US20060110607A1 - Aluminum oxide ceramics with hydroxyapatite - Google Patents
Aluminum oxide ceramics with hydroxyapatite Download PDFInfo
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- US20060110607A1 US20060110607A1 US11/252,377 US25237705A US2006110607A1 US 20060110607 A1 US20060110607 A1 US 20060110607A1 US 25237705 A US25237705 A US 25237705A US 2006110607 A1 US2006110607 A1 US 2006110607A1
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- coating
- hydroxyapatite
- titanium
- ceramic component
- ceramic
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
- C04B41/009—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone characterised by the material treated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
- A61L27/105—Ceramics or glasses containing Al2O3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
- C04B41/45—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements
- C04B41/52—Multiple coating or impregnating multiple coating or impregnating with the same composition or with compositions only differing in the concentration of the constituents, is classified as single coating or impregnation
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
- C04B41/80—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone of only ceramics
- C04B41/81—Coating or impregnation
- C04B41/89—Coating or impregnation for obtaining at least two superposed coatings having different compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/12—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by mechanical means
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
- C23C14/06—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
- C23C14/14—Metallic material, boron or silicon
Definitions
- the subject of the present invention is a method for the manufacture of ceramic components coated with hydroxyapatite, as well as the ceramic components which can be manufactured by this method.
- the spray parameters was also modified in the plasma coating apparatus. But even the modified process parameters did not lead to success.
- the cause of the poor strength of adhesion was determined to be the differences in roughness between the metal and the ceramic. A surface roughness of R a ⁇ 30 ⁇ m cannot be achieved by conventional abrasive methods.
- FIG. 3 shows the typical surface after the laser treatment.
- the lasered surface of the aluminum oxide ceramic was then subjected to plasma coating with hydroxyapatite. For the first time a few placed on this surface were detected, on which the hydroxyapatite coating could be detected. Of course, it was not possible even by this preliminary treatment to apply a continuous coating.
- FIGS. 4 and 5 show the surfaces of the lasered and hydroxyapatite (HA) coated specimens.
- the present invention is addressed to the problem of making available a method by which ceramic components can reliably be provided with a hydroxyapatite coating.
- FIG. 1 is an SEM showing a typical surface after laser treatment.
- FIG. 2 and 3 are SEMs showing the surfaces of the lasered and hydroxyapatite coated specimens.
- FIGS. 4 and 5 are SEMs showing the transverse section of a lasered end and hydroxyapatite coated specimens.
- FIG. 6 is an SEM showing the transverse section of a coated specimen.
- FIGS. 7 and 8 are SEMs showing transverse sections of a hydroxyapatite layer.
- FIG. 9 shows a typical building of layers in the preparation of transverse sections.
- FIG. 1 shows the typical surface after the laser treatment.
- the entire surface of the aluminum oxide ceramic was then subjected to plasma coating with hydroxyl apatite.
- FIGS. 2 and 3 show the surfaces of the lasered and hydroxyl apatite (HA) coated specimens.
- a ceramic component preferably a component made of aluminum oxide ceramic
- hydroxyapatite if the surface of the ceramic component is coated with a titanium layer.
- first ceramic components are provided with a thin titanium coating, for example by PVD (physical vapor deposition).
- the surface of the ceramic component can be previously roughened,—ground or lasered, for example.
- the thickness of the titanium layer was about 1 ⁇ m; a coating 5 ⁇ m thick also led to success.
- FIG. 6 shows the transverse section of a specimen coated in this manner.
- the hydroxyapatite layer was sprayed onto this intermediate layer.
- the transverse section of this built-up coating is represented in FIGS. 7 and 8 at different enlargements.
- the titanium intermediate layer is subjected also to a sand blasting process to improve adhesion.
- a sand blasting process to improve adhesion.
- an intermediate coating of the TiAl6V4 alloy can be deposited, for example by the PVD method.
- FIG. 9 shows the typical building of layers in the preparation of transverse sections.
- the corresponding strengths of adhesion are listed in Table 2.
- a ceramic component in the form of a cylindrical test specimen was used in the tests.
