US20060178738A1 - Coated endovascular stent - Google Patents

Coated endovascular stent Download PDF

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US20060178738A1
US20060178738A1 US11398826 US39882606A US2006178738A1 US 20060178738 A1 US20060178738 A1 US 20060178738A1 US 11398826 US11398826 US 11398826 US 39882606 A US39882606 A US 39882606A US 2006178738 A1 US2006178738 A1 US 2006178738A1
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Prior art keywords
heparin
stent
coating
structure
support
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Abandoned
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US11398826
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John Yan
Randy Chan
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Yan John Y
Randy Chan
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005Use of materials characterised by their function or physical properties
    • A61L33/0011Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077Special surfaces of prostheses, e.g. for improving ingrowth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/92Stents in the form of a rolled-up sheet expanding after insertion into the vessel, e.g. with a spiral shape in cross-section
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/072Encapsulated stents, e.g. wire or whole stent embedded in lining
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/075Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2420/00Materials or methods for coatings medical devices
    • A61L2420/08Coatings comprising two or more layers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92Method or apparatus for preparing or treating prosthetic
    • Y10S623/921Blood vessel

Abstract

An implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is first implanted and then exposed to heparinized blood. As heparin becomes detached from the stent, the implantation site is exposed to heparin to restore an effective level and thereby prevent thrombosis.

Description

    CROSS REFERENCE
  • [0001]
    This is a divisional application of application Ser. No. 10/877,527 filed on Jun. 24, 2004, which is a divisional application of application Ser. No. 08/847,763 filed on Apr. 24, 1997, now U.S. Pat. No. 6,776,792.
  • BACKGROUND OF THE INVENTION
  • [0002]
    The present invention relates to endovascular stents and more particularly pertains to coatings that are applied to stents in order to reduce thrombogenicity.
  • [0003]
    Stents are implanted within blood vessels in an effort to maintain their patency by preventing collapse of the lumen and/or by impeding restenosis. Unfortunately, the presence of a foreign object within the blood flow may have a thrombogenic effect. It has therefore been found to be desirable to use various anti-coagulant drugs in an effort to reduce the likelihood of the development of restenosis and provide an antithrombogenic effect.
  • [0004]
    A drug that has been found to be particularly effective for such purpose is heparin. By maintaining an effective concentration of the drug in and about the implantation site until the stent is encapsulated by tissue, the risk of thrombogenesis is substantially mitigated. To that end, various approaches have been employed in the administration of heparin.
  • [0005]
    While the systemic administration of heparin can cause the implantation site to be subjected to an effective level of heparin, such level of heparin would necessarily also be present throughout the rest of the body which can lead to undesirable side effects such as bleeding. It has therefore been recognized that a regimen wherein the heparin is substantially constrained to the implantation site is far more desirable. An approach that has been devised to achieve such end requires the coating or impregnation of the stent itself with heparin. The heparin is thereby concentrated where it is most needed while its presence, and consequently its effect, throughout the rest of the body is minimized.
  • [0006]
    Disadvantages associated with heretofore known heparinized stents include, the limited shelf life of such devices, the fact the heparin is degraded when the stent is sterilized either by heat or by exposure to ethylene dioxide, the inability of the physician to alter the dosage that the patient is subjected to and the inability to replenish any heparin that may be lost while the device is deployed. Additionally, the cost of heretofore known heparinized stent devices has been very high as it necessarily includes the costs associated with the stringent regulatory requirements attendant a drug containing device.
  • [0007]
    The prior art has been unable to overcome these disadvantages and shortcomings and a new approach is needed to safely, effectively, and economically deliver heparin to an implantation site.
  • SUMMARY OF THE INVENTION
  • [0008]
    The present invention provides for the coating of an implantable endovascular device to facilitate the subsequent loading of heparin onto its surface. Such loading can be achieved in vitro just prior to implantation or preferably, in vivo after the device is in place. As a result, the device has a considerably longer shelf-life than heparin-containing devices, the need for special handling and sterilization procedures associated with heparin-containing devices is obviated, and the dosage of heparin can be readily tailored to an individual patient's needs including any adjustment that may be required after the device has been deployed. An additional advantage provided by such a device is that it is not subject to the stringent regulatory requirements associated with drug-containing devices.
  • [0009]
    More particularly, the present invention provides for the coating of stent surfaces with a material or combination of materials that are selected for their ability to adhere to the stent surface, to attract heparin and to form preferably an ionic bond therewith. The heparin is attracted by and attaches to functional groups incorporated in the coating which may include primary, secondary, and/or tertiary amines or other functionalities such as carboxyl groups.
  • [0010]
    The heparin-attracting coating may be applied so as to encapsulate the entire stent or alternatively, to cover only selected surfaces thereof. By limiting coverage to only the inner surface of the stent, i.e., the surface that is directly exposed to blood flow, a much higher level of heparin can be loaded onto the stent than would be safe if such level were in direct contact with the vessel wall. A toxic effect on the vessel wall is thereby avoided while the blood is exposed to a more effective concentration of heparin. Alternatively, it may be deemed sufficient to coat only the ends of the stent, i.e., where disturbance of flow is greatest and where thromboses are most likely to occur.
  • [0011]
    The coating may be applied by different processes such as by dipping, spraying or molding. The preferred method is by plasma deposition wherein a base layer, selected for its ability to adhere to the stent surface, is first deposited on the stent followed by the deposition of a top layer thereon that is selected for its ability to bond to the base layer and to avail the appropriate functional groups for bonding to the heparin.
  • [0012]
    These and other features and advantages of the present invention will become apparent from the following detailed description which, taken in conjunction with the accompanying drawings, illustrates by way of example the principles of the invention.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0013]
    FIG. 1 is a perspective view of an implantable stent.
  • [0014]
    FIG. 2 is a greatly enlarged, schematic, cross-sectional view of a portion of the stent of the present invention.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • [0015]
    A wide variety of different stent configurations have been devised to address various issues inherent in their use and function. Additionally, various materials have been employed in their construction including metals and polymers. Both the degree of turbulence caused by a particular stent configuration when subjected to blood flow as well as the material from which it is constructed affects the degree of thrombogenicity associated with a particular stent device. The present invention provides a coating for such stents to which heparin becomes attached and thus serves to reduce or eliminate thrombosis formation. Moreover, the stent's coating allows the heparin to be loaded thereon immediately before the implantation procedure or after the stent is in place.
  • [0016]
    Critical requirements for the coating of the present invention include that it adheres to the stent surface and that it has functional groups that attract heparin and to which heparin bonds. Functional groups that are known to have the requisite affinity for heparin include primary, secondary, and tertiary amines wherein primary amines are preferred due to their enhanced affinity. Alternatively, carboxyl groups may be used. The functional groups must include positively charged entities that serve to attract the negatively charged entities associated with the heparin. Such attraction facilitates the formation of an ionic bond.
  • [0017]
    The coating can be applied by different processes such as by dipping, spraying, molding or by plasma deposition. Plasma deposition is preferred and first requires the deposition of a base layer or primer that prepares the surface of the stent to receive the functionality group containing substance. In the preferred embodiment, a metallic stent is first plasma deposited with methane gas leaving a film on the surface of the stent wherein the methane molecules are oriented with the carbon against the stent and the hydrogen exposed. A top layer that includes the desired functionalities is then deposited on the base layer. Such second layer may be formed by the plasma deposition of ammonia gas to leave the primary amine functional groups extending from the stent surface. Other chemicals such as alkylamine, nitrile compounds or amine containing monomers can also be used to plasma deposit amine functionalities on the surface. In the event a mixture of primary, secondary, and tertiary amines is deposited by such methods it is preferred that the primary amine constitutes a greater percentage of the mixture due to its greater affinity for heparin. Alternatively, the deposition of carboxyl functional groups can be achieved by the plasma deposition of monomers like methyl methacrylate or acrylic acid.
  • [0018]
    The resulting coating thickness should be 0.001 inch or less while a thickness less than 1 micron is preferred. Although it may be desirable to have a uniform concentration of functional groups extending from the surface, it is not critical to the function of the coating. On the other hand, a concentration of at least 54 picamoles/stent must be achieved in order to ensure that heparin becomes attached at an effective level.
  • [0019]
    The coating may be applied to the entire stent or just to selected surfaces thereon. FIG. 1 generally illustrates a stent 12 in its deployed state and serves to identify the vessel wall-facing surface 14, the blood flow-facing surface 16, its upstream edge 18, and its downstream edge 20. By coating only the surfaces facing the blood flow, a concentration of heparin can be loaded thereon that would be toxic to the vessel wall tissue if it were to be present on the surfaces in direct contact with the vessel wall. Alternatively, it may be sufficient to exclusively coat the upstream and/or downstream edges of the stent for a particular stent configuration implanted in a particular patient as thrombosis is most likely to occur at such interfaces due to turbulence induced by their presence in the blood flow.
  • [0020]
    After the coating process is completed, the coated stent is cleaned and sterilized and appropriately packaged for long-term storage. Due to the absence of any degradable drugs or substances on the stent, a fairly extended shelf-life can be expected.
  • [0021]
    The stent of the present invention can be used in two different ways. A first use calls for the stent to be implanted in the form in which it had been stored, without having heparin loaded thereon. Once in place, it is contacted with heparinized blood, either by an injection of heparin via a catheter extended to a position just upstream of the implantation site or by IV. As the heparin macromolecules 22 pass by the functional groups 24 in the coating 26, the heparin is attracted thereto and becomes attached (FIG. 2). Heparin that does not attach, quickly becomes diluted downstream of the implantation site to levels that do not adversely affect the patient. Subsequent heparin flow past the implantation site can cause more and more heparin molecules to be pulled from the blood flow until the stent coating is saturated. Once attached, heparin can inhibit coagulation by binding with anti-thrombin III and/or other factors of the coagulation cascade. Should a heparin molecule become detached, it is replaced by other heparin molecules still present in the blood flow. Alternatively, an additional dosage of heparin can be administered.
  • [0022]
    Alternatively, the physician may pre-treat the stent prior to implantation by flushing it with, for example, a heparinized saline solution. In this way, the physician can easily and precisely adjust the heparin level by controlling the concentration of the heparin in the saline solution and/or controlling the exposure time thereto. Once implanted, the heparin level can be increased or replenished by introducing heparin into the blood flow upstream of the implantation site as was described above. The heparin level is maintained on the stent until the natural healing processes cause the stent surfaces to be completely covered by tissue at which point thrombogenicity ceases to be of concern.
  • [0023]
    While a particular form of the invention has been illustrated and described, it will also be apparent to those skilled in the art that various modifications can be made without departing from the spirit and scope of the invention. Accordingly, it is not intended that the invention be limited except by the appended claims.

