) after the inserter has been detached form the delivery device.
  • [0111]
    FIG. 25B shows a pump arrangement comprising a drug-containing cartridge 1110 having distal and proximal closure members 1111, 1112, and a piston 1115 slidingly arranged there within, gas generating means 1120 in fluid communication with the interior of the cartridge via conduit 1121 for driving the piston to expel drug from the cartridge, the gas generating means being controlled by control means 1140 and the energy for the control means and the gas generation being provided by a battery 1150. The pump may be activated as indicated above. A detailed disclosure of such gas generating means for a drug delivery device can be found in e.g. U.S. Pat. No. 5,858,001.
  • [0112]
    FIG. 25C shows a pump arrangement comprising a drug-containing cartridge 1210 having distal and proximal closure members 1211, 1212, and a piston slidingly 1215 arranged there within, an osmotic engine 1220 in fluid communication with the interior of the cartridge via conduit 1221 for driving the piston to expel drug from the cartridge. The osmotic engine comprises a first rigid reservoir 1225 containing a salt-solution and a second collapsible reservoir 1226 containing water, the two reservoirs being separated by a semi-permeable membrane 1227. When supplied to the user, the fluid connection 1228 between the second reservoir and the membrane is closed by a user-severable membrane (e.g. a weak weld) which, when severed, will allow the osmotic process to start as water is drawn from the second reservoir through the membrane and into the first reservoir. The pump may be activated as indicated above. A detailed disclosure of the osmotic drive principle can be found in e.g. U.S. Pat. No. 5,169,390.
  • [0113]
    FIG. 25D shows a pump arrangement comprising a drug-containing flexible reservoir 1310 arranged within a rigid fluid-filled secondary reservoir 1311 in fluid communication with a primary reservoir 1320 through a conduit 1330 comprising a flow restrictor 1331. The primary reservoir is in the form of a cartridge with a moveable piston 1321 and contains a viscous drive fluid. A spring 1340 is arranged to act on the piston to drive fluid from the first to the second reservoir thereby expelling drug from the flexible reservoir when the latter is connected to an infusion needle (not shown). The flow rate will be determined by the pressure generated by the spring in the drive fluid, the viscosity of the drive fluid and the flow resistance in the flow restrictor (i.e. bleeding hole principle). The pump may be activated by straining the spring or by releasing a pre-stressed spring, either when the needle is inserted (by means not shown) or by separate user-actuatable means (not shown) after the inserter has been detached from the delivery device. An example of this principle used for drug infusion is known from DE 25 52 446. In an alternative configuration, the drug reservoir may be pressurized directly to expel the drug via a flow restrictor, e.g. as disclosed in U.S. Pat. No. 6,074,369.
  • [0114]
    In FIG. 26 is shown a medical device 900 corresponding to the embodiment of FIGS. 1-11, however, the reservoir unit has a modular design comprising a “durable” control unit 910 adapted to be mounted on a reservoir unit 920 comprising a reservoir and an expelling assembly controllable by the control unit through contacts 921. The transcutaneous device unit 930 may be the same as in FIGS. 1-11. The transcutaneous device unit and the reservoir unit comprise mating coupling means (931) allowing the reservoir unit to be secured to the transcutaneous device unit to provide fluid communication between the reservoir and the transcutaneous device, and the controller unit and the reservoir unit comprise mating coupling means (917, 921) allowing the controller unit to be secured to the reservoir unit to control the expelling assembly. The control unit may comprise one or more of the following features: a vibrator, a RF transmitter, a RF receiver, a display, a bolus button 918 (as shown) or other user input means, a back-up battery, a memory. Further, the control unit may be adapted to provide a fixed flow rate or it may be programmable (e.g. via a remote control) to provide a given rate or a given profile. The different control units may also be used with different reservoir units (e.g. comprising different drugs or different amounts of drugs), or with different needle units (e.g. comprising a needle or a soft cannula). As stated above, the controller may be used as a durable device by the user, however, (simpler) versions of the controller may come pre-attached to a reservoir unit and be used as a means to provide a varity of disposable devices.
  • [0115]
    FIG. 27 shows a modular system comprising a number of different types of control units in addition to a basic needle patch unit 930 and a basic reservoir unit 920. A remote controller 940 may be used in combination with some of the control units. The control unit may be in the form of a remotely controllable unit 911 which can only be controlled from a remote controller. A variant 912 thereof may add a bolus button 918 allowing the user to take a bolus of drug without having to use the remote controller. The control unit may be provided as a varity of preprogrammed control units 913, each providing a fixed flow rate as indicated on the unit. Such a unit is intended for use without a remote controller and may include a display 919 as shown. A programmable control unit 914 may also be provided, this allowing e.g. a medical practitioner to program the control unit for an individual patient. A dummy 915 represents any of the disclosed control units in combination with a reservoir unit and a needle unit.
  • [0116]
    In the above description of the preferred embodiments, the different structures and means providing the described functionality for the different components have been described to a degree to which the concept of the present invention will be apparent to the skilled reader. The detailed construction and specification for the different components are considered the object of a normal design procedure performed by the skilled person along the lines set out in the present specification.

Claims (14)

  1. 1. A medical device, comprising:
    a reservoir (760) adapted to contain a fluid drug in an interior thereof,
    a pump assembly (300) comprising:
    a pump inlet (321), a pump outlet (322) and an internal flow path (341, 342, 343) arranged there between,
    a fluid connector (350) comprising an inlet (351) and an outlet (353),
    wherein the fluid connector is arranged to be operated from an initial state in which the fluid connector is arranged within the interior of the pump and an actuated state in which fluid communication is established between the interior of the reservoir and the interior of the pump assembly via the fluid connector and with the outlet of the fluid connector being arranged in the flow path of the pump assembly.
  2. 2. A medical device as in claim 1, wherein the pump inlet and the pump outlet comprise seals which in the initial state seal the interior of the pump and thereby the flow path and the fluid connector in an initial sterile state.
  3. 3. A medical device as in claim 1, comprising an actuation opening allowing an external member to engage the fluid connector to thereby operate the fluid connector from the initial to the actuated state,
  4. 4. A medical device as in claim 3, wherein the pump inlet, the pump outlet and the actuation opening comprise seals which in the initial state seal the interior of the pump and thereby the flow path and the fluid connector in an initial sterile state.
  5. 5. A medical device as in claim 1, wherein the fluid connector comprises pointed inlet end, the reservoir comprising a penetratable portion (761) allowing the pointed fluid connector inlet end to be inserted there through.
  6. 6. A medical device as in claim 5, wherein the penetratable portion of the reservoir comprises a self-sealing needle-penetratable septum.
  7. 7. A medical device as in claim 1, wherein the flow path comprising a variable volume pump chamber.
  8. 8. A medical device as in claim 7, the flow path further comprising an inlet valve associated with the pump inlet and an outlet valve associated with the pump outlet.
  9. 9. A medical device as in claim 1, wherein the pump outlet comprises a self-sealing needle-penetratable septum allowing a pointed transcutaneous device to be inserted there through.
  10. 10. A medical device as in claim 1, further comprising an actuator for actuating the pump assembly.
  11. 11. A medical device as in claim 1, further comprising a transcutaneous device (530) comprising a pointed end adapted to penetrate the skin of a subject, the transcutaneous device being arranged or adapted to be arranged in fluid communication with the pump outlet.
  12. 12. A medical assembly comprising a medical device as in any of claims 1-10, further comprising a transcutaneous device unit (502) comprising:
    a transcutaneous device (530) comprising a pointed end adapted to penetrate the skin of a subject,
    a mounting surface (571) adapted for application to the skin of a subject,
    wherein the transcutaneous device unit and the medical device are adapted to be secured to each other in a situation of use, and
    wherein the transcutaneous device is adapted to be arranged in fluid communication with the pump outlet.
  13. 13. A medical assembly as in claim 12, wherein fluid communication between the transcutaneous device and the pump assembly is established when the transcutaneous device unit and the medical device are secured to each other.
  14. 14. A medical assembly as in claim 11, wherein the fluid connector is operated from the initial to the actuated state when the transcutaneous device unit and the medical device are secured to each other.
US11407647 2003-10-21 2006-04-20 Internal fluid connector Abandoned US20070021733A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DKPA200301545 2003-10-21
DKPA200301545 2003-10-21
EP20030024276 EP1525873A1 (en) 2003-10-23 2003-10-23 Container with septum member
EP03024276.2 2003-10-23
EP20030024626 EP1527792A1 (en) 2003-10-27 2003-10-27 Medical injection device mountable to the skin
EP03024626.8 2003-10-27
DKPA200301590 2003-10-28
DKPA200301590 2003-10-28
US51883203 true 2003-11-10 2003-11-10
US51888103 true 2003-11-10 2003-11-10
US51883603 true 2003-11-10 2003-11-10
PCT/DK2004/000727 WO2005037350A3 (en) 2003-10-21 2004-10-21 Internal fluid connector for establishing a fluid connection

Publications (1)

Publication Number Publication Date
US20070021733A1 true true US20070021733A1 (en) 2007-01-25

Family

ID=46062839

Family Applications (2)

Application Number Title Priority Date Filing Date
US11407647 Abandoned US20070021733A1 (en) 2003-10-21 2006-04-20 Internal fluid connector
US11411081 Active 2026-08-16 US8062253B2 (en) 2003-10-21 2006-04-25 Medical skin mountable device

Family Applications After (1)

Application Number Title Priority Date Filing Date
US11411081 Active 2026-08-16 US8062253B2 (en) 2003-10-21 2006-04-25 Medical skin mountable device

Country Status (2)

Country Link
US (2) US20070021733A1 (en)
KR (1) KR20060099520A (en)