- the cylinders, with a diameter of 20 mm and a thickness of 2 mm, were made by the conventional press-turn manufacture as greenbodies, subjected to hot isostatic pressure and annealed.
- the sintered bodies were then machined with diamond tools to achieve final shape.
- Other methods for the manufacture of ceramic components can, of course, also be used.
- Used as the material was a known aluminum oxide material, such as the one known as Biolox® material, for example.
- ceramic components can for the first time be made, which can be used for medical purposes, for example as prostheses.
- Such prostheses display an improved ingrowth characteristic.
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Structural Engineering (AREA)
- Inorganic Chemistry (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Composite Materials (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Dental Preparations (AREA)
- Manufacturing & Machinery (AREA)
Abstract
The invention relates to a method for producing hydroxyapatite coated ceramics components. In a first step of the inventive method the ceramic component is provided with a Ti coating and in a second step a hydroxyapatite is applied to the Ti coating. The invention further relates to hydroxyapatite coated ceramic components produced according to the inventive method.
Description
- The subject of the present invention is a method for the manufacture of ceramic components coated with hydroxyapatite, as well as the ceramic components which can be manufactured by this method.
- It is known that prostheses which have a hydroxyapatite coating display an especially good ingrowth activity. Care must be taken, however, to see that the hydroxyapatite coating firmly adheres to the prosthesis. In the coating of titanium shafts with hydroxyapatite an especially great strength of adherence can be achieved when the metal surface is given a roughness of Ra≈40-50 μm.
- The adhesive strength of hydroxyapatite apatite on ceramic surfaces, especially on Al2O3 ceramics, is not sufficient for the desired use. Thus any direct coating of an aluminum oxide ceramic with hydroxyapatite, such as would be very advantageous for the direct fixation of the femur part of a knee prosthesis, is impossible. Even if the surface roughness is made similar to the roughness of the titanium shafts, the strength of the adhesion of hydroxyapatite is not assured. This has been proven in experiments in which ground and sand-blasted samples were used. In comparison with titanium materials the surface roughness of ceramic base materials thus treated is substantially lower. Coating tests with the standard parameters for titanium shafts resulted in no strength of adhesion between hydroxyapatite and aluminum oxide ceramic. Inasmuch as no coating adhered to aluminum oxide bodies under standard conditions, the spray parameters was also modified in the plasma coating apparatus. But even the modified process parameters did not lead to success. The cause of the poor strength of adhesion was determined to be the differences in roughness between the metal and the ceramic. A surface roughness of Ra≈30 μm cannot be achieved by conventional abrasive methods.
- Even methods which lead to increased depth of roughness did not bring the desired success. To produce a greater defined surface roughness, similar specimens were prepared for laser machining under various settings. In this manner it was possible to produce a lasting effect on the surfaces of the Al2O3 ceramic. While in the case of normal grinding a raw depth of no more than 1 μm could be achieved, the laser treatment succeeded in producing a raw depth of Ra≈9 μm. FIG. 3 shows the typical surface after the laser treatment. The lasered surface of the aluminum oxide ceramic was then subjected to plasma coating with hydroxyapatite. For the first time a few placed on this surface were detected, on which the hydroxyapatite coating could be detected. Of course, it was not possible even by this preliminary treatment to apply a continuous coating.
FIGS. 4 and 5 show the surfaces of the lasered and hydroxyapatite (HA) coated specimens. - Even though it was possible for the first time to prove the deposition of hydroxyapatite on the roughened surfaces of the aluminum oxide ceramic, the strength of adhesion of the coating was very poor. Quantification of the strength of adhesion was impossible, as was the preparation of a transverse section; the coating fell off immediately. Again, when the raw depth was analyzed it was compared with that of metal materials. With an Ra of 9 μm the raw depth of the TiAl6V4-1 alloy (Ra≈40 μm) could not be achieved. It was necessary to refrain from any further roughening of the surface in the ceramic substrate, since the aluminum oxide ceramic, unless metallic materials, has an absolute cleavage fracture tendency. If a “predamage” of 40 μm is induced, this “flaw” can trigger breakage. Thus, any further increase of the roughness is impossible from the viewpoint of fracture mechanics.
