US20070010852A1 - Closure devices, related delivery methods, and related methods of use - Google Patents

Closure devices, related delivery methods, and related methods of use Download PDF

Info

Publication number
US20070010852A1
US20070010852A1 US11522157 US52215706A US2007010852A1 US 20070010852 A1 US20070010852 A1 US 20070010852A1 US 11522157 US11522157 US 11522157 US 52215706 A US52215706 A US 52215706A US 2007010852 A1 US2007010852 A1 US 2007010852A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
anchor
method
end
passageway
elongate member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11522157
Inventor
David Blaeser
Jerome Grudem
Scott Olson
Mark Christianson
Scott Hanson
Edward Anderson
Patrick Russo
Dennis Wahr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
St Jude Medical Cardiology Division Inc
Original Assignee
St Jude Medical Cardiology Division Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00592Elastic or resilient implements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00606Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00619Locking means for locking the implement in expanded state
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00623Introducing or retrieving devices therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers

Abstract

A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the passageway and connect the left and right atrial anchors. The right atrial anchor preferably includes a plurality of arms and a cover attached to the arms. The left atrial anchor preferably also includes a plurality of arms and preferably-does not include-a-cover. Preferably, the elongate member has a first end fixedly connected to the left atrial anchor and a portion, proximal to the first end, passing through the right atrial anchor. Preferably, the elongate member is flexible.