Cited By (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060095014A1 (en) * 2003-05-08 2006-05-04 Novo Nordisk A/S External inserter for transcutaneous device
US20060142698A1 (en) * 2003-05-08 2006-06-29 Novo Nordisk A/S Internal needle inserter
US20060182637A1 (en) * 2005-02-16 2006-08-17 Sarcos Investments Lc. Method and apparatus for reducing free flow risk
US20070049865A1 (en) * 2003-08-01 2007-03-01 Novo Nordisk A/S Retraction means for transcutaneous device
US20070104596A1 (en) * 2004-03-30 2007-05-10 Novo Nordisk A/S Actuator system comprising lever mechanism
US20070185455A1 (en) * 2006-02-07 2007-08-09 Fangrow Thomas F Jr Infusion set
US20080157713A1 (en) * 2004-06-14 2008-07-03 Massachusetts Institute Of Technology Electrochemical methods, devices, and structures
US20080167641A1 (en) * 2005-05-13 2008-07-10 Novo Nordisk A/S Medical Device Adapted To Detect Disengagement Of A Transcutaneous Device
US20080215006A1 (en) * 2004-09-22 2008-09-04 Novo Nordisk A/S Medical Device with Transcutaneous Cannula Device
US20080228056A1 (en) * 2007-03-13 2008-09-18 Michael Blomquist Basal rate testing using frequent blood glucose input
WO2008142636A2 (en) * 2007-05-22 2008-11-27 Koninklijke Philips Electronics N.V. Wearable drug delivery device
WO2008142640A1 (en) * 2007-05-22 2008-11-27 Koninklijke Philips Electronics N.V. Wearable drug delivery device
US20080300534A1 (en) * 2007-05-30 2008-12-04 Michael Blomquist Insulin pump based expert system
US20090012472A1 (en) * 2004-09-22 2009-01-08 Novo Nordisk A/S Medical Device with Cannula Inserter
US20090014320A1 (en) * 2004-06-14 2009-01-15 Massachusetts Institute Of Technology Electrochemical actuator
US20090028824A1 (en) * 2007-07-26 2009-01-29 Entra Pharmaceuticals, Inc. Systems and methods for delivering drugs
US20090048563A1 (en) * 2004-12-06 2009-02-19 Novo Nordisk A/S Ventilated Skin Mountable Device
US20090062778A1 (en) * 2006-03-13 2009-03-05 Novo Nordisk A/S Medical System Comprising Dual-Purpose Communication Means
US20090069868A1 (en) * 2006-03-11 2009-03-12 Henrik Bengtsson Secure Pairing of Electronic Devices using Dual Means of Communication
US20090076451A1 (en) * 2005-01-24 2009-03-19 Nova Nordisk A/S Medical Device with Protected Transcutaneous Device
US20090112166A1 (en) * 2003-11-18 2009-04-30 Icu Medical, Inc. Infusion set
US20090163874A1 (en) * 2006-04-26 2009-06-25 Novo Nordisk A/S Skin-Mountable Device in Packaging Comprising Coated Seal Member
US20090192471A1 (en) * 2006-05-31 2009-07-30 Calibra Medical, Inc. Disposable infusion device with locked cannula
US20090254041A1 (en) * 2006-06-06 2009-10-08 Krag Christian Roege Assembly Comprising Skin-Mountable Device and Packaging Therefore
US20100049128A1 (en) * 2008-08-18 2010-02-25 Calibra Medical, Inc. Drug infusion system with reusable and disposable components
US20100063448A1 (en) * 2007-03-06 2010-03-11 Novo Nordisk A/S Pump assembly comprising actuator system
US20100217233A1 (en) * 2009-02-20 2010-08-26 Ranft Elizabeth A Method and device to anesthetize an area
US20100222765A1 (en) * 2007-01-24 2010-09-02 Smiths Medical Asd, Inc. Correction factor testing using frequent blood glucose input
US20100274751A1 (en) * 2007-05-24 2010-10-28 Smith Medical Asd, Inc. Expert system for insulin pump therapy
US20110008206A1 (en) * 2007-10-31 2011-01-13 Novo Nordisk A/S Non-Porous Material as Sterilization Barrier
US7872396B2 (en) 2004-06-14 2011-01-18 Massachusetts Institute Of Technology Electrochemical actuator
US20110022025A1 (en) * 2009-07-23 2011-01-27 Becton, Dickinson And Company Medical device having capacitive coupling communication and energy harvesting
US20110040251A1 (en) * 2008-01-09 2011-02-17 Michael Blomquist Infusion pump with add-on modules
US20110054285A1 (en) * 2009-09-02 2011-03-03 Becton, Dickinson And Company Flexible and Conformal Patch Pump
US20110054390A1 (en) * 2009-09-02 2011-03-03 Becton, Dickinson And Company Extended Use Medical Device
US20110060289A1 (en) * 2003-05-08 2011-03-10 Novo Nordisk A/S Integrated package
US7923895B2 (en) 2004-06-14 2011-04-12 Massachusetts Institute Of Technology Electrochemical methods, devices, and structures
US7967795B1 (en) 2010-01-19 2011-06-28 Lamodel Ltd. Cartridge interface assembly with driving plunger
US8152779B2 (en) 2008-12-30 2012-04-10 Medimop Medical Projects Ltd. Needle assembly for drug pump
US8157769B2 (en) 2009-09-15 2012-04-17 Medimop Medical Projects Ltd. Cartridge insertion assembly for drug delivery system
US8247946B2 (en) 2004-06-14 2012-08-21 Massachusetts Institute Of Technology Electrochemical actuator
US8337457B2 (en) 2010-05-05 2012-12-25 Springleaf Therapeutics, Inc. Systems and methods for delivering a therapeutic agent
US8348898B2 (en) 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
US8368285B2 (en) 2010-12-17 2013-02-05 Massachusette Institute Of Technology Electrochemical actuators
US8430849B2 (en) 2010-09-24 2013-04-30 Perqflo, Llc Infusion pumps and plunger pusher position-responsive cartridge lock for infusion pumps
USD702834S1 (en) 2011-03-22 2014-04-15 Medimop Medical Projects Ltd. Cartridge for use in injection device
US8795230B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Adjustable height needle infusion device
US8814831B2 (en) 2010-11-30 2014-08-26 Becton, Dickinson And Company Ballistic microneedle infusion device
US8905972B2 (en) 2010-11-20 2014-12-09 Perqflo, Llc Infusion pumps
US8915879B2 (en) 2010-09-24 2014-12-23 Perqflo, Llc Infusion pumps
US8945071B2 (en) 2010-09-02 2015-02-03 Becton, Dickinson And Company Self-injection device having needle cover with activation preventer
US8961469B2 (en) 2009-12-16 2015-02-24 Becton, Dickinson And Company Self-injection device
US8996089B2 (en) 2009-06-30 2015-03-31 Arkray, Inc. Continuous analysis device and sample component control system
US9011164B2 (en) 2013-04-30 2015-04-21 Medimop Medical Projects Ltd. Clip contact for easy installation of printed circuit board PCB
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US9173997B2 (en) 2007-10-02 2015-11-03 Medimop Medical Projects Ltd. External drug pump
US9216249B2 (en) 2010-09-24 2015-12-22 Perqflo, Llc Infusion pumps
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
US9416775B2 (en) 2014-07-02 2016-08-16 Becton, Dickinson And Company Internal cam metering pump
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
US9452261B2 (en) 2010-05-10 2016-09-27 Medimop Medical Projects Ltd. Low volume accurate injector
US9463280B2 (en) 2012-03-26 2016-10-11 Medimop Medical Projects Ltd. Motion activated septum puncturing drug delivery device
US9498573B2 (en) 2010-09-24 2016-11-22 Perqflo, Llc Infusion pumps
US9555187B2 (en) 2009-12-16 2017-01-31 Becton, Dickinson And Company Self-injection device
US9579461B2 (en) 2009-12-16 2017-02-28 Becton, Dickinson And Company Self-injection device
US9623173B2 (en) 2012-03-05 2017-04-18 Becton, Dickinson And Company Wireless communication for on-body medical devices
US9656019B2 (en) 2007-10-02 2017-05-23 Medimop Medical Projects Ltd. Apparatuses for securing components of a drug delivery system during transport and methods of using same
US9669160B2 (en) 2014-07-30 2017-06-06 Tandem Diabetes Care, Inc. Temporary suspension for closed-loop medicament therapy
US9717850B2 (en) 2009-12-16 2017-08-01 Becton, Dickinson And Company Self-injection device
US9744297B2 (en) 2015-04-10 2017-08-29 Medimop Medical Projects Ltd. Needle cannula position as an input to operational control of an injection device
US9782536B2 (en) 2009-01-12 2017-10-10 Becton, Dickinson And Company Infusion set and/or patch pump having at least one of an in-dwelling rigid catheter with flexible features and/or a flexible catheter attachment
US9795534B2 (en) 2015-03-04 2017-10-24 Medimop Medical Projects Ltd. Compliant coupling assembly for cartridge coupling of a drug delivery device
US9795361B2 (en) 2011-03-02 2017-10-24 General Electric Company Device for assisting with the handling of an instrument or tool
USD804019S1 (en) 2016-09-26 2017-11-28 West Pharmaceutical Services, Inc. Injector device
US9833562B2 (en) 2009-12-16 2017-12-05 Becton, Dickinson And Company Self-injection device
USD804650S1 (en) 2016-09-26 2017-12-05 West Pharmaceutical Services, Inc. Injector device
USD805190S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD805187S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD805189S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD805186S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD805188S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD805632S1 (en) 2016-10-26 2017-12-19 West Pharmaceutical Services, Inc. Injector device
USD805633S1 (en) 2016-10-26 2017-12-19 West Pharmaceutical Services, Inc. Injector device
USD806235S1 (en) 2016-10-26 2017-12-26 West Pharmaceutical Services, Inc. Injector device
USD806234S1 (en) 2016-10-26 2017-12-26 West Pharmaceutical Services, Inc. Injector device
USD806863S1 (en) 2016-10-26 2018-01-02 West Pharmaceutical Services, Inc. Injector device
USD807499S1 (en) 2016-10-26 2018-01-09 West Pharmaceutical Services, Inc. Injector device
USD808011S1 (en) 2016-10-26 2018-01-16 West Pharmaceutical Services, Inc. Injector device
US9889256B2 (en) 2013-05-03 2018-02-13 Medimop Medical Projects Ltd. Sensing a status of an infuser based on sensing motor control and power input
US9950109B2 (en) 2010-11-30 2018-04-24 Becton, Dickinson And Company Slide-activated angled inserter and cantilevered ballistic insertion for intradermal drug infusion