- The present invention is addressed to the problem of making available a method by which ceramic components can reliably be provided with a hydroxyapatite coating.
- The problem to which the invention is addressed has been solved by a method with the features of the principal claim. Preferred embodiments are described in the subclaims.
-
FIG. 1 is an SEM showing a typical surface after laser treatment. -
FIG. 2 and 3 are SEMs showing the surfaces of the lasered and hydroxyapatite coated specimens. -
FIGS. 4 and 5 are SEMs showing the transverse section of a lasered end and hydroxyapatite coated specimens. -
FIG. 6 is an SEM showing the transverse section of a coated specimen. -
FIGS. 7 and 8 are SEMs showing transverse sections of a hydroxyapatite layer. -
FIG. 9 shows a typical building of layers in the preparation of transverse sections. -
FIG. 1 shows the typical surface after the laser treatment. The entire surface of the aluminum oxide ceramic was then subjected to plasma coating with hydroxyl apatite. For the first time it was possible to detect on this surface a few spots on which the hydroxyl apatite coating could be detected. Nevertheless it was not possible even after this preliminary treatment to apply a continuous coating.FIGS. 2 and 3 show the surfaces of the lasered and hydroxyl apatite (HA) coated specimens. - Surprisingly it was possible according to the invention to coat a ceramic component, preferably a component made of aluminum oxide ceramic, with hydroxyapatite if the surface of the ceramic component is coated with a titanium layer. By the method of the invention it is surprisingly possible for the first time to deposit hydroapatic on the surface of a ceramic component, with sufficient strength of adhesion.
- According to the invention, first ceramic components are provided with a thin titanium coating, for example by PVD (physical vapor deposition). According to the invention, the surface of the ceramic component can be previously roughened,—ground or lasered, for example. The thickness of the titanium layer was about 1 μm; a coating 5 μm thick also led to success.
FIG. 6 shows the transverse section of a specimen coated in this manner. - The hydroxyapatite layer was sprayed onto this intermediate layer. The transverse section of this built-up coating is represented in
FIGS. 7 and 8 at different enlargements. - Preferably, before the hydroxyapatite is applied by plasma coating, for example, the titanium intermediate layer is subjected also to a sand blasting process to improve adhesion. An especially high strength of adhesion is achieved if the titanium coating is given a roughness of Ra≈40-50 μm.
- A scratch test on the hydroxyapatite coating confirmed the outstanding strength of adhesion of the coating. Preparation of a transverse section was possible without problems. The measurement of the strength of adhesion was made on five different specimens. The individual values are summarized in Table 1.
TABLE 1 Strength of adhesion of hydroxyapatite on Al2O3 with titanium primer Specimen Force [N] Tension [MPa] 1 718 2.3 2 1203 3.8 3 932 3 4 1490 4.7 5 390 1.2 - From the values obtained by the strength-of-adhesion measurements it can be seen that tensions are surprisingly achieved which are in the range of that of hydroxyapatite coatings on TiAl6V4 alloys.
- According to the invention, it is also possible, instead of the conventional titanium intermediate coating, an intermediate coating of the TiAl6V4 alloy can be deposited, for example by the PVD method.
-
FIG. 9 shows the typical building of layers in the preparation of transverse sections. The corresponding strengths of adhesion are listed in Table 2.Specimen Force [N] Tension [MPa] 1 582 1.9 2 700 2.2 3 400 1.3 4 498 1.6 - A ceramic component in the form of a cylindrical test specimen was used in the tests. The cylinders, with a diameter of 20 mm and a thickness of 2 mm, were made by the conventional press-turn manufacture as greenbodies, subjected to hot isostatic pressure and annealed. The sintered bodies were then machined with diamond tools to achieve final shape. Other methods for the manufacture of ceramic components can, of course, also be used. Used as the material was a known aluminum oxide material, such as the one known as Biolox® material, for example.
- With the present invention it is thus for the first time possible by providing a titanium intermediate coating to deposit hydroxyapatite directly onto ceramic components. The ceramic components that can be made by the method of the invention are also subject matter of the present invention.