Claims (22)

  1. 1. A method of making a medical device comprising:
    providing an implantable support structure;
    depositing a coating on the support structure, the coating including functional groups that attract heparin;
    implanting the support structure in the patient's vasculature; and
    exposing the implanted support structure to heparinized blood such that heparin attaches to the coating.
  2. 2. The method of claim 1, wherein heparin attaches to the coating via ionic bonds.
  3. 3. The method of claim 1, wherein exposing the implantable support structure to heparinized blood comprises delivering heparin from a catheter to the patient.
  4. 4. The method of claim 1, wherein the coating is deposited on the entire support structure.
  5. 5. The method of claim 1, wherein the support structure is configured such that upon implantation in a blood vessel, such support structure has surfaces that face the vessel walls and surfaces that face the blood flow and wherein the coating is exclusively deposited on the surfaces that face the blood flow.
  6. 6. The method of claim 1, wherein the support structure is configured such that upon implantation in a blood vessel, such support structure has surfaces that face the vessel walls, surfaces that face the blood flow and an upstream edge and a downstream edge and wherein the coating is exclusively deposited on at least one of the edges.
  7. 7. The method of claim 1, wherein the coating is deposited on the support structure by dipping, spraying or molding.
  8. 8. The method of claim 1, wherein the coating is deposited on the support structure by plasma deposition.
  9. 9. The method of claim 1, wherein the coating is deposited by first depositing a base layer, selected for its ability to adhere to the support structure and then depositing thereon a top layer selected for its ability to bond to the base layer and avail the functional groups for attachment to the heparin.
  10. 10. The method of claim 1, further comprising repeatedly exposing the implanted support structure to heparinized blood in order to maintain a heparin level on the stent.
  11. 11. The method of claim 1, wherein the functional groups are selected from a group consisting of amine and carboxyl groups.
  12. 12. A method of making a medical device, comprising:
    providing an implantable support structure;
    depositing a coating on the support structure, the coating including functional groups that attract heparin, bond with heparin, or a combination thereof,
    when the coating is exposed to heparin;
    sterilizing and storing the support structure having the coating deposited thereon;
    exposing the coated support structure to a heparin-containing solution; and
    implanting the structure in the patient's vasculature.
  13. 13. The method of claim 12, wherein the coating is deposited on the entire support structure.
  14. 14. The method of claim 12, wherein the support structure is configured such that upon implantation in a blood vessel, such support structure has surfaces that face the vessel walls and surfaces that face the blood flow and wherein the coating is exclusively deposited on the surfaces that face the blood flow.
  15. 15. The method of claim 12, wherein the support structure is configured such that upon implantation in a blood vessel, such support structure has surfaces that face the vessel walls, surfaces that face the blood flow and an upstream edge and a downstream edge and wherein the coating is exclusively deposited on at least one of the edges.
  16. 16. The method of claim 12, wherein the coating is deposited on the support structure by dipping, spraying or molding.
  17. 17. The method of claim 12, wherein the coating is deposited on the support structure by plasma deposition.
  18. 18. The method of claim 12, wherein the coating is deposited by first depositing a base layer, selected for its ability to adhere to the support structure and then depositing thereon a top layer selected for its ability to bond to the base layer and avail the functional groups for attachment to the heparin.
  19. 19. The method of claim 12, further comprising exposing the implanted support structure to heparinized blood in order to maintain a heparin level on the support structure.
  20. 20. The method of claim 12, wherein the functional groups are selected from a group consisting of amine and carboxyl groups.
  21. 21. The method of claim 12, wherein the bonding of the coating with heparin comprises a combination of ionic bonding and covalent bonding.
  22. 22. The method of claim 12, wherein the support structure comprises a stent.
US11398826 1997-04-24 2006-04-05 Coated endovascular stent Abandoned US20060178738A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US08847763 US6776792B1 (en) 1997-04-24 1997-04-24 Coated endovascular stent
US10877527 US7077860B2 (en) 1997-04-24 2004-06-24 Method of reducing or eliminating thrombus formation
US11398826 US20060178738A1 (en) 1997-04-24 2006-04-05 Coated endovascular stent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11398826 US20060178738A1 (en) 1997-04-24 2006-04-05 Coated endovascular stent

Related Parent Applications (1)

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US10877527 Division US7077860B2 (en) 1997-04-24 2004-06-24 Method of reducing or eliminating thrombus formation

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US20060178738A1 true true US20060178738A1 (en) 2006-08-10

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US08847763 Active 2018-12-09 US6776792B1 (en) 1997-04-24 1997-04-24 Coated endovascular stent
US09430230 Expired - Lifetime US6605114B1 (en) 1997-04-24 1999-10-29 Heparin delivery method
US10877527 Expired - Lifetime US7077860B2 (en) 1997-04-24 2004-06-24 Method of reducing or eliminating thrombus formation
US11398826 Abandoned US20060178738A1 (en) 1997-04-24 2006-04-05 Coated endovascular stent

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US08847763 Active 2018-12-09 US6776792B1 (en) 1997-04-24 1997-04-24 Coated endovascular stent
US09430230 Expired - Lifetime US6605114B1 (en) 1997-04-24 1999-10-29 Heparin delivery method
US10877527 Expired - Lifetime US7077860B2 (en) 1997-04-24 2004-06-24 Method of reducing or eliminating thrombus formation