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939324B2 (en) * 2000-11-30 2005-09-06 Biovalve Technologies, Inc. Fluid delivery and measurement systems and methods
US7517335B2 (en) * 2002-02-18 2009-04-14 Cequr Aps Device for administering of medication in fluid form
US7530968B2 (en) 2003-04-23 2009-05-12 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
KR101158939B1 (en) 2004-03-26 2012-06-21 우노메디컬 에이/에스 Injector device for infusion set
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
US7686787B2 (en) * 2005-05-06 2010-03-30 Medtronic Minimed, Inc. Infusion device and method with disposable portion
US20150057615A1 (en) * 2005-11-08 2015-02-26 Asante Solutions Infusion Pump System
DK1962925T3 (en) * 2005-12-23 2009-08-03 Unomedical As Delivery Device
WO2007095093A3 (en) 2006-02-09 2008-01-17 Deka Products Lp Pumping fluid delivery systems and methods using force application assembly
EP1988958B2 (en) 2006-02-28 2016-03-16 Unomedical A/S Inserter for infusion part
US20070299399A1 (en) * 2006-03-16 2007-12-27 Seattle Medical Technologies Infusion device with dosage dial control
JP2009532117A (en) 2006-03-30 2009-09-10 ヴァレリタス,エルエルシーValeritas,Llc Multi cartridge fluid delivery device
CA2653631A1 (en) 2006-06-07 2007-12-13 Unomedical A/S Inserter
EP2026862A1 (en) * 2006-06-08 2009-02-25 Medingo Ltd. System for detecting an occlusion in a tube
KR20090028701A (en) 2006-06-09 2009-03-19 우노메디컬 에이/에스 Mounting pad
KR20090037492A (en) * 2006-08-02 2009-04-15 우노메디컬 에이/에스 Cannula and delivery device
US20100004597A1 (en) * 2006-08-02 2010-01-07 Unomedical A/S Insertion Device
US7794434B2 (en) 2006-08-23 2010-09-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US20080097291A1 (en) 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
US8277415B2 (en) 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8512288B2 (en) 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8137314B2 (en) 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US7455663B2 (en) 2006-08-23 2008-11-25 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US7811262B2 (en) 2006-08-23 2010-10-12 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7828764B2 (en) 2006-08-23 2010-11-09 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US8840586B2 (en) 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US9259175B2 (en) * 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
EP1917990A1 (en) 2006-10-31 2008-05-07 Unomedical A/S Infusion set
WO2008078318A3 (en) * 2006-12-22 2008-09-25 Gavriel J Iddan Systems and devices for sustained delivery of therapeutic fluid
KR20090117749A (en) * 2007-02-02 2009-11-12 우노메디컬 에이/에스 Injection site for injecting medication
US20100140125A1 (en) * 2007-02-02 2010-06-10 Orla Mathiasen Injection Site for Injecting Medication
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
JP5102350B2 (en) 2007-04-30 2012-12-19 メドトロニック ミニメド インコーポレイテッド A method using a reservoir filling / bubble management / infusion medium delivery system and the system
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
CA2691369A1 (en) 2007-06-20 2008-12-24 Unomedical A/S A catheter and a method and an apparatus for making such catheter
CA2691341A1 (en) 2007-07-03 2009-01-08 Unomedical A/S Inserter having bistable equilibrium states
DE602008005153D1 (en) 2007-07-10 2011-04-07 Unomedical As Inserter with two feathers
KR20100049576A (en) 2007-07-18 2010-05-12 우노메디컬 에이/에스 Insertion device with pivoting action
ES2644639T3 (en) * 2007-09-28 2017-11-29 Calibra Medical, Inc. Disposable infusion device with dual valve system
US8226607B2 (en) * 2007-09-28 2012-07-24 Calibra Medical, Inc. Disposable infusion device with dual valve system
WO2009046989A3 (en) * 2007-10-11 2009-06-18 Hoffmann La Roche Carrier for an infusion system
DE102007049446A1 (en) * 2007-10-16 2009-04-23 Cequr Aps Catheter introducer
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US20090204077A1 (en) * 2008-02-13 2009-08-13 Hasted Soren B Moulded Connection Between Cannula and Delivery Part
WO2009103759A1 (en) 2008-02-20 2009-08-27 Unomedical A/S Insertion device with horizontally moving part
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
CN101745177A (en) * 2008-11-28 2010-06-23 上海百星药业有限公司;上海蓝心医药科技有限公司 Disposable drug delivery device with own power
WO2010072664A1 (en) 2008-12-22 2010-07-01 Unomedical A/S Medical device comprising adhesive pad
KR101715421B1 (en) 2009-05-04 2017-03-10 발레리타스 인코포레이티드 Fluid transfer device
US8641671B2 (en) 2009-07-30 2014-02-04 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
CN102470211B (en) 2009-07-30 2014-05-07 犹诺医药有限公司 Inserter device with horizontal moving part
CN102548598B (en) 2009-08-07 2014-09-17 犹诺医药有限公司 Delivery device with sensor and one or more cannulas
US8672873B2 (en) 2009-08-18 2014-03-18 Cequr Sa Medicine delivery device having detachable pressure sensing unit
US8547239B2 (en) 2009-08-18 2013-10-01 Cequr Sa Methods for detecting failure states in a medicine delivery device
EP2488233A4 (en) * 2009-10-13 2015-01-28 Valeritas Inc Fluid delivery device
CN102844060A (en) 2010-03-30 2012-12-26 犹诺医药有限公司 Medical devices
EP2433663A1 (en) 2010-09-27 2012-03-28 Unomedical A/S Insertion system
US9211378B2 (en) 2010-10-22 2015-12-15 Cequr Sa Methods and systems for dosing a medicament
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
EP2591815A1 (en) * 2011-11-10 2013-05-15 Debiotech S.A. Patch kit and infusion set
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
WO2014057361A3 (en) 2012-07-26 2014-07-24 Adi Mashiach Implant holder and suture guide
US9907967B2 (en) 2012-07-26 2018-03-06 Adi Mashiach Transcutaneous power conveyance device
US9861801B2 (en) 2013-02-28 2018-01-09 Kimberly-Clark Worldwide, Inc. Drug delivery device
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9421329B2 (en) 2013-03-15 2016-08-23 Tandem Diabetes Care, Inc. Infusion device occlusion detection system
USD805631S1 (en) 2016-01-21 2017-12-19 Becton, Dickinson And Company Drug delivery device with insertion mechanism button safety
USD806232S1 (en) 2016-01-21 2017-12-26 Becton, Dickinson And Company Drug delivery device with insertion mechanism