Description

    DESCRIPTION OF THE INVENTION
  • 1. Field of the Invention
  • This invention relates to devices for closing a passageway in a body, for example a patent foramen ovale in a heart, related methods and devices for delivering such closure devices, and related methods of using such closure devices for sealing the passageway.
  • 2. Background of the Invention
  • FIG. 1 shows a portion of a heart in longitudinal section, with the right atrium (RA), left atrium (LA), right ventricle (RV) and left ventricle (LV) shown. FIG. 1 also shows the septum primum (SP), a flap-like structure, which normally covers the foramen ovale, an opening in the septum secundum (SS) of the heart. In utero, the foramen ovale serves as a physiologic conduit for right-to-left shunting of blood in the fetal heart. After birth, with the establishment of pulmonary circulation, the increased left atrial blood flow and pressure presses the septum primum (SP) against the walls of the septum secundum (SS), covering the foramen ovale and resulting in functional closure of the foramen ovale. This closure is usually followed by anatomical closure of the foramen ovale due to fusion of the septum primum (SP) to the septum secundum (SS).
  • Where anatomical closure of the foramen ovale does not occur, a patent foramen ovale (PFO) is created. A patent foramen ovale is a persistent, usually flap-like opening between the atrial septum primum (SP) and septum secundum (SS) of a heart. A patent foramen ovale results when either partial or no fusion of the septum primum (SP) to the septum secundum (SS) occurs. In the case of partial fusion, a persistent passageway exists between the superior portion of the septum primum (SP) and septum secundum (SS). It is also possible that more than one passageway may exist between the septum primum (SP) and the septum secundum (SS).
  • Studies have shown that a relatively large percentage of adults have a patent foramen ovale (PFO). It is believed that embolism via a PFO may be a cause of a significant number of ischemic strokes, particularly in relatively young patients. It has been estimated that in 50% of cryptogenic strokes, a PFO is present. Patients suffering a cryptogenic stroke or a transient ischemic attack (TIA) in the presence of a PFO often are considered for medical therapy to reduce the risk of a recurrent embolic event.
  • Pharmacological therapy often includes oral anticoagulants or antiplatelet agents. These therapies may lead to certain side effects, including hemorrhaging. If pharmacologic therapy is unsuitable, open heart surgery may be employed to close a PFO with stitches, for example. Like other open surgical treatments, this surgery is highly invasive, risky, requires general anesthesia, and may result in lengthy recuperation.
  • Nonsurgical closure of PFOs is possible with umbrella-like devices developed for percutaneous closure of atrial septal defects (ASD) (a condition where there is not a septum primum (SP)). Many of these conventional devices used for ASDs, however, are technically complex, bulky, and difficult to deploy in a precise location. In addition, such devices may be difficult or impossible to retrieve and/or reposition should initial positioning not be satisfactory. Moreover, these devices are specially designed for ASDs and therefore may not be suitable to close and seal a PFO, particularly because the septum primum (SP) overlaps the septum secundum (SS).
  • SUMMARY OF THE INVENTION
  • In accordance with the invention, methods, tools, and devices for closing a passageway in a body, and more specifically closing a patent foramen ovale (PFO), are provided.
  • According to one aspect of the invention, a device for sealing a passageway in a human body is provided. The device comprises a first anchor adapted to be placed proximate a first end of the passageway, the first anchor including a plurality of first loop structures, each first loop structure having a first end connected to the first anchor and a second free end, a second anchor adapted to be placed proximate a second end of the passageway, and an elongate member adapted to extend through the passageway and connect the first and second anchors, the elongate member having a first end fixedly connected to one of the first and second anchors.
  • According to another aspect of the invention, a device for sealing a passageway in a human body comprises a first anchor adapted to be placed proximate a first end of the passageway, the first anchor including a plurality of first loop structures, each first loop structure having a first end connected to the first anchor and a second free end, a second anchor adapted to be placed proximate a second end of the passageway, and a flexible elongate member adapted to extend through the passageway and connect the first and second anchors, the elongate member capable of moving through the second anchor to vary a length of the elongate member between the first and second anchors.
  • According to a further aspect of the invention, the device for sealing a passageway in a human body comprises a first anchor adapted to be placed proximate a first end of the passageway, the first anchor including a plurality of first loop structures, each first loop structure having a first end connected to the first anchor and a second free end, a second anchor adapted to be placed proximate a second end of the passageway, the second anchor including a plurality of second loop structures, and a flexible elongate member adapted to extend through the passageway and connect the first and second anchors, the elongate member capable of moving through the second anchor to vary a length of the elongate member between the first and second anchors.
  • According to yet another aspect of the invention, a device for sealing a passageway in a human body comprises a first anchor adapted to be placed proximate a first end of the passageway, the first anchor including a plurality of first loop structures, each first loop structure having a first end connected to the first anchor and a second free end, a second anchor adapted to be placed proximate a second end of the passageway, and a flexible elongate member adapted to extend through the passageway and connect the first and second anchors, wherein the first anchor pivots relative to the elongate member and the second anchor pivots relative to the elongate member.
  • According to another aspect of the present invention, a device for sealing a passageway in a human body comprises a first anchor adapted to be placed proximate a first end of the passageway, the first anchor including a plurality of first loop structures, each first loop structure having a first end connected to the first anchor and a second free end, a second anchor adapted to be placed proximate a second end of the passageway, and a flexible elongate member adapted to extend through the passageway and connect the first and second anchors, wherein each of the first and second anchors is collapsible from a deployed state to a collapsed delivery state.
  • According to a further aspect of the present invention, a device for sealing a passageway in a human body comprises a first anchor adapted to be placed proximate a first end of the passageway, the first anchor including a plurality of first loop structures, each loop structure including an outer loop portion and a member connecting portions of outer loop portion, a second anchor adapted to be placed proximate a second end of the passageway, and an elongate member adapted to extend through the passageway and connect the first and second anchors, the elongate member having a first end fixedly connected to the first anchor.
  • According to yet another aspect of the invention, an assembly for sealing a passageway in a heart is provided. The assembly comprises a guide catheter capable of extending to the passageway, and a closure device capable of sealing the passageway, the closure device including a first anchor adapted to be placed proximate a first end of the passageway, the first anchor including a plurality of first loop structures, each first loop structure having a first end connected to the first anchor and a second free end, a second anchor adapted to be placed proximate a second end of the passageway, and a flexible elongate member adapted to extend through the passageway and connect the first and second anchors, wherein the closure device is positionable within the guide catheter in a first collapsed state and extendable from the guide catheter in a second deployed state.
  • According to another aspect of the invention, a method of sealing a passageway in a human body is provided. The method comprises placing a first anchor proximate a first end of the passageway, the first anchor including a plurality of first loop structures, placing a second anchor proximate a second end of the passageway, and moving the second anchor relative to the first anchor along a flexible elongate member disposed between the first and second anchors within the passageway.
  • According to a further aspect of the invention, a method of placing a closure device to seal a passageway in a human body is provided. The method comprises advancing a catheter into a first end of the passageway and out a second end of the passageway, advancing a first anchor of a closure device out of a distal end of the catheter, withdrawing the catheter through the passageway, positioning the first anchor adjacent the second end of the passageway, advancing a second anchor of the closure device out of the distal end of the catheter, positioning the second anchor of the closure device adjacent the first end of the passageway, and advancing a lock to a position adjacent the second anchor.
  • According to yet another aspect of the invention, a closure device for sealing a passageway in a heart is provided. The closure device comprises a left atrial anchor configured to close a first end of the passageway, a right atrial anchor configured to close a second end of the passageway, at least one of the left atrial anchor and the right atrial anchor including a plurality of loop structures, a flexible elongate member connecting the left and right atrial anchors, wherein the elongate member has a first end fixedly connected to the left atrial anchor and wherein the right atrial anchor is movable with respect to the elongate member, and a lock configured to prevent proximal movement of the right atrial anchor relative to the flexible elongate member.
  • According to another aspect of the invention, a system for sealing a passage in a heart is provided. The system comprises a delivery catheter capable of extending to a position near the passage, a closure device capable of sealing the passage, the device including a first anchor adapted to be placed proximate a first end of the passage, a second anchor adapted to be placed proximate a second end of the passage, and a flexible elongate member adapted to extend through the passage and connect the first and second anchors, and a cutting tool capable of extending over the flexible elongate member to a position near the second anchor.
  • According to yet another aspect of the invention, a device for sealing a passageway in a human body is provided. The device comprises a first anchor adapted to be placed proximate a first end of the passageway, the first anchor including a plurality of first loop structures, each loop structure having a first end connected to the first anchor and a second free end, a second anchor adapted to be placed proximate a second end of the passageway, the second anchor including an element configured to engage a snare, and a flexible elongate member connecting the first and second anchors.
  • According to another aspect of the invention, a device for closing a passageway in a heart comprises a left atrial anchor adapted to be placed in a left atrium of the heart and including a plurality of uncovered arms, a right atrial anchor adapted to be placed in a right atrium of the heart and including a plurality of arms, a cover attached to the plurality of arms, and an element configured to engage a snare, and a flexible elongate member adapted to extend through the passageway and connect the left and right atrial anchors, the elongate member having a first end fixedly connected to the left atrial anchor and a second end releasably connected to the right atrial anchor.
  • According to yet another aspect of the invention, a device for closing a passageway in a heart comprises a left atrial anchor adapted to be placed in a left atrium of the heart and including a plurality of uncovered arms, a right atrial anchor adapted to be placed in a right atrium of the heart and including a plurality of arms and a cover attached to the plurality of arms, a flexible elongate member adapted to extend through the passageway and connect the left and right atrial anchors, the elongate member having a first end fixedly connected to the left atrial anchor, and a lock for preventing proximal movement of the right atrial anchor relative to the flexible elongate member.
  • According to another aspect of the invention, a device for closing a passageway in a heart comprises a left atrial anchor adapted to be placed in a left atrium of the heart and including a plurality of uncovered arms and at least one member connecting each arm to the left atrial anchor, a right atrial anchor adapted to be placed in a right atrium of the heart and including a plurality of arms and a cover attached to the plurality of arms, and a flexible elongate member adapted to extend through the passageway and connect the left and right atrial anchors, the elongate member having a first end fixedly connected to the left atrial anchor and a second end releasably connected to the right atrial anchor.
  • According to a further aspect of the invention, a method for retrieving a device for sealing a passageway in a heart is provided. The method comprises advancing a snare catheter through a guide catheter toward the passageway covered by a second anchor of the device, engaging a portion of the second anchor with the snare, and drawing the second anchor into the guide catheter with the snare.
  • According to yet another aspect of the invention, a cutting tool for severing a flexible elongate member is provided. The cutting tool comprises a cutting tool body having a distal end and a proximal end, the cutting tool body capable of extending through a guide catheter, a guide member for guiding the flexible elongate member, the guide member including a distal opening through which the flexible elongate member enters the cutting tool and a lateral opening through which the flexible elongate member exits the cutting tool, and a cutting surrounding guide wherein the element is movable element surrounding the guide memember, wherein the cutting element is moveable relative to the guide member to cut the flexible elongate member as it exits the guide member through the lateral opening of the guide member.
  • Additional advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The objects and advantages of the invention will be realized and attained by means of the elements and combinations particularly pointed out in the appended claims.
  • The foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate several embodiments of the invention and together with the description, serve to explain the principles of the invention.
  • FIG. 1 is a longitudinal section of a portion of a heart having a PFO;
  • FIG. 2 is a closure device positioned in a heart to close a PFO, according to an embodiment of the present invention;
  • FIG. 3 is a guide catheter inserted through a PFO and into the left atrium, according to an embodiment of the present invention;
  • FIG. 4 is a left atrial anchor of the closure device of FIG. 2 being advanced out of the guide catheter, according to an embodiment of the present invention;
  • FIG. 5 is the left atrial anchor of the closure device of FIG. 4 advanced out of the guide catheter, according to an embodiment of the present invention;
  • FIG. 6 is the left atrial anchor of FIG. 5 being pulled towards the PFO, according to an embodiment of the present invention;
  • FIG. 7 is the guide catheter pulled proximally into the right atrium and the left atrial anchor seated against a septal wall, according to an embodiment of the present invention;
  • FIG. 8 is a right atrial anchor of the closure device of FIG. 2 being extended from the guide catheter, according to an embodiment of the present invention;
  • FIG. 9 is the right atrial anchor deployed from the guide catheter, according to an embodiment of the present invention;
  • FIG. 10 is the right atrial anchor advanced to contact the septal wall, according to an embodiment of the present invention
  • FIG. 11 is the right atrial anchor fixed to a tether of the closure device of FIG. 2, according to an embodiment of the present invention;
  • FIG. 12 is an isometric view of a closure device extending from a delivery catheter, according to one aspect of the invention;
  • FIG. 13 is an isometric view of the closure device of FIG. 12, with a delivery catheter, and a guide catheter, according to an embodiment of the present invention;
  • FIG. 14 is a cross sectional side view of a closure device and a delivery catheter positioned in a loading tube prior to introduction into a guide catheter, according to an embodiment of the present invention;
  • FIG. 15 is a cross-sectional side view of the closure device of FIG. 12 with a lock, according to an embodiment of the present invention;
  • FIG. 16 is an isometric view of the lock used with the closure device in FIG. 14, according to an embodiment of the present invention;
  • FIG. 17 is a side view of an outer tube of the delivery catheter, according to an embodiment of the present invention;
  • FIG. 18 is a side view of an inner tube of the delivery catheter, according to an embodiment of the present invention;
  • FIG. 19 is an isometric view of another embodiment of a closure device, according to the present invention;
  • FIG. 20 is an isometric view of another alternative embodiment of a closure device, according to the present invention;
  • FIG. 21 is a side view of the closure device of FIG. 20; and
  • FIG. 22 is a cross-sectional side view of a portion of a cutting tool, according to one aspect of the present invention.
  • DESCRIPTION OF THE EMBODIMENTS
  • Reference will now be made in detail to embodiments of the invention, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts.
  • The various Figures show embodiments of patent foramen ovale (PFO) closure devices, devices and methods for delivery of the PFO closure devices, and methods of using the device to close a PFO. The devices and related methods are described herein in connection with use in sealing a PFO. These devices, however, also are suitable for closing other openings or passageways, including other such openings in the heart, for example atrial septal defects, ventricular septal defects, and patent ductus arterioses, and openings or passageways in other portions of a body such as an arteriovenous fistula. The invention therefore is not limited to use of the inventive closure devices to close PFOs.
  • FIGS. 2, 12, and 15 show a PFO closure device 10 according to an embodiment of the present invention. In FIG. 2, device 10 is shown positioned on either side of a PFO track (referenced as PFO in the Figures) with a portion of the device 10 passing through the PFO track, after delivery from a delivery system. The PFO track can be seen more clearly in FIG. 3, which shows a catheter disposed in the PFO track between the septum primum (SP) and septum secundum (SS). As shown in FIG. 2, closure device 10 includes a left atrial anchor 12 positioned in the LA, a right atrial anchor 14 positioned in the RA, and a tether 16 connecting the anchor structures.
  • As embodied herein and shown in FIGS. 2, 12, and 15, a PFO closure device 10 includes a left atrial anchor 12, a right atrial anchor 14, a tether 16, and a lock 20. FIG. 12 shows left atrial anchor 12 and right atrial anchor 14 schematically in a deployed condition. As shown in FIGS. 12 and 15, left atrial anchor 12 is permanently secured to the distal end 16 a of the tether 16 via a hub 18. Hub 18 is preferably tubular in shape such that tether 16 extends through hub 18 to right atrial anchor 14. Right atrial anchor 14 is slidably disposed about the tether 16 via a second tubular hub 19. Lock 20 is advanceable along the tether 16, in a distal direction only, to secure the right atrial anchor 14 in position against the atrial tissue defining the PFO track. Tether 16 will be severed adjacent to lock 20; and left atrial anchor 12, right atrial anchor 14 connected to left atrial anchor 12 via tether 16, and lock 20 will remain in the heart to seal the PFO.
  • As shown in FIG. 13, the tether 16 extends through the right atrial anchor 14, through a delivery catheter 32 (that passes through a lumen of a guide catheter 30), and emerges from the proximal end of the delivery catheter 32. An adjustable tether clip 34 provides for temporary securement of the tether 16 relative to the delivery catheter 32. The tether clip 34 may be, for example, a spring-loaded clamp similar to those used to secure laces and drawstrings on backpacks or camping and other equipment.
  • The tether 16 is preferably a high strength flexible polymeric material, such as a braid of polyester yarn. Preferably, such a braided yarn is approximately 0.010 to 0.025 inch in diameter, and most preferably is about 0.0175 inch. Suitable materials include, but are not limited to, multifilament yarns of ultra-high molecular weight polyethylene (UHMWPE) such as SPECTRA™ or DYNEEMA™. Other suitable materials include liquid crystal polymer (LCP) such as VECTRAN™, polyester, or other high strength fibers. Alternatively, the tether 16 could be formed of a high strength polymeric monofilament. The distal end of the tether 16 may be frayed and encapsulated with an adhesive to form a ball shape, which mechanically engages the hub 18, permanently connecting the distal end of the tether 16 to the left atrial anchor 12. Alternatively, the distal end of the tether 16 could be knotted and trimmed to yield a ball shape for engagement with hub 18 of left atrial anchor 12. FIGS. 12 and 15 illustrate an embodiment of left atrial anchor 12 and its connection to tether 16.
  • As embodied herein and shown in FIGS. 12 and 15, left atrial anchor 12 includes one or more arms 40, which extend radially outward from hub 18. As shown, a left atrial anchor 12 preferably includes four arms 40, although fewer or more arms may be provided. Arms 40 preferably form a unitary arm structure, such that the arms are connected to each other around hub 18. Each arm 40 is preferably ovoid in shape to prevent tissue trauma. The primary structural element of the arm 40 is a loop 42, which extends from near the center of the unitary arm structure and hub 18, towards the periphery of the left atrial anchor 12, and loops back towards the hub 18. The outer portion of the loop 42 defines an atraumatic curve. As shown in FIGS. 12 and 15, each arm 40 includes a first end connected to the hub 18 and/or other arms 40 and a second free end formed by the outer portion of the loop 42. At least the portion of each arm 40 that is unconnected to the other arms 40 of the unitary arm structure is freely movable, i.e., it is movable independently from the other arms 40.
  • The unitary arm structure, including the arms 40, is preferably formed from a rolled sheet of binary nickel titanium alloy (also known as nitinol). The alloy is known in the art to have superior elastic properties. The geometry of the unitary arm structure may be formed either by laser cutting or chemical etching. A smooth and passive surface is created by electropolishing. Thermal processing is used to impart a parent shape, as is known in the art. A preferred parent shape is shown in FIG. 15. This curved shape (shown in side view) for the left atrial anchor 12 presents a concave surface to the left atrial wall.
  • The arms 40, as shown in FIG. 12, may incorporate an optional web 44. The web 44 includes one or more radial struts 46, intersected by cross struts 47. The web 44 is preferably thinner in dimension than the loop 42. As such, the web 44 adds relatively little to the stiffness of the arm, but adds redundancy to the arm in the event of a fracture in the loop 42. Since the web 44 is thinner, any oscillating motion (primarily perpendicular to the surface of the arm) imparted to the arms 40 due to the beating of the heart will cause an oscillatory strain on the loop 42. Such a strain will be greatest near the hub 18. However, the strain imparted to the web 44 will be significantly less than that imparted to the loop 42, due to the thinness of the web 44. Thus, in the event of a fracture in the loop 42, the web 44 will maintain a connection between the arm 40 and the remainder of the unitary arm structure forming the left atrial anchor 12.
  • The diameter (span) of the left atrial anchor 12 is primarily determined by the size of the unitary arm structure. In a PFO closure application, the span of the unitary arm structure is preferably from about 10 mm to about 40 mm, and is most preferably from about 15 mm to about 25 mm. The preferred span width of the entire loop 42 at its widest point is preferably from about 0.050 inch to about 0.150 inch, and is most preferably about 0.100 inch. The rolled sheet that forms the loop 42 is preferably between about 0.003 inch and about 0.006 inch uniform thickness, and is most preferably about 0.045 inch, with a width of the loop 42 between about 0.002 inch and about 0.015 inch. The loop 42 is preferably wider near the hub 18, and narrower further away. The struts 46, 47 of the web 44 are thinner than the material forming the loop 42, preferably between about 0.001 inch and about 0.004 inch in width and thickness. The only structure within the left atrium is the relatively small struts of the arms 40, which are preferably well apposed to the wall tissue by virtue of their imparted parent shape. These small struts will readily be incorporated into the tissue of the left atrium, resulting in an endothelialized non-thrombogenic surface.
  • At the center of the unitary arm structure forming the left atrial anchor 12 is a hole, through which the hub 18 is secured. The hub 18 is preferably a tube formed of radiopaque material such as platinum alloy, and is swaged in place, forming a mechanical interlock with the unitary arm structure that forms left atrial anchor 12. The hub 18 serves to engage the distal bulb 16 a of the tether 16, as previously described.
  • To facilitate visualization during and following implantation of the PFO closure device 10, markers 48 are provided on the arms 40. Holes near the free ends of the arms 40 are formed into the geometry of the unitary arm structure. Markers 48 may include, for example, rivets formed from a radiopaque material such as platinum alloy. The markers 48 are positioned into the holes and swaged in place.
  • FIGS. 12 and 15 also illustrate an embodiment of right atrial anchor 14. As embodied herein and shown in FIGS. 12 and 15, right atrial anchor 14 includes arms 50, which extend radially outward from hub 19. The structure of each arm 50 is essentially identical to that described for left atrial anchor 12. As shown in FIGS. 12 and 15, each arm 50 includes a first end connected to the hub 19 and/or other arms 50 and a second free end formed by the outer portion of the loop 52. At least the portion of each arm 50 that is unconnected to the other arms 50 of the unitary arm structure is freely movable, i.e., it is movable independently from the other arms 50. Each arm 50 is formed by a loop 52 and may include a web 54 having at least one radial strut 56 and several cross struts 57. The free end of each arm 50 may include a hole containing a marker 58.
  • With regard to the shape of each arm 50, thermal processing is used to impart a parent shape, as is known in the art. A preferred parent shape is shown in FIG. 15. This curved shape (shown in side view) for the right atrial anchor 14 presents a concave shape to the right atrial wall. This parent shape helps insure that the entire right atrial anchor will be apposed to atrial tissue once implanted. This apposition serves to minimize the chance for excessive thrombus formation and subsequent embolism, and also facilitates rapid incorporation of the anchor by adjacent atrial tissue.