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US (4) US6776792B1 (en)
EP (1) EP0873732B1 (en)
JP (1) JP3000076B2 (en)
DE (2) DE69801459D1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090299463A1 (en) * 2001-11-30 2009-12-03 Advanced Cardiovascular Systems, Inc. Modified Surface For An Implantable Device And A Method Of Producing The Same
US20100173065A1 (en) * 2001-07-30 2010-07-08 Advanced Cardiovascular Systems, Inc. Methods For Immobilizing Anti-Thrombogenic Material Onto A Medical Device Or Into A Coating Thereon
US8123799B1 (en) 2001-11-30 2012-02-28 Advanced Cardiovascular Systems, Inc. Modified implantable device surface and a method of making the same
US9561309B2 (en) 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174326B1 (en) 1996-09-25 2001-01-16 Terumo Kabushiki Kaisha Radiopaque, antithrombogenic stent and method for its production
US6776792B1 (en) * 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
US20090239940A1 (en) * 1997-07-22 2009-09-24 Del Monte Federica Treating heart failure and ventricular arrhythmias
US6560461B1 (en) 1997-08-04 2003-05-06 Mundi Fomukong Authorized location reporting paging system
FR2785812B1 (en) * 1998-11-16 2002-11-29 Commissariat Energie Atomique Prostheses bioactive such has immunosuppressive properties, antistenose and antithrombotic, and manufacturing
GB2347861B (en) * 1999-03-13 2003-11-26 Biointeractions Ltd Biocompatible endoprostheses
DE60013990D1 (en) 1999-08-05 2004-10-28 Sorin Biomedica Cardio Spa Stent for angioplasty
DE69934990D1 (en) 1999-11-23 2007-03-15 Sorin Biomedica Cardio Srl A method for transmitting radioactive substances on stents in angioplasty and kit
JP5000826B2 (en) 2000-01-24 2012-08-15 バイオコンパテイブルズ・ユーケイ・リミテツド The coated implant
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US7862495B2 (en) 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US6656216B1 (en) 2001-06-29 2003-12-02 Advanced Cardiovascular Systems, Inc. Composite stent with regioselective material
US7465298B2 (en) * 2002-06-28 2008-12-16 Mercator Medsystems, Inc. Methods and systems for delivering liquid substances to tissues surrounding body lumens
CA2503492A1 (en) * 2002-10-25 2004-05-06 Essentia Biosystems, Inc. Implantable medical devices using zinc
US20040093056A1 (en) 2002-10-26 2004-05-13 Johnson Lianw M. Medical appliance delivery apparatus and method of use
GB0225197D0 (en) * 2002-10-30 2002-12-11 Univ Sheffield Surface
US7959671B2 (en) 2002-11-05 2011-06-14 Merit Medical Systems, Inc. Differential covering and coating methods
US7875068B2 (en) 2002-11-05 2011-01-25 Merit Medical Systems, Inc. Removable biliary stent
US7637942B2 (en) 2002-11-05 2009-12-29 Merit Medical Systems, Inc. Coated stent with geometry determinated functionality and method of making the same
US9398967B2 (en) * 2004-03-02 2016-07-26 Syntach Ag Electrical conduction block implant device
EP1605866B1 (en) * 2003-03-03 2016-07-06 Syntach AG Electrical conduction block implant device
US8281737B2 (en) 2003-03-10 2012-10-09 Boston Scientific Scimed, Inc. Coated medical device and method for manufacturing the same
US7637934B2 (en) 2003-03-31 2009-12-29 Merit Medical Systems, Inc. Medical appliance optical delivery and deployment apparatus and method
US7291604B2 (en) * 2003-09-03 2007-11-06 The General Hospital Corporation Methods of treating restenosis
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
RU2372052C2 (en) * 2003-11-17 2009-11-10 Зинтах Аг Device, kit and method for treating disturbances of heart rhythm regulation system
DE102004018255A1 (en) * 2004-04-15 2005-11-10 Universitätsklinikum Schleswig-Holstein Vessel prosthesis for maintaining the air chamber function of large blood vessel systems, e.g. the aorta, comprises a tube having an inner wall provided with an elastic flexible lining
US7763065B2 (en) 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
WO2006042246A3 (en) * 2004-10-08 2006-11-30 Richard Cornelius Two-stage scar generation for treating atrial fibrillation
US7632307B2 (en) * 2004-12-16 2009-12-15 Advanced Cardiovascular Systems, Inc. Abluminal, multilayer coating constructs for drug-delivery stents
US8292944B2 (en) 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
KR100759130B1 (en) 2005-02-12 2007-09-19 장양수 Stent Coated with Anti-integrin Antibody and Process for Preparing the Same
US20060257355A1 (en) * 2005-05-10 2006-11-16 Abiomed, Inc. Impregnated polymer compositions and devices using them
US9149378B2 (en) 2005-08-02 2015-10-06 Reva Medical, Inc. Axially nested slide and lock expandable device
US7914574B2 (en) 2005-08-02 2011-03-29 Reva Medical, Inc. Axially nested slide and lock expandable device
US9101949B2 (en) 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US7896539B2 (en) 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US20070073377A1 (en) * 2005-09-27 2007-03-29 Mcdonald Michael B Method for placing a stent through a constricted lumen, and medical device
US20070083252A1 (en) * 2005-09-27 2007-04-12 Mcdonald Michael B Method for placing a stent through a constricted lumen, and medical device
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US9155641B2 (en) * 2006-03-09 2015-10-13 Cook Medical Technologies Llc Expandable stent grafts
US8069814B2 (en) 2006-05-04 2011-12-06 Advanced Cardiovascular Systems, Inc. Stent support devices
US8535368B2 (en) 2006-05-19 2013-09-17 Boston Scientific Scimed, Inc. Apparatus for loading and delivering a stent
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US8177798B2 (en) 2006-12-05 2012-05-15 Tyco Healthcare Group Lp Adhesive coated stent and insertion instrument
US7704275B2 (en) 2007-01-26 2010-04-27 Reva Medical, Inc. Circumferentially nested expandable device
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US20090011117A1 (en) * 2007-07-03 2009-01-08 Endotronix, Inc. Methods for texturing a surface of an endovascular implant
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US20100003828A1 (en) * 2007-11-28 2010-01-07 Guowen Ding Methods for adjusting critical dimension uniformity in an etch process with a highly concentrated unsaturated hydrocarbon gas
WO2009070180A1 (en) 2007-11-30 2009-06-04 Reva Medical, Inc. Axially-radially nested expandable device
CA2737753C (en) 2008-10-10 2017-03-14 Reva Medical, Inc. Expandable slide and lock stent
US20100106234A1 (en) * 2008-10-23 2010-04-29 Medtronic Vascular, Inc. Medical Devices With Extended Drug Diffusion Pathway
EP3138517A1 (en) * 2009-04-20 2017-03-08 Rox Medical, Inc. Device for establishing an artificial arterio-venous fistula
WO2011011433A1 (en) * 2009-07-20 2011-01-27 Boston Scientific Scimed, Inc. Medical device coating system
US8523936B2 (en) 2010-04-10 2013-09-03 Reva Medical, Inc. Expandable slide and lock stent
WO2012005614A1 (en) 2010-07-06 2012-01-12 Uniwersytet Jagielloński Multilayered protective coating for protecting metallic surfaces of implant materials and use thereof
US9408732B2 (en) 2013-03-14 2016-08-09 Reva Medical, Inc. Reduced-profile slide and lock stent
US9320592B2 (en) 2013-03-15 2016-04-26 Covidien Lp Coated medical devices and methods of making and using same
US9545301B2 (en) 2013-03-15 2017-01-17 Covidien Lp Coated medical devices and methods of making and using same
US9668890B2 (en) 2013-11-22 2017-06-06 Covidien Lp Anti-thrombogenic medical devices and methods
US9789228B2 (en) 2014-12-11 2017-10-17 Covidien Lp Antimicrobial coatings for medical devices and processes for preparing such coatings