Citations (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US401678A (en) * 1889-04-16 Car for live stock
US2980032A (en) * 1959-02-27 1961-04-18 Brown Engine Products Inc Fuel pump
US4137020A (en) * 1976-12-26 1979-01-30 Nippondenso Co., Ltd. Diaphragm type air pump
US4245634A (en) * 1975-01-22 1981-01-20 Hospital For Sick Children Artificial beta cell
US4262824A (en) * 1978-02-17 1981-04-21 Baxter Travenol Laboratories, Inc. Low-current E-frame electronic magnet with a permanent magnet armature for an I. V. valving controller
US4370305A (en) * 1979-07-23 1983-01-25 Hoelzle & Chelius Kg Device for the sterilization of fluid substances
US4378015A (en) * 1981-12-21 1983-03-29 Wardlaw Stephen C Automatic injecting syringe
US4399824A (en) * 1981-10-05 1983-08-23 Air-Shields, Inc. Apparatus for detecting probe dislodgement
US4519792A (en) * 1982-12-06 1985-05-28 Abbott Laboratories Infusion pump system
US4529401A (en) * 1982-01-11 1985-07-16 Cardiac Pacemakers, Inc. Ambulatory infusion pump having programmable parameters
US4645491A (en) * 1984-03-09 1987-02-24 David Evans Surgical needle
US4657490A (en) * 1985-03-27 1987-04-14 Quest Medical, Inc. Infusion pump with disposable cassette
US4734902A (en) * 1985-05-08 1988-03-29 James T. Dennis Record player
US4753651A (en) * 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
US4755173A (en) * 1986-02-25 1988-07-05 Pacesetter Infusion, Ltd. Soft cannula subcutaneous injection set
US4894054A (en) * 1988-06-20 1990-01-16 Miskinyar Shir A Preloaded automatic disposable syringe
US4928528A (en) * 1988-07-25 1990-05-29 Cordis Corporation Arterial/venous simulator
US4994078A (en) * 1988-02-17 1991-02-19 Jarvik Robert K Intraventricular artificial hearts and methods of their surgical implantation and use
US5008110A (en) * 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5122201A (en) * 1991-11-19 1992-06-16 International Business Machines Corporation Water-soluble solder flux
US5122116A (en) * 1990-04-24 1992-06-16 Science Incorporated Closed drug delivery system
US5211201A (en) * 1986-03-04 1993-05-18 Deka Products Limited Partnership Intravenous fluid delivery system with air elimination
US5224843A (en) * 1989-06-14 1993-07-06 Westonbridge International Ltd. Two valve micropump with improved outlet
US5336052A (en) * 1993-04-28 1994-08-09 Abel Pumpen Gmbh & Co. Kg Viscous material pump
US5391950A (en) * 1993-06-24 1995-02-21 Unisys Corporation Circuit to eliminate signal chatter in the output of a fiber-optic receiver
US5390671A (en) * 1994-03-15 1995-02-21 Minimed Inc. Transcutaneous sensor insertion set
US5482473A (en) * 1994-05-09 1996-01-09 Minimed Inc. Flex circuit connector
US5485917A (en) * 1993-12-06 1996-01-23 Ethicon-Endo-Surgery Quick release package for surgical instrument
US5494415A (en) * 1994-09-12 1996-02-27 Morita; Yoshimitsu Magnetically-driven pump
US5514095A (en) * 1994-04-04 1996-05-07 Haemonetics Corporation Apparatus for heating, filtering and eliminating gas from biological fluids
US5609572A (en) * 1992-11-23 1997-03-11 Lang; Volker Cassette infusion system
US5647853A (en) * 1995-03-03 1997-07-15 Minimed Inc. Rapid response occlusion detector for a medication infusion pump
US5720391A (en) * 1996-03-29 1998-02-24 St. Jude Medical, Inc. Packaging and holder for heart valve prosthesis
US5776109A (en) * 1996-08-23 1998-07-07 Urrutia; Hector Drip chamber for intravenous fluid delivery system
US5860952A (en) * 1996-01-11 1999-01-19 C. R. Bard, Inc. Corporeal access tube assembly and method
US5913856A (en) * 1997-05-19 1999-06-22 Irvine Biomedical, Inc. Catheter system having a porous shaft and fluid irrigation capabilities
US5925017A (en) * 1995-10-11 1999-07-20 Science Incorporated Fluid delivery device with bolus injection site
US5928194A (en) * 1997-04-07 1999-07-27 Maget; Henri J. R. Self-contained liquid microdispenser
US5931814A (en) * 1994-10-28 1999-08-03 Hoffmann-La Roche Inc. Dermally affixed injection device
US5941611A (en) * 1996-01-19 1999-08-24 Hydraulik-Ring Antriebs- Und Steuerungstechnik Gmbh Actuating device for brakes of a vehicle, preferably a motor vehicle
US6045534A (en) * 1997-10-27 2000-04-04 Sarcos, Inc. Disposable fluid injection module
US6060319A (en) * 1991-12-13 2000-05-09 Diametrics Medical. Inc. Temperature stabilized fluid reference system
US6074369A (en) * 1998-02-20 2000-06-13 Becton, Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6083196A (en) * 1997-12-11 2000-07-04 Alza Corporation Device for enhancing transdermal agent flux
US6088619A (en) * 1999-02-26 2000-07-11 Implex Aktiengesellschaft Hearing Technology Device and method for aiding the positioning of an external part relative to an implantable part of a charging system for an implantable medical device
US6099512A (en) * 1999-05-10 2000-08-08 Urrutia; Hector Limited flow rate drip chamber for intravenous fluid delivery system
US6241704B1 (en) * 1901-11-22 2001-06-05 Sims Deltec, Inc. Drug pump systems and methods
US6270478B1 (en) * 1997-10-23 2001-08-07 Mernoee Morton Infusion pump system and an infusion pump unit
US6358731B1 (en) * 1999-10-20 2002-03-19 Wei K. Hsu Sterilizable cultivation system with separately attachable microfiltration membrane
US20020040208A1 (en) * 2000-10-04 2002-04-04 Flaherty J. Christopher Data collection assembly for patient infusion system
US20020040083A1 (en) * 2000-01-26 2002-04-04 Tetsuo Kuwaki Flame-retardant and flame-retarding resin composition
US20020055711A1 (en) * 2000-06-30 2002-05-09 Gilad Lavi Needle device and method thereof
US20020064468A1 (en) * 2000-11-28 2002-05-30 Duncan Wade Diaphragm for a diaphragm pump
US20030009131A1 (en) * 2000-03-13 2003-01-09 Medtronic Minimed, Inc. Leak detection system and method of using the same
US20030009133A1 (en) * 2001-04-13 2003-01-09 Kirk Ramey Drive system for an infusion pump
US20030029501A1 (en) * 2001-06-13 2003-02-13 Williamson Mark E. Vacuum demand valve
US20030060781A1 (en) * 2001-09-27 2003-03-27 Mogensen Lasse Wesseltoft Injector device for placing a subcutaneous infusion set
US20030065308A1 (en) * 2000-01-21 2003-04-03 Lebel Ronald J. Ambulatory medical apparatus with hand held communication device
US20030069546A1 (en) * 2001-10-04 2003-04-10 Sandstrom Jeffrey D. Right angle safety needle
US20030073952A1 (en) * 2001-10-12 2003-04-17 Flaherty J. Christopher Laminated patient infusion device
US6551276B1 (en) * 1998-08-18 2003-04-22 Medtronic Minimed, Inc. External infusion device with remote programming bolus estimator and/or vibration alarm capabilities
US6555986B2 (en) * 1998-10-29 2003-04-29 Minimed Inc. Method and apparatus for detection of occlusions
US6554791B1 (en) * 1999-09-29 2003-04-29 Smisson-Cartledge Biomedical, Llc Rapid infusion system
US6558351B1 (en) * 1999-06-03 2003-05-06 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
US20030088238A1 (en) * 2001-09-26 2003-05-08 Poulsen Jens Ulrik Modular drug delivery system
US20030114797A1 (en) * 2001-12-17 2003-06-19 Vaillancourt Vincent L. Safety needle with collapsible sheath
US6589229B1 (en) * 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
US20030135159A1 (en) * 1997-05-06 2003-07-17 Elan Pharma International Limited Drug delivery device
US20040051674A1 (en) * 2000-12-19 2004-03-18 Claus Mahringer Communication terminal with antenna
US6716192B1 (en) * 1997-09-30 2004-04-06 Charles F. Schroeder Medical needle having a visibly marked tip
US20040087240A1 (en) * 2002-01-31 2004-05-06 Zhizhang Chen Method of manufacturing an emitter
US20040098068A1 (en) * 2002-06-28 2004-05-20 Rafael Carbunaru Chair pad charging and communication system for a battery-powered microstimulator
US6740059B2 (en) * 2000-09-08 2004-05-25 Insulet Corporation Devices, systems and methods for patient infusion
US6749587B2 (en) * 2001-02-22 2004-06-15 Insulet Corporation Modular infusion device and method
US20040115068A1 (en) * 2002-09-27 2004-06-17 Steffen Hansen Membrane pump with stretchable pump membrane
US20040116905A1 (en) * 2002-09-09 2004-06-17 Pedersen Per Elgard Flow restrictor with safety feature
US20040127844A1 (en) * 2002-03-01 2004-07-01 Flaherty J. Christopher Flow condition sensor assembly for patient infusion device
US20040158207A1 (en) * 2001-04-06 2004-08-12 Marcel Hunn Infusion set
US20040162521A1 (en) * 2002-10-07 2004-08-19 Henrik Bengtsson Needle device comprising a plurality of needles
US20050006309A1 (en) * 2000-06-21 2005-01-13 Carlo Effenhauser Pump for low flow rates
US20050022274A1 (en) * 2003-04-18 2005-01-27 Robert Campbell User interface for infusion pump remote controller and method of using the same
US6878136B2 (en) * 2002-02-28 2005-04-12 Medical Product Specialists Huber needle with anti-rebound safety mechanism
US20050077225A1 (en) * 2003-10-10 2005-04-14 Usher Kathryn M. Apparatus and method for removing gasses from a liquid
US20050101933A1 (en) * 2003-11-10 2005-05-12 James Marrs Subcutaneous infusion device and method
US20060015063A1 (en) * 2002-11-29 2006-01-19 Buetikofer Markus Catheter head with closeable seal element
US20060017576A1 (en) * 2004-07-20 2006-01-26 Medtronic, Inc. Alert system and method for an implantable medical device
US20060020300A1 (en) * 2004-06-09 2006-01-26 David Nghiem Implantable medical device package antenna
US7052483B2 (en) * 2000-12-19 2006-05-30 Animas Corporation Transcutaneous inserter for low-profile infusion sets
US20060142698A1 (en) * 2003-05-08 2006-06-29 Novo Nordisk A/S Internal needle inserter
US7070580B2 (en) * 2003-04-01 2006-07-04 Unomedical A/S Infusion device and an adhesive sheet material and a release liner
US20070073228A1 (en) * 2005-09-26 2007-03-29 Morten Mernoe Dispensing fluid from an infusion pump system
US20070104596A1 (en) * 2004-03-30 2007-05-10 Novo Nordisk A/S Actuator system comprising lever mechanism
US20070112301A1 (en) * 2004-03-30 2007-05-17 Novo Nordisk A/S Actuator system comprising detector means
US20080009805A1 (en) * 2003-05-08 2008-01-10 Novo Nordisk A/S Integrated package
US20090163874A1 (en) * 2006-04-26 2009-06-25 Novo Nordisk A/S Skin-Mountable Device in Packaging Comprising Coated Seal Member
US7744570B2 (en) * 2003-11-18 2010-06-29 Icu Medical, Inc. Infusion set