  • The arms 50 form a unitary arm structure that is centered about a hub 19. Hub 19 is tubular, and is preferably formed of a radiopaque material such as platinum alloy. The inner diameter of the hub 19 is slightly larger than the diameter of the tether 16, to allow for the right atrial anchor 14 to slide relative to the tether 16. The hub 19 is secured to the unitary arm structure that forms the right atrial anchor 14 by swaging. A shoulder at the distal end of hub 19 is inserted inside the right atrial anchor 14, and flared by swaging, thus interlocking the hub 19 to the unitary arm structure, as shown in FIG. 15. The hub 19 is preferably about 0.090 inch to about 0.110 inch in length, with an enlarged ring 19 a at the proximal end. This ring 19 a facilitates removal or repositioning of the right atrial anchor 14 by a snare, as will be described later.
  • As embodied herein and shown in FIGS. 12 and 15, the right atrial anchor 14 may include a covering 60. Covering 60 provides assurance of complete closure of the PFO track, and facilitates tissue ingrowth into the right atrial anchor 14. The covering 60 preferably includes two layers, 60 a, 60 b, one on each side of the unitary arm structure that forms right atrial anchor 14. Alteratively, covering 60 may be a single layer attached on one side of the unitary arm structure. Preferably, the covering 60 is formed of a knitted or woven fabric of polyester, but may be formed from any suitable polymeric material such as expanded polytetrafluoroethylene. The covering 60 is secured to the unitary arm structure by suitable means, such as ultrasonically securing the two layers of fabric 60 a, 60 b, at their peripheries, and/or at locations between the arms 50 or within the loops 52. The covering 60 may be generally circular, as shown in FIG. 12, or any other suitable shape. The ends of arms 50 may also include small loops to receive sutures, for example, for suturing to the covering 60 of the unitary arm structure.
  • Positioned proximally to right atrial anchor 14 on tether 16 is a lock 20. As embodied herein and shown in FIG. 16, the lock 20 is disposed about the tether 16. The lock 20 is tubular in shape and may be fabricated from a metallic material, such as a tube of nickel-titanium alloy. The inner diameter of the lock 20 is somewhat larger that the diameter of the tether 16, preferably about 0.010 inch to about 0.015 inch larger, and most preferably about 0.0125 inch larger. The lock 20 may have a wall thickness of between about 0.002 inch and about 0.005 inch, and most preferably about 0.003 inch. Lock 20 includes one or more tabs 22 formed in the tube. Preferably, lock 20 includes six tabs 22, three towards the distal end of the lock 20, and three towards the proximal end of the lock 20. The tabs towards the. distal end are preferably circumferentially offset from the tabs towards the proximal end, better ensuring engagement of lock 20 with the tether 16. The tabs 22 may be formed by laser cutting. Each tab 22 includes a base 24, which connects to the main body of the lock 20, and a point 26, which serves to mechanically engage the tether 16. The tabs 22 are thermally shape set (as is known in the art) to have a parent shape with the tabs 22 deflected inward, such that the points 26 are forced to engage the tether 16. The points 26 engage the tether 16, by extending into the tether 16, when the lock 20 is moved relative to the tether 16 in one direction only. This allows the lock 20 to be advanced distally along the tether 16, while preventing proximal movement of the lock 20 along tether 16.
  • FIG. 19 shows an alternative embodiment of a closure device 110. In at least some respects, the closure device 110 is similar to device 10 described with respect to FIGS. 12 and 15. Similar elements will be labeled with similar reference numerals in the Figure, and the differences between the embodiments will be explained. As embodied herein and shown in FIG. 19, the arms of closure device 110 may not include a web structure. Closure device 110 includes a left atrial anchor 112, a right atrial anchor 114, and a tether 116. Each anchor 112, 114, includes arms 140, 150, respectively. As shown in FIG. 19, each arm 140, 150, may be formed by a loop 142, 152, as previously described with respect to device 10. Arms 140, 150 may also include markers 148, 158, respectively, as previously described.
  • Additionally, the cover 160 for the right atrial anchor 114, as shown in FIG. 19, may be lobular in shape, instead of circular. Cover 160 also preferably includes two layers to effectively sandwich the arms 150. The two layers are preferably secured together at their peripheries 161 as shown, as well as at discrete locations 162 within the loops 152. The layers 160 a, 160 b, are secured by suitable means, such as by ultrasonic welding. The cover 160 could also be incorporated in any of the other embodiments of closure devices described in this application.
  • FIGS. 20 and 21 show another alternative embodiment of a left atrial anchor 212 for a closure device 210. In at least some respects, left atrial anchor 212 is similar to left atrial anchor 112 described with respect to FIG. 19. Similar elements will be labeled with similar reference numerals in the Figures, and the differences between the embodiments will be explained. As embodied herein and shown in FIGS. 20 and 21, left atrial anchor 212 includes four arms 240. As previously discussed with respect to FIG. 19, arms 240 do not include a web structure, and are formed by loops 242. Each arm 240 may include a marker (not shown). Each left atrial arm 240 may further include a structure to prevent embolism of that arm 240, in the event of arm fracture. This structure performs a function similar to that the web 44, shown in FIG. 12, performs.
  • As shown in FIGS. 20 and 21, one or more safety lines 264 extend parallel to the arms 240 of the left atrial anchor 212. Two safety lines 264 a, 264 b are shown in FIG. 20. A first safety line 264 a secures two arms 240 a of the anchor 212, and a second safety line 264 b secures the remaining arms 240 b. Each safety line 264 a, 264 b is preferably formed of a flexible but strong polymeric material, such as a braided filament bundle of polyester or ultra-high molecular weight polyethylene. The safety lines 264 preferably pass through the ends of the arms 240 through holes 266. Although not shown, additional holes may be provided near the ends of the arms to contain markers, as described above. The preferred path for each safety line 264 is shown in FIG. 21. The two ends 265 a, 265 b of the safety line 264 lie next to the distal end of the tether 216. The safety line 264 extends through the hub 218, then along and parallel to two arms 240, through the holes 266, back along and parallel to the two arms 240, and then through the body of the tether 216 itself at a very distal end.
  • Alternatively, each arm 240 may include a separate safety line 264. For example, the end 265 of the line 264 could be adjacent the end of the tether 216 as described above, extend through the hub 218 and parallel to the arm 240 to the hole 266, and terminate in a knot or encapsulated fray at a hole (not shown) in the end of the tether 216, as previously described in connection with the distal end of the tether 216.
  • FIG. 13 shows the closure device 10 positioned relative to an embodiment of a delivery catheter 32. As embodied herein and shown in FIGS. 12, 13, 17, and 18, the delivery catheter 32 includes an outer tube 36 and an inner tube 38. The outer tube 36 may be formed from a polymer, preferably high density polyethylene. The distal portion 36 b of the outer tube 36 preferably has an inner diameter of between about 0.040 inch and about 0.060 inch, and is most preferably about 0.048 inch, with a wall thickness of between about 0.005 and about 0.010 inch, and most preferably about 0.008 inch. As shown in FIG. 17, the distal portion 36 b of the outer tube 36 may taper along its length to the most distal end. Alternatively, the distal portion 36 b of the outer tube may have a constant inner and outer diameter. The proximal portion of the outer tube 36 preferably has an inner diameter of between about 0.050 inch and about 0.070 inch, and is most preferably about 0.060 inch, with a wall thickness of between about 0.005 inch and about 0.010 inch, and most preferably about 0.007 inch. The dimensions of the outer tube 36 are such that it can engage and abut with the hub 19 of the right atrial anchor 14 during the delivery of the device 10. The proximal end of the outer tube 36 includes a rigid sleeve 36 a, formed of a hypotube which surrounds the polymeric tube. The rigid sleeve 36 a serves to prevent kinking of the outer tube 36 during the delivery of the device. The length of the proximal rigid sleeve 36 a is preferably between about 10 cm and about 20 cm, and is most preferably about 14 cm. The length of the outer tube 36, including the rigid sleeve 36 a, is preferably between about 100 cm and about 130 cm, and is most preferably about 115 cm.
  • The inner tube 38 of delivery catheter 32 may be formed from a suitable polymer, such as PEBAX 6333™, and have a preferred inner diameter of between about 0.020 inch and about 0.040 inch, most preferably about 0.030 inch, with a wall thickness of between about 0.003 inch and about 0.010 inch, and most preferably about 0.006 inch. The preferred dimensions of the inner tube 38 are such that it can engage and advance the lock 20 along the tether 16. The distal end 38 b of the inner tube 38 preferably has a uniform inner and outer diameter. The proximal end of the inner tube 38 also includes a rigid sleeve 38 a, formed of a hypotube surrounding the polymeric tube. The length of the rigid sleeve 38 a is preferably between about 15 cm and about 30 cm, and is most preferably about 23 cm. The length of the inner tube 38, including the rigid sleeve 38 a, is preferably between about 90 cm and about 110 cm, and is most preferably about 100 cm.
  • In FIGS. 12 and 13, left atrial anchor 12 and right atrial anchor 14 are shown deployed from delivery catheter 32. As shown in FIG. 13, delivery catheter 32 may be used with a guide catheter 30. Although not shown, guide catheter 30 may have a pre-formed curve near its distal end. Guide catheter 30 can be any suitable, conventional guide catheter. A suitable, exemplary guide catheter is known as “Mullins” guide catheter, sold commercially by Cook. Connected to the proximal end of guide catheter 30 is a hemostasis valve 31.
  • Prior to deployment of closure device 10, guide catheter 30 would be delivered by conventional techniques to the site of the PFO. Such conventional techniques may include the temporary use of a guide wire (not shown).
  • FIG. 14 illustrates the closure device 10 in a collapsed condition prior to delivery, within a loading tube 70. As shown in FIG. 14, loading tube 70 preferably has a flared proximal end to facilitate introduction of the device 10 and delivery catheter 32 into the loading tube 70. This is the state of the closure device 10 and delivery catheter 32 prior to introduction into the previously placed guide catheter 30. As shown in FIG. 14, the outer tube 36 of the delivery catheter 32 has a size that will abut the hub 19 of right atrial anchor 14 as tube 36 moves along tether 16. The right atrial anchor 14 also may move along tether 16 to abut the left atrial anchor 12. This abutment allows the left and right atrial anchors 12, 14 to move in response to movement of the delivery catheter 32 within the guide catheter 30. The condition in which the structures abut one another may be created and maintained by having the tether clip 34 positioned against the proximal end of the delivery catheter 32, after removing any initial slack in the tether 16. As shown in FIG. 14, the arms 40 of the left atrial anchor 12 are collapsed in the distal direction, while the arms 50 of the right atrial anchor 14 are collapsed in a proximal direction.
  • FIGS. 3-11 show sequential steps for delivery of closure device 10, according to one aspect of the invention. At the level of the longitudinal section shown in FIG. 3, the inferior vena cava (IVC) is not shown. In an embodiment, a delivery system is passed through the IVC to gain access to the RA and PFO. Other methods of percutaneously, minimally invasively, or more directly obtaining access to the RA and PFO are within the scope of the invention. As embodied herein and shown in FIG. 3, a guide catheter 30 is advanced to and through the PFO track and into the LA. The guide catheter 30 extends across the PFO track, as shown in FIG. 3. The proximal end of the guide catheter 30 includes a hemostasis valve 31. The loading tube 70, the collapsed closure device 10, and delivery catheter 32 are introduced into the guide catheter 30 through the hemostasis valve 31. When fully inserted into the hemostasis valve 31, the distal end of the loading tube 70 abuts the hub (not shown) of the guide catheter 30, preventing the loading tube 70 from continuing to advance down the lumen of the guide catheter 30. The collapsed closure device 10 is then advanced out the loading tube 70 by advancement of the delivery catheter 32 into the lumen of the guide catheter 30. Advancement of the delivery catheter 32 and collapsed closure device 10 continues until the closure device 10 is near the distal end of the guide catheter 30. The loading tube 70 is then withdrawn out of the hemostasis valve 31 and positioned on the delivery catheter 32 towards the proximal end. The hemostasis valve 31 is then closed to stop back bleeding.
  • The delivery catheter 32 is further advanced relative to the guide catheter 30, deploying only the left atrial anchor 12, as shown in FIGS. 4 and 5. FIG. 5 shows the left atrial anchor 12 fully deployed from the guide catheter 30 in the left atrium. Tether 16 extends from anchor 12 into guide catheter 30 and through delivery catheter 32. As discussed above, left atrial anchor 12 and right atrial anchor 14 are preferably self-expanding structures, expanding through a mechanical or thermal shape change, for example. Also at this point, right atrial anchor 14 remains within the delivery assembly in a collapsed state.
  • The delivery catheter 32 and guide catheter 30 are withdrawn, pulling the left atrial anchor 12 against the opening of the PFO track, as shown in FIG. 6. As the tether clip 34 remains in the initial position abutting the proximal end of the delivery catheter 32, the left atrial anchor 12 is pulled against the opening of the PFO track. Next, the tether clip 34 is re-positioned several centimeters proximally on the tether 16.
  • As shown in FIG. 7, a significant portion of the PFO track (specifically the portion of the track between the superior portion of the septum primum and septum secundum) runs along and roughly parallel with the septal wall. A feature of closure device 10 according to this embodiment is that left atrial anchor 12 and tether 16 are flexibly connected, and tether 16 is itself preferably flexible, to allow tether 16 to extend through the PFO track, while left atrial anchor 12 remains significantly apposed to the left atrial surface. Tether 16 is able to extend from left atrial anchor 12 at an obtuse angle. In many instances, left atrial anchor 12, with tension applied from tether 16, may mechanically close and thereby seal the PFO by bringing the septum primum (SP) into sealing contact with the septum secundum (SS). The effectiveness of this seal can be tested at this time by conventional techniques, such as contrast visualization, or a Valsalva maneuver combined with injection of bubbles, visualized with transesophageal ultrasound or intracardiac ultrasound. If the seal is ineffective, closure device 10 can be removed as described later, and exchanged for a different device. Alternatively, the device 10 can be repositioned as will be described below.
  • The guide catheter 30 and delivery catheter 32 are further withdrawn relative to the PFO track, until the distal end of the guide catheter 30 is well within the right atrium, as shown in FIG. 7. The right atrial anchor 14, still collapsed within the lumen of the guide catheter 30, moves together with the guide catheter 30 and delivery catheter 32. With the tether clip 34 previously positioned proximally, the catheters 30, 32 and the collapsed right atrial anchor 14 can freely slide proximally relative to the tether 16 and the left atrial anchor 12.
  • Once left atrial anchor 12 is positioned, right atrial anchor 14 may be deployed. As shown in FIG. 7, initial deployment of right atrial anchor 14 is preferably performed with the delivery catheter and the collapsed right atrial anchor 14 withdrawn sufficiently away from left atrial anchor 12 and the right atrial septal wall, so that right atrial anchor 14 does not impinge on the wall when it initially expands. This also assures that right atrial anchor 14 will not inadvertently deploy in the PFO track or the left atrium. Because right atrial anchor 14 is not permanently attached to tether 16, anchor 14 is free to be positioned in such a location away from the right atrial septal wall.
  • With the guide catheter 30 positioned in the right atrium, the right atrial anchor 14 is deployed by advancing the delivery catheter 32 relative to the guide catheter 30, as shown in FIGS. 8-10. This relative movement results in full deployment of right atrial anchor 14 within the right atrium RA, as shown in FIG. 9 At this stage of the delivery method, tether 16 passes through right atrial anchor 14 and preferably extends continuously through delivery catheter 32 and guide catheter 30 to the proximal end of the delivery catheter 32. Light tension is maintained on the tether 16 from the proximal end to prevent slack on the portion of the tether 16 between the left and right atrial anchors 12, 14.
  • In the next step of this embodiment of a closure device delivery method, right atrial anchor 14 is advanced into contact with the right atrial septal wall, as shown in FIG. 10. This is accomplished by advancing right atrial anchor 14 and delivery catheter 32 along tether 16 until right atrial anchor 14 is in a desired position relative to left atrial anchor 12, the septal wall, and the PFO, and has a desired amount of tension on left atrial anchor 12. It is preferred that left atrial
  • anchor 12 have sufficient tension applied that the septum primum (SP) is brought into sealing apposition with the septum secundum (SS). This apposition, in many cases, may be enough to effectively close and seal the PFO. If desired, at this point in the delivery method, the effectiveness of the closure and seal can again be tested by conventional techniques, such as those described above. If the seal is ineffective, closure device 10 can be removed as described later, and exchanged for a different device (e.g., one of a different size). Alteratively, the device 10 can be repositioned as described later.
  • The right atrial anchor 14 is advanced until it makes contact with the right atrial end of the PFO track, thus closing it off. The tether clip 34 is then repositioned back to abut the proximal end of the delivery catheter 32 to temporarily maintain the relative positions of the left and right atrial anchors 12, 14. A test of the effectiveness of the closure of the PFO track can then be performed, as described earlier. Note that the distal end of the delivery catheter 32 is not fully connected to the right atrial anchor 14, but is merely abutting it. This arrangement allows for the delivery catheter 32 to pivot relative to the right atrial anchor 14 when abutting the right atrial anchor 14, as shown in FIG. 10. Therefore, the natural orientation that the right atrial anchor 14 takes as it conforms to the wall of the right atrium is not impacted by the orientation of the delivery catheter 32 (or guide catheter 30), enabling the position of the PFO closure device 10 to accurately represent the final state of closure, once the tether is cut and all catheters removed.
  • Up to this point, the two primary components of the delivery catheter 32, the inner tube 38 and the outer tube 36, have been secured together by way of a touhy-borst fitting 33 in a y-adaptor 35 at the proximal end of the outer tube 36, as shown in FIG. 13. The touhy-borst fitting 33 is initially tightened to prevent relative movement between the inner tube 38 and the outer tube 36. The inner tube 38 initially extends several cm proximally of the touhy-borst fitting 33.
  • The lock 20, which is initially positioned on the tether 16, several cm proximal of the distal end of the tether 16, is now advanced distally to permanently secure the position of the right atrial anchor 14 relative to the tether 16. To advance the lock 20, the touhy-borst fitting 33 securing the inner tube 38 and the outer tube 36 is loosened. Then, the inner tube 38 is advanced while maintaining the position of the outer tube 36 against the right atrial anchor 14. To prevent creating slack on the tether 16, light tension is applied at its proximal end.
  • The lock 20 is advanced along the tether 16 under fluoroscopic visualization until it abuts the hub 19 of the right atrial anchor 14. At this point, the delivery catheter 32 is withdrawn several cm, and the PFO closure is re-assessed as discussed previously. In some instances, the right and left atrial anchors 12, 14 may need to be further tightened relative to each other. This can be done by re-advancing the inner tube 38 to the lock 20. The lock 20 is then incrementally advanced along the tether 16, shortening the length of the tether 16 between the left and right atrial anchors 12, 14.
  • At this point, the effectiveness of the closure and sealing of the PFO can be tested by conventional techniques, such as contrast visualization, or a Valsalva maneuver combined with injection of bubbles, visualized with (TEE) or intracardiac ultrasound.
  • Once a satisfactory closure of the PFO track is confirmed, the tether 16 may be cut at a position near the right atrial anchor 14. A cutting tool 80 is used to perform this step. An embodiment of a cutting tool 80 is illustrated in FIG. 22. The cutting tool 80 includes a tubular cutting element 90, preferably formed of stainless steel, with a sharpened distal edge 92. The cutting element 90 is connected to an outer tube 96 via a linking portion 94. Outer tube 96 extends to the proximal end of the cutting tool 80. The outer tube 96 is preferably incorporates a wire braid (not shown) to impart a relatively high torsional stiffness.
  • The cutting element 90 surrounds a tether guide 86, preferably formed from metallic hypotubing, with an outer diameter close to the inner diameter of the cutting element 90. The tether guide 86 incorporates a distal opening 82. A lateral opening 84 is a short distance, preferably about 1 mm to about 5 mm proximal of the distal opening 82. The tether guide 86 is secured about the distal end of a central wire 98. The central wire 98, preferably made of stainless steel, extends proximally through the outer tube 96 to the proximal end of the cutting tool 80. The distal portion of the central wire 98 is enlarged to fill the inside diameter of the tether guide 86. The distal end of the central wire 98 further incorporates a bevel 88. Central wire 98 moves axially and rotationally relative to outer tube 96. At the proximal end of the cutting tool (not shown) is a handle mechanism, which facilitates controlled relative rotation and longitudinal movement between the central wire 98 and the outer tube 96.
  • The initial position of the cutting element 90 is just proximal to the lateral opening 84 in the tether guide 86, as shown in FIG. 22. The handle mechanism when activated causes the outer tube 96 and cutting element 90 to rotate relative to the central wire 98 and the tether guide 86. A screw or other suitable mechanism in the handle mechanism further causes the outer tube 96 and cutting element 90 to advance distally along the tether guide 86, until the cutting element 90 is just distal of the lateral opening 84 thereby severing tether 16.
  • In use, the cutting tool 80 is loaded over the proximal end of the tether 16, as shown in FIG. 22, the tether 16 being inserted in the distal opening 82 of the tether guide 86. The bevel 88 causes the tether 16 to emerge out the lateral opening 84. The cutting tool 80 is advanced along the tether 16 until the distal end of the cutting tool 80 abuts the lock 20. At this point, the handle mechanism is activated, which causes the cutting element 90 to advance and slice the tether 16. The PFO closure device 10 is now fully implanted.
  • There are several points during the delivery of closure device 10 where device 10 can be completely removed from the patient. This may be necessary if, for example, device 10 is not creating a complete seal due to any of a number of causes, including, for example, the selected device being too small.
  • For example, after deployment of the left atrial arm 12, but before deployment of the right atrial arm 14 (the position shown in FIG. 7), the deployed left atrial arm 12 can be captured by advancement of the guide catheter 30 relative to the tether 16 and left atrial anchor 12, which are fixed relative to the PFO track. The guide catheter 30 is advanced through the PFO track until it meets the left atrial anchor 12. The guide catheter 30 continues to advance, causing the left atrial anchor 12 to essentially resume the position it was in prior to initial deployment. Light tension is applied to the tether 16 during the advancement.
  • Alternatively, the device 10 may be retrieved after deployment of the right atrial anchor 14, but before advancement of the lock 20 (the position shown in FIG. 10). The deployed right atrial anchor 14 can be captured by use of a snare catheter (not shown). A preferred snare catheter is commercially available by Microvena (ev3), and sold under the trade name Amplatz Gooseneck Snare. The outer tube 36 of delivery catheter 32 is left in place abutting the right atrial anchor 14. The tether clip 34, y-adaptor, and the inner tube 38 of delivery catheter 32 are all removed from the tether in a proximal direction, leaving the outer tube 36 of delivery catheter 32 in place. The snare is advanced over the proximal end of the outer tube 36 of delivery catheter 32 and along the annular space between the guide catheter 30 and the outer tube 36 of delivery catheter 32. The snare is activated to engage the enlarged ring 19 a on the hub 19 of the right atrial anchor 14. Then the snare, together with the outer tube 36 of delivery catheter 32, is withdrawn relative to the guide catheter 30 and tether 16. Continued proximal movement of the snare causes the right atrial anchor 14 to collapse into the guide catheter 30. Once the collapsed right atrial anchor is near the hemostasis valve 31 of the guide catheter 30, the loading tube 70 is re-advanced through the hemostasis valve 31. The collapsed right atrial anchor 14 is drawn into the loading tube 70, allowing the right atrial anchor 14, outer tube 36 of delivery catheter 32, and snare to be removed from the guide catheter 30. The left atrial anchor 12 then may be removed by advancing the guide catheter 30 through the PFO track, while maintaining tension on the tether 16. Once the guide catheter 30 contacts the left atrial anchor 12, continued advancement of the guide catheter 30 relative to the left atrial anchor 12 will cause it to collapse into the guide catheter 30, allowing subsequent removal.
  • The various described embodiments of closure devices and methods and tools for their delivery are suitable for closure of a wide variety of PFOs. For example, PFOs with a relatively long overlap between the septum primum (SP) and septum secundum (SS) may be suitably closed, as shown in FIG. 2.
  • Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. The specification and examples are exemplary, with a true scope and spirit of the invention being indicated by the following claims.