- Thus, according to the invention, ceramic components can for the first time be made, which can be used for medical purposes, for example as prostheses. Such prostheses display an improved ingrowth characteristic.
Claims (15)
1-14. (canceled)
15. A method for the manufacture of an hydroxyapatite coated ceramic component, comprising coating a ceramic component with a titanium coating comprising at least one of titanium or TiAl6V4 alloy and applying hydroxyapatite to the titanium coating to produce the hydroxyapatite coated ceramic component, wherein the titanium coating is from 1 to 5 microns thick.
16. A method according to claim 15 , further comprising roughening a surface of the ceramic component before coating with titanium.
17. A method according to claim 15 , wherein said titanium coating is rough.
18. A method according to claim 15 , wherein said titanium coating is adjusted to a roughness of Ra≈40 to 50 μm.
19. A method according to claim 15 , wherein said titanium coating is deposited onto a surface of the ceramic component by a PVD process.
20. A method according to claim 15 , wherein said titanium coating comprises TiAl6V4 alloy and is applied to said ceramic component by a PVD process.
21. A method according to claim 15 , wherein said titanium coating is 5 micron thick.
22. A method according to claim 15 , wherein said hydroxyapatite is applied onto the Ti or TiAl6V4 coating by spraying
23. A method according to claim 15 , wherein said hydroxyapatite is applied to the Ti or TiAl6V4 coating by plasma coating.
24. A method according to claim 15 , wherein said ceramic component is an aluminum oxide ceramic.
25. A method according to claim 15 , wherein said ceramic component is for medical use.
26. A method according to claim 15 , wherein said ceramic component is a prosthesis.
27. A method according to claim 15 , wherein said titanium coating is 1 micron thick.
28. A hydroxyapatite coated ceramic component prepared according to the method of claim 15.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/252,377 US20060110607A1 (en) | 1999-12-21 | 2005-10-18 | Aluminum oxide ceramics with hydroxyapatite |
US12/072,326 US9216929B2 (en) | 1999-12-21 | 2008-02-26 | Aluminum oxide ceramics with hydroxyapatite |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19961917.4 | 1999-12-21 | ||
DE19961917 | 1999-12-21 | ||
PCT/EP2000/013109 WO2001046086A1 (en) | 1999-12-21 | 2000-12-21 | Coating aluminium oxide ceramics with hydroxyl apatite |
US10/168,414 US20030108658A1 (en) | 1999-12-21 | 2000-12-21 | Coating aluminium oxide ceramics with hydroxyl apatite |
US11/252,377 US20060110607A1 (en) | 1999-12-21 | 2005-10-18 | Aluminum oxide ceramics with hydroxyapatite |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10168414 Continuation | 2000-12-21 | ||
US10/168,414 Continuation US20030108658A1 (en) | 1999-12-21 | 2000-12-21 | Coating aluminium oxide ceramics with hydroxyl apatite |
PCT/EP2000/013109 Continuation WO2001046086A1 (en) | 1999-12-21 | 2000-12-21 | Coating aluminium oxide ceramics with hydroxyl apatite |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/072,326 Continuation US9216929B2 (en) | 1999-12-21 | 2008-02-26 | Aluminum oxide ceramics with hydroxyapatite |
Publications (1)
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US20060110607A1 true US20060110607A1 (en) | 2006-05-25 |
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ID=7933740
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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US10/168,414 Abandoned US20030108658A1 (en) | 1999-12-21 | 2000-12-21 | Coating aluminium oxide ceramics with hydroxyl apatite |
US11/252,377 Abandoned US20060110607A1 (en) | 1999-12-21 | 2005-10-18 | Aluminum oxide ceramics with hydroxyapatite |