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2605765A (en) * 1947-06-05 1952-08-05 Kollsman Paul Automatic syringe
US3406686A (en) 1965-01-15 1968-10-22 Becton Dickinson Co Prefilled syringe
US4201207A (en) 1973-03-26 1980-05-06 Alza Corporation Bladder for liquid dispenser
DE2552446C3 (en) 1975-03-26 1980-03-13 Siemens Ag, 1000 Berlin Und 8000 Muenchen
DE2513467C3 (en) * 1975-03-26 1979-10-31 Siemens Ag, 1000 Berlin Und 8000 Muenchen
US4140117A (en) 1975-05-12 1979-02-20 Alza Corporation Cartridge for liquid infusion apparatus
US4340048A (en) * 1981-03-28 1982-07-20 Alza Corporation Self-driven hypodermic injector
US4468221A (en) 1981-04-10 1984-08-28 Parker-Hannifin Corporation Medication infusion pump
US4552561A (en) * 1982-12-23 1985-11-12 Alza Corporation Body mounted pump housing and pump assembly employing the same
US4562751A (en) * 1984-01-06 1986-01-07 Nason Clyde K Solenoid drive apparatus for an external infusion pump
US4685903A (en) * 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
US4811845A (en) * 1987-10-06 1989-03-14 Baggett Jobeth Medication compliance packaging system and procedure
US4898582A (en) 1988-08-09 1990-02-06 Pharmetrix Corporation Portable infusion device assembly
US5716343A (en) 1989-06-16 1998-02-10 Science Incorporated Fluid delivery apparatus
US5169390A (en) * 1990-05-21 1992-12-08 Athayde Amulya L Osmotic infusion device
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5256157A (en) 1991-01-31 1993-10-26 Baxter International Inc. Automated infusion pump with replaceable memory cartridges
US5984894A (en) 1991-04-18 1999-11-16 Novo Nordisk A/S Infuser
DE4120267A1 (en) 1991-06-19 1992-12-24 Bader & Partner Medizintechnik A method for operating a device for dispensing a liquid substance medical treatment to a body to be treated and apparatus for performing the method
US6251098B1 (en) * 1992-01-24 2001-06-26 I-Flow, Corp. Fluid container for use with platen pump
US5257980A (en) 1993-04-05 1993-11-02 Minimed Technologies, Ltd. Subcutaneous injection set with crimp-free soft cannula
US5997501A (en) 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
JPH10508518A (en) 1994-11-04 1998-08-25 イーラン・メディカル・テクノロジーズ・リミテッド Liquid is regulated by analyte dispensing device and analyte monitoring
US5568806A (en) * 1995-02-16 1996-10-29 Minimed Inc. Transcutaneous sensor insertion set
US5487738A (en) * 1995-03-31 1996-01-30 Sciulli; Eugene B. Apparatus for drawing fluids into a hypodermic syringe
US5665065A (en) * 1995-05-26 1997-09-09 Minimed Inc. Medication infusion device with blood glucose data input
CA2151407A1 (en) * 1995-06-09 1996-12-10 Duncan Newman Injection device
US5814020A (en) * 1995-09-11 1998-09-29 Elan Medical Technlogies Limited Medicament delivery device
US5858001A (en) * 1995-12-11 1999-01-12 Elan Medical Technologies Limited Cartridge-based drug delivery device
US5910138A (en) * 1996-05-13 1999-06-08 B. Braun Medical, Inc. Flexible medical container with selectively enlargeable compartments and method for making same
WO1998001173A1 (en) * 1996-07-05 1998-01-15 Novo Nordisk A/S Flexible piston rod
DE19802367C1 (en) 1997-02-19 1999-09-23 Hahn Schickard Ges Mikrodosiervorrichtungsarray and methods of operating the same
US6500150B1 (en) * 1997-06-16 2002-12-31 Elan Pharma International Limited Pre-filled drug-delivery device and method of manufacture and assembly of same
US6200293B1 (en) 1997-08-27 2001-03-13 Science Incorporated Fluid delivery device with temperature controlled energy source
US5961492A (en) 1997-08-27 1999-10-05 Science Incorporated Fluid delivery device with temperature controlled energy source
US6039718A (en) * 1998-01-20 2000-03-21 Bracco Research Usa Multiple use universal connector
US5896989A (en) 1998-02-20 1999-04-27 Bracco Research Usa Flexible medical container packaging
JP4469504B2 (en) 1998-10-08 2010-05-26 メドトロニック ミニメド インコーポレイテッド Remote plasma monitor system
US6248093B1 (en) 1998-10-29 2001-06-19 Minimed Inc. Compact pump drive system
US6800071B1 (en) 1998-10-29 2004-10-05 Medtronic Minimed, Inc. Fluid reservoir piston
JP2002529204A (en) * 1998-11-13 2002-09-10 エラン・フアルマ・インターナシヨナル・リミテツド System and method for feeding chemicals
US6290678B1 (en) * 1999-06-01 2001-09-18 A. Susan Aydelotte High contrast syringe
WO2001058506A3 (en) 2000-02-10 2002-02-28 Zvi Nitzan Drug delivery device and method
US6485471B1 (en) 2000-03-03 2002-11-26 Roche Diagnostics Corporation Bellowed fluid delivery apparatus
JP2001286569A (en) * 2000-04-05 2001-10-16 Polytronics Ltd Endermism device
WO2001081640A1 (en) 2000-04-21 2001-11-01 Nippon Steel Corporation Steel plate having excellent burring workability together with high fatigue strength, and method for producing the same
DE60135042D1 (en) 2000-11-09 2008-09-04 Insulet Corp Device for transcutaneous delivery of drugs
WO2002041999A1 (en) 2000-11-24 2002-05-30 Novo Nordisk A/S Decondenser unit
US6939324B2 (en) * 2000-11-30 2005-09-06 Biovalve Technologies, Inc. Fluid delivery and measurement systems and methods
EP1390089B1 (en) 2001-05-18 2007-01-24 Deka Products Limited Partnership Infusion set for a fluid pump
WO2003026726A1 (en) 2001-09-26 2003-04-03 Novo Nordisk A/S Modular drug delivery system
US6582752B2 (en) 2001-11-02 2003-06-24 Nestec, Ltd Methods and compositions for a gender specific diet for puppies
US7041082B2 (en) 2002-02-28 2006-05-09 Smiths Medical Md, Inc. Syringe pump control systems and methods
JP4691445B2 (en) 2002-07-22 2011-06-01 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company Patch-like injection device
US20040068230A1 (en) * 2002-07-24 2004-04-08 Medtronic Minimed, Inc. System for providing blood glucose measurements to an infusion device
US20040059316A1 (en) * 2002-07-31 2004-03-25 Smedegaard Jorgen K. Medical delivery device
EP1396275A1 (en) 2002-09-09 2004-03-10 Novo Nordisk A/S Visual indicator means for delivery device
US20040122353A1 (en) * 2002-12-19 2004-06-24 Medtronic Minimed, Inc. Relay device for transferring information between a sensor system and a fluid delivery system
JP2006511263A (en) 2002-12-23 2006-04-06 エム2・メディカル・アクティーゼルスカブM 2 Medical A/S Disposable wearable insulin dosing device, a method of operating a combination of the device and programming controllers, and the device
DE10327254B4 (en) 2003-06-17 2010-01-28 Disetronic Licensing Ag Modular infusion pump
DE602004005597T2 (en) 2003-07-08 2008-02-14 Novo Nordisk A/S Portable drug delivery device having an encapsulated needle
EP1502613A1 (en) 2003-08-01 2005-02-02 Novo Nordisk A/S Needle device with retraction means
US20050065760A1 (en) * 2003-09-23 2005-03-24 Robert Murtfeldt Method for advising patients concerning doses of insulin
EP1682203B1 (en) 2003-10-23 2010-01-06 Novo Nordisk A/S Medical injection device mountable to the skin
JP4658951B2 (en) 2003-10-21 2011-03-23 ノボ・ノルデイスク・エー/エス Medical devices that can be attached to the skin
EP1527792A1 (en) 2003-10-27 2005-05-04 Novo Nordisk A/S Medical injection device mountable to the skin
WO2005072795A3 (en) 2004-01-29 2005-09-09 M2 Medical As Disposable medicine dispensing device
US20050177108A1 (en) 2004-02-10 2005-08-11 Animas Corporation External infusion device having a casing with multiple cross-vented hermetically-sealed housings
US20050277884A1 (en) 2004-05-26 2005-12-15 Kriesel Marshall S Fluid delivery apparatus with bellows reservoir
CA2891057A1 (en) 2004-11-22 2006-06-01 Kaleo, Inc. Devices, systems, and methods for medicament delivery