Claims (33)

  1. 1-58. (canceled)
  2. 59. A method of sealing a passageway in a human body, comprising:
    deploying a flexible elongate member disposed between a first anchor with a plurality of first loop structures and a second anchor;
    supporting each of the plurality of loop structures at a radially proximal end only with the flexible elongate member;
    placing the first anchor proximate a first end of the passageway;
    placing the second anchor proximate a second end of the passageway; and
    moving the second anchor relative to the first anchor along the flexible elongate member.
  3. 60. The method of claim 59, wherein placing the first anchor includes expanding the first anchor from a collapsed state to a deployed state.
  4. 61. The method of claim 59, wherein placing the second anchor includes expanding the second anchor from a collapsed state to a deployed state.
  5. 62. The method of claim 59, wherein the passageway is a patent foramen ovale.
  6. 63. The method of claim 59, wherein placing the first anchor includes contacting the septum primum of a heart with the first anchor.
  7. 64. The method of claim 59, wherein placing the second anchor includes contacting the septum secundum of a heart with the second anchor.
  8. 65. The method of claim 59, wherein moving the second anchor includes moving the second anchor towards the first anchor.
  9. 66. The method of claim 59, further comprising engaging the flexible elongate member with a lock to prevent proximal movement of the second anchor.
  10. 67. The method of claim 59, further comprising severing the flexible elongate member adjacent the second anchor.
  11. 68. The method of claim 59, wherein a first end of the flexible elongate member is connected to the first anchor, and wherein placing the first anchor includes pulling proximally on the flexible elongate member to bring the first anchor into contact with tissue defining the passage.
  12. 69. The method of claim 59, wherein the flexible elongate member passes through the second anchor, and wherein placing the second anchor includes pushing the second anchor in a distal direction to move the second anchor with respect to the flexible elongate member until the second anchor covers an end of the passage.
  13. 70. The method of claim 69, further comprising retrieving the second anchor for re-positioning.
  14. 71. The method of claim 70, wherein retrieving the second anchor includes:
    advancing a snare catheter toward the second anchor, engaging a portion of the second anchor with the snare; and
    pulling the second anchor back toward a guide catheter.
  15. 72. A method of placing a closure device to seal a passageway in a human body, comprising:
    advancing a catheter into a first end of the passageway and out a second end of the passageway;
    advancing a first anchor of a closure device out of a distal end of the catheter;
    withdrawing the catheter through the passageway;
    positioning the first anchor adjacent the second end of the passageway;
    advancing a second anchor of the closure device out of the distal end of the catheter;
    positioning the second anchor of the closure device adjacent the first end of the passageway; and
    advancing a lock to a position adjacent the second anchor.
  16. 73. The method of claim 72, further comprising: positioning the closure device within the catheter.
  17. 74. The method of claim 73, wherein positioning the closure device includes advancing the first anchor, the second anchor, and the lock along a tether, wherein the first and second anchors and lock are pre-mounted on the tether.
  18. 75. The method of claim 72, wherein advancing the first anchor includes expanding the first anchor from a delivery configuration to a deployed configuration.
  19. 76. The method of claim 75, wherein advancing the first anchor further includes advancing a flexible elongate member having a first end connected to the first anchor.
  20. 77. The method of claim 76, wherein positioning the first anchor includes pivoting the first anchor with respect to the flexible elongate member.
  21. 78. The method of claim 72, wherein the first anchor is connected to a first end of a flexible elongate member, and wherein positioning the first anchor includes pivoting the first anchor about the flexible elongate member.
  22. 79. The method of claim 72, wherein advancing the second anchor includes expanding the second anchor from a delivery configuration to a deployed configuration.
  23. 80. The method of claim 79, wherein positioning the second anchor includes moving the second anchor along the flexible elongate member toward the first end of the passageway.
  24. 81. The method of claim 80, further comprising sealingly covering the first end of the passageway with the second anchor.
  25. 82. The method of claim 72, wherein advancing the lock includes moving the lock distally along the flexible elongate member toward the second anchor.
  26. 83. The method of claim 82, further comprising severing the flexible elongate member adjacent the lock after advancing the lock to a position adjacent the second anchor.
  27. 84. The method of claim 72, further comprising assessing the positioning of the first anchor prior to advancing the second anchor.
  28. 85. The method of claim 84, further comprising re-advancing the catheter through the passageway to retrieve the first anchor.
  29. 86. The method of claim 72, further comprising assessing the positioning of the second anchor.
  30. 87. The method of claim 86, further comprising advancing a device to retrieve the second anchor.
  31. 88. The method of claim 87, wherein advancing a device includes advancing a snare catheter.
  32. 89. The method of claim 88, further comprising engaging a portion of the second anchor with the snare catheter.
  33. 90-108. (canceled)
US11522157 2003-04-11 2006-09-16 Closure devices, related delivery methods, and related methods of use Abandoned US20070010852A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10411152 US20040267306A1 (en) 2003-04-11 2003-04-11 Closure devices, related delivery methods, and related methods of use
US11522157 US20070010852A1 (en) 2003-04-11 2006-09-16 Closure devices, related delivery methods, and related methods of use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11522157 US20070010852A1 (en) 2003-04-11 2006-09-16 Closure devices, related delivery methods, and related methods of use

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10411152 Division US20040267306A1 (en) 2003-04-11 2003-04-11 Closure devices, related delivery methods, and related methods of use

Publications (1)

Publication Number Publication Date
US20070010852A1 true true US20070010852A1 (en) 2007-01-11

Family

ID=33298329

Family Applications (5)

Application Number Title Priority Date Filing Date
US10411152 Abandoned US20040267306A1 (en) 2003-04-11 2003-04-11 Closure devices, related delivery methods, and related methods of use
US11522158 Active 2026-10-15 US8574264B2 (en) 2003-04-11 2006-09-16 Method for retrieving a closure device
US11522157 Abandoned US20070010852A1 (en) 2003-04-11 2006-09-16 Closure devices, related delivery methods, and related methods of use
US11522193 Abandoned US20070066994A1 (en) 2003-04-11 2006-09-16 Closure devices, related delivery methods, and related methods of use
US12626175 Active 2023-12-09 US8382796B2 (en) 2003-04-11 2009-11-25 Closure devices, related delivery methods and related methods of use

Family Applications Before (2)

Application Number Title Priority Date Filing Date
US10411152 Abandoned US20040267306A1 (en) 2003-04-11 2003-04-11 Closure devices, related delivery methods, and related methods of use
US11522158 Active 2026-10-15 US8574264B2 (en) 2003-04-11 2006-09-16 Method for retrieving a closure device

Family Applications After (2)

Application Number Title Priority Date Filing Date
US11522193 Abandoned US20070066994A1 (en) 2003-04-11 2006-09-16 Closure devices, related delivery methods, and related methods of use
US12626175 Active 2023-12-09 US8382796B2 (en) 2003-04-11 2009-11-25 Closure devices, related delivery methods and related methods of use

Country Status (4)

Country Link
US (5) US20040267306A1 (en)
EP (1) EP1620017B1 (en)
JP (1) JP4827728B2 (en)
WO (1) WO2004091411A3 (en)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060122633A1 (en) * 2002-06-13 2006-06-08 John To Methods and devices for termination
US20060190030A1 (en) * 2002-06-13 2006-08-24 John To Methods and devices for termination
US20070282157A1 (en) * 2004-02-03 2007-12-06 Atria Medical Inc. Device And Method For Controlling In-Vivo Pressure
US20080172035A1 (en) * 2006-10-18 2008-07-17 Starksen Niel F Methods and devices for catheter advancement and delivery of substances therethrough
US20080234702A1 (en) * 2002-06-13 2008-09-25 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20100185172A1 (en) * 2009-01-20 2010-07-22 Mariel Fabro Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods
US20100234878A1 (en) * 2009-03-16 2010-09-16 Cook Incorporated Closure device with string retractable umbrella
US20110218477A1 (en) * 2001-04-20 2011-09-08 V- Wave Ltd., Methods and apparatus for reducing localized circulatory system pressure
US20120172931A1 (en) * 2009-06-21 2012-07-05 Aesthetics Point Ltd. implanted medical device useful for cosmetic surgery
US8382796B2 (en) 2003-04-11 2013-02-26 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and related methods of use
US8696611B2 (en) 2009-05-04 2014-04-15 V-Wave Ltd. Device and method for regulating pressure in a heart chamber
US8777985B2 (en) 2001-06-01 2014-07-15 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
US8795298B2 (en) 2008-10-10 2014-08-05 Guided Delivery Systems Inc. Tether tensioning devices and related methods
US20150039084A1 (en) * 2006-01-23 2015-02-05 Tamir Levi Heart Anchor Device
US9034034B2 (en) 2010-12-22 2015-05-19 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
US9173646B2 (en) 2009-01-20 2015-11-03 Guided Delivery Systems Inc. Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods
US9629715B2 (en) 2011-07-28 2017-04-25 V-Wave Ltd. Devices for reducing left atrial pressure having biodegradable constriction, and methods of making and using same
US9636106B2 (en) 2008-10-10 2017-05-02 Ancora Heart, Inc. Termination devices and related methods
US9713696B2 (en) 2013-05-21 2017-07-25 V-Wave Ltd. Apparatus and methods for delivering devices for reducing left atrial pressure
US10058321B2 (en) 2015-03-05 2018-08-28 Ancora Heart, Inc. Devices and methods of visualizing and determining depth of penetration in cardiac tissue
US10076403B1 (en) 2009-05-04 2018-09-18 V-Wave Ltd. Shunt for redistributing atrial blood volume
US10092402B2 (en) 2016-09-14 2018-10-09 Ancora Heart, Inc. Devices and methods for heart valve repair