US12/072,326 Expired - Fee Related US9216929B2 (en) | 1999-12-21 | 2008-02-26 | Aluminum oxide ceramics with hydroxyapatite |
Family Applications Before (1)
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US10/168,414 Abandoned US20030108658A1 (en) | 1999-12-21 | 2000-12-21 | Coating aluminium oxide ceramics with hydroxyl apatite |
Family Applications After (1)
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US12/072,326 Expired - Fee Related US9216929B2 (en) | 1999-12-21 | 2008-02-26 | Aluminum oxide ceramics with hydroxyapatite |
Country Status (7)
Country | Link |
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US (3) | US20030108658A1 (en) |
EP (1) | EP1244606B1 (en) |
AT (1) | ATE294151T1 (en) |
AU (1) | AU3015501A (en) |
DE (2) | DE10064355A1 (en) |
ES (1) | ES2241689T3 (en) |
WO (1) | WO2001046086A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0226997D0 (en) * | 2002-11-19 | 2002-12-24 | Welding Inst | Heat resistant product |
EP2011779A1 (en) * | 2007-07-06 | 2009-01-07 | Vita Zahnfabrik H. Rauter GmbH & Co. KG | Ceramic body and method for its production |
GB0821927D0 (en) * | 2008-12-01 | 2009-01-07 | Ucl Business Plc | Article and method of surface treatment of an article |
US10537658B2 (en) | 2017-03-28 | 2020-01-21 | DePuy Synthes Products, Inc. | Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same |
US10537661B2 (en) | 2017-03-28 | 2020-01-21 | DePuy Synthes Products, Inc. | Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same |
CN112919888B (en) * | 2021-03-26 | 2022-06-14 | 华南理工大学 | Alumina ceramic with HA-coated surface and preparation method thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4818559A (en) * | 1985-08-08 | 1989-04-04 | Sumitomo Chemical Company, Limited | Method for producing endosseous implants |
DE3844157A1 (en) * | 1988-12-23 | 1990-06-28 | Mecron Med Prod Gmbh | ENDOPROTHESIS |
JP2883214B2 (en) * | 1990-12-28 | 1999-04-19 | 京セラ株式会社 | Biological implant material and its manufacturing method |
JPH06189977A (en) * | 1992-12-24 | 1994-07-12 | Nikon Corp | Interaosseous implant |
IT1288038B1 (en) * | 1996-04-30 | 1998-09-10 | Flametal S P A | PROCEDURE FOR THE PREPARATION OF HYDROXYAPATITE COATINGS |
US6261322B1 (en) * | 1998-05-14 | 2001-07-17 | Hayes Medical, Inc. | Implant with composite coating |
JP4091728B2 (en) * | 2000-03-27 | 2008-05-28 | 京セラ株式会社 | Bioimplant material and its manufacturing method |
-
2000
- 2000-12-21 EP EP00990810A patent/EP1244606B1/en not_active Expired - Lifetime
- 2000-12-21 US US10/168,414 patent/US20030108658A1/en not_active Abandoned
- 2000-12-21 AU AU30155/01A patent/AU3015501A/en not_active Abandoned
- 2000-12-21 WO PCT/EP2000/013109 patent/WO2001046086A1/en active IP Right Grant
- 2000-12-21 ES ES00990810T patent/ES2241689T3/en not_active Expired - Lifetime
- 2000-12-21 DE DE10064355A patent/DE10064355A1/en not_active Ceased
- 2000-12-21 DE DE50010191T patent/DE50010191D1/en not_active Expired - Lifetime
- 2000-12-21 AT AT00990810T patent/ATE294151T1/en not_active IP Right Cessation
-
2005
- 2005-10-18 US US11/252,377 patent/US20060110607A1/en not_active Abandoned
-
2008
- 2008-02-26 US US12/072,326 patent/US9216929B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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ES2241689T3 (en) | 2005-11-01 |
ATE294151T1 (en) | 2005-05-15 |
AU3015501A (en) | 2001-07-03 |
DE50010191D1 (en) | 2005-06-02 |
WO2001046086A1 (en) | 2001-06-28 |
DE10064355A1 (en) | 2001-06-28 |
EP1244606B1 (en) | 2005-04-27 |
US20030108658A1 (en) | 2003-06-12 |
EP1244606A1 (en) | 2002-10-02 |
WO2001046086A9 (en) | 2002-09-06 |
US9216929B2 (en) | 2015-12-22 |
US20080152783A1 (en) | 2008-06-26 |
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