Patent Citations (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US401678A (en) * 1889-04-16 Car for live stock
US6241704B1 (en) * 1901-11-22 2001-06-05 Sims Deltec, Inc. Drug pump systems and methods
US2980032A (en) * 1959-02-27 1961-04-18 Brown Engine Products Inc Fuel pump
US4245634A (en) * 1975-01-22 1981-01-20 Hospital For Sick Children Artificial beta cell
US4137020A (en) * 1976-12-26 1979-01-30 Nippondenso Co., Ltd. Diaphragm type air pump
US4262824A (en) * 1978-02-17 1981-04-21 Baxter Travenol Laboratories, Inc. Low-current E-frame electronic magnet with a permanent magnet armature for an I. V. valving controller
US4370305A (en) * 1979-07-23 1983-01-25 Hoelzle & Chelius Kg Device for the sterilization of fluid substances
US4399824A (en) * 1981-10-05 1983-08-23 Air-Shields, Inc. Apparatus for detecting probe dislodgement
US4378015A (en) * 1981-12-21 1983-03-29 Wardlaw Stephen C Automatic injecting syringe
US4529401A (en) * 1982-01-11 1985-07-16 Cardiac Pacemakers, Inc. Ambulatory infusion pump having programmable parameters
US4753651A (en) * 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
US4519792A (en) * 1982-12-06 1985-05-28 Abbott Laboratories Infusion pump system
US4645491A (en) * 1984-03-09 1987-02-24 David Evans Surgical needle
US4657490A (en) * 1985-03-27 1987-04-14 Quest Medical, Inc. Infusion pump with disposable cassette
US4734902A (en) * 1985-05-08 1988-03-29 James T. Dennis Record player
US4755173A (en) * 1986-02-25 1988-07-05 Pacesetter Infusion, Ltd. Soft cannula subcutaneous injection set
US5211201A (en) * 1986-03-04 1993-05-18 Deka Products Limited Partnership Intravenous fluid delivery system with air elimination
US4994078A (en) * 1988-02-17 1991-02-19 Jarvik Robert K Intraventricular artificial hearts and methods of their surgical implantation and use
US4894054A (en) * 1988-06-20 1990-01-16 Miskinyar Shir A Preloaded automatic disposable syringe
US5527287A (en) * 1988-06-20 1996-06-18 Miskinyar; Shir A. Preloaded automatic disposable syringe
US4928528A (en) * 1988-07-25 1990-05-29 Cordis Corporation Arterial/venous simulator
US5008110A (en) * 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5224843A (en) * 1989-06-14 1993-07-06 Westonbridge International Ltd. Two valve micropump with improved outlet
US5122116A (en) * 1990-04-24 1992-06-16 Science Incorporated Closed drug delivery system
US5122201A (en) * 1991-11-19 1992-06-16 International Business Machines Corporation Water-soluble solder flux
US6060319A (en) * 1991-12-13 2000-05-09 Diametrics Medical. Inc. Temperature stabilized fluid reference system
US5609572A (en) * 1992-11-23 1997-03-11 Lang; Volker Cassette infusion system
US5336052A (en) * 1993-04-28 1994-08-09 Abel Pumpen Gmbh & Co. Kg Viscous material pump
US5391950A (en) * 1993-06-24 1995-02-21 Unisys Corporation Circuit to eliminate signal chatter in the output of a fiber-optic receiver
US5485917A (en) * 1993-12-06 1996-01-23 Ethicon-Endo-Surgery Quick release package for surgical instrument
US5390671A (en) * 1994-03-15 1995-02-21 Minimed Inc. Transcutaneous sensor insertion set
US5514095A (en) * 1994-04-04 1996-05-07 Haemonetics Corporation Apparatus for heating, filtering and eliminating gas from biological fluids
US5482473A (en) * 1994-05-09 1996-01-09 Minimed Inc. Flex circuit connector
US5494415A (en) * 1994-09-12 1996-02-27 Morita; Yoshimitsu Magnetically-driven pump
US5931814A (en) * 1994-10-28 1999-08-03 Hoffmann-La Roche Inc. Dermally affixed injection device
US5647853A (en) * 1995-03-03 1997-07-15 Minimed Inc. Rapid response occlusion detector for a medication infusion pump
US5925017A (en) * 1995-10-11 1999-07-20 Science Incorporated Fluid delivery device with bolus injection site
US5860952A (en) * 1996-01-11 1999-01-19 C. R. Bard, Inc. Corporeal access tube assembly and method
US5941611A (en) * 1996-01-19 1999-08-24 Hydraulik-Ring Antriebs- Und Steuerungstechnik Gmbh Actuating device for brakes of a vehicle, preferably a motor vehicle
US5720391A (en) * 1996-03-29 1998-02-24 St. Jude Medical, Inc. Packaging and holder for heart valve prosthesis
US5776109A (en) * 1996-08-23 1998-07-07 Urrutia; Hector Drip chamber for intravenous fluid delivery system
US5928194A (en) * 1997-04-07 1999-07-27 Maget; Henri J. R. Self-contained liquid microdispenser
US20030135159A1 (en) * 1997-05-06 2003-07-17 Elan Pharma International Limited Drug delivery device
US5913856A (en) * 1997-05-19 1999-06-22 Irvine Biomedical, Inc. Catheter system having a porous shaft and fluid irrigation capabilities
US6716192B1 (en) * 1997-09-30 2004-04-06 Charles F. Schroeder Medical needle having a visibly marked tip
US6270478B1 (en) * 1997-10-23 2001-08-07 Mernoee Morton Infusion pump system and an infusion pump unit
US6045534A (en) * 1997-10-27 2000-04-04 Sarcos, Inc. Disposable fluid injection module
US6083196A (en) * 1997-12-11 2000-07-04 Alza Corporation Device for enhancing transdermal agent flux
US6074369A (en) * 1998-02-20 2000-06-13 Becton, Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US20050171513A1 (en) * 1998-08-18 2005-08-04 Medtronic Minimed Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US6551276B1 (en) * 1998-08-18 2003-04-22 Medtronic Minimed, Inc. External infusion device with remote programming bolus estimator and/or vibration alarm capabilities
US6555986B2 (en) * 1998-10-29 2003-04-29 Minimed Inc. Method and apparatus for detection of occlusions
US6088619A (en) * 1999-02-26 2000-07-11 Implex Aktiengesellschaft Hearing Technology Device and method for aiding the positioning of an external part relative to an implantable part of a charging system for an implantable medical device
US6099512A (en) * 1999-05-10 2000-08-08 Urrutia; Hector Limited flow rate drip chamber for intravenous fluid delivery system
US6558351B1 (en) * 1999-06-03 2003-05-06 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
US6554791B1 (en) * 1999-09-29 2003-04-29 Smisson-Cartledge Biomedical, Llc Rapid infusion system
US6358731B1 (en) * 1999-10-20 2002-03-19 Wei K. Hsu Sterilizable cultivation system with separately attachable microfiltration membrane
US20030065308A1 (en) * 2000-01-21 2003-04-03 Lebel Ronald J. Ambulatory medical apparatus with hand held communication device
US20020040083A1 (en) * 2000-01-26 2002-04-04 Tetsuo Kuwaki Flame-retardant and flame-retarding resin composition
US20030009131A1 (en) * 2000-03-13 2003-01-09 Medtronic Minimed, Inc. Leak detection system and method of using the same
US20050006309A1 (en) * 2000-06-21 2005-01-13 Carlo Effenhauser Pump for low flow rates
US20020055711A1 (en) * 2000-06-30 2002-05-09 Gilad Lavi Needle device and method thereof
US6589229B1 (en) * 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
US6740059B2 (en) * 2000-09-08 2004-05-25 Insulet Corporation Devices, systems and methods for patient infusion
US20020040208A1 (en) * 2000-10-04 2002-04-04 Flaherty J. Christopher Data collection assembly for patient infusion system
US20020064468A1 (en) * 2000-11-28 2002-05-30 Duncan Wade Diaphragm for a diaphragm pump
US7052483B2 (en) * 2000-12-19 2006-05-30 Animas Corporation Transcutaneous inserter for low-profile infusion sets
US20040051674A1 (en) * 2000-12-19 2004-03-18 Claus Mahringer Communication terminal with antenna
US6749587B2 (en) * 2001-02-22 2004-06-15 Insulet Corporation Modular infusion device and method
US20040158207A1 (en) * 2001-04-06 2004-08-12 Marcel Hunn Infusion set
US20030009133A1 (en) * 2001-04-13 2003-01-09 Kirk Ramey Drive system for an infusion pump
US20030029501A1 (en) * 2001-06-13 2003-02-13 Williamson Mark E. Vacuum demand valve
US20030088238A1 (en) * 2001-09-26 2003-05-08 Poulsen Jens Ulrik Modular drug delivery system
US20030060781A1 (en) * 2001-09-27 2003-03-27 Mogensen Lasse Wesseltoft Injector device for placing a subcutaneous infusion set
US20030069546A1 (en) * 2001-10-04 2003-04-10 Sandstrom Jeffrey D. Right angle safety needle
US20030073952A1 (en) * 2001-10-12 2003-04-17 Flaherty J. Christopher Laminated patient infusion device
US20030114797A1 (en) * 2001-12-17 2003-06-19 Vaillancourt Vincent L. Safety needle with collapsible sheath
US20040087240A1 (en) * 2002-01-31 2004-05-06 Zhizhang Chen Method of manufacturing an emitter
US6878136B2 (en) * 2002-02-28 2005-04-12 Medical Product Specialists Huber needle with anti-rebound safety mechanism
US20040127844A1 (en) * 2002-03-01 2004-07-01 Flaherty J. Christopher Flow condition sensor assembly for patient infusion device
US20040098068A1 (en) * 2002-06-28 2004-05-20 Rafael Carbunaru Chair pad charging and communication system for a battery-powered microstimulator
US20040116905A1 (en) * 2002-09-09 2004-06-17 Pedersen Per Elgard Flow restrictor with safety feature
US20040115068A1 (en) * 2002-09-27 2004-06-17 Steffen Hansen Membrane pump with stretchable pump membrane
US20040162521A1 (en) * 2002-10-07 2004-08-19 Henrik Bengtsson Needle device comprising a plurality of needles
US20060015063A1 (en) * 2002-11-29 2006-01-19 Buetikofer Markus Catheter head with closeable seal element
US7070580B2 (en) * 2003-04-01 2006-07-04 Unomedical A/S Infusion device and an adhesive sheet material and a release liner
US20050022274A1 (en) * 2003-04-18 2005-01-27 Robert Campbell User interface for infusion pump remote controller and method of using the same
US20080009805A1 (en) * 2003-05-08 2008-01-10 Novo Nordisk A/S Integrated package
US20060142698A1 (en) * 2003-05-08 2006-06-29 Novo Nordisk A/S Internal needle inserter
US20050077225A1 (en) * 2003-10-10 2005-04-14 Usher Kathryn M. Apparatus and method for removing gasses from a liquid
US20050101933A1 (en) * 2003-11-10 2005-05-12 James Marrs Subcutaneous infusion device and method
US7744570B2 (en) * 2003-11-18 2010-06-29 Icu Medical, Inc. Infusion set
US20070104596A1 (en) * 2004-03-30 2007-05-10 Novo Nordisk A/S Actuator system comprising lever mechanism
US20070112301A1 (en) * 2004-03-30 2007-05-17 Novo Nordisk A/S Actuator system comprising detector means
US20060020300A1 (en) * 2004-06-09 2006-01-26 David Nghiem Implantable medical device package antenna
US20060017576A1 (en) * 2004-07-20 2006-01-26 Medtronic, Inc. Alert system and method for an implantable medical device
US20070073228A1 (en) * 2005-09-26 2007-03-29 Morten Mernoe Dispensing fluid from an infusion pump system
US20090163874A1 (en) * 2006-04-26 2009-06-25 Novo Nordisk A/S Skin-Mountable Device in Packaging Comprising Coated Seal Member