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482224B1 (en) 1996-08-22 2002-11-19 The Trustees Of Columbia University In The City Of New York Endovascular flexible stapling device
US8579936B2 (en) 2005-07-05 2013-11-12 ProMed, Inc. Centering of delivery devices with respect to a septal defect
US20060052821A1 (en) 2001-09-06 2006-03-09 Ovalis, Inc. Systems and methods for treating septal defects
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
US6702835B2 (en) 2001-09-07 2004-03-09 Core Medical, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US8430934B2 (en) * 2002-03-01 2013-04-30 Regents Of The University Of Minnesota Vascular occlusion device
US7293562B2 (en) 2003-03-27 2007-11-13 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US7165552B2 (en) 2003-03-27 2007-01-23 Cierra, Inc. Methods and apparatus for treatment of patent foramen ovale
US7367975B2 (en) 2004-06-21 2008-05-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US6939348B2 (en) 2003-03-27 2005-09-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
WO2004087235A3 (en) 2003-03-27 2005-01-06 Cierra Inc Methods and apparatus for treatment of patent foramen ovale
US7972330B2 (en) 2003-03-27 2011-07-05 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7186251B2 (en) 2003-03-27 2007-03-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US8021362B2 (en) 2003-03-27 2011-09-20 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
EP1648340B1 (en) 2003-05-19 2010-03-03 SeptRx, Inc. Tissue distention device and related methods for therapeutic intervention
US20050192627A1 (en) * 2003-10-10 2005-09-01 Whisenant Brian K. Patent foramen ovale closure devices, delivery apparatus and related methods and systems
US7056286B2 (en) 2003-11-12 2006-06-06 Adrian Ravenscroft Medical device anchor and delivery system
US8257394B2 (en) 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US7347863B2 (en) 2004-05-07 2008-03-25 Usgi Medical, Inc. Apparatus and methods for manipulating and securing tissue
US8444657B2 (en) 2004-05-07 2013-05-21 Usgi Medical, Inc. Apparatus and methods for rapid deployment of tissue anchors
US20060079736A1 (en) 2004-10-13 2006-04-13 Sing-Fatt Chin Method and device for percutaneous left ventricular reconstruction
US8372113B2 (en) * 2005-03-24 2013-02-12 W.L. Gore & Associates, Inc. Curved arm intracardiac occluder
US20060271089A1 (en) 2005-04-11 2006-11-30 Cierra, Inc. Methods and apparatus to achieve a closure of a layered tissue defect
US8298291B2 (en) 2005-05-26 2012-10-30 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US9585651B2 (en) 2005-05-26 2017-03-07 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US20070032821A1 (en) * 2005-06-02 2007-02-08 Chao Chin-Chen Patent foramen ovale closure device
EP1898801B1 (en) * 2005-07-07 2011-12-21 Cordis Corporation Patent foramen ovale closure device with steerable delivery system
US7998095B2 (en) * 2005-08-19 2011-08-16 Boston Scientific Scimed, Inc. Occlusion device
US7824397B2 (en) 2005-08-19 2010-11-02 Boston Scientific Scimed, Inc. Occlusion apparatus
EP1933756B1 (en) 2005-08-19 2016-07-20 CHF Technologies Inc. Steerable lesion excluding heart implants for congestive heart failure
US7837619B2 (en) * 2005-08-19 2010-11-23 Boston Scientific Scimed, Inc. Transeptal apparatus, system, and method
US7766906B2 (en) * 2005-08-19 2010-08-03 Boston Scientific Scimed, Inc. Occlusion apparatus
US8062309B2 (en) * 2005-08-19 2011-11-22 Boston Scientific Scimed, Inc. Defect occlusion apparatus, system, and method
CA2621197A1 (en) 2005-09-01 2007-03-08 Cordis Corporation Patent foramen ovale closure method
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
WO2007030433B1 (en) 2005-09-06 2007-08-23 David J Callaghan Jr Removable intracardiac rf device
US9259267B2 (en) 2005-09-06 2016-02-16 W.L. Gore & Associates, Inc. Devices and methods for treating cardiac tissue
US9034006B2 (en) * 2005-12-01 2015-05-19 Atritech, Inc. Method and apparatus for retrieving an embolized implant
WO2007146887A3 (en) * 2006-06-09 2008-04-17 Cordis Corp Single disc intraluminal patent foramen ovale closure device
US8870916B2 (en) 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US8864809B2 (en) * 2006-08-09 2014-10-21 Coherex Medical, Inc. Systems and devices for reducing the size of an internal tissue opening
US9138208B2 (en) 2006-08-09 2015-09-22 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US8529597B2 (en) 2006-08-09 2013-09-10 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
WO2008036384A3 (en) * 2006-09-21 2008-07-24 Synecor Llc Stomach wall closure devices
US9211115B2 (en) 2006-09-28 2015-12-15 Bioventrix, Inc. Location, time, and/or pressure determining devices, systems, and methods for deployment of lesion-excluding heart implants for treatment of cardiac heart failure and other disease states
DE602007006973D1 (en) * 2006-09-29 2010-07-15 Cordis Corp Intraluminal single disk device for open foramen ovale
WO2008055301A1 (en) * 2006-11-07 2008-05-15 Univ Sydney Devices and methods for the treatment of heart failure
US9232997B2 (en) 2006-11-07 2016-01-12 Corvia Medical, Inc. Devices and methods for retrievable intra-atrial implants
US8460372B2 (en) 2006-11-07 2013-06-11 Dc Devices, Inc. Prosthesis for reducing intra-cardiac pressure having an embolic filter
CN107334512A (en) 2011-02-10 2017-11-10 可维亚媒体公司 Apparatus to create and maintain an intra-atrial pressure relief opening
CA2786575A1 (en) 2010-01-29 2011-08-04 Dc Devices, Inc. Devices and systems for treating heart failure
US9757107B2 (en) 2009-09-04 2017-09-12 Corvia Medical, Inc. Methods and devices for intra-atrial shunts having adjustable sizes
US8617205B2 (en) 2007-02-01 2013-12-31 Cook Medical Technologies Llc Closure device
WO2008094706A3 (en) 2007-02-01 2009-02-19 Cook Inc Closure device and method of closing a bodily opening
WO2008094691A3 (en) * 2007-02-01 2009-02-26 Cook Inc Closure device and method for occluding a bodily passageway
WO2008124603A1 (en) 2007-04-05 2008-10-16 Nmt Medical, Inc. Septal closure device with centering mechanism
JP5282185B2 (en) * 2007-08-31 2013-09-04 株式会社バイタル Ventricle affected part prosthesis and ventricular affected part prosthesis treatment set
WO2009046343A1 (en) 2007-10-03 2009-04-09 Bioventrix (A Chf Technologies, Inc.) Treating dysfunctional cardiac tissue
US8821366B2 (en) 2007-10-24 2014-09-02 Circulite, Inc. Transseptal cannula, tip, delivery system, and method
US8343029B2 (en) * 2007-10-24 2013-01-01 Circulite, Inc. Transseptal cannula, tip, delivery system, and method
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
US8460168B2 (en) * 2009-03-27 2013-06-11 Circulite, Inc. Transseptal cannula device, coaxial balloon delivery device, and methods of using the same
US9636094B2 (en) * 2009-06-22 2017-05-02 W. L. Gore & Associates, Inc. Sealing device and delivery system
US9381006B2 (en) 2009-06-22 2016-07-05 W. L. Gore & Associates, Inc. Sealing device and delivery system
DE102009036817A1 (en) 2009-08-10 2011-02-17 Acoredis Gmbh Occlusion device, useful e.g. for closing the heart defects in a patient and other abnormal body openings, comprises mesh of fibers or film body of highly flexible, elastic materials, where the device is introduced through e.g. catheter
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
WO2011094521A3 (en) 2010-01-29 2011-12-29 Dc Devices, Inc. Devices and methods for reducing venous pressure
US9295456B2 (en) * 2010-02-05 2016-03-29 Nanyang Technological University Occlusion device for closing anatomical defects
WO2012051489A3 (en) 2010-10-15 2012-05-31 Cook Medical Technologies Llc Occlusion device for blocking fluid flow through bodily passages
JP2014519904A (en) * 2011-05-23 2014-08-21 ニティループ リミテッド Body cavity insertion device for deployment mechanism
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
EP2760328A4 (en) 2011-09-30 2016-07-06 Bioventrix Inc Remote pericardial hemostasis for ventricular access and reconstruction or other organ therapies
WO2013096965A1 (en) 2011-12-22 2013-06-27 Dc Devices, Inc. Methods and devices for intra-atrial devices having selectable flow rates
US9005155B2 (en) 2012-02-03 2015-04-14 Dc Devices, Inc. Devices and methods for treating heart failure
US9649480B2 (en) 2012-07-06 2017-05-16 Corvia Medical, Inc. Devices and methods of treating or ameliorating diastolic heart failure through pulmonary valve intervention
US20140046347A1 (en) * 2012-08-10 2014-02-13 W. L. Gore & Associates, Inc. Devices, systems and methods for engaging tissue
US9775636B2 (en) 2013-03-12 2017-10-03 Corvia Medical, Inc. Devices, systems, and methods for treating heart failure
US20140364899A1 (en) * 2013-06-11 2014-12-11 ProMed, Inc. Systems and methods for improved vessel access closure
US10010328B2 (en) 2013-07-31 2018-07-03 NeuVT Limited Endovascular occlusion device with hemodynamically enhanced sealing and anchoring
EP3027124A2 (en) 2013-07-31 2016-06-08 Emba Medical Limited Methods and devices for endovascular embolization
WO2015127013A1 (en) * 2014-02-24 2015-08-27 Boston Scientific Scimed, Inc. Hemostasis devices
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
JP2017530756A (en) * 2014-09-19 2017-10-19 エンドチョイス インコーポレイテッドEndochoice, Inc. Method of attaching the mesh to cover the loop member of a surgical snare device
EP3364889A1 (en) * 2015-10-23 2018-08-29 Endochoice, Inc. Method of attaching a mesh to a coated loop member of a surgical snare device

Citations (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3638388A (en) * 1970-01-22 1972-02-01 Anthony J Crookston Method of applying shingles
US3638652A (en) * 1970-06-01 1972-02-01 James L Kelley Surgical instrument for intraluminal anastomosis
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US4007743A (en) * 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4083162A (en) * 1977-04-08 1978-04-11 Regan Joseph F Connector assembly
US4309776A (en) * 1980-05-13 1982-01-12 Ramon Berguer Intravascular implantation device and method of using the same
US4368736A (en) * 1980-11-17 1983-01-18 Kaster Robert L Anastomotic fitting
US4503569A (en) * 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
US4592754A (en) * 1983-09-09 1986-06-03 Gupte Pradeep M Surgical prosthetic vessel graft and catheter combination and method
US4649922A (en) * 1986-01-23 1987-03-17 Wiktor Donimik M Catheter arrangement having a variable diameter tip and spring prosthesis
US4665906A (en) * 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4733665A (en) * 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4748982A (en) * 1987-01-06 1988-06-07 Advanced Cardiovascular Systems, Inc. Reinforced balloon dilatation catheter with slitted exchange sleeve and method
US4826487A (en) * 1987-05-04 1989-05-02 Victory Engineering Company Alignment button for stereotaxic plug and method of using the same
US4832055A (en) * 1988-07-08 1989-05-23 Palestrant Aubrey M Mechanically locking blood clot filter
US4836204A (en) * 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
US4917089A (en) * 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
US4921484A (en) * 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US5078736A (en) * 1990-05-04 1992-01-07 Interventional Thermodynamics, Inc. Method and apparatus for maintaining patency in the body passages
US5098440A (en) * 1990-08-14 1992-03-24 Cordis Corporation Object retrieval method and apparatus
US5104399A (en) * 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US5108420A (en) * 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5176692A (en) * 1991-12-09 1993-01-05 Wilk Peter J Method and surgical instrument for repairing hernia
US5190536A (en) * 1988-11-08 1993-03-02 Health Research, Inc. Submersible lens fiberoptic assembly for use in PDT treatment
US5192301A (en) * 1989-01-17 1993-03-09 Nippon Zeon Co., Ltd. Closing plug of a defect for medical use and a closing plug device utilizing it
US5207695A (en) * 1989-06-19 1993-05-04 Trout Iii Hugh H Aortic graft, implantation device, and method for repairing aortic aneurysm
US5211658A (en) * 1991-11-05 1993-05-18 New England Deaconess Hospital Corporation Method and device for performing endovascular repair of aneurysms
US5211683A (en) * 1991-07-03 1993-05-18 Maginot Thomas J Method of implanting a graft prosthesis in the body of a patient
US5275622A (en) * 1983-12-09 1994-01-04 Harrison Medical Technologies, Inc. Endovascular grafting apparatus, system and method and devices for use therewith
US5284486A (en) * 1991-06-11 1994-02-08 Microvena Corporation Self-centering mechanical medical device
US5284488A (en) * 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
US5304184A (en) * 1992-10-19 1994-04-19 Indiana University Foundation Apparatus and method for positive closure of an internal tissue membrane opening
US5304220A (en) * 1991-07-03 1994-04-19 Maginot Thomas J Method and apparatus for implanting a graft prosthesis in the body of a patient
US5306234A (en) * 1993-03-23 1994-04-26 Johnson W Dudley Method for closing an atrial appendage
US5316023A (en) * 1992-01-08 1994-05-31 Expandable Grafts Partnership Method for bilateral intra-aortic bypass
US5385562A (en) * 1990-10-29 1995-01-31 Scimed Life Systems, Inc. Guide catheter system for an angioplasty balloon catheter
US5387235A (en) * 1991-10-25 1995-02-07 Cook Incorporated Expandable transluminal graft prosthesis for repair of aneurysm
US5391156A (en) * 1992-06-30 1995-02-21 Ethicon, Inc. Flexible encoscopic surgical port
US5397355A (en) * 1994-07-19 1995-03-14 Stentco, Inc. Intraluminal stent
US5417699A (en) * 1992-12-10 1995-05-23 Perclose Incorporated Device and method for the percutaneous suturing of a vascular puncture site
US5486193A (en) * 1992-01-22 1996-01-23 C. R. Bard, Inc. System for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
US5489295A (en) * 1991-04-11 1996-02-06 Endovascular Technologies, Inc. Endovascular graft having bifurcation and apparatus and method for deploying the same
US5490856A (en) * 1993-12-14 1996-02-13 Untied States Surgical Corporation Purse string stapler
US5496365A (en) * 1992-07-02 1996-03-05 Sgro; Jean-Claude Autoexpandable vascular endoprosthesis
US5507769A (en) * 1994-10-18 1996-04-16 Stentco, Inc. Method and apparatus for forming an endoluminal bifurcated graft
US5597378A (en) * 1983-10-14 1997-01-28 Raychem Corporation Medical devices incorporating SIM alloy elements
US5607444A (en) * 1993-12-02 1997-03-04 Advanced Cardiovascular Systems, Inc. Ostial stent for bifurcations
US5614204A (en) * 1995-01-23 1997-03-25 The Regents Of The University Of California Angiographic vascular occlusion agents and a method for hemostatic occlusion
US5617878A (en) * 1996-05-31 1997-04-08 Taheri; Syde A. Stent and method for treatment of aortic occlusive disease
US5618311A (en) * 1994-09-28 1997-04-08 Gryskiewicz; Joseph M. Surgical subcuticular fastener system
US5709707A (en) * 1995-10-30 1998-01-20 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US5709224A (en) * 1995-06-07 1998-01-20 Radiotherapeutics Corporation Method and device for permanent vessel occlusion
US5725552A (en) * 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5725568A (en) * 1995-06-27 1998-03-10 Scimed Life Systems, Inc. Method and device for recanalizing and grafting arteries
US5733294A (en) * 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
US5735290A (en) * 1993-02-22 1998-04-07 Heartport, Inc. Methods and systems for performing thoracoscopic coronary bypass and other procedures
US5741297A (en) * 1996-08-28 1998-04-21 Simon; Morris Daisy occluder and method for septal defect repair
US5749894A (en) * 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
US5865791A (en) * 1995-06-07 1999-02-02 E.P. Technologies Inc. Atrial appendage stasis reduction procedure and devices
US5868762A (en) * 1997-09-25 1999-02-09 Sub-Q, Inc. Percutaneous hemostatic suturing device and method
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5885258A (en) * 1996-02-23 1999-03-23 Memory Medical Systems, Inc. Medical instrument with slotted memory metal tube
US5891558A (en) * 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US5904703A (en) * 1996-05-08 1999-05-18 Bard Connaught Occluder device formed from an open cell foam material
US5904680A (en) * 1992-09-25 1999-05-18 Ep Technologies, Inc. Multiple electrode support structures having optimal bio-mechanical characteristics
US5906207A (en) * 1996-04-04 1999-05-25 Merck & Co., Inc. Method for simulating heart failure
US6013190A (en) * 1998-01-21 2000-01-11 Vascular Science Inc. Catheters with integrated lumen and methods of their manufacture and use
US6021340A (en) * 1995-06-07 2000-02-01 Cardima, Inc. Guiding catheter for the coronary sinus
US6024756A (en) * 1996-03-22 2000-02-15 Scimed Life Systems, Inc. Method of reversibly closing a septal defect
US6026814A (en) * 1997-03-06 2000-02-22 Scimed Life Systems, Inc. System and method for percutaneous coronary artery bypass
US6036716A (en) * 1996-07-09 2000-03-14 Kruchinin; Boris Petrovich Micro-surgery fixation device, variants manipulation push-bar for mounting the same
US6035856A (en) * 1997-03-06 2000-03-14 Scimed Life Systems Percutaneous bypass with branching vessel
US6036702A (en) * 1997-04-23 2000-03-14 Vascular Science Inc. Medical grafting connectors and fasteners
US6168622B1 (en) * 1996-01-24 2001-01-02 Microvena Corporation Method and apparatus for occluding aneurysms
US6171329B1 (en) * 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US6174322B1 (en) * 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US6193734B1 (en) * 1998-01-23 2001-02-27 Heartport, Inc. System for performing vascular anastomoses
US6206907B1 (en) * 1999-05-07 2001-03-27 Cardia, Inc. Occlusion device with stranded wire support arms
US6210338B1 (en) * 1998-08-21 2001-04-03 Aga Medical Corp. Sizing catheter for measuring cardiovascular structures
US6214029B1 (en) * 2000-04-26 2001-04-10 Microvena Corporation Septal defect occluder
US6231561B1 (en) * 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6334864B1 (en) * 2000-05-17 2002-01-01 Aga Medical Corp. Alignment member for delivering a non-symmetric device with a predefined orientation
US20020022860A1 (en) * 2000-08-18 2002-02-21 Borillo Thomas E. Expandable implant devices for filtering blood flow from atrial appendages
US20020026094A1 (en) * 1993-02-22 2002-02-28 Roth Alex T. Devices for less-invasive intracardiac interventions
US6355052B1 (en) * 1996-02-09 2002-03-12 Pfm Produkte Fur Die Medizin Aktiengesellschaft Device for closure of body defect openings
US20020035374A1 (en) * 2000-09-21 2002-03-21 Borillo Thomas E. Apparatus for implanting devices in atrial appendages
US6368338B1 (en) * 1999-03-05 2002-04-09 Board Of Regents, The University Of Texas Occlusion method and apparatus
US6368339B1 (en) * 1994-07-08 2002-04-09 Aga Medical Corporation Method of forming medical devices: intra-vascular occlusion devices
US20020042625A1 (en) * 1997-09-26 2002-04-11 Stack Richard S. Perfusion-occlusion apparatus and methods
US6371971B1 (en) * 1999-11-15 2002-04-16 Scimed Life Systems, Inc. Guidewire filter and methods of use
US6379368B1 (en) * 1999-05-13 2002-04-30 Cardia, Inc. Occlusion device with non-thrombogenic properties
US6391044B1 (en) * 1997-02-03 2002-05-21 Angioguard, Inc. Vascular filter system
US7338514B2 (en) * 2001-06-01 2008-03-04 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use