Citations (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180632B2 (en) *
US2701559A (en) * 1951-08-02 1955-02-08 William A Cooper Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US4075045A (en) * 1976-02-09 1978-02-21 International Business Machines Corporation Method for fabricating FET one-device memory cells with two layers of polycrystalline silicon and fabrication of integrated circuits containing arrays of the memory cells charge storage capacitors utilizing five basic pattern deliberating steps
US4132357A (en) * 1976-06-23 1979-01-02 Inmont Corporation Apparatus and method for spray application of solvent-thinned coating compositions
US4633873A (en) * 1984-04-26 1987-01-06 American Cyanamid Company Surgical repair mesh
US4638805A (en) * 1985-07-30 1987-01-27 Advanced Cardiovascular Systems, Inc. Self-venting balloon dilatation catheter and method
US4718907A (en) * 1985-06-20 1988-01-12 Atrium Medical Corporation Vascular prosthesis having fluorinated coating with varying F/C ratio
US4722335A (en) * 1986-10-20 1988-02-02 Vilasi Joseph A Expandable endotracheal tube
US4723549A (en) * 1986-09-18 1988-02-09 Wholey Mark H Method and apparatus for dilating blood vessels
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4902289A (en) * 1982-04-19 1990-02-20 Massachusetts Institute Of Technology Multilayer bioreplaceable blood vessel prosthesis
US4988356A (en) * 1987-02-27 1991-01-29 C. R. Bard, Inc. Catheter and guidewire exchange system
US4994033A (en) * 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US4994298A (en) * 1988-06-07 1991-02-19 Biogold Inc. Method of making a biocompatible prosthesis
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
US5078720A (en) * 1990-05-02 1992-01-07 American Medical Systems, Inc. Stent placement instrument and method
US5081394A (en) * 1987-09-01 1992-01-14 Hitachi, Ltd. Black matrix color picture tube
US5084065A (en) * 1989-07-10 1992-01-28 Corvita Corporation Reinforced graft assembly
US5085629A (en) * 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US5087244A (en) * 1989-01-31 1992-02-11 C. R. Bard, Inc. Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen
US5087394A (en) * 1989-11-09 1992-02-11 Scimed Life Systems, Inc. Method for forming an inflatable balloon for use in a catheter
US5176638A (en) * 1990-01-12 1993-01-05 Don Michael T Anthony Regional perfusion catheter with improved drug delivery control
US5188734A (en) * 1991-03-26 1993-02-23 Memtec America Corporation Ultraporous and microporous integral membranes
US5275012A (en) * 1993-01-07 1994-01-04 Ford Motor Company Climate control system for electric vehicle
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US5278200A (en) * 1992-10-30 1994-01-11 Medtronic, Inc. Thromboresistant material and articles
US5279594A (en) * 1990-05-23 1994-01-18 Jackson Richard R Intubation devices with local anesthetic effect for medical use
US5282860A (en) * 1991-10-16 1994-02-01 Olympus Optical Co., Ltd. Stent tube for medical use
US5282823A (en) * 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5286254A (en) * 1990-06-15 1994-02-15 Cortrak Medical, Inc. Drug delivery apparatus and method
US5380299A (en) * 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
US5383925A (en) * 1992-09-14 1995-01-24 Meadox Medicals, Inc. Three-dimensional braided soft tissue prosthesis
US5383927A (en) * 1992-05-07 1995-01-24 Intervascular Inc. Non-thromogenic vascular prosthesis
US5385580A (en) * 1990-08-28 1995-01-31 Meadox Medicals, Inc. Self-supporting woven vascular graft
US5387450A (en) * 1989-05-11 1995-02-07 Landec Corporation Temperature-activated adhesive assemblies
US5389106A (en) * 1993-10-29 1995-02-14 Numed, Inc. Impermeable expandable intravascular stent
US5485496A (en) * 1994-09-22 1996-01-16 Cornell Research Foundation, Inc. Gamma irradiation sterilizing of biomaterial medical devices or products, with improved degradation and mechanical properties
US5591607A (en) * 1994-03-18 1997-01-07 Lynx Therapeutics, Inc. Oligonucleotide N3→P5' phosphoramidates: triplex DNA formation
US5591227A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Drug eluting stent
US5591199A (en) * 1995-06-07 1997-01-07 Porter; Christopher H. Curable fiber composite stent and delivery system
US5591224A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Bioelastomeric stent
US5593403A (en) * 1994-09-14 1997-01-14 Scimed Life Systems Inc. Method for modifying a stent in an implanted site
US5593434A (en) * 1992-01-31 1997-01-14 Advanced Cardiovascular Systems, Inc. Stent capable of attachment within a body lumen
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US5599307A (en) * 1993-07-26 1997-02-04 Loyola University Of Chicago Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities
US5599301A (en) * 1993-11-22 1997-02-04 Advanced Cardiovascular Systems, Inc. Motor control system for an automatic catheter inflation system
US5605696A (en) * 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US5707385A (en) * 1994-11-16 1998-01-13 Advanced Cardiovascular Systems, Inc. Drug loaded elastic membrane and method for delivery
US5711958A (en) * 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5711763A (en) * 1991-02-20 1998-01-27 Tdk Corporation Composite biological implant of a ceramic material in a metal substrate
US5711812A (en) * 1995-06-06 1998-01-27 Varian Associates, Inc. Apparatus for obtaining dose uniformity in plasma doping (PLAD) ion implantation processes
US5713949A (en) * 1996-08-06 1998-02-03 Jayaraman; Swaminathan Microporous covered stents and method of coating
US5716981A (en) * 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5718726A (en) * 1995-09-12 1998-02-17 Biotronik Mess- und Therapiegerate GmbH & Co Method of attaching heparin to, and immobilizing it on, inorganic substrate surfaces of cardiovascular implants
US5720726A (en) * 1992-12-30 1998-02-24 Medtronic, Inc. Balloon catheter having retention enhancements on the balloon
US5721131A (en) * 1987-03-06 1998-02-24 United States Of America As Represented By The Secretary Of The Navy Surface modification of polymers with self-assembled monolayers that promote adhesion, outgrowth and differentiation of biological cells
US5855612A (en) * 1995-05-12 1999-01-05 Ohta Inc. Biocompatible titanium implant
US5855598A (en) * 1993-10-21 1999-01-05 Corvita Corporation Expandable supportive branched endoluminal grafts
US5855618A (en) * 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
US5858990A (en) * 1997-03-04 1999-01-12 St. Elizabeth's Medical Center Fas ligand compositions for treatment of proliferative disorders
US5858556A (en) * 1997-01-21 1999-01-12 Uti Corporation Multilayer composite tubular structure and method of making
US5857998A (en) * 1994-06-30 1999-01-12 Boston Scientific Corporation Stent and therapeutic delivery system
US5858746A (en) * 1992-04-20 1999-01-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5860954A (en) * 1995-03-31 1999-01-19 Boston Scientific Corporation Multiple hole drug delivery balloon
US5865723A (en) * 1995-12-29 1999-02-02 Ramus Medical Technologies Method and apparatus for forming vascular prostheses
US5865814A (en) * 1995-06-07 1999-02-02 Medtronic, Inc. Blood contacting medical device and method
US5866113A (en) * 1996-05-31 1999-02-02 Medtronic, Inc. Medical device with biomolecule-coated surface graft matrix
US6010445A (en) * 1997-09-11 2000-01-04 Implant Sciences Corporation Radioactive medical device and process
US6010530A (en) * 1995-06-07 2000-01-04 Boston Scientific Technology, Inc. Self-expanding endoluminal prosthesis
US6010573A (en) * 1998-07-01 2000-01-04 Virginia Commonwealth University Apparatus and method for endothelial cell seeding/transfection of intravascular stents
US6011125A (en) * 1998-09-25 2000-01-04 General Electric Company Amide modified polyesters
US6013099A (en) * 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
US6168619B1 (en) * 1998-10-16 2001-01-02 Quanam Medical Corporation Intravascular stent having a coaxial polymer member and end sleeves
US6168617B1 (en) * 1999-06-14 2001-01-02 Scimed Life Systems, Inc. Stent delivery system
US6171609B1 (en) * 1995-02-15 2001-01-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6172167B1 (en) * 1996-06-28 2001-01-09 Universiteit Twente Copoly(ester-amides) and copoly(ester-urethanes)
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6174316B1 (en) * 1998-05-28 2001-01-16 Medtronic, Inc. Stent delivery system
US6177523B1 (en) * 1999-07-14 2001-01-23 Cardiotech International, Inc. Functionalized polyurethanes
US6180632B1 (en) * 1997-05-28 2001-01-30 Aventis Pharmaceuticals Products Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6335029B1 (en) * 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US20020004101A1 (en) * 1995-04-19 2002-01-10 Schneider (Usa) Inc. Drug coating with topcoat
US6503954B1 (en) * 2000-03-31 2003-01-07 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing actinomycin D and a method of forming the same
US6503538B1 (en) * 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
US6504307B1 (en) * 2000-11-30 2003-01-07 Advanced Cardiovascular Systems, Inc. Application of variable bias voltage on a cylindrical grid enclosing a target
US6503556B2 (en) * 2000-12-28 2003-01-07 Advanced Cardiovascular Systems, Inc. Methods of forming a coating for a prosthesis
US6506437B1 (en) * 2000-10-17 2003-01-14 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device having depots formed in a surface thereof
US6510722B1 (en) * 2000-05-10 2003-01-28 Advanced Cardiovascular Systems, Inc. Stent crimping tool for producing a grooved crimp
US6511748B1 (en) * 1998-01-06 2003-01-28 Aderans Research Institute, Inc. Bioabsorbable fibers and reinforced composites produced therefrom
US6673154B1 (en) * 2001-06-28 2004-01-06 Advanced Cardiovascular Systems, Inc. Stent mounting device to coat a stent
US6673385B1 (en) * 2000-05-31 2004-01-06 Advanced Cardiovascular Systems, Inc. Methods for polymeric coatings stents
US6676700B1 (en) * 1999-10-13 2004-01-13 Advanced Cardiovascular Systems, Inc. Stent with radiopaque core
US6676697B1 (en) * 1996-09-19 2004-01-13 Medinol Ltd. Stent with variable features to optimize support and method of making such stent
US6679980B1 (en) * 2001-06-13 2004-01-20 Advanced Cardiovascular Systems, Inc. Apparatus for electropolishing a stent
US6846323B2 (en) * 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent
US20060014720A1 (en) * 2004-06-18 2006-01-19 Advanced Cardiovascular Systems, Inc. Heparin prodrugs and drug delivery stents formed therefrom