Cited By (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7981085B2 (en) 2003-05-08 2011-07-19 Novo Nordisk A/S Internal needle inserter
US20060142698A1 (en) * 2003-05-08 2006-06-29 Novo Nordisk A/S Internal needle inserter
US20060095014A1 (en) * 2003-05-08 2006-05-04 Novo Nordisk A/S External inserter for transcutaneous device
US20110060289A1 (en) * 2003-05-08 2011-03-10 Novo Nordisk A/S Integrated package
US8029469B2 (en) 2003-05-08 2011-10-04 Novo Nordisk A/S External inserter for transcutaneous device
US8740851B2 (en) 2003-05-08 2014-06-03 Novo Nordisk A/S Integrated package
US20070049865A1 (en) * 2003-08-01 2007-03-01 Novo Nordisk A/S Retraction means for transcutaneous device
US7955297B2 (en) * 2003-08-01 2011-06-07 Novo Nordisk A/S Retraction means for transcutaneous device
US7744570B2 (en) 2003-11-18 2010-06-29 Icu Medical, Inc. Infusion set
US20090112166A1 (en) * 2003-11-18 2009-04-30 Icu Medical, Inc. Infusion set
US20110166524A1 (en) * 2004-03-30 2011-07-07 Novo Nordisk A/S Actuator System Comprising Lever Mechanism
US7922462B2 (en) 2004-03-30 2011-04-12 Novo Nordisk A/S Actuator system comprising lever mechanism
US20070104596A1 (en) * 2004-03-30 2007-05-10 Novo Nordisk A/S Actuator system comprising lever mechanism
US20090014320A1 (en) * 2004-06-14 2009-01-15 Massachusetts Institute Of Technology Electrochemical actuator
US8604664B2 (en) 2004-06-14 2013-12-10 Massachusetts Institute Of Technology Electrochemical actuator
US7923895B2 (en) 2004-06-14 2011-04-12 Massachusetts Institute Of Technology Electrochemical methods, devices, and structures
US8310130B2 (en) 2004-06-14 2012-11-13 Massachusetts Institute Of Technology Electrochemical methods, devices, and structures
US20110098643A1 (en) * 2004-06-14 2011-04-28 Massachusetts Institute Of Technology Electrochemical actuator
US7872396B2 (en) 2004-06-14 2011-01-18 Massachusetts Institute Of Technology Electrochemical actuator
US8093781B2 (en) 2004-06-14 2012-01-10 Massachusetts Institute Of Technology Electrochemical actuator
US7999435B2 (en) 2004-06-14 2011-08-16 Massachusetts Institute Of Technology Electrochemical actuator
US20080157713A1 (en) * 2004-06-14 2008-07-03 Massachusetts Institute Of Technology Electrochemical methods, devices, and structures
US7994686B2 (en) 2004-06-14 2011-08-09 Massachusetts Institute Of Technology Electrochemical methods, devices, and structures
US8247946B2 (en) 2004-06-14 2012-08-21 Massachusetts Institute Of Technology Electrochemical actuator
US8378552B2 (en) 2004-06-14 2013-02-19 Massachusetts Institute Of Technology Electrochemical actuator
US20080215006A1 (en) * 2004-09-22 2008-09-04 Novo Nordisk A/S Medical Device with Transcutaneous Cannula Device
US20090012472A1 (en) * 2004-09-22 2009-01-08 Novo Nordisk A/S Medical Device with Cannula Inserter
US20090048563A1 (en) * 2004-12-06 2009-02-19 Novo Nordisk A/S Ventilated Skin Mountable Device
US20090076451A1 (en) * 2005-01-24 2009-03-19 Nova Nordisk A/S Medical Device with Protected Transcutaneous Device
US8167841B2 (en) 2005-01-24 2012-05-01 Novo Nordisk A/S Transcutaneous device assembly
US7628590B2 (en) * 2005-02-16 2009-12-08 Sterling Investments Lc Method and apparatus for reducing free flow risk
US20060182637A1 (en) * 2005-02-16 2006-08-17 Sarcos Investments Lc. Method and apparatus for reducing free flow risk
US20080167641A1 (en) * 2005-05-13 2008-07-10 Novo Nordisk A/S Medical Device Adapted To Detect Disengagement Of A Transcutaneous Device
US8657788B2 (en) 2006-02-07 2014-02-25 Tecpharma Licensing Ag Infusion set
US20070185441A1 (en) * 2006-02-07 2007-08-09 Fangrow Thomas F Jr Infusion set
US20070185455A1 (en) * 2006-02-07 2007-08-09 Fangrow Thomas F Jr Infusion set
US7931615B2 (en) * 2006-02-07 2011-04-26 Icu Medical, Inc. Infusion set
US8956330B2 (en) 2006-02-07 2015-02-17 Techpharma Licensing Ag Infusion set
US7892216B2 (en) 2006-02-07 2011-02-22 Icu Medical, Inc. Infusion set
US20090069868A1 (en) * 2006-03-11 2009-03-12 Henrik Bengtsson Secure Pairing of Electronic Devices using Dual Means of Communication
US9173992B2 (en) 2006-03-13 2015-11-03 Novo Nordisk A/S Secure pairing of electronic devices using dual means of communication
US20090062778A1 (en) * 2006-03-13 2009-03-05 Novo Nordisk A/S Medical System Comprising Dual-Purpose Communication Means
US20090163874A1 (en) * 2006-04-26 2009-06-25 Novo Nordisk A/S Skin-Mountable Device in Packaging Comprising Coated Seal Member
US20090192471A1 (en) * 2006-05-31 2009-07-30 Calibra Medical, Inc. Disposable infusion device with locked cannula
US20090254041A1 (en) * 2006-06-06 2009-10-08 Krag Christian Roege Assembly Comprising Skin-Mountable Device and Packaging Therefore
US9399094B2 (en) 2006-06-06 2016-07-26 Novo Nordisk A/S Assembly comprising skin-mountable device and packaging therefore
US20100222765A1 (en) * 2007-01-24 2010-09-02 Smiths Medical Asd, Inc. Correction factor testing using frequent blood glucose input
US8208984B2 (en) 2007-01-24 2012-06-26 Smiths Medical Asd, Inc. Correction factor testing using frequent blood glucose input
US20100063448A1 (en) * 2007-03-06 2010-03-11 Novo Nordisk A/S Pump assembly comprising actuator system
US20080228056A1 (en) * 2007-03-13 2008-09-18 Michael Blomquist Basal rate testing using frequent blood glucose input
WO2008142636A2 (en) * 2007-05-22 2008-11-27 Koninklijke Philips Electronics N.V. Wearable drug delivery device
WO2008142640A1 (en) * 2007-05-22 2008-11-27 Koninklijke Philips Electronics N.V. Wearable drug delivery device
WO2008142636A3 (en) * 2007-05-22 2009-05-07 Koninkl Philips Electronics Nv Wearable drug delivery device
US20100312221A1 (en) * 2007-05-22 2010-12-09 Koninklijke Philips Electronics N.V. Wearable drug delivery device
US20100274751A1 (en) * 2007-05-24 2010-10-28 Smith Medical Asd, Inc. Expert system for insulin pump therapy
US8219222B2 (en) 2007-05-24 2012-07-10 Smiths Medical Asd, Inc. Expert system for pump therapy
US8221345B2 (en) 2007-05-30 2012-07-17 Smiths Medical Asd, Inc. Insulin pump based expert system
US20080300534A1 (en) * 2007-05-30 2008-12-04 Michael Blomquist Insulin pump based expert system
US9833177B2 (en) 2007-05-30 2017-12-05 Tandem Diabetes Care, Inc. Insulin pump based expert system
US7828771B2 (en) 2007-07-26 2010-11-09 Entra Pharmaceuticals, Inc. Systems and methods for delivering drugs
US20110098676A1 (en) * 2007-07-26 2011-04-28 Yet-Ming Chiang Systems and methods for delivering drugs
US20090028824A1 (en) * 2007-07-26 2009-01-29 Entra Pharmaceuticals, Inc. Systems and methods for delivering drugs
US9782545B2 (en) 2007-10-02 2017-10-10 Medimop Medical Projects Ltd. External drug pump
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
US9173997B2 (en) 2007-10-02 2015-11-03 Medimop Medical Projects Ltd. External drug pump
US9861759B2 (en) 2007-10-02 2018-01-09 Medimop Medical Projects Ltd. External drug pump
US9656019B2 (en) 2007-10-02 2017-05-23 Medimop Medical Projects Ltd. Apparatuses for securing components of a drug delivery system during transport and methods of using same
US8557179B2 (en) 2007-10-31 2013-10-15 Novo Nordisk A/S Non-porous material as sterilization barrier
US20110008206A1 (en) * 2007-10-31 2011-01-13 Novo Nordisk A/S Non-Porous Material as Sterilization Barrier
US20110040251A1 (en) * 2008-01-09 2011-02-17 Michael Blomquist Infusion pump with add-on modules
US8414523B2 (en) * 2008-01-09 2013-04-09 Tandem Diabetes Care, Inc. Infusion pump with add-on modules
US9889250B2 (en) 2008-01-09 2018-02-13 Tandem Diabetes Care, Inc. Infusion pump with temperature monitoring
US8840582B2 (en) 2008-01-09 2014-09-23 Tandem Diabetes Care, Inc. Infusion pump with activity monitoring
US20160310664A1 (en) * 2008-08-18 2016-10-27 Calibra Medical, Inc. Drug infusion system with reusable and disposable components
US20100049128A1 (en) * 2008-08-18 2010-02-25 Calibra Medical, Inc. Drug infusion system with reusable and disposable components
US8152779B2 (en) 2008-12-30 2012-04-10 Medimop Medical Projects Ltd. Needle assembly for drug pump
US9782536B2 (en) 2009-01-12 2017-10-10 Becton, Dickinson And Company Infusion set and/or patch pump having at least one of an in-dwelling rigid catheter with flexible features and/or a flexible catheter attachment
US20100217233A1 (en) * 2009-02-20 2010-08-26 Ranft Elizabeth A Method and device to anesthetize an area
US8996089B2 (en) 2009-06-30 2015-03-31 Arkray, Inc. Continuous analysis device and sample component control system
US9764083B1 (en) 2009-07-23 2017-09-19 Becton, Dickinson And Company Medical device having capacitive coupling communication and energy harvesting
US8939928B2 (en) 2009-07-23 2015-01-27 Becton, Dickinson And Company Medical device having capacitive coupling communication and energy harvesting
US20110022025A1 (en) * 2009-07-23 2011-01-27 Becton, Dickinson And Company Medical device having capacitive coupling communication and energy harvesting
US9375529B2 (en) 2009-09-02 2016-06-28 Becton, Dickinson And Company Extended use medical device
US20110054285A1 (en) * 2009-09-02 2011-03-03 Becton, Dickinson And Company Flexible and Conformal Patch Pump
US20110054390A1 (en) * 2009-09-02 2011-03-03 Becton, Dickinson And Company Extended Use Medical Device
US8157769B2 (en) 2009-09-15 2012-04-17 Medimop Medical Projects Ltd. Cartridge insertion assembly for drug delivery system
US8465455B2 (en) 2009-09-15 2013-06-18 Medimop Medical Projects Ltd. Cartridge insertion assembly
US9572926B2 (en) 2009-09-15 2017-02-21 Medimop Medical Projects Ltd. Cartridge insertion assembly
US8961469B2 (en) 2009-12-16 2015-02-24 Becton, Dickinson And Company Self-injection device
US9579461B2 (en) 2009-12-16 2017-02-28 Becton, Dickinson And Company Self-injection device
US9717850B2 (en) 2009-12-16 2017-08-01 Becton, Dickinson And Company Self-injection device
US9919097B2 (en) 2009-12-16 2018-03-20 Becton, Dickinson And Company Self-injection device
US9833562B2 (en) 2009-12-16 2017-12-05 Becton, Dickinson And Company Self-injection device
US9555187B2 (en) 2009-12-16 2017-01-31 Becton, Dickinson And Company Self-injection device
US8348898B2 (en) 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
US8915882B2 (en) 2010-01-19 2014-12-23 Medimop Medical Projects Ltd. Needle assembly for drug pump
US7967795B1 (en) 2010-01-19 2011-06-28 Lamodel Ltd. Cartridge interface assembly with driving plunger
US9259532B2 (en) 2010-01-19 2016-02-16 Medimop Medical Projects Ltd. Cartridge interface assembly
US9492610B2 (en) 2010-01-19 2016-11-15 MEDIMOP Projects Ltd. Needle assembly for drug pump
US9764092B2 (en) 2010-01-19 2017-09-19 Medimop Medical Projects Ltd. Needle assembly for drug pump
US9149575B2 (en) 2010-01-19 2015-10-06 Medimop Medical Projects Ltd. Needle assembly for drug pump
US20110178463A1 (en) * 2010-01-19 2011-07-21 Oz Cabiri Cartridge interface assembly with driving plunger
US9522234B2 (en) 2010-01-19 2016-12-20 Medimop Medical Projects Ltd. Needle assembly for drug pump
US8337457B2 (en) 2010-05-05 2012-12-25 Springleaf Therapeutics, Inc. Systems and methods for delivering a therapeutic agent
US9452261B2 (en) 2010-05-10 2016-09-27 Medimop Medical Projects Ltd. Low volume accurate injector
US9675752B2 (en) 2010-09-02 2017-06-13 Becton, Dickinson And Company Self-injection device having needle cover with activation preventer
US8945071B2 (en) 2010-09-02 2015-02-03 Becton, Dickinson And Company Self-injection device having needle cover with activation preventer
US8430849B2 (en) 2010-09-24 2013-04-30 Perqflo, Llc Infusion pumps and plunger pusher position-responsive cartridge lock for infusion pumps
US9320849B2 (en) 2010-09-24 2016-04-26 Perqflo, Llc Infusion pumps
US9750875B2 (en) 2010-09-24 2017-09-05 Perqflo, Llc Infusion pumps
US9381300B2 (en) 2010-09-24 2016-07-05 Perqflo, Llc Infusion pumps
US9308320B2 (en) 2010-09-24 2016-04-12 Perqflo, Llc Infusion pumps
US9498573B2 (en) 2010-09-24 2016-11-22 Perqflo, Llc Infusion pumps
US9216249B2 (en) 2010-09-24 2015-12-22 Perqflo, Llc Infusion pumps
US8915879B2 (en) 2010-09-24 2014-12-23 Perqflo, Llc Infusion pumps
US8777901B2 (en) 2010-09-24 2014-07-15 Perqflo, Llc Infusion pumps
US8905972B2 (en) 2010-11-20 2014-12-09 Perqflo, Llc Infusion pumps
US8814831B2 (en) 2010-11-30 2014-08-26 Becton, Dickinson And Company Ballistic microneedle infusion device
US9950109B2 (en) 2010-11-30 2018-04-24 Becton, Dickinson And Company Slide-activated angled inserter and cantilevered ballistic insertion for intradermal drug infusion
US9844635B2 (en) 2010-11-30 2017-12-19 Becton, Dickinson And Company Adjustable height needle infusion device
US8795230B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Adjustable height needle infusion device
US9480792B2 (en) 2010-11-30 2016-11-01 Becton, Dickinson And Company Ballistic microneedle infusion device
US8368285B2 (en) 2010-12-17 2013-02-05 Massachusette Institute Of Technology Electrochemical actuators
US9795361B2 (en) 2011-03-02 2017-10-24 General Electric Company Device for assisting with the handling of an instrument or tool
USD747799S1 (en) 2011-03-22 2016-01-19 Medimop Medical Projects Ltd. Cartridge
USD702834S1 (en) 2011-03-22 2014-04-15 Medimop Medical Projects Ltd. Cartridge for use in injection device
US9623173B2 (en) 2012-03-05 2017-04-18 Becton, Dickinson And Company Wireless communication for on-body medical devices
US9878091B2 (en) 2012-03-26 2018-01-30 Medimop Medical Projects Ltd. Motion activated septum puncturing drug delivery device
US9393365B2 (en) 2012-03-26 2016-07-19 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US9511190B2 (en) 2012-03-26 2016-12-06 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US9463280B2 (en) 2012-03-26 2016-10-11 Medimop Medical Projects Ltd. Motion activated septum puncturing drug delivery device
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
US9011164B2 (en) 2013-04-30 2015-04-21 Medimop Medical Projects Ltd. Clip contact for easy installation of printed circuit board PCB
US9166313B2 (en) 2013-04-30 2015-10-20 Medimop Medical Projects Power supply contact for installation of printed circuit board
US9889256B2 (en) 2013-05-03 2018-02-13 Medimop Medical Projects Ltd. Sensing a status of an infuser based on sensing motor control and power input
US9416775B2 (en) 2014-07-02 2016-08-16 Becton, Dickinson And Company Internal cam metering pump
US9669160B2 (en) 2014-07-30 2017-06-06 Tandem Diabetes Care, Inc. Temporary suspension for closed-loop medicament therapy
US9795534B2 (en) 2015-03-04 2017-10-24 Medimop Medical Projects Ltd. Compliant coupling assembly for cartridge coupling of a drug delivery device
US9744297B2 (en) 2015-04-10 2017-08-29 Medimop Medical Projects Ltd. Needle cannula position as an input to operational control of an injection device
USD805189S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD804650S1 (en) 2016-09-26 2017-12-05 West Pharmaceutical Services, Inc. Injector device
USD805187S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD804019S1 (en) 2016-09-26 2017-11-28 West Pharmaceutical Services, Inc. Injector device
USD805186S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD805188S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD805190S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD807499S1 (en) 2016-10-26 2018-01-09 West Pharmaceutical Services, Inc. Injector device
USD808011S1 (en) 2016-10-26 2018-01-16 West Pharmaceutical Services, Inc. Injector device
USD806863S1 (en) 2016-10-26 2018-01-02 West Pharmaceutical Services, Inc. Injector device
USD806234S1 (en) 2016-10-26 2017-12-26 West Pharmaceutical Services, Inc. Injector device
USD805633S1 (en) 2016-10-26 2017-12-19 West Pharmaceutical Services, Inc. Injector device
USD805632S1 (en) 2016-10-26 2017-12-19 West Pharmaceutical Services, Inc. Injector device
USD806235S1 (en) 2016-10-26 2017-12-26 West Pharmaceutical Services, Inc. Injector device