Family Cites Families (228)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB489316A (en) 1936-05-05 1938-07-25 Davis & Geck Inc Improvements in or relating to devices for use in surgery
US3221746A (en) 1963-01-25 1965-12-07 Noble John William Surgical connecting device
US3402710A (en) 1966-06-27 1968-09-24 Hydra Power Corp Self-closing valve device for implantation in the human body
US3540431A (en) 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US3620212A (en) 1970-06-15 1971-11-16 Robert D Fannon Jr Intrauterine contraceptive device
US3844302A (en) 1970-09-14 1974-10-29 Telesco Brophey Ltd Collapsible umbrella
US4041090A (en) * 1976-03-04 1977-08-09 Shell Oil Company Ethylbenzene process using an unsupported perfluorinated polymer catalyst
US4041931A (en) 1976-05-17 1977-08-16 Elliott Donald P Radiopaque anastomosis marker
US4603693A (en) 1977-05-26 1986-08-05 United States Surgical Corporation Instrument for circular surgical stapling of hollow body organs and disposable cartridge therefor
DE2822603C2 (en) 1978-05-24 1987-03-26 Kay Dr. 7809 Denzlingen De Thierfelder
US4341218A (en) 1978-05-30 1982-07-27 University Of California Detachable balloon catheter
US4214587A (en) 1979-02-12 1980-07-29 Sakura Chester Y Jr Anastomosis device and method
US4485816A (en) 1981-06-25 1984-12-04 Alchemia Shape-memory surgical staple apparatus and method for use in surgical suturing
US5067957A (en) 1983-10-14 1991-11-26 Raychem Corporation Method of inserting medical devices incorporating SIM alloy elements
JPS61500302A (en) 1983-10-20 1986-02-27
US4787899A (en) 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US5669936A (en) 1983-12-09 1997-09-23 Endovascular Technologies, Inc. Endovascular grafting system and method for use therewith
US5693083A (en) 1983-12-09 1997-12-02 Endovascular Technologies, Inc. Thoracic graft and delivery catheter
US4617932A (en) 1984-04-25 1986-10-21 Elliot Kornberg Device and method for performing an intraluminal abdominal aortic aneurysm repair
US5041082A (en) 1986-06-16 1991-08-20 Samuel Shiber Mechanical atherectomy system and method
DK151404C (en) 1984-05-23 1988-07-18 Cook Europ Aps William Collapsible filter for implantation in a patient's blood vessel
US4629451A (en) 1985-09-23 1986-12-16 Victory Engineering Corp. Stereotaxic array plug
US4710192A (en) 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
WO1989006551A1 (en) * 1988-01-12 1989-07-27 Kievsky Nauchno-Issledovatelsky Institut Neirokhir Occluding device
US5067489A (en) 1988-08-16 1991-11-26 Flexmedics Corporation Flexible guide with safety tip
US5052386A (en) 1989-10-12 1991-10-01 Cook, Inc. Method and apparatus for replacing a placed endotracheal tube
US5135467A (en) 1989-12-07 1992-08-04 Medtronic, Inc. Implantable system and method for coronary perfusions assistance
US5122136A (en) 1990-03-13 1992-06-16 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
CA2057018C (en) 1990-04-02 1997-12-09 Kanji Inoue Device for nonoperatively occluding a defect
EP0525110B1 (en) 1990-04-19 1997-06-04 InStent Inc. Device for the treatment of constricted vessels
US5171233A (en) * 1990-04-25 1992-12-15 Microvena Corporation Snare-type probe
US5360443A (en) 1990-06-11 1994-11-01 Barone Hector D Aortic graft for repairing an abdominal aortic aneurysm
FR2663217B1 (en) 1990-06-15 1992-10-16 Antheor Filter device intended for the prevention of embolisms.
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5234447A (en) 1990-08-28 1993-08-10 Robert L. Kaster Side-to-end vascular anastomotic staple apparatus
US5366462A (en) 1990-08-28 1994-11-22 Robert L. Kaster Method of side-to-end vascular anastomotic stapling
US5354309A (en) 1991-10-11 1994-10-11 Angiomed Ag Apparatus for widening a stenosis in a body cavity
US5042707A (en) 1990-10-16 1991-08-27 Taheri Syde A Intravascular stapler, and method of operating same
US5527292A (en) 1990-10-29 1996-06-18 Scimed Life Systems, Inc. Intravascular device for coronary heart treatment
US5122156A (en) 1990-12-14 1992-06-16 United States Surgical Corporation Apparatus for securement and attachment of body organs
US5219895A (en) 1991-01-29 1993-06-15 Autogenesis Technologies, Inc. Collagen-based adhesives and sealants and methods of preparation and use thereof
US5628783A (en) 1991-04-11 1997-05-13 Endovascular Technologies, Inc. Bifurcated multicapsule intraluminal grafting system and method
US5254133A (en) 1991-04-24 1993-10-19 Seid Arnold S Surgical implantation device and related method of use
US5350398A (en) 1991-05-13 1994-09-27 Dusan Pavcnik Self-expanding filter for percutaneous insertion
JP3307392B2 (en) * 1991-05-29 2002-07-24 オリジン・メドシステムズ・インク Organ retraction device for endoscopic surgery
US5147370A (en) 1991-06-12 1992-09-15 Mcnamara Thomas O Nitinol stent for hollow body conduits
US5464408A (en) 1991-06-14 1995-11-07 Duc; Jerome Transluminal implantation or extraction device
JPH07500023A (en) 1991-07-04 1995-01-05
US5370685A (en) 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
CA2078530A1 (en) 1991-09-23 1993-03-24 Jay Erlebacher Percutaneous arterial puncture seal device and insertion tool therefore
EP0539237A1 (en) 1991-10-25 1993-04-28 Cook Incorporated Expandable transluminal graft prosthesis for repair of aneurysm and method for implanting
CA2079417C (en) * 1991-10-28 2003-01-07 Lilip Lau Expandable stents and method of making same
CA2082090C (en) 1991-11-05 2004-04-27 Jack Fagan Improved occluder for repair of cardiac and vascular defects
EP0545091B1 (en) 1991-11-05 1999-07-07 The Children's Medical Center Corporation Occluder for repair of cardiac and vascular defects
US5258000A (en) 1991-11-25 1993-11-02 Cook Incorporated Tissue aperture repair device
US5258042A (en) 1991-12-16 1993-11-02 Henry Ford Health System Intravascular hydrogel implant
JP3393383B2 (en) * 1992-01-21 2003-04-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Septal defect closure device
FR2689388B1 (en) 1992-04-07 1999-07-16 Celsa Lg blood filter perfects possibly resorbable.
GB9207808D0 (en) 1992-04-09 1992-05-27 Lazim Taha R Vascular graft apparatus
DE69322862D1 (en) 1992-04-21 1999-02-11 Baxter Int Vascular implant system
US5540712A (en) 1992-05-01 1996-07-30 Nitinol Medical Technologies, Inc. Stent and method and apparatus for forming and delivering the same
US5366504A (en) 1992-05-20 1994-11-22 Boston Scientific Corporation Tubular medical prosthesis
GB2269321B (en) 1992-08-05 1996-06-26 Nat Heart & Lung Inst Implantable occluder devices for medical use
US5443478A (en) 1992-09-02 1995-08-22 Board Of Regents, The University Of Texas System Multi-element intravascular occlusion device
US5527338A (en) 1992-09-02 1996-06-18 Board Of Regents, The University Of Texas System Intravascular device
WO1994006460A1 (en) 1992-09-21 1994-03-31 Vitaphore Corporation Embolization plugs for blood vessels
US5382259A (en) 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5443454A (en) 1992-12-09 1995-08-22 Terumo Kabushiki Kaisha Catheter for embolectomy
BE1006440A3 (en) 1992-12-21 1994-08-30 Dereume Jean Pierre Georges Em Luminal endoprosthesis AND METHOD OF PREPARATION.
US5433497A (en) * 1993-01-12 1995-07-18 Masco Building Products Corporation Door latch with privacy feature
US5452733A (en) 1993-02-22 1995-09-26 Stanford Surgical Technologies, Inc. Methods for performing thoracoscopic coronary artery bypass
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5478354A (en) 1993-07-14 1995-12-26 United States Surgical Corporation Wound closing apparatus and method
CA2125258C (en) 1993-08-05 1998-12-22 Dinah B Quiachon Multicapsule intraluminal grafting system and method
US5634292A (en) 1993-10-29 1997-06-03 Kitterman; Roger L. Apparatus and method for attracting and trapping insects
US5527322A (en) 1993-11-08 1996-06-18 Perclose, Inc. Device and method for suturing of internal puncture sites
US5443497A (en) 1993-11-22 1995-08-22 The Johns Hopkins University Percutaneous prosthetic by-pass graft and method of use
US5466242A (en) 1994-02-02 1995-11-14 Mori; Katsushi Stent for biliary, urinary or vascular system
US5609627A (en) 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
GB9403088D0 (en) * 1994-02-18 1994-04-06 Burnham Jeffrey Condensation trap
US5840064A (en) 1994-03-31 1998-11-24 United States Surgical Corporation Method and apparatus for treating stenosis or other constriction in a bodily conduit
US5522836A (en) 1994-06-27 1996-06-04 Target Therapeutics, Inc. Electrolytically severable coil assembly with movable detachment point
JPH10504738A (en) 1994-07-08 1998-05-12 マイクロベナ コーポレイション Forming method and vascular embolization device of the medical device
US5846261A (en) 1994-07-08 1998-12-08 Aga Medical Corp. Percutaneous catheter directed occlusion devices
US5433727A (en) 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
US5702421A (en) * 1995-01-11 1997-12-30 Schneidt; Bernhard Closure device for closing a vascular opening, such as patent ductus arteriosus
US5843170A (en) 1994-09-02 1998-12-01 Ahn; Sam Seunghae Apparatus and method for performing aneurysm repair
ES2242132T3 (en) 1994-09-15 2005-11-01 C.R. Bard Inc. Stent and associated placement device.
US5522882A (en) 1994-10-21 1996-06-04 Impra, Inc. Method and apparatus for balloon expandable stent-graft delivery
DE69532966T2 (en) 1994-11-09 2004-10-21 Endotex Interventional Sys Inc Combination of tax-catheter and implant for aneurysm
EP0712614B1 (en) 1994-11-15 2003-04-02 Advanced Cardiovascular Systems, Inc. Intraluminal stent for attaching a graft
US5591226A (en) 1995-01-23 1997-01-07 Schneider (Usa) Inc. Percutaneous stent-graft and method for delivery thereof
US5634936A (en) 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
WO1996025897A3 (en) 1995-02-22 1996-11-21 Menlo Care Inc Covered expanding mesh stent
US5976159A (en) * 1995-02-24 1999-11-02 Heartport, Inc. Surgical clips and methods for tissue approximation
US5695504A (en) 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US6110187A (en) 1995-02-24 2000-08-29 Heartport, Inc. Device and method for minimizing heart displacements during a beating heart surgical procedure
US6124523A (en) 1995-03-10 2000-09-26 Impra, Inc. Encapsulated stent
US5591197A (en) 1995-03-14 1997-01-07 Advanced Cardiovascular Systems, Inc. Expandable stent forming projecting barbs and method for deploying
CA2171896C (en) 1995-03-17 2007-05-15 Scott C. Anderson Multi-anchor stent
US5645558A (en) 1995-04-20 1997-07-08 Medical University Of South Carolina Anatomically shaped vasoocclusive device and method of making the same
US5849005A (en) 1995-06-07 1998-12-15 Heartport, Inc. Method and apparatus for minimizing the risk of air embolism when performing a procedure in a patient's thoracic cavity
US5681336A (en) 1995-09-07 1997-10-28 Boston Scientific Corporation Therapeutic device for treating vien graft lesions
US5702412A (en) 1995-10-03 1997-12-30 Cedars-Sinai Medical Center Method and devices for performing vascular anastomosis
JPH11513577A (en) 1995-10-13 1999-11-24 トランスバスキュラー インコーポレイテッド Apparatus for tissue between transluminal intervention, the system and method
JP2000505316A (en) * 1996-02-02 2000-05-09 トランスバスキュラー インコーポレイテッド Method and apparatus for joining the opening formed in the adjacent vessel or other anatomical structure
DE69633411D1 (en) 1995-10-13 2004-10-21 Transvascular Inc A device for avoidance of arterial constrictions and / or to perform other interventions transvaskularer
DE19542733A1 (en) 1995-11-16 1997-07-24 Mathias Mandlier System for anastomising blood vessels
DE69628722T2 (en) 1995-12-04 2004-04-29 Boston Scientific Ltd., St. Michael Mikrovasookklusive devices with fibers
US5775778A (en) 1996-02-29 1998-07-07 Prescient Partners, Lp Shape adaptable and renewable furniture system
US6042578A (en) 1996-05-13 2000-03-28 Schneider (Usa) Inc. Catheter reinforcing braids
US5830228A (en) 1996-05-29 1998-11-03 Urosurge, Inc. Methods and systems for deployment of a detachable balloon at a target site in vivo
US5676670A (en) 1996-06-14 1997-10-14 Beth Israel Deaconess Medical Center Catheter apparatus and method for creating a vascular bypass in-vivo
US5669933A (en) 1996-07-17 1997-09-23 Nitinol Medical Technologies, Inc. Removable embolus blood clot filter
US5833698A (en) 1996-07-23 1998-11-10 United States Surgical Corporation Anastomosis instrument and method
CN1225565A (en) 1996-07-24 1999-08-11 詹·奥托·索里姆 Anastomotic fitting
US5755778A (en) * 1996-10-16 1998-05-26 Nitinol Medical Technologies, Inc. Anastomosis device
US5843176A (en) * 1996-10-17 1998-12-01 Cordis Corporation Self-expanding endoprosthesis
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
DE69732791D1 (en) 1996-11-07 2005-04-21 St Jude Medical Atg Inc Medical graft connector
WO1998019631A1 (en) 1996-11-07 1998-05-14 Vascular Science Inc. Artificial medical graft methods and apparatus
US5976178A (en) 1996-11-07 1999-11-02 Vascular Science Inc. Medical grafting methods
US6071279A (en) 1996-12-19 2000-06-06 Ep Technologies, Inc. Branched structures for supporting multiple electrode elements
US5776097A (en) 1996-12-19 1998-07-07 University Of California At Los Angeles Method and device for treating intracranial vascular aneurysms
US6206911B1 (en) 1996-12-19 2001-03-27 Simcha Milo Stent combination
US6076012A (en) 1996-12-19 2000-06-13 Ep Technologies, Inc. Structures for supporting porous electrode elements
US5776162A (en) 1997-01-03 1998-07-07 Nitinol Medical Technologies, Inc. Vessel implantable shape memory appliance with superelastic hinged joint
US20020138094A1 (en) 1999-02-12 2002-09-26 Thomas Borillo Vascular filter system
US5782860A (en) 1997-02-11 1998-07-21 Biointerventional Corporation Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method
US6155264A (en) 1997-03-06 2000-12-05 Scimed Life Systems, Inc. Percutaneous bypass by tunneling through vessel wall
US5853419A (en) 1997-03-17 1998-12-29 Surface Genesis, Inc. Stent
WO1998047430A1 (en) * 1997-04-23 1998-10-29 Vascular Science Inc. Medical plug
US6120432A (en) 1997-04-23 2000-09-19 Vascular Science Inc. Medical grafting methods and apparatus
WO1998055027A3 (en) 1997-06-05 2001-06-07 Vascular Science Inc Minimally invasive medical bypass methods and apparatus using partial relocation of tubular body conduit
US5843175A (en) 1997-06-13 1998-12-01 Global Therapeutics, Inc. Enhanced flexibility surgical stent
US6071292A (en) 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
DE29713335U1 (en) 1997-07-26 1997-10-16 Quatchadze Georg Dr Med A surgical instrument for joining two hollow organs
US5922022A (en) 1997-09-04 1999-07-13 Kensey Nash Corporation Bifurcated connector system for coronary bypass grafts and methods of use
US6074416A (en) 1997-10-09 2000-06-13 St. Jude Medical Cardiovascular Group, Inc. Wire connector structures for tubular grafts
DE69833882D1 (en) 1998-01-30 2006-05-11 St Jude Medical Atg Inc Medical graft connector or plug as well as process for their production
US5944738A (en) * 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
US6632236B2 (en) 1999-03-12 2003-10-14 Arteria Medical Science, Inc. Catheter having radially expandable main body
US6540712B1 (en) * 1998-03-13 2003-04-01 Arteria Medical Science, Inc. Methods and low profile apparatus for reducing embolization during treatment of carotid artery disease
JP3799810B2 (en) * 1998-03-30 2006-07-19 ニプロ株式会社 Closure plugs and catheter assembly for transcatheter surgery
US7396359B1 (en) 1998-05-29 2008-07-08 Bypass, Inc. Vascular port device
US5910155A (en) 1998-06-05 1999-06-08 United States Surgical Corporation Vascular wound closure system
US5935148A (en) 1998-06-24 1999-08-10 Target Therapeutics, Inc. Detachable, varying flexibility, aneurysm neck bridge
US6241678B1 (en) 1998-08-21 2001-06-05 Aga Medical Corporation Sizing catheter for measuring septal defects
US6502746B1 (en) * 1998-09-02 2003-01-07 Citicorp Development Center, Inc. Device, method, and system for extracting deposited items from an ATM/CAT safe
US5919200A (en) 1998-10-09 1999-07-06 Hearten Medical, Inc. Balloon catheter for abrading a patent foramen ovale and method of using the balloon catheter
US7044134B2 (en) * 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
US6152144A (en) 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6113612A (en) 1998-11-06 2000-09-05 St. Jude Medical Cardiovascular Group, Inc. Medical anastomosis apparatus
JP3906475B2 (en) 1998-12-22 2007-04-18 ニプロ株式会社 Closure plugs and catheter assembly for transcatheter surgery
DE69931018D1 (en) 1998-12-30 2006-06-01 Ethicon Inc Thread belay device
US20020169474A1 (en) 1999-03-08 2002-11-14 Microvena Corporation Minimally invasive medical device deployment and retrieval system
US6245012B1 (en) * 1999-03-19 2001-06-12 Nmt Medical, Inc. Free standing filter
US6537299B1 (en) * 1999-04-05 2003-03-25 Ethicon, Inc. Intravascular hemostasis device and method
US6656206B2 (en) * 1999-05-13 2003-12-02 Cardia, Inc. Occlusion device with non-thrombogenic properties
US6712836B1 (en) * 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
US6860895B1 (en) * 1999-06-18 2005-03-01 Radi Medical Systems Ab Tool, a sealing device, a system and a method for closing a wound
US6468291B2 (en) 1999-07-16 2002-10-22 Baff Llc Emboli filtration system having integral strut arrangement and methods of use
DE69939753D1 (en) 1999-08-27 2008-11-27 Ev3 Inc Sliding vascular filter
EP1210014A1 (en) 1999-09-07 2002-06-05 Microvena Corporation Retrievable septal defect closure device
US20010041914A1 (en) 1999-11-22 2001-11-15 Frazier Andrew G.C. Tissue patch deployment catheter
US6964674B1 (en) 1999-09-20 2005-11-15 Nuvasive, Inc. Annulotomy closure device
US6325815B1 (en) 1999-09-21 2001-12-04 Microvena Corporation Temporary vascular filter
US6652555B1 (en) 1999-10-27 2003-11-25 Atritech, Inc. Barrier device for covering the ostium of left atrial appendage
US6551303B1 (en) * 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US6689150B1 (en) 1999-10-27 2004-02-10 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6468303B1 (en) 2000-03-27 2002-10-22 Aga Medical Corporation Retrievable self expanding shunt
US6468301B1 (en) 2000-03-27 2002-10-22 Aga Medical Corporation Repositionable and recapturable vascular stent/graft
US6650923B1 (en) 2000-04-13 2003-11-18 Ev3 Sunnyvale, Inc. Method for accessing the left atrium of the heart by locating the fossa ovalis
US6551344B2 (en) * 2000-04-26 2003-04-22 Ev3 Inc. Septal defect occluder
CA2410971C (en) 2000-05-31 2007-12-18 Brian K. Courtney Embolization protection system for vascular procedures
USD466936S1 (en) 2000-06-07 2002-12-10 Gore Enterprise Holdings, Inc. Medical training device for a cardiac septal occluder
US6440152B1 (en) 2000-07-28 2002-08-27 Microvena Corporation Defect occluder release assembly and method
US6527746B1 (en) * 2000-08-03 2003-03-04 Ev3, Inc. Back-loading catheter
US6511496B1 (en) * 2000-09-12 2003-01-28 Advanced Cardiovascular Systems, Inc. Embolic protection device for use in interventional procedures
US6508828B1 (en) * 2000-11-03 2003-01-21 Radi Medical Systems Ab Sealing device and wound closure device
US6517551B1 (en) * 2000-11-22 2003-02-11 George Mark Driskill Intravascular foreign object retrieval catheter
US6746404B2 (en) * 2000-12-18 2004-06-08 Biosense, Inc. Method for anchoring a medical device between tissue
US6562058B2 (en) 2001-03-02 2003-05-13 Jacques Seguin Intravascular filter system
JP2005508201A (en) * 2001-03-08 2005-03-31 アトリテック, インコーポレイテッド Atrial filter implant
US20020161395A1 (en) 2001-04-03 2002-10-31 Nareak Douk Guide wire apparatus for prevention of distal atheroembolization
US7011671B2 (en) * 2001-07-18 2006-03-14 Atritech, Inc. Cardiac implant device tether system and method
US20030023266A1 (en) * 2001-07-19 2003-01-30 Borillo Thomas E. Individually customized atrial appendage implant device
US7288105B2 (en) 2001-08-01 2007-10-30 Ev3 Endovascular, Inc. Tissue opening occluder
WO2003022344A3 (en) * 2001-09-06 2003-07-31 Nmt Medical Inc Flexible delivery system
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
US7318833B2 (en) 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
EP1467661A4 (en) * 2001-12-19 2008-11-05 Nmt Medical Inc Septal occluder and associated methods
EP1471835A4 (en) 2002-01-14 2008-03-19 Nmt Medical Inc Patent foramen ovale (pfo) closure method and device
US20030139819A1 (en) 2002-01-18 2003-07-24 Beer Nicholas De Method and apparatus for closing septal defects
EP1469790B1 (en) * 2002-01-25 2016-10-19 Atritech, Inc. Atrial appendage blood filtration systems
EP1487353A4 (en) 2002-03-25 2008-04-16 Nmt Medical Inc Patent foramen ovale (pfo) closure clips
CA2488337A1 (en) 2002-06-05 2003-12-18 Nmt Medical, Inc. Patent foramen ovale (pfo) closure device with radial and circumferential support
EP1526810B1 (en) * 2002-07-31 2009-04-15 Abbott Laboratories Vascular Enterprises Limited Apparatus for sealing surgical punctures
WO2004026147A3 (en) * 2002-09-23 2004-08-12 Nmt Medical Inc Septal puncture device
EP1560525B1 (en) * 2002-11-07 2009-01-14 NMT Medical, Inc. Patent foramen ovale (pfo) closure with magnetic force
US9017373B2 (en) * 2002-12-09 2015-04-28 W.L. Gore & Associates, Inc. Septal closure devices
US6960220B2 (en) * 2003-01-22 2005-11-01 Cardia, Inc. Hoop design for occlusion device
US7087072B2 (en) * 2003-01-22 2006-08-08 Cardia, Inc. Articulated center post
US7115135B2 (en) * 2003-01-22 2006-10-03 Cardia, Inc. Occlusion device having five or more arms
US6960224B2 (en) * 2003-01-22 2005-11-01 Cardia, Inc. Laminated sheets for use in a fully retrievable occlusion device
US20040143294A1 (en) * 2003-01-22 2004-07-22 Cardia, Inc. Septal stabilization device
US7491212B2 (en) * 2003-02-19 2009-02-17 Smith & Nephew, Inc. Transmitting an actuating force along a curved instrument
US6939348B2 (en) 2003-03-27 2005-09-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
WO2004087235A3 (en) 2003-03-27 2005-01-06 Cierra Inc Methods and apparatus for treatment of patent foramen ovale
US7165552B2 (en) * 2003-03-27 2007-01-23 Cierra, Inc. Methods and apparatus for treatment of patent foramen ovale
US7293562B2 (en) 2003-03-27 2007-11-13 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US7186251B2 (en) * 2003-03-27 2007-03-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US8372112B2 (en) * 2003-04-11 2013-02-12 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods, and related methods of use
US20040267306A1 (en) 2003-04-11 2004-12-30 Velocimed, L.L.C. Closure devices, related delivery methods, and related methods of use
US7597704B2 (en) * 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
US6913614B2 (en) * 2003-05-08 2005-07-05 Cardia, Inc. Delivery system with safety tether
US7625364B2 (en) * 2003-05-27 2009-12-01 Cardia, Inc. Flexible center connection for occlusion device
ES2428967T3 (en) * 2003-07-14 2013-11-12 W.L. Gore & Associates, Inc. tubular closure device patent foramen ovale (PFO) retention system
US7735493B2 (en) * 2003-08-15 2010-06-15 Atritech, Inc. System and method for delivering a left atrial appendage containment device
CA2538707A1 (en) * 2003-09-11 2005-04-21 Nmt Medical, Inc. Suture sever tube
US7192435B2 (en) * 2003-09-18 2007-03-20 Cardia, Inc. Self centering closure device for septal occlusion
US7144410B2 (en) * 2003-09-18 2006-12-05 Cardia Inc. ASD closure device with self centering arm network
US7658748B2 (en) * 2003-09-23 2010-02-09 Cardia, Inc. Right retrieval mechanism
EP2213244A1 (en) 2003-10-24 2010-08-04 ev3 Endovascular, Inc. Patent foramen ovale closure system
US7666203B2 (en) 2003-11-06 2010-02-23 Nmt Medical, Inc. Transseptal puncture apparatus
US20050113868A1 (en) 2003-11-20 2005-05-26 Devellian Carol A. Device, with electrospun fabric, for a percutaneous transluminal procedure, and methods thereof
US7566336B2 (en) 2003-11-25 2009-07-28 Cardia, Inc. Left atrial appendage closure device