Family Cites Families (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR732895A (en) 1932-10-18 1932-09-25 Consortium Elektrochem Ind Objects spun polyvinyl alcohol
US2386454A (en) 1940-11-22 1945-10-09 Bell Telephone Labor Inc High molecular weight linear polyester-amides
US2647017A (en) 1951-04-19 1953-07-28 Ind Res Inst Nozzle
US3288728A (en) 1966-02-18 1966-11-29 Union Carbide Corp Para-xylylene copolymers
US3849514A (en) 1967-11-17 1974-11-19 Eastman Kodak Co Block polyester-polyamide copolymers
GB1237035A (en) 1969-08-20 1971-06-30 Tsi Travmatologii I Ortopedii Magnesium-base alloy for use in bone surgery
US3900632A (en) 1970-02-27 1975-08-19 Kimberly Clark Co Laminate of tissue and random laid continuous filament web
US3773737A (en) 1971-06-09 1973-11-20 Sutures Inc Hydrolyzable polymers of amino acid and hydroxy acids
US3839743A (en) 1972-04-21 1974-10-08 A Schwarcz Method for maintaining the normal integrity of blood
US3753615A (en) 1972-04-26 1973-08-21 Dyk Res Corp Van Scanning apparatus
US4104410A (en) 1973-12-21 1978-08-01 Malecki George J Processing of green vegetables for color retention in canning
US4164524A (en) * 1974-05-31 1979-08-14 Ward Charles A Treatment of blood containing vessels
US4110497A (en) 1976-07-02 1978-08-29 Snyder Manufacturing Co., Ltd. Striped laminate and method and apparatus for making same
JPS5418317A (en) 1977-07-11 1979-02-10 Ricoh Kk Tape feeder
US4323071B1 (en) 1978-04-24 1990-05-29 Advanced Cardiovascular System
JPS6037735B2 (en) 1978-10-18 1985-08-28 Sumitomo Electric Industries
GB2041377B (en) * 1979-01-22 1983-09-28 Woodroof Lab Inc Bio compatible and blood compatible materials and methods
DE2928007A1 (en) 1979-07-11 1981-01-15 Riess Guido Dr Bone implantatkoerper for prostheses and knochenverbindungsstuecke and process for its manufacture
US4329383A (en) 1979-07-24 1982-05-11 Nippon Zeon Co., Ltd. Non-thrombogenic material comprising substrate which has been reacted with heparin
US4226243A (en) 1979-07-27 1980-10-07 Ethicon, Inc. Surgical devices of polyesteramides derived from bis-oxamidodiols and dicarboxylic acids
US4346028A (en) 1979-12-14 1982-08-24 Monsanto Company Asbestiform crystalline calcium sodium or lithium phosphate, preparation and compositions
US4343931A (en) 1979-12-17 1982-08-10 Minnesota Mining And Manufacturing Company Synthetic absorbable surgical devices of poly(esteramides)
US4529792A (en) 1979-12-17 1985-07-16 Minnesota Mining And Manufacturing Company Process for preparing synthetic absorbable poly(esteramides)
US4629563B1 (en) 1980-03-14 1997-06-03 Memtec North America Asymmetric membranes
US4774039A (en) 1980-03-14 1988-09-27 Brunswick Corporation Dispersing casting of integral skinned highly asymmetric polymer membranes
DE3019996C2 (en) 1980-05-24 1990-02-08 Deutsche Institute Fuer Textil- Und Faserforschung Stuttgart - Stiftung Des Oeffentlichen Rechts, 7306 Denkendorf, De
US4608984A (en) 1980-10-17 1986-09-02 Fogarty Thomas J Self-retracting dilatation catheter
US4338942A (en) 1980-10-20 1982-07-13 Fogarty Thomas J Dilatation catherter apparatus
US4439185A (en) 1981-10-21 1984-03-27 Advanced Cardiovascular Systems, Inc. Inflating and deflating device for vascular dilating catheter assembly
US4880683A (en) 1981-12-28 1989-11-14 Minnesota Mining And Manufacturing Company Hot-tackifying adhesive tape
US4516972A (en) 1982-01-28 1985-05-14 Advanced Cardiovascular Systems, Inc. Guiding catheter and method of manufacture
US5619212A (en) 1982-03-01 1997-04-08 Western Atlas International, Inc. System for determining position from suppressed carrier radio waves
US4894662A (en) 1982-03-01 1990-01-16 Western Atlas International, Inc. Method and system for determining position on a moving platform, such as a ship, using signals from GPS satellites
US4489670A (en) 1983-05-16 1984-12-25 Sermetel Fixture for centrifugal apparatus
FR2547704B1 (en) 1983-06-24 1985-11-29 Morin Claude perfects Helmet
US4554929A (en) 1983-07-13 1985-11-26 Advanced Cardiovascular Systems, Inc. Catheter guide wire with short spring tip and method of using the same
US4656083A (en) 1983-08-01 1987-04-07 Washington Research Foundation Plasma gas discharge treatment for improving the biocompatibility of biomaterials
US4702252A (en) 1983-10-13 1987-10-27 Smiths Industries Public Limited Company Catheters
US4616652A (en) 1983-10-19 1986-10-14 Advanced Cardiovascular Systems, Inc. Dilatation catheter positioning apparatus
US4538622A (en) 1983-11-10 1985-09-03 Advanced Cardiovascular Systems, Inc. Guide wire for catheters
US5669936A (en) 1983-12-09 1997-09-23 Endovascular Technologies, Inc. Endovascular grafting system and method for use therewith
US5197977A (en) 1984-01-30 1993-03-30 Meadox Medicals, Inc. Drug delivery collagen-impregnated synthetic vascular graft
US4596574A (en) 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4573470A (en) 1984-05-30 1986-03-04 Advanced Cardiovascular Systems, Inc. Low-profile steerable intraoperative balloon dilitation catheter
US4612009A (en) 1984-06-19 1986-09-16 Ceskoslovenska Akademie Ved Biodegradable implant and a method for preparation thereof
US4879135A (en) 1984-07-23 1989-11-07 University Of Medicine And Dentistry Of New Jersey Drug bonded prosthesis and process for producing same
US4965586A (en) 1984-08-16 1990-10-23 Geostar Corporation Position determination and message transfer system employing satellites and stored terrain map
JPH0334380B2 (en) 1984-09-19 1991-05-22 Yoshida Kogyo Kk
ES549567A0 (en) 1984-12-05 1987-05-01 Medinvent Sa A device for implanting, by insertion into a hard Lugarde access, a substantially tubular radially expandable prothesis and
US4699611A (en) 1985-04-19 1987-10-13 C. R. Bard, Inc. Biliary stent introducer
US5628781A (en) 1985-06-06 1997-05-13 Thomas Jefferson University Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated implants themselves
US4656242A (en) 1985-06-07 1987-04-07 Henkel Corporation Poly(ester-amide) compositions
US4818559A (en) 1985-08-08 1989-04-04 Sumitomo Chemical Company, Limited Method for producing endosseous implants
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4807256A (en) 1985-12-23 1989-02-21 Texas Instruments Incorporated Global position system receiver
US4611051A (en) 1985-12-31 1986-09-09 Union Camp Corporation Novel poly(ester-amide) hot-melt adhesives
US4743252A (en) 1986-01-13 1988-05-10 Corvita Corporation Composite grafts
EP0556940A1 (en) 1986-02-24 1993-08-25 Robert E. Fischell Intravascular stent
US4878906A (en) 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
DE3778195D1 (en) 1986-04-07 1992-05-21 Agency Ind Science Techn Antithrombogenisches material.
US4882168A (en) 1986-09-05 1989-11-21 American Cyanamid Company Polyesters containing alkylene oxide blocks as drug delivery systems
US4740207A (en) 1986-09-10 1988-04-26 Kreamer Jeffry W Intralumenal graft
US4890233A (en) 1986-10-27 1989-12-26 Pioneer Electronic Corporation Vehicle bearing detection and data processing methods applicable to vehicle navigation system
JPH0696023B2 (en) 1986-11-10 1994-11-30 宇部日東化成株式会社 Artificial blood vessel and a method of manufacturing the same
US5370684A (en) 1986-12-12 1994-12-06 Sorin Biomedica S.P.A. Prosthesis of polymeric material coated with biocompatible carbon
US4748982A (en) 1987-01-06 1988-06-07 Advanced Cardiovascular Systems, Inc. Reinforced balloon dilatation catheter with slitted exchange sleeve and method
WO1988006026A3 (en) 1987-02-17 1988-10-06 Alberto Arpesani Internal prosthesis for the substitution of a part of the human body particularly in vascular surgery
JPH0351430B2 (en) 1987-03-25 1991-08-06 Terumo Corp
US4816339A (en) 1987-04-28 1989-03-28 Baxter International Inc. Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation
US4871542A (en) 1987-04-30 1989-10-03 Ferring Service Center, N.V. Method and apparatus useful for delivering medicinal compositions into the bladder and urinary tract
US5059211A (en) 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
WO1989003197A1 (en) 1987-10-08 1989-04-20 Terumo Kabushiki Kaisha Instrument and apparatus for securing inner diameter of lumen of tubular organ
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US4906423A (en) 1987-10-23 1990-03-06 Dow Corning Wright Methods for forming porous-surfaced polymeric bodies
US4932353A (en) 1987-12-18 1990-06-12 Mitsubishi Denki Kabushiki Kaisha Chemical coating apparatus
US4877030A (en) 1988-02-02 1989-10-31 Andreas Beck Device for the widening of blood vessels
US5019096A (en) 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US5192311A (en) 1988-04-25 1993-03-09 Angeion Corporation Medical implant and method of making
US5109344A (en) 1988-04-28 1992-04-28 Mazda Motor Corporation Vehicle navigation apparatus employing node selection, comparison and elimination techniques
US4967606A (en) 1988-04-29 1990-11-06 Caveo Scientific Instruments, Inc. Method and apparatus for pipetting liquids
US4931287A (en) 1988-06-14 1990-06-05 University Of Utah Heterogeneous interpenetrating polymer networks for the controlled release of drugs
US4865870A (en) * 1988-07-07 1989-09-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic
DE68920925D1 (en) 1988-07-11 1995-03-16 Terumo Corp Medical materials and device.
DE68922497D1 (en) 1988-08-24 1995-06-08 Marvin J Slepian Endoluminal seal with bisdegradierbaren polymeric.
US5226913A (en) 1988-09-01 1993-07-13 Corvita Corporation Method of making a radially expandable prosthesis
US5019090A (en) 1988-09-01 1991-05-28 Corvita Corporation Radially expandable endoprosthesis and the like
US5053048A (en) 1988-09-22 1991-10-01 Cordis Corporation Thromboresistant coating
US4943346A (en) 1988-09-29 1990-07-24 Siemens Aktiengesellschaft Method for manufacturing printed circuit boards
US4950227A (en) 1988-11-07 1990-08-21 Boston Scientific Corporation Stent delivery system
US4977901A (en) 1988-11-23 1990-12-18 Minnesota Mining And Manufacturing Company Article having non-crosslinked crystallized polymer coatings
CA2008312C (en) 1989-01-26 2000-05-30 Ulrich Sigwart Intravascular endoprothesis