Also Published As

Publication number Publication date Type
KR20060099520A (en) 2006-09-19 application
US20060264835A1 (en) 2006-11-23 application
US8062253B2 (en) 2011-11-22 grant

Similar Documents

Publication Publication Date Title
US8323250B2 (en) Adhesive patch systems and methods
US7935104B2 (en) Systems and methods for sustained medical infusion and devices related thereto
US6830562B2 (en) Injector device for placing a subcutaneous infusion set
US8025658B2 (en) Adhesive patch systems and methods
US5267964A (en) Fluid control device including automatic valve
US8162923B2 (en) Disposable infusion device with automatic unlocking mechanism
US8465455B2 (en) Cartridge insertion assembly
US6692457B2 (en) Flow condition sensor assembly for patient infusion device
US4687468A (en) Implantable insulin administration device
US20060122577A1 (en) Modular drug delivery system
US20070066955A1 (en) Reservoir device with integrated mounting means
US20030109829A1 (en) Injector device for placing a subcutaneous infusion set
US7455663B2 (en) Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US5785688A (en) Fluid delivery apparatus and method
US20080215035A1 (en) Systems, devices and methods for sustained delivery of a therapeutic fluid
US20030088238A1 (en) Modular drug delivery system
US7128727B2 (en) Components and methods for patient infusion device
US20070049873A1 (en) Impulse chamber for jet delivery device
US5169390A (en) Osmotic infusion device
US20080269680A1 (en) Systems and methods for reservoir filling
EP1341569B1 (en) Transcutaneous delivery means
US20100121306A1 (en) Collapsible reservoir for use with a delivery device
US5672167A (en) Controlled release osmotic pump
US20080255516A1 (en) Apparatus and method for pumping fluid
US20100049128A1 (en) Drug infusion system with reusable and disposable components

Legal Events

Date Code Title Description
AS Assignment

Owner name: NOVO NORDISK A/S, DENMARK

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HANSEN, STEFFEN;LARSEN, BJORN GULLAK;MOLLER, CLAUS SCHMIDT;AND OTHERS;REEL/FRAME:018294/0670;SIGNING DATES FROM 20060618 TO 20060814