Patent Citations (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3638388A (en) * 1970-01-22 1972-02-01 Anthony J Crookston Method of applying shingles
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3638652A (en) * 1970-06-01 1972-02-01 James L Kelley Surgical instrument for intraluminal anastomosis
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US4007743A (en) * 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4083162A (en) * 1977-04-08 1978-04-11 Regan Joseph F Connector assembly
US4309776A (en) * 1980-05-13 1982-01-12 Ramon Berguer Intravascular implantation device and method of using the same
US4368736A (en) * 1980-11-17 1983-01-18 Kaster Robert L Anastomotic fitting
US4503569A (en) * 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
US4592754A (en) * 1983-09-09 1986-06-03 Gupte Pradeep M Surgical prosthetic vessel graft and catheter combination and method
US5597378A (en) * 1983-10-14 1997-01-28 Raychem Corporation Medical devices incorporating SIM alloy elements
US4665906A (en) * 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US5275622A (en) * 1983-12-09 1994-01-04 Harrison Medical Technologies, Inc. Endovascular grafting apparatus, system and method and devices for use therewith
US5397345A (en) * 1983-12-09 1995-03-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4739762A (en) * 1985-11-07 1988-04-26 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4739762B1 (en) * 1985-11-07 1998-10-27 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4733665A (en) * 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4733665B1 (en) * 1985-11-07 1994-01-11 Expandable Grafts Partnership Expandable intraluminal graft,and method and apparatus for implanting an expandable intraluminal graft
US4649922A (en) * 1986-01-23 1987-03-17 Wiktor Donimik M Catheter arrangement having a variable diameter tip and spring prosthesis
US5104399A (en) * 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US4748982A (en) * 1987-01-06 1988-06-07 Advanced Cardiovascular Systems, Inc. Reinforced balloon dilatation catheter with slitted exchange sleeve and method
US4826487A (en) * 1987-05-04 1989-05-02 Victory Engineering Company Alignment button for stereotaxic plug and method of using the same
US4836204A (en) * 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
US4832055A (en) * 1988-07-08 1989-05-23 Palestrant Aubrey M Mechanically locking blood clot filter
US4921484A (en) * 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US4917089A (en) * 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US5190536A (en) * 1988-11-08 1993-03-02 Health Research, Inc. Submersible lens fiberoptic assembly for use in PDT treatment
US5192301A (en) * 1989-01-17 1993-03-09 Nippon Zeon Co., Ltd. Closing plug of a defect for medical use and a closing plug device utilizing it
US5207695A (en) * 1989-06-19 1993-05-04 Trout Iii Hugh H Aortic graft, implantation device, and method for repairing aortic aneurysm
US5078736A (en) * 1990-05-04 1992-01-07 Interventional Thermodynamics, Inc. Method and apparatus for maintaining patency in the body passages
US5098440A (en) * 1990-08-14 1992-03-24 Cordis Corporation Object retrieval method and apparatus
US5385562A (en) * 1990-10-29 1995-01-31 Scimed Life Systems, Inc. Guide catheter system for an angioplasty balloon catheter
US5108420A (en) * 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5489295A (en) * 1991-04-11 1996-02-06 Endovascular Technologies, Inc. Endovascular graft having bifurcation and apparatus and method for deploying the same
US5284486A (en) * 1991-06-11 1994-02-08 Microvena Corporation Self-centering mechanical medical device
US5304220A (en) * 1991-07-03 1994-04-19 Maginot Thomas J Method and apparatus for implanting a graft prosthesis in the body of a patient
US5211683A (en) * 1991-07-03 1993-05-18 Maginot Thomas J Method of implanting a graft prosthesis in the body of a patient
US5387235A (en) * 1991-10-25 1995-02-07 Cook Incorporated Expandable transluminal graft prosthesis for repair of aneurysm
US5211658A (en) * 1991-11-05 1993-05-18 New England Deaconess Hospital Corporation Method and device for performing endovascular repair of aneurysms
US5176692A (en) * 1991-12-09 1993-01-05 Wilk Peter J Method and surgical instrument for repairing hernia
US5316023A (en) * 1992-01-08 1994-05-31 Expandable Grafts Partnership Method for bilateral intra-aortic bypass
US5486193A (en) * 1992-01-22 1996-01-23 C. R. Bard, Inc. System for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
US5391156A (en) * 1992-06-30 1995-02-21 Ethicon, Inc. Flexible encoscopic surgical port
US5496365A (en) * 1992-07-02 1996-03-05 Sgro; Jean-Claude Autoexpandable vascular endoprosthesis
US5904680A (en) * 1992-09-25 1999-05-18 Ep Technologies, Inc. Multiple electrode support structures having optimal bio-mechanical characteristics
US5304184A (en) * 1992-10-19 1994-04-19 Indiana University Foundation Apparatus and method for positive closure of an internal tissue membrane opening
US5417699A (en) * 1992-12-10 1995-05-23 Perclose Incorporated Device and method for the percutaneous suturing of a vascular puncture site
US5284488A (en) * 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
US5735290A (en) * 1993-02-22 1998-04-07 Heartport, Inc. Methods and systems for performing thoracoscopic coronary bypass and other procedures
US20020026094A1 (en) * 1993-02-22 2002-02-28 Roth Alex T. Devices for less-invasive intracardiac interventions
US5306234A (en) * 1993-03-23 1994-04-26 Johnson W Dudley Method for closing an atrial appendage
US5607444A (en) * 1993-12-02 1997-03-04 Advanced Cardiovascular Systems, Inc. Ostial stent for bifurcations
US5490856A (en) * 1993-12-14 1996-02-13 Untied States Surgical Corporation Purse string stapler
US6368339B1 (en) * 1994-07-08 2002-04-09 Aga Medical Corporation Method of forming medical devices: intra-vascular occlusion devices
US5725552A (en) * 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5397355A (en) * 1994-07-19 1995-03-14 Stentco, Inc. Intraluminal stent
US5618311A (en) * 1994-09-28 1997-04-08 Gryskiewicz; Joseph M. Surgical subcuticular fastener system
US5507769A (en) * 1994-10-18 1996-04-16 Stentco, Inc. Method and apparatus for forming an endoluminal bifurcated graft
US5891558A (en) * 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US6171329B1 (en) * 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US5614204A (en) * 1995-01-23 1997-03-25 The Regents Of The University Of California Angiographic vascular occlusion agents and a method for hemostatic occlusion
US5709224A (en) * 1995-06-07 1998-01-20 Radiotherapeutics Corporation Method and device for permanent vessel occlusion
US5865791A (en) * 1995-06-07 1999-02-02 E.P. Technologies Inc. Atrial appendage stasis reduction procedure and devices
US6021340A (en) * 1995-06-07 2000-02-01 Cardima, Inc. Guiding catheter for the coronary sinus
US5725568A (en) * 1995-06-27 1998-03-10 Scimed Life Systems, Inc. Method and device for recanalizing and grafting arteries
US5709707A (en) * 1995-10-30 1998-01-20 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US5749894A (en) * 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
US20010000797A1 (en) * 1996-01-24 2001-05-03 Microvena Corporation Method and apparatus for occluding aneurysms
US6168622B1 (en) * 1996-01-24 2001-01-02 Microvena Corporation Method and apparatus for occluding aneurysms
US6355052B1 (en) * 1996-02-09 2002-03-12 Pfm Produkte Fur Die Medizin Aktiengesellschaft Device for closure of body defect openings
US5885258A (en) * 1996-02-23 1999-03-23 Memory Medical Systems, Inc. Medical instrument with slotted memory metal tube
US5733294A (en) * 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
US6024756A (en) * 1996-03-22 2000-02-15 Scimed Life Systems, Inc. Method of reversibly closing a septal defect
US5906207A (en) * 1996-04-04 1999-05-25 Merck & Co., Inc. Method for simulating heart failure
US5904703A (en) * 1996-05-08 1999-05-18 Bard Connaught Occluder device formed from an open cell foam material
US5617878A (en) * 1996-05-31 1997-04-08 Taheri; Syde A. Stent and method for treatment of aortic occlusive disease
US6036716A (en) * 1996-07-09 2000-03-14 Kruchinin; Boris Petrovich Micro-surgery fixation device, variants manipulation push-bar for mounting the same
US5741297A (en) * 1996-08-28 1998-04-21 Simon; Morris Daisy occluder and method for septal defect repair
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US6391044B1 (en) * 1997-02-03 2002-05-21 Angioguard, Inc. Vascular filter system
US6026814A (en) * 1997-03-06 2000-02-22 Scimed Life Systems, Inc. System and method for percutaneous coronary artery bypass
US6035856A (en) * 1997-03-06 2000-03-14 Scimed Life Systems Percutaneous bypass with branching vessel
US6036702A (en) * 1997-04-23 2000-03-14 Vascular Science Inc. Medical grafting connectors and fasteners
US6174322B1 (en) * 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US5868762A (en) * 1997-09-25 1999-02-09 Sub-Q, Inc. Percutaneous hemostatic suturing device and method
US20020042625A1 (en) * 1997-09-26 2002-04-11 Stack Richard S. Perfusion-occlusion apparatus and methods
US6013190A (en) * 1998-01-21 2000-01-11 Vascular Science Inc. Catheters with integrated lumen and methods of their manufacture and use
US6193734B1 (en) * 1998-01-23 2001-02-27 Heartport, Inc. System for performing vascular anastomoses
US6210338B1 (en) * 1998-08-21 2001-04-03 Aga Medical Corp. Sizing catheter for measuring cardiovascular structures
US6368338B1 (en) * 1999-03-05 2002-04-09 Board Of Regents, The University Of Texas Occlusion method and apparatus
US6206907B1 (en) * 1999-05-07 2001-03-27 Cardia, Inc. Occlusion device with stranded wire support arms
US6379368B1 (en) * 1999-05-13 2002-04-30 Cardia, Inc. Occlusion device with non-thrombogenic properties
US6231561B1 (en) * 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6371971B1 (en) * 1999-11-15 2002-04-16 Scimed Life Systems, Inc. Guidewire filter and methods of use
US6214029B1 (en) * 2000-04-26 2001-04-10 Microvena Corporation Septal defect occluder
US20020029061A1 (en) * 2000-05-17 2002-03-07 Aga Medical Corp. Alignment member for delivering a non-symmetrical device with a predefined orientation
US6334864B1 (en) * 2000-05-17 2002-01-01 Aga Medical Corp. Alignment member for delivering a non-symmetric device with a predefined orientation
US20020022860A1 (en) * 2000-08-18 2002-02-21 Borillo Thomas E. Expandable implant devices for filtering blood flow from atrial appendages
US20020035374A1 (en) * 2000-09-21 2002-03-21 Borillo Thomas E. Apparatus for implanting devices in atrial appendages
US7338514B2 (en) * 2001-06-01 2008-03-04 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9943670B2 (en) 2001-04-20 2018-04-17 V-Wave Ltd. Methods and apparatus for reducing localized circulatory system pressure
US20110218481A1 (en) * 2001-04-20 2011-09-08 Dan Rottenberg Device and method for controlling in-vivo pressure
US20110218477A1 (en) * 2001-04-20 2011-09-08 V- Wave Ltd., Methods and apparatus for reducing localized circulatory system pressure
US8235933B2 (en) 2001-04-20 2012-08-07 V-Wave Ltd. Methods and apparatus for reducing localized circulatory system pressure
US9724499B2 (en) 2001-04-20 2017-08-08 V-Wave Ltd. Device and method for controlling in-vivo pressure
US8328751B2 (en) 2001-04-20 2012-12-11 V-Wave Ltd. Methods and apparatus for reducing localized circulatory system pressure
US8777985B2 (en) 2001-06-01 2014-07-15 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
US20080234702A1 (en) * 2002-06-13 2008-09-25 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20080294177A1 (en) * 2002-06-13 2008-11-27 Guided Delivery Systems Inc. Methods and devices for termination
US20060122633A1 (en) * 2002-06-13 2006-06-08 John To Methods and devices for termination
US20080045977A1 (en) * 2002-06-13 2008-02-21 John To Methods and devices for termination
US9072513B2 (en) 2002-06-13 2015-07-07 Guided Delivery Systems Inc. Methods and devices for termination
US7883538B2 (en) 2002-06-13 2011-02-08 Guided Delivery Systems Inc. Methods and devices for termination
US8287557B2 (en) 2002-06-13 2012-10-16 Guided Delivery Systems, Inc. Methods and devices for termination
US20060190030A1 (en) * 2002-06-13 2006-08-24 John To Methods and devices for termination
US20080051837A1 (en) * 2002-06-13 2008-02-28 John To Methods and devices for termination
US8066766B2 (en) 2002-06-13 2011-11-29 Guided Delivery Systems Inc. Methods and devices for termination
US8382796B2 (en) 2003-04-11 2013-02-26 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and related methods of use
US20070282157A1 (en) * 2004-02-03 2007-12-06 Atria Medical Inc. Device And Method For Controlling In-Vivo Pressure
US8070708B2 (en) 2004-02-03 2011-12-06 V-Wave Limited Device and method for controlling in-vivo pressure
US20150039084A1 (en) * 2006-01-23 2015-02-05 Tamir Levi Heart Anchor Device
US9681948B2 (en) * 2006-01-23 2017-06-20 V-Wave Ltd. Heart anchor device
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
US20080172035A1 (en) * 2006-10-18 2008-07-17 Starksen Niel F Methods and devices for catheter advancement and delivery of substances therethrough
US9636106B2 (en) 2008-10-10 2017-05-02 Ancora Heart, Inc. Termination devices and related methods
US8795298B2 (en) 2008-10-10 2014-08-05 Guided Delivery Systems Inc. Tether tensioning devices and related methods
US20100185172A1 (en) * 2009-01-20 2010-07-22 Mariel Fabro Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods
US20100198208A1 (en) * 2009-01-20 2010-08-05 Napp Malte I Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods
US20100198056A1 (en) * 2009-01-20 2010-08-05 Mariel Fabro Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods
US9173646B2 (en) 2009-01-20 2015-11-03 Guided Delivery Systems Inc. Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods
US8029534B2 (en) 2009-03-16 2011-10-04 Cook Medical Technologies Llc Closure device with string retractable umbrella
US20100234878A1 (en) * 2009-03-16 2010-09-16 Cook Incorporated Closure device with string retractable umbrella
US8277482B2 (en) 2009-03-16 2012-10-02 Cook Medical Technologies Llc Closure device with string retractable umbrella and method for closing a body opening with the same
US8696611B2 (en) 2009-05-04 2014-04-15 V-Wave Ltd. Device and method for regulating pressure in a heart chamber
US9980815B2 (en) 2009-05-04 2018-05-29 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
US9707382B2 (en) 2009-05-04 2017-07-18 V-Wave Ltd. Device and method for regulating pressure in a heart chamber
US10076403B1 (en) 2009-05-04 2018-09-18 V-Wave Ltd. Shunt for redistributing atrial blood volume
US20120172931A1 (en) * 2009-06-21 2012-07-05 Aesthetics Point Ltd. implanted medical device useful for cosmetic surgery
US9050078B2 (en) * 2009-06-21 2015-06-09 Aesthetics Point Ltd. Implanted medical device useful for cosmetic surgery
US9034034B2 (en) 2010-12-22 2015-05-19 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
US9629715B2 (en) 2011-07-28 2017-04-25 V-Wave Ltd. Devices for reducing left atrial pressure having biodegradable constriction, and methods of making and using same
US9713696B2 (en) 2013-05-21 2017-07-25 V-Wave Ltd. Apparatus and methods for delivering devices for reducing left atrial pressure
US10058321B2 (en) 2015-03-05 2018-08-28 Ancora Heart, Inc. Devices and methods of visualizing and determining depth of penetration in cardiac tissue
US10092402B2 (en) 2016-09-14 2018-10-09 Ancora Heart, Inc. Devices and methods for heart valve repair