US5289831A (en) 1989-03-09 1994-03-01 Vance Products Incorporated Surface-treated stent, catheter, cannula, and the like
US5062829A (en) 1989-03-17 1991-11-05 Carter Holt Harvey Plastic Products Group Limited Relates to devices for administering a substance such as a drug or chemical or the like
US5146471A (en) 1989-03-23 1992-09-08 Echelon Systems Corporation Correlator for spread spectrum communications systems
US5108755A (en) 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US4955899A (en) 1989-05-26 1990-09-11 Impra, Inc. Longitudinally compliant vascular graft
US5040548A (en) 1989-06-01 1991-08-20 Yock Paul G Angioplasty mehtod
US5037392A (en) 1989-06-06 1991-08-06 Cordis Corporation Stent-implanting balloon assembly
US5059169A (en) 1989-07-07 1991-10-22 C. R. Bard, Inc. High-friction prostatic stent
US5455040A (en) * 1990-07-26 1995-10-03 Case Western Reserve University Anticoagulant plasma polymer-modified substrate
US5015505A (en) 1989-09-25 1991-05-14 Bridgestone/Firestone, Inc. Method and apparatus for striping a tire sidewall
US5035706A (en) 1989-10-17 1991-07-30 Cook Incorporated Percutaneous stent and method for retrieval thereof
US5610815A (en) 1989-12-11 1997-03-11 Caterpillar Inc. Integrated vehicle positioning and navigation system, apparatus and method
US5059166A (en) 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5049132A (en) 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
DE69108423T2 (en) 1990-02-08 1995-07-27 Howmedica Inflatable dilator.
NL194941C (en) * 1990-02-15 2003-08-04 Cordis Corp A method for the application of a physiologically active substance on a substrate surface.
US5545208A (en) * 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5156623A (en) 1990-04-16 1992-10-20 Olympus Optical Co., Ltd. Sustained release material and method of manufacturing the same
US5290271A (en) 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
EP0737453A3 (en) 1990-05-18 1997-02-05 Richard S Stack Intraluminal stent
US5360443A (en) 1990-06-11 1994-11-01 Barone Hector D Aortic graft for repairing an abdominal aortic aneurysm
GB9013527D0 (en) 1990-06-18 1990-08-08 Philips Electronic Associated Method of and apparatus for obtaining vehicle heading information
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5236447A (en) 1990-06-29 1993-08-17 Nissho Corporation Artificial tubular organ
US5222971A (en) 1990-10-09 1993-06-29 Scimed Life Systems, Inc. Temporary stent and methods for use and manufacture
EP0506918B1 (en) 1990-10-18 1996-01-03 SONG, Ho Young Self-expanding endovascular stent
JP2657581B2 (en) 1990-11-28 1997-09-24 本田技研工業株式会社 Current position display device of a moving body
US5390207A (en) 1990-11-28 1995-02-14 Novatel Communications Ltd. Pseudorandom noise ranging receiver which compensates for multipath distortion by dynamically adjusting the time delay spacing between early and late correlators
US5116365A (en) 1991-02-22 1992-05-26 Cordis Corporation Stent apparatus and method for making
US5347284A (en) 1991-02-28 1994-09-13 Texas Instruments Incorporated System and method for a digital navigation satellite receiver
JP2939893B2 (en) 1991-04-24 1999-08-25 バクスター インターナショナル インコーポレーテッド Replaceable integral - wire balloon catheter
US5225842A (en) 1991-05-09 1993-07-06 Navsys Corporation Vehicle tracking system employing global positioning system (gps) satellites
DE69219006D1 (en) 1991-05-21 1997-05-22 Matsushita Electric Ind Co Ltd Vehicle positioning device
US5304200A (en) 1991-05-29 1994-04-19 Cordis Corporation Welded radially expandable endoprosthesis and the like
US5234416A (en) 1991-06-06 1993-08-10 Advanced Cardiovascular Systems, Inc. Intravascular catheter with a nontraumatic distal tip
JPH04369492A (en) 1991-06-18 1992-12-22 Pioneer Electron Corp Gps position measurement device
US5356433A (en) 1991-08-13 1994-10-18 Cordis Corporation Biocompatible metal surfaces
US5269802A (en) 1991-09-10 1993-12-14 Garber Bruce B Prostatic stent
US5314472A (en) 1991-10-01 1994-05-24 Cook Incorporated Vascular stent
WO1993006792A1 (en) 1991-10-04 1993-04-15 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5234457A (en) 1991-10-09 1993-08-10 Boston Scientific Corporation Impregnated stent
CA2079417C (en) 1991-10-28 2003-01-07 Lilip Lau Expandable stents and method of making same
US5493588A (en) 1992-01-22 1996-02-20 Trimble Navigation Limited Multipath compensation for code phase signals
US5571166A (en) 1992-03-19 1996-11-05 Medtronic, Inc. Method of making an intraluminal stent
DE69318614T2 (en) 1992-03-25 1998-11-05 Cook Inc Means for widening of blood vessels
US5323152A (en) 1992-04-15 1994-06-21 Sumitomo Electric Industries, Ltd. Apparatus for detecting the position of a vehicle
DE4222380A1 (en) 1992-07-08 1994-01-13 Ernst Peter Prof Dr M Strecker In the body of a patient percutaneously implantable endoprosthesis
JPH0638851A (en) 1992-07-21 1994-02-15 Itoki Crebio Corp Seat
JP3295454B2 (en) 1992-08-05 2002-06-24 パイオニア株式会社 Signal processing method of Gps receiver
US5342621A (en) 1992-09-15 1994-08-30 Advanced Cardiovascular Systems, Inc. Antithrombogenic surface
US5390124A (en) 1992-12-01 1995-02-14 Caterpillar Inc. Method and apparatus for improving the accuracy of position estimates in a satellite based navigation system
US5342348A (en) 1992-12-04 1994-08-30 Kaplan Aaron V Method and device for treating and enlarging body lumens
US5336518A (en) * 1992-12-11 1994-08-09 Cordis Corporation Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents
EP0604022A1 (en) 1992-12-22 1994-06-29 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method for its manufacture
US5423849A (en) 1993-01-15 1995-06-13 Target Therapeutics, Inc. Vasoocclusion device containing radiopaque fibers
US5347536A (en) 1993-03-17 1994-09-13 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Multipath noise reduction for spread spectrum signals
US5441515A (en) 1993-04-23 1995-08-15 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US5824048A (en) * 1993-04-26 1998-10-20 Medtronic, Inc. Method for delivering a therapeutic substance to a body lumen
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5471218A (en) 1993-07-01 1995-11-28 Trimble Navigation Limited Integrated terrestrial survey and satellite positioning system
US5618298A (en) 1993-10-23 1997-04-08 Simon; Michael Vascular prosthesis made of resorbable material
DE4336705C2 (en) 1993-10-27 1996-11-28 Hoffmann Elektrokohle Sliding contact element and method for connecting an electrical terminal conductor having a sliding contact element
US5493694A (en) 1993-11-08 1996-02-20 Trimble Navigation Limited Fast response system for a fleet of vehicles
JP2661534B2 (en) 1993-12-28 1997-10-08 日本電気株式会社 Spread spectrum reception method and receiver
US5588962A (en) * 1994-03-29 1996-12-31 Boston Scientific Corporation Drug treatment of diseased sites deep within the body
US5485163A (en) 1994-03-30 1996-01-16 Motorola, Inc. Personal locator system
US5479351A (en) 1994-04-22 1995-12-26 Trimble Navigation Limited Time-keeping system and method for synchronizing independent recordings of a live performance in post-recording editing
US5504491A (en) 1994-04-25 1996-04-02 Chapman; Robert W. Global status and position reporting system
US5495257A (en) 1994-07-19 1996-02-27 Trimble Navigation Limited Inverse differential corrections for SATPS mobile stations
US5541845A (en) 1994-08-02 1996-07-30 Trimble Navigation Limited Monitoring of route and schedule adherence
US5486834A (en) 1994-08-08 1996-01-23 Trimble Navigation Limited Global orbiting navigation satellite system receiver
US5490076A (en) 1994-09-12 1996-02-06 Itt Corporation Apparatus and method for autonavigation with one or more orbiting satellites and an anchor station
US5485161A (en) 1994-11-21 1996-01-16 Trimble Navigation Limited Vehicle speed control based on GPS/MAP matching of posted speeds
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5628755A (en) 1995-02-20 1997-05-13 Schneider (Europe) A.G. Balloon catheter and stent delivery system
DE69518337D1 (en) 1995-03-10 2000-09-14 Impra Inc Endoluminal stent encapsulated and manufacturing
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US5537121A (en) 1995-04-28 1996-07-16 Trimble Navigation Limited Carrier phase multipath reduction technique
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
CA2179083A1 (en) 1995-08-01 1997-02-02 Michael S. Williams Composite metal and polymer locking stents for drug delivery
US5804318A (en) * 1995-10-26 1998-09-08 Corvita Corporation Lubricious hydrogel surface modification
US6120535A (en) * 1996-07-29 2000-09-19 Radiance Medical Systems, Inc. Microporous tubular prosthesis
JP3938418B2 (en) 1996-09-25 2007-06-27 テルモ株式会社 Stent
US6174326B1 (en) 1996-09-25 2001-01-16 Terumo Kabushiki Kaisha Radiopaque, antithrombogenic stent and method for its production
US5997517A (en) * 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
US6776792B1 (en) * 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
DE19731021A1 (en) * 1997-07-18 1999-01-21 Meyer Joerg In vivo degradable metallic implant
US6613432B2 (en) * 1999-12-22 2003-09-02 Biosurface Engineering Technologies, Inc. Plasma-deposited coatings, devices and methods
US6981987B2 (en) * 1999-12-22 2006-01-03 Ethicon, Inc. Removable stent for body lumens
US20020007214A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020007213A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020007215A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020005206A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Antiproliferative drug and delivery device
US6395326B1 (en) * 2000-05-31 2002-05-28 Advanced Cardiovascular Systems, Inc. Apparatus and method for depositing a coating onto a surface of a prosthesis
WO2002072014A3 (en) * 2001-03-08 2003-04-24 David L Brown Medical devices, compositions and methods for treating vulnerable plaque
US6682771B2 (en) * 2001-07-02 2004-01-27 Scimed Life Systems, Inc. Coating dispensing system and method using a solenoid head for coating medical devices

Patent Citations (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180632B2 (en) *
US2701559A (en) * 1951-08-02 1955-02-08 William A Cooper Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US4075045A (en) * 1976-02-09 1978-02-21 International Business Machines Corporation Method for fabricating FET one-device memory cells with two layers of polycrystalline silicon and fabrication of integrated circuits containing arrays of the memory cells charge storage capacitors utilizing five basic pattern deliberating steps
US4132357A (en) * 1976-06-23 1979-01-02 Inmont Corporation Apparatus and method for spray application of solvent-thinned coating compositions
US4902289A (en) * 1982-04-19 1990-02-20 Massachusetts Institute Of Technology Multilayer bioreplaceable blood vessel prosthesis
US4633873A (en) * 1984-04-26 1987-01-06 American Cyanamid Company Surgical repair mesh
US4718907A (en) * 1985-06-20 1988-01-12 Atrium Medical Corporation Vascular prosthesis having fluorinated coating with varying F/C ratio
US4638805A (en) * 1985-07-30 1987-01-27 Advanced Cardiovascular Systems, Inc. Self-venting balloon dilatation catheter and method
US4723549A (en) * 1986-09-18 1988-02-09 Wholey Mark H Method and apparatus for dilating blood vessels
US4722335A (en) * 1986-10-20 1988-02-02 Vilasi Joseph A Expandable endotracheal tube
US4988356A (en) * 1987-02-27 1991-01-29 C. R. Bard, Inc. Catheter and guidewire exchange system
US5721131A (en) * 1987-03-06 1998-02-24 United States Of America As Represented By The Secretary Of The Navy Surface modification of polymers with self-assembled monolayers that promote adhesion, outgrowth and differentiation of biological cells
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
US5081394A (en) * 1987-09-01 1992-01-14 Hitachi, Ltd. Black matrix color picture tube
US4994298A (en) * 1988-06-07 1991-02-19 Biogold Inc. Method of making a biocompatible prosthesis
US5085629A (en) * 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US5087244A (en) * 1989-01-31 1992-02-11 C. R. Bard, Inc. Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen
US5387450A (en) * 1989-05-11 1995-02-07 Landec Corporation Temperature-activated adhesive assemblies
US4994033A (en) * 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5084065A (en) * 1989-07-10 1992-01-28 Corvita Corporation Reinforced graft assembly
US5087394A (en) * 1989-11-09 1992-02-11 Scimed Life Systems, Inc. Method for forming an inflatable balloon for use in a catheter
US5176638A (en) * 1990-01-12 1993-01-05 Don Michael T Anthony Regional perfusion catheter with improved drug delivery control
US5078720A (en) * 1990-05-02 1992-01-07 American Medical Systems, Inc. Stent placement instrument and method
US5279594A (en) * 1990-05-23 1994-01-18 Jackson Richard R Intubation devices with local anesthetic effect for medical use
US5286254A (en) * 1990-06-15 1994-02-15 Cortrak Medical, Inc. Drug delivery apparatus and method
US5385580A (en) * 1990-08-28 1995-01-31 Meadox Medicals, Inc. Self-supporting woven vascular graft
US5711763A (en) * 1991-02-20 1998-01-27 Tdk Corporation Composite biological implant of a ceramic material in a metal substrate
US5188734A (en) * 1991-03-26 1993-02-23 Memtec America Corporation Ultraporous and microporous integral membranes
US5282860A (en) * 1991-10-16 1994-02-01 Olympus Optical Co., Ltd. Stent tube for medical use
US5593434A (en) * 1992-01-31 1997-01-14 Advanced Cardiovascular Systems, Inc. Stent capable of attachment within a body lumen
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US5599352A (en) * 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
US5591224A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Bioelastomeric stent
US5282823A (en) * 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5591227A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Drug eluting stent
US5858746A (en) * 1992-04-20 1999-01-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5383927A (en) * 1992-05-07 1995-01-24 Intervascular Inc. Non-thromogenic vascular prosthesis
US5383925A (en) * 1992-09-14 1995-01-24 Meadox Medicals, Inc. Three-dimensional braided soft tissue prosthesis
US5278200A (en) * 1992-10-30 1994-01-11 Medtronic, Inc. Thromboresistant material and articles
US5720726A (en) * 1992-12-30 1998-02-24 Medtronic, Inc. Balloon catheter having retention enhancements on the balloon
US5275012A (en) * 1993-01-07 1994-01-04 Ford Motor Company Climate control system for electric vehicle
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US5716981A (en) * 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5599307A (en) * 1993-07-26 1997-02-04 Loyola University Of Chicago Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities
US5380299A (en) * 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
US5855598A (en) * 1993-10-21 1999-01-05 Corvita Corporation Expandable supportive branched endoluminal grafts
US5389106A (en) * 1993-10-29 1995-02-14 Numed, Inc. Impermeable expandable intravascular stent
US5599301A (en) * 1993-11-22 1997-02-04 Advanced Cardiovascular Systems, Inc. Motor control system for an automatic catheter inflation system
US5591607A (en) * 1994-03-18 1997-01-07 Lynx Therapeutics, Inc. Oligonucleotide N3→P5' phosphoramidates: triplex DNA formation
US6169170B1 (en) * 1994-03-18 2001-01-02 Lynx Therapeutics, Inc. Oligonucleotide N3′→N5′Phosphoramidate Duplexes
US5599922A (en) * 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
US5857998A (en) * 1994-06-30 1999-01-12 Boston Scientific Corporation Stent and therapeutic delivery system
US5593403A (en) * 1994-09-14 1997-01-14 Scimed Life Systems Inc. Method for modifying a stent in an implanted site
US5485496A (en) * 1994-09-22 1996-01-16 Cornell Research Foundation, Inc. Gamma irradiation sterilizing of biomaterial medical devices or products, with improved degradation and mechanical properties
US5707385A (en) * 1994-11-16 1998-01-13 Advanced Cardiovascular Systems, Inc. Drug loaded elastic membrane and method for delivery
US6171609B1 (en) * 1995-02-15 2001-01-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5605696A (en) * 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US5860954A (en) * 1995-03-31 1999-01-19 Boston Scientific Corporation Multiple hole drug delivery balloon
US20020004101A1 (en) * 1995-04-19 2002-01-10 Schneider (Usa) Inc. Drug coating with topcoat
US5855612A (en) * 1995-05-12 1999-01-05 Ohta Inc. Biocompatible titanium implant
US5711812A (en) * 1995-06-06 1998-01-27 Varian Associates, Inc. Apparatus for obtaining dose uniformity in plasma doping (PLAD) ion implantation processes
US5591199A (en) * 1995-06-07 1997-01-07 Porter; Christopher H. Curable fiber composite stent and delivery system
US6010530A (en) * 1995-06-07 2000-01-04 Boston Scientific Technology, Inc. Self-expanding endoluminal prosthesis
US5865814A (en) * 1995-06-07 1999-02-02 Medtronic, Inc. Blood contacting medical device and method
US5718726A (en) * 1995-09-12 1998-02-17 Biotronik Mess- und Therapiegerate GmbH & Co Method of attaching heparin to, and immobilizing it on, inorganic substrate surfaces of cardiovascular implants
US5865723A (en) * 1995-12-29 1999-02-02 Ramus Medical Technologies Method and apparatus for forming vascular prostheses
US5866113A (en) * 1996-05-31 1999-02-02 Medtronic, Inc. Medical device with biomolecule-coated surface graft matrix
US6172167B1 (en) * 1996-06-28 2001-01-09 Universiteit Twente Copoly(ester-amides) and copoly(ester-urethanes)
US5711958A (en) * 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5713949A (en) * 1996-08-06 1998-02-03 Jayaraman; Swaminathan Microporous covered stents and method of coating
US5855618A (en) * 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
US6676697B1 (en) * 1996-09-19 2004-01-13 Medinol Ltd. Stent with variable features to optimize support and method of making such stent
US5858556A (en) * 1997-01-21 1999-01-12 Uti Corporation Multilayer composite tubular structure and method of making
US5858990A (en) * 1997-03-04 1999-01-12 St. Elizabeth's Medical Center Fas ligand compositions for treatment of proliferative disorders
US6180632B1 (en) * 1997-05-28 2001-01-30 Aventis Pharmaceuticals Products Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6010445A (en) * 1997-09-11 2000-01-04 Implant Sciences Corporation Radioactive medical device and process
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
US6511748B1 (en) * 1998-01-06 2003-01-28 Aderans Research Institute, Inc. Bioabsorbable fibers and reinforced composites produced therefrom
US6013099A (en) * 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US6174316B1 (en) * 1998-05-28 2001-01-16 Medtronic, Inc. Stent delivery system
US6010573A (en) * 1998-07-01 2000-01-04 Virginia Commonwealth University Apparatus and method for endothelial cell seeding/transfection of intravascular stents
US6335029B1 (en) * 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US6011125A (en) * 1998-09-25 2000-01-04 General Electric Company Amide modified polyesters
US6168619B1 (en) * 1998-10-16 2001-01-02 Quanam Medical Corporation Intravascular stent having a coaxial polymer member and end sleeves
US6168617B1 (en) * 1999-06-14 2001-01-02 Scimed Life Systems, Inc. Stent delivery system
US6177523B1 (en) * 1999-07-14 2001-01-23 Cardiotech International, Inc. Functionalized polyurethanes
US6676700B1 (en) * 1999-10-13 2004-01-13 Advanced Cardiovascular Systems, Inc. Stent with radiopaque core
US6503954B1 (en) * 2000-03-31 2003-01-07 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing actinomycin D and a method of forming the same
US6510722B1 (en) * 2000-05-10 2003-01-28 Advanced Cardiovascular Systems, Inc. Stent crimping tool for producing a grooved crimp
US6673385B1 (en) * 2000-05-31 2004-01-06 Advanced Cardiovascular Systems, Inc. Methods for polymeric coatings stents
US6503538B1 (en) * 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
US6506437B1 (en) * 2000-10-17 2003-01-14 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device having depots formed in a surface thereof
US6504307B1 (en) * 2000-11-30 2003-01-07 Advanced Cardiovascular Systems, Inc. Application of variable bias voltage on a cylindrical grid enclosing a target
US6503556B2 (en) * 2000-12-28 2003-01-07 Advanced Cardiovascular Systems, Inc. Methods of forming a coating for a prosthesis
US6679980B1 (en) * 2001-06-13 2004-01-20 Advanced Cardiovascular Systems, Inc. Apparatus for electropolishing a stent
US6673154B1 (en) * 2001-06-28 2004-01-06 Advanced Cardiovascular Systems, Inc. Stent mounting device to coat a stent
US6846323B2 (en) * 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent
US20060014720A1 (en) * 2004-06-18 2006-01-19 Advanced Cardiovascular Systems, Inc. Heparin prodrugs and drug delivery stents formed therefrom

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100173065A1 (en) * 2001-07-30 2010-07-08 Advanced Cardiovascular Systems, Inc. Methods For Immobilizing Anti-Thrombogenic Material Onto A Medical Device Or Into A Coating Thereon
US8263170B2 (en) 2001-07-30 2012-09-11 Advanced Cardiovascular Systems, Inc. Methods for immobilizing anti-thrombogenic material onto a medical device or into a coating thereon
US20090299463A1 (en) * 2001-11-30 2009-12-03 Advanced Cardiovascular Systems, Inc. Modified Surface For An Implantable Device And A Method Of Producing The Same
US8123799B1 (en) 2001-11-30 2012-02-28 Advanced Cardiovascular Systems, Inc. Modified implantable device surface and a method of making the same
US8382815B2 (en) 2001-11-30 2013-02-26 Advanced Cardiovascular Systems, Inc. TiNxCy modified surface for an implantable device and a method of producing the same
US8470019B1 (en) 2001-11-30 2013-06-25 Advanced Cardiovascular Systems, Inc. TiNxOy modified surface for an implantable device and a method of producing the same
US8834555B2 (en) 2001-11-30 2014-09-16 Abbott Cardiovascular Systems Inc. TiNxCy modified surface for an implantable device and a method of producing the same
US8864818B2 (en) 2001-11-30 2014-10-21 Abbott Cardiovascular Systems Inc. TiNxOy Modified surface for an implantable device and a method of producing the same
US9561309B2 (en) 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings

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EP0873732A1 (en) 1998-10-28 application
JPH10309320A (en) 1998-11-24 application
JP3000076B2 (en) 2000-01-17 grant
EP0873732B1 (en) 2001-08-29 grant
US6605114B1 (en) 2003-08-12 grant
DE69801459T2 (en) 2002-04-11 grant
US7077860B2 (en) 2006-07-18 grant
US20040236417A1 (en) 2004-11-25 application
DE69801459D1 (en) 2001-10-04 grant
US6776792B1 (en) 2004-08-17 grant

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