Also Published As

Publication number Publication date Type
WO2004091411A3 (en) 2005-01-06 application
US20040267306A1 (en) 2004-12-30 application
US20100069954A1 (en) 2010-03-18 application
US20070066994A1 (en) 2007-03-22 application
US20070016250A1 (en) 2007-01-18 application
WO2004091411A2 (en) 2004-10-28 application
EP1620017A2 (en) 2006-02-01 application
EP1620017B1 (en) 2011-07-13 grant
JP2006522652A (en) 2006-10-05 application
US8574264B2 (en) 2013-11-05 grant
JP4827728B2 (en) 2011-11-30 grant
US8382796B2 (en) 2013-02-26 grant

Similar Documents

Publication Publication Date Title
US5924424A (en) Method and apparatus for thoracoscopic intracardiac procedures
US5846261A (en) Percutaneous catheter directed occlusion devices
US6221092B1 (en) Closure device for transcatheter operations and catheter assembly therefor
US7293562B2 (en) Energy based devices and methods for treatment of anatomic tissue defects
US7431729B2 (en) Patent foramen ovale (PFO) closure device with radial and circumferential support
US7097653B2 (en) Implant for the closing of defect openings in the body of a human or animal and a system for the placement of such an implant
US7549983B2 (en) Method of closing an opening in a wall of the heart
US7022131B1 (en) Methods and devices for vascular surgery
US7220265B2 (en) Patent foramen ovale (PFO) closure method and device
US20090222083A1 (en) Multi-window guide tunnel
US20070123852A1 (en) Methods and apparatus for closing a layered tissue defect
US20010041914A1 (en) Tissue patch deployment catheter
US20110087247A1 (en) Tissue ligation devices and controls therefor
US20050075665A1 (en) Apparatus and methods for tissue gathering and securing
US20070123934A1 (en) Delivery system for patent foramen ovale closure device
US20060217764A1 (en) Systems and Methods for Treating Septal Defects
US7846179B2 (en) Suture-based systems and methods for treating septal defects
US20060009799A1 (en) Embolic filtering method and apparatus
US6702835B2 (en) Needle apparatus for closing septal defects and methods for using such apparatus
EP1904217B1 (en) Embolic filtering method and apparatus
US20070032820A1 (en) Patent foramen ovale closure device
US20070167981A1 (en) Catch members for occluder devices
US7678123B2 (en) Tubular patent foramen ovale (PFO) closure device with catch system
US20070250081A1 (en) Adjustable length patent foramen ovale (PFO) occluder and catch system
US20070010851A1 (en) Tubular patent foramen ovale (PFO) closure device with catch system

Legal Events

Date Code Title Description
AS Assignment

Owner name: VELOCIMED PFO, INC., MINNESOTA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:VELOCIMED, LLC;REEL/FRAME:024741/0195

Effective date: 20030619

AS Assignment

Owner name: ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC., MINNE

Free format text: MERGER;ASSIGNOR:VELOCIMED PFO. INC.;REEL/FRAME:024751/0024

Effective date: 20051221

Owner name: ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC., MINNE

Free format text: MERGER;ASSIGNOR:VELOCIMED PFO, INC.;REEL/FRAME:024751/0024

Effective date: 20051221

AS Assignment

Owner name: VELOCIMED, L.L.C., MINNESOTA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BLAESER, DAVID J.;GRUDEM JR., JEROME K.;OLSON, SCOTT A.;AND OTHERS;SIGNING DATES FROM 20030409 TO 20030410;REEL/FRAME:024764